Research Training Group, since 2015:RTG 2098: Biomedicine of the acid sphingomyelinase/acid ceramidase system

Spokesperson: Prof. Dr. Erich Gulbins, University Hospital Essen

Website: http://www.uni-due.de/grk2098

Project		ZMB Member
P01: The role of acid sphingomyelinase (Asm) in T cell responses during tumor development and radiation treatment	More	Prof. Dr. Jan Buer
P02: Sphingolipid signals regulate hypoxia inducible factor 1 in endothelial cells and macrophages after single-dose radiation therapy	More	Prof. Dr. Joachim Fandrey
P04: Role of acid sphingomyelinase in experimental inflammatory bowel disease	More	Prof. Dr. Astrid Westendorf
P06: Role of acid sphingomyelinase in mycobacterial infections	More	Prof. Dr. Karl S. Lang
P07: Preventing infection in cystic fibrosis with acid ceramidase	More	Prof. Dr. Erich Gulbins
P08: Role of ceramide-rich macrodomains in regulating ABC transporters post ischemia	More	Prof. Dr. Dirk Hermann
P10: Sphingosine-1-phosphate (S1P) as a causal factor for impaired function of high-density lipoproteins (HDL) in patients with coronary artery disease (CAD)	More	Prof. Dr. Bodo Levkau

Research Training Group, since 2014:RTG 1949: Immune Response in Infectious Diseases - Regulation between Innate and Adaptive Immunity

Spokesperson: Prof. Dr. Astrid Westendorf, University Hospital Essen

Website: http://www.uni-due.de/grk1949

Project		ZMB Member
Analysis of rapid IFNγ production of NK cells towards adaptive immunity and anti-bacterial activities of macrophages early upon bacterial infection	More	Prof. Dr. Carsten Kirschning
The impact of CD47 signaling on the immune response during influenza virus infection	More	Prof. Dr. Jan Buer
Antigen-independent activation of T cells during polymicrobial sepsis and its impact on the differentiation and function of myeloid cells	More	Prof. Dr. Stefanie Flohè
Impact of different macrophage subsets on T cell responses and pathogen clearance during Plasmodium yoelii infection	More	Prof. Dr. Wiebke Hansen
The role of FXR signaling during infection with persistent prone virus	More	Prof. Dr. Karl Sebastian Lang
Modulation of anti-retroviral T cell responses by different IFNα subtypes	More	Prof. Dr. Ulf Dittmer PD Dr. Kathrin Sutter
Interleukin-33-mediated dysbiosis and the consequences for enteric bacterial infection	More	Prof. Dr. Astrid Westendorf

Research Training Group, since 2012:RTG 1739: Molecular Determinants of the Cellular Radiation Response and their Potential for Response Modulation

Spokesperson: Prof. Dr. Verena Jendrossek, University Hospital Essen

Website: http://www.uni-due.de/med/forschung/grk1739/

Project		ZMB Member
Molecular mechanisms linking repair of DNA double strand breaks by alternative end joining to growth factor signaling R	More	Prof. Dr. George Iliakis
Mechanisms of the p97- and ubiquitin-governed radiation response	More	Prof. Dr. Hemmo Meyer
Functions and regulations of the replication initiation regulator TopBP1 upon exposure to IR	More	Prof. Dr. Dominik Boos
An old passenger as a new driver: Defining Survivin’s role as a link between replication fork dynamics and radiation response	More	Prof. Dr. Shirley Knauer
Role of the protein kinase B/AKT pathway for the cellular radiation response	More	Prof. Dr. Verena Jendrossek
Role of the tyrosine kinase TrkA and TrkB in checkpoint activation and DSB repair	More	Prof. Dr. Alexander Schramm
Identification of novel targets for rational chemoradiotherapy strategies in non-small-cell lung cancer	More	Prof. Dr. Martin Schuler
Role of the acid sphingomyelinase in immune and endothelial cells for anti-tumor effects of irradiation	More	Prof. Dr. Erich Gulbins
Importance of Caveolin-1 for modulating the radiation response in the context of tumor-stroma interactions	More	Prof. Dr. Diana Klein
Identifying and targeting resistance mechanisms to 177Lu-PSMA radioligand therapy of metastatic prostate cancer	More	Prof. Dr. Ken Herrmann

Collaborative Research Center, since 2014:CRC 1093: Supramolecular Chemistry on Proteins

Spokesperson: Prof. Dr. Thomas Schrader, University of Duisburg-Essen

Website: https://www.uni-due.de/crc1093

Project		ZMB Member
Protein-recognition by supramolecular ligands from focused combinatorial libraries (A01)	More	Prof. Dr. Thomas Schrader
Chemical tools from protein class-specific supramolecular ligands (A02)	More	Prof. Dr. Markus Kaiser
Designed copolymers and molecular tweezers for protein surface recognition (A03)	More	Prof. Dr. Thomas Schrader
Ultra-small nanoparticles for protein-specific targeting (A05)	More	Prof. Dr. Matthias Epple
DNA origami nanoarchitectures for predesigned spatial confinement of proteins (A06)	More	Prof. Dr. Barbara Saccà
Computational design of supramolecular ligands for specific tweaking of protein interactions (A07)	More	Prof. Dr. Daniel Hoffmann
Exploring protein-recognition by supramolecular binders with MD and QM/MM methods (A08)	More	Prof. Dr. Elsa Sánchez-García
Raman spectroscopic monitoring of protein recognition by supramolecular ligands (A09)	More	Prof. Dr. Sebastian Schlücker
Supramolecular ligands modulate assembly and function of HtrA proteases (B01)	More	Prof. Dr. Michael Ehrmann
Probing mechanisms of the Cdc48/p97 segregase with supramolecular ligands (B02)	More	Prof. Dr. Hemmo Meyer
Rational targeting of intracellular protein transport signals by supramolecular ligands (B05)	More	Prof. Dr. Shirley Knauer
Targeting centromere recruitment of mitotic regulators by supramolecular ligands (B06)	More	Prof. Dr. Andrea Musacchio
Manipulation of the kinetochore-microtubule interface by supramolecular ligands (B07)	More	Prof. Dr. Stefan Westermann
NMR Spectroscopy (Z03)	More	Prof. Dr. Peter Bayer