Welcome to ZMB
Welcome to ZMB
The Center of Medical Biotechnology (ZMB) is an interdisciplinary scientific center of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.
News & Events
25 Jahre Essener Kolleg für Geschlechterforschung & Kick-off Institut für Geschlechtersensible Medizin
Das Essener Kolleg für Geschlechterforschung (EKfG), eine zentrale wissenschaftliche Einrichtung der Universität Duisburg-Essen und Knotenpunkt des Netzwerks Frauen- und Geschlechterforschung NRW, blickt auf mehr als 25 Jahre erfolgreiche Arbeit in der Geschlechterforschung und Nachwuchsförderung zurück. Das EKfG begeht das Jubiläum gemeinsam mit dem Auftakt des von den langjährigen Sprecherinnen des EKfG-Forschungsclusters "Biomedizinische Forschung und klinische Medizin" Prof. Dr. Anke Hinney und PD Dr. Andrea Kindler-Röhrborn neugegründeten Instituts für Geschlechtersensible Medizin an der Medizinischen Fakultät am 8. März 2024 und lädt dazu herzlich an das Universitätsklinikum Essen ein.
CRC1430 Guest Speaker Series
26.03.2024
Britta Trappmann, DOLCE - Dortmund Life Science Center, TU Dortmund
30.04.2024
Monilola Olayioye, Universität Stuttgart
04.06.2024
Silvia Vega Rubin de Celis, UK Essen
25.06.2024
Yogesh Kulathu, MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee
23.07.2024
Jacques Neefjes, Cell and Chemical Biology, Leiden University Medical Center
All events start at 5.15pm in room S05V01E69.
For further information please contact crc1430@uni-due.de.
Erwin L. Hahn Institute: Two Awards offered
[16.01.2024] In 2024, the Erwin L. Hahn Institute for Magnetic Resonance Imaging (ELH) will once again present the International Erwin L. Hahn Institute Award. The ELH honours groundbreaking publications by mid-career scientists in the research areas of the ELH. The prize is awarded for work that combines an innovative approach with scientific excellence, international visibility and a substantial contribution to ultra-high field magnetic resonance imaging. The prize is awarded in the categories BRAIN and BODY, each of which is endowed with EUR 2,500.
Press Releases 2024/2023
Therapie bei Pneumokokken-Meningitis Blockierte Mustererkennungsrezeptoren
[05.03.2024] Meningitis, eine Hirnhautentzündung, kann durch nichtinfektiöse Reize oder eine Infektion mit verschiedenen mikrobiellen Erregern, wie z. B. Pneumokokken (Gram-positive Bakterien) ausgelöst werden. Obwohl wirksame Antibiotika zur Verfügung stehen, können die entzündlichen Prozesse im Hirn zu neurologischen Folgeerscheinungen oder sogar zum Tod führen. Wissenschaftler:innen der Medizinischen Fakultät der Universität Duisburg-Essen (UDE) und des Universitätsklinikums Essen (UK Essen) haben in Kooperation mit Kolleg:innen der Ludwig-Maximilians-Universität (LMU) München und der Universität Greifswald nun untersucht, wie die Antibiotikatherapie bei einer solchen Infektion sinnvoll ergänzt werden kann. Ihre Laborversuche zeigen, dass die Blockade der Rezeptoren TLR2 und TLR13 dabei helfen kann, die schädlichen Entzündungsprozesse auszubremsen.
Onkologie und Wirkstoffforschung Gemeinsame Erfolge bei seltenem Magen-Darm-Krebs
[29.02.2024] Wie lassen sich gastrointestinale Stromatumoren (kurz: GIST) behandeln und neue Therapien entwickeln? Diesen Fragen gehen die Arbeitsgruppen von Prof. Dr. Daniel Rauh (TU Dortmund) und Prof. Dr. Sebastian Bauer (Westdeutsches Tumorzentrum, UK Essen sowie Medizinische Fakultät UDE) gemeinsam nach. Seit mehr als zehn Jahren kämpfen die Essener Onkologie und die Dortmunder Wirkstoffforschung gegen den seltenen Magen/Darm-Krebs GIST. Aktuelle Ergebnisse ihrer Zusammenarbeit wurden jetzt im Journal of Clinical Oncology und in Nature Communications veröffentlicht.
