CRC 1430

Welcome to the Collaborative Research Centre "Molecular Mechanisms of Cell State Transitions" (CRC 1430)

CRC1430 Uebersicht
© UDE/Bettina Engel-Albustin/Daniel Schuhmann

The DFG-funded CRC 1430 "Molecular Mechanisms of Cell State Transitions" explores fundamental molecular mechanisms that underlie the regulation of cell proliferation. Cell proliferation needs to be tightly controlled to ensure organismal development and tissue regeneration, while preventing neoplastic disorders. A key hallmark of this control is the establishment of distinct, biochemically or epigenetically defined cell states and the regulated transitions between these states.  ​
These transitions govern cell cycle progression and underlie cancer cell plasticity and cancer therapy resistance. The research focus is on understanding the switch-like molecular trigger mechanisms of state transitions and develop means to modulate them, ultimately to identify novel therapeutic strategies. Specifically, to overcome current limitations, the CRC 1430 will develop and apply direct methodologies such as advanced biochemical reconstitution and novel approaches of acute chemical or optical perturbation to decipher how the key triggers sense, integrate and transmit signals to regulatory circuits that define cell states.

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Students attending a lecture
© UDE/Bettina Engel-Albustin

Upcoming CRC 1430 Guest Lectures

30.04.2024 Monilola Olayioye
Institute of Cell Biology and Immunology, University of Stuttgart
04.06.2024 Silvia Vega Rubin de Celis
Institut für Zellbiologie (Tumorforschung), UKE
25.06.2024 Yogesh Kulathu
MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee
23.07.2024 Jacques Neefjes
Cell and Chemical Biology, Leiden University Medical Center
29.10.2024 Sandra Iden
Cell & Developmental Biology, Saarland University
26.11.2024 Georg Winter
Center for Molecular Medicine, Austrian Academy of Sciences

Further information

 

A list of previous speakers can be found here:

Previous Speaker

Practical Training
© Sarah Scharfenberg

Upcoming CRC1430 Workshops

03.07.2024 Smart Work in Academia
Berlin Alley, Dr. Stephan Pfob
05.-06.09.2024 GraphPad Prism Introduction
STATCON
18.-19.11.2024 Essentials of Scientific Writing Workshop
BETA Academics, Dr. Deborah Bennett
04.-05.12.2024 Communicating effectively in in multi-national scientific teams
Prosciencia, Dr. Imke Lohde

Further information

 

A list of previous workshops can be found here:

Previous Workshops

NEWS

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Data Management Project INF Open Position - Data Steward

The Project group INF develops the appropriate infrastructure for data handling storage and documentation for the considerable amount of data collected at the CRC1430. It offers numerous opportunities to work at the interface of biomedical research, information sciences, and computer science. Another focus lies on the management of microscopy data, which is established at the Imaging Center Campus Essen (ICCE).

Become part of the Faculty of Biology and Center of Medical Biotechnology at the Campus Essen and apply for the position until the 13th of June 2024!

 

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© Pleuger/Westermann

May 21st 2024 Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptor

During cell division the genetic blueprint of an organism is distributed equally between two daughter cells. Eukaryotic cells have evolved a powerful control mechanism which ensures that cell division only proceeds when chromosomes have achieved error-free attachments to the mitotic spindle. In the latest volume of Current Biology, a paper from Stefan Westermann (A1) and his group in collaboration with Andrea Musacchio (A2), Markus Kaiser (B1), and Farnusch Kaschani (Z3) was released. The study sheds light on the long lasting question how cells coordinate the metaphase-anaphase transition with correct spindle attachments. Pleuger et al. define a binding interface of the regulatory kinase Mps1 at the kinetochore, anchor for spindle attachments at the chromosomes as well as signaling hub for mitotic progression. They proceed by showing that the maturation of correct end-on attachments results in the displacement of Mps1 from kinetochores and identify the molecular features of the outer kinetochore leading to the regulation.

 

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May-December Sex and Gender in the Life Sciences

The new lecture series, “Sex and Gender in the Life Sciences,” aims to showcase perspectives on how research in the life sciences can utilize the analytical potential of the gender dimension. The CRC 1430, along with six other major DFG networks at the University of Duisburg-Essen, are participating in this innovative seminar series. This initiative is led by UDE’s strategic research area "Biomedical Sciences," represented by the Erwin L. Hahn Institute (ELH), the Center of Medical Biotechnology (ZMB), and the Essen College of Gender Research.

 

 

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Every 6 weeks Female Scientists Get-Together

The CRC 1430 organized another get-together giving the female members of the CRC1430 a chance to exchange their experiences in scientific research and engage in discussions on how to support the carreers of women. These meetings take place alternatley in the UKE "casino" and at campus Essen at "Brücke" every 6 weeks, giving female scientists the chance to network and discuss various topics.

Join us for our next get-together at “Brücke” June 19th!

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March 18th 2024 Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH

The latest paper by Pinki Gahlot from the Meyer lab (A03), published in Molecular Cell, reveals how human cells detect and respond to lipid bilayer disruptions in compromised lysosomes, leading to lysophagy via ubiquitin-triggered pathways instead of membrane repair. SPG20, binding to the repair factor IST1, detects damage-associated lipid-packing defects before membrane rupture. These extensive defects lead SPG20 to recruit and activate ITCH, initiating lysophagy to eliminate the damaged lysosome. These findings underscore the importance of coordinated lysosomal damage responses for maintaining cellular homeostasis.

Read more on the newly decoded signaling pathway for the decomposition of damaged lysosomes here.

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© M. Parlak

14 March 2024 PhD thesis defense

Congratulations to Kristina Mrug, who successfully defended her PhD thesis "Regulation of the pulsatory contraction signal network dynamics during cell division" on March 14, 2024.

Project A08

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