ZMB Member Robert Huber
ZMB Member
Robert Huber
Next ZMB-Member
Prof. Dr. Dr. h.c. mult. Robert Huber FRS
Group
Structure ResearchCenter of Medical Biotechnology
Room: S03 S02 A45
University of Duisburg-Essen
45141 Essen
Max Planck Institute of Biochemistry
Am Klopferspitz 18
82152 Martinsried
- +49 201 183 4141
- Website
- Selected Publications
- Publication Metrics
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- ZMB Research Program
Molecular and Chemical Cell Biology
Research Overview
Professional interests
Structure and function of biological macromolecules, in particular those of large complex aggregates.
Systems studied
- Proteases and their natural and synthetic inhibitors.
- Metalloenzymes (iron, nickel, molybdenum, copper).
- Proteins of the immune system (antibodies and antibody receptors).
- Protein hormones and their receptors.
- Protein kinases.
- Proteins of amino acid biosynthesis (PLP containing enzymes).
- Proteins of cofactor and vitamin biosynthesis.
- Proteins of energy and electron transport.
Methods development
- Patterson methods in crystallography.
- Methods of structure determination of proteins and protein ligand complexes by NMR.
- Synthesis and use of electron rich metal clusters.
- Crystal annealing and improvement, methods and instruments.
- Analysis and evaluation of targets for research and application in pharmacology and crop science.
Selected Publications
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Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assembliesIn: Science Advances Vol. 7 (2021) Nr. 2, pp. eabd4413
ISSN: 2375-2548Online Full Text: dx.doi.org/ (Open Access) -
Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signalingIn: Proceedings of the National Academy of Sciences of the United States of America Vol. 111 (2014) Nr. 46, pp. 16496 - 16501
ISSN: 1091-6490; 0027-8424Online Full Text: dx.doi.org/ -
Differential global structural changes in the core particle of yeast and mouse proteasome induced by ligand bindingIn: Proceedings of the National Academy of Sciences of the United States of America Vol. 111 (2014) Nr. 26, pp. 9479 - 9484
ISSN: 1091-6490; 0027-8424Online Full Text: dx.doi.org/ -
Structural analysis of the human fibroblast growth factor receptor 4 kinaseIn: Journal of Molecular Biology Vol. 426 (2014) Nr. 22, pp. 3744 - 3756
ISSN: 1089-8638; 0022-2836Online Full Text: dx.doi.org/ -
Structural and Functional Analysis of the Natural JNK1 Inhibitor QuercetagetinIn: Journal of Molecular Biology Vol. 425 (2013) Nr. 2, pp. 411 - 423
ISSN: 1089-8638; 0022-2836Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
“How I Chose Research on Proteases or, More Correctly, How it Chose Me”In: Angewandte Chemie International Edition Vol. 52 (2013) Nr. 1, pp. 68 - 73
ISSN: 1521-3773Online Full Text: dx.doi.org/ -
Chemical Biology Approaches Reveal Conserved Features of a C-Terminal Processing PDZ ProteaseIn: ChemBioChem Vol. 13 (2012) Nr. 3, pp. 402 - 408
ISSN: 1439-4227; 1439-7633Online Full Text: dx.doi.org/ -
Hydroxyureas as noncovalent proteasome inhibitorsIn: Angewandte Chemie International Edition Vol. 51 (2012) Nr. 1, pp. 247 - 249
ISSN: 1521-3773Online Full Text: dx.doi.org/ -
Elucidation of the α-keto-aldehyde binding mechanism : A lead structure motif for proteasome inhibitionIn: Angewandte Chemie International Edition Vol. 50 (2011) Nr. 2, pp. 542 - 544
ISSN: 1521-3773Online Full Text: dx.doi.org/ -
HTRA proteases : regulated proteolysis in protein quality controlIn: Nature Reviews Molecular Cell Biology Vol. 12 (2011) Nr. 3, pp. 152 - 162
ISSN: 1471-0072Online Full Text: dx.doi.org/ -
Molecular architecture of the Spire-actin nucleus and its implication for actin filament assemblyIn: Proceedings of the National Academy of Sciences of the United States of America Vol. 108 (2011) Nr. 49, pp. 19575 - 19580
ISSN: 1091-6490; 0027-8424Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Protein quality control in the bacterial periplasmIn: Annual Review of Microbiology Vol. 65 (2011) pp. 149 - 168
ISSN: 1545-3251; 0066-4227Online Full Text: dx.doi.org/ -
The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binderIn: Journal of Molecular Biology Vol. 412 (2011) Nr. 2, pp. 251 - 266
ISSN: 0022-2836; 1089-8638Online Full Text: dx.doi.org/ -
Conversion of a regulatory into a degradative proteaseIn: Journal of Molecular Biology Vol. 397 (2010) Nr. 4, pp. 957 - 966
ISSN: 0022-2836; 1089-8638Online Full Text: dx.doi.org/ -
Determinants of structural and functional plasticity of a widely conserved protease chaperone complexIn: Nature Structural & Molecular Biology Vol. 17 (2010) Nr. 7, pp. 837 - 843
ISSN: 1545-9993; 1545-9985Online Full Text: dx.doi.org/ -
HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cuesIn: Nature Structural & Molecular Biology Vol. 17 (2010) Nr. 7, pp. 844 - 852
ISSN: 1545-9993; 1545-9985Online Full Text: dx.doi.org/ -
Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3In: Proceedings of the National Academy of Sciences of the United States of America Vol. 106 (2009) Nr. 40, pp. 17223 - 17228
ISSN: 1091-6490; 0027-8424Online Full Text: dx.doi.org/ -
Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coliIn: Research in Microbiology Vol. 160 (2009) Nr. 9, pp. 660 - 666
ISSN: 0923-2508; 1769-7123Online Full Text: dx.doi.org/ -
Synthetic and structural studies on Syringolin A and B reveal critical determinants for selectivity and potency of proteasome inhibitionIn: Proceedings of the National Academy of Sciences of the United States of America Vol. 106 (2009) Nr. 16, pp. 6507 - 6512
ISSN: 1091-6490; 0027-8424 -
A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanismIn: Nature Vol. 452 (2008) pp. 755 - 758
ISSN: 0028-0836; 1476-4687 -
Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteinsIn: Proceedings of the National Academy of Sciences of the United States of America Vol. 22 (2008) pp. 7702 - 7707
ISSN: 1091-6490; 0027-8424 -
Navigation inside a protease: Substrate selection and product exit in the tricorn protease from Thermoplasma acidophilumIn: Journal of Molecular Biology Vol. 324 (2002) Nr. 5, pp. 1041 - 1050
ISSN: 0022-2836; 1089-8638Online Full Text: dx.doi.org/ -
The Core Structure of TMC-95A Is a Promising Lead for Reversible Proteasome InhibitionIn: Angewandte Chemie - International Edition Vol. 41 (2002) Nr. 5, pp. 780 - 783
ISSN: 0044-8249; 0570-0833; 1433-7851