CRC 1430 Welcome
Welcome to the Collaborative Research Centre "Molecular Mechanisms on Cell State Transitions" (CRC 1430). The CRC 1430 brings together scientist of the Center of Medical Biotechnology at the University of Duisburg-Essen, the Max Planck Institute of Molecular Physiology and the Universities of Dortmund, Münster, Cologne and Frankfurt.
About
The DFG-funded CRC 1430 "Molecular Mechanisms of Cell State Transitions" explores fundamental molecular mechanisms that underlie the regulation of cell proliferation. Cell proliferation needs to be tightly controlled to ensure organismal development and tissue regeneration, while preventing neoplastic disorders. A key hallmark of this control is the establishment of distinct, biochemically or epigenetically defined cell states and the regulated transitions between these states.

These transitions govern cell cycle progression and underlie cancer cell plasticity and cancer therapy resistance. The research focus is on understanding the switch-like molecular trigger mechanisms of state transitions and develop means to modulate them, ultimately to identify novel therapeutic strategies. Specifically, to overcome current limitations, the CRC 1430 will develop and apply direct methodologies such as advanced biochemical reconstitution and novel approaches of acute chemical or optical perturbation to decipher how the key triggers sense, integrate and transmit signals to regulatory circuits that define cell states.
EVENTS

Upcoming CRC 1430 Retreat 2023
Save the date for our upcoming
CRC 1430 Retreat, that will take place from
June 5 - 7, 2023.
Location: Hotel Mutterhaus (Düsseldorf)
More information regarding registration and program will follow asap.

Upcoming 1st International Symposium of CRC 1430: „Triggers of cell state transitions“
Save the date for our upcoming
1st International CRC1430 Symposium
„Triggers of cell state transitions“
from October 10 - 12, 2023.
Location: Glaspavillon, University Duisburg-Essen, Campus Essen
***
Confirmed Speakers:
***
Martin Eilers (University Wuerzburg)
Alessio Ciulli (University of Dundee)
Helle Ulrich (IMB Mainz)
Stefan Knapp (GU Frankfurt)
Tom Muir (Princeton)
Dana Branzei (IFOM Milan, Italy)
Ruth Scherz-Shouval (Weizmann Institute of Science Rehovot)
Anne Bertolotti (MRC Laboratory of Molecular Biology, Cambridge)
Thomas Langer (MPI Biology for Ageing, Cologne)
Tobias Meyer (Weill Cornell Medicine, NYC)
Elke Deuerling (University of Konstanz)
Johannes Walter (Harvard University)
Andrea Musacchio (MPI Dortmund)

Upcoming CRC 1430 Guest Lectures
Upcoming Guest Lectures:
20.06.2023
Jan Riemer
(University of Cologne)
11.07.2023
Renata Basto
(Institute Curie, Paris )
07.11.2023
Gertrudis Rojas
(Center of Molecular Immunology, Havana)
05.12.2023
Patrizia Agostinis
(VIB-Center for Cancer Biology, Leuven)

- Basic introduction to to Research Data Management
June 21, 2023 (9 a.m. - 4 p.m.)
Bibliothekssaal - Navigating Academic Careers - Influence and Empowerment for female Scientists
August 28-29, 2023
Tanja Hentschel (Amsterdam Business School) - Story Telling Techniques for Scientific Presentations
November 16, 2023
Guido Molina
NEWS

Project A02 Verena Cmentowski wins poster prize
Verena Cmentowski, doctoral researcher in the lab of Andrea Musacchio at the Max Planck Institute of Molecular Physiology in Dortmund, was awarded one of the three poster prizes at the IMPRS-LM Student Symposium 2023 "Building Blocks of Life”, taking place 10th to 12th May 2023. Congrats, Verena!

Deutsche Krebspreis 2023 Christian Reinhardt ausgezeichnet
[31.03.2023] Der Deutsche Krebspreis 2023 in der Kategorie „Experimentelle Forschung“ geht an Prof. Dr. Christian Reinhardt, Forscher an der Medizinischen Fakultät der UDE. Sein Forschungsschwerpunkt liegt in den Bereichen der Genomstabilität und der Biologie von aggressiven Lymphomen auch „Lymphdrüsenkrebs“ genannt. Professor Reinhardt ist Direktor der Klinik für Hämatologie und Stammzelltransplantation des Universitätsklinikums Essen.

