ZMB Member Sebastian Schlücker

ZMB Member
Sebastian Schlücker

Next ZMB-Member
Sebastian Schlücker portrait
© S.Schluecker

Prof. Dr. Sebastian Schlücker

Physical Chemistry
Faculty of Chemistry
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen

Research Overview

The Schluecker group is working in the field of Bio- and Nano-Photonics. The rational design and chemical synthesis of tailor-made functionalized metal colloids for bioanalytical and biomedical applications (assays, immunohistochemistry) in combination with optical detection is one focus of our research.

In cooperation with pathologists, we aim at establishing a methodology for highly differentiated, individualized and predictive tumor diagnostics based on a quantitative multi-parameter detection of tumor-relevant biomarkers, in particular for biomarkers in tissues employing in-situ optical imaging approaches. Various methods of optical microscopy and spectroscopy in combination with electron microscopy are employed for the characterization of the physical and chemical properties of our novel nanoparticle-based agents.

The interplay between theory/simulation and experiments is important to us: Starting from the physical description and computation of the optical properties of single gold and silver nanoparticles as well as clusters thereof, we follow a theory-guided approach to rationally design and synthesize functionalized colloids with tailor-made physical and chemical properties. Experiments at the single-particle level are performed in order to unambiguously characterize the physical and chemical properties as well as to establish correlations between structure/morphology and the corresponding properties/optical spectra.

A second line of research is the use of laser spectroscopic techniques for monitoring molecular recognition processes. Data from molecular vibrational spectroscopies are analyzed by multivariate/chemometric techniques and compared with results from computational chemistry. In fundamental methodological work, we have demonstrated that vibrational Raman and mid infrared spectroscopy are ideally suited for quantitative and label-free monitoring of the molecular recognition between small peptides and rationally designed artificial receptors (Schmuck group, organic chemistry, UDE).

Future work aims at quantitative, label-free and in particular site-specific probing of molecular recognition processes between small rationally designed supramolecular ligands and proteins.

