CRC 1430 Welcome

Welcome to the Collaborative Research Centre "Molecular Mechanisms on Cell State Transitions" (CRC 1430). The CRC 1430 brings together scientist of the Center of Medical Biotechnology at the University of Duisburg-Essen, the Max Planck Institute of Molecular Physiology and the Universities of Dortmund, Münster, Cologne and Frankfurt.

About

The DFG-funded CRC 1430 "Molecular Mechanisms of Cell State Transitions" explores fundamental molecular mechanisms that underlie the regulation of cell proliferation. Cell proliferation needs to be tightly controlled to ensure organismal development and tissue regeneration, while preventing neoplastic disorders. A key hallmark of this control is the establishment of distinct, biochemically or epigenetically defined cell states and the regulated transitions between these states.

These transitions govern cell cycle progression and underlie cancer cell plasticity and cancer therapy resistance. The research focus is on understanding the switch-like molecular trigger mechanisms of state transitions and develop means to modulate them, ultimately to identify novel therapeutic strategies. Specifically, to overcome current limitations, the CRC 1430 will develop and apply direct methodologies such as advanced biochemical reconstitution and novel approaches of acute chemical or optical perturbation to decipher how the key triggers sense, integrate and transmit signals to regulatory circuits that define cell states.

EVENTS

© CRC1430

Upcoming CRC 1430 Retreat 2023

Save the date for our upcoming

CRC 1430 Retreat, that will take place from

June 5 - 7, 2023.

Location: Hotel Mutterhaus (Düsseldorf)


More information regarding registration and program will follow asap.

© UDE

Upcoming 1st International Symposium of CRC 1430: „Triggers of cell state transitions“

Save the date for our upcoming

1st International CRC1430 Symposium
„Triggers of cell state transitions“

from October 10 - 12, 2023.

Location: Glaspavillon, University Duisburg-Essen, Campus Essen

***
Confirmed Speakers:
***

Martin Eilers (University Wuerzburg)

Alessio Ciulli (University of Dundee)

Helle Ulrich (IMB Mainz)

Stefan Knapp (GU Frankfurt)

Tom Muir (Princeton)

Dana Branzei (IFOM Milan, Italy)

Ruth Scherz-Shouval (Weizmann Institute of Science Rehovot)

Anne Bertolotti (MRC Laboratory of Molecular Biology, Cambridge)

Thomas Langer (MPI Biology for Ageing, Cologne)

Tobias Meyer (Weill Cornell Medicine, NYC)

Elke Deuerling (University of Konstanz)

Johannes Walter (Harvard University)

Andrea Musacchio (MPI Dortmund)

Upcoming CRC 1430 Guest Lectures

Upcoming Guest Lectures:

20.06.2023
Jan Riemer
(University of Cologne)

11.07.2023
Renata Basto
(Institute Curie, Paris )  

07.11.2023
Gertrudis Rojas
(Center of Molecular Immunology, Havana)

05.12.2023
Patrizia Agostinis
(VIB-Center for Cancer Biology, Leuven)

© pixabay
  1. Basic introduction to to Research Data Management
    June 21, 2023 (9 a.m. - 4 p.m.)
    Bibliothekssaal
  2. Navigating Academic Careers - Influence and Empowerment for female Scientists
    August 28-29, 2023
    Tanja Hentschel (Amsterdam Business School)
  3. Story Telling Techniques for Scientific Presentations
    November 16, 2023
    Guido Molina

NEWS

© MPI/Cmentowski

Project A02 Verena Cmentowski wins poster prize

Verena Cmentowski, doctoral researcher in the lab of Andrea Musacchio at the Max Planck Institute of Molecular Physiology in Dortmund, was awarded one of the three poster prizes at the IMPRS-LM Student Symposium 2023 "Building Blocks of Life”, taking place 10th to 12th May 2023. Congrats, Verena!

 

Project A02
© UME

Deutsche Krebspreis 2023 Christian Reinhardt ausgezeichnet

[31.03.2023] Der Deutsche Krebspreis 2023 in der Kategorie „Experimentelle Forschung“ geht an Prof. Dr. Christian Reinhardt, Forscher an der Medizinischen Fakultät der UDE. Sein Forschungsschwerpunkt liegt in den Bereichen der Genomstabilität und der Biologie von aggressiven Lymphomen auch „Lymphdrüsenkrebs“ genannt. Professor Reinhardt ist Direktor der Klinik für Hämatologie und Stammzelltransplantation des Universitätsklinikums Essen.

