Welcome to ZMB

Welcome to ZMB

The Center of Medical Biotechnology (ZMB) is an interdisciplinary scientific center of the University of Duisburg-Essen, integrating medical research at the University Hospital and natural sciences at the Campus.

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© EKfG

25 Jahre Essener Kolleg für Geschlechterforschung & Kick-off Institut für Geschlechtersensible Medizin

Das Essener Kolleg für Geschlechterforschung (EKfG), eine zentrale wissenschaftliche Einrichtung der Universität Duisburg-Essen und Knotenpunkt des Netzwerks Frauen- und Geschlechterforschung NRW, blickt auf mehr als 25 Jahre erfolgreiche Arbeit in der Geschlechterforschung und Nachwuchsförderung zurück. Das EKfG begeht das Jubiläum gemeinsam mit dem Auftakt des von den langjährigen Sprecherinnen des EKfG-Forschungsclusters "Biomedizinische Forschung und klinische Medizin" Prof. Dr. Anke Hinney und PD Dr. Andrea Kindler-Röhrborn neugegründeten Instituts für Geschlechtersensible Medizin an der Medizinischen Fakultät am 8. März 2024 und lädt dazu herzlich an das Universitätsklinikum Essen ein.

Prgramm
© jannoon028/Freepik

CRC1430 Guest Speaker Series

26.03.2024
Britta Trappmann, DOLCE - Dortmund Life Science Center, TU Dortmund

30.04.2024
Monilola Olayioye, Universität Stuttgart

04.06.2024
Silvia Vega Rubin de Celis, UK Essen

25.06.2024
Yogesh Kulathu, MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee

23.07.2024
Jacques Neefjes, Cell and Chemical Biology, Leiden University Medical Center

All events start at 5.15pm in room S05V01E69.

For further information please contact crc1430@uni-due.de.

© ELH

Erwin L. Hahn Institute: Two Awards offered

[16.01.2024] In 2024, the Erwin L. Hahn Institute for Magnetic Resonance Imaging (ELH) will once again present the International Erwin L. Hahn Institute Award. The ELH honours groundbreaking publications by mid-career scientists in the research areas of the ELH. The prize is awarded for work that combines an innovative approach with scientific excellence, international visibility and a substantial contribution to ultra-high field magnetic resonance imaging. The prize is awarded in the categories BRAIN and BODY, each of which is endowed with EUR 2,500.

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Press Releases 2024/2023

© Ева Поликарпова - stock.adobe.com

Therapie bei Pneumokokken-Meningitis Blockierte Mustererkennungsrezeptoren

[05.03.2024] Meningitis, eine Hirnhautentzündung, kann durch nichtinfektiöse Reize oder eine Infektion mit verschiedenen mikrobiellen Erregern, wie z. B. Pneumokokken (Gram-positive Bakterien) ausgelöst werden. Obwohl wirksame Antibiotika zur Verfügung stehen, können die entzündlichen Prozesse im Hirn zu neurologischen Folgeerscheinungen oder sogar zum Tod führen. Wissenschaftler:innen der Medizinischen Fakultät der Universität Duisburg-Essen (UDE) und des Universitätsklinikums Essen (UK Essen) haben in Kooperation mit Kolleg:innen der Ludwig-Maximilians-Universität (LMU) München und der Universität Greifswald nun untersucht, wie die Antibiotikatherapie bei einer solchen Infektion sinnvoll ergänzt werden kann. Ihre Laborversuche zeigen, dass die Blockade der Rezeptoren TLR2 und TLR13 dabei helfen kann, die schädlichen Entzündungsprozesse auszubremsen.

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© UDE/Frank Preuß

Onkologie und Wirkstoffforschung Gemeinsame Erfolge bei seltenem Magen-Darm-Krebs

[29.02.2024] Wie lassen sich gastrointestinale Stromatumoren (kurz: GIST) behandeln und neue Therapien entwickeln? Diesen Fragen gehen die Arbeitsgruppen von Prof. Dr. Daniel Rauh (TU Dortmund) und Prof. Dr. Sebastian Bauer (Westdeutsches Tumorzentrum, UK Essen sowie Medizinische Fakultät UDE) gemeinsam nach. Seit mehr als zehn Jahren kämpfen die Essener Onkologie und die Dortmunder Wirkstoffforschung gegen den seltenen Magen/Darm-Krebs GIST. Aktuelle Ergebnisse ihrer Zusammenarbeit wurden jetzt im Journal of Clinical Oncology und in Nature Communications veröffentlicht.

