ZMB Member Christian Reinhardt

ZMB Member
Christian Reinhardt

Next ZMB-Member
Christian Reinhardt portrait
© UDE/Frank Preuß

Prof. Dr. Christian Reinhardt

Director of:

Clinic for Hematology and Stem Cell Transplantation

West German Cancer Centre (WTZ)
University Hospital Essen
Hufelandstraße 55
45147 Essen

Research Overview

  • B cell lymphomas
  • Lung Cancer
  • Functional Genomics
  • DNA Damage
  • Transcription factor p53

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Selected Publications

    Journal articles

  • Stahl, David; Gödel, Philipp; Balke-Want, Hyatt; Gholamipoorfard, Rahil; Segbers, Paul; Tetenborg, Luis; Koker, Mirjam; Dörr, Janina; Gregor, Lisa; Bachurski, Daniel; Rose, France; Simon, Adrian G.; Good, Zinaida; Jakob, Josefine; Häupl, Björn; Nill, Marieke; Flümann, Ruth; Riet, Tobias; Lange, Dinah; Blakemore, Stuart J.; Baurmann, Herrad; Voltin, Conrad-Amadeus; Potter, Nicole; Schlözer, Lilli; Freihammer, Max; Wagener-Ryczek, Svenja; Iuga, Andra-Iza; Heger, Jan-Michel; Ludwig, Hanna; Schleifenbaum, Julia K.; Propp, Jessica; Bröckelmann, Paul J.; Jachimowicz, Ron D.; Knittel, Gero; Borchmann, Sven; Merkelbach-Bruse, Sabine; Pallasch, Christian; Peifer, Martin; Rybniker, Jan; Quaas, Alexander; Nitz, Mark; Brägelmann, Johannes; Müller, Werner; Persigehl, Thorsten; Bozek, Katarzyna; Theobald, Sebastian J.; Büttner, Reinhard; Oellerich, Thomas; Hallek, Michael; Kobold, Sebastian; Chmielewski, Markus; Reinhardt, Christian; Mackall, Crystal; Abedpour, Nima; Borchmann, Peter; Ullrich, Roland T.
    CSF1R⁺ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma
    In: Cancer Cell, Vol. 43, 2025, Nr. 8, pp. 1476 – 1494.e10
    DOI (Open Access)
  • Sakthivelu, Vignesh; Schmitt, Anna; Odenthal, Franka; Ndoci, Kristiano; Touet, Marian; Shaib, Ali H.; Chihab, Abdulla; Wani, Gulzar A.; Nieper, Pascal; Hartmann, Griffin G.; Pintelon, Isabel; Kisis, Ilmars; Boecker, Maike; Eckert, Naja M.; Ianicelli Caiaffa, Manoela; Ibruli, Olta; Weber, Julia; Maresch, Roman; Bebber, Christina M.; Chitsaz, Ali; Lütz, Anna; Kim Alves Carpinteiro, Mira; Morris, Kaylee M.; Franchino, Camilla A.; Benz, Jonas; Pérez-Revuelta, Laura; Soriano-Campos, Jorge A.; Huetzen, Maxim A.; Goergens, Jonas; Jevtic, Milica; Jahn-Kelleter, Hannah M.; Zempel, Hans; Placzek, Aleksandra; Hennrich, Alexandru A.; Conzelmann, Karl-Klaus; Tumbrink, Hannah L.; Hunold, Pascal; Isensee, Joerg; Werr, Lisa; Gaedke, Felix; Schauss, Astrid; Minère, Marielle; Müller, Marie; Fenselau, Henning; Liu, Yin; Heimsoeth, Alena; Gülcüler Balta, Gülce S.; Walczak, Henning; Frezza, Christian; Jachimowicz, Ron D.; George, Julie; Schmiel, Marcel; Brägelmann, Johannes; Hucho, Tim; von Karstedt, Silvia; Peifer, Martin; Annibaldi, Alessandro; Hänsel-Hertsch, Robert; Persigehl, Thorsten; Grüll, Holger; Sos, Martin L.; Reifenberger, Guido; Fischer, Matthias; Adriaensen, Dirk; Büttner, Reinhard; Sage, Julien; Brouns, Inge; Rad, Roland; Thomas, Roman K.; Anstötz, Max; Rizzoli, Silvio O.; Bergami, Matteo; Motori, Elisa; Reinhardt, Christian; Beleggia, Filippo
    Functional synapses between neurons and small cell lung cancer
    In: Nature, Vol. 646, 2025, Nr. 8087, pp. 1243 – 1253
    DOI (Open Access)
