ZMB Research Program Oncology

ZMB Research Program
Oncology

Oncology

The concept of this research programme is to understand fundamental processes in tumor biology in order to develop novel molecularly defined and rationally applied cancer treatments. Participating researchers from biology, experimental and clinical medicine study tumors as "biological systems" and so called "neo-organs". A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumor development, growth, progression and tumor cell migration.

A first focus lies on the investigation of the behaviour of malignant cells, their signalling interactions, cell death (apoptosis) and proliferation rates, as well as changes in their differentiation program. Moreover, as most drug targets are proteins, researchers in this program focus on the molecular analysis of cancer-relevant proteins. Protein function is linked to expression levels, specific subcellular localization, interaction with other proteins and post-translational modifications. These events contribute to the various functional properties that are important for the malignant transformation of cells.

A second focus lies on the investigation of the molecular details of migration and metastasis of tumor cells, as well as cellular responses to cell damage. In addition, in cooperation with researchers from the Program on Immunology and Infectious Diseases, the interactions between the immune system and tumours are of particular interest.

Current Selected Publications since 2025

    Journal articles

  • Peng, JuanFei; Yang, JiaJin; Antonopoulou, Georgia; Fang, Rui; Adhikari, Bikash; Vogt, Markus; Wolf, Elmar; Sun, Chong; Du, Shangce; Godfrey, Laura; Gupta, Aayush; Trajkovic-Arsic, Marija; Teichmann, Nicole; Grünwald, Barbara T.; Krebs, Niklas; Steiger, Katja; Mogler, Carolin; Althoff, Kristina; Wang, Xin; Giglio, Giovanni; Liffers, Sven-Thorsten; Savvatakis, Konstantinos; Braren, Rickmer; Lawlor, Rita T.; Scarpa, Aldo; Behrens, Diana; Lang, Karl S.; Cheung, Phyllis F.; Siveke, Jens T.
    Combined targeted and epigenetic-based therapy enhances antitumor immunity by stabilizing GATA6-dependent MHCI expression in pancreatic ductal adenocarcinoma
    In: Nature Communications, Vol. 17, 2026, Nr. 1, 1476
    DOI (Open Access)
  • Keyl, Julius; Hosch, René; Hörst, Fabian; Keyl, Philipp; Dada, Amin; Haubold, Johannes; Straus, Jannis; Egger, Jan; Stahler, Arndt; Kurreck, Annika; Ballhausen, Alexej; Stintzing, Sebastian; Fruehauf, Stefan; Müller, Lothar; Alig, Annabel H S; Trarbach, Tanja; Hartmann, Sylvia; Nensa, Felix; Kleesiek, Jens; Kasper, Stefan; Schuler, Martin; Modest, Dominik P.
    Deep Learning-Derived Sarcopenia Marker Predicts Benefit from Anti-EGFR Therapy in Patients with RAS Wild-type Metastatic Colorectal Cancer
    In: Clinical Cancer Research, Vol. 32, 2026, Nr. 5, pp. 938 – 946
