Break-Induced Replication Repair of Damaged Forks Induced Genomic Duplications in Human Cells.

Science 2014, 343, 88-91

Effects of chromatin decondensation on backup NHEJ

DNA Repair 2013, 12, 972-981

Dueva R, Iliakis G

Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer.

Transl Cancer Res 2013, 2, 163-177

DNA Ligases I and III Cooporate in Alternative Non-Homologous End-Joining in Vertebrates.

PLoS One 2013, 8: e59505

Lipofection and nucleofection of substrate plasmid can generate widely different readings of DNA end-joining efficiency in different cell lines.

DNA Repair 2013, 12: 148-160

Analysis of Inhibition of DNA Replication in Irradiated Cells Using the SV40 Based In Vitro Assay of DNA Replication.

Methods Mol Biol 2012, 920: 591-602

Processing of DNA double strands breaks by alternative non-homologous end-joining in hyperacetylated chromatin.

Genome Integrity 2012, 3:4 doi:10.1186/2041-9414-3-4

Inhibition of B-NHEJ in Plateau-Phase Cells Is Not a Direct Consequence of Suppressed Growth Factor Signaling.

Int J Radiat Oncol Biol Phys 2012, 84: e237-e243

Targeting DNA damage and repair: Embracing the pharmacological era for successful cancer therapy.

Pharmacology & Therapeutics 2012, 133: 334-350

Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells.
Nucleic Acids Res. 2011 Nov 29.

Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways.
Mutat Res. 2011 Feb 15.

Widespread Dependence of Backup NHEJ on Growth State: Ramifications for the Use of DNA-PK Inhibitors.
Int J Radiat Oncol Biol Phys. 2011 Feb 1;79(2):540-8.

Evidence of an adaptive response targeting DNA nonhomologous end joining and its transmission to bystander cells.
Cancer Res. 2010 Nov 1;70(21):8498-506. Epub 2010 Sep 22.

Initial characterization of a low-molecular-weight factor enhancing the checkpoint response.
Radiat Res. 2010 Oct;174(4):424-35.

New partners for Chk1.
Cell Cycle. 2010 Jun 1;9(11).

Investigation of bystander effects in hybrid cells by means of cell fusion and premature chromosome condensation induction.
Radiat Res. 2010 Jun;173(6):789-801.

The anatomy and cell cycle evolution of DNA damage signaling and repair foci.
Cell Cycle. 2010 Feb;9(3):444-5. Epub 2010 Feb 1.

Extensive repair of DNA double-strand breaks in cells deficient in the DNA-PK-dependent pathway of NHEJ after exclusion of heat-labile sites.
Radiat Res. 2009 Aug;172(2):152-64.

Backup pathways of NHEJ in cells of higher eukaryotes: cell cycle dependence.
Radiother Oncol. 2009 Sep;92(3):310-5. Epub 2009 Jul 13.

Application of alkaline sucrose gradient centrifugation in the analysis of DNA replication after DNA damage.
Methods Mol Biol. 2009;521:329-42.

Premature chromosome condensation reveals DNA-PK independent pathways of chromosome break repair.
Int J Oncol. 2008 Oct;33(4):871-9.

Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin.
Nucleic Acids Res. 2008 Oct;36(17):5678-94. Epub 2008 Sep 4.

Enhanced use of backup pathways of NHEJ in G2 in Chinese hamster mutant cells with defects in the classical pathway of NHEJ.
Radiat Res. 2008 Oct;170(4):512-20.

Histone H1 functions as a stimulatory factor in backup pathways of NHEJ.
Nucleic Acids Res. 2008 Mar;36(5):1610-23. Epub 2008 Feb 3.

DNA double strand break repair inhibition as a cause of heat radiosensitization: re-evaluation considering backup pathways of NHEJ.
Int J Hyperthermia. 2008 Feb;24(1):17-29.

Repair of radiation induced DNA double strand breaks by backup NHEJ is enhanced in G2.
DNA Repair (Amst). 2008 Feb 1;7(2):329-38. Epub 2007 Dec 26.

