Welcome to ZMB
Welcome to ZMB
The Center of Medical Biotechnology (ZMB) is an interdisciplinary scientific center of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.
News & Events
March 4—6, 2026 17th German Peptide Symposium
Join us for the 17th German Peptide Symposium, which will take place March 4—6, 2026, on the UDE campus in Essen.
The 17th German Peptide Symposium 2026 is an open-topic conference on all aspects of modern peptide chemistry. The symposium will feature plenary and keynote lectures and poster sessions, providing a platform for early-career scientists and established experts to exchange knowledge, discuss the latest developments in peptide science, and explore potential applications in biomedicine, biotechnology, and materials sciences. We look forward to your participation. Registration is now open!
Congratulations! Five ZMB Members Received the ‘Highly Cited Researchers Awards 2025’
Congratulations to our members Alexander Probst, Dirk Schadendorf, Bernd Giebel, Ken Herrmann, and Martin Schuler on being named Highly Cited Researchers 2025.
This designation reflects the sustained influence of their scientific work and the relevance their findings have gained within their fields.
It also signals the level of expertise represented in the ZMB's network, where strong basic, clinical, and translational research come together in a way that contributes to successful scientific progress.
CRC1430 Guest Speaker Series
09.12.2025
Christian Ungermann
Center of Cellular Nanoanalytics, Osnabrueck University
Press Releases 2025
Internationally Influential and Recognised UDE researchers are highly cited
[17.11.2025] Seven researchers have received the ‘Highly Cited Researchers Awards 2025’ – an important signal for the international visibility and influence of research at the University of Duisburg-Essen. The award honours scientists whose publications are cited particularly frequently and who have also met other important scientific quality criteria over a period of eleven years. According to the Institute of Scientific Information at Clarivate Analytics, those included in this list are among the 6,868 people worldwide who have the greatest scientific influence.
ZMB Member: Prof. Dr. Alexander Probst
ZMB Member: Prof. Dr. Dirk Schadendorf
ZMB Member: Prof. Dr. Bernd Giebel
ZMB Member: Prof. Dr. Ken Herrmann
ZMB Member: Prof. Dr. Martin Schuler
Förderung für Tumorforschung Bessere Therapie gegen Krebs des oberen Verdauungstrakts
[13.11.2025]
Ein internationales Forschungsteam geht neue Wege im Kampf gegen Krebs des oberen Verdauungstrakts. Maßgeblich daran beteiligt sind Wissenschaftler:innen der Medizinischen Fakultät der Universität Duisburg-Essen. In ihrem Fokus stehen sogenannte Radionuklid-Theranostika. Das sind Medikamente, die Krebszellen gleichzeitig aufspüren und mit gezielter Strahlung zerstören können. Sie sollen in Zukunft auch bei Krebs des oberen Verdauungstrakts eingesetzt werden. Gefördert wird das Vorhaben von „Stand Up To Cancer“ für 18 Monate bis März 2027 mit rund 357.000 Euro. Rund 200.000 Euro fließen an die Forschenden in Essen.
ZMB Member: Prof. Dr. Ken Herrmann
ZMB Member: Prof. Dr. Katharina Lückerath
5. Tag der Forschungsdaten in NRW FAIRe Daten – FAIR Play
[10.11.2025]
Unter dem Motto „FAIRe Daten – FAIR Play: Alles eine Frage der Aufstellung“ laden die Research Data Services (RDS) der UDE am 18. November zum 5. NRW-weiten Tag der Forschungsdaten mit einem abwechslungsreichen Programm ein.
Ab 10 Uhr übertragen wir im Bibliothekssaal am Campus Essen das Vormittagsprogramm der Landesinitiative fdm.nrw: In einer Podiumsdiskussion sprechen vier Forschende über ihre Arbeit in den Konsortien der nationalen Forschungsdateninfrastruktur (NFDI) – über Impact, über Beteiligungsmöglichkeiten und über die Zukunft des Forschungsdatenmanagements (FDM).
ZMB Member: Prof. Dr. Ralf Küppers
Else Kröner-Fresenius-Stiftung funds a novel approach to targeted protein degradation A New Path in Personalized Cancer Therapy through Nanobody PROTACs
[13.10.2025]
Else Kröner-Fresenius-Stiftung will fund a new research project starting in October 2025 that explores tumor-specific protein degradation strategies. The goal is to develop novel therapeutic approaches for head and neck cancers, including laryngeal carcinoma.