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© TU DO, RUB, UDE

University Alliance Ruhr Important step towards excellence

[02.02.2024] With combined strength, the University Alliance Ruhr (UA Ruhr) has reached the second round of the Excellence Strategy competition: scientists from Ruhr-Universität Bochum, TU Dortmund University and the University of Duisburg-Essen are involved in a total of four research projects that can now submit a full application as a Cluster of Excellence. This promising interim result emphasises the potential of the cooperation between the three universities in the Ruhr region in order to jointly apply as a Cluster of Excellence in the coming year.

The research programme "REASONS - River Ecosystems in the Anthroposcene - sustainable scientific SOlutioNS", in which the University of Duisburg-Essen wants to develop a new, sustainable concept for the management of water bodies with the participation of scientists from Ruhr-Universität Bochum and other partners, was able to impress in the current selection round.

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© Perihan Nalbant

Neue Erkenntnisse zu Signalproteinen Wie sich Zellen bewegen

[01.02.2024] Den Forschungsgruppen um Prof. Dr. Perihan Nalbant (Zentrum für Medizinische Biotechnologie der UDE) und Dr. Leif Dehmelt (Chemie und Chemische Biologie, TU Dortmund) ist es gelungen, die Signale sichtbar zu machen, welche die Formänderungen in der Zellmigration steuern. Ihre Ergebnisse könnten helfen, die Metastasierung von Krebs besser zu verstehen. Die renommierten Fachjournale Nature Communications und Molecular Biology of the Cell haben berichtet.

Die Migration von Zellen ist entscheidend für viele Prozesse im Körper. Auch bei einer Immunantwort „migrieren Zellen in komplexen Geweben“, wie es fachsprachlich heißt. Sind die Mechanismen gestört, kann es zu einer unkontrollierten Zellwanderung kommen – beispielsweise, wenn Krebs streut.

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© UDE

Schwimmverhalten von Spermien Weichmacher verändern vorübergehend Beweglichkeit

[24.01.2024] Ungewollte Kinderlosigkeit betrifft in Deutschland zirka ein Drittel aller Paare zwischen 25 und 50 Jahren. Bei wiederum etwa einem Drittel sind die Ursachen dafür nicht geklärt. Insbesondere bei männlichen Fruchtbarkeitsstörungen stehen immer wieder sogenannte Weichmacher im Fokus, die in vielen Alltagsgegenständen wie Plastikflaschen, Trinkbecherbeschichtungen oder sogar Kassenbons enthalten sind. Die Arbeitsgruppe um Prof. Dr. Gunther Wennemuth von der Medizinischen Fakultät der UDE ging daher der Frage nach, wie sich Weichmacher auf Spermien auswirken. Sie konnte zeigen, dass diese vorübergehend die Beweglichkeit der Spermien verringern. Ihre Ergebnisse haben die Forschenden kürzlich in der Fachzeitschrift Exposure and Health veröffentlicht.

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© UME

Exzellenzförderung für Essener Krebsexperten Neue Behandlungsperspektiven für Tumoren des Immunsystems

[23.01.2024] Die Deutsche Krebshilfe unterstützt Forschende der Medizinischen Fakultät der Universität Duisburg-Essen im Zuge ihres DKH-Exzellenzförderprogramms für etablierte Forschende bis 2028 mit rund einer Million Euro. Gefördert wird ein Projekt von Prof. Dr. Christian Reinhardt, Direktor der Klinik für Hämatologie und Stammzelltransplantation am Universitätsklinikum Essen. Seine Forschung zielt darauf ab, die Heilungschancen von Patient:innen zu verbessern, bei denen das diffuse großzellige B-Zell-Lymphom zu schweren Krankheitsversläufen führt. Die durch Krebs ausgelöste Vergrößerung der Lymphknoten ist die häufigste Lymphom-Erkrankung bei Erwachsenen.

