Publications
2024
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Lysosomal damage sensing and lysophagy initiation by SPG20-ITCHIn: Molecular Cell (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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Noninvasive minimal residual disease assessment in relapsed/refractory large B-cell lymphoma using digital droplet PCRIn: European Journal of Haematology (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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Structure of the human KMN complex and implications for regulation of its assemblyIn: Nature Structural & Molecular Biology (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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Thirty years of structural changesIn: Nature Structural & Molecular Biology (2024) in pressOnline Full Text: dx.doi.org/
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TopBP1 utilises a bipartite GINS binding mode to support genome replicationIn: Nature Communications Vol. 15 (2024) Nr. 1, 1797Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
Journal articles
2023
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Cdc42 activity in the trailing edge is required for persistent directional migration of keratinocytesIn: Molecular Biology of the Cell Vol. 35 (2023) Nr. 1, br1Online Full Text: dx.doi.org/
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Clp-targeting BacPROTACs impair mycobacterial proteostasis and survivalIn: Cell Vol. 186 (2023) Nr. 10, pp. 2176 - 2192.e22Online Full Text: dx.doi.org/ (Open Access)
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Distinct genetically-determined origins of Myd88/Bcl2-driven aggressive lymphoma rationalize targeted therapeutic intervention strategiesIn: Blood Cancer Discovery Vol. 4 (2023) Nr. 1, pp. 78 - 97Online Full Text: dx.doi.org/ (Open Access)
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HLA class II loss and JAK1/2 deficiency coevolve in melanoma leading to CD4 T cell and IFNγ cross-resistanceIn: Clinical Cancer Research Vol. 29 (2023) Nr. 15, pp. 2894 - 2907Online Full Text: dx.doi.org/
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Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanomaIn: Nature Cancer Vol. 4 (2023) Nr. 9, pp. 1292 - 1308Online Full Text: dx.doi.org/ (Open Access)
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Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36In: Nature Chemical Biology Vol. 19 (2023) Nr. 11, pp. 1394 - 1405Online Full Text: dx.doi.org/ (Open Access)
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RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore coronaIn: The EMBO Journal Vol. 42 (2023) Nr. 24, e114838Online Full Text: dx.doi.org/
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Structural basis of ubiquitin-independent PP1 complex disassembly by p97In: The EMBO Journal Vol. 42 (2023) Nr. 14, e113110Online Full Text: dx.doi.org/ (Open Access)
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Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrateIn: Nature Communications Vol. 14 (2023) Nr. 1, 5942Online Full Text: dx.doi.org/ (Open Access)
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Systematic analysis of microtubule plus-end networks defines EB-cargo complexes critical for mitosis in budding yeastIn: Molecular Biology of the Cell Vol. 34 (2023) Nr. 5, ar37Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Targeting of client proteins to the VCP/p97/Cdc48 unfolding machineIn: Frontiers in Molecular Biosciences Vol. 10 (2023) 1142989Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPaseIn: Nature Communications Vol. 14 (2023) Nr. 1, 3258Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Toward effective Atg8-based ATTECs : Approaches and perspectivesIn: Journal of Cellular Biochemistry (2023) in pressOnline Full Text: dx.doi.org/ (Open Access)
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Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimizationIn: Cell Chemical Biology Vol. 30 (2023) Nr. 7, pp. 753 - 765.e8Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Ubiquitin-mediated degradation at the Golgi apparatusIn: Frontiers in Molecular Biosciences Vol. 10 (2023) 1197921Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Activation of automethylated PRC2 by dimerization on chromatin(2023) 49 SeitenOnline Full Text: dx.doi.org/ (Open Access)
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Ipl1-controlled attachment maturation regulates Mps1 association with its kinetochore receptor(2023) 43 SeitenOnline Full Text: dx.doi.org/ (Open Access)
Journal articles
Articles
2022
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A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing ProteinsIn: Frontiers in Cell and Developmental Biology Vol. 10 (2022) 886537Online Full Text: dx.doi.org/ (Open Access)
