DFG Consortia

ZMB Research
DFG Consortia

Coordinated Collaborative Research Centers/Transregios (CRC/TRR)

CRC 1430: Molecular Mechanisms of Cell State Transitions

Spokesperson: Prof. Dr. Hemmo Meyer, Center of Medical Biotechnology (ZMB)

Website: https://www.uni-due.de/crc1430/

Project ZMB Member
A01: Molecular control of kinetochore microtubule interactions at the metaphase-anaphase transitionMore Prof. Dr. Stefan Westermann
A02: Bridging the gap between cell biology and biochemistry with artificial protein prosthetics in cell cycle transitionsMore Prof. Dr. Andrea Musacchio
A03: VCP/p97-cofactor complexes at the intersection of DNA repair and checkpoint controlMore Prof. Dr. Hemmo Meyer
A05: A molecular interface linking DNA replication with cell states of different replication competenceMore Prof. Dr. Dominik Boos
A06: Implications of deregulated proteostasis in cell state transitionsMore Prof. Dr. Michael Ehrmann
A07: Golgi stress: impacting cell cycle transitionsMore Prof. Dr. Doris Hellerschmied
A08: Switching of spatio-temporal Rho GTPase signal network dynamics during cell cycle phase transitionsMore Prof. Dr. Perihan Nalbant
A09: Targeting oncogene-induced DNA repair pathway switchesMore Prof. Dr. Christian Reinhardt
A11: Molecular regulation of differentiation and cell cycle in tumor-repopulating melanoma cellsMore Prof. Dr. Alexander Roesch
A13: IFNγ-induced cell state transition in melanomaMore Prof. Dr. Annette Paschen
A14: Metastatic transition in pancreatic ductal adenocarcinomaMore Dr. Barbara Grüner
B01: Developing chemical tools for investigating cell state transitionsMore Prof. Dr. Markus Kaiser
B04: Hybrid computational strategies for the study of cell states transitions and the cell cycleMore Prof. Dr. Elsa Sánchez-García

CRC/TRR 296: Local Control of Thyroid Hormone Action (LOCOTACT)

Spokesperson: Prof. Dr. Dagmar Führer-Sakel, University Hospital Essen

Website: https://www.uni-due.de/crctr296/

Project ZMB Member
P08: Local TH transport and action in ischaemic brain injuryMore Prof. Dr. Dagmar Führer-Sakel
Prof. Dr. Christoph Kleinschnitz
P10: Local TH action in acute and chronic ischaemic heart diseaseMore Prof. Dr. Dagmar Führer-Sakel
Z03: Research Data Management (INF)More Prof. Dr. Dagmar Führer-Sakel

CRC 1093: Supramolecular Chemistry on Proteins

Spokesperson: Prof. Dr. Thomas Schrader, University of Duisburg-Essen

Website: https://www.uni-due.de/crc1093

Project ZMB Member
Protein-recognition by supramolecular ligands from focused combinatorial libraries (A01) More Prof. Dr. Thomas Schrader
Chemical tools from protein class-specific supramolecular ligands (A02) More Prof. Dr. Markus Kaiser
Designed copolymers and molecular tweezers for protein surface recognition (A03) More Prof. Dr. Thomas Schrader
Ultra-small nanoparticles for protein-specific targeting (A05) More Prof. Dr. Matthias Epple
DNA origami nanoarchitectures for predesigned spatial confinement of proteins (A06) More Prof. Dr. Barbara Saccà
Computational design of supramolecular ligands for specific tweaking of protein interactions (A07) More Prof. Dr. Daniel Hoffmann
Exploring protein-recognition by supramolecular binders with MD and QM/MM methods (A08) More Prof. Dr. Elsa Sánchez-García
Raman spectroscopic monitoring of protein recognition by supramolecular ligands (A09) More Prof. Dr. Sebastian Schlücker
Supramolecular ligands modulate assembly and function of HtrA proteases (B01) More Prof. Dr. Michael Ehrmann
Probing mechanisms of the Cdc48/p97 segregase with supramolecular ligands (B02) More Prof. Dr. Hemmo Meyer
Rational targeting of intracellular protein transport signals by supramolecular ligands (B05) More Prof. Dr. Shirley Knauer
Targeting centromere recruitment of mitotic regulators by supramolecular ligands (B06) More Prof. Dr. Andrea Musacchio
Manipulation of the kinetochore-microtubule interface by supramolecular ligands (B07) More Prof. Dr. Stefan Westermann
NMR Spectroscopy (Z03) More Prof. Dr. Peter Bayer

Participation in Collaborative Research Centers/Transregios (CRC/TRR)