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© UDE/Matthias Gunzer

Neues Mikroskop für Analyse von Immunzellen Sichtbar mehr Bewegung

[11.12.2023] Immunzellen bekämpfen Krankheitserreger oder entartete Zellen in der Krebsentstehung in unserem Körper und bewegen sich dafür durch Blut und Gewebe. Am falschen Ort jedoch können sie Schaden anrichten. Daher ist es sinnvoll, dieses Migrationsverhalten zu untersuchen und wenn nötig zu unterdrücken. Die bisherige Videomikroskopie erlaubt jedoch nur eine langsame Bewegungsanalyse einzelner Zellproben. Forschende der Universität Duisburg-Essen und des Leibniz-Instituts für Analytische Wissenschaften haben nun ein Mikroskop entwickelt, das 64 – künftig sogar 384 – Proben in kurzer Zeit beobachtet. Über ComplexEye (dt. etwa Facettenauge oder Komplexauge) berichtet nun Nature Communications.

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© fotogestoeber - stock.adobe.com

Neue MERCUR-Förderungen Projekte zum Brückenbauen

[07.12.2023] Das Mercator Research Center Ruhr (MERCUR) bewilligt in seiner aktuellen Ausschreibungsrunde über 840.000 Euro für kooperative Forschungsprojekte innerhalb der Universitätsallianz Ruhr (UA Ruhr): Die UDE ist an allen Projekten beteiligt.
"Synthetic Nucleic Acid Systems" schlägt eine Brücke zwischen den Forschungsaktivitäten der Chemischen Biologie, Zellbiologie sowie DNA-Nanotechnologie an der UDE und der TU Dortmund. Das Team will so eine experimentelle und wissensbasierte Grundlage schaffen, um gemeinsam funktionale Nukleinsäuresysteme zu erforschen und neu zu gestalten. Nukleinsäuren spielen als genetischer Informationsträger, regulatorische Elemente, Bindungsplattformen und Katalysatoren in allen biologischen Systemen eine entscheidende Rolle.

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© UDE/AG Tumormetabolismus

1,5 Mio. Euro für Hautkrebsforschung ERC Starting Grant für Alpaslan Tasdogan

[07.12.2023] Europas führende Förderorganisation, der Europäische Forschungsrat (ERC), unterstützt die Hautkrebsforschung von Wissenschaftler:innen der Medizinischen Fakultät der UDE bis 2028 mit 1,5 Millionen Euro. Mit einem „ERC Starting Grant“ fördert das EU-Gremium den Onkologen und Dermatologen Prof. Dr. Dr. Alpaslan Tasdogan. Erstmals geht diese Förderung an einen in Essen tätigen Forscher. Ziel von Professor Tasdogan und seinem Team ist, durch Untersuchungen an Patient:innen besser zu verstehen, warum sich gesunde Zellen in Zellen des Schwarzen Hautkrebses verwandeln, im Körper streuen und wie diese Metastasen bekämpft werden können.

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Research Magazine UDE
Focus: Health

Good Killer Cells

Chemotherapy, radiotherapy or surgery – these are the three common forms of cancer therapy. The lymphoma specialists at University Hospital Essen are investigating the possibility of a different approach.

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Research Magazine UDE
Focus: Health

Please treat unequally

Height: just under 1.80 meters; weight: approximately 85 kilograms. One X and one Y chromosome. This has been more or less accepted as the norm in medical research – until now. Prof. Dr Anke Hinney is about to change that.

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Research Magazine UDE
Focus: Health

One Health

What happens deep down in Earth’s subsurface? That’s the focus of Alexander Probst’s research. He also studies how microorganisms influence environmental health. The research professor at the new Research Center One Health Ruhr has declared war on antibiotic resistances.

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ZMB Research Programs

Oncology

The concept of this research program is to understand fundamental processes in tumor biology in order to develop novel molecularly defined and rationally applied cancer treatments.

Participating researchers from biology, experimental and clinical medicine study tumors as “biological systems" and so called “neo-organs”.

A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumor development, growth, progression and tumor cell migration.

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Immunology, Infectious Diseases and Transplantation

The immune system responds to various pathogens including viruses and bacteria in different ways to prevent severe disease and persistence in the host. Many pathogens, however, have developed mechanisms to evade immune defence.

