ZMB Member Thomas Schrader

ZMB Member
Thomas Schrader

Next ZMB-Member
Thomas Schrader portrait
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Prof. Dr. Thomas Schrader

Group

Biosupramolecular Chemistry

Organic Chemistry
Faculty of Chemistry
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen

Research Overview

  • Molecular tweezers and clamps for enzyme inhibition
  • Forceps and clamps against pathological protein aggregation
  • β-sheet breakers based on trimeric aminopyrazoles
  • Custom-made polymers for the detection of protein surfaces
  • Artificial signal transduction with messenger substances

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Selected Publications

    Journal articles

  • Meiners, Annika; Bäcker, Sandra; Hadrovic, Inesa; Heid, Christian; Beuck, Christine; Ruiz-Blanco, Yasser B.; Mieres-Perez, Joel; Pörschke, Marius; Grad, Jean-Noël; Vallet, Cecilia; Hoffmann, Daniel; Bayer, Peter; Sanchez-Garcia, Elsa; Schrader, Thomas; Knauer, Shirley
    Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers
    In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1505
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Guillory, Xavier; Hadrovic, Inesa; De Vink, Pim J.; Sowislok, Andrea; Brunsveld, Luc; Schrader, Thomas; Ottmann, Christian
    Supramolecular Enhancement of a Natural 14-3-3 Protein Ligand
    In: Journal of the American Chemical Society Vol. 143 (2021) Nr. 34, pp. 13495 - 13500
    ISSN: 1520-5126; 0002-7863
    Online Full Text: dx.doi.org/
  • Bengoa-Vergniory, Nora; Faggiani, Emilie; Ramos-Gonzalez, Paula; Kirkiz, Ecem; Connor-Robson, Natalie; Brown, Liam V.; Siddique, Ibrar; Li, Zizheng; Vingill, Siv; Cioroch, Milena; Cavaliere, Fabio; Threlfell, Sarah; Roberts, Bradley; Schrader, Thomas; Klärner, Frank-Gerrit; Cragg, Stephanie; Dehay, Benjamin; Bitan, Gal; Matute, Carlos; Bezard, Erwan; Wade-Martins, Richard
    CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4885
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Weil, Tatjana; Groß, Rüdiger; Röcker, Annika; Bravo-Rodriguez, Kenny; Heid, Christian; Sowislok, Andrea; Le, My-Hue; Erwin, Nelli; Dwivedi, Mridula; Bart, Stephen M.; Bates, Paul; Wettstein, Lukas; Müller, Janis A.; Harms, Mirja; Sparrer, Konstantin; Ruiz-Blanco, Yasser B.; Stürzel, Christina M.; von Einem, Jens; Lippold, Sina; Read, Clarissa; Walther, Paul; Hebel, Marco; Kreppel, Florian; Klärner, Frank-Gerrit; Bitan, Gal; Ehrmann, Michael; Weil, Tanja; Winter, Roland; Schrader, Thomas; Shorter, James; Sanchez-Garcia, Elsa; Münch, Jan
    Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers
    In: Journal of the American Chemical Society Vol. 142 (2020) Nr. 40, pp. 17024 - 17038
    ISSN: 1520-5126; 0002-7863
    Online Full Text: dx.doi.org/ (Open Access)
  • Trusch, Franziska; Loebach, Lars; Wawra, Stephan; Durward, Elaine; Wuensch, Andreas; Iberahim, Nurul Aqilah; De Bruijn, Irene; MacKenzie, Kevin; Willems, Ariane; Toloczko, Aleksandra; Diéguez-Uribeondo, Javier; Rasmussen, Tim; Schrader, Thomas; Bayer, Peter; Secombes, Chris J.; Van West, Pieter
    Cell entry of a host-targeting protein of oomycetes requires gp96
    In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 2347
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • de Vink, Pim J.; Briels, Jeroen M.; Schrader, Thomas; Milroy, Lech-Gustav; Brunsveld, Luc; Ottmann, Christian
    A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14-3-3
    In: Angewandte Chemie International Edition Vol. 56 (2017) Nr. 31, pp. 8998 - 9002
    ISSN: 1521-3773; 1433-7851
    Online Full Text: dx.doi.org/ (Open Access)
  • Hogeweg, Anna; Sowislok, Andrea; Schrader, Thomas; Beuck, Christine