    DOI (Open Access)
  • Dummer, Reinhard; Guo, Jun; Luke, Jason J; Carlino, Matteo S; Schadendorf, Dirk; Khattak, Muhammad A; Hauschild, Axel; Ascierto, Paolo A; Chen, Yu; Shin, Sang Joon; Rutkowski, Piotr; Luo, Zhiguo; Chen, Jing; Rivalland, Gareth; Coetzee, Corlia; Ribas, Antoni; Mujika, Karmele; Markel, Gal; Villarroel, Rodrigo U; Dizdar, Omer; Caglevic, Christian; Grebennik, Dmitri; Donovan, Kevin; Krepler, Clemens; Long, Georgina V
    Vibostolimab coformulated with pembrolizumab versus pembrolizumab alone as adjuvant therapy for high-risk stage IIB–IV melanoma (KEYVIBE-010) : A randomised, double-blind, phase 3 study
    In: The Lancet Oncology, Vol. 27, 2026, Nr. 3, pp. 327 – 339
    DOI (Open Access)
  • Braun, Lukas M.; Giesler, Sophie; Andrieux, Geoffroy; Riemer, Roxane; Talvard-Balland, Nana; Duquesne, Sandra; Rückert, Tamina; Unger, Susanne; Kreutmair, Stefanie; Zwick, Melissa; Follo, Marie; Hartmann, Alina; Osswald, Natascha; Melchinger, Wolfgang; Chapman, Stefanie; Hutchinson, James A.; Haferkamp, Sebastian; Torster, Leopold; Kött, Julian; Gebhardt, Christoffer; Hellwig, Dirk; Karantzelis, Nikolaos; Wallrabenstein, Till; Lowinus, Theresa; Yücel, Mehtap; Brehm, Niklas; Rawluk, Justyna; Pfeifer, Dietmar; Bronsert, Peter; Rogg, Manuel; Mattern, Sven; Heikenwälder, Mathias; Fusco, Stefano; Malek, Nisar P.; Singer, Stephan; Schmitt-Graeff, Annette; Ceteci, Fatih; Greten, Florian R.; Blazar, Bruce R.; Boerries, Melanie; Köhler, Natalie; Duyster, Justus; Ihorst, Gabriele; Lassmann, Silke; Keye, Philip; Minguet, Susana; Schadendorf, Dirk; Ugurel, Selma; Rafei-Shamsabadi, David; Thimme, Robert; Hasselblatt, Peter; Bengsch, Bertram; Schell, Christoph; Pearce, Erika L.; Meiss, Frank; Becher, Burkhard; Funke-Lorenz, Carolin; Placke, Jan-Malte; Apostolova, Petya; Zeiser, Robert
    Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity
    In: Cancer Cell, Vol. 43, 2025, Nr. 2, pp. 269 – 291.e19
    DOI (Open Access)
  • Long, Georgina V.; Garnett-Benson, Charlie; Dolfi, Sonia; Ascierto, Paolo A.; Guo, Jun; Tarhini, Ahmad A.; Chandra, Sunandana; Muñoz-Couselo, Eva; Del Vecchio, Michele; de Melo, Andreia Cristina; Callahan, Margaret; Gogas, Helen; Dummer, Reinhard; Schadendorf, Dirk; Koelblinger, Peter; Quereux, Gaelle; Thomas, Ioannis; Yu, Jia Xin; Fisher, Andrew; Wang, Bonnie; Djidel, Patrick; Chouzy, Armand; Semaan, Mark; Chen, Bohang; Cheong, Alicia M. Y.; Tawbi, Hussein A.
    Adjuvant nivolumab and relatlimab in stage III/IV melanoma : the randomized phase 3 RELATIVITY-098 trial
    In: Nature Medicine, Vol. 31, 2025, Nr. 12, pp. 4301 – 4309
    DOI (Open Access)
  • Hricak, Hedvig; Mayerhoefer, Marius E; Herrmann, Ken; Lewis, Jason S; Pomper, Martin G; Hess, Christopher P; Riklund, Katrine; Scott, Andrew M; Weissleder, Ralph
    Advances and challenges in precision imaging
