Mechanistic Cell Biology
Mechanistic Cell Biology
Prof. Dr. Doris Hellerschmied
Contact
Prof. Dr. Doris Hellerschmied-Jelinek
- +49 201 183 3120
- Doris.Hellerschmied@uni-due.de
- S05 V04 F09
Faculty of Biology
Center of Medical Biotechnology (ZMB)
University of Duisburg-Essen
Research
Chemical Biology to Unravel Protein Homeostasis
Understanding how cells maintain homeostasis is critical to understanding cell survival during stress. Cells have to withstand stress from changing environmental conditions, such as temperature, pH, nutrient or oxygen supply, but also during cell differentiation and aging. Eukaryotic cells have evolved to use distinct cellular compartments, known as organelles, which maintain homeostatic mechanisms to ensure their distinct functionalities and overall cellular homeostasis. Within the secretory pathway, these stress response mechanisms have been extensively studied at the level of the endoplasmic reticulum (ER). In contrast, the mechanism(s) by which the Golgi apparatus deals with unfolded proteins and how it reacts to stress are only beginning to be unraveled.
Selected Publications
Joao Diamantino, Sofia Murteira, Steffen Lawo, Farnusch Kaschani, Markus Kaiser, Doris Hellerschmied.
Selective proteasomal degradation from the Golgi apparatus membrane. (Preprint 2026)
DOI: 10.64898/2026.02.04.703791v1
Brenner, Joel Cyrille; Zirden, Linda Charlotte; Buzuk, Lana; Almeida-Hernandez, Yasser; Radzuweit, Lea; Diamantino, Joao; Kaschani, Farnusch; Kaiser, Markus; Sanchez-Garcia, Elsa; Poepsel, Simon; Hellerschmied-Jelinek, Doris.
Conformational plasticity of a BiP-GRP94 chaperone complex. (2025)
Nat Struct Mol Biol. DOI: 10.1038/s41594-025-01619-0
Abraham Pol, Savina; Liljenberg, Sara; Barr, Jack; Simon, Gina; Wong-Dilworth, Luis; Paterson, Danielle L.; Berishvili, Vladimir P.; Bottanelli, Francesca; Kaschani, Farnusch; Kaiser, Markus; Pettersson, Mariell; Hellerschmied, Doris.
Induced degradation of SNAP-fusion proteins. (2024)
RSC Chem. Biol. DOI: 10.1039/D4CB00184B
Buzuk, Lana; Hellerschmied, Doris.
Ubiquitin-mediated degradation at the Golgi apparatus. (2023)
Frontiers in Molecular Biosciences Vol. 10. DOI: 10.3389/fmolb.2023.1197921
Diamantino, João; Hellerschmied, Doris.
Cellular Principles of Targeted Protein Degradation. (2023)
In Philipp Cromm (Editor): Inducing Targeted Protein Degradation. Wiley, S. 25–62. DOI: 10.1002/9783527836208.ch2
Schillinger, Jasmin; Hellerschmied, Doris.
Targeted Protein Unfolding at the Golgi Apparatus. (2023)
Methods in Molecular Biology 2557, S. 645–659. DOI: 10.1007/978-1-0716-2639-9_39