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Selected Publications

    Journal articles

  • Hekele, Joscha; Linke, Matthias; Keller, Thomas; Jose, Jesil; Hille, Marvin; Hasselbrink, Eckart; Schlücker, Sebastian; Kratzer, Peter
    A fresh look at the structure of aromatic thiols on Au surfaces from theory and experiment
    In: The Journal of Chemical Physics (JCP) Vol. 155 (2021) Nr. 4,
    ISSN: 1089-7690; 0021-9606
  • Barella, Mariano; Violi, Ianina L.; Gargiulo, Julian; Martinez, Luciana P.; Goschin, Florian; Guglielmotti, Victoria; Pallarola, Diego; Schlücker, Sebastian; Pilo-Pais, Mauricio; Acuna, Guillermo P.; Maier, Stefan A.; Cortes, Emiliano; Stefani, Fernando D.
    In situ photothermal response of single gold nanoparticles through hyperspectral imaging anti-stokes thermometry
    In: ACS Nano Vol. 15 (2021) Nr. 2, pp. 2458 - 2467
    ISSN: 1936-0851; 1936-086X
  • Stepula, Elzbieta; Wang, Xin-Ping; Srivastav, Supriya; König, Matthias; Levermann, Janina; Kasimir-Bauer, Sabine; Schlücker, Sebastian
    6-Color/1-Target Immuno-SERS Microscopy on the Same Single Cancer Cell
    In: ACS Applied Materials & Interfaces Vol. 12 (2020) Nr. 29, pp. 32321 - 32327
    ISSN: 1944-8252; 1944-8244
  • Grzeschik, Roland; Schäfer, Daniel; Holtum, Tim; Küpper, Sebastian; Hoffmann, Axel; Schlücker, Sebastian
    On the overlooked critical role of the pH value on the kinetics of the 4-Nitrophenol NaBH4-reduction catalyzed by noble-metal nanoparticles (Pt, Pd, and Au)
    In: Journal of Physical Chemistry C: Nanomaterials and Interfaces Vol. 124 (2020) Nr. 5, pp. 2939 - 2944
    ISSN: 1932-7455; 1932-7447
  • Langer, Judith; Jimenez De Aberasturi, Dorleta; Aizpurua, Javier; Alvarez-Puebla, Ramon A.; Auguié, Baptiste; Baumberg, Jeremy J.; Bazan, Guillermo C.; Bell, Steven E. J.; Boisen, Anja; Brolo, Alexandre G.; Choo, Jaebum; Cialla-May, Dana; Deckert, Volker; Fabris, Laura; Faulds, Karen; García De Abajo, F. Javier; Goodacre, Royston; Graham, Duncan; Haes, Amanda J.; Haynes, Christy L.; Huck, Christian; Itoh, Tamitake; Käll, Mikael; Kneipp, Janina; Kotov, Nicholas A.; Kuang, Hua; Le Ru, Eric C.; Lee, Hiang Kwee; Li, Jian-Feng; Ling, Xing Yi; Maier, Stefan A.; Mayerhöfer, Thomas; Moskovits, Martin; Murakoshi, Kei; Nam, Jwa-Min; Nie, Shuming; Ozaki, Yukihiro; Pastoriza-Santos, Isabel; Perez-Juste, Jorge; Popp, Juergen; Pucci, Annemarie; Reich, Stephanie; Ren, Bin; Schatz, George C.; Shegai, Timur; Schlücker, Sebastian; Tay, Li-Lin; Thomas, K. George; Tian, Zhong-Qun; Van Duyne, Richard P.; Vo-Dinh, Tuan; Wang, Yue; Willets, Katherine A.; Xu, Chuanlai; Xu, Hongxing; Xu, Yikai; Yamamoto, Yuko S.; Zhao, Bing; Liz-Marzán, Luis M.
    Present and Future of Surface-Enhanced Raman Scattering
    In: ACS Nano Vol. 14 (2020) Nr. 1, pp. 28 - 117
    ISSN: 1936-086X; 1936-0851
  • Bell, Steven E. J.; Charron, Gaëlle; Cortés, Emiliano; Kneipp, Janina; de la Chapelle, Marc Lamy; Langer, Judith; Procházka, Marek; Tran, Vi; Schlücker, Sebastian
    Towards Reliable and Quantitative Surface-Enhanced Raman Scattering (SERS) : From Key Parameters to Good Analytical Practice
    In: Angewandte Chemie International Edition Vol. 59 (2020) pp. 5454 - 5462
    ISSN: 1521-3773; 1433-7851
  • Linke, Matthias; Hille, Marvin; Lackner, Michael; Schumacher, Ludmilla; Schlücker, Sebastian; Hasselbrink, Eckart
    Plasmonic Effects of Au Nanoparticles on the Vibrational Sum Frequency Spectrum of 4-Nitrothiophenol
    In: Journal of Physical Chemistry C: Nanomaterials and Interfaces (2019) pp. 24234 - 24242
    ISSN: 1932-7447; 1932-7455
  • Schumacher, Ludmilla; Jose, Jesil; Janoschka, David; Dreher, Pascal; Davis, Timothy J.; Ligges, Manuel; Li, Renhong; Mo, Mianzhen; Park, Sung Gyu; Shen, Xiu; Weathersby, Stephen P.; Yang, Jie; Wang, Xiangxian; Meyer zu Heringdorf, Frank; Sokolowski-Tinten, Klaus; Schlücker, Sebastian
    Precision Plasmonics with Monomers and Dimers of Spherical Gold Nanoparticles : Nonequilibrium Dynamics at the Time and Space Limits
    In: Journal of Physical Chemistry C: Nanomaterials and Interfaces Vol. 123 (2019) Nr. 21, pp. 13181 - 13191
    ISSN: 1932-7447; 1932-7455
  • Tran, Vi; Walkenfort, Bernd; König, Matthias; Salehi, Mohammad; Schlücker, Sebastian