The molecular and cellular interactions of pathogens with the immune system are studied within this program.

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Molecular and Chemical Cell Biology

Molecular and chemical cell biology is an interdisciplinary research program connecting molecular cell biology and genetics with chemistry and structural biology. Scientists of the participating disciplines collaborate to advance the understanding of basic molecular mechanisms of important biological processes.

The analysis of regulation and deregulation of key pathways is linking basic biology with pathophysiology.

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Latest Publications

    Journal articles

  • Pozniak, Joanna; Pedri, Dennis; Landeloos, Ewout; Van Herck, Yannick; Antoranz, Asier; Vanwynsberghe, Lukas; Nowosad, Ada; Roda, Niccolò; Makhzami, Samira; Bervoets, Greet; Maciel, Lucas Ferreira; Pulido-Vicuña, Carlos Ariel; Pollaris, Lotte; Seurinck, Ruth; Zhao, Fang; Flem-Karlsen, Karine; Damsky, William; Chen, Limin; Karagianni, Despoina; Cinque, Sonia; Kint, Sam; Vandereyken, Katy; Rombaut, Benjamin; Voet, Thierry; Vernaillen, Frank; Annaert, Wim; Lambrechts, Diether; Boecxstaens, Veerle; Saeys, Yvan; van den Oord, Joost; Bosisio, Francesca; Karras, Panagiotis; Shain, A. Hunter; Bosenberg, Marcus; Leucci, Eleonora; Paschen, Annette; Rambow, Florian; Bechter, Oliver; Marine, Jean-Christophe
    A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma
    In: Cell Vol. 187 (2024) Nr. 1, pp. 166 - 183.e25
  • Teuber, A.; Schulz, T.; Fletcher, B.S.; Gontla, R.; Mühlenberg, Thomas; Zischinsky, M.-L.; Niggenaber, J.; Weisner, J.; Kleinbölting, S.B.; Lategahn, J.; Sievers, S.; Müller, M.P.; Bauer, Sebastian; Rauh, D.
    Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA
    In: Nature Communications Vol. 15 (2024) Nr. 1, 63
  • Heinrich, Michael C.; Jones, Robin L.; George, Suzanne; Gelderblom, Hans; Schöffski, Patrick; von Mehren, Margaret; Zalcberg, John R.; Kang, Yoon-Koo; Razak, Albiruni Abdul; Trent, Jonathan; Attia, Steven; Le Cesne, Axel; Siontis, Brittany L.; Goldstein, David; Boye, Kjetil; Sanchez, Cesar; Steeghs, Neeltje; Rutkowski, Piotr; Druta, Mihaela; Serrano, César; Somaiah, Neeta; Chi, Ping; Reichmann, William; Sprott, Kam; Achour, Haroun; Sherman, Matthew L.; Ruiz-Soto, Rodrigo; Blay, Jean-Yves; Bauer, Sebastian
    Ripretinib versus sunitinib in gastrointestinal stromal tumor : ctDNA biomarker analysis of the phase 3 INTRIGUE trial
    In: Nature Medicine (2024) in press
  • Polley, Soumitra; Raisch, Tobias; Ghetti, Sabrina; Körner, Marie; Terbeck, Melina; Gräter, Frauke; Raunser, Stefan; Aponte-Santamaría, Camilo; Vetter, Ingrid R.; Musacchio, Andrea
    Structure of the human KMN complex and implications for regulation of its assembly
    In: Nature Structural & Molecular Biology (2024) in press
  • Musacchio, Andrea
    Thirty years of structural changes
    In: Nature Structural & Molecular Biology (2024) in press
  • Day, Matthew; Tetik, Bilal; Parlak, Milena; Almeida-Hernández, Yasser; Räschle, Markus; Kaschani, Farnusch; Siegert, Heike; Marko, Anika; Sanchez-Garcia, Elsa; Kaiser, Markus; Barker, Isabel A.; Pearl, Laurence H.; Oliver, Antony W.; Boos, Dominik