University Alliance Ruhr Important step towards excellence
[02.02.2024] With combined strength, the University Alliance Ruhr (UA Ruhr) has reached the second round of the Excellence Strategy competition: scientists from Ruhr-Universität Bochum, TU Dortmund University and the University of Duisburg-Essen are involved in a total of four research projects that can now submit a full application as a Cluster of Excellence. This promising interim result emphasises the potential of the cooperation between the three universities in the Ruhr region in order to jointly apply as a Cluster of Excellence in the coming year.
The research programme "REASONS - River Ecosystems in the Anthroposcene - sustainable scientific SOlutioNS", in which the University of Duisburg-Essen wants to develop a new, sustainable concept for the management of water bodies with the participation of scientists from Ruhr-Universität Bochum and other partners, was able to impress in the current selection round.
Neue Erkenntnisse zu Signalproteinen Wie sich Zellen bewegen
[01.02.2024] Den Forschungsgruppen um Prof. Dr. Perihan Nalbant (Zentrum für Medizinische Biotechnologie der UDE) und Dr. Leif Dehmelt (Chemie und Chemische Biologie, TU Dortmund) ist es gelungen, die Signale sichtbar zu machen, welche die Formänderungen in der Zellmigration steuern. Ihre Ergebnisse könnten helfen, die Metastasierung von Krebs besser zu verstehen. Die renommierten Fachjournale Nature Communications und Molecular Biology of the Cell haben berichtet.
Die Migration von Zellen ist entscheidend für viele Prozesse im Körper. Auch bei einer Immunantwort „migrieren Zellen in komplexen Geweben“, wie es fachsprachlich heißt. Sind die Mechanismen gestört, kann es zu einer unkontrollierten Zellwanderung kommen – beispielsweise, wenn Krebs streut.
Schwimmverhalten von Spermien Weichmacher verändern vorübergehend Beweglichkeit
[24.01.2024] Ungewollte Kinderlosigkeit betrifft in Deutschland zirka ein Drittel aller Paare zwischen 25 und 50 Jahren. Bei wiederum etwa einem Drittel sind die Ursachen dafür nicht geklärt. Insbesondere bei männlichen Fruchtbarkeitsstörungen stehen immer wieder sogenannte Weichmacher im Fokus, die in vielen Alltagsgegenständen wie Plastikflaschen, Trinkbecherbeschichtungen oder sogar Kassenbons enthalten sind. Die Arbeitsgruppe um Prof. Dr. Gunther Wennemuth von der Medizinischen Fakultät der UDE ging daher der Frage nach, wie sich Weichmacher auf Spermien auswirken. Sie konnte zeigen, dass diese vorübergehend die Beweglichkeit der Spermien verringern. Ihre Ergebnisse haben die Forschenden kürzlich in der Fachzeitschrift Exposure and Health veröffentlicht.
Exzellenzförderung für Essener Krebsexperten Neue Behandlungsperspektiven für Tumoren des Immunsystems
[23.01.2024] Die Deutsche Krebshilfe unterstützt Forschende der Medizinischen Fakultät der Universität Duisburg-Essen im Zuge ihres DKH-Exzellenzförderprogramms für etablierte Forschende bis 2028 mit rund einer Million Euro. Gefördert wird ein Projekt von Prof. Dr. Christian Reinhardt, Direktor der Klinik für Hämatologie und Stammzelltransplantation am Universitätsklinikum Essen. Seine Forschung zielt darauf ab, die Heilungschancen von Patient:innen zu verbessern, bei denen das diffuse großzellige B-Zell-Lymphom zu schweren Krankheitsversläufen führt. Die durch Krebs ausgelöste Vergrößerung der Lymphknoten ist die häufigste Lymphom-Erkrankung bei Erwachsenen.
