Welcome to the Collaborative Research Centre "Molecular Mechanisms on Cell State Transitions" (CRC 1430). The CRC 1430 brings together scientist of the Center of Medical Biotechnology at the University of Duisburg-Essen, the Max Planck Institute of Molecular Physiology and the Universities of Dortmund, Münster, Cologne and Frankfurt.

About

The DFG-funded CRC 1430 "Molecular Mechanisms of Cell State Transitions" explores fundamental molecular mechanisms that underlie the regulation of cell proliferation. Cell proliferation needs to be tightly controlled to ensure organismal development and tissue regeneration, while preventing neoplastic disorders. A key hallmark of this control is the establishment of distinct, biochemically or epigenetically defined cell states and the regulated transitions between these states.

These transitions govern cell cycle progression and underlie cancer cell plasticity and cancer therapy resistance. The research focus is on understanding the switch-like molecular trigger mechanisms of state transitions and develop means to modulate them, ultimately to identify novel therapeutic strategies. Specifically, to overcome current limitations, the CRC 1430 will develop and apply direct methodologies such as advanced biochemical reconstitution and novel approaches of acute chemical or optical perturbation to decipher how the key triggers sense, integrate and transmit signals to regulatory circuits that define cell states.

Latest

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NEWS

Upcoming CRC 1430 Retreat & Symposium 2023

Save-the-date for our

upcoming CRC 1430 Retreat 2023 (in summer of 2023) and

upcoming CRC 1430 International Symposium (in the fall of 2023).

Dates and more information will follow soon.

Upcoming CRC 1430 Guest Lectures

Recent guests:

Alwin Köhler (Max Perutz Labs Vienna),
Petra Beli (Johannes Gutenberg-University Mainz),
Stefanie Jonas (ETH Zürich), and
Dana Branzei (IGM Pavia).

July 18, 2022 Congratulations!

Beatrice Thier’s (Paschen lab) presentation of her work on Melanoma cell state transition (recently published in JITC) received the 1st poster prize at the TIMO XVI conference.

Work of grad student Jason Mak (Musacchio lab) on bioconjugation was honored with a poster prize at the Biochemistry 2022 meeting of the GDCh.

 

© J Proteome Res

Aug 21, 2022 Novel Web Tool PPI-Affinity

A new paper is out, published in the Journal of Proteome Research with a cover image featured in the current issue. It introduces PPI-Affinity, a web tool developed by scientists of the groups of Elsa Sánchez García and Michael Ehrmann.  The web server scores protein–protein and protein–peptide complexes based on their predicted binding affinity and also optimizes the affinity of a complex by mutating and screening selected residues. PPI-Affinity can be employed at early steps of drug design processes and thus support the design of new  therapeutics significantly.

PPI-Affinity is freely accessible at https://protdcal.zmb.uni-due.de/PPIAffinity.

Romero-Molina S, Ruiz-Blanco YB, Mieres-Perez J, Harms M, Münch J, Ehrmann M,
Sanchez-Garcia E. PPI-Affinity: A Web Tool for the Prediction and Optimization J Proteome Res. 2022
Aug 5;21(8):1829-1841.