Aspire Afternoon 2022 Exzellente Forschung? - Mit gerechten Chancen!
Was macht exzellente Forschung aus, wie ist Exzellenz eigentlich definiert und in welchem Verhältnis stehen Exzellenz und Chancengerechtigkeit zueinander?
Diese und weitere Fragen untersucht Prof. Dr. Ute Klammer und ihr Team im aktuellen BMBF-Projekt „EXENKO“. Dieses Forschungs- und Praxisprojekt des Instituts für Soziologie (IfS) und des Essener Kollegs für Geschlechterforschung (EKfG) stand im Mittelpunkt des ASPIRE Afternoon 2022, zu dem die Sonderforschungsbereiche SFB 1093 und SFB 1430 der Chemie, Biologie und Medizin am 23.11.2022 eingeladen haben.
Key Note Lecture von Prof. Dr. Ute Klammer:
"Exzellenz und Chancengerechtigkeit: Antagonisten oder vereinbare Konzepte?"
Der Vortrag ist nachträglich abrufbar: Zur Vortragsaufzeichnung
Publications
-
Clp-targeting BacPROTACs impair mycobacterial proteostasis and survivalIn: Cell Vol. 23 (2023) in pressISSN: 0092-8674; 1097-4172Online Full Text: dx.doi.org/ (Open Access)
-
HLA class II loss and JAK1/2 deficiency coevolve in melanoma leading to CD4 T cell and IFNγ cross-resistanceIn: Clinical Cancer Research (2023) in pressISSN: 1557-3265; 1078-0432Online Full Text: dx.doi.org/
-
Systematic analysis of microtubule plus-end networks defines EB-cargo complexes critical for mitosis in budding yeastIn: Molecular Biology of the Cell Vol. 34 (2023) Nr. 5,ISSN: 1059-1524; 1939-4586; 1044-2030Online Full Text: dx.doi.org/ Online Full Text (Open Access)
-
Targeting of client proteins to the VCP/p97/Cdc48 unfolding machineIn: Frontiers in Molecular Biosciences Vol. 10 (2023)ISSN: 2296-889XOnline Full Text: dx.doi.org/ (Open Access)
-
Toward effective Atg8-based ATTECs : Approaches and perspectivesIn: Journal of Cellular Biochemistry (2023) in pressISSN: 1097-4644; 0730-2312Online Full Text: dx.doi.org/ (Open Access)
-
A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing ProteinsIn: Frontiers in Cell and Developmental Biology Vol. 10 (2022)ISSN: 2296-634XOnline Full Text: dx.doi.org/ (Open Access)
-
ABP-Finder : A Tool to Identify Antibacterial Peptides and the Gram-Staining Type of Targeted BacteriaIn: Antibiotics Vol. 11 (2022) Nr. 12,ISSN: 2079-6382Online Full Text: dx.doi.org/ (Open Access)
-
An allosteric HTRA1-calpain 2 complex with restricted activation profileIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 119 (2022) Nr. 14,ISSN: 1091-6490; 0027-8424Online Full Text: dx.doi.org/ Online Full Text (Open Access)
-
Chemoproteomics‐Enabled Identification of 4‐Oxo‐β‐Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9In: Angewandte Chemie International Edition Vol. 61 (2022) Nr. 47, pp. e202210498ISSN: 1521-3773; 1433-7851; 0570-0833Online Full Text: dx.doi.org/ (Open Access)
-
Dimerization of the Peptide CXCR4-Antagonist on Macromolecular and Supramolecular Protraction Arms Affords Increased Potency and Enhanced Plasma StabilityIn: Bioconjugate Chemistry Vol. 33 (2022) Nr. 4, pp. 594 - 607ISSN: 1043-1802; 1520-4812Online Full Text: dx.doi.org/
-
Distinct genetically-determined origins of Myd88/Bcl2-driven aggressive lymphoma rationalize targeted therapeutic intervention strategiesIn: Blood Cancer Discovery (2022) in pressISSN: 2643-3230; 2643-3249Online Full Text: dx.doi.org/ (Open Access)
-
Functions and Interactions of Mammalian KDM5 DemethylasesIn: Frontiers in Genetics Vol. 13 (2022)ISSN: 1664-8021Online Full Text: dx.doi.org/ (Open Access)
