Prof. Dr. Michael Ehrmann

Ehrmann Lab

University of Duisburg-Essen

Phone: +49 201 183 2949
Email

Proteostasis is the balance between synthesis and degradation of proteins. It is maintained by sophisticated networks of biological quality control systems that coordinate protein synthesis with degradation. As balanced proteostasis is a key determinant of successful cell division, challenging cell cycle control mechanisms by applying proteotoxic stresses represents a promising strategy to gain novel and deeper insights into the regulation of cell state transitions. This project will address the implications of the widely conserved serine protease HTRA1 in these events. Recent work indicates that HTRA1 performs protein quality control and affects cell cycle progression. Our studies aim at revealing how HTRA1 senses and modulates proteotoxic stress as well as its implications in the cell cycle and the modulation of checkpoint signalling and activity.