ZMB Member Alexander Schramm

ZMB Member
Alexander Schramm

Next ZMB-Member
Alexander Schramm portrait
© UKE/A.Schramm

Prof. Dr. Alexander Schramm

Group

Molecular Oncology

Clinic for Internal Medicine (Tumor Research)
University Hospital Essen
Hufelandstraße 55
45147 Essen

Research Overview

  • Mechanisms of Resistance in Lung Tumors
  • Signal Transduction in Tumor Cells
  • Models for Tumor Development and Progression
  • Translational Immuno Oncology
  • Metabolic plasticity of tumor cells

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Selected Publications

    Journal articles

  • Lu, Yuhong; Liu, Yanfeng; Oeck, Sebastian; Zhang, Gary J.; Schramm, Alexander; Glazer, Peter M.
    Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK Pathway
    In: Cancer Research , Vol. 80 2020, Nr. 21, pp. 4655 – 4667
    DOI (Open Access)
  • Ackermann, Sandra; Cartolano, Maria; Hero, Barbara; Welte, Anne; Kahlert, Yvonne; Roderwieser, Andrea; Bartenhagen, Christoph; Walter, Esther; Gecht, Judith; Kerschke, Laura; Volland, Ruth; Menon, Roopika; Heuckmann, Johannes M.; Gartlgruber, Moritz; Hartlieb, Sabine; Henrich, Kai-Oliver; Okonechnikov, Konstantin; Altmüller, Janine; Nürnberg, Peter; Lefever, Steve; De Wilde, Bram; Sand, Frederik; Ikram, Fakhera; Rosswog, Carolina; Fischer, Janina; Theissen, Jessica; Hertwig, Falk; Singhi, Aatur D.; Simon, Thorsten; Vogel, Wenzel; Perner, Sven; Krug, Barbara; Schmidt, Matthias; Rahmann, Sven; Achter, Viktor; Lang, Ulrich; Vokuhl, Christian; Ortmann, Monika; Büttner, Reinhard; Eggert, Angelika; Speleman, Frank; O’Sullivan, Roderick J.; Thomas, Roman K.; Berthold, Frank; Vandesompele, Jo; Schramm, Alexander; Westermann, Frank; Schulte, Johannes; Peifer, Martin; Fischer, Matthias
    A mechanistic classification of clinical phenotypes in neuroblastoma
    In: Science , Vol. 362 2018, Nr. 6419, pp. 1165 – 1170
    DOI (Open Access)
  • Henssen, Anton; Althoff, Kristina; Odersky, Andrea; Beckers, Anneleen; Koche, Richard; Speleman, Frank; Schäfers, Simon; Bell, Emma; Nortmeyer, Maike; Westermann, Frank; De Preter, Katleen; Florin, Alexandra; Heukamp, Lukas; Spruessel, Annika; Astrahanseff, Kathy; Lindner, Sven; Sadowski, Natalie; Schramm, Alexander; Astorgues-Xerri, Lucile; Riveiro, Maria E.; Eggert, Angelika; Cvitkovic, Esteban; Schulte, Johannes
    Targeting MYCN-driven transcription by BET-bromodomain inhibition
    In: Clinical Cancer Research , Vol. 22 2016, Nr. 10, pp. 2470 – 2781
    DOI (Open Access)
  • Schramm, Alexander; Köster, Johannes; Assenov, Yassen; Althoff, Kristina; Peifer, Martin; Mahlow, Ellen; Odersky, Andrea; Beisser, Daniela; Ernst, Corinna; Henssen, Anton G; Stephan, Harald; Schröder, Christopher; Heukamp, Lukas; Engesser, Anne; Kahlert, Yvonne; Theissen, Jessica; Hero, Barbara; Roels, Frederik; Altmüller, Janine; Nürnberg, Peter; Astrahantseff, Kathy; Gloeckner, Christian; De Preter, Katleen; Plass, Christoph; Lee, Sangkyun; Lode, Holger N; Henrich, Kai-Oliver; Gartlgruber, Moritz; Speleman, Frank; Schmezer, Peter; Westermann, Frank; Rahmann, Sven; Fischer, Matthias; Eggert, Angelika; Schulte, Johannes
