During cell division the genetic blueprint of an organism is distributed equally between two daughter cells. Eukaryotic cells have evolved a powerful control mechanism which ensures that cell division only proceeds when chromosomes have achieved error-free attachments to the mitotic spindle. In the latest volume of Current Biology, a paper from Stefan Westermann (A1) and his group in collaboration with Andrea Musacchio (A2), Markus Kaiser (B1), and Farnusch Kaschani (Z3) was released. The study sheds light on the long lasting question how cells coordinate the metaphase-anaphase transition with correct spindle attachments. Pleuger et al. define a binding interface of the regulatory kinase Mps1 at the kinetochore, anchor for spindle attachments at the chromosomes as well as signaling hub for mitotic progression. They proceed by showing that the maturation of correct end-on attachments results in the displacement of Mps1 from kinetochores and identify the molecular features of the outer kinetochore leading to the regulation.

The new lecture series, “Sex and Gender in the Life Sciences,” aims to showcase perspectives on how research in the life sciences can utilize the analytical potential of the gender dimension. The CRC 1430, along with six other major DFG networks at the University of Duisburg-Essen, are participating in this innovative seminar series. This initiative is led by UDE’s strategic research area "Biomedical Sciences," represented by the Erwin L. Hahn Institute (ELH), the Center of Medical Biotechnology (ZMB), and the Essen College of Gender Research.

The CRC 1430 organized another get-together giving the female members of the CRC1430 a chance to exchange their experiences in scientific research and engage in discussions on how to support the carreers of women. These meetings take place alternatley in the UKE "casino" and at campus Essen at "Brücke" every 6 weeks, giving female scientists the chance to network and discuss various topics.

Join us for our next get-together at “Brücke” June 19th!