ZMB Member Alexander Schramm
ZMB Member
Alexander Schramm
Next ZMB-Member
Prof. Dr. Alexander Schramm
Group
Molecular OncologyClinic for Internal Medicine (Tumor Research)
University Hospital Essen
Hufelandstraße 55
45147 Essen
- +49 201 723 1630
- Website
- Selected Publications
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- Publication Metrics
- ZMB Research Program
Oncology
Research Overview
- Mechanisms of Resistance in Lung Tumors
- Signal Transduction in Tumor Cells
- Models for Tumor Development and Progression
- Translational Immuno Oncology
- Metabolic plasticity of tumor cells
Selected Publications
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Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK PathwayIn: Cancer Research , Vol. 80 2020, Nr. 21, pp. 4655 – 4667DOI (Open Access)
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A mechanistic classification of clinical phenotypes in neuroblastomaIn: Science , Vol. 362 2018, Nr. 6419, pp. 1165 – 1170DOI (Open Access)
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Targeting MYCN-driven transcription by BET-bromodomain inhibitionIn: Clinical Cancer Research , Vol. 22 2016, Nr. 10, pp. 2470 – 2781DOI (Open Access)
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Mutational dynamics between primary and relapse neuroblastomasIn: Nature Genetics , Vol. 47 2015, Nr. 8, pp. 872 – 877
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Targeting super-enhancer induced gene expression with the novel BRD4 inhibitor OTX015 in preclinical models of MYCN-amplified neuroblastomaIn: Cancer Research , Vol. 75 2015, Nr. 15 Suppl., pp. 4731
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Telomerase activation by genomic rearrangements in high-risk neuroblastomaIn: Cancer Research , Vol. 75 2015, Nr. 15 Suppl., pp. LB – 210
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Telomerase activation by genomic rearrangements in high-risk neuroblastomaIn: Nature , Vol. 526 2015, Nr. 7575, pp. 700 – 704DOI (Open Access)
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LIN28B drives neuroblastoma oncogenesis through let7-MYCN signalingIn: Cancer Research , Vol. 73 2013, Nr. 8 Suppl. 1, pp. 4596
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LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppressionIn: Nature Genetics , Vol. 44 2012, Nr. 11, pp. 1199 – 1206
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Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiationIn: Leukemia , Vol. 26 2012, Nr. 9, pp. 2039 – 2051
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Smac mimetic LBW242 sensitizes XIAP-overexpressing neuroblastoma cells for TNF-α-independent apoptosisIn: Cancer Research , Vol. 72 2012, Nr. 10, pp. 2645 – 2656DOI (Open Access)
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Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formationIn: Nature Cell Biology , Vol. 14 2012, Nr. 9, pp. 958 – 965
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High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary NeuroblastomaIn: Clinical Cancer Research , Vol. 17 2011, Nr. 15, pp. 5082 – 5092
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Polo-like kinase 1 is a therapeutic target in high-risk neuroblastomaIn: Clinical Cancer Research , Vol. 17 2011, Nr. 4, pp. 731 – 741
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miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samplesIn: Clinical Cancer Research , Vol. 17 2011, Nr. 24, pp. 7684 – 7692
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Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signatureIn: Clinical Cancer Research , Vol. 16 2010, Nr. 5, pp. 1532 – 1541
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Chromosomal and microRNA expression patterns reveal biologically distinct subgroups of 11q- neuroblastomaIn: Clinical Cancer Research , Vol. 16 2010, Nr. 11, pp. 2971 – 2978
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Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplificationIn: Clinical Cancer Research , Vol. 16 2010, Nr. 17, pp. 4353 – 4362
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Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma : implications for therapyIn: Cancer Research , Vol. 69 2009, Nr. 5, pp. 2065 – 2071DOI (Open Access)
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Meta-mining of neuroblastoma and neuroblast gene expression profiles reveals candidate therapeutic compoundsIn: Clinical Cancer Research , Vol. 15 2009, Nr. 11, pp. 3690 – 3696
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Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cellsIn: Clinical Cancer Research , Vol. 14 2008, Nr. 4, pp. 1172 – 1181
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Fractalkine (CX3CL1)- and interleukin-2-enriched neuroblastoma microenvironment induces eradication of metastases mediated by T cells and natural killer cellsIn: Cancer Research , Vol. 67 2007, Nr. 5, pp. 2331 – 2338
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Translating expression profiling into a clinically feasible test to predict neuroblastoma outcomeIn: Clinical Cancer Research , Vol. 13 2007, Nr. 5, pp. 1459 – 1465
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Identification of a set of seven genes for the monitoring of minimal residual disease in pediatric acute myeloid leukemiaIn: Clinical Cancer Research , Vol. 12 2006, Nr. 8, pp. 2434 – 2441
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Keratoepithelin suppresses the progression of experimental human neuroblastomasIn: Cancer Research , Vol. 66 2006, Nr. 10, pp. 5314 – 5321