Publications

    Journal articles

  • Pavlenko, Egor; Ruengeler, Till; Engel, Paulina; Poepsel, Simon
    Functions and Interactions of Mammalian KDM5 Demethylases
    In: Frontiers in Genetics Vol. 13 (2022)
    ISSN: 1664-8021
  • Thier, Beatrice; Zhao, Fang; Stupia, Simone; Brüggemann, Alicia; Koch, Johannes; Schulze, Nina; Horn, Susanne; Coch, Christoph; Hartmann, Gunther; Sucker, Antje; Schadendorf, Dirk; Paschen, Annette
    Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicity
    In: Journal for ImmunoTherapy of Cancer Vol. 10 (2022) Nr. 6,
    ISSN: 2051-1426
  • Musacchio, Andrea
    On the role of phase separation in the biogenesis of membraneless compartments
    In: The EMBO Journal Vol. 41 (2022) Nr. 5,
    ISSN: 0261-4189; 1460-2075
  • Romero-Molina, Sandra; Ruiz-Blanco, Yasser B.; Mieres-Perez, Joel; Harms, Mirja; Münch, Jan; Ehrmann, Michael; Sanchez-Garcia, Elsa
    PPI-Affinity : A Web Tool for the Prediction and Optimization of Protein-Peptide and Protein-Protein Binding Affinity
    In: Journal of Proteome Research Vol. 21 (2022) Nr. 8, pp. 1829 - 1841
    ISSN: 1535-3907; 1535-3893
  • Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Jürgen; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodríguez-López, José Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Rösch, Alexander
    Persister state-directed transitioning and vulnerability in melanoma
    In: Nature Communications Vol. 13 (2022) Nr. 1,
    ISSN: 2041-1723
  • Raisch, Tobias; Ciossani, Giuseppe; d’Amico, Ennio; Cmentowski, Verena; Carmignani, Sara; Maffini, Stefano; Merino, Felipe; Wohlgemuth, Sabine; Vetter, Ingrid R.; Raunser, Stefan; Musacchio, Andrea
    Structure of the RZZ complex and molecular basis of Spindly‐driven corona assembly at human kinetochores
    In: The EMBO Journal (2022)
    ISSN: 0261-4189; 1460-2075
  • Kravić, Bojana; Bionda, Tihana; Siebert, Alexander; Gahlot, Pinki; Levantovsky, Sophie; Behrends, Christian; Meyer, Hemmo
    Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1
    In: Molecular Cell Vol. 82 (2022) Nr. 14, pp. 2633 - 2649.e7
    ISSN: 1097-2765; 1097-4164
  • Kröning, Alexander; van den Boom, Johannes; Kracht, Matthias; Kück, Anja; Meyer, Hemmo
    Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTN
    In: The Journal of Biological Chemistry (JBC) Vol. 298 (2022) Nr. 6,
    ISSN: 0021-9258; 1083-351X
  • Böhm, Miriam; Killinger, Kerstin; Dudziak, Alexander; Pant, Pradeep; Jänen, Karolin; Hohoff, Simone; Mechtler, Karl; Örd, Mihkel; Loog, Mart; Sánchez-García, Elsa; Westermann, Stefan
    Cdc4 phospho-degrons allow differential regulation of ame1ceⁿp⁻u protein stability across the cell cycle
    In: eLife Vol. 10 (2021)
    ISSN: 2050-084X
  • Dudziak, Alexander; Engelhard, Lena; Bourque, Cole; Klink, Björn Udo; Rombaut, Pascaline; Kornakov, Nikolay; Jänen, Karolin; Herzog, Franz; Gatsogiannis, Christos; Westermann, Stefan
    Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochore
    In: The EMBO Journal Vol. 40 (2021) Nr. 18,
    ISSN: 0261-4189; 1460-2075
  • Dorsch, Madeleine; Kowalczyk, Manuela; Planque, Mélanie; Heilmann, Geronimo; Urban, Sebastian; Dujardin, Philip; Forster, Jan; Ueffing, Kristina; Nothdurft, Silke; Oeck, Sebastian; Paul, Annika; Liffers, Sven T.; Kaschani, Farnusch; Kaiser, Markus; Schramm, Alexander; Siveke, Jens; Winslow, Monte M.; Fendt, Sarah-Maria; Nalbant, Perihan; Grüner, Barbara M.
    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
    In: Cell Reports Vol. 37 (2021) Nr. 8,
    ISSN: 2211-1247
  • Articles

  • d'Amico, Ennio; Ud Din Ahmad, Misbha; Cmentowski, Verena; Girbig, Mathias; Mueller, Franziska; Wohlgemuth, Sabine; Brockmeyer, Andreas; Maffini, Stefano; Janning, Petra; Vetter, Ingrid R.; Carter, Andrew P.; Perrakis, Anastassis; Musacchio, Andrea
    Conformational transitions of the mitotic adaptor Spindly underlie its interaction with Dynein and Dynactin
    (2022)

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