Neues Mikroskop für Analyse von Immunzellen Sichtbar mehr Bewegung
[11.12.2023] Immunzellen bekämpfen Krankheitserreger oder entartete Zellen in der Krebsentstehung in unserem Körper und bewegen sich dafür durch Blut und Gewebe. Am falschen Ort jedoch können sie Schaden anrichten. Daher ist es sinnvoll, dieses Migrationsverhalten zu untersuchen und wenn nötig zu unterdrücken. Die bisherige Videomikroskopie erlaubt jedoch nur eine langsame Bewegungsanalyse einzelner Zellproben. Forschende der Universität Duisburg-Essen und des Leibniz-Instituts für Analytische Wissenschaften haben nun ein Mikroskop entwickelt, das 64 – künftig sogar 384 – Proben in kurzer Zeit beobachtet. Über ComplexEye (dt. etwa Facettenauge oder Komplexauge) berichtet nun Nature Communications.
Neue MERCUR-Förderungen Projekte zum Brückenbauen
[07.12.2023] Das Mercator Research Center Ruhr (MERCUR) bewilligt in seiner aktuellen Ausschreibungsrunde über 840.000 Euro für kooperative Forschungsprojekte innerhalb der Universitätsallianz Ruhr (UA Ruhr): Die UDE ist an allen Projekten beteiligt.
"Synthetic Nucleic Acid Systems" schlägt eine Brücke zwischen den Forschungsaktivitäten der Chemischen Biologie, Zellbiologie sowie DNA-Nanotechnologie an der UDE und der TU Dortmund. Das Team will so eine experimentelle und wissensbasierte Grundlage schaffen, um gemeinsam funktionale Nukleinsäuresysteme zu erforschen und neu zu gestalten. Nukleinsäuren spielen als genetischer Informationsträger, regulatorische Elemente, Bindungsplattformen und Katalysatoren in allen biologischen Systemen eine entscheidende Rolle.
1,5 Mio. Euro für Hautkrebsforschung ERC Starting Grant für Alpaslan Tasdogan
[07.12.2023] Europas führende Förderorganisation, der Europäische Forschungsrat (ERC), unterstützt die Hautkrebsforschung von Wissenschaftler:innen der Medizinischen Fakultät der UDE bis 2028 mit 1,5 Millionen Euro. Mit einem „ERC Starting Grant“ fördert das EU-Gremium den Onkologen und Dermatologen Prof. Dr. Dr. Alpaslan Tasdogan. Erstmals geht diese Förderung an einen in Essen tätigen Forscher. Ziel von Professor Tasdogan und seinem Team ist, durch Untersuchungen an Patient:innen besser zu verstehen, warum sich gesunde Zellen in Zellen des Schwarzen Hautkrebses verwandeln, im Körper streuen und wie diese Metastasen bekämpft werden können.
Research Magazine UDE
Focus: Health
Good Killer Cells
Chemotherapy, radiotherapy or surgery – these are the three common forms of cancer therapy. The lymphoma specialists at University Hospital Essen are investigating the possibility of a different approach.
Research Magazine UDE
Focus: Health
Please treat unequally
Height: just under 1.80 meters; weight: approximately 85 kilograms. One X and one Y chromosome. This has been more or less accepted as the norm in medical research – until now. Prof. Dr Anke Hinney is about to change that.
Research Magazine UDE
Focus: Health
One Health
What happens deep down in Earth’s subsurface? That’s the focus of Alexander Probst’s research. He also studies how microorganisms influence environmental health. The research professor at the new Research Center One Health Ruhr has declared war on antibiotic resistances.
08.03.2024 - 12:30:00
Zum Weltfrauentag 2024: Institut für Geschlechtersensible Medizin in Essen gegründet
05.03.2024 - 14:44:12
Therapie bei Pneumokokken-Meningitis: Blockierte Mustererkennungsrezeptoren
29.02.2024 - 11:00:16
Onkologie und Wirkstoffforschung: Gemeinsame Erfolge bei seltenem Magen-Darm-Krebs
ZMB Research Programs
Oncology
The concept of this research program is to understand fundamental processes in tumor biology in order to develop novel molecularly defined and rationally applied cancer treatments.
Participating researchers from biology, experimental and clinical medicine study tumors as “biological systems" and so called “neo-organs”.
A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumor development, growth, progression and tumor cell migration.
Immunology, Infectious Diseases and Transplantation
The immune system responds to various pathogens including viruses and bacteria in different ways to prevent severe disease and persistence in the host. Many pathogens, however, have developed mechanisms to evade immune defence.
