ZMB Member Thomas Schrader

ZMB Member
Thomas Schrader

Next ZMB-Member
Thomas Schrader portrait
© UDE

Prof. Dr. Thomas Schrader

Organic Chemistry
Faculty of Chemistry
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen

Research Overview

  • Molecular tweezers and clamps for enzyme inhibition
  • Forceps and clamps against pathological protein aggregation
  • β-sheet breakers based on trimeric aminopyrazoles
  • Custom-made polymers for the detection of protein surfaces
  • Artificial signal transduction with messenger substances

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Selected Publications

    Journal articles

  • Meiners, Annika; Bäcker, Sandra; Hadrovic, Inesa; Heid, Christian; Beuck, Christine; Ruiz-Blanco, Yasser B.; Mieres-Perez, Joel; Pörschke, Marius; Grad, Jean-Noël; Vallet, Cecilia; Hoffmann, Daniel; Bayer, Peter; Sánchez-García, Elsa; Schrader, Thomas; Knauer, Shirley
    Specific inhibition of the Survivin–CRM1 interaction by peptide-modified molecular tweezers
    In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1505
    ISSN: 2041-1723
  • Bengoa-Vergniory, Nora; Faggiani, Emilie; Ramos-Gonzalez, Paula; Kirkiz, Ecem; Connor-Robson, Natalie; Brown, Liam V.; Siddique, Ibrar; Li, Zizheng; Vingill, Siv; Cioroch, Milena; Cavaliere, Fabio; Threlfell, Sarah; Roberts, Bradley; Schrader, Thomas; Klärner, Frank-Gerrit; Cragg, Stephanie; Dehay, Benjamin; Bitan, Gal; Matute, Carlos; Bezard, Erwan; Wade-Martins, Richard
    CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4885
    ISSN: 2041-1723
  • Trusch, Franziska; Loebach, Lars; Wawra, Stephan; Durward, Elaine; Wuensch, Andreas; Iberahim, Nurul Aqilah; De Bruijn, Irene; MacKenzie, Kevin; Willems, Ariane; Toloczko, Aleksandra; Diéguez-Uribeondo, Javier; Rasmussen, Tim; Schrader, Thomas; Bayer, Peter; Secombes, Chris J.; Van West, Pieter
    Cell entry of a host-targeting protein of oomycetes requires gp96
    In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 2347
    ISSN: 2041-1723
  • de Vink, Pim J.; Briels, Jeroen M.; Schrader, Thomas; Milroy, Lech-Gustav; Brunsveld, Luc; Ottmann, Christian
    A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14-3-3
    In: Angewandte Chemie International Edition Vol. 56 (2017) Nr. 31, pp. 8998 - 9002
    ISSN: 1521-3773; 1433-7851
  • Hogeweg, Anna; Sowislok, Andrea; Schrader, Thomas; Beuck, Christine
    An NMR Method To Pinpoint Supramolecular Ligand Binding to Basic Residues on Proteins
    In: Angewandte Chemie International Edition Vol. 56 (2017) Nr. 46, pp. 14758 - 14762
    ISSN: 1521-3773; 1433-7851
  • Bier, David; Ottmann, Christian; Schrader, Thomas; Sánchez-García, Elsa; Klärner, Frank-Gerrit; Wilch, Constanze; Dutt, Som; Ramirez-Anguita, Juan Manuel; Bartels, Maria; Bravo-Rodriguez, Kenny; Rose, Rolf
    Molecular tweezers modulate 14-3-3 protein–protein interactions
    In: Nature Chemistry Vol. 5 (2013) Nr. 3, pp. 234 - 239
    ISSN: 1755-4349; 1755-4330
  • Peters, Max Sena; Li, Miao; Schrader, Thomas
    Interactions of calix[n]arenes with nucleic acids
    In: Nature Communications Vol. 7 (2012) Nr. 3, pp. 409 - 417
    ISSN: 2041-1723
  • Schrader, Thomas
    Protein recognition : Calixarene connection
    In: Nature Chemistry Vol. 4 (2012) Nr. 7, pp. 519 - 520
    ISSN: 1755-4349; 1755-4330
  • Müller-Schiffmann, Andreas; Andreyeva, Aksana; Rönicke, Raik; Bartnik, Dirk; Brener, Oleksandr; Kutzsche, Janine; Horn, Anselm H. C.; Hellmert, Marco; Polkowska, Jolanta; Gottmann, Kurt; Reymann, Klaus G.; Funke, S. Aileen; Nagel-Steger, Luitgart; Moriscot, Christine; Schoehn, Guy; Sticht, Heinrich; Willbold, Dieter; Schrader, Thomas; Korth, Carsten; März-Berberich, Julia
    Combining independent drug classes into superior, synergistically acting hybrid molecules
    In: Angewandte Chemie International Edition Vol. 49 (2010) Nr. 46, pp. 8743 - 8746
    ISSN: 1521-3773; 1433-7851; 0570-0833