Read more
© CRC1093

Aspire Afternoon 2022 Exzellente Forschung? - Mit gerechten Chancen!

Was macht exzellente Forschung aus, wie ist Exzellenz eigentlich definiert und in welchem Verhältnis stehen Exzellenz und Chancengerechtigkeit zueinander?

Diese und weitere Fragen untersucht Prof. Dr. Ute Klammer und ihr Team im aktuellen BMBF-Projekt „EXENKO“. Dieses Forschungs- und Praxisprojekt des Instituts für Soziologie (IfS) und des Essener Kollegs für Geschlechterforschung (EKfG) stand im Mittelpunkt des ASPIRE Afternoon 2022, zu dem die Sonderforschungsbereiche SFB 1093 und SFB 1430 der Chemie, Biologie und Medizin am 23.11.2022 eingeladen haben.

Key Note Lecture von Prof. Dr. Ute Klammer:

"Exzellenz und Chancengerechtigkeit: Antagonisten oder vereinbare Konzepte?"

Der Vortrag ist nachträglich abrufbar: Zur Vortragsaufzeichnung

Publications

    Journal articles

  • Hoi, David M.; Junker, Sabryna; Junk, Lukas; Schwechel, Kristin; Fischel, Katharina; Podlesainski, David; Hawkins, Paige M.E.; van Geelen, Lasse; Kaschani, Farnusch; Leodolter, Julia; Morreale, Francesca Ester; Kleine, Stefan; Guha, Somraj; Rumpel, Klaus; Schmiedel, Volker M.; Weinstabl, Harald; Meinhart, Anton; Payne, Richard J.; Kaiser, Markus; Hartl, Markus; Boehmelt, Guido; Kazmaier, Uli; Kalscheuer, Rainer; Clausen, Tim
    Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival
    In: Cell Vol. 23 (2023) in press
    ISSN: 0092-8674; 1097-4172
    Online Full Text: dx.doi.org/ (Open Access)
  • Stupia, Simone; Heeke, Christina; Brüggemann, Alicia; Zaremba-Montenari, Anne; Thier, Beatrice; Kretz, Julia; Sucker, Antje; Philip, Manuel; Zelinskyy, Gennadiy; Ferrone, Soldano; Rösch, Alexander; Horn, Susanne; Hadaschik, Eva; Schadendorf, Dirk; Trilling, Mirko; Dittmer, Ulf; Griewank, Klaus; Zhao, Fang; Paschen, Annette
    HLA class II loss and JAK1/2 deficiency coevolve in melanoma leading to CD4 T cell and IFNγ cross-resistance
    In: Clinical Cancer Research (2023) in press
    ISSN: 1557-3265; 1078-0432
    Online Full Text: dx.doi.org/
  • Kornakov, Nikolay; Westermann, Stefan
    Systematic analysis of microtubule plus-end networks defines EB-cargo complexes critical for mitosis in budding yeast
    In: Molecular Biology of the Cell Vol. 34 (2023) Nr. 5,
    ISSN: 1059-1524; 1939-4586; 1044-2030
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Meyer, Hemmo; van den Boom, Johannes
    Targeting of client proteins to the VCP/p97/Cdc48 unfolding machine
    In: Frontiers in Molecular Biosciences Vol. 10 (2023)
    ISSN: 2296-889X
    Online Full Text: dx.doi.org/ (Open Access)
  • Schwalm, Martin P.; Knapp, Stefan; Rogov, Vladimir V.
    Toward effective Atg8-based ATTECs : Approaches and perspectives
    In: Journal of Cellular Biochemistry (2023) in press
    ISSN: 1097-4644; 0730-2312
    Online Full Text: dx.doi.org/ (Open Access)
  • Schwalm, Martin P.; Berger, Lena M.; Meuter, Maximilian N.; Vasta, James D.; Corona, Cesear R.; Röhm, Sandra; Berger, Benedict-Tilman; Farges, Frederic; Beinert, Sebastian M.; Preuss, Franziska; Morasch, Viktoria; Rogov, Vladimir V.; Mathea, Sebastian; Saxena, Krishna; Robers, Matthew B.; Müller, Susanne; Knapp, Stefan
    A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins
    In: Frontiers in Cell and Developmental Biology Vol. 10 (2022)
    ISSN: 2296-634X
    Online Full Text: dx.doi.org/ (Open Access)
  • Ruiz-Blanco, Yasser B.; Agüero-Chapin, Guillermin; Romero-Molina, Sandra; Antunes, Agostinho; Olari, Lia-Raluca; Spellerberg, Barbara; Münch, Jan; Sanchez-Garcia, Elsa
    ABP-Finder : A Tool to Identify Antibacterial Peptides and the Gram-Staining Type of Targeted Bacteria
    In: Antibiotics Vol. 11 (2022) Nr. 12,
    ISSN: 2079-6382
    Online Full Text: dx.doi.org/ (Open Access)
  • Rey, Juliana; Breiden, Maike; Lux, Vanda; Bluemke, Anika; Steindel, Maike; Ripkens, Kamilla; Möllers, Bastian; Bravo Rodriguez, Kenny; Boisguerin, Prisca; Volkmer, Rudolf; Mieres-Perez, Joel; Clausen, Tim; Sánchez-García, Elsa; Ehrmann, Michael