    In: The Lancet Oncology, Vol. 26, 2025, Nr. 1, pp. e34 – e45
    DOI, Online Full Text (Open Access)
  • Faubert, Brandon; Tasdogan, Alpaslan
    Approaches to stable isotope tracing and in vivo metabolomics in the cancer clinic
    In: The EMBO Journal, Vol. 44, 2025, Nr. 12, pp. 3303 – 3306
    DOI (Open Access)
  • Lopez, Juanita; Powles, Thomas; Braiteh, Fadi; Siu, Lillian L.; LoRusso, Patricia; Friedman, Claire F.; Balmanoukian, Ani S.; Gordon, Michael; Yachnin, Jeffrey; Rottey, Sylvie; Karydis, Ioannis; Fisher, George A.; Schmidt, Marcus; Schuler, Martin; Sullivan, Ryan J.; Burris, Howard A.; Galvao, Vladimir; Henick, Brian S.; Dirix, Luc; Jaeger, Dirk; Ott, Patrick A.; Wong, Kit Man; Jerusalem, Guy; Schiza, Aglaia; Fong, Lawrence; Steeghs, Neeltje; Leidner, Rom S.; Rittmeyer, Achim; Laurie, Scott A.; Gort, Eelke; Aljumaily, Raid; Melero, Ignacio; Sabado, Rachel L.; Rhee, Ina; Mancuso, Michael R.; Muller, Lars; Fine, Gregg D.; Yadav, Mahesh; Kim, Leesun; Leveque, Vincent J. P.; Robert, Alberto; Darwish, Martine; Qi, Ting; Zhu, Jiawen; Zhang, Jingbin; Twomey, Patrick; Rao, Gautham K.; Low, Donald W.; Petry, Chris; Lo, Amy A.; Schartner, Jill M.; Delamarre, Lélia; Mellman, Ira; Löwer, Martin; Müller, Felicitas; Derhovanessian, Evelyna; Cortini, Andrea; Manning, Luisa; Maurus, Daniel; Brachtendorf, Sebastian; Lörks, Verena; Omokoko, Tana; Godehardt, Eva; Becker, Dirk; Hawner, Christine; Wallrapp, Christine; Albrecht, Christian; Kröner, Christoph; Tadmor, Arbel D.; Diekmann, Jan; Vormehr, Mathias; Jork, Anette; Paruzynski, Anna; Lang, Maren; Blake, Jonathon; Hennig, Oliver; Kuhn, Andreas N.; Sahin, Ugur; Türeci, Özlem; Camidge, D. Ross
    Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial
    In: Nature Medicine, Vol. 31, 2025, Nr. 1, pp. 152 – 164
    DOI (Open Access)
  • Stahl, David; Gödel, Philipp; Balke-Want, Hyatt; Gholamipoorfard, Rahil; Segbers, Paul; Tetenborg, Luis; Koker, Mirjam; Dörr, Janina; Gregor, Lisa; Bachurski, Daniel; Rose, France; Simon, Adrian G.; Good, Zinaida; Jakob, Josefine; Häupl, Björn; Nill, Marieke; Flümann, Ruth; Riet, Tobias; Lange, Dinah; Blakemore, Stuart J.; Baurmann, Herrad; Voltin, Conrad-Amadeus; Potter, Nicole; Schlözer, Lilli; Freihammer, Max; Wagener-Ryczek, Svenja; Iuga, Andra-Iza; Heger, Jan-Michel; Ludwig, Hanna; Schleifenbaum, Julia K.; Propp, Jessica; Bröckelmann, Paul J.; Jachimowicz, Ron D.; Knittel, Gero; Borchmann, Sven; Merkelbach-Bruse, Sabine; Pallasch, Christian; Peifer, Martin; Rybniker, Jan; Quaas, Alexander; Nitz, Mark; Brägelmann, Johannes; Müller, Werner; Persigehl, Thorsten; Bozek, Katarzyna; Theobald, Sebastian J.; Büttner, Reinhard; Oellerich, Thomas; Hallek, Michael; Kobold, Sebastian; Chmielewski, Markus; Reinhardt, Christian; Mackall, Crystal; Abedpour, Nima; Borchmann, Peter; Ullrich, Roland T.