The molecular and cellular interactions of pathogens with the immune system are studied within this program.
Molecular and Chemical Cell Biology
Molecular and chemical cell biology is an interdisciplinary research program connecting molecular cell biology and genetics with chemistry and structural biology. Scientists of the participating disciplines collaborate to advance the understanding of basic molecular mechanisms of important biological processes.
The analysis of regulation and deregulation of key pathways is linking basic biology with pathophysiology.
Latest Publications
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A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanomaIn: Cell Vol. 187 (2024) Nr. 1, pp. 166 - 183.e25Online Full Text: dx.doi.org/ (Open Access)
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Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRAIn: Nature Communications Vol. 15 (2024) Nr. 1, 63Online Full Text: dx.doi.org/ (Open Access)
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Ripretinib versus sunitinib in gastrointestinal stromal tumor : ctDNA biomarker analysis of the phase 3 INTRIGUE trialIn: Nature Medicine (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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Structure of the human KMN complex and implications for regulation of its assemblyIn: Nature Structural & Molecular Biology (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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Thirty years of structural changesIn: Nature Structural & Molecular Biology (2024) in pressOnline Full Text: dx.doi.org/
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TopBP1 utilises a bipartite GINS binding mode to support genome replicationIn: Nature Communications Vol. 15 (2024) Nr. 1, 1797Online Full Text: dx.doi.org/ (Open Access)
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XPO1-Mediated mRNA Export of Genome Maintenance Regulators Drives Chemotherapy Resistance in Aggressive LymphomaIn: Cancer Research Vol. 84 (2024) Nr. 1, pp. 3 - 5Online Full Text: dx.doi.org/
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A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in GlioblastomaIn: Clinical Cancer Research Vol. 29 (2023) Nr. 2, pp. 488 - 500Online Full Text: dx.doi.org/ (Open Access)
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Active Remodeling of Capillary Endothelium via Cancer Cell-Derived MMP9 Promotes Metastatic Brain ColonizationIn: Cancer Research Vol. 83 (2023) Nr. 8, pp. 1299 - 1314Online Full Text: dx.doi.org/
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Adjuvant immunotherapy with nivolumab versus observation in completely resected Merkel cell carcinoma (ADMEC-O) : disease-free survival results from a randomised, open-label, phase 2 trialIn: Lancet Vol. 402 (2023) Nr. 10404, pp. 798 - 808Online Full Text: dx.doi.org/
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Allogeneic hematopoietic stem cell transplantation for NK/T-cell lymphoma : An international collaborative analysisIn: Leukemia Vol. 37 (2023) Nr. 7, pp. 1511 - 1520Online Full Text: dx.doi.org/ (Open Access)
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Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencingIn: Nature Genetics Vol. 55 (2023) Nr. 6, 1076Online Full Text: dx.doi.org/ (Open Access)
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Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancersIn: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1078Online Full Text: dx.doi.org/ (Open Access)
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Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancerIn: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1079Online Full Text: dx.doi.org/ (Open Access)
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Author Correction: Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesisIn: Nature Communications Vol. 14 (2023) Nr. 1, pp. 2675Online Full Text: dx.doi.org/ (Open Access)
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Author Correction: Pan-cancer analysis of whole genomesIn: Nature Vol. 614 (2023) Nr. 7948, pp. E39Online Full Text: dx.doi.org/ (Open Access)
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Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotranspositionIn: Nature Genetics Vol. 55 (2023) Nr. 6, 1080Online Full Text: dx.doi.org/ (Open Access)
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Author Correction: The landscape of viral associations in human cancersIn: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1077Online Full Text: dx.doi.org/ (Open Access)