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ABP-Finder : A Tool to Identify Antibacterial Peptides and the Gram-Staining Type of Targeted BacteriaIn: Antibiotics Vol. 11 (2022) Nr. 12, 1708Online Full Text: dx.doi.org/ (Open Access)
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An allosteric HTRA1-calpain 2 complex with restricted activation profileIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 119 (2022) Nr. 14, e2113520119Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Chemoproteomics‐Enabled Identification of 4‐Oxo‐β‐Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9In: Angewandte Chemie International Edition Vol. 61 (2022) Nr. 47, e202210498Online Full Text: dx.doi.org/ (Open Access)
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Dimerization of the Peptide CXCR4-Antagonist on Macromolecular and Supramolecular Protraction Arms Affords Increased Potency and Enhanced Plasma StabilityIn: Bioconjugate Chemistry Vol. 33 (2022) Nr. 4, pp. 594 - 607Online Full Text: dx.doi.org/
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Functions and Interactions of Mammalian KDM5 DemethylasesIn: Frontiers in Genetics Vol. 13 (2022)Online Full Text: dx.doi.org/ (Open Access)
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Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicityIn: Journal for ImmunoTherapy of Cancer Vol. 10 (2022) Nr. 6, e003863Online Full Text: dx.doi.org/ (Open Access)
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MCU controls melanoma progression through a redox-controlled phenotype switchIn: EMBO Reports Vol. 23 (2022) Nr. 11, e54746Online Full Text: dx.doi.org/ (Open Access)
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Novel, highly potent PROTACs targeting AURORA-A kinaseIn: Current Research in Chemical Biology Vol. 2 (2022) 100032Online Full Text: dx.doi.org/ (Open Access)
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On the role of phase separation in the biogenesis of membraneless compartmentsIn: The EMBO Journal Vol. 41 (2022) Nr. 5, e109952Online Full Text: dx.doi.org/ (Open Access)
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PPI-Affinity : A Web Tool for the Prediction and Optimization of Protein-Peptide and Protein-Protein Binding AffinityIn: Journal of Proteome Research Vol. 21 (2022) Nr. 8, pp. 1829 - 1841Online Full Text: dx.doi.org/ (Open Access)
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PROTAC degraders as chemical probes for studying target biology and target validationIn: Chemical Society Reviews Vol. 51 (2022) Nr. 18, pp. 7971 - 7993Online Full Text: dx.doi.org/
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Persister state-directed transitioning and vulnerability in melanomaIn: Nature Communications Vol. 13 (2022) Nr. 1, 3055Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Structural basis for specific inhibition of the deubiquitinase UCHL1In: Nature Communications Vol. 13 (2022) Nr. 1, 5950Online Full Text: dx.doi.org/ (Open Access)
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Structure of the RZZ complex and molecular basis of Spindly‐driven corona assembly at human kinetochoresIn: The EMBO Journal Vol. 41 (2022) Nr. 9, e110411Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1In: Molecular Cell Vol. 82 (2022) Nr. 14, pp. 2633 - 2649.e7Online Full Text: dx.doi.org/ (Open Access)
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Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTNIn: The Journal of Biological Chemistry (JBC) Vol. 298 (2022) Nr. 6, 101976Online Full Text: dx.doi.org/ (Open Access)
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Conformational transitions of the mitotic adaptor Spindly underlie its interaction with Dynein and Dynactin(2022)Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate(2022)Online Full Text: dx.doi.org/ (Open Access)
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Targeted Protein Unfolding at the Golgi ApparatusIn: Golgi: Methods and Protocols / Wang, Yanzhuang; Lupashin, Vladimir V.; Graham, Todd R. (Eds.) 2022, pp. 645 - 659Online Full Text: dx.doi.org/
Journal articles
Articles
Book articles / Proceedings papers
2021
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Cdc4 phospho-degrons allow differential regulation of ame1ceⁿp⁻u protein stability across the cell cycleIn: eLife Vol. 10 (2021) e67390Online Full Text: dx.doi.org/ (Open Access)
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Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochoreIn: The EMBO Journal Vol. 40 (2021) Nr. 18, e108004Online Full Text: dx.doi.org/ (Open Access)
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Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasisIn: Cell Reports Vol. 37 (2021) Nr. 8, 110056Online Full Text: dx.doi.org/ Online Full Text (Open Access)