Prof. Dr. Doris Hellerschmied

Mechanistic Cell Biology

University of Duisburg-Essen

Phone: +49 201 183 3120
Email

The Golgi apparatus is a highly dynamic organelle, which undergoes dramatic structural rearrangements during cell cycle transitions. When the organelle experiences stress and its vital functions are compromised, the cell initiates stress response programs. These response programs aim to ensure resources are spent on restoring cellular health and prevent the formation of damaged daughter cells (internal stress) in a non-optimal environment (external stress). Using cell and chemical biology techniques combined with biochemical approaches, we aim to understand how Golgi stress impacts cell cycle transitions at a molecular level, with the long-term perspective of uncovering Golgi stress pathways, which could be targeted in cancer.