    Mutational dynamics between primary and relapse neuroblastomas
    In: Nature Genetics , Vol. 47 2015, Nr. 8, pp. 872 – 877
    DOI
  • Spruessel, Annika; Schäfers, Simon; De Preter, Katleen; Sadowski, Natalie; Eggert, Angelika; Florin, Alexandra; Schramm, Alexander; Astorgues-Xerri, Lucile; Beckers, Anneleen; Odersky, Andrea; Heukamp, Lukas; Althoff, Kristina; Riveiro, Eugenia; Astrahanseff, Kathy; Koche, Richard; Cvitkovic, Esteban; Speleman, Frank; Henssen, Anton; Schulte, Johannes
    Targeting super-enhancer induced gene expression with the novel BRD4 inhibitor OTX015 in preclinical models of MYCN-amplified neuroblastoma
    In: Cancer Research , Vol. 75 2015, Nr. 15 Suppl., pp. 4731
    DOI
  • Kraemer, Andrea; Hertwig, Falk; Thomas, Roman K.; Buettner, Reinhard; Westermann, Frank; Perner, Sven; Fischer, Matthias; Schramm, Alexander; Menon, Roopika; Schulte, Johannes; Peifer, Martin; Roels, Frederik
    Telomerase activation by genomic rearrangements in high-risk neuroblastoma
    In: Cancer Research , Vol. 75 2015, Nr. 15 Suppl., pp. LB – 210
    DOI
  • Peifer, Martin; Hertwig, Falk; Roels, Frederik; Dreidax, Daniel; Gartlgruber, Moritz; Menon, Roopika; Krämer, Andrea; Roncaioli, Justin L; Sand, Frederik; Heuckmann, Johannes M; Ikram, Fakhera; Schmidt, Rene; Ackermann, Sandra; Engesser, Anne; Kahlert, Yvonne; Vogel, Wenzel; Altmüller, Janine; Nürnberg, Peter; Thierry-Mieg, Jean; Thierry-Mieg, Danielle; Mariappan, Aruljothi; Heynck, Stefanie; Mariotti, Erika; Henrich, Kai-Oliver; Gloeckner, Christian; Bosco, Graziella; Leuschner, Ivo; Schweiger, Michal R; Savelyeva, Larissa; Watkins, Simon C; Shao, Chunxuan; Bell, Emma; Höfer, Thomas; Achter, Viktor; Lang, Ulrich; Theissen, Jessica; Volland, Ruth; Saadati, Maral; Eggert, Angelika; de Wilde, Bram; Berthold, Frank; Peng, Zhiyu; Zhao, Chen; Shi, Leming; Ortmann, Monika; Büttner, Reinhard; Perner, Sven; Hero, Barbara; Schramm, Alexander; Schulte, Johannes; Herrmann, Carl; O'Sullivan, Roderick J; Westermann, Frank; Thomas, Roman K; Fischer, Matthias
    Telomerase activation by genomic rearrangements in high-risk neuroblastoma
    In: Nature , Vol. 526 2015, Nr. 7575, pp. 700 – 704
    DOI (Open Access)
  • Schulte, Johannes; Molenaar, J.; Lindner, S.; Schramm, Alexander; Mestdagh, P.; Speleman, F.; Versteeg, R.; Eggert, Angelika
    LIN28B drives neuroblastoma oncogenesis through let7-MYCN signaling
    In: Cancer Research , Vol. 73 2013, Nr. 8 Suppl. 1, pp. 4596
    DOI
  • Molenaar, Jan J.; Domingo-Fernández, Raquel; Ebus, Marli E.; Lindner, Sven; Koster, Jan; Drabek, Ksenija; Mestdagh, Pieter; Van Sluis, Peter; Valentijn, Linda J.; Van Nes, Johan; Broekmans, Marloes; Haneveld, Franciska; Volckmann, Richard; Bray, Isabella; Heukamp, Lukas; Sprüssel, Annika; Thor, Theresa; Kieckbusch, Kristina; Klein-Hitpaß, Ludger; Fischer, Matthias; Vandesompele, Jo; Schramm, Alexander; Van Noesel, Max M.; Varesio, Luigi; Speleman, Frank; Eggert, Angelika; Stallings, Raymond L.; Caron, Huib N.; Versteeg, Rogier; Schulte, Johannes
    LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression
    In: Nature Genetics , Vol. 44 2012, Nr. 11, pp. 1199 – 1206
    DOI
  • Sprüssel, Annika; Schulte, Johannes; Weber, Stefanie; Necke, M.; Händschke, K.; Thor, Theresa; Pajtler, Kristian; Schramm, Alexander; König, Katharina; Diehl, Linda; Mestdagh, Pieter; Vandesompele, Jo; Speleman, Frank P.; Jastrow, Holger; Heukamp, Lukas Carl; Schüle, Roland; Dührsen, Ulrich; Buettner, Reinhard H.; Eggert, Angelika; Göthert, Joachim Rudolf
    Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation
    In: Leukemia , Vol. 26 2012, Nr. 9, pp. 2039 – 2051
    DOI
  • Eschenburg, Georg; Eggert, Angelika; Schramm, Alexander; Lode, Holger N.; Hundsdoerfer, Patrick
    Smac mimetic LBW242 sensitizes XIAP-overexpressing neuroblastoma cells for TNF-α-independent apoptosis
    In: Cancer Research , Vol. 72 2012, Nr. 10, pp. 2645 – 2656
    DOI (Open Access)
  • Nittner, David; Lambertz, Irina; Clermont, Frederic; Mestdagh, Pieter; Köhler, Corinna; Nielsen, Soren Jensby; Jochemsen, Aart; Speleman, Frank; Vandesompele, Jo; Dyer, Michael A.; Schramm, Alexander; Schulte, Johannes; Marine, Jean-Christophe
    Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation
    In: Nature Cell Biology , Vol. 14 2012, Nr. 9, pp. 958 – 965
    DOI
  • Schulte, Johannes; Bachmann, Hagen Sjard; Brockmeyer, Bent; DePreter, Katleen; Oberthuer, Andre; Ackermann, Sandra; Kahlert, Yvonne; Pajtler, Kristian; Theissen, Jessica; Westermann, Frank; Vandesompele, J. o.; Speleman, Frank; Berthold, Frank; Eggert, Angelika; Brors, Benedikt; Hero, Barbara; Schramm, Alexander; Fischer, Matthias
    High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma
    In: Clinical Cancer Research , Vol. 17 2011, Nr. 15, pp. 5082 – 5092
    DOI
  • Ackermann, Sandra; Goeser, Felix; Schulte, Johannes; Schramm, Alexander; Ehemann, Felix; Hero, Barbara; Eggert, Angelika; Berthold, Frank; Fischer, Matthias
    Polo-like kinase 1 is a therapeutic target in high-risk neuroblastoma
    In: Clinical Cancer Research , Vol. 17 2011, Nr. 4, pp. 731 – 741
    DOI
  • De Preter, K.; Mestdagh, P.; Vermeulen, J.; Zeka, F.; Naranjo, A.; Bray, I.; Castel, V.; Chen, C.; Drozynska, E.; Eggert, Angelika; Hogarty, M. D.; Izycka-Swieszewska, E.; London, W. B.; Noguera, R.; Piqueras, M.; Bryan, K.; Schowe, B.; van Sluis, P.; Molenaar, J. J.; Schramm, Alexander; Schulte, Johannes; Stallings, R. L.; Versteeg, R.; Laureys, G.; Van Roy, N.; Speleman, F.; Vandesompele, J.
    miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples
    In: Clinical Cancer Research , Vol. 17 2011, Nr. 24, pp. 7684 – 7692
    DOI
  • De Preter, Katleen; Vermeulen, Joelle; Brors, Benedikt; Delattre, Olivier; Eggert, Angelika; Fischer, Matthias; Janoueix-Lerosey, Isabelle; Lavarino, Cinzia; Maris, John M.; Mora, Jaume; Nakagawara, Akira; Oberthuer, Andre; Ohira, Miki; Schleiermacher, Gudrun; Schramm, Alexander; Schulte, Johannes; Wang, Qun; Westermann, Frank; Speleman, Frank; Vandesompele, Jo
    Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signature
    In: Clinical Cancer Research , Vol. 16 2010, Nr. 5, pp. 1532 – 1541
