ZMB Member Doris Hellerschmied-Jelinek

ZMB Member
Doris Hellerschmied-Jelinek

Next ZMB-Member
Doris Hellerschmied-Jelinek portrait
© D. Hellerschmied-Jelinek

Prof. Dr. Doris Hellerschmied-Jelinek

Group

Mechanistic Cell Biology

Center of Medical Biotechnology
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen

Research Overview

Understanding how cells maintain homeostasis is critical to understanding cell survival during stress. Cells have to withstand stress from changing environmental conditions, such as temperature, pH, nutrient or oxygen supply, but also during cell differentiation and aging. Eukaryotic cells have evolved to use distinct cellular compartments, known as organelles, which maintain homeostatic mechanisms to ensure their distinct functionalities and overall cellular homeostasis. Within the secretory pathway, these stress response mechanisms have been extensively studied at the level of the endoplasmic reticulum (ER). In contrast, the mechanism(s) by which the Golgi apparatus deals with unfolded proteins and how it reacts to stress are only beginning to be unraveled.
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Publications

    Journal articles

  • Sewald, Leonard; Molke, Niko; Tabak, Werner W. A.; Haak, Anette; Najdzion, Maja; Geiss-Friedlander, Ruth; Hellerschmied, Doris; Huber, Robert; Kaiser, Markus
    A Photocaged N-Phosphonopiperidinone as a Selective Photo-Cleavable DPP8/9 Inhibitor
    In: ChemBioChem, Vol. 26, 2025, Nr. 19, e202500558
    DOI (Open Access)
  • Brenner, Joel Cyrille; Zirden, Linda; Almeida-Hernandez, Yasser; Kaschani, Farnusch; Kaiser, Markus; Sanchez-Garcia, Elsa; Poepsel, Simon; Hellerschmied-Jelinek, Doris
    Conformational plasticity of a BiP-GRP94 chaperone complex
    In: Nature Structural & Molecular Biology, Vol. 32, 2025, Nr. 10, pp. 1947 – 1958
    DOI (Open Access)
  • Hagemeier, Birte; Ripkens, Kamilla; Schulze, Nina; Bluemke, Anika; Strzala, Michal; Koci, Michelle; Kaschani, Farnusch; Kaiser, Markus; Erkelenz, Michael; Schluecker, Sebastian; Merdanovic, Melisa; Poepsel, Simon; Hellerschmied, Doris; Burston, Steven G.; Ehrmann, Michael
    The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations
    In: The Journal of Biological Chemistry (JBC), Vol. 301, 2025, Nr. 10, 110729
    DOI, Online Full Text (Open Access)
  • Schillinger, Jasmin; Koci, Michelle; Bravo-Rodriguez, Kenny; Heilmann, Geronimo; Kaschani, Farnusch; Kaiser, Markus; Beuck, Christine; Luecke, Hartmut; Huber, Robert; Hellerschmied-Jelinek, Doris; Burston, Steven G.; Ehrmann, Michael
    High resolution analysis of proteolytic substrate processing
    In: The Journal of Biological Chemistry (JBC), Vol. 300, 2024, Nr. 11, 107812
    DOI (Open Access)
  • Pol, Savina Abraham; Liljenberg, Sara; Barr, Jack; Simon, Gina; Wong-Dilworth, Luis; Paterson, Danielle L.; Berishvili, Vladimir P.; Bottanelli, Francesca; Kaschani, Farnusch; Kaiser, Markus; Pettersson, Mariell; Hellerschmied, Doris
    Induced degradation of SNAP-fusion proteins
    In: RSC Chemical Biology, Vol. 5, 2024, Nr. 12, pp. 1232 – 1247
    DOI (Open Access)
  • Buzuk, Lana; Hellerschmied-Jelinek, Doris
    Ubiquitin-mediated degradation at the Golgi apparatus
    In: Frontiers in Molecular Biosciences, Vol. 10, 2023, 1197921
    DOI, Online Full Text (Open Access)
  • Schillinger, Jasmin; Hellerschmied, Doris
    Zellen unter Stress : Entspannung mit Hilfe von Proteinen
    In: Unikate: Berichte aus Forschung und Lehre, 2021, Nr. 56, Heft "Junge Wilde" - Die nächste Generation
    DOI, Online Full Text (Open Access)
  • Hellerschmied, Doris; Lehner, Anita; Franicevic, Nina; Arnese, Renato; Johnson, Chloe; Vogel, Antonia; Meinhart, Anton; Kurzbauer, Robert; Deszcz, Luiza; Gazda, Linn; Geeves, Michael; Clausen, Tim
    Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin
    In: Nature Communications, Vol. 10, 2019, Nr. 1, 4781
    DOI (Open Access)
  • Hellerschmied, Doris; Serebrenik, Yevgeniy V.; Shao, Lin; Burslem, George M.; Crews, Craig M.
    Protein folding state-dependent sorting at the Golgi apparatus
    In: Molecular Biology of the Cell, Vol. 30, 2019, Nr. 17, pp. 2296 – 2308
    DOI (Open Access)
  • Serebrenik, Yevgeniy V.; Hellerschmied, Doris; Toure, Momar; López-Giráldez, Francesc; Brookner, Dennis; Crews, Craig M.
    Targeted protein unfolding uncovers a Golgi-specific transcriptional stress response
    In: Molecular Biology of the Cell, Vol. 29, 2018, Nr. 11, pp. 1284 – 1298
    DOI (Open Access)
  • Hellerschmied, Doris; Roessler, Max; Lehner, Anita; Gazda, Linn; Stejskal, Karel; Imre, Richard; Mechtler, Karl; Dammermann, Alexander; Clausen, Tim
    UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins
    In: Nature Communications, Vol. 9, 2018, Nr. 1, 484
    DOI (Open Access)
  • Lai, Ashton C.; Toure, Momar; Hellerschmied, Doris; Salami, Jemilat; Jaime-Figueroa, Saul; Ko, Eunhwa; Hines, John; Crews, Craig M.
    Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL
    In: Angewandte Chemie International Edition, Vol. 55, 2016, Nr. 2, pp. 807 – 810
    DOI
  • Schneider, Maren; Hellerschmied, Doris; Schubert, Tobias; Amlacher, Stefan; Vinayachandran, Vinesh; Reja, Rohit; Pugh, B. Franklin; Clausen, Tim; Köhler, Alwin
    The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression
    In: Cell, Vol. 162, 2015, Nr. 5, pp. 1016 – 1028
    DOI (Open Access)
  • Hellerschmied, Doris; Clausen, Tim
    Myosin chaperones
    In: Current Opinion in Structural Biology, Vol. 25, 2014, pp. 9 – 15
    DOI (Open Access)
  • Gazda, Linn; Pokrzywa, Wojciech; Hellerschmied, Doris; Löwe, Thomas; Forné, Ignasi; Mueller-Planitz, Felix; Hoppe, Thorsten; Clausen, Tim
    The Myosin Chaperone UNC-45 Is Organized in Tandem Modules to Support Myofilament Formation in C. elegans
    In: Cell, Vol. 152, 2013, Nr. 1-2, pp. 183 – 195
    DOI (Open Access)
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