CRC 1430
Welcome to the Collaborative Research Centre "Molecular Mechanisms of Cell State Transitions" (CRC 1430)
The DFG-funded CRC 1430 "Molecular Mechanisms of Cell State Transitions" explores fundamental molecular mechanisms that underlie the regulation of cell proliferation. Cell proliferation needs to be tightly controlled to ensure organismal development and tissue regeneration, while preventing neoplastic disorders. A key hallmark of this control is the establishment of distinct, biochemically or epigenetically defined cell states and the regulated transitions between these states.
These transitions govern cell cycle progression and underlie cancer cell plasticity and cancer therapy resistance. The research focus is on understanding the switch-like molecular trigger mechanisms of state transitions and develop means to modulate them, ultimately to identify novel therapeutic strategies. Specifically, to overcome current limitations, the CRC 1430 will develop and apply direct methodologies such as advanced biochemical reconstitution and novel approaches of acute chemical or optical perturbation to decipher how the key triggers sense, integrate and transmit signals to regulatory circuits that define cell states.
Upcoming CRC 1430 Guest Lectures
30.04.2024 | Monilola Olayioye Institute of Cell Biology and Immunology, University of Stuttgart |
04.06.2024 | Silvia Vega Rubin de Celis Institut für Zellbiologie (Tumorforschung), UKE |
25.06.2024 | Yogesh Kulathu MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee |
23.07.2024 | Jacques Neefjes Cell and Chemical Biology, Leiden University Medical Center |
26.11.2024 | Georg Winter Center for Molecular Medicine, Austrian Academy of Sciences |
A list of previous speakers can be found here:
Upcoming CRC1430 Workshops
16.11.2023 | Story Telling Techniques for Scientific Presentations Guido Molina |
29.11.2023 | Introduction to R INF & RDS |
A list of previous workshops can be found here:
NEWS
14 March 2024 PhD thesis defense
Congratulations to Kristina Mrug, who successfully defended her PhD thesis "Regulation of the pulsatory contraction signal network dynamics during cell division" on March 14, 2024.
February 01, 2024 How Cells migrate
Two new papers on cell migration were published by Prof. Dr. Perihan Nalbant (MB) in cooperation with Dr. Leif Dehmelt (Chemistry and Chemical Biology, TU Dortmund).
For efficient cell migration dynamic cell shape changes need to be coordinated. Most cell types form protrusions in the front and a retracting tail. In these two papers the groups used TIRF microscopy and translocation sensors to measure Rho GTPase activity which play a key role in the spatio-temporal coordination of the relevant cytoskeletal dynamics.
October 10-12, 2023 1st International Symposium: "Triggers of Cell State Transitions"
We thank all speakers and participants for contributing to the success of our 1st International Symposium Triggers of Cell State Transitions!
Location: Glaspavillon, University Duisburg-Essen, Campus Essen