    DOI
  • Buckley, Patrick G.; Alcock, Leah; Bryan, Kenneth; Bray, Isabella; Schulte, Johannes; Schramm, Alexander; Eggert, Angelika; Mestdagh, Pieter; De Preter, Katleen; Vandesompele, Jo; Speleman, Frank; Stallings, Raymond L.
    Chromosomal and microRNA expression patterns reveal biologically distinct subgroups of 11q- neuroblastoma
    In: Clinical Cancer Research , Vol. 16 2010, Nr. 11, pp. 2971 – 2978
    DOI
  • De Brouwer, Sara; De Preter, Katleen; Kumps, Candy; Zabrocki, Piotr; Porcu, Michael; Westerhout, Ellen M.; Lakeman, Arjan; Vandesompele, Jo; Hoebeeck, Jasmien; Van Maerken, Tom; De Paepe, Anne; Laureys, Genevieve; Schulte, Johannes; Schramm, Alexander; Van Den Broecke, Caroline; Vermeulen, Joelle; Van Roy, Nadine; Beiske, Klaus; Renard, Marleen; Noguera, Rosa; Delattre, Olivier; Janoueix-Lerosey, Isabelle; Kogner, Per; Martinsson, Tommy; Nakagawara, Akira; Ohira, Miki; Caron, Huib; Eggert, Angelika; Cools, Jan; Versteeg, Rogier; Speleman, Frank
    Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification
    In: Clinical Cancer Research , Vol. 16 2010, Nr. 17, pp. 4353 – 4362
    DOI
  • Schulte, Johannes H.; Lim, Soyoung; Schramm, Alexander; Friedrichs, Nicolaus; Koster, Jan; Versteeg, Rogier; Ora, Ingrid; Pajtler, Kristian; Klein-Hitpaß, Ludger; Kuhfittig-Kulle, Steffi; Metzger, Eric; Schüle, Roland; Eggert, Angelika; Buettner, Reinhard; Kirfel, Jutta
    Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma : implications for therapy
    In: Cancer Research , Vol. 69 2009, Nr. 5, pp. 2065 – 2071
    DOI (Open Access)
  • De Preter, Katleen; De Brouwer, Sara; Van Maerken, Tom; Pattyn, Filip; Schramm, Alexander; Eggert, Angelika; Vandesompele, Jo; Speleman, Frank
    Meta-mining of neuroblastoma and neuroblast gene expression profiles reveals candidate therapeutic compounds
    In: Clinical Cancer Research , Vol. 15 2009, Nr. 11, pp. 3690 – 3696
    DOI
  • Boller, Danielle; Schramm, Alexander; Doepfner, Kathrin T.; Shalaby, Tarek; von Bueren, Andre O.; Eggert, Angelika; Grotzer, Michael A.; Arcaro, Alexandre
    Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cells
    In: Clinical Cancer Research , Vol. 14 2008, Nr. 4, pp. 1172 – 1181
    DOI
  • Zeng, Yan; Huebener, Nicole; Fest, Stefan; Weixler, Silke; Schroeder, Ulrike; Gaedicke, Gerhard; Xiang, Rong; Schramm, Alexander; Eggert, Angelika; Reisfeld, Ralph A.; Lode, Holger N.
    Fractalkine (CX3CL1)- and interleukin-2-enriched neuroblastoma microenvironment induces eradication of metastases mediated by T cells and natural killer cells
    In: Cancer Research , Vol. 67 2007, Nr. 5, pp. 2331 – 2338
    DOI
  • Schramm, Alexander; Vandesompele, Jo; Schulte, Johannes; Dreesmann, Sabine; Kaderali, Lars; Brors, Benedikt; Eils, Roland; Speleman, Frank; Eggert, Angelika
    Translating expression profiling into a clinically feasible test to predict neuroblastoma outcome
    In: Clinical Cancer Research , Vol. 13 2007, Nr. 5, pp. 1459 – 1465
    DOI
  • Steinbach, D.; Schramm, Alexander; Eggert, Angelika; Onda, M.; Dawczynski, K.; Rump, