Faculty of Biology

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Prof. Dr. Robert Huber

Room
S03 S02 A48
Phone
+49 201 183 4141
Fax
0201 183-3135
E-Mail
huber@biochem.mpg.de
Website
https://www.uni-due.de/zmb/members/robert-huber.php

Functions

  • Gastprofessor/in, Biologie - Mikrobiologie II

  • Gastwissenschaftler/in, Biologie - Mikrobiologie II

  • Professor/in, Mikrobiologie II

Current lectures

No current lectures.

Past lectures (max. 10)

The following publications are listed in the online university bibliography of the University of Duisburg-Essen. Further information may also be found on the person's personal web pages.

    Journal articles

  • Fehr, Lorenz; Sewald, Leonard; Huber, Robert; Kaiser, Markus
    Facile Multicomponent Synthesis of Oxazolidinones from Primary Amines and Cesium (Hydrogen)Carbonate
    In: European Journal of Organic Chemistry Vol. 26 (2023) Nr. 27, e202300135
    Online Full Text: dx.doi.org/ (Open Access)
  • Wolf, Christine; Fischer, Hannah; Kühl, Jörn-Sven; Koss, Sarah; Jamra, Rami Abou; Starke, Sven; Schultz, Jurek; Ehl, Stephan; Neumann, Katrin; Schuetz, Catharina; Huber, Robert; Hornung, Veit; Lee-Kirsch, Min Ae
    Hemophagocytic lymphohistiocytosis : Like hyperinflammation due to a de novo mutation in DPP9
    In: The Journal of Allergy and Clinical Immunology Vol. 152 (2023) Nr. 5, pp. 1336 - 1344.e5
    Online Full Text: dx.doi.org/
  • Carvalho, Luís A. R.; Ross, Breyan; Fehr, Lorenz; Bolgi, Oguz; Wöhrle, Svenja; Lum, Kenneth M.; Podlesainski, David; Vieira, Andreia C.; Kiefersauer, Reiner; Félix, Rita; Rodrigues, Tiago; Lucas, Susana D.; Groß, Olaf; Geiss‐Friedlander, Ruth; Cravatt, Benjamin F.; Huber, Robert; Kaiser, Markus; Moreira, Rui
    Chemoproteomics‐Enabled Identification of 4‐Oxo‐β‐Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9
    In: Angewandte Chemie International Edition Vol. 61 (2022) Nr. 47, e202210498
    Online Full Text: dx.doi.org/ (Open Access)
  • Bolgi, Oguz; Silva-Garcia, Maria; Ross, Breyan; Pilla, Esther; Kari, Vijayalakshmi; Killisch, Markus; Spitzner, Melanie; Stark, Nadine; Lenz, Christof; Weiss, Konstantin; Donzelli, Laura; Gorrell, Mark D.; Grade, Marian; Riemer, Jan; Urlaub, Henning; Dobbelstein, Matthias; Huber, Robert; Geiss-Friedlander, Ruth
    Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair
    In: EMBO Reports Vol. 23 (2022) Nr. 10, e54136
    Online Full Text: dx.doi.org/ (Open Access)
  • Ross, Breyan; Krapp, Stephan; Geiss-Friedlander, Ruth; Littmann, Walter; Huber, Robert; Kiefersauer, Reiner
    Aerosol-based ligand soaking of reservoir-free protein crystals
    In: Journal of Applied Crystallography Vol. 54 (2021) Nr. 3, pp. 895 - 902
    Online Full Text: dx.doi.org/ (Open Access)
  • Lee, Jung-Hoon; Bollschweiler, Daniel; Schäfer, Tillman; Huber, Robert
    Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies
    In: Science Advances Vol. 7 (2021) Nr. 2, pp. eabd4413
    Online Full Text: dx.doi.org/ (Open Access)
  • Klatt, Felix; Leitner, Alexander; Kim, Iana V.; Ho-Xuan, Hung; Schneider, Elisabeth V.; Langhammer, Franziska; Weinmann, Robin; Müller, Melanie R.; Huber, Robert; Meister, Gunter; Kuhn, Claus-D.
    A precisely positioned MED12 activation helix stimulates CDK8 kinase activity
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 117 (2020) Nr. 6, pp. 2894 - 2905
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Merdanovic, Melisa; Burston, Steven G.; Schmitz, Anna Laura; Köcher, Steffen; Knapp, Stefan; Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Activation by substoichiometric inhibition
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 117 (2020) Nr. 3, pp. 1414 - 1418
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Garcia-Guerrero, Maria C.; Garcia-Pardo, Javier; Berenguer, Esther; Fernandez-Alvarez, Roberto; Barfi, Gifty B.; Lyons, Peter J.; Aviles, Francesc X.; Huber, Robert; Lorenzo, Julia; Reverter, David
    Crystal structure and mechanism of human carboxypeptidase O : Insights into its specific activity for acidic residues
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 115 (2018) Nr. 17, pp. E3932 - E3939
    Online Full Text: dx.doi.org/ (Open Access)
  • Ross, Breyan; Krapp, Stephan; Augustin, Martin; Kierfersauer, Reiner; Arciniega, Marcelino; Geiss-Friedlander, Ruth; Huber, Robert
    Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 115 (2018) Nr. 7, pp. E1437 - E1445
    Online Full Text: dx.doi.org/ (Open Access)
  • Dahms, Sven O.; Arciniega, Marcelino; Steinmetzer, Torsten; Huber, Robert; Than, Manuel E.
    Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 113 (2016) Nr. 40, pp. 11196 - 11201
    Online Full Text: dx.doi.org/ (Open Access)
  • Hierold, Judith; Baek, Sohee; Rieger, Rene; Lim, Tae-Guy; Zakpur, Saman; Arciniega, Marcelino; Lee, Kiwon; Huber, Robert; Tietze, Lutz Friedjan
    Design, Synthesis, and Biological Evaluation of Quercetagetin Analogues as JNK1 Inhibitors
    In: Chemistry - A European Journal Vol. 21 (2015) Nr. 47, pp. 16887 - 16894
    Online Full Text: dx.doi.org/
  • Park, Gaeun; Baek, Sohee; Kim, Jong-Eun; Lim, Tae-gyu; Lee, Charles C.; Yang, Hee; Kang, Young-Gyu; Park, Jun Seong; Augustin, Martin; Mrosek, Michael; Lee, Chang Yong; Dong, Zigang; Huber, Robert; Lee, Ki Won
    Flt3 is a target of coumestrol in protecting against UVB-induced skin photoaging
    In: Biochemical Pharmacology Vol. 98 (2015) Nr. 3, pp. 473 - 483
    Online Full Text: dx.doi.org/
  • Beaufort, Nathalie; Scharrer, Eva; Kremmer, Elisabeth; Lux, Vanda; Ehrmann, Michael; Huber, Robert; Houlden, Henry H.; Werring, David John; Haffner, Christof; Dichgans, Martin
    Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 111 (2014) Nr. 46, pp. 16496 - 16501
    Online Full Text: dx.doi.org/
  • Arciniega, M.; Beck, P.; Lange, O. F.; Groll, M.; Huber, Robert
    Differential global structural changes in the core particle of yeast and mouse proteasome induced by ligand binding
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 111 (2014) Nr. 26, pp. 9479 - 9484
    Online Full Text: dx.doi.org/
  • Kiefersauer, Reiner; Grandl, Brigitte; Krapp, S.; Huber, Robert
    IR laser-induced protein crystal transformation
    In: Acta Crystallographica Section D: Biological Crystallography Vol. D70 (2014) Nr. 5, pp. 1224 - 1232
    Online Full Text: dx.doi.org/ (Open Access)
  • Lesca, E.; Lammens, A.; Huber, Robert; Augustin, M.
    Structural analysis of the human fibroblast growth factor receptor 4 kinase
    In: Journal of Molecular Biology (JMB) Vol. 426 (2014) Nr. 22, pp. 3744 - 3756
    Online Full Text: dx.doi.org/
  • Baek, Sohee; Kang, Nam Joo; Popowicz, Grzegorz M.; Arciniega, Marcelino; Jung, Sung Keun; Byun, Sanguine; Song, Nu Ry; Heo, Yong-Seok; Kim, Bo Yeon; Lee, Hyong Joo; Holak, Tad A.; Augustin, Martin; Bode, Ann M.; Huber, Robert; Dong, Zigang; Lee, Ki Won
    Structural and Functional Analysis of the Natural JNK1 Inhibitor Quercetagetin
    In: Journal of Molecular Biology (JMB) Vol. 425 (2013) Nr. 2, pp. 411 - 423
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Schneider, Elisabeth V.; Böttcher, Jark; Huber, Robert; Maskos, Klaus; Neumann, Lars
    Structure-kinetic relationship study of CDK8/CycC specific compounds
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 110 (2013) Nr. 20, pp. 8081 - 8086
    Online Full Text: dx.doi.org/
  • Huber, Robert
    “How I Chose Research on Proteases or, More Correctly, How it Chose Me”
    In: Angewandte Chemie International Edition Vol. 52 (2013) Nr. 1, pp. 68 - 73
    Online Full Text: dx.doi.org/
  • Weski, Juliane; Meltzer, Michael; Spaan, Lina; Mönig, Timon; Oeljeklaus, Julian; Hauske, Patrick; Vouilleme, Lars; Volkmer, Rudolf; Boisguerin, Prisca; Boyd, Dana; Huber, Robert; Kaiser, Markus; Ehrmann, Michael
    Chemical Biology Approaches Reveal Conserved Features of a C-Terminal Processing PDZ Protease
    In: ChemBioChem Vol. 13 (2012) Nr. 3, pp. 402 - 408
    Online Full Text: dx.doi.org/
  • Tennstaedt, Annette; Pöpsel, Simon; Trübestein, Linda; Hauske, Patrick; Brockmann, Anke; Schmidt, Nina; Irle, Inga; Sacca, Barbara; Niemeyer, Christof M.; Brandt, Roland; Ksiezak-Reding, Hanna; Tirniceriu, Anca Laura; Egensperger, Rupert; Baldi, Alfonso; Dehmelt, Leif; Kaiser, Markus; Huber, Robert; Clausen, Tim; Ehrmann, Michael
    Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates
    In: The Journal of Biological Chemistry (JBC) Vol. 287 (2012) Nr. 25, pp. 20931 - 20941
    Online Full Text: dx.doi.org/
  • Gallastegui, Nerea; Beck, Philipp; Arciniega, Marcelino; Huber, Robert; Hillebrand, Stefan; Groll, Michael
    Hydroxyureas as noncovalent proteasome inhibitors
    In: Angewandte Chemie International Edition Vol. 51 (2012) Nr. 1, pp. 247 - 249
    Online Full Text: dx.doi.org/
  • Baek, Sohee; Kutchukian, Peter S.; Verdine, Gregory L.; Huber, Robert; Holak, Tad A.; Lee, Ki Won; Popowicz, Grzegorz M.
    Structure of the stapled p53 peptide bound to Mdm2
    In: Journal of the American Chemical Society: JACS Vol. 134 (2012) Nr. 1, pp. 103 - 106
    Online Full Text: dx.doi.org/
  • Gallastegui, Nerea; Stein, Martin; Schmidt, Boris; Kloetzel, Peter-Michael; Huber, Robert; Groll, Michael; Gräwert, Melissa Ann
    Elucidation of the α-keto-aldehyde binding mechanism : A lead structure motif for proteasome inhibition
    In: Angewandte Chemie International Edition Vol. 50 (2011) Nr. 2, pp. 542 - 544
    Online Full Text: dx.doi.org/
  • Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    HTRA proteases : regulated proteolysis in protein quality control
    In: Nature Reviews Molecular Cell Biology Vol. 12 (2011) Nr. 3, pp. 152 - 162
    Online Full Text: dx.doi.org/
  • Sitar, Tomasz; Gallinger, Julia; Ducka, Anna M.; Ikonen, Teemu P.; Wohlhoefler, Michael; Schmoller, Kurt M.; Bausch, Andreas R.; Joel, Peteranne; Trybus, Kathleen M.; Noegel, Angelika A.; Schleicher, Michael; Huber, Robert; Holak, Tad A.
    Molecular architecture of the Spire-actin nucleus and its implication for actin filament assembly
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 108 (2011) Nr. 49, pp. 19575 - 19580
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Merdanovic, Melisa; Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Protein quality control in the bacterial periplasm
    In: Annual Review of Microbiology Vol. 65 (2011) pp. 149 - 168
    Online Full Text: dx.doi.org/
  • Schneider, Elisabeth V.; Böttcher, Jark; Blaesse, Michael; Neumann, Lars; Huber, Robert; Maskos, Klaus
    The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder
    In: Journal of Molecular Biology (JMB) Vol. 412 (2011) Nr. 2, pp. 251 - 266
    Online Full Text: dx.doi.org/
  • Clerc, Jérôme; Schellenberg, Barbara; Groll, Michael; Bachmann, André S.; Huber, Robert; Dudler, Robert; Kaiser, Markus
    Convergent synthesis and biological evaluation of syringolin a and derivatives as eukaryotic 20S proteasome inhibitors
    In: European Journal of Organic Chemistry (2010) Nr. 21, pp. 3991 - 4003
    Online Full Text: dx.doi.org/
  • Hasenbein, Sonja; Meltzer, Michael; Hauske, Patrick; Kaiser, Markus; Huber, Robert; Clausen, Tim; Ehrmann, Michael
    Conversion of a regulatory into a degradative protease
    In: Journal of Molecular Biology (JMB) Vol. 397 (2010) Nr. 4, pp. 957 - 966
    Online Full Text: dx.doi.org/
  • Merdanovic, Melisa; Mamant, Nicolette; Meltzer, Michael; Poepsel, Simon; Auckenthaler, Alexandra; Melgaard, Rie; Hauske, Patrick; Nagel-Steger, Luitgard; Clarke, Anthony R.; Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Determinants of structural and functional plasticity of a widely conserved protease chaperone complex
    In: Nature Structural & Molecular Biology Vol. 17 (2010) Nr. 7, pp. 837 - 843
    Online Full Text: dx.doi.org/
  • Krojer, Tobias; Sawa, Justyna; Huber, Robert; Clausen, Tim
    HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues
    In: Nature Structural & Molecular Biology Vol. 17 (2010) Nr. 7, pp. 844 - 852
    Online Full Text: dx.doi.org/
  • Ducka, Anna M.; Joel, Peteranne; Popowicz, Grzegorz M.; Trybus, Kathleen M.; Schleicher, Michael; Noegel, Angelika A.; Huber, Robert; Holak, Tad A.; Sitar, Tomasz
    Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 107 (2010) Nr. 26, pp. 11757 - 11762
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Ottmann, Christian; Rose, Rolf; Huttenlocher, Franziska; Cedzich, Anna; Hauske, Patrick; Kaiser, Markus; Huber, Robert; Schaller, Andreas
    Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 106 (2009) Nr. 40, pp. 17223 - 17228
    Online Full Text: dx.doi.org/
  • Meltzer, Michael; Hasenbein, Sonja; Mamant, Nicolette; Merdanovic, Melisa; Poepsel, Simon; Hauske, Patrick; Kaiser, Markus; Huber, Robert; Krojer, Tobias; Clausen, Tim; Ehrmann, Michael
    Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli
    In: Research in Microbiology Vol. 160 (2009) Nr. 9, pp. 660 - 666
    Online Full Text: dx.doi.org/
  • Clerc, Jérôme; Groll, Michael; Illich, Damir J.; Bachmann, André S.; Huber, Robert; Schellenberg, Barbara; Dudler, Robert; Kaiser, Markus
    Synthetic and structural studies on Syringolin A and B reveal critical determinants for selectivity and potency of proteasome inhibition
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 106 (2009) Nr. 16, pp. 6507 - 6512
    Online Full Text
  • Clerc, Jérôme; Florea, Bogdan I.; Kraus, Marianne; Groll, Michael; Huber, Robert; Bachmann, André S.; Dudler, Robert; Driessen, Christoph; Overkleeft, Herman S.; Kaiser, Markus
    Syringolin A selectively labels the 20S proteasome in murine EL4 and wildtype and bortezomib adapted leukemic cell lines
    In: ChemBioChem Vol. 10 (2009) Nr. 16, pp. 2638 - 2643
    Online Full Text: dx.doi.org/ Online Full Text
  • Groll, Michael; Schellenberg, Barbara; Bachmann, André S.; Archer, Crystal R.; Huber, Robert; Powell, Tracy K.; Lindow, Steven; Kaiser, Markus; Dudler, Robert
    A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
    In: Nature Vol. 452 (2008) pp. 755 - 758
    Online Full Text
  • Krojer, Tobias; Pangerl, Karen; Kurt, Juliane; Sawa, Justyna; Stingl, Christoph; Mechtler, Karl; Huber, Robert; Ehrmann, Michael; Clausen, Tim
    Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 22 (2008) pp. 7702 - 7707
    Online Full Text
  • Kaiser, Markus; Groll, Michael; Siciliano, Carlo; Assfalg-Machleidt, Irmgard; Weyher, Elisabeth; Kohno, Jun; Milbradt, Alexander G.; Renner, Christian; Huber, Robert; Moroder, Luis
    Binding mode of TMC-95A analogues to eukaryotic 20S proteasome
    In: ChemBioChem Vol. 5 (2004) Nr. 9, pp. 1256 - 1266
    Online Full Text: dx.doi.org/
  • Kim, Jeong-Sun; Groll, Michael; Musiol, Hans-Jürgen; Behrendt, Raymond; Kaiser, Markus; Moroder, Luis; Huber, Robert; Brandstetter, Hans
    Navigation inside a protease: Substrate selection and product exit in the tricorn protease from Thermoplasma acidophilum
    In: Journal of Molecular Biology (JMB) Vol. 324 (2002) Nr. 5, pp. 1041 - 1050
    Online Full Text: dx.doi.org/
  • Kaiser, Markus; Groll, Michael; Renner, Christian; Huber, Robert; Moroder, Luis
    The Core Structure of TMC-95A Is a Promising Lead for Reversible Proteasome Inhibition
    In: Angewandte Chemie International Edition Vol. 41 (2002) Nr. 5, pp. 780 - 783
    Online Full Text: dx.doi.org/

    • Book articles / Proceedings papers

  • Huber, Robert; Kaiser, Markus; Ehrmann, Michael
    Proteases ☆
    In: Reference Module in Life Sciences 2017
    Online Full Text: dx.doi.org/
  • Kaiser, Markus; Huber, Robert; Ehrmann, Michael
    Proteolysis
    In: Brenner's Encyclopedia of Genetics: Second Edition / Maloy, Stanley R.; Hughes, Kelly T. 2013, pp. 501 - 503
    Online Full Text: dx.doi.org/
  • Kaiser, Markus; Groll, Michael; Götz, M.; Siciliano, C.; Assfalg-Machleidt, Irmgard; Weyer, E.; Kohno, J.; Milbradt, Alexander; Renner, Christian; Huber, Robert; Moroder, Luis
    Structural determinants for 20S proteasome inhibition by TMC-95A
    In: Peptides 2004 : bridges between disciplines ; proceedings of the Third International and Twenty-Eighth European Peptide Symposium, September 5 - 10, 2004, Prague, Czech Republic / Flegel, Martin (Eds.) 2004, pp. 657 - 658