ZMB Member Doris Hellerschmied-Jelinek
ZMB Member
Doris Hellerschmied-Jelinek
Next ZMB-Member
Prof. Dr. Doris Hellerschmied-Jelinek
Group
Mechanistic Cell BiologyCenter of Medical Biotechnology
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen
- +49 201 183 3120
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Molecular and Chemical Cell Biology
Research Overview
Understanding how cells maintain homeostasis is critical to understanding cell survival during stress. Cells have to withstand stress from changing environmental conditions, such as temperature, pH, nutrient or oxygen supply, but also during cell differentiation and aging. Eukaryotic cells have evolved to use distinct cellular compartments, known as organelles, which maintain homeostatic mechanisms to ensure their distinct functionalities and overall cellular homeostasis. Within the secretory pathway, these stress response mechanisms have been extensively studied at the level of the endoplasmic reticulum (ER). In contrast, the mechanism(s) by which the Golgi apparatus deals with unfolded proteins and how it reacts to stress are only beginning to be unraveled.
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