CRC 1430 Welcome
Welcome to the Collaborative Research Centre "Molecular Mechanisms on Cell State Transitions" (CRC 1430). The CRC 1430 brings together scientist of the Center of Medical Biotechnology at the University of Duisburg-Essen, the Max Planck Institute of Molecular Physiology and the Universities of Dortmund, Münster, Cologne and Frankfurt.
The DFG-funded CRC 1430 "Molecular Mechanisms of Cell State Transitions" explores fundamental molecular mechanisms that underlie the regulation of cell proliferation. Cell proliferation needs to be tightly controlled to ensure organismal development and tissue regeneration, while preventing neoplastic disorders. A key hallmark of this control is the establishment of distinct, biochemically or epigenetically defined cell states and the regulated transitions between these states.
These transitions govern cell cycle progression and underlie cancer cell plasticity and cancer therapy resistance. The research focus is on understanding the switch-like molecular trigger mechanisms of state transitions and develop means to modulate them, ultimately to identify novel therapeutic strategies. Specifically, to overcome current limitations, the CRC 1430 will develop and apply direct methodologies such as advanced biochemical reconstitution and novel approaches of acute chemical or optical perturbation to decipher how the key triggers sense, integrate and transmit signals to regulatory circuits that define cell states.
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Upcoming CRC 1430 Retreat & Symposium 2023
Save-the-date for our
upcoming CRC 1430 Retreat 2023 (in summer of 2023) and
upcoming CRC 1430 International Symposium (in the fall of 2023).
Dates and more information will follow soon.
Upcoming CRC 1430 Guest Lectures
Alwin Köhler (Max Perutz Labs Vienna),
Petra Beli (Johannes Gutenberg-University Mainz),
Stefanie Jonas (ETH Zürich), and
Dana Branzei (IGM Pavia).
July 18, 2022 Congratulations!
Beatrice Thier’s (Paschen lab) presentation of her work on Melanoma cell state transition (recently published in JITC) received the 1st poster prize at the TIMO XVI conference.
Work of grad student Jason Mak (Musacchio lab) on bioconjugation was honored with a poster prize at the Biochemistry 2022 meeting of the GDCh.
Aug 21, 2022 Novel Web Tool PPI-Affinity
A new paper is out, published in the Journal of Proteome Research with a cover image featured in the current issue. It introduces PPI-Affinity, a web tool developed by scientists of the groups of Elsa Sánchez García and Michael Ehrmann. The web server scores protein–protein and protein–peptide complexes based on their predicted binding affinity and also optimizes the affinity of a complex by mutating and screening selected residues. PPI-Affinity can be employed at early steps of drug design processes and thus support the design of new therapeutics significantly.
PPI-Affinity is freely accessible at https://protdcal.zmb.uni-due.de/PPIAffinity.
Romero-Molina S, Ruiz-Blanco YB, Mieres-Perez J, Harms M, Münch J, Ehrmann M,
Sanchez-Garcia E. PPI-Affinity: A Web Tool for the Prediction and Optimization J Proteome Res. 2022
Functions and Interactions of Mammalian KDM5 DemethylasesIn: Frontiers in Genetics Vol. 13 (2022)
Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicityIn: Journal for ImmunoTherapy of Cancer Vol. 10 (2022) Nr. 6,
On the role of phase separation in the biogenesis of membraneless compartmentsIn: The EMBO Journal Vol. 41 (2022) Nr. 5,
ISSN: 0261-4189; 1460-2075
PPI-Affinity : A Web Tool for the Prediction and Optimization of Protein-Peptide and Protein-Protein Binding AffinityIn: Journal of Proteome Research Vol. 21 (2022) Nr. 8, pp. 1829 - 1841
ISSN: 1535-3907; 1535-3893
Persister state-directed transitioning and vulnerability in melanomaIn: Nature Communications Vol. 13 (2022) Nr. 1,
Structure of the RZZ complex and molecular basis of Spindly‐driven corona assembly at human kinetochoresIn: The EMBO Journal (2022)
ISSN: 0261-4189; 1460-2075
Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1In: Molecular Cell Vol. 82 (2022) Nr. 14, pp. 2633 - 2649.e7
ISSN: 1097-2765; 1097-4164
Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTNIn: The Journal of Biological Chemistry (JBC) Vol. 298 (2022) Nr. 6,
ISSN: 0021-9258; 1083-351X
Cdc4 phospho-degrons allow differential regulation of ame1ceⁿp⁻u protein stability across the cell cycleIn: eLife Vol. 10 (2021)
Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochoreIn: The EMBO Journal Vol. 40 (2021) Nr. 18,
ISSN: 0261-4189; 1460-2075
Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasisIn: Cell Reports Vol. 37 (2021) Nr. 8,
Conformational transitions of the mitotic adaptor Spindly underlie its interaction with Dynein and Dynactin(2022)