CRC 1430

Welcome to the Collaborative Research Centre "Molecular Mechanisms of Cell State Transitions" (CRC 1430)

The DFG-funded CRC 1430 "Molecular Mechanisms of Cell State Transitions" explores fundamental molecular mechanisms that underlie the regulation of cell proliferation. Cell proliferation needs to be tightly controlled to ensure organismal development and tissue regeneration, while preventing neoplastic disorders. A key hallmark of this control is the establishment of distinct, biochemically or epigenetically defined cell states and the regulated transitions between these states.  ​
These transitions govern cell cycle progression and underlie cancer cell plasticity and cancer therapy resistance. The research focus is on understanding the switch-like molecular trigger mechanisms of state transitions and develop means to modulate them, ultimately to identify novel therapeutic strategies. Specifically, to overcome current limitations, the CRC 1430 will develop and apply direct methodologies such as advanced biochemical reconstitution and novel approaches of acute chemical or optical perturbation to decipher how the key triggers sense, integrate and transmit signals to regulatory circuits that define cell states.

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Upcoming CRC 1430 Guest Lectures

27.02.2024 Boris Pfander
DOLCE (Dortmund Life Science Center), TU Dortmund
30.04.2024 Monilola Olayioye
Institute of Cell Biology and Immunology, University of Stuttgart
04.06.2024 Silvia Vega Rubin de Celis
Institut für Zellbiologie (Tumorforschung), UKE
26.11.2024 Georg Winter
Center for Molecular Medicine, Austrian Academy of Sciences

Further information


A list of previous speakers can be found here:

Previous Speaker

Upcoming CRC1430 Workshops

16.11.2023 Story Telling Techniques for Scientific Presentations
Guido Molina
29.11.2023 Introduction to R

Further information


A list of previous workshops can be found here:

Previous Workshops


Mikroskopische Aufnahme einer migrierenden menschlichen Hautzelle.
©Perihan Nalbant

February 01, 2024 How Cells migrate

Two new papers on cell migration were published by Prof. Dr. Perihan Nalbant (MB) in cooperation with Dr. Leif Dehmelt (Chemistry and Chemical Biology, TU Dortmund).

For efficient cell migration dynamic cell shape changes need to be coordinated. Most cell types form protrusions in the front and a retracting tail. In these two papers the groups used TIRF microscopy and translocation sensors to measure Rho GTPase activity which play a key role in the spatio-temporal coordination of  the relevant cytoskeletal dynamics.

Nature Communications and Molecular Biology of the Cell

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©UDE/Bettina Engel-Albustin

October 10-12, 2023 1st International Symposium: "Triggers of Cell State Transitions"

We thank all speakers and participants for contributing to the success of our 1st International Symposium Triggers of Cell State Transitions!

Location: Glaspavillon, University Duisburg-Essen, Campus Essen

Confirmed Speakers

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New Associated PI Katarzyna Kliza joins the CRC1430

The CRC1430 is pleased to welcome Dr. Katarzyna Kliza as an associated principal investigator. Katarzyna is a Research Group Leader at the MPI of Molecular Physiology, where she is engaged in studying the Decoding of Post-Translational Modification Signalling Networks, with a specific focus on ADP-ribosylation. Her research involves a multifaceted and interdisciplinary approach, incorporating proteomics, biochemistry, molecular, and cell biology techniques.

We´re looking forward to future collaborations!