ZMB Member Christian Reinhardt

ZMB Member
Christian Reinhardt

Next ZMB-Member
Christian Reinhardt portrait
© UDE/Frank Preuß

Prof. Dr. Christian Reinhardt

Director of:

Clinic for Hematology and Stem Cell Transplantation

West German Cancer Centre (WTZ)
University Hospital Essen
Hufelandstraße 55
45147 Essen

Research Overview

  • B cell lymphomas
  • Lung Cancer
  • Functional Genomics
  • DNA Damage
  • Transcription factor p53

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Selected Publications

    Journal articles

  • Kohlhaas, Vivien; Blakemore, Stuart James; Al-Maarri, Mona; Nickel, Nadine; Pal, Martin; Roth, Andreas; Hövelmeyer, Nadine; Schäfer, Stephan C.; Knittel, Gero; Lohneis, Philipp; Nikolic, Milos; Wiederstein, Janica L.; Franitza, Marek; Georgomonolis, Theodoros; Reinart, Nina; Herling, Marco; Herling, Carmen; Hartmann, Elena M.; Rosenwald, Andreas; Klapper, Wolfram; Büttner, Reinhard; Moia, Riccardo; Rossi, Davide; Boldorini, Renzo; Gaidano, Gianluca; Frenzel, Lukas P.; Reinhardt, Christian; Brüning, Jens C.; Hallek, Michael; Krüger, Marcus; Peifer, Martin; Pallasch, Christian P.; Wunderlich, F. Thomas
    Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1
    In: Blood Vol. 137 (2021) Nr. 5, pp. 646 - 660
    ISSN: 1528-0020; 0006-4971
    Online Full Text: dx.doi.org/
  • Gremke, Niklas; Polo, Pierfrancesco; Dort, Aaron; Schneikert, Jean; Elmshäuser, Sabrina; Brehm, Corinna; Klingmüller, Ursula; Schmitt, Anna; Reinhardt, Hans Christian; Timofeev, Oleg; Wanzel, Michael; Stiewe, Thorsten
    mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4684
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Jachimowicz, Ron D.; Beleggia, Filippo; Isensee, Jörg; Velpula, Bhagya Bhavana; Goergens, Jonas; Bustos, Matias A.; Doll, Markus A.; Shenoy, Anjana; Checa-Rodriguez, Cintia; Wiederstein, Janica Lea; Baranes-Bachar, Keren; Bartenhagen, Christoph; Hertwig, Falk; Teper, Nizan; Nishi, Tomohiko; Schmitt, Anna; Distelmaier, Felix; Lüdecke, Hermann-Josef; Albrecht, Beate; Krüger, Marcus; Schumacher, Björn; Geiger, Tamar; Hoon, Dave S.B.; Huertas, Pablo; Fischer, Matthias; Hucho, Tim; Peifer, Martin; Ziv, Yael; Reinhardt, H. Christian; Wieczorek, Dagmar; Shiloh, Yosef
    UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors
    In: Cell Vol. 176 (2019) Nr. 3, pp. 505 - 519.e22
    ISSN: 0092-8674; 1097-4172
    Online Full Text: dx.doi.org/ (Open Access)
  • Knittel, Gero; Rehkämper, Tim; Korovkina, Darya; Liedgens, Paul; Fritz, Christian; Torgovnick, Alessandro; Al-Baldawi, Yussor; Al-Maarri, Mona; Cun, Yupeng; Fedorchenko, Oleg; Riabinska, Arina; Beleggia, Filippo; Nguyen, Phuong-Hien; Wunderlich, F. Thomas; Ortmann, Monika; Montesinos-Rongen, Manuel; Tausch, Eugen; Stilgenbauer, Stephan; Frenzel, Lukas P.; Herling, Marco; Herling, Carmen; Bahlo, Jasmin; Hallek, Michael; Peifer, Martin; Buettner, Reinhard; Persigehl, Thorsten; Reinhardt, Christian
    Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia
    In: Nature Communications Vol. 8 (2017) Nr. 1, pp. 153
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Knittel, Gero; Liedgens, Paul; Korovkina, Darya; Seeger, Jens M.; Al-Baldawi, Yussor; Al-Maarri, Mona; Fritz, Christian; Vlantis, Katerina; Bezhanova, Svetlana; Scheel, Andreas H.; Wolz, Olaf-Oliver; Reimann, Maurice; Möller, Peter; López, Cristina; Schlesner, Matthias; Lohneis, Philipp; Weber, Alexander N. R.; Trümper, Lorenz; Staudt, Louis M.; Ortmann, Monika; Pasparakis, Manolis; Siebert, Reiner; Schmitt, Clemens A.; Klatt, Andreas R.; Wunderlich, F. Thomas; Schäfer, Stephan C.; Persigehl, Thorsten; Montesinos-Rongen, Manuel; Odenthal, Margarete; Büttner, Reinhard; Frenzel, Lukas P.; Kashkar, Hamid; Reinhardt, Christian
    B-cell-specific conditional expression of Myd88p.L²⁵²P leads to the development of diffuse large B-cell lymphoma in mice
    In: Blood Vol. 127 (2016) Nr. 22, pp. 2732 - 2741
    ISSN: 1528-0020; 0006-4971
    Online Full Text: dx.doi.org/ (Open Access)
  • Dietlein, Felix; Kalb, Bastian; Jokic, Mladen; Noll, Elisa M.; Strong, Alexander; Tharun, Lars; Ozretić, Luka; Künstlinger, Helen; Kambartel, Kato; Randerath, Winfried J.; Jüngst, Christian; Schmitt, Anna; Torgovnick, Alessandro; Richters, André; Rauh, Daniel; Siedek, Florian; Persigehl, Thorsten; Mauch, Cornelia; Bartkova, Jirina; Bradley, Allan; Sprick, Martin R.; Trumpp, Andreas; Rad, Roland; Saur, Dieter; Bartek, Jiri; Wolf, Jürgen; Büttner, Reinhard; Thomas, Roman K.; Reinhardt, Christian
    A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer
    In: Cell Vol. 162 (2015) Nr. 1, pp. 146 - 159
    ISSN: 1097-4172; 0092-8674
    Online Full Text: dx.doi.org/ (Open Access)
  • George, Julie; Lim, Jing Shan; Jang, Se Jin; Cun, Yupeng; Ozretia, Luka; Kong, Gu; Leenders, Frauke; Lu, Xin; Fernández-Cuesta, Lynnette; Bosco, Graziella; Müller, Christian; Dahmen, Ilona; Jahchan, Nadine S.; Park, Kwon-Sik; Yang, Dian; Karnezis, Anthony N.; Vaka, Dedeepya; Torres, Angela; Wang, Maia Segura; Korbel, Jan O.; Menon, Roopika; Chun, Sung-Min; Kim, Deokhoon; Wilkerson, Matt; Hayes, Neil; Engelmann, David; Pützer, Brigitte; Bos, Marc; Michels, Sebastian; Vlasic, Ignacija; Seidel, Danila; Pinther, Berit; Schaub, Philipp; Becker, Christian; Altmüller, Janine; Yokota, Jun; Kohno, Takashi; Iwakawa, Reika; Tsuta, Koji; Noguchi, Masayuki; Muley, Thomas; Hoffmann, Hans; Schnabel, Philipp A.; Petersen, Iver; Chen, Yuan; Soltermann, Alex; Tischler, Verena; Choi, Chang-Min; Kim, Yong-Hee; Massion, Pierre P.; Zou, Yong; Jovanovic, Dragana; Kontic, Milica; Wright, Gavin M.; Russell, Prudence A.; Solomon, Benjamin; Koch, Ina; Lindner, Michael; Muscarella, Lucia A.; La Torre, Annamaria; Field, John