-
Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicityIn: Journal for ImmunoTherapy of Cancer Vol. 10 (2022) Nr. 6,ISSN: 2051-1426Online Full Text: dx.doi.org/ (Open Access)
-
MCU controls melanoma progression through a redox-controlled phenotype switchIn: EMBO Reports Vol. 23 (2022) Nr. 11,ISSN: 1469-3178; 1469-221XOnline Full Text: dx.doi.org/ (Open Access)
-
Novel, highly potent PROTACs targeting AURORA-A kinaseIn: Current Research in Chemical Biology Vol. 2 (2022)ISSN: 2666-2469Online Full Text: dx.doi.org/ (Open Access)
-
On the role of phase separation in the biogenesis of membraneless compartmentsIn: The EMBO Journal Vol. 41 (2022) Nr. 5,ISSN: 0261-4189; 1460-2075Online Full Text: dx.doi.org/ (Open Access)
-
PPI-Affinity : A Web Tool for the Prediction and Optimization of Protein-Peptide and Protein-Protein Binding AffinityIn: Journal of Proteome Research Vol. 21 (2022) Nr. 8, pp. 1829 - 1841ISSN: 1535-3907; 1535-3893Online Full Text: dx.doi.org/ (Open Access)
-
PROTAC degraders as chemical probes for studying target biology and target validationIn: Chemical Society Reviews Vol. 51 (2022) Nr. 18, pp. 7971 - 7993ISSN: 1460-4744; 0306-0012Online Full Text: dx.doi.org/
-
Persister state-directed transitioning and vulnerability in melanomaIn: Nature Communications Vol. 13 (2022) Nr. 1,ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access)
-
Structural basis for specific inhibition of the deubiquitinase UCHL1In: Nature Communications Vol. 13 (2022) Nr. 1,ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access)
-
Structure of the RZZ complex and molecular basis of Spindly‐driven corona assembly at human kinetochoresIn: The EMBO Journal (2022)ISSN: 0261-4189; 1460-2075Online Full Text: dx.doi.org/ Online Full Text (Open Access)
-
Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1In: Molecular Cell Vol. 82 (2022) Nr. 14, pp. 2633 - 2649.e7ISSN: 1097-2765; 1097-4164Online Full Text: dx.doi.org/
-
Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTNIn: The Journal of Biological Chemistry (JBC) Vol. 298 (2022) Nr. 6,ISSN: 0021-9258; 1083-351XOnline Full Text: dx.doi.org/ (Open Access)
-
Cdc4 phospho-degrons allow differential regulation of ame1ceⁿp⁻u protein stability across the cell cycleIn: eLife Vol. 10 (2021)ISSN: 2050-084XOnline Full Text: dx.doi.org/ (Open Access)
-
Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochoreIn: The EMBO Journal Vol. 40 (2021) Nr. 18,ISSN: 0261-4189; 1460-2075Online Full Text: dx.doi.org/ (Open Access)
-
Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasisIn: Cell Reports Vol. 37 (2021) Nr. 8,ISSN: 2211-1247Online Full Text: dx.doi.org/ Online Full Text (Open Access)
-
TopBP1 utilises a bipartite GINS binding mode to activate the replicative helicase(2023)Online Full Text: dx.doi.org/ (Open Access)
-
Conformational transitions of the mitotic adaptor Spindly underlie its interaction with Dynein and Dynactin(2022)Online Full Text: dx.doi.org/ Online Full Text (Open Access)
-
Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate(2022)Online Full Text: dx.doi.org/ (Open Access)
-
Targeted Protein Unfolding at the Golgi ApparatusIn: Golgi: Methods and Protocols / Wang, Yanzhuang; Lupashin, Vladimir V.; Graham, Todd R. (Eds.) 2022, pp. 645 - 659ISBN: 978-1-0716-2639-9; 978-1-0716-2638-2Online Full Text: dx.doi.org/
Journal articles
Articles
Book articles / Proceedings papers
Partner