  • Sakthivelu, Vignesh; Schmitt, Anna; Odenthal, Franka; Ndoci, Kristiano; Touet, Marian; Shaib, Ali H.; Chihab, Abdulla; Wani, Gulzar A.; Nieper, Pascal; Hartmann, Griffin G.; Pintelon, Isabel; Kisis, Ilmars; Boecker, Maike; Eckert, Naja M.; Iannicelli Caiaffa, Manoela; Ibruli, Olta; Weber, Julia; Maresch, Roman; Bebber, Christina M.; Chitsaz, Ali; Lütz, Anna; Kim Alves Carpinteiro, Mira; Morris, Kaylee M.; Franchino, Camilla A.; Benz, Jonas; Pérez-Revuelta, Laura; Soriano-Campos, Jorge A.; Huetzen, Maxim A.; Goergens, Jonas; Jevtic, Milica; Jahn-Kelleter, Hannah M.; Zempel, Hans; Placzek, Aleksandra; Hennrich, Alexandru A.; Conzelmann, Karl-Klaus; Tumbrink, Hannah L.; Hunold, Pascal; Isensee, Joerg; Werr, Lisa; Gaedke, Felix; Schauss, Astrid; Minère, Marielle; Müller, Marie; Fenselau, Henning; Liu, Yin; Heimsoeth, Alena; Gülcüler Balta, Gülce S.; Walczak, Henning; Frezza, Christian; Jachimowicz, Ron D.; George, Julie; Schmiel, Marcel; Brägelmann, Johannes; Hucho, Tim; von Karstedt, Silvia; Peifer, Martin; Annibaldi, Alessandro; Hänsel-Hertsch, Robert; Persigehl, Thorsten; Grüll, Holger; Sos, Martin L.; Reifenberger, Guido; Fischer, Matthias; Adriaensen, Dirk; Büttner, Reinhard; Sage, Julien; Brouns, Inge; Rad, Roland; Thomas, Roman K.; Anstötz, Max; Rizzoli, Silvio O.; Bergami, Matteo; Motori, Elisa; Reinhardt, Christian; Beleggia, Filippo
    Publisher Correction : Functional synapses between neurons and small cell lung cancer
    In: Nature, Vol. 646, 2025, Nr. 8086, pp. E17
    DOI (Open Access)
  • Heger, Jan-Michel; Mattlener, Julia; Schneider, Jessica; Gödel, Philipp; Sieg, Noëlle; Ullrich, Fabian; Lewis, Richard; Bucaciuc-Mracica, Teodora; Schwarz, Roland F.; Rueß, Daniel; Ruge, Maximilian I.; Montesinos-Rongen, Manuel; Deckert, Martina; Blau, Tobias; Kutsch, Nadine; Balke-Want, Hyatt; Weiss, Jonathan; Becker, Kerstin; Reinhardt, H. Christian; Hallek, Michael; Borchmann, Peter; von Tresckow, Bastian; Borchmann, Sven
    Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNA
    In: Blood, Vol. 143, 2024, Nr. 6, pp. 522 – 534
    DOI
  • George, Julie; Maas, Lukas; Abedpour, Nima; Cartolano, Maria; Kaiser, Laura; Fischer, Rieke N.; Scheel, Andreas H.; Weber, Jan-Philipp; Hellmich, Martin; Bosco, Graziella; Volz, Caroline; Mueller, Christian; Dahmen, Ilona; John, Felix; Alves, Cleidson Padua; Werr, Lisa; Panse, Jens Peter; Kirschner, Martin; Engel-Riedel, Walburga; Jürgens, Jessica; Stoelben, Erich; Brockmann, Michael; Grau, Stefan; Sebastian, Martin; Stratmann, Jan A.; Kern, Jens; Hummel, Horst-Dieter; Hegedüs, Balazs; Schuler, Martin; Plönes, Till; Aigner, Clemens; Elter, Thomas; Toepelt, Karin; Ko, Yon-Dschun; Kurz, Sylke; Grohé, Christian; Serke, Monika; Höpker, Katja; Hagmeyer, Lars; Doerr, Fabian; Hekmath, Khosro; Strapatsas, Judith; Kambartel, Karl-Otto; Chakupurakal, Geothy; Busch, Annette; Bauernfeind, Franz-Georg; Griesinger, Frank; Luers, Anne; Dirks, Wiebke; Wiewrodt, Rainer; Luecke, Andrea; Rodermann, Ernst; Diel, Andreas; Hagen, Volker; Severin, Kai; Ullrich, Roland T.; Reinhardt, Hans Christian; Quaas, Alexander; Bogus, Magdalena; Courts, Cornelius; Nürnberg, Peter; Becker, Kerstin; Achter, Viktor; Büttner, Reinhard; Wolf, Jürgen; Peifer, Martin; Thomas, Roman K.