Marked dependence on growth state of backup pathways of NHEJ.
Int J Radiat Oncol Biol Phys. 2007 Aug 1;68(5):1462-70.

Low levels of DNA ligases III and IV sufficient for effective NHEJ.
J Cell Physiol. 2007 Nov;213(2):475-83.

Analysis of inhibition of DNA replication in irradiated cells using the SV40-based in vitro assay of DNA replication.
Methods Mol Biol. 2006;314:61-71.

In vitro rejoining of double-strand breaks in genomic DNA.
Methods Mol Biol. 2006;314:95-108.

Plasmid-based assays for DNA end-joining in vitro.
Methods Mol Biol. 2006;314:123-31.

Homology-directed repair is required for the development of radioresistance during S phase: interplay between double-strand break repair and checkpoint response. (PubMed)
Radiat Res. 2007 Jan;167(1):1-11

Computational Methods for Analysis of Foci: Validation for Radiation-Induced g-H2AX Foci in Human Cells
RADIATION RESEARCH 165, 113–124 (2006)

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
6170–6182 Nucleic Acids Research, 2006, Vol. 34, No. 21

Cell Line Specific Modulation of Connexin43 Expression after Exposure to Ionizing Radiation
Cell Communication and Adhesion, 12: 249–259, 2005

Checkpoint abrogation in G2 compromises repair of chromosomal breaks in ataxia telangiectasia cells.
Cancer Res. 2005 Dec 15;65(24):11292-6

Postreplicative Joining of DNA Double-Strand Breaks Causes Genomic Instability in DNA-PKcs–Deficient Mouse Embryonic Fibroblasts
Cancer Res 2005; 65: (22). November 15, 2005

Complex H2AX Phosphorylation Patterns by Multiple Kinases Including ATM and DNA-PK in Human Cells Exposed to Ionizing Radiation and Treated With Kinase Inhibitors
JOURNAL OF CELLULAR PHYSIOLOGY 202:492–502 (2005)

DNA Ligase III as a Candidate Component of Backup Pathways of Nonhomologous End Joining
Cancer Res 2005; 65: (10). May 15, 2005

Interferon alpha 2a downregulates VEGF expression through PI3 kinase and MAP kinase signaling pathways
J Cancer Res Clin Oncol (2005) 131: 169–178

ATR Affecting Cell Radiosensitivity Is Dependent on Homologous Recombination Repair but Independent of Nonhomologous End Joining
CANCER RESEARCH 64, 7139–7143, October 1, 2004

Evidence for an S-Phase checkpoint regulating DNA replication after heat shock: a review
INT. J. HYPERTHERMIA VOL. 20, NO. 2 (MARCH 2004), pp. 240–249

Mechanisms of DNA double strand break repair and chromosome aberration formation
Cytogenet Genome Res 104:14–20 (2004)

Backup Pathways of NHEJ Are Suppressed by DNA-PK
Journal of Cellular Biochemistry 92:781–794 (2004)

Caffeine inhibits homology-directed repair of I-SceI-induced DNA double-strand breaks
Oncogene (2004) 23, 824–834

Involvement of Hus1 in the chain elongation step of DNA replication after exposure to camptothecin or ionizing radiation
Nucleic Acids Research, 2004, Vol. 32, No. 2 767 - 775

Targeting Angiogenic Processes by Combination Low-Dose Paclitaxel and Radiation Therapy
Am J Clin Oncol (CCT) 26(3): e45–e53, 2003

DNA damage checkpoint control in cells exposed to ionizing radiation
Oncogene (2003) 22, 5834–5847

hTERT associates with human telomeres and enhances genomic stability and DNA repair
Oncogene (2003) 22, 131–146

Caffeine-Induced Radiosensitization is Independent of Nonhomologous End Joining of DNA Double-Strand Breaks
RADIATION RESEARCH 159, 426–432 (2003)