    An allosteric HTRA1-calpain 2 complex with restricted activation profile
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 119 (2022) Nr. 14,
    ISSN: 1091-6490; 0027-8424
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Carvalho, Luís A. R.; Ross, Breyan; Fehr, Lorenz; Bolgi, Oguz; Wöhrle, Svenja; Lum, Kenneth M.; Podlesainski, David; Vieira, Andreia C.; Kiefersauer, Reiner; Félix, Rita; Rodrigues, Tiago; Lucas, Susana D.; Groß, Olaf; Geiss‐Friedlander, Ruth; Cravatt, Benjamin F.; Huber, Robert; Kaiser, Markus; Moreira, Rui
    Chemoproteomics‐Enabled Identification of 4‐Oxo‐β‐Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9
    In: Angewandte Chemie International Edition Vol. 61 (2022) Nr. 47, pp. e202210498
    ISSN: 1521-3773; 1433-7851; 0570-0833
    Online Full Text: dx.doi.org/ (Open Access)
  • Harms, Mirja; Hansson, Rikke Fabech; Carmali, Sheiliza; Almeida-Hernández, Yasser; Sanchez-Garcia, Elsa; Münch, Jan; Zelikin, Alexander N.
    Dimerization of the Peptide CXCR4-Antagonist on Macromolecular and Supramolecular Protraction Arms Affords Increased Potency and Enhanced Plasma Stability
    In: Bioconjugate Chemistry Vol. 33 (2022) Nr. 4, pp. 594 - 607
    ISSN: 1043-1802; 1520-4812
    Online Full Text: dx.doi.org/
  • Flumann, Ruth; Hansen, Julia; Pelzer, Benedikt W.; Nieper, Pascal; Lohmann, Tim; Kisis, Ilmars; Riet, Tobias; Kohlhas, Viktoria; Nguyen, Phuong-Hien; Peifer, Martin; Abedpour, Nima; Bosco, Graziella; Thomas, Roman K.; Kochanek, Moritz; Knufer, Jacqueline; Jonigkeit, Lorenz; Beleggia, Filippo; Holzem, Alessandra; Buttner, Reinhard; Lohneis, Philipp; Meinel, Jorn; Ortmann, Monika; Persigehl, Thorsten; Hallek, Michael; Calado, Dinis Pedro.; Chmielewski, Markus; Klein, Sebastian; Gothert, Joachim R.; Chapuy, Bjoern; Zevnik, Branko; Wunderlich, F. Thomas; von Tresckow, Bastian; Jachimowicz, Ron D.; Melnick, Ari M.; Reinhardt, Christian; Knittel, Gero
    Distinct genetically-determined origins of Myd88/Bcl2-driven aggressive lymphoma rationalize targeted therapeutic intervention strategies
    In: Blood Cancer Discovery (2022) in press
    ISSN: 2643-3230; 2643-3249
    Online Full Text: dx.doi.org/ (Open Access)
  • Pavlenko, Egor; Ruengeler, Till; Engel, Paulina; Poepsel, Simon
    Functions and Interactions of Mammalian KDM5 Demethylases
    In: Frontiers in Genetics Vol. 13 (2022)
    ISSN: 1664-8021
    Online Full Text: dx.doi.org/ (Open Access)
  • Thier, Beatrice; Zhao, Fang; Stupia, Simone; Brüggemann, Alicia; Koch, Johannes; Schulze, Nina; Horn, Susanne; Coch, Christoph; Hartmann, Gunther; Sucker, Antje; Schadendorf, Dirk; Paschen, Annette
    Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicity
    In: Journal for ImmunoTherapy of Cancer Vol. 10 (2022) Nr. 6,
    ISSN: 2051-1426
    Online Full Text: dx.doi.org/ (Open Access)
  • Stejerean-Todoran, Ioana; Zimmermann, Katharina; Gibhardt, Christine S; Vultur, Adina; Ickes, Christian; Shannan, Batool; Bonilla del Rio, Zuriñe; Wölling, Anna; Cappello, Sabrina; Sung, Hsu-Min; Shumanska, Magdalena; Zhang, Xin; Nanadikar, Maithily; Latif, Muhammad U; Wittek, Anna; Lange, Felix; Waters, Andrea; Brafford, Patricia; Wilting, Jörg; Urlaub, Henning; Katschinski, Dörthe M; Rehling, Peter; Lenz, Christof; Jakobs, Stefan; Ellenrieder, Volker; Rösch, Alexander; Schön, Michael P; Herlyn, Meenhard; Stanisz, Hedwig; Bogeski, Ivan
    MCU controls melanoma progression through a redox-controlled phenotype switch
    In: EMBO Reports Vol. 23 (2022) Nr. 11,
    ISSN: 1469-3178; 1469-221X
    Online Full Text: dx.doi.org/ (Open Access)
  • Bozilovic, Jelena; Eing, Lorenz; Berger, Benedict-Tilman; Adhikari, Bikash; Weckesser, Janik; Berner, Nicola B.; Wilhelm, Stephanie; Kuster, Bernhard; Wolf, Elmar; Knapp, Stefan
    Novel, highly potent PROTACs targeting AURORA-A kinase
    In: Current Research in Chemical Biology Vol. 2 (2022)
    ISSN: 2666-2469
    Online Full Text: dx.doi.org/ (Open Access)
