Welcome to the Collaborative Research Centre "Molecular Mechanisms on Cell State Transitions" (CRC 1430). The CRC 1430 brings together scientist of the Center of Medical Biotechnology at the University of Duisburg-Essen, the Max Planck Institute of Molecular Physiology and the Universities of Dortmund, Münster, Cologne and Frankfurt.

About

The DFG-funded CRC 1430 "Molecular Mechanisms of Cell State Transitions" explores fundamental molecular mechanisms that underlie the regulation of cell proliferation. Cell proliferation needs to be tightly controlled to ensure organismal development and tissue regeneration, while preventing neoplastic disorders. A key hallmark of this control is the establishment of distinct, biochemically or epigenetically defined cell states and the regulated transitions between these states.

These transitions govern cell cycle progression and underlie cancer cell plasticity and cancer therapy resistance. The research focus is on understanding the switch-like molecular trigger mechanisms of state transitions and develop means to modulate them, ultimately to identify novel therapeutic strategies. Specifically, to overcome current limitations, the CRC 1430 will develop and apply direct methodologies such as advanced biochemical reconstitution and novel approaches of acute chemical or optical perturbation to decipher how the key triggers sense, integrate and transmit signals to regulatory circuits that define cell states.

NEWS

We are hiring Open Positions

CRC 1430 is looking to fill positions for doctoral and postdoctoral researchers. In the upcoming weeks we will continuously publish our vacancies.

Open positions

Neuer Sonderforschungsbereich Molekulare Mechanismen der Zellvermehrung entschlüsseln

[25.05.2021] Damit sich ein Organismus entwickeln und regenerieren kann, müssen sich Zellen vermehren. Während der Vermehrung werden nacheinander mehrere genau definierte Zustände durchlaufen, deren Übergänge strikt reguliert werden. Die hierfür zentralen molekularen Mechanismen untersucht jetzt ein neuer Sonderforschungsbereich (SFB), den die Deutsche Forschungsgemeinschaft (DFG) an der Universität Duisburg-Essen (UDE) eingerichtet hat.

UDE Press Release

25. Mai 2021 DFG fördert elf neue Sonder­forschungs­bereiche

Die Deutsche Forschungsgemeinschaft (DFG) richtet zur weiteren Stärkung der Spitzenforschung an den Hochschulen elf neue Sonderforschungsbereiche (SFB) ein. Dies beschloss der zuständige Bewilligungsausschuss, der wegen der Coronavirus-Pandemie per Videokonferenz tagte. Die neuen SFB werden ab dem 1. Juli 2021 zunächst vier Jahre lang mit insgesamt rund 138 Millionen Euro gefördert.

DFG Press Release

The integrated Research Training Group on Molecular and Chemical Cell Biology of CRC 1430 has now been officially incorporated into UDE´s Graduate School of Biomedical Science - BIOME.

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First Publication Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochore.

In our bodies several hundred billions of cells divide each day to replenish tissues and maintain important functions of our organism. The proliferation of cells requires that their genetic blueprint, packaged in the form of chromosomes, is precisely copied and distributed between the daughter cells during each cell division. Crucial for this process is the correct attachment of chromosomes to microtubule filaments of the mitotic spindle, mediated by a large protein complex termed the kinetochore.

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Projects

Our interdisciplinary effort integrates the complementing expertise of biologists, molecular oncologists and chemists for a concerted approach to unravel molecular trigger mechanisms of cell state transitions in different aspects of cell proliferation and to develop molecular and chemical tools to monitor and modulate these transitions.
List of Projects

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