Caffeine Could Not Efficiently Sensitize Homologous Recombination Repair-Deficient Cells to Ionizing Radiation-Induced Killing
RADIATION RESEARCH 159, 420–425 (2003)

An Overactivated ATR/CHK1 Pathway Is Responsible for the Prolonged G2 Accumulation in Irradiated AT Cells
THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 278, No. 33, Issue of August 15, pp. 30869–30874, 2003

Biochemical evidence for Ku-independent backup pathways of NHEJ
Nucleic Acids Research, 2003, Vol. 31, No. 18 5377±5388

Effects of Hyperthermia on p53 Protein Expression and Activity
Journal of Cellular Physiology 190:365-374 (2002)

Ku Affects the Ataxia and Rad 3-related/CHK1-dependent S Phase Checkpoint Response after Camptothecin Treatment
CANCER RESEARCH 62, 2483–2487, May 1, 2002

Ku Affects the CHK1-dependent G2 Checkpoint after Ionizing Radiation
CANCER RESEARCH 62, 6031–6034, November 1, 2002

CHK1-Tegulated S-phase Checkpoint Response Reduces Camptothecin Cytotoxity
Cell Cycle 1:4, 267-272, July/August 2002

DNA-PKcs subunits in radiosensitization by hyperthermia on hepatocellular carcinoma hepG2 cell line
World J Gastroenterol 2002;8(5):797-803

An ATM-independent S-Phase Checkpoint Response Involves CHK1 Pathway
CANCER RESEARCH 62, 1598–1603, March 15, 2002

Ku affects the ATM-dependent S phase checkpoint following ionizing radiation
Oncogene (2002) 21, 6377 – 6381

Results of a Pilot Study Involving the Use of an Antisense Oligodeoxynucleotide Directed Against the Insulin-Like Growth Factor Type I Receptor in Malignant Astrocytomas
Journal of Clinical Oncology, Vol 19, No 8 (April 15), 2001: pp 2189-2200

Evidence for factors modulating radiation-induced G2-delay: potential application as radioprotectors
Physica Medica - Vol. XVII, Supplement 1, 2001

The Radioresistance to Killing of A1–5 Cells Derives from Activation of the Chk1 Pathway
THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 276, No. 21, Issue of May 25, pp. 17693–17698, 2001

RPA facilitates rejoining of DNA double-strand breaks in an in vitro assay utilizing genomic DNA as substrate
int. j. radiat. biol 2001, vol. 77, no. 5, 593± 607

Inhibition of DNA Replication by Tirapazamine
CANCER RESEARCH 61, 5425–5431, July 15, 2001

Nonhomologous End-Joining of Ionizing Radiation-induced DNA Double-Stranded Breaks in Human Tumor Cells Deficient in BRCA1 or BRCA2
CANCER RESEARCH 61, 270–277, January 1, 2001

Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells
Nucleic Acids Research, 2001, Vol. 29, No. 8 1653-1660

Regulation of DNA Replication after Heat Shock by Replication Protein A-Nucleolin Interactions
THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 276, No. 23, Issue of June 8, pp. 20579–20588, 2001

Effcient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group
Oncogene (2001) 20, 2212 - 2224

Replication Protein A2 Phosphorylation after DNA Damage by the Coordinated Action of Ataxia Telangiectasia-Mutated and DNA-dependent Protein Kinase
CANCER RESEARCH 61, 8554–8563, December 1, 2001

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining
8644–8649 | PNAS | July 17, 2001 | vol. 98 | no. 15

Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants
Oncogene (2000) 19, 5788 - 5800

DNA-dependent Protein Kinase Stimulates an Independently Active, Nonhomologous, End-Joining Apparatus
CANCER RESEARCH 60, 1245–1253, March 1, 2000

The catalytic subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery from radiation-induced inhibition of DNA replication
Nucleic Acids Research, 2000, Vol. 28, No. 5 1183-1192

Hyperthermia does not affect rejoining of DNA double-strand breaks in a cell-free assay
int. j. radiat. biol 2000, vol. 76, no. 3, 313 - 326