The team led by Dr. Mike Blüggel at the Center of Medical Biotechnology (ZMB) is developing tailored nanobody-based PROTACs designed to selectively target the survival enzyme Survivin. Survivin plays a central role in the development of various cancers and contributes to resistance against radiation and chemotherapy. To date, it has remained difficult to reach therapeutically.
ZMB Member: Prof. Dr. Shirley Knauer
Research project on leukaemia in children A new, twofold approach
[13.10.2025]
Scientists at the University of Duisburg-Essen are researching new therapies for aggressive forms of childhood leukaemia. For the first time, their approach tries to distinguish between two subtypes using so-called nanobody PROTACs. These attack diseased tissue while sparing healthy cells. The José Carreras Leukaemia Foundation is supporting the project, led by Prof. Dr. Shirley Knauer and Dr. Mike Blueggel from the Faculty of Biology, with 143,740 euros for two years.
ZMB Member: Prof. Dr. Shirley Knauer
New roadmap in Nature Microbiology Fair Rules for Sharing Sequence Data
[26.09.2025]
DNA and RNA datasets in public repositories are expanding at an unprecedented pace, creating a global atlas of microbial diversity. While open access continues to drive research forward, it also presents a dilemma: painstakingly collected data are often made available worldwide before the researchers who generated them can publish their own findings. In response, an international consortium of more than 230 scientists, led by Professor Alexander Probst of the University of Duisburg-Essen, has published a roadmap in Nature Microbiology to promote fairer handling of public sequence data.
ZMB Member: Prof. Dr. Alexander Probst
04.12.2025 - 11:00:00
Organschäden nach Mangeldurchblutung: Förderung für Zelltod-Forschung verlängert
04.12.2025 - 09:00:00
Europäische Konferenz zur organspezifischen Schilddrüsenhormonwirkung in Essen
03.12.2025 - 11:15:00
Netzwerk spanischer Forschender im Ausland unterstützt Dr. Silvia Vega-Rubín-de-Celis
ZMB Research Programs
Oncology
The concept of this research program is to understand fundamental processes in tumor biology in order to develop novel molecularly defined and rationally applied cancer treatments.
Participating researchers from biology, experimental and clinical medicine study tumors as “biological systems" and so called “neo-organs”.
A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumor development, growth, progression and tumor cell migration.
Immunology, Infectious Diseases and Transplantation
The immune system responds to various pathogens including viruses and bacteria in different ways to prevent severe disease and persistence in the host. Many pathogens, however, have developed mechanisms to evade immune defence.
The molecular and cellular interactions of pathogens with the immune system are studied within this program.
Molecular and Chemical Cell Biology
Molecular and chemical cell biology is an interdisciplinary research program connecting molecular cell biology and genetics with chemistry and structural biology. Scientists of the participating disciplines collaborate to advance the understanding of basic molecular mechanisms of important biological processes.
The analysis of regulation and deregulation of key pathways is linking basic biology with pathophysiology.