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Baseline PET radiomics outperforms the IPI risk score for prediction of outcome in diffuse large B-cell lymphomaIn: Blood Vol. 141 (2023) Nr. 25, pp. 3055 - 3064Online Full Text: dx.doi.org/ (Open Access)
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Chirality control of a single carbene molecule by tip-induced van der Waals interactionsIn: Nature Communications Vol. 14 (2023) Nr. 1, 4500Online Full Text: dx.doi.org/ (Open Access)
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Circulating tumor DNA analysis of the phase III VOYAGER trial : KIT mutational landscape and outcomes in patients with advanced gastrointestinal stromal tumor treated with avapritinib or regorafenibIn: Annals of Oncology Vol. 34 (2023) Nr. 7, pp. 615 - 625Online Full Text: dx.doi.org/
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Clp-targeting BacPROTACs impair mycobacterial proteostasis and survivalIn: Cell Vol. 186 (2023) Nr. 10, pp. 2176 - 2192.e22Online Full Text: dx.doi.org/ (Open Access)
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Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcriptionIn: Science Advances Vol. 9 (2023) Nr. 41, eadg5109Online Full Text: dx.doi.org/ (Open Access)
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ComplexEye : a multi-lens array microscope for high-throughput embedded immune cell migration analysisIn: Nature Communications Vol. 14 (2023) Nr. 1, 8103Online Full Text: dx.doi.org/ (Open Access)
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Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencingIn: Nature Genetics Vol. 52 (2023) pp. 331 - 341Online Full Text: dx.doi.org/ (Open Access)
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Comprehensive molecular characterization of mitochondrial genomes in human cancersIn: Nature Genetics Vol. 52 (2023) pp. 342 - 352Online Full Text: dx.doi.org/ (Open Access)
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Correction: “The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms” Leukemia. 2022 Jul;36(7):1720–1748In: Leukemia Vol. 37 (2023) Nr. 9, pp. 1944 - 1951Online Full Text: dx.doi.org/ (Open Access)
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Data-driven grading of acute graft-versus-host diseaseIn: Nature Communications Vol. 14 (2023) Nr. 1, 7799Online Full Text: dx.doi.org/ (Open Access)
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Decrypting drug actions and protein modifications by dose- and time-resolved proteomicsIn: Science Vol. 380 (2023) Nr. 6640, pp. 93 - 101Online Full Text: dx.doi.org/
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Determinants of resistance to engineered T cell therapies targeting CD19 in large B cell lymphomasIn: Cancer Cell Vol. 41 (2023) Nr. 1, pp. 210 - 225.e5Online Full Text: dx.doi.org/
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Differentiating between Acidic and Basic Surface Hydroxyls on Metal Oxides by Fluoride Substitution : A Case Study on Blue TiO₂ from Laser Defect EngineeringIn: Angewandte Chemie International Edition Vol. 62 (2023) Nr. 12, e202213968Online Full Text: dx.doi.org/ (Open Access)
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Disruption of chromatin folding domains by somatic genomic rearrangements in human cancerIn: Nature Genetics Vol. 52 (2023) Nr. 3, pp. 294 - 305Online Full Text: dx.doi.org/ (Open Access)
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Dynamics and durability of HIV-1 neutralization are determined by viral replicationIn: Nature Medicine Vol. 29 (2023) Nr. 11, pp. 2763 - 2774Online Full Text: dx.doi.org/ (Open Access)
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Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNAIn: Blood (2023) in pressOnline Full Text: dx.doi.org/
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Erdafitinib in patients with advanced solid tumours with FGFR alterations (RAGNAR) : An international, single-arm, phase 2 studyIn: The Lancet Oncology Vol. 24 (2023) Nr. 8, pp. 925 - 935Online Full Text: dx.doi.org/
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Extracorporeal Life Support in Infarct-Related Cardiogenic ShockIn: The New England Journal of Medicine Vol. 389 (2023) Nr. 14, pp. 1286 - 1297Online Full Text: dx.doi.org/
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Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapyIn: Blood Vol. 142 (2023) Nr. 25, pp. 2175 - 2191Online Full Text: dx.doi.org/ (Open Access)
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HLA class II loss and JAK1/2 deficiency coevolve in melanoma leading to CD4 T cell and IFNγ cross-resistanceIn: Clinical Cancer Research Vol. 29 (2023) Nr. 15, pp. 2894 - 2907Online Full Text: dx.doi.org/