    CSF1R⁺ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma
    In: Cancer Cell, Vol. 43, 2025, Nr. 8, pp. 1476 – 1494.e10
    DOI (Open Access)
  • Syeda, Mahrukh M; Long, Georgina V; Garrett, James; Atkinson, Victoria; Santinami, Mario; Schadendorf, Dirk; Hauschild, Axel; Millward, Michael; Mandala, Mario; Chiarion-Sileni, Vanna; Smylie, Michael; Manikhas, Georgy M; Dummer, Reinhard; Wiggins, Jennifer M; Ali, Saim; Adnaik, Sachin Bajirao; Tan, Monique; Dajee, Maya; Polsky, David
    Clinical validation of droplet digital PCR assays in detecting BRAFV⁶⁰⁰-mutant circulating tumour DNA as a prognostic biomarker in patients with resected stage III melanoma receiving adjuvant therapy (COMBI-AD) : A biomarker analysis from a double-blind, randomised phase 3 trial
    In: The Lancet Oncology, Vol. 26, 2025, Nr. 5, pp. 641 – 653
    DOI
  • Berg, Victoria; Lollies, Anna; Schneider, Markus; Johansson, Patricia; Weniger, Marc A.; Albertini, Emma; Facchetti, Fabio; Ascani, Stefano; Moawia, Abubakar; Bens, Susanne; Fischer, Anja; Siebert, Reiner; Klapper, Wolfram; Lorenzi, Luisa; Tiacci, Enrico; Hartmann, Sylvia; Budeus, Bettina; Hansmann, Martin-Leo; Küppers, Ralf
    Common origin and somatic mutation patterns of composite lymphomas and leukemias
    In: Leukemia, Vol. 39, 2025, Nr. 8, pp. 1960 – 1971
    DOI (Open Access)
  • Kolb, Antonia; Kulis-Mandic, Ana-Marija; Klein, Matthias; Stastny, Anna; Haist, Maximilian; Votteler, Vanessa; Weidenthaler-Barth, Beate; Sinnberg, Tobias; Sucker, Antje; Allies, Gabriele; Albrecht, Jessica Lea; Tasdogan, Alpaslan; Tuettenberg, Andrea; Gaida, Matthias M.; Deppermann, Carsten; Stege, Henner; Schadendorf, Dirk; Grabbe, Stephan; Schulze-Osthoff, Klaus; Kramer, Daniela
    Constitutive expression of the transcriptional co-activator IκBζ promotes melanoma growth and immunotherapy resistance
    In: Nature Communications, Vol. 16, 2025, Nr. 1, 5387
    DOI (Open Access)
  • Haggenmüller, Sarah; Wies, Christoph; Abels, Julia; Winterstein, Jana T.; Heinlein, Lukas; Nogueira Garcia, Carina; Utikal, Jochen S.; Wohlfeil, Sebastian A.; Meier, Friedegund; Hobelsberger, Sarah; Gellrich, Frank F.; Sergon, Mildred; Hauschild, Axel; French, Lars E.; Heinzerling, Lucie; Schlager, Justin G.; Ghoreschi, Kamran; Schlaak, Max; Hilke, Franz J.; Poch, Gabriela; Korsing, Sören; Sarfert, Cosimo; Berking, Carola; Heppt, Markus V.; Erdmann, Michael; Haferkamp, Sebastian; Drexler, Konstantin; Schadendorf, Dirk; Sondermann, Wiebke; Goebeler, Matthias; Schilling, Bastian; Kather, Jakob Nikolas; Fröhling, Stefan; Llamas-Velasco, Mar; Requena, Luis C.; Ferrara, Gerardo; Fernandez-Figueras, Maite; Fraitag, Sylvie; Müller, Cornelia S. L.; Starz, Hans; Kutzner, Heinz; Barnhill, Raymond; Carr, Richard; Resnik, Kenneth S.; Braun, Stephan Alexander; Holland-Letz, Tim; Brinker, Titus J.
    Discordance, accuracy and reproducibility study of pathologists’ diagnosis of melanoma and melanocytic tumors
    In: Nature Communications, Vol. 16, 2025, Nr. 1, 789
    DOI (Open Access)
  • Meder, Lydia; Orschel, Charlotte I.; Bouchez, Cyrielle L.; Gholamipoorfard, Rahil; Orschel, Claudia V.; Stahl, David; Kreer, Christoph; Koker, Mirjam; Nill, Marieke; Kocak, Ilayda G.; Noh, Ka-Won; Zhao, Xinlei; Ullrich, Leon; Häupl, Björn; Jakob, Josefine; Eich, Marie-Lisa; Florin, Alexandra; Grüll, Holger; Wolf, Jürgen; Beleggia, Filippo; Büttner, Reinhard; Oellerich, Thomas; Klein, Florian; Brägelmann, Johannes; Reinhardt, Christian; Abedpour, Nima; Ullrich, Roland T.