Latest Publications
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A mouse model of cardiac immunoglobulin light chain amyloidosis reveals insights into tissue accumulation and toxicity of amyloid fibrilsIn: Nature Communications, Vol. 16, 2025, Nr. 1, 2992DOI (Open Access)
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ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chainsIn: The EMBO Journal, Vol. 44, 2025, Nr. 18, pp. 5086 – 5111DOI (Open Access)
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Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment strategy for schizophreniaIn: Molecular Psychiatry, Vol. 30, 2025, Nr. 7, pp. 2891 – 2906DOI (Open Access)
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Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunityIn: Cancer Cell, Vol. 43, 2025, Nr. 2, pp. 269 – 291.e19DOI (Open Access)
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Adjuvant nivolumab and relatlimab in stage III/IV melanoma : the randomized phase 3 RELATIVITY-098 trialIn: Nature Medicine, 2025, in pressDOI (Open Access)
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Approaches to stable isotope tracing and in vivo metabolomics in the cancer clinicIn: The EMBO Journal, Vol. 44, 2025, Nr. 12, pp. 3303 – 3306DOI (Open Access)
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Aspartate signalling drives lung metastasis via alternative translationIn: Nature, Vol. 638, 2025, Nr. 2, pp. 244 – 250
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Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidationIn: Nature Communications, Vol. 16, 2025, Nr. 1, 1774DOI, Online Full Text (Open Access)
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Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trialIn: Nature Medicine, Vol. 31, 2025, Nr. 1, pp. 152 – 164DOI (Open Access)
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Bacterial pathogen deploys the iminosugar glycosyrin to manipulate plant glycobiologyIn: Science, Vol. 388, 2025, Nr. 6744, pp. 297 – 303
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CCooperative Active Sites on Ag2Pt3TiS6 for Enhanced Low-Temperature Ammonia Fuel Cell ElectrocatalysisIn: Angewandte Chemie International Edition, Vol. 64, 2025, Nr. 6, e202418691 , in pressDOI (Open Access)
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CEACAM1 as a mediator of B-cell receptor signaling in mantle cell lymphomaIn: Nature Communications, Vol. 16, 2025, Nr. 1, 4967DOI (Open Access)
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CSF1R⁺ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphomaIn: Cancer Cell, Vol. 43, 2025, Nr. 8, pp. 1476 – 1494.e10DOI (Open Access)
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Clinical validation of droplet digital PCR assays in detecting BRAFV⁶⁰⁰-mutant circulating tumour DNA as a prognostic biomarker in patients with resected stage III melanoma receiving adjuvant therapy (COMBI-AD) : A biomarker analysis from a double-blind, randomised phase 3 trialIn: The Lancet Oncology, Vol. 26, 2025, Nr. 5, pp. 641 – 653
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Common hereditary variants of the APOE gene and posttransplant outcome in acute myeloid leukemiaIn: Blood, Vol. 145, 2025, Nr. 17, pp. 1943 – 1956
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Common origin and somatic mutation patterns of composite lymphomas and leukemiasIn: Leukemia, Vol. 39, 2025, Nr. 8, pp. 1960 – 1971DOI (Open Access)
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Conformational plasticity of a BiP-GRP94 chaperone complexIn: Nature Structural & Molecular Biology, Vol. 32, 2025, Nr. 10, pp. 1947 – 1958DOI (Open Access)
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Constitutive expression of the transcriptional co-activator IκBζ promotes melanoma growth and immunotherapy resistanceIn: Nature Communications, Vol. 16, 2025, Nr. 1, 5387DOI (Open Access)
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Cutaneous melanoma : ESMO Clinical Practice Guideline for diagnosis, treatment and follow-upIn: Annals of Oncology, Vol. 36, 2025, Nr. 1, pp. 10 – 30
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Diet modulates the therapeutic effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCAR2In: eLife, Vol. 14, 2025, e98970DOI (Open Access)
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Discordance, accuracy and reproducibility study of pathologists’ diagnosis of melanoma and melanocytic tumorsIn: Nature Communications, Vol. 16, 2025, Nr. 1, 789DOI (Open Access)
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Exercise facilitates post-stroke recovery through mitigation of neuronal hyperexcitability via interleukin-10 signalingIn: Nature Communications, Vol. 16, 2025, Nr. 1, 8928DOI (Open Access)
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Final overall survival and safety analyses of the phase III PSMAfore trial of [¹⁷⁷Lu]Lu-PSMA-617 versus change of androgen receptor pathway inhibitor in taxane-naive patients with metastatic castration-resistant prostate cancerIn: Annals of Oncology, Vol. 36, 2025, Nr. 11, pp. 1319 – 1330DOI (Open Access)