    TopBP1 utilises a bipartite GINS binding mode to support genome replication
    In: Nature Communications Vol. 15 (2024) Nr. 1, 1797
  • Knittel, Gero; Reinhardt, Hans Christian
    XPO1-Mediated mRNA Export of Genome Maintenance Regulators Drives Chemotherapy Resistance in Aggressive Lymphoma
    In: Cancer Research Vol. 84 (2024) Nr. 1, pp. 3 - 5
  • Kebir, Sied; Ullrich, Vivien; Berger, Pia; Dobersalske, Celia; Langer, Sarah; Rauschenbach, Laurèl; Trageser, Daniel; Till, Andreas; Lorbeer, Franziska K.; Wieland, Anja; Wilhelm-Buchstab, Timo; Ahmad, Ashar; Fröhlich, Holger; Cima, Igor; Prasad, Shruthi; Matschke, Johann; Jendrossek, Verena; Remke, Marc; Grüner, Barbara M.; Rösch, Alexander; Siveke, Jens; Herold-Mende, Christel; Blau, Tobias; Keyvani, Kathy; van Landeghem, Frank K H; Pietsch, Torsten; Felsberg, Jörg; Reifenberger, Guido; Weller, Michael; Sure, Ulrich; Brüstle, Oliver; Simon, Matthias; Glas, Martin; Scheffler, Björn
    A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma
    In: Clinical Cancer Research Vol. 29 (2023) Nr. 2, pp. 488 - 500
  • Karreman, Matthia A.; Bauer, Alexander T.; Solecki, Gergely; Berghoff, Anna S.; Mayer, Chanté D; Frey, Katharina; Hebach, Nils; Feinauer, Manuel J.; Schieber, Nicole L.; Tehranian, Cedric; Mercier, Luc; Singhal, Mahak; Venkataramani, Varun; Schubert, Marc C.; Hinze, Daniel; Hölzel, Michael; Helfrich, Iris; Schadendorf, Dirk; Schneider, Stefan W.; Westphal, Dana; Augustin, Hellmut G.; Goetz, Jacky G.; Schwab, Yannick; Wick, Wolfgang; Winkler, Frank
    Active Remodeling of Capillary Endothelium via Cancer Cell-Derived MMP9 Promotes Metastatic Brain Colonization
    In: Cancer Research Vol. 83 (2023) Nr. 8, pp. 1299 - 1314
  • Becker, Jürgen; Ugurel, Selma; Leiter, Ulrike; Meier, Friedegund; Gutzmer, Ralf; Haferkamp, Sebastian; Zimmer, Lisa; Livingstone, Elisabeth; Eigentler, Thomas K; Hauschild, Axel; Kiecker, Felix; Hassel, Jessica C; Mohr, Peter; Fluck, Michael; Thomas, Ioannis; Garzarolli, Marlene; Grimmelmann, Imke; Drexler, Konstantin; Spillner, Alexandra N; Eckhardt, Sebastian; Schadendorf, Dirk; van Akkoi, Alexander; van Houdt, Winan; Wilhelm, Tabea; Farmer, Kimberly; Ulrich, Claas; Gambichler, Thilo; Bluhm, Leonie; Schinagl, Heidemarie; Kellner, Ivonne; Herbst, Rudolf; Meiß, Frank; Rafei-Shamsabadi, David; Sell, Sabine; Kaatz, Martin; Wulfken, Lena; Hartmann, Martin; Kähler, Katharina; Ziemer, Mirjana; Simon, Jan; Terheyden, Patrick; Thaci, Diamant; Loquai, Carmen; Mitzel-Rink, Heidrun; Grabbe, Stephan; Stege, Henner; Gaiser, Maria; Utikal, Jochen; Berking, Carola; Heinzerling, Lucie; Schlaak, Max; Tomsitz, Dirk; Dyballa, Jörg; Magnolo, Nina; Weishaupt, Carsten; Berneburg, Mark; Garbe, Claus; Flatz, Lukas; Gesierich, Anja; Schilling, Bastian
    Adjuvant immunotherapy with nivolumab versus observation in completely resected Merkel cell carcinoma (ADMEC-O) : disease-free survival results from a randomised, open-label, phase 2 trial
    In: Lancet Vol. 402 (2023) Nr. 10404, pp. 798 - 808
  • Berning, Philipp; Schmitz, Norbert; Ngoya, Maud; Finel, Hervé; Boumendil, Ariane; Wang, Fengrong; Huang, Xiao-Jun; Hermine, Olivier; Philippe, Laure; Couronné, Lucile; Jaccard, Arnaud; Liu, Daihong; Wu, Depei; Reinhardt, Christian; Chalandon, Yves; Wagner-Drouet, Eva; Kwon, Mi; Zhang, Xi; Carpenter, Ben; Yakoub-Agha, Ibrahim; Wulf, Gerald; López-Jiménez, Javier; Sanz, Jaime; Labussière-Wallet, Hélène; Shimoni, Avichai; Dreger, Peter; Sureda, Anna; Kim, Won Seog; Glass, Bertram
    Allogeneic hematopoietic stem cell transplantation for NK/T-cell lymphoma : An international collaborative analysis
    In: Leukemia Vol. 37 (2023) Nr. 7, pp. 1511 - 1520
  • Cortés-Ciriano, Isidro; Küppers, Ralf; Schadendorf, Dirk; Park, Peter J.
    Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
    In: Nature Genetics Vol. 55 (2023) Nr. 6, 1076
  • Yuan, Yuan; Küppers, Ralf; Schadendorf, Dirk; Park, Keunchil; Campbell, Peter J.; Liang, Han
    Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers
    In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1078
  • Akdemir, Kadir C.; Küppers, Ralf; Schadendorf, Dirk; Futreal, P. Andrew
    Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
    In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1079
  • Catton, Erin A.; Bonsor, Daniel A.; Herrera, Carolina; Stålhammar-Carlemalm, Margaretha; Lyndin, Mykola; Turner, Claire E.; Soden, Jo; van Strijp, Jos A G; Singer, Bernhard B.; van Sorge, Nina M.; Lindahl, Gunnar; McCarthy, Alex J.
    Author Correction: Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis
    In: Nature Communications Vol. 14 (2023) Nr. 1, pp. 2675
  • Küppers, Ralf; Schadendorf, Dirk; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, et.al.
    Author Correction: Pan-cancer analysis of whole genomes
    In: Nature Vol. 614 (2023) Nr. 7948, pp. E39
  • Rodriguez-Martin, Bernardo; Schadendorf, Dirk; Campbell, Peter J.
    Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
    In: Nature Genetics Vol. 55 (2023) Nr. 6, 1080
  • Zapatka, Marc; Schadendorf, Dirk; Lichter, Peter
    Author Correction: The landscape of viral associations in human cancers
    In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1077
  • Eertink, J.J.; Zwezerijnen, G.J.C.; Heymans, M.W.; Pieplenbosch, S.; Wiegers, S.E.; Dührsen, U.; Hüttmann, Andreas; Kurch, L.; Hanoun, C.; Lugtenburg, P.J.; Barrington, S.F.; Mikhaeel, N.G.; Ceriani, L.; Zucca, E.; Czibor, S.; Györke, T.; Chamuleau, M.E.D.; Hoekstra, O.S.; de Vet, H.C.W.; Boellaard, R.; Zijlstra, J.M.; Eertink, Jakoba Johanna; Zwezerijnen, Gerben JC; Heymans, Martijn; Wiegers, Sanne Elisabeth; Lugtenburg, Pieternella J.; Barrington, Sally; Mikhaeel, N. George; Chamuleau, Martine E.D.; Hoekstra, Otto S; De Vet, Henrica CW; Zijlstra, Josée M.
    Baseline PET radiomics outperforms the IPI risk score for prediction of outcome in diffuse large B-cell lymphoma
    In: Blood Vol. 141 (2023) Nr. 25, pp. 3055 - 3064
  • Cao, Yunjun; Mieres-Perez, Joel; Rowen, Julien Frederic; Sanchez-Garcia, Elsa; Sander, Wolfram; Morgenstern, Karina
    Chirality control of a single carbene molecule by tip-induced van der Waals interactions
    In: Nature Communications Vol. 14 (2023) Nr. 1, 4500
  • Serrano, C.; Bauer, Sebastian; Gómez-Peregrina, D.; Kang, Y.-K.; Jones, R.L.; Rutkowski, P.; Mir, O.; Heinrich, M.C.; Tap, W.D.; Newberry, K.; Grassian, A.; Shi, H.; Bialick, S.; Schöffski, P.; Pantaleo, M.A.; von Mehren, M.; Trent, J.C.; George, S.