  • Musacchio, Andrea
    On the role of phase separation in the biogenesis of membraneless compartments
    In: The EMBO Journal Vol. 41 (2022) Nr. 5,
    ISSN: 0261-4189; 1460-2075
    Online Full Text: dx.doi.org/ (Open Access)
  • Romero-Molina, Sandra; Ruiz-Blanco, Yasser B.; Mieres-Perez, Joel; Harms, Mirja; Münch, Jan; Ehrmann, Michael; Sanchez-Garcia, Elsa
    PPI-Affinity : A Web Tool for the Prediction and Optimization of Protein-Peptide and Protein-Protein Binding Affinity
    In: Journal of Proteome Research Vol. 21 (2022) Nr. 8, pp. 1829 - 1841
    ISSN: 1535-3907; 1535-3893
    Online Full Text: dx.doi.org/ (Open Access)
  • Němec, Václav; Schwalm, Martin P.; Müller, Susanne; Knapp, Stefan
    PROTAC degraders as chemical probes for studying target biology and target validation
    In: Chemical Society Reviews Vol. 51 (2022) Nr. 18, pp. 7971 - 7993
    ISSN: 1460-4744; 0306-0012
    Online Full Text: dx.doi.org/
  • Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Jürgen; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodríguez-López, José Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Rösch, Alexander
    Persister state-directed transitioning and vulnerability in melanoma
    In: Nature Communications Vol. 13 (2022) Nr. 1,
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Grethe, Christian; Schmidt, Mirko; Kipka, Gian-Marvin; O’Dea, Rachel; Gallant, Kai; Janning, Petra; Gersch, Malte
    Structural basis for specific inhibition of the deubiquitinase UCHL1
    In: Nature Communications Vol. 13 (2022) Nr. 1,
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Raisch, Tobias; Ciossani, Giuseppe; d’Amico, Ennio; Cmentowski, Verena; Carmignani, Sara; Maffini, Stefano; Merino, Felipe; Wohlgemuth, Sabine; Vetter, Ingrid R.; Raunser, Stefan; Musacchio, Andrea
    Structure of the RZZ complex and molecular basis of Spindly‐driven corona assembly at human kinetochores
    In: The EMBO Journal (2022)
    ISSN: 0261-4189; 1460-2075
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Kravić, Bojana; Bionda, Tihana; Siebert, Alexander; Gahlot, Pinki; Levantovsky, Sophie; Behrends, Christian; Meyer, Hemmo
    Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1
    In: Molecular Cell Vol. 82 (2022) Nr. 14, pp. 2633 - 2649.e7
    ISSN: 1097-2765; 1097-4164
    Online Full Text: dx.doi.org/
  • Kröning, Alexander; van den Boom, Johannes; Kracht, Matthias; Kück, Anja; Meyer, Hemmo
    Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTN
    In: The Journal of Biological Chemistry (JBC) Vol. 298 (2022) Nr. 6,
    ISSN: 0021-9258; 1083-351X
    Online Full Text: dx.doi.org/ (Open Access)
  • Böhm, Miriam; Killinger, Kerstin; Dudziak, Alexander; Pant, Pradeep; Jänen, Karolin; Hohoff, Simone; Mechtler, Karl; Örd, Mihkel; Loog, Mart; Sánchez-García, Elsa; Westermann, Stefan
    Cdc4 phospho-degrons allow differential regulation of ame1ceⁿp⁻u protein stability across the cell cycle
    In: eLife Vol. 10 (2021)
    ISSN: 2050-084X
    Online Full Text: dx.doi.org/ (Open Access)
  • Dudziak, Alexander; Engelhard, Lena; Bourque, Cole; Klink, Björn Udo; Rombaut, Pascaline; Kornakov, Nikolay; Jänen, Karolin; Herzog, Franz; Gatsogiannis, Christos; Westermann, Stefan
    Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochore
    In: The EMBO Journal Vol. 40 (2021) Nr. 18,
    ISSN: 0261-4189; 1460-2075
    Online Full Text: dx.doi.org/ (Open Access)
  • Dorsch, Madeleine; Kowalczyk, Manuela; Planque, Mélanie; Heilmann, Geronimo; Urban, Sebastian; Dujardin, Philip; Forster, Jan; Ueffing, Kristina; Nothdurft, Silke; Oeck, Sebastian; Paul, Annika; Liffers, Sven T.; Kaschani, Farnusch; Kaiser, Markus; Schramm, Alexander; Siveke, Jens; Winslow, Monte M.; Fendt, Sarah-Maria; Nalbant, Perihan; Grüner, Barbara M.
    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
    In: Cell Reports Vol. 37 (2021) Nr. 8,
    ISSN: 2211-1247
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)