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Final, 10-Year Outcomes with Nivolumab plus Ipilimumab in Advanced MelanomaIn: The New England Journal of Medicine, Vol. 392, 2025, Nr. 1, pp. 11 – 22DOI, Online Full Text (Open Access)
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Fulminant myocarditis : outcome predictors in an international cohort studyIn: European Heart Journal, 2025, in press
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Functional synapses between neurons and small cell lung cancerIn: Nature, Vol. 646, 2025, Nr. 8087, pp. 1243 – 1253DOI (Open Access)
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Gemtuzumab ozogamicin in first-line treatment of CBF-AML : Insights from a retrospective multi-center analysisIn: Leukemia, Vol. 39, 2025, Nr. 9, pp. 2174 – 2180DOI (Open Access)
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Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulationIn: Molecular Psychiatry, Vol. 30, 2025, Nr. 5, pp. 1836 – 1846DOI (Open Access)
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Genetic lesions in nodular lymphocyte-predominant Hodgkin lymphoma and T cell/histiocyte-rich large B-cell lymphoma identified by whole genome sequencingIn: Leukemia, Vol. 39, 2025, Nr. 9, pp. 2215 – 2225DOI (Open Access)
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HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replicationIn: Journal of Hepatology, Vol. 82, 2025, Nr. 5, pp. 805 – 815DOI (Open Access)
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High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non-Small Cell Lung Cancer in PatientsIn: Cancer Discovery, Vol. 15, 2025, Nr. 4, pp. 702 – 716DOI (Open Access)
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Hypoxic-ischemic brain injury in neonatal mice sequentially recruits neutrophils with dichotomous phenotype and functionIn: Nature Communications, Vol. 16, 2025, Nr. 1, 9696DOI (Open Access)
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IL-10 sensing by lung interstitial macrophages prevents bacterial dysbiosis-driven pulmonary inflammation and maintains immune homeostasisIn: Immunity, Vol. 58, 2025, Nr. 5, pp. 1306 – 1326.e7DOI (Open Access)
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Identification of Ni–N₄ Active Sites in Atomically Dispersed Ni Catalysts for Efficient Chlorine Evolution ReactionIn: Journal of the American Chemical Society: JACS, Vol. 147, 2025, Nr. 31, pp. 27664 – 27675DOI (Open Access)
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Immune training enhances anti-viral responses and improves outcomes in Pax5−/⁺ mice susceptible to chronic infectionIn: EMBO Molecular Medicine, Vol. 17, 2025, Nr. 4, pp. 696 – 721DOI (Open Access)
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Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis and correlate with thrombus resolutionIn: Immunity, Vol. 58, 2025, Nr. 5, pp. 1343 – 1358.e13DOI (Open Access)
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In situ Cyclization of Aromatic Thioethers in Emissive Materials to Generate Phosphorescent DibenzothiophenesIn: Angewandte Chemie International Edition, Vol. 64, 2025, Nr. 2, e202414326DOI (Open Access)
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Influence of Resuscitated Cardiac Arrest on Efficacy and Safety of Extracorporeal Life Support in Infarct-Related Cardiogenic Shock : A Substudy of the ECLS-SHOCK TrialIn: Circulation, Vol. 151, 2025, Nr. 24, pp. 1752 – 1754
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Intermetallic Platinum-Calcium Alloy Breaks the Activity-Stability Trade-Off in Fuel Cell for Enhanced PerformanceIn: Small, Vol. 21, 2025, Nr. 31, 2503692DOI (Open Access)
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Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complexIn: Nature Communications, Vol. 16, 2025, Nr. 1, 4823DOI (Open Access)
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Lack of AtMC1 catalytic activity triggers autoimmunity dependent on NLR stabilityIn: EMBO Reports, Vol. 26, 2025, Nr. 9, pp. 2378 – 2412DOI (Open Access)
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Lymphoma accelerates T cell and tissue agingIn: Cancer Cell, Vol. 43, 2025, Nr. 10, pp. 1917 – 1936.e8DOI (Open Access)
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MXenes Spontaneously Form Active and Selective Single-Atom Centers under Anodic Polarization ConditionsIn: Journal of the American Chemical Society: JACS, Vol. 147, 2025, Nr. 1, pp. 161 – 168DOI (Open Access)
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Molecular Tweezers Block the Functional Pore of a Protein MachineIn: Journal of the American Chemical Society: JACS, Vol. 147, 2025, Nr. 20, pp. 16836 – 16849DOI (Open Access)
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Molecular determinants of sotorasib clinical efficacy in KRASG12C-mutated non-small-cell lung cancerIn: Nature Medicine, Vol. 31, 2025, Nr. 8, pp. 2755 – 2767DOI (Open Access)
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Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicityIn: Nature Communications, Vol. 16, 2025, Nr. 1, 2110DOI (Open Access)