K.; Jakopovic, Marko; Knezevic, Jelena; Castaños-Vélez, Esmeralda; Roz, Luca; Pastorino, Ugo; Brustugun, Odd-Terje; Lund-Iversen, Marius; Thunnissen, Erik; Köhler, Jens; Schuler, Martin; Botling, Johan; Sandelin, Martin; Sanchez-Cespedes, Montserrat; Salvesen, Helga B.; Achter, Viktor; Lang, Ulrich; Bogus, Magdalena; Schneider, Peter M.; Zander, Thomas; Ansén, Sascha; Hallek, Michael; Wolf, Jürgen; Vingron, Martin; Yatabe, Yasushi; Travis, William D.; Nürnberg, Peter; Reinhardt, Christian; Perner, Sven; Heukamp, Lukas; Büttner, Reinhard; Haas, Stefan A.; Brambilla, Elisabeth; Peifer, Martin; Sage, Julien; Thomas, Roman K.
    Comprehensive genomic profiles of small cell lung cancer
    In: Nature Vol. 524 (2015) Nr. 7563, pp. 47 - 53
    ISSN: 1476-4687; 0028-0836
    Online Full Text: dx.doi.org/ (Open Access)
  • Dietlein, Felix; Kalb, Bastian; Jokic, Mladen; Noll, Elisa M.; Strong, Alexander; Tharun, Lars; Ozretić, Luka; Künstlinger, Helen; Kambartel, Kato; Randerath, Winfried J.; Jüngst, Christian; Schmitt, Anna; Torgovnick, Alessandro; Richters, André; Rauh, Daniel; Siedek, Florian; Persigehl, Thorsten; Mauch, Cornelia; Bartkova, Jirina; Bradley, Allan; Sprick, Martin R.; Trumpp, Andreas; Rad, Roland; Saur, Dieter; Bartek, Jiri; Wolf, Jürgen; Büttner, Reinhard; Thomas, Roman K.; Reinhardt, Christian
    Erratum: A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer
    In: Cell Vol. 162 (2015) Nr. 5, pp. 1169
    ISSN: 1097-4172; 0092-8674
    Online Full Text: dx.doi.org/ (Open Access)
  • Dietlein, Felix; Thelen, Lisa; Jokic, Mladen; Jachimowicz, Ron D.; Ivan, Laura; Knittel, Gero; Leeser, Uschi; van Oers, Johanna; Edelmann, Winfried; Heukamp, Lukas C.; Reinhardt, Christian
    A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDC
    In: Cancer Discovery Vol. 4 (2014) Nr. 5, pp. 592 - 605
    ISSN: 2159-8290; 2159-8274
    Online Full Text: dx.doi.org/ (Open Access)
  • Janes, Kevin A.; Reinhardt, Christian; Yaffe, Michael B.
    Cytokine-Induced Signaling Networks Prioritize Dynamic Range over Signal Strength
    In: Cell Vol. 135 (2008) Nr. 2, pp. 343 - 354
    ISSN: 0092-8674; 1097-4172
    Online Full Text: dx.doi.org/ (Open Access)
  • Wilker, Erik W.; van Vugt, Marcel A. T. M.; Artim, Steven A.; Huang, Paul H.; Petersen, Christian P.; Reinhardt, Christian; Feng, Yun; Sharp, Phillip A.; Sonenberg, Nahum; White, Forest M.; Yaffe, Michael B.
    14-3-3σ controls mitotic translation to facilitate cytokinesis
    In: Nature Vol. 446 (2007) Nr. 7133, pp. 329 - 332
    ISSN: 1476-4687; 0028-0836
    Online Full Text: dx.doi.org/
  • Reinhardt, Christian; Aslanian, Aaron S.; Lees, Jacqueline A.; Yaffe, Michael B.
    p53-Deficient Cells Rely on ATM- and ATR-Mediated Checkpoint Signaling through the p38MAPK/MK2 Pathway for Survival after DNA Damage
    In: Cancer Cell Vol. 11 (2007) Nr. 2, pp. 175 - 189
    ISSN: 1535-6108; 1878-3686
    Online Full Text: dx.doi.org/ (Open Access)
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