ZMB Member Barbara Grünwald

ZMB Member
Barbara Grünwald

Next ZMB-Member
Barbara Grünwald portrait
© B. Grünwald

Prof. Dr. Barbara Grünwald

Department of Urology
West German Cancer Center (WTZ)
University Hospital Essen
Hufelandstraße 55
45122 Essen

Research Overview

The notorious heterogeneity of tumors at the cellular and spatial level is not random noise but a fundamental basis on which solid tumor tissues operate. We therefore envision that a deep understanding of the foundations and consequences of tumor heterogeneity can and should inform clinical practice.
Our group applies a systems biology approach to understand the molecular mechanisms that govern tumor spatial diversity and to provide actionable tools to clinically navigate this phenomenon. Of particular interest to us are the different non-malignant components of solid tumors and how they self-organize to control tumor properties such as growth, invasion, and drug resistance. To this end, we often combine traditional methods such as histopathology with state-of-the-art multimodal profiling techniques, applied to human tissues and patient-derived 3D models. In close collaboration with our partners from the clinic, we strive to further develop our mechanistic insights into tools to effectively navigate tumor heterogeneity during clinical decision making.

Selected Publications

    Journal articles

  • Hörst, Fabian; Rempe, Moritz; Heine, Lukas; Seibold, Constantin; Keyl, Julius; Baldini, Giulia; Ugurel, Selma; Siveke, Jens; Grünwald, Barbara; Egger, Jan; Kleesiek, Jens
    CellViT : Vision Transformers for precise cell segmentation and classification
    In: Medical Image Analysis Vol. 94 (2024) 103143
  • Perera, Sheron; Jang, Gun Ho; Grant, Robert; Notta, Faiyaz; Grünwald, Barbara; Gallinger, Steven; Knox, Jennifer J.; O'Kane, Grainne M.
    hENT1 as a Predictive Biomarker in PDAC-Response
    In: Clinical Cancer Research Vol. 29 (2023) Nr. 15, pp. 2945 - 2948
  • Hidalgo-Sastre, Ana; Brodylo, Roxanne L; Lubeseder-Martellato, Clara; Sipos, Bence; Steiger, Katja; Lee, Marcel; von Figura, Guido; Grünwald, Barbara; Zhong, Suyang; Trajkovic-Arsic, Marija; Neff, Florian; Schmid, Roland M; Siveke, Jens
    Hes1 Controls Exocrine Cell Plasticity and Restricts Development of Pancreatic Ductal Adenocarcinoma in a Mouse Model
    In: The American Journal of Pathology Vol. 186 (2016) Nr. 11, pp. 2934 - 2944