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Multistate kinetics of the syringe-like injection mechanism of Tc toxinsIn: Science Advances, Vol. 11, 2025, Nr. 1, eadr2019DOI (Open Access)
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Muscle growth by sarcomere divisionsIn: Science Advances, Vol. 11, 2025, Nr. 28, eadw9445DOI (Open Access)
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Neoadjuvant intralesional targeted immunocytokines (daromun) in stage III melanomaIn: Annals of Oncology, Vol. 36, 2025, Nr. 10, pp. 1166 – 1177DOI (Open Access)
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Nitro-oleic acid enhances mitochondrial metabolism and ameliorates heart failure with preserved ejection fraction in miceIn: Nature Communications, Vol. 16, 2025, Nr. 1, 3933DOI (Open Access)
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Oxygen evolution reaction on IrO₂(110) is governed by Walden-type mechanismsIn: Nature Communications, Vol. 16, 2025, Nr. 1, 6137DOI (Open Access)
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PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinomaIn: Cell Reports, Vol. 44, 2025, Nr. 4, 115541DOI (Open Access)
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Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasisIn: Nature Cell Biology, 2025, in pressDOI (Open Access)
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Renaissance of Chlorine Evolution Reaction : Emerging Theory and Catalytic MaterialsIn: Angewandte Chemie International Edition, Vol. 64, 2025, Nr. 1, e202417293DOI (Open Access)
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Selective inhibition of mitochondrial Kv1.3 prevents and alleviates multiple sclerosis in vivoIn: EMBO Molecular Medicine, 2025, in pressDOI (Open Access)
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Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II ActivityIn: Cancer Research, Vol. 85, 2025, Nr. 5, pp. 942 – 955DOI (Open Access)
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Small Molecule-Induced Alterations of Protein Polyubiquitination Revealed by Mass-Spectrometric Ubiquitome AnalysisIn: Angewandte Chemie International Edition, Vol. 64, 2025, Nr. 32, e202508916DOI (Open Access)
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Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancerIn: Nature Communications, Vol. 16, 2025, Nr. 1, 335DOI (Open Access)
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Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitorsIn: Nature Communications, Vol. 16, 2025, Nr. 1, 3208DOI (Open Access)
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TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescenceIn: The EMBO Journal, Vol. 44, 2025, Nr. 23, pp. 7119 – 7153DOI, Online Full Text (Open Access)
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Tarlatamab in Small-Cell Lung Cancer after Platinum-Based ChemotherapyIn: The New England Journal of Medicine, Vol. 393, 2025, Nr. 4, pp. 349 – 361
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The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous coronaIn: Science Advances, Vol. 11, 2025, Nr. 37, eady6890DOI (Open Access)
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The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse ModelsIn: Cancer Research, Vol. 85, 2025, Nr. 10, pp. 1769 – 1783
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The Spc105/Kre28 complex promotes mitotic error correction by outer kinetochore recruitment of Ipl1/Sli15In: The EMBO Journal, Vol. 44, 2025, Nr. 12, pp. 3492 – 3520DOI (Open Access)
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The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T cell recognition by targeting CIITAIn: eLife, Vol. 14, 2025, e96414DOI, Online Full Text (Open Access)
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Transcription factor switching drives subtype-specific pancreatic cancerIn: Nature Genetics, 2025, in pressDOI (Open Access)
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Unraveling Relatlimab-Specific Biology Using Biomarker Analyses in Patients with Advanced Melanoma in RELATIVITY-047In: Clinical Cancer Research, Vol. 31, 2025, Nr. 17, pp. 3702 – 3714DOI (Open Access)
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Whole genome and transcriptome profiling in advanced pancreatic cancer patients on the COMPASS trialIn: Nature Communications, Vol. 16, 2025, Nr. 1, 5919DOI (Open Access)
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Young unrelated donors confer a survival advantage for patients with myeloid malignancies compared to older siblingsIn: Leukemia, Vol. 39, 2025, Nr. 10, pp. 2523 – 2532DOI (Open Access)
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[⁶⁸Ga]Ga-FAPI-46 PET accuracy for cancer imaging with histopathology validation : A single-centre, single-arm, interventional, phase 2 trialIn: The Lancet Oncology, Vol. 26, 2025, Nr. 9, pp. 1204 – 1214DOI (Open Access)
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msiFlow : automated workflows for reproducible and scalable multimodal mass spectrometry imaging and microscopy data analysisIn: Nature Communications, Vol. 16, 2025, Nr. 1, 1065DOI (Open Access)