    ERBB2 signaling drives immune cell evasion and resistance against immunotherapy in small cell lung cancer
    In: Nature Communications, Vol. 16, 2025, Nr. 1, 10983
    DOI (Open Access)
  • Schuler, Martin
    Facts and Hopes in Neoadjuvant Immunotherapy Combinations in Resectable Non-Small Cell Lung Cancer
    In: Clinical Cancer Research, Vol. 31, 2025, Nr. 5, pp. 801 – 807
    DOI
  • Wolchok, Jedd D.; Chiarion-Sileni, Vanna; Rutkowski, Piotr; Cowey, C. Lance; Schadendorf, Dirk; Wagstaff, John; Queirolo, Paola; Dummer, Reinhard; Butler, Marcus O.; Hill, Andrew G.; Postow, Michael A.; Gaudy-Marqueste, Caroline; Medina, Theresa; Lao, Christopher D.; Walker, John; Márquez-Rodas, Iván; Haanen, John B. A. G.; Guidoboni, Massimo; Maio, Michele; Schöffski, Patrick; Carlino, Matteo S.; Sandhu, Shahneen; Lebbé, Céleste; Ascierto, Paolo A.; Long, Georgina V.; Ritchings, Corey; Nassar, Ayman; Askelson, Margarita; Benito, Melanie Pe; Wang, Wenjia; Hodi, F. Stephen; Larkin, James; CheckMate 067 Investigators
    Final, 10-Year Outcomes with Nivolumab plus Ipilimumab in Advanced Melanoma
    In: The New England Journal of Medicine, Vol. 392, 2025, Nr. 1, pp. 11 – 22
    DOI, Online Full Text (Open Access)
  • Pylaeva, Ekaterina; Tollrian, Lea; Riedesel, Jana; Shevchuk, Olga; Thiel, Ilona; Ozel, Irem; Kabankova, Nastassia; Voß, Hannah; Siebels, Bente; Schlüter, Hartmut; Haist, Corinna; Hanenberg, Helmut; Mattheis, Stefan; Kürten, Cornelius; Sperandio, Markus; Kehrmann, Jan; Engel, Daniel Robert; Lang, Stephan; Jablonska, Jadwiga
    G-CSF/NAMPT signaling drives neutrophil dysfunction and enhances bacterial infection susceptibility in cancer patients
    In: Nature Communications, Vol. 16, 2025, Nr. 1, 11137
    DOI (Open Access)
  • Ronnacker, Julian; Müller, Philippe J.; Mikesch, Jan-Henrik; Zukunft, Sven; Weinbergerová, Barbora; Šrámek, Jiří; Valka, Jan; Novak, Jan; Zak, Pavel; Szotkowski, Tomas; Koristek, Zdenek; Krekeler, Carolin; Unglaub, Julia M.; Sauer, Tim; Ruhnke, Leo; Kraus, Sabrina; Schaffrath, Judith; Müller, Lutz P.; Kaes, Sabrina; Niemann, Dirk; Fransecky, Lars; Hess, Patrick P.; Crysandt, Martina; Jost, Edgar; Millo, Joana; Gaertner, Johannes; Repp, Roland; Jentzsch, Madlen; Hoppe, Lea; Klein, Stefan; Modemann, Franziska; Michalowski, Nina; Fischbach, Klaudia; Blau, Wolfgang; Ruhs, Marion; Ritter, Markus; Lohmeyer, Julian; Steffen, Björn; Hauser, Sarah; Kaufmann, Martin; Krause, Stefan W.; Knabe, Ricarda; Spiekermann, Karsten; Serve, Hubert; Platzbecker, Uwe; Baldus, Claudia D.; Müller-Tidow, Carsten; Lenz, Georg; Reinhardt, Christian; Mayer, Jirí; Bornhäuser, Martin; Röllig, Christoph; Schliemann, Christoph; Hanoun, Maher