    Evolutionary trajectories of small cell lung cancer under therapy
    In: Nature, Vol. 627, 2024, Nr. 8005, pp. 880 – 889
    DOI (Open Access)
  • Bayraktar, Evren; Graf, Theresa; Ayuk, Francis A.; Beutel, Gernot; Penack, Olaf; Luft, Thomas; Brueder, Nicole; Castellani, Gastone; Reinhardt, H. Christian; Kröger, Nicolaus; Beelen, Dietrich W.; Turki, Amin T.
    Data-driven grading of acute graft-versus-host disease
    In: Nature Communications, Vol. 14, 2023, Nr. 1, 7799
    DOI, Online Full Text (Open Access)
  • Frank, Daria; Patnana, Pradeep Kumar; Vorwerk, Jan; Mao, Lianghao; Gopal, Lavanya Mokada; Jung, Noelle; Hennig, Thorben; Ruhnke, Leo; Frenz, Joris Maximillian; Kuppusamy, Maithreyan; Autry, Robert; Wei, Lanying; Sun, Kaiyan; Mohammed Ahmed, Helal Mohammed; Künstner, Axel; Busch, Hauke; Müller, Heiko; Hutter, Stephan; Hoermann, Gregor; Liu, Longlong; Xie, Xiaoqing; Al-Matary, Yahya; Nimmagadda, Subbaiah Chary; Charles Cano, Fiorella; Heuser, Michael; Thol, Felicitas; Göhring, Gudrun; Steinemann, Doris; Thomale, Jürgen; Leitner, Theo; Fischer, Anja; Rad, Roland; Röllig, Christoph; Altmann, Heidi; Kunadt, Desiree; Berdel, Wolfgang E.; Hüve, Jana; Neumann, Felix; Klingauf, Jürgen; Calderon, Virginie; Opalka, Bertram; Dührsen, Ulrich; Rosenbauer, Frank; Dugas, Martin; Varghese, Julian; Reinhardt, Hans Christian; von Bubnoff, Nikolas; Möröy, Tarik; Lenz, Georg; Batcha, Aarif M. N.; Giorgi, Marianna; Selvam, Murugan; Wang, Eunice; McWeeney, Shannon K.; Tyner, Jeffrey W.; Stölzel, Friedrich; Mann, Matthias; Jayavelu, Ashok Kumar; Khandanpour, Cyrus
    Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy
    In: Blood, Vol. 142, 2023, Nr. 25, pp. 2175 – 2191
    DOI (Open Access)
  • Gagelmann, Nico; Badbaran, Anita; Salit, Rachel B.; Schroeder, Thomas; Gurnari, Carmelo; Pagliuca, Simona; Panagiota, Victoria; Rautenberg, Christina; Cassinat, Bruno; Thol, Felicitas; Wolschke, Christine; Robin, Marie; Heuser, Michael; Rubio, Marie-Thérèse; Maciejewski, Jaroslaw P.; Reinhardt, Hans Christian; Scott, Bart L.; Kröger, Nicolaus
    Impact of TP53 on outcome of patients with myelofibrosis undergoing hematopoietic stem cell transplantation
    In: Blood, Vol. 141, 2023, Nr. 23, pp. 2901 – 2911
    DOI (Open Access)
  • Pindzola, Grace M.; Razzaghi, Raud; Tavory, Rachel N.; Nguyen, Hang T.; Morris, Vivian M.; Li, Moyi; Agarwal, Shreya; Huang, Bonnie; Okada, Takaharu; Reinhardt, Hans C.; Knittel, Gero; Kashkar, Hamid; Young, Ryan M.; Pittaluga, Stefania; Muppidi, Jagan R.