    Rapid, Quantitative, and Ultrasensitive Point-of-Care Testing : A Portable SERS Reader for Lateral Flow Assays in Clinical Chemistry
    In: Angewandte Chemie International Edition Vol. 58 (2019) Nr. 2, pp. 442 - 446
    ISSN: 1521-3773; 1433-7851
  • Küpper, Sebastian; Kumar, Vikas; Schlücker, Sebastian
    Vibrational Spectroscopic Characterization of 2-(2,4-Dinitrobenzyl)-pyridine (α-DNBP) in Solution by Polarization-Resolved Spontaneous Raman Scattering and Broadband CARS
    In: Journal of Physical Chemistry A: Molecules, Spectroscopy, Kinetics, Environment & General Theory Vol. 123 (2019) Nr. 29, pp. 6291 - 6297
    ISSN: 1089-5639; 1520-5215
  • Cortés, Emiliano; Xie, Wei; Cambiasso, Javier; Jermyn, Adam S.; Sundararaman, Ravishankar; Narang, Prineha; Schlücker, Sebastian; Maier, Stefan A.
    Plasmonic hot electron transport drives nano-localized chemistry
    In: Nature Communications Vol. 8 (2017) pp. 14880
    ISSN: 2041-1723
  • Brem, Svetlana; Schlücker, Sebastian
    Surface-Enhanced raman spectroscopy and density functional theory calculations of a rationally designed rhodamine with thiol groups at the xanthene ring
    In: Journal of Physical Chemistry C: Nanomaterials and Interfaces Vol. 121 (2017) Nr. 28, pp. 15310 - 15317
    ISSN: 1932-7447; 1932-7455
  • Xie, Wei; Schlücker, Sebastian; Grzeschik, Roland
    Metal Nanoparticle-Catalyzed Reduction Using Borohydride in Aqueous Media : A Kinetic Analysis of the Surface Reaction by Microfluidic SERS
    In: Angewandte Chemie International Edition Vol. 55 (2016) Nr. 44, pp. 13729 - 13733
    ISSN: 1521-3773
  • Schütz, Max; Schlücker, Sebastian
    Towards quantitative multi-color nanodiagnostics : spectral multiplexing with six silica-encapsulated SERS labels
    In: Angewandte Chemie International Edition Vol. 47 (2016) Nr. 9, pp. 1012 - 1016
    ISSN: 1521-3773; 0570-0833
  • Xie, Wei; Schlücker, Sebastian
    Hot electron-induced reduction of small molecules on photorecycling metal surfaces
    In: Nature Communications Vol. 6 (2015) pp. 7570
    ISSN: 2041-1723
  • Schlücker, Sebastian
    Surface-Enhanced Raman Spectroscopy : Concepts and Chemical Applications
    In: Angewandte Chemie International Edition Vol. 53 (2014) Nr. 19, pp. 4756 - 4795
    ISSN: 1521-3773; 0570-0833
  • König, Matthias; Maier, Stefan A.; Schlücker, Sebastian; Hong, Minghui; Qiu, Cheng-Wei; Giannini, Vincenzo; Roschuk, Tyler R.; Lei, Dang Yuan; Rahmani, Mohsen; Zhang, Lei
    Unveiling the Correlation between Nanometer-Thick Molecular Monolayer Sensitivity and Near-Field Enhancement and Localization in Coupled Plasmonic Oligomers
    In: ACS Nano Vol. 8 (2014) Nr. 9, pp. 9188 - 9198
    ISSN: 1936-086X; 1936-0851
  • Küstner, Bernd; Gellner, Magdalena; Schütz, Max; Schöppler, Friedrich; Marx, Alexander; Ströbel, Philipp; Adam, Patrick; Schmuck, Carsten; Schlücker, Sebastian
    SERS labels for red laser excitation: silica-encapsulated SAMs on tunable gold/silver nanoshells
    In: Angewandte Chemie International Edition Vol. 48 (2009) Nr. 11, pp. 1950 - 1953
    ISSN: 1521-3773
  • Schmuck, Carsten; Wich, Peter; Küstner, Bernd; Kiefer, Wolfgang; Schlücker, Sebastian
    Direct and label-free detection of solid-phase-bound compounds by using surface-enhanced raman scattering microspectroscopy
    In: Angewandte Chemie International Edition Vol. 46 (2007) Nr. 25, pp. 4786 - 4789
    ISSN: 1521-3773; 1433-7851; 0570-0833
  • Schlücker, Sebastian; Koster, Joachim; Singh, Ranjan K.; Asthana, Birendra P.
    Hydrogen-bonding between pyrimidine and water : A vibrational spectroscopic analysis
    In: Journal of Physical Chemistry A: Molecules, Spectroscopy, Kinetics, Environment & General Theory Vol. 111 (2007) Nr. 24, pp. 5185 - 5191
    ISSN: 1089-5639; 1520-5215
  • Koster, Joachim; Popp, Jürgen R.; Kiefer, Wolfgang; Schlücker, Sebastian
    Symmetry properties of vibrational modes in mesoporphyrin IX dimethyl ester investigated by polarization-sensitive resonance Raman and CARS spectroscopy
    In: Journal of Physical Chemistry A: Molecules, Spectroscopy, Kinetics, Environment & General Theory Vol. 110 (2006) Nr. 39, pp. 11252 - 11259
    ISSN: 1089-5639; 1520-5215