    Gemtuzumab ozogamicin in first-line treatment of CBF-AML : Insights from a retrospective multi-center analysis
    In: Leukemia, Vol. 39, 2025, Nr. 9, pp. 2174 – 2180
    DOI (Open Access)
  • Rausch, Tobias; Schäfer, Hendrik; Bein, Julia; Mölder, Felix; Beeck, Lilian Kara; Kölsch, Bernd; Borchert, Sabrina; Benes, Vladimir; Halbsguth, Teresa; Brunnberg, Uta; Oellerich, Thomas; Tousseyn, Thomas; Ponzoni, Maurilio; Köster, Johannes; Hansmann, Martin-Leo; Küppers, Ralf; Hartmann, Sylvia
    Genetic lesions in nodular lymphocyte-predominant Hodgkin lymphoma and T cell/histiocyte-rich large B-cell lymphoma identified by whole genome sequencing
    In: Leukemia, Vol. 39, 2025, Nr. 9, pp. 2215 – 2225
    DOI (Open Access)
  • Serrano, César; Bauer, Sebastian; Blay, Jean-Yves; Casali, Paolo G.; Cicala, Carlo M.; Dei Tos, Angelo P.; Digklia, Antonia; Gelderblom, Hans; Italiano, Antoine; Jones, Robin L.; Kasper, Bernd; Kyriazoglou, Anastasios; Le Loarer, Francois; Martín-Broto, Javier; Napolitano, Andrea; Rutkowski, Piotr; Stacchiotti, Silvia; Tap, William; Thomas, David; Thway, Khin; Valverde, Claudia; Van Der Graaf, Winette T. A.; Wardelmann, Eva; Bovée, Judith V. M. G.
    Guidelines for Next-Generation Sequencing in Sarcoma Diagnosis and Treatment : A Consensus Review
    In: JAMA Oncology, Vol. 11, 2025, Nr. 12, pp. 1527 – 1537
    DOI
  • Cai, Ling; Hammond, Nia G.; Tasdogan, Alpaslan; Alsamraae, Massar; Yang, Chendong; Cameron, Robert B.; Quan, Peiran; Solmonson, Ashley; Gu, Wen; Pachnis, Panayotis; Kaur, Mayher; Chang, Brianna K.; Zhou, Qin; Hensley, Christopher T.; Do, Quyen N.; Martins Nascentes Melo, Luiza; Ubellacker, Jessalyn M.; Kaushik, Akash; Clare, Maia G.; Alcazar, Isabel N.; Kurylowicz, Katarzyna; Marcuccilli, Joseph D.; Allies, Gabriele; Kutritz, Andrea; Klode, Joachim; Ramesh, Vijayashree; Rogers, Thomas J.; Rao, Aparna D.; Crentsil, Hannah E.; Li, Hong; Brister, Fang; McDaniel, Phyllis; Xu, Xiaohong; Evers, Bret M.; Zacharias, Lauren G.; Sudderth, Jessica; Xu, Jian; Mathews, Thomas P.; Oliver, Dwight; Minna, John D.; Waters, John; Morrison, Sean J.; Kernstine, Kemp H.; Faubert, Brandon; DeBerardinis, Ralph J.
    High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non-Small Cell Lung Cancer in Patients
    In: Cancer Discovery, Vol. 15, 2025, Nr. 4, pp. 702 – 716
    DOI (Open Access)
  • Lei, Kuan Cheok; Srinivas, Nalini; Chandra, Mitalee; Serobyan, Vahan; Ugurel, Selma; Hoffmann, Daniel; Kervarrec, Thibault; Lui, Weng-Onn; Becker, Jürgen C.