    Aberrant expansion of spontaneous splenic germinal centers induced by hallmark genetic lesions of aggressive lymphoma
    In: Blood, Vol. 140, 2022, Nr. 10, pp. 1119 – 1131
    DOI (Open Access)
  • Thomalla, D.; Beckmann, Laura; Grimm, C.; Oliverio, M.; Meder, L.; Herling, C.D.; Nieper, P.; Feldmann, T.; Merkel, O.; Lorsy, E.; da Palma Guerreiro, A.; von Jan, J.; Kisis, I.; Wasserburger, E.; Claasen, J.; Faitschuk-Meyer, E.; Altmüller, J.; Nürnberg, P.; Yang, T.-P.; Lienhard, M.; Herwig, R.; Kreuzer, K.-A.; Pallasch, C.P.; Büttner, R.; Schäfer, S.C.; Hartley, J.; Abken, H.; Peifer, M.; Kashkar, H.; Knittel, G.; Eichhorst, B.; Ullrich, R.T.; Herling, M.; Reinhardt, Hans Christian; Hallek, M.; Schweiger, M.R.; Frenzel, Lukas P.
    Deregulation and epigenetic modification of BCL2-family genes cause resistance to venetoclax in hematologic malignancies
    In: Blood, Vol. 140, 2022, Nr. 20, pp. 2113 – 2126
    DOI (Open Access)
  • Izquierdo, Elena; Vorholt, Daniela; Blakemore, Stuart; Sackey, Benedict; Nolte, Janica L.; Barbarino, Verena; Schmitz, Jan; Nickel, Nadine; Bachurski, Daniel; Lobastova, Liudmila; Nikolic, Milos; Michalik, Michael; Brinker, Reinhild; Merkel, Olaf; Franitza, Marek; Georgomanolis, Theodoros; Neuhaus, René; Koch, Maximilian; Nasada, Niklas; Knittel, Gero; Chapuy, Björn; Ludwig, Nicole; Meese, Eckart; Frenzel, Lukas; Reinhardt, Hans Christian; Peifer, Martin; Rebollido-Rios, Rocio; Bruns, Heiko; Krüger, Marcus; Hallek, Michael; Pallasch, Christian P.
    Extracellular vesicles and PD-L1 suppress macrophages, inducing therapy resistance in TP53-deficient B-cell malignancies
    In: Blood, Vol. 139, 2022, Nr. 25, pp. 3617 – 3629
    DOI (Open Access)
  • Wilke, Anne C.; Doebele, Carmen; Zindel, Alena; Lee, Kwang Seok; Rieke, Sara A.; Ceribelli, Michele; Comoglio, Federico; Phelan, James D.; Wang, James Q.; Pikman, Yana; Jahn, Dominique; Häupl, Björn; Schneider, Constanze; Scheich, Sebastian; Tosto, Frances A.; Bohnenberger, Hanibal; Stauder, Philipp; Schnütgen, Frank; Slabicki, Mikolaj; Coulibaly, Zana A.; Wolf, Sebastian; Bojarczuk, Kamil; Chapuy, Björn; Brandts, Christian H.; Stroebel, Philipp; Lewis, Caroline A.; Engelke, Michael; Xu, Xincheng; Kim, Hahn; Dang, Thanh Hung; Schmitz, Roland; Hodson, Daniel J.; Stegmaier, Kimberly; Urlaub, Henning; Serve, Hubert; Schmitt, Clemens A.; Kreuz, Fernando; Knittel, Gero; Rabinowitz, Joshua D.; Reinhardt, Hans Christian; Vander Heiden, Matthew G.; Thomas, Craig; Staudt, Louis M.; Zenz, Thorsten; Oellerich, Thomas
    SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma
    In: Blood, Vol. 139, 2022, Nr. 4, pp. 538 – 553
    DOI (Open Access)
  • Kohlhaas, Vivien; Blakemore, Stuart James; Al-Maarri, Mona; Nickel, Nadine; Pal, Martin; Roth, Andreas; Hövelmeyer, Nadine; Schäfer, Stephan C.; Knittel, Gero; Lohneis, Philipp; Nikolic, Milos; Wiederstein, Janica L.; Franitza, Marek; Georgomonolis, Theodoros; Reinart, Nina; Herling, Marco; Herling, Carmen; Hartmann, Elena M.; Rosenwald, Andreas; Klapper, Wolfram; Büttner, Reinhard; Moia, Riccardo; Rossi, Davide; Boldorini, Renzo; Gaidano, Gianluca; Frenzel, Lukas P.; Reinhardt, Hans Christian; Brüning, Jens C.; Hallek, Michael; Krüger, Marcus; Peifer, Martin; Pallasch, Christian P.; Wunderlich, F. Thomas
    Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1
    In: Blood, Vol. 137, 2021, Nr. 5, pp. 646 – 660
    DOI (Open Access)
  • Reimann, Maurice; Schrezenmeier, Jens; Richter-Pechanska, Paulina; Dolnik, Anna; Hick, Timon Pablo; Schleich, Kolja; Cai, Xiurong; Fan, Dorothy N. Y.; Lohneis, Philipp; Maßwig, Sven; Denker, Sophy; Busse, Antonia; Knittel, Gero; Flümann, Ruth; Childs, Dorothee; Childs, Liam; Gätjens-Sanchez, Ana-Maria; Bullinger, Lars; Rosenwald, Andreas; Reinhardt, Hans Christian; Schmitt, Clemens A.
    Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas
    In: Blood, Vol. 137, 2021, Nr. 20, pp. 2785 – 2799
    DOI (Open Access)
  • Flümann, Ruth; Rehkämper, Tim; Nieper, Pascal; Pfeiffer, Pauline; Holzem, Alessandra; Klein, Sebastian; Bhatia, Sanil; Kochanek, Moritz; Kisis, Ilmars; Pelzer, Benedikt W.; Ahlert, Heinz; Hauer, Julia; da Palma Guerreiro, Alexandra; Ryan, Jeremy A.; Reimann, Maurice; Riabinska, Arina; Wiederstein, Janica; Krüger, Marcus; Deckert, Martina; Altmüller, Janine; Klatt, Andreas R.; Frenzel, Lukas P.; Pasqualucci, Laura; Béguelin, Wendy; Melnick, Ari M.; Sander, Sandrine; Montesinos-Rongen, Manuel; Brunn, Anna; Lohneis, Philipp; Büttner, Reinhard; Kashkar, Hamid; Borkhardt, Arndt; Letai, Anthony; Persigehl, Thorsten; Peifer, Martin; Schmitt, Clemens A.; Reinhardt, Hans Christian; Knittel, Gero
    An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities
    In: Cancer Discovery, Vol. 2, 2021, Nr. 1, pp. 70 – 91
    DOI, Online Full Text (Open Access)
  • Bebber, Christina M.; Thomas, Emily S.; Stroh, Jenny; Chen, Zhiyi; Androulidaki, Ariadne; Schmitt, Anna; Höhne, Michaela N.; Stüker, Lukas; de Pádua Alves, Cleidson; Khonsari, Armin; Dammert, Marcel A.; Parmaksiz, Fatma; Tumbrink, Hannah L.; Beleggia, Filippo; Sos, Martin L.; Riemer, Jan; George, Julie; Brodesser, Susanne; Thomas, Roman K.; Reinhardt, H. Christian; von Karstedt, Silvia
    Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes
    In: Nature Communications, Vol. 12, 2021, Nr. 1, 2048
    DOI (Open Access)
  • Gremke, Niklas; Polo, Pierfrancesco; Dort, Aaron; Schneikert, Jean; Elmshäuser, Sabrina; Brehm, Corinna; Klingmüller, Ursula; Schmitt, Anna; Reinhardt, Hans Christian; Timofeev, Oleg; Wanzel, Michael; Stiewe, Thorsten
    mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
    In: Nature Communications, Vol. 11, 2020, Nr. 1, 4684
    DOI (Open Access)
  • Jachimowicz, Ron D.; Beleggia, Filippo; Isensee, Jörg; Velpula, Bhagya Bhavana; Goergens, Jonas; Bustos, Matias A.; Doll, Markus A.; Shenoy, Anjana; Checa-Rodriguez, Cintia; Wiederstein, Janica Lea; Baranes-Bachar, Keren; Bartenhagen, Christoph; Hertwig, Falk; Teper, Nizan; Nishi, Tomohiko; Schmitt, Anna; Distelmaier, Felix; Lüdecke, Hermann-Josef; Albrecht, Beate; Krüger, Marcus; Schumacher, Björn; Geiger, Tamar; Hoon, Dave S.B.; Huertas, Pablo; Fischer, Matthias; Hucho, Tim; Peifer, Martin; Ziv, Yael; Reinhardt, H. Christian; Wieczorek, Dagmar; Shiloh, Yosef
    UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors
    In: Cell, Vol. 176, 2019, Nr. 3, pp. 505 – 519.e22
    DOI (Open Access)
