Welcome to the Collaborative Research Centre "Molecular Mechanisms of Cell State Transitions" (CRC 1430)
The DFG-funded CRC 1430 "Molecular Mechanisms of Cell State Transitions" explores fundamental molecular mechanisms that underlie the regulation of cell proliferation. Cell proliferation needs to be tightly controlled to ensure organismal development and tissue regeneration, while preventing neoplastic disorders. A key hallmark of this control is the establishment of distinct, biochemically or epigenetically defined cell states and the regulated transitions between these states.
These transitions govern cell cycle progression and underlie cancer cell plasticity and cancer therapy resistance. The research focus is on understanding the switch-like molecular trigger mechanisms of state transitions and develop means to modulate them, ultimately to identify novel therapeutic strategies. Specifically, to overcome current limitations, the CRC 1430 will develop and apply direct methodologies such as advanced biochemical reconstitution and novel approaches of acute chemical or optical perturbation to decipher how the key triggers sense, integrate and transmit signals to regulatory circuits that define cell states.
Upcoming CRC 1430 Guest Lectures
DOLCE (Dortmund Life Science Center), TU Dortmund
Institute of Cell Biology and Immunology, University of Stuttgart
|Silvia Vega Rubin de Celis
Institut für Zellbiologie (Tumorforschung), UKE
Center for Molecular Medicine, Austrian Academy of Sciences
A list of previous speakers can be found here:
Two new papers on cell migration were published by Prof. Dr. Perihan Nalbant (MB) in cooperation with Dr. Leif Dehmelt (Chemistry and Chemical Biology, TU Dortmund).
For efficient cell migration dynamic cell shape changes need to be coordinated. Most cell types form protrusions in the front and a retracting tail. In these two papers the groups used TIRF microscopy and translocation sensors to measure Rho GTPase activity which play a key role in the spatio-temporal coordination of the relevant cytoskeletal dynamics.
We thank all speakers and participants for contributing to the success of our 1st International Symposium Triggers of Cell State Transitions!
Location: Glaspavillon, University Duisburg-Essen, Campus Essen
New Associated PI Katarzyna Kliza joins the CRC1430
The CRC1430 is pleased to welcome Dr. Katarzyna Kliza as an associated principal investigator. Katarzyna is a Research Group Leader at the MPI of Molecular Physiology, where she is engaged in studying the Decoding of Post-Translational Modification Signalling Networks, with a specific focus on ADP-ribosylation. Her research involves a multifaceted and interdisciplinary approach, incorporating proteomics, biochemistry, molecular, and cell biology techniques.
We´re looking forward to future collaborations!