    High-resolution spatial transcriptomics uncover epidermal-dermal divergences in Merkel cell carcinoma : Spatial context reshapes the gene expression landscape
    In: Oncogene, Vol. 44, 2025, Nr. 47, pp. 4615 – 4625
    DOI (Open Access)
  • Richter, Mathis; Diesterbeck, Eva; Pylaeva, Ekaterina; Labusek, Nicole; Köster, Christian; Nagel, Dennis; Karsch, Laura; Fischer, Alexa Josephine; Sous, Marah; Jung, Marcel; Chevre, Raphael; Hagemann, Nina; Andersson, Erik Axel; Ek, C. Joakim; Singh, Vikramjeet; Hermann, Dirk M.; Gunzer, Matthias; Jablonska, Jadwiga; Felderhoff-Müser, Ursula; Bendix, Ivo; Soehnlein, Oliver; Herz, Josephine
    Hypoxic-ischemic brain injury in neonatal mice sequentially recruits neutrophils with dichotomous phenotype and function
    In: Nature Communications, Vol. 16, 2025, Nr. 1, 9696
    DOI (Open Access)
  • Androulidaki, Ariadne; Liu, Fanyu; Bebber, Christina M.; Kisis, Ilmars; Sakthivelu, Vignesh; Hunold, Pascal; Koerner, Lioba; Dahlhaus, Alina; Yapici, Fatma Isil; Grimm, Christina; Pacholewska, Alicja; Tishina, Sofya; Doskotz, Franka; Torres Fernández, Lucia A.; Stroh, Jenny; Abdallah, Ali T.; Beck, Julia; Mulalic, Lejla; Schmitt, Anna; Grüll, Holger; Persigehl, Thorsten; Quaas, Alexander; Peifer, Martin; Brägelmann, Johannes; Reinhardt, Christian; Nieper, Pascal; Hänsel-Hertsch, Robert; Thomas, Roman K.; George, Julie; Schweiger, Michal R.; Pasparakis, Manolis; Beleggia, Filippo; von Karstedt, Silvia
    Lack of caspase 8 directs neuronal progenitor-like reprogramming and small cell lung cancer progression
    In: Nature Communications, Vol. 16, 2025, Nr. 1, 11280
    DOI (Open Access)
  • Yeh, Hsi-Wen; DelGaudio, Nicole Lauren; Uygur, Beste; Millet, Alon; Khan, Artem; Unlu, Gokhan; Xiao, Michael; Timson, Rebecca C.; Li, Caifan; Ozcan, Kerem; Smith, Karl W.; Nascentes Melo, Luiza Martins; Allies, Gabriele; Basturk, Olca; Sickmann, Albert; Bayraktar, Erol C.; Possemato, Richard; Tasdogan, Alpaslan; Birsoy, Kıvanç
    Mitochondrial Glutathione Import Enables Breast Cancer Metastasis via Integrated Stress Response Signaling
    In: Cancer Discovery, Vol. 15, 2025, Nr. 12, pp. 2437 – 2449
    DOI, Online Full Text (Open Access)
  • Skoulidis, Ferdinandos; Li, Bob T.; de Langen, Adrianus Johannes; Hong, David S.; Lena, Herve; Wolf, Juergen; Dy, Grace K.; Curioni Fontecedro, Alessandra; Tomasini, Pascale; Velcheti, Vamsidhar; van der Wekken, Anthonie J.; Dooms, Christophe; Paz-Ares Rodriguez, Luis; Mountzios, Giannis; Sacher, Adrian; Nadal, Ernest; Couraud, Sebastien; Kim, Sang-We; O’Byrne, Kenneth; Rocco, Danilo; Toyozawa, Ryo; Chmielewska, Izabela; Lindsay, Colin R.; Hindoyan, Antreas; Mukundan, Lata; Wilmanski, Tomasz; Anderson, Abraham; Ardito-Abraham, Christine; Pati, Amrita; Reddy, Anita; Mehta, Bhakti; Schuler, Martin
    Molecular determinants of sotorasib clinical efficacy in KRASG12C-mutated non-small-cell lung cancer