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Hemizygous CDKN2A deletion confers worse survival outcomes in IDHmut-noncodel gliomasIn: Neuro-Oncology Vol. 25 (2023) Nr. 9, pp. 1721 - 1723Online Full Text: dx.doi.org/ (Open Access)
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Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesisIn: Nature Communications Vol. 14 (2023) Nr. 1, 2275Online Full Text: dx.doi.org/ (Open Access)
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Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s diseaseIn: Nature Communications Vol. 14 (2023) Nr. 1, 1631Online Full Text: dx.doi.org/ (Open Access)
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Impact of TP53 on outcome of patients with myelofibrosis undergoing hematopoietic stem cell transplantationIn: Blood Vol. 141 (2023) Nr. 23, pp. 2901 - 2911Online Full Text: dx.doi.org/
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Impact of bimetallic interface design on heat generation in plasmonic Au/Pd nanostructures studied by single-particle thermometryIn: Nature Communications Vol. 14 (2023) Nr. 1, 3813Online Full Text: dx.doi.org/ (Open Access)
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Impaired humoral immunity to BQ.1.1 in convalescent and vaccinated patientsIn: Nature Communications Vol. 14 (2023) Nr. 1, 2835Online Full Text: dx.doi.org/ (Open Access)
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Importance of broken geometric symmetry of single-atom Pt sites for efficient electrocatalysisIn: Nature Communications Vol. 14 (2023) Nr. 1, 3233Online Full Text: dx.doi.org/ (Open Access)
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Individual glioblastoma cells harbor both proliferative and invasive capabilities during tumor progressionIn: Neuro-Oncology Vol. 25 (2023) Nr. 12, pp. 2150 - 2162Online Full Text: dx.doi.org/
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Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytomaIn: Acta Neuropathologica Vol. 149 (2023) Nr. 4, pp. 551 - 564Online Full Text: dx.doi.org/ (Open Access)
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Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancerIn: Gut Vol. 72 (2023) Nr. 6, pp. 1174 - 1185Online Full Text: dx.doi.org/
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KIT and PDGFRA Mutations and Survival of Gastrointestinal Stromal Tumor Patients Treated with Adjuvant Imatinib in a Randomized TrialIn: Clinical Cancer Research Vol. 29 (2023) Nr. 17, pp. 3313 - 3319Online Full Text: dx.doi.org/ (Open Access)
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LAMC2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer GrowthIn: Clinical Cancer Research Vol. 29 (2023) Nr. 6, pp. 1137 - 1154Online Full Text: dx.doi.org/
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Marine viruses disperse bidirectionally along the natural water cycleIn: Nature Communications Vol. 14 (2023) Nr. 1, 6354Online Full Text: dx.doi.org/ (Open Access)
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Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancerIn: Nature Vol. 615 (2023) Nr. 7950, pp. 168 - 174Online Full Text: dx.doi.org/ (Open Access)
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Molecular heterogeneity and commonalities in pancreatic cancer precursors with gastric and intestinal phenotypeIn: Gut Vol. 72 (2023) Nr. 3, pp. 522 - 534Online Full Text: dx.doi.org/ (Open Access)
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Neoadjuvant immunotherapy for melanoma is now ready for clinical practiceIn: Nature Medicine Vol. 29 (2023) Nr. 6, pp. 1310 - 1312Online Full Text: dx.doi.org/
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Neutrophil Conversion to a Tumor-Killing Phenotype Underpins Effective Microbial TherapyIn: Cancer Research Vol. 83 (2023) Nr. 8, pp. 1315 - 1328Online Full Text: dx.doi.org/ (Open Access)
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Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotranspositionIn: Nature Genetics Vol. 52 (2023) Nr. 3, pp. 306 - 319Online Full Text: dx.doi.org/ (Open Access)
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Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identificationIn: Nature Communications Vol. 14 (2023) Nr. 1, pp. 4632Online Full Text: dx.doi.org/ (Open Access)
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RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore coronaIn: The EMBO Journal Vol. 42 (2023) Nr. 24, e114838Online Full Text: dx.doi.org/
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Resting natural killer cell homeostasis relies on tryptophan/NAD⁺ metabolism and HIF-1αIn: EMBO Reports (2023) e56156Online Full Text: dx.doi.org/ (Open Access)