CRC/TRR 247: Heterogeneous Oxidation Catalysis in the Liquid Phase – Mechanisms and Materials in Thermal, Electro-, and Photocatalysis

Spokesperson: Prof. Dr. Malte Behrens, University of Duisburg-Essen

Website: https://www.uni-due.de/sfbtrr247/

Project ZMB Member
Pulsed Laser Post Processing of Transition Metal Oxide Nanocatalysts with Defined Defect Structure (C05) More Prof. Dr. Stephan Barcikowski

CRC 1242: Non-equilibrium dynamics of condensed matter in the time domain

Spokesperson: Prof. Dr. Uwe Bovensiepen, University of Duisburg-Essen

Website: http://www.sfb1242.de/

Project ZMB Member
Photoinduced non-equilibrium dynamics in molecular adsorbates: From ensemble to single-molecule experiments (A04) More Prof. Dr. Sebastian Schlücker

CRC 1279: Exploiting the Human Peptidome for Novel Antimicrobial and Anticancer Agents

Spokesperson: Prof. Dr. Frank Kirchhoff, University of Ulm

Website: https://gepris.dfg.de/gepris/projekt/316249678

Project ZMB Member
Characterization and optimization of the CXCR4 antagonist EPI- (A06) More Prof. Dr. Elsa Sánchez-García

CRC 1242: Non-equilibrium dynamics of condensed matter in the time domain

Spokesperson: Prof. Dr. Uwe Bovensiepen, University of Duisburg-Essen

Website: http://www.sfb1242.de/

Project ZMB Member
Photoinduced non-equilibrium dynamics in molecular adsorbates: From ensemble to single-molecule experiments (A04) More Prof. Dr. Sebastian Schlücker

CRC 876: Providing Information by Resource-Constrained Data Analysis

Spokesperson: Prof. Dr. Katharina Morik, TU Dortmund

Website: http://sfb876.tu-dortmund.de/index.html

Project ZMB Member
Feature selection in high dimensional data for risk prognosis in oncology (C01) More Prof. Dr. Sven Rahmann
Prof. Dr. Alexander Schramm

CRC 824: Imaging for Selection, Monitoring and Individualisation of Cancer Therapies

Spokesperson: Prof. Dr. Markus Schwaiger, TU München

Website: http://www.sfb824.de

Project ZMB Member
Molecular and metabolic imaging and targeting of tumor heterogeneity in pancreatic cancer (C04) More Prof. Dr. Jens Siveke

Coordinated Priority Programs (SPP)

SPP 2122: Materials for Additive Manufacturing

Spokesperson: Prof. Dr. Stephan Barcikowski, University of Duisburg-Essen

Website: https://www.uni-due.de/matframe/

Project ZMB Member
Dispersion effects of nanocomposites to improve melting and resolidification behavior during SLS with CO2 and diode lasers More Prof. Dr. Stepahn Barcikowski

SPP 1629: THYROID TRANS ACT - Translation of Thyroid Hormone Actions beyond Classical

Spokesperson: Prof. Dr. Dagmar Führer-Sakel, University Hospital Essen

Website: https://gepris.dfg.de/gepris/projekt/198800877

Project ZMB Member
The tissue-specific role of the murine thyroid hormone transporters Mct8 and Mct10 More Prof. Dr. Heike Heuer
Molecular mechanisms of age-dependent thyroid hormone action on target tissues More Prof. Dr. Dagmar Führer-Sakel
Oral thyroxine resistance revisited - how thyroxine transpasses the gut-blood barrier More Prof. Dr. Dagmar Führer-Sakel
Role of the murine thyroid hormone transporters Mct8 and Oatp1c1 in skeletal muscle, cardiovascular and metabolic system More Prof. Dr. Heike Heuer

Participation in Priority Programs (SPP)

SPP 1926: Next Generation Optogenetics: Tool Development and Application

Spokesperson: Prof. Dr. Alexander Gottschalk, University of Frankfurt

Website: http://www.spp1926.org/

Project ZMB Member
Optogenetic manipulation of cell contraction signal network dynamics in tumors More Prof. Dr. Perihan Nalbant

SPP 1923: Innate Sensing and Restriction of Retroviruses

Spokesperson: Prof. Dr. Oliver Fackler, University Hospital Heidelberg

Website: https://spp1923.de/

Project ZMB Member
Regulation of the induction of IFNα subtypes during HIV infection More Prof. Dr. Ulf Dittmer
Dr. Kathrin Sutter

Coordinated Research Units (FOR)

FOR 2879: ImmunoStroke: From immune cells to stroke recovery

Spokesperson: Prof. Dr. Christoph Kleinschnitz, University Hospital Essen

Website: https://gepris.dfg.de/gepris/projekt/405358801

Project ZMB Member
ImmunoStroke: From Immune cells to stroke recovery Kallikrein-kinin system-mediated thrombo-inflammation as a novel target to improve long-term stroke recoveryMore Prof. Dr. Dirk M. Hermann
ImmunoStroke: From Immune Cells to Stroke Recovery Immune responses controlling post-stroke angiogenesis and microvascular integrityMore Prof. Dr. Matthias Gunzer
Prof. Dr. Dirk M. Hermann
The role of T cells in exercise-induced recovery after stroke More Prof. Dr. Wiebke Hansen

Participation in Research Units (FOR)

FOR 2816: The Autotrophy-Heterotrophy Switch in Cyanobacteria: Coherent Decision-Making at Multiple Regulatory Layers

Spokesperson: Prof. Dr. Jörg Karl Forchhammer, Eberhard Karls University Tübingen

Website: https://gepris.dfg.de/gepris/projekt/397695561

Project ZMB Member
Unraveling the cyanobacterial carbon switch and its regulation using enzyme kinetic analyses and mathematical modeling More Prof. Dr. Bettina Siebers

FOR 2407: Exploring Articular Cartilage and Subchondral Bone Degeneration and Regeneration in Osteoarthritis (ExCarBon)

Spokesperson: Prof. Dr. Susanne Grässel, University of Regensburg

Website: https://www.excarbon.com/

Project ZMB Member
Interaction of heparan sulfate and integrin signaling in maintaining the articular cartilageMore Prof. Dr. Andrea Vortkamp
Prof. Dr. Daniel Hoffmann
Prof. Dr. Perihan Nalbant

FOR 2123: Sphingolipid Dynamics in Infection Control

Spokesperson: Prof. Dr. Sibylle Schneider-Schaulies, University of Würzburg

Website: http://www.virologie.uni-wuerzburg.de/for2123/home0/

Project ZMB Member
Role of neutral sphingomyelinase in mycobacterial infections More Prof. Dr. Erich Gulbins

FOR 1961: Mature T-Cell Lymphomas - Mechanisms of Perturbed Clonal T-Cell Homeostasis

Spokesperson: Prof. Dr. Martin-Leo Hansmann, Goethe-University Frankfurt

Website: https://gepris.dfg.de/gepris/projekt/225165194

Project ZMB Member
Pathogenesis of angioimmunoblastic T-cell lymphoma More Prof. Dr. Ralf Küppers

FOR 1905: Structure and Function of the Peroxisomal Translocon (PerTrans)

Spokesperson: Prof. Dr. Ralf Erdmann, Ruhr University Bochum

Website: http://www.pertrans.org

Project ZMB Member
Structure of the peroxisomal Protein Import Pore: High-Resolution Electron Microscopy More Prof. Dr. Stefan Raunser

Coordinated Clinical Research Units (KFO)

KFO 337: Phenotypic Therapy and Immune Escape in Cancer (PhenoTImE)

Spokesperson: Prof. Dr. Dirk Schadendorf, University Hospital Essen

Website: https://www.uni-due.de/phenotime

Project ZMB Member
Epigenetic-metabolic (‘epi-metabolic’) reprograming as a universal survival strategy in therapy-resistant tumor cell phenotypes More Prof. Dr. Alexander Rösch
Unraveling the phenotypic coevolution of melanoma cells and neutrophils fostering metastasis and therapy resistance More Prof. Dr. Matthias Gunzer
Prof. Dr. Iris Helfrich
Translational validation of genetic and gene expression networks determining the phenotypic switch and therapy resistance of tumor cells More Prof. Dr. Dirk Schadendorf
Defining the role of CIITA in tumor cell-intrinsic and CD4+ T cell-induced phenotype switching and therapy resistance More Prof. Dr. Annette Paschen
Identification of regulators of therapy-induced epithelial mesenchymal plasticity in pancreatic cancer More Prof. Dr. Jens Siveke
Impact of the PI3K/AKT signaling pathway on epigenetic circuitry to generate immune and targeted therapy resistant melanoma phenotypes More Prof. Dr. Jürgen C. Becker

Participation in Cluster of Excellence (EXC)

EXC 2033: RESOLV (Ruhr Explores Solvation)

Spokesperson: Prof. Dr. Martina Havenith-Newen

Website: https://solvation.de

Project ZMB Member
Research Area I: Local Solvent Fluctuations in Heterogeneous Systems More Prof. Dr. Elsa Sánchez-García