CRC 1430 Welcome
Welcome to the Collaborative Research Centre "Molecular Mechanisms on Cell State Transitions" (CRC 1430). The CRC 1430 brings together scientist of the Center of Medical Biotechnology at the University of Duisburg-Essen, the Max Planck Institute of Molecular Physiology and the Universities of Dortmund, Münster, Cologne and Frankfurt.
The DFG-funded CRC 1430 "Molecular Mechanisms of Cell State Transitions" explores fundamental molecular mechanisms that underlie the regulation of cell proliferation. Cell proliferation needs to be tightly controlled to ensure organismal development and tissue regeneration, while preventing neoplastic disorders. A key hallmark of this control is the establishment of distinct, biochemically or epigenetically defined cell states and the regulated transitions between these states.
These transitions govern cell cycle progression and underlie cancer cell plasticity and cancer therapy resistance. The research focus is on understanding the switch-like molecular trigger mechanisms of state transitions and develop means to modulate them, ultimately to identify novel therapeutic strategies. Specifically, to overcome current limitations, the CRC 1430 will develop and apply direct methodologies such as advanced biochemical reconstitution and novel approaches of acute chemical or optical perturbation to decipher how the key triggers sense, integrate and transmit signals to regulatory circuits that define cell states.
Story Telling Techniques for Scientific Presentations
November 16, 2023
Introduction to R
November 29-30, 2023
INF & RDS
We thank all speakers and participants for contributing to the success of our 1st International Symposium Triggers of Cell State Transitions!
Location: Glaspavillon, University Duisburg-Essen, Campus Essen
New Associated PI Katarzyna Kliza joins the CRC1430
The CRC1430 is pleased to welcome Dr. Katarzyna Kliza as an associated principal investigator. Katarzyna is a Research Group Leader at the MPI of Molecular Physiology, where she is engaged in studying the Decoding of Post-Translational Modification Signalling Networks, with a specific focus on ADP-ribosylation. Her research involves a multifaceted and interdisciplinary approach, incorporating proteomics, biochemistry, molecular, and cell biology techniques.
We´re looking forward to future collaborations!
There is a new paper published in the newest Volume of Nature Communications by the Gatsogiannis Lab. Pex1/Pex6 is a heterohexamer which is necessary for peroxisomal receptor recycling and peroxisome formation. In the paper the group reveals the mechanisms how the heterohexamer coordinates to achieve substrate translocation.Therefore, they report their cryoEM structures of Pex1/Pex6 with a substrate protein trapped in the central pore of the heterohexameric AAA+-ATPase.
September 22, 2023 PhD Fellowship for Eda Şamiloğlu Tengirşek
Congratulations to Eda Şamiloğlu Tengirşek from the Gatsogiannis Lab (A04) for receiving the PhD Fellowship by the "Studienstiftung des deutschen Volkes"! We are proud to see that our short-term fellowships offer such opportunities for our PhD Students.
September 19-21, 2023 The ICCE Practical Training Course
From 19th to 21st of September the Practical Training Course "Acute manipulation and sensor-based readout of dynamic cell behaviour and cell state transitions using advanced light microscopy techniques" offered by the ICCE took place. The participants got to know new methods and insights to advance their research.
September 18, 2023 A new super resolution microscope is available at the Imaging Center Campus Essen (ICCE)!
The highly complex, multimodal high-speed Structured Illumination Microscope (SIM) for live-cell imaging can be used by our CRC 1430 researchers to decipher important dynamic cellular processes and cell state transitions with very high spatial and temporal precision. In addition to the versatility of different imaging modalities such as multicolor 3D-SIM, 2D-SIM, TIRF-SIM and TIRF and their flexible combinations, the system allows acute light-induced manipulations and the observation of the effects on cellular activities in real time.
The Microscope was obtained through DFG funding (Major Research Instrumentation Programme as per Art. 91b GG, INST 20876/294-1 FUGG) to Prof. Perihan Nalbant and Co-Applicants.