    Circulating tumor DNA analysis of the phase III VOYAGER trial : KIT mutational landscape and outcomes in patients with advanced gastrointestinal stromal tumor treated with avapritinib or regorafenib
    In: Annals of Oncology Vol. 34 (2023) Nr. 7, pp. 615 - 625
  • Hoi, David M.; Junker, Sabryna; Junk, Lukas; Schwechel, Kristin; Fischel, Katharina; Podlesainski, David; Hawkins, Paige M.E.; van Geelen, Lasse; Kaschani, Farnusch; Leodolter, Julia; Morreale, Francesca Ester; Kleine, Stefan; Guha, Somraj; Rumpel, Klaus; Schmiedel, Volker M.; Weinstabl, Harald; Meinhart, Anton; Payne, Richard J.; Kaiser, Markus; Hartl, Markus; Boehmelt, Guido; Kazmaier, Uli; Kalscheuer, Rainer; Clausen, Tim
    Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival
    In: Cell Vol. 186 (2023) Nr. 10, pp. 2176 - 2192.e22
  • Cameron, Donald P.; Grosser, Jan; Ladigan, Swetlana; Kuzin, Vladislav; Iliopoulou, Evanthia; Wiegard, Anika; Benredjem, Hajar; Jackson, Kathryn; Liffers, Sven T.; Lueong, Smiths; Cheung, Phyllis F.; Vangala, Deepak; Pohl, Michael; Viebahn, Richard; Teschendorf, Christian; Wolters, Heiner; Usta, Selami; Geng, Keyi; Kutter, Claudia; Arsenian-Henriksson, Marie; Siveke, Jens; Tannapfel, Andrea; Schmiegel, Wolff; Hahn, Stephan A.; Baranello, Laura
    Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription
    In: Science Advances Vol. 9 (2023) Nr. 41, eadg5109
  • Cibir, Zülal; Hassel, Jacqueline; Sonneck, Justin; Kowitz, Lennart; Beer, Alexander; Kraus, Andreas; Hallekamp, Gabriel; Rosenkranz, Martin; Raffelberg, Pascal; Olfen, Sven; Smilowski, Kamil; Burkard, Roman; Helfrich, Iris; Tuz, Ali Ata; Singh, Vikramjeet; Ghosh, Susmita; Sickmann, Albert; Klebl, Anne-Kathrin; Eickhoff, Jan Eike; Klebl, Bert; Seidl, Karsten; Chen, Jianxu; Grabmaier, Anton; Viga, Reinhard; Gunzer, Matthias
    ComplexEye : a multi-lens array microscope for high-throughput embedded immune cell migration analysis
    In: Nature Communications Vol. 14 (2023) Nr. 1, 8103
  • Cortés-Ciriano, Isidro; Küppers, Ralf; Schadendorf, Dirk; Park, Peter J.
    Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
    In: Nature Genetics Vol. 52 (2023) pp. 331 - 341
  • Yuan, Yuan; Küppers, Ralf; Schadendorf, Dirk; Park, Keunchil; Campbell, Peter J.; Liang, Han
    Comprehensive molecular characterization of mitochondrial genomes in human cancers
    In: Nature Genetics Vol. 52 (2023) pp. 342 - 352
  • Alaggio, Rita; Amador, Catalina; Anagnostopoulos, Ioannis; Xiao, Wenbin; et al.; Küppers, Ralf; the International Agency for Research on Cancer / World Health Organization
    Correction: “The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms” Leukemia. 2022 Jul;36(7):1720–1748
    In: Leukemia Vol. 37 (2023) Nr. 9, pp. 1944 - 1951
  • Bayraktar, Evren; Graf, Theresa; Ayuk, Francis A.; Beutel, Gernot; Penack, Olaf; Luft, Thomas; Brueder, Nicole; Castellani, Gastone; Reinhardt, H. Christian; Kröger, Nicolaus; Beelen, Dietrich W.; Turki, Amin T.
    Data-driven grading of acute graft-versus-host disease
    In: Nature Communications Vol. 14 (2023) Nr. 1, 7799
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