    • Articles

  • Day, Matthew; Tetik, Bilal; Parlak, Milena Yasemin Jeanne; Almeida-Hernández, Yasser; Räschle, Markus; Kaschani, Farnusch; Siegert, Heike; Marko, Anika; Sanchez-Garcia, Elsa; Kaiser, Markus; Barker, Isabel A.; Pearl, Laurence H.; Oliver, Antony W.; Boos, Dominik;
    Cold Spring Harbor Laboratory (Eds.)
    TopBP1 utilises a bipartite GINS binding mode to activate the replicative helicase
    (2023)
    Online Full Text: dx.doi.org/ (Open Access)
  • d'Amico, Ennio; Ud Din Ahmad, Misbha; Cmentowski, Verena; Girbig, Mathias; Mueller, Franziska; Wohlgemuth, Sabine; Brockmeyer, Andreas; Maffini, Stefano; Janning, Petra; Vetter, Ingrid R.; Carter, Andrew P.; Perrakis, Anastassis; Musacchio, Andrea
    Conformational transitions of the mitotic adaptor Spindly underlie its interaction with Dynein and Dynactin
    (2022)
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Rüttermann, Maximilian; Koci, Michelle; Lill, Pascal; Klink, Björn Udo; Erdmann, Ralf; Gatsogiannis, Christos
    Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate
    (2022)
    Online Full Text: dx.doi.org/ (Open Access)

    • Book articles / Proceedings papers

  • Schillinger, Jasmin; Hellerschmied-Jelinek, Doris
    Targeted Protein Unfolding at the Golgi Apparatus
    In: Golgi: Methods and Protocols / Wang, Yanzhuang; Lupashin, Vladimir V.; Graham, Todd R. (Eds.) 2022, pp. 645 - 659
    ISBN: 978-1-0716-2639-9; 978-1-0716-2638-2
    Online Full Text: dx.doi.org/

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