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Rho GTPase activity crosstalk mediated by Arhgef11 and Arhgef12 coordinates cell protrusion-retraction cyclesIn: Nature Communications Vol. 14 (2023) Nr. 1, 8356Online Full Text: dx.doi.org/ (Open Access)
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Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and PentamerIn: Immunity Vol. 56 (2023) Nr. 11, pp. 2602 - 2620.e10Online Full Text: dx.doi.org/
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Sotorasib in KRAS p.G12C-Mutated Advanced Pancreatic CancerIn: The New England Journal of Medicine Vol. 388 (2023) Nr. 1, pp. 33 - 43Online Full Text: dx.doi.org/
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Sotorasib versus docetaxel for previously treated non-small-cell lung cancer with KRASG¹²C mutation : a randomised, open-label, phase 3 trialIn: Lancet Vol. 401 (2023) Nr. 10378, pp. 733 - 746Online Full Text: dx.doi.org/
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Spermine and spermidine bind CXCR4 and inhibit CXCR4- but not CCR5-tropic HIV-1 infectionIn: Science Advances Vol. 9 (2023) Nr. 27, eadf8251Online Full Text: dx.doi.org/ (Open Access)
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Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophyIn: Acta Neuropathologica Vol. 145 (2023) Nr. 5, pp. 611 - 635Online Full Text: dx.doi.org/ (Open Access)
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Stable kinetochore-microtubule attachment requires loop-dependent Ndc80-Ndc80 bindingIn: The EMBO Journal Vol. 42 (2023) Nr. 13, e112504Online Full Text: dx.doi.org/ (Open Access)
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Structural basis of ubiquitin-independent PP1 complex disassembly by p97In: The EMBO Journal Vol. 42 (2023) Nr. 14, e113110Online Full Text: dx.doi.org/ (Open Access)
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Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrateIn: Nature Communications Vol. 14 (2023) Nr. 1, 5942Online Full Text: dx.doi.org/ (Open Access)
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The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunityIn: Cancer Cell Vol. 41 (2023) Nr. 7, pp. 1207 - 1221.e12Online Full Text: dx.doi.org/
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The German Network for Personalized Medicine to enhance patient care and translational researchIn: Nature Medicine Vol. 29 (2023) Nr. 6, pp. 1298 - 1301Online Full Text: dx.doi.org/
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The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPaseIn: Nature Communications Vol. 14 (2023) Nr. 1, 3258Online Full Text: dx.doi.org/ (Open Access)
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The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latencyIn: Cell Reports Vol. 42 (2023) Nr. 11, 113285Online Full Text: dx.doi.org/ (Open Access)
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The landscape of viral associations in human cancersIn: Nature Genetics (2023) Nr. 52, pp. 320 - 330Online Full Text: dx.doi.org/ (Open Access)
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The optimal healthy ranges of thyroid function defined by the risk of cardiovascular disease and mortality : systematic review and individual participant data meta-analysisIn: The Lancet Diabetes and Endocrinology Vol. 11 (2023) Nr. 10, pp. 743 - 754Online Full Text: dx.doi.org/
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The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint ComplexIn: Nature Communications Vol. 14 (2023) Nr. 1, 1529Online Full Text: dx.doi.org/ (Open Access)
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The transcriptional and regulatory identity of erythropoietin producing cellsIn: Nature Medicine Vol. 29 (2023) Nr. 5, pp. 1191 - 1200Online Full Text: dx.doi.org/
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Transcriptional reprogramming by mutated IRF4 in lymphomaIn: Nature Communications Vol. 14 (2023) Nr. 1, 6947Online Full Text: dx.doi.org/ (Open Access)
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Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responsesIn: Immunity Vol. 56 (2023) Nr. 6, pp. 1341 - 1358.e11Online Full Text: dx.doi.org/ (Open Access)
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Tuning the Electronic Properties of Platinum in Hybrid-Nanoparticle Assemblies for use in Hydrogen Evolution ReactionIn: Angewandte Chemie International Edition Vol. 62 (2023) Nr. 25, e202301065Online Full Text: dx.doi.org/ (Open Access)
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Zoledronic Acid Add-on Therapy for Standard-Risk Ewing Sarcoma Patients in the Ewing 2008R1 TrialIn: Clinical Cancer Research Vol. 29 (2023) Nr. 24, pp. 5057 - 5068Online Full Text: dx.doi.org/