  • Knittel, Gero; Rehkämper, Tim; Korovkina, Darya; Liedgens, Paul; Fritz, Christian; Torgovnick, Alessandro; Al-Baldawi, Yussor; Al-Maarri, Mona; Cun, Yupeng; Fedorchenko, Oleg; Riabinska, Arina; Beleggia, Filippo; Nguyen, Phuong-Hien; Wunderlich, F. Thomas; Ortmann, Monika; Montesinos-Rongen, Manuel; Tausch, Eugen; Stilgenbauer, Stephan; Frenzel, Lukas P.; Herling, Marco; Herling, Carmen; Bahlo, Jasmin; Hallek, Michael; Peifer, Martin; Buettner, Reinhard; Persigehl, Thorsten; Reinhardt, H. Christian
    Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia
    In: Nature Communications, Vol. 8, 2017, Nr. 1, 153
    DOI (Open Access)
  • Knittel, Gero; Liedgens, Paul; Korovkina, Darya; Seeger, Jens M.; Al-Baldawi, Yussor; Al-Maarri, Mona; Fritz, Christian; Vlantis, Katerina; Bezhanova, Svetlana; Scheel, Andreas H.; Wolz, Olaf-Oliver; Reimann, Maurice; Möller, Peter; López, Cristina; Schlesner, Matthias; Lohneis, Philipp; Weber, Alexander N. R.; Trümper, Lorenz; Staudt, Louis M.; Ortmann, Monika; Pasparakis, Manolis; Siebert, Reiner; Schmitt, Clemens A.; Klatt, Andreas R.; Wunderlich, F. Thomas; Schäfer, Stephan C.; Persigehl, Thorsten; Montesinos-Rongen, Manuel; Odenthal, Margarete; Büttner, Reinhard; Frenzel, Lukas P.; Kashkar, Hamid; Reinhardt, H. Christian
    B-cell-specific conditional expression of Myd88p.L²⁵²P leads to the development of diffuse large B-cell lymphoma in mice
    In: Blood, Vol. 127, 2016, Nr. 22, pp. 2732 – 2741
    DOI (Open Access)
  • Dietlein, Felix; Kalb, Bastian; Jokic, Mladen; Noll, Elisa M.; Strong, Alexander; Tharun, Lars; Ozretić, Luka; Künstlinger, Helen; Kambartel, Kato; Randerath, Winfried J.; Jüngst, Christian; Schmitt, Anna; Torgovnick, Alessandro; Richters, André; Rauh, Daniel; Siedek, Florian; Persigehl, Thorsten; Mauch, Cornelia; Bartkova, Jirina; Bradley, Allan; Sprick, Martin R.; Trumpp, Andreas; Rad, Roland; Saur, Dieter; Bartek, Jiri; Wolf, Jürgen; Büttner, Reinhard; Thomas, Roman K.; Reinhardt, H. Christian
    A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer
    In: Cell, Vol. 162, 2015, Nr. 1, pp. 146 – 159
    DOI (Open Access)
  • George, Julie; Lim, Jing Shan; Jang, Se Jin; Cun, Yupeng; Ozretia, Luka; Kong, Gu; Leenders, Frauke; Lu, Xin; Fernández-Cuesta, Lynnette; Bosco, Graziella; Müller, Christian; Dahmen, Ilona; Jahchan, Nadine S.; Park, Kwon-Sik; Yang, Dian; Karnezis, Anthony N.; Vaka, Dedeepya; Torres, Angela; Wang, Maia Segura; Korbel, Jan O.; Menon, Roopika; Chun, Sung-Min; Kim, Deokhoon; Wilkerson, Matt; Hayes, Neil; Engelmann, David; Pützer, Brigitte; Bos, Marc; Michels, Sebastian; Vlasic, Ignacija; Seidel, Danila; Pinther, Berit; Schaub, Philipp; Becker, Christian; Altmüller, Janine; Yokota, Jun; Kohno, Takashi; Iwakawa, Reika; Tsuta, Koji; Noguchi, Masayuki; Muley, Thomas; Hoffmann, Hans; Schnabel, Philipp A.; Petersen, Iver; Chen, Yuan; Soltermann, Alex; Tischler, Verena; Choi, Chang-Min; Kim, Yong-Hee; Massion, Pierre P.; Zou, Yong; Jovanovic, Dragana; Kontic, Milica; Wright, Gavin