ZMB Research Program Oncology

ZMB Research Program
Oncology

Oncology

The concept of this research programme is to understand fundamental processes in tumour biology in order to develop novel molecularly defined and rationally applied cancer treatments. Participating researchers from biology, experimental and clinical medicine study tumours as "biological systems" and so called "neo-organs". A large variety of approaches, experimental systems and methodologies are in place to analyse many aspects of tumour development, growth, progression and tumour cell migration.

A first focus lies on the investigation of the behaviour of malignant cells, their signalling interactions, cell death (apoptosis) and proliferation rates, as well as changes in their differentiation programme. Moreover, as most drug targets are proteins, researchers in this programme focus on the molecular analysis of cancer-relevant proteins. Protein function is linked to expression levels, specific subcellular localization, interaction with other proteins and post-translational modifications. These events contribute to the various functional properties that are important for the malignant transformation of cells.

A second focus lies on the investigation of the molecular details of migration and metastasis of tumour cells, as well as cellular responses to cell damage. In addition, in cooperation with researchers from the Program on Immunology and Infectious Diseases, the interactions between the immune system and tumours are of particular interest.

Participating ZMB Members

Prof. Dr.Sebastian Bauer

Group: Translational Sarcoma Research

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Prof. Dr. Dr.Jürgen Becker

Group: Translational Skin Cancer Research

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Prof. Dr. Dr.Sven Brandau

Group:Otorhinolaryngology

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Prof. Dr.Dagmar Führer-Sakel

Director of: Clinic for Endocrinology, Diabetology and Metabolism

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Dr.Barbara M. Grüner

Group: Molecular Tumorpathology

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Prof. Dr.Erich Gulbins

Director of: Department of Molecular Biology

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PD Dr.Iris Helfrich

Group: Vascular Oncology & Metastasis

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Prof. Dr.Ken Herrmann

Group: Clinic for Nuclear Medicine

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Prof. Dr.George Iliakis

Group: Radiation Biology

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Prof. Dr.Verena Jendrossek

Group: Molecular Cell Biology

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Prof. Dr.Diana Klein

Group: Chemical Biology

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Prof. Dr.Shirley Knauer

Group: Molecular Biology II

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Prof. Dr.Ralf Küppers

Group: Molecular Genetics

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Dr.Johann Matschke

Group: Metabolism and Radiation Response

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Prof. Dr.Cläre von Neubeck

Group: Translational Particle Therapy

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Prof. Dr.Annette Paschen

Group: Molecular Tumor Immunology

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Prof. Dr.Tienush Rassaf

Director of: Clinic for Cardiology and Vascular Medicine

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PD Dr.Henning Reis

Group: Onco-Urology

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Prof. Dr.Christian Reinhardt

Director of: Clinic for Hematology and Stem Cell Transplantation

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Prof. Dr.Alexander Roesch

Group: Tumor Heterogeneity & Plasticity

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Prof. Dr.Dirk Schadendorf

Director of: Clinic for Dermatology

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Prof. Dr.Kurt Werner Schmid

Director of: Institute of Neuropathology

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Prof. Dr.Alexander Schramm

Group: Molecular Oncology

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Prof. Dr.Martin Schuler

Director of: Clinic for Internal Medicine (Tumor Research)

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Prof. Dr. Dr.Jens Siveke

Group: Bridge Institute for Experimental Tumor Therapy

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Dr.Silvia Vega-Rubín-de-Celis

Junior Research Group: Autophagy in Cancer

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