    In: Nature Medicine, Vol. 31, 2025, Nr. 8, pp. 2755 – 2767
    DOI (Open Access)
  • Hauschild, Axel; Garbe, Claus; Ascierto, Paolo Antonio; Demidov, Lev; Dreno, Brigitte; Dummer, Reinhard; Eggermont, Alexander; Forsea, Ana-Maria; Gebhardt, Christoffer; Gershenwald, Jeffrey E; Hamid, Omid; Hoeller, Christoph; Kandolf, Lidija; Kaufmann, Roland; Kirkwood, John M; Lebbé, Celeste; Long, Georgina V; Malvehy, Josep; Martin-Algarra, Salvador; McArthur, Grant; Neyns, Bart; Richtig, Erika; Robert, Caroline; Schadendorf, Dirk; Scolyer, Richard; Sondak, Vernon K; Wainstein, Alberto; Weichenthal, Michael; Nuti, Paolo; Melanoma World Society Study Group
    Neoadjuvant or perioperative therapy for melanoma metastasis in clinical practice : An international survey
    In: The Lancet Oncology, Vol. 26, 2025, Nr. 1, pp. 12 – 14
    DOI
  • Klein, Lukas; Tu, Mengyu; Krebs, Niklas; Urbach, Laura; Grimm, Daniela; Latif, Muhammad Umair; Penz, Frederike; Blandau, Anna; Wu, Xueyan; Samuel, Rebecca Diya; Küffer, Stefan; Wegwitz, Florian; Chan, Nathan; Aliar, Kazeera; Vyas, Foram; Kishore, Uday; Hessmann, Elisabeth; Trumpp, Andreas; Espinet, Elisa; Papantonis, Argyris; Khokha, Rama; Ellenrieder, Volker; Grünwald, Barbara; Singh, Shiv K.
    Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer
    In: Nature Communications, Vol. 16, 2025, Nr. 1, 335
    DOI (Open Access)
  • Glaser, Selina; Fischer, Anja; Martínez-Manjón, Juan Emilio; López, Cristina; Kretzmer, Helene; Burkhardt, Birgit; Hübschmann, Daniel; Hummel, Michael; Klapper, Wolfram; Kolarova, Julia; Kreuz, Markus; Ott, German; Radlwimmer, Bernhard; Rosolowski, Maciej; Schlesner, Matthias; Rosenwald, Andreas; Stilgenbauer, Stephan; Wagener, Rabea; Zwir, Igor; Trümper, Lorenz; Küppers, Ralf; Lichter, Peter; Ammerpohl, Ole; del Val, Coral; Siebert, Reiner; ICGC MMML-Seq consortium
    Subgrouping germinal center-derived B-cell lymphomas based on machine learning-deduced DNA methylation modules
    In: Leukemia, Vol. 39, 2025, Nr. 4, pp. 967 – 971
    DOI (Open Access)
  • Mountzios, Giannis; Sun, Longhua; Cho, Byoung Chul; Demirci, Umut; Baka, Sofia; Gümüş, Mahmut; Lugini, Antonio; Zhu, Bo; Yu, Yan; Korantzis, Ippokratis; Han, Ji-Youn; Ciuleanu, Tudor-Eliade; Ahn, Myung-Ju; Rocha, Pedro; Mazières, Julien; Lau, Sally C.M.; Schuler, Martin; Blackhall, Fiona; Yoshida, Tatsuya; Owonikoko, Taofeek K.; Paz-Ares, Luis; Jiang, Tony; Hamidi, Ali; Gauto, Diana; Recondo, Gonzalo; Rudin, Charles M.
    Tarlatamab in Small-Cell Lung Cancer after Platinum-Based Chemotherapy
    In: The New England Journal of Medicine, Vol. 393, 2025, Nr. 4, pp. 349 – 361
    DOI
  • Primac, Irina; Tabury, Kevin; Tasdogan, Alpaslan; Baatout, Sarah; Herrmann, Ken
    The molecular blueprint of targeted radionuclide therapy
    In: Nature Reviews Clinical Oncology, Vol. 22, 2025, Nr. 11, pp. 869 – 894
    DOI
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