M.; Russell, Prudence A.; Solomon, Benjamin; Koch, Ina; Lindner, Michael; Muscarella, Lucia A.; La Torre, Annamaria; Field, John K.; Jakopovic, Marko; Knezevic, Jelena; Castaños-Vélez, Esmeralda; Roz, Luca; Pastorino, Ugo; Brustugun, Odd-Terje; Lund-Iversen, Marius; Thunnissen, Erik; Köhler, Jens; Schuler, Martin; Botling, Johan; Sandelin, Martin; Sanchez-Cespedes, Montserrat; Salvesen, Helga B.; Achter, Viktor; Lang, Ulrich; Bogus, Magdalena; Schneider, Peter M.; Zander, Thomas; Ansén, Sascha; Hallek, Michael; Wolf, Jürgen; Vingron, Martin; Yatabe, Yasushi; Travis, William D.; Nürnberg, Peter; Reinhardt, Christian; Perner, Sven; Heukamp, Lukas; Büttner, Reinhard; Haas, Stefan A.; Brambilla, Elisabeth; Peifer, Martin; Sage, Julien; Thomas, Roman K.
    Comprehensive genomic profiles of small cell lung cancer
    In: Nature, Vol. 524, 2015, Nr. 7563, pp. 47 – 53
    DOI (Open Access)
  • Dietlein, Felix; Kalb, Bastian; Jokic, Mladen; Noll, Elisa M.; Strong, Alexander; Tharun, Lars; Ozretić, Luka; Künstlinger, Helen; Kambartel, Kato; Randerath, Winfried J.; Jüngst, Christian; Schmitt, Anna; Torgovnick, Alessandro; Richters, André; Rauh, Daniel; Siedek, Florian; Persigehl, Thorsten; Mauch, Cornelia; Bartkova, Jirina; Bradley, Allan; Sprick, Martin R.; Trumpp, Andreas; Rad, Roland; Saur, Dieter; Bartek, Jiri; Wolf, Jürgen; Büttner, Reinhard; Thomas, Roman K.; Reinhardt, H. Christian
    Erratum: A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer
    In: Cell, Vol. 162, 2015, Nr. 5, pp. 1169
    DOI (Open Access)
  • Dietlein, Felix; Thelen, Lisa; Jokic, Mladen; Jachimowicz, Ron D.; Ivan, Laura; Knittel, Gero; Leeser, Uschi; van Oers, Johanna; Edelmann, Winfried; Heukamp, Lukas C.; Reinhardt, H. Christian
    A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDC
    In: Cancer Discovery, Vol. 4, 2014, Nr. 5, pp. 592 – 605
    DOI (Open Access)
  • Janes, Kevin A.; Reinhardt, H. Christian; Yaffe, Michael B.
    Cytokine-Induced Signaling Networks Prioritize Dynamic Range over Signal Strength
    In: Cell, Vol. 135, 2008, Nr. 2, pp. 343 – 354
    DOI (Open Access)
  • Wilker, Erik W.; van Vugt, Marcel A. T. M.; Artim, Steven A.; Huang, Paul H.; Petersen, Christian P.; Reinhardt, H. Christian; Feng, Yun; Sharp, Phillip A.; Sonenberg, Nahum; White, Forest M.; Yaffe, Michael B.
    14-3-3σ controls mitotic translation to facilitate cytokinesis
    In: Nature, Vol. 446, 2007, Nr. 7133, pp. 329 – 332
    DOI
  • Reinhardt, H. Christian; Aslanian, Aaron S.; Lees, Jacqueline A.; Yaffe, Michael B.
    p53-Deficient Cells Rely on ATM- and ATR-Mediated Checkpoint Signaling through the p38MAPK/MK2 Pathway for Survival after DNA Damage
    In: Cancer Cell, Vol. 11, 2007, Nr. 2, pp. 175 – 189
    DOI (Open Access)
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