    An NMR Method To Pinpoint Supramolecular Ligand Binding to Basic Residues on Proteins
    In: Angewandte Chemie International Edition Vol. 56 (2017) Nr. 46, pp. 14758 - 14762
    ISSN: 1521-3773; 1433-7851
    Online Full Text: dx.doi.org/
  • Vöpel, Tobias; Bravo-Rodriguez, Kenny; Mittal, Sumit; Vachharajani, Shivang; Gnutt, David; Sharma, Abhishek; Steinhof, Anne; Fatoba, Oluwaseun; Ellrichmann, Gisa; Nshanian, Michael; Heid, Christian; Loo, Joseph A.; Klärner, Frank-Gerrit; Schrader, Thomas; Bitan, Gal; Wanker, Erich E.; Ebbinghaus, Simon; Sanchez-Garcia, Elsa
    Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01
    In: Journal of the American Chemical Society Vol. 139 (2017) Nr. 16, pp. 5640 - 5643
    ISSN: 0002-7863; 1520-5126
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Bier, David; Mittal, Sumit; Bravo-Rodriguez, Kenny; Sowislok, Andrea; Guillory, Xavier; Briels, Jeroen; Heid, Christian; Bartel, Maria; Wettig, Burkhard; Brunsveld, Luc; Sanchez-Garcia, Elsa; Schrader, Thomas; Ottmann, Christian
    The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface
    In: Journal of the American Chemical Society Vol. 139 (2017) Nr. 45, pp. 16256 - 16263
    ISSN: 0002-7863; 1520-5126
    Online Full Text: dx.doi.org/ (Open Access)
  • Bier, David; Ottmann, Christian; Schrader, Thomas; Sanchez-Garcia, Elsa; Klärner, Frank-Gerrit; Wilch, Constanze; Dutt, Som; Ramirez-Anguita, Juan Manuel; Bartels, Maria; Bravo-Rodriguez, Kenny; Rose, Rolf
    Molecular tweezers modulate 14-3-3 protein–protein interactions
    In: Nature Chemistry Vol. 5 (2013) Nr. 3, pp. 234 - 239
    ISSN: 1755-4349; 1755-4330
    Online Full Text: dx.doi.org/
  • Peters, Max Sena; Li, Miao; Schrader, Thomas
    Interactions of calix[n]arenes with nucleic acids
    In: Nature Communications Vol. 7 (2012) Nr. 3, pp. 409 - 417
    ISSN: 2041-1723
  • Schrader, Thomas
    Protein recognition : Calixarene connection
    In: Nature Chemistry Vol. 4 (2012) Nr. 7, pp. 519 - 520
    ISSN: 1755-4349; 1755-4330
    Online Full Text: dx.doi.org/
  • Sinha, Sharmistha; Lopes, Dahabada H. J.; Du, Zhenming; Pang, Eric S.; Shanmugam, Akila; Lomakin, Aleksey; Talbiersky, Peter; Tennstaedt, Annette; McDaniel, Kirsten; Bakshi, Reena; Kuo, Pei-Yi; Ehrmann, Michael; Benedek, George B.; Loo, Joseph A.; Klärner, Frank-Gerrit; Schrader, Thomas; Wang, Chunyu; Bitan, Gal
    Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins
    In: Journal of the American Chemical Society Vol. 133 (2011) Nr. 42, pp. 16958 - 16969
    ISSN: 0002-7863; 1520-5126
    Online Full Text: dx.doi.org/
  • Hochdörffer, K.; März-Berberich, J.; Nagel-Steger, L.; Epple, Matthias; Meyer-Zaika, Wolfgang; Horn, A.H.C.; Sticht, H.; Sinha, S.; Bitan, G.; Schrader, Thomas
    Rational Design of ß-Sheet Ligands Against Aß42-Induced Toxicity
    In: Journal of the American Chemical Society Vol. 133 (2011) Nr. 12, pp. 4348 - 4358
    ISSN: 0002-7863; 1520-5126
    Online Full Text: dx.doi.org/
  • Müller-Schiffmann, Andreas; Andreyeva, Aksana; Rönicke, Raik; Bartnik, Dirk; Brener, Oleksandr; Kutzsche, Janine; Horn, Anselm H. C.; Hellmert, Marco; Polkowska, Jolanta; Gottmann, Kurt; Reymann, Klaus G.; Funke, S. Aileen; Nagel-Steger, Luitgart; Moriscot, Christine; Schoehn, Guy; Sticht, Heinrich; Willbold, Dieter; Schrader, Thomas; Korth, Carsten; März-Berberich, Julia
    Combining independent drug classes into superior, synergistically acting hybrid molecules
    In: Angewandte Chemie International Edition Vol. 49 (2010) Nr. 46, pp. 8743 - 8746
    ISSN: 1521-3773; 1433-7851; 0570-0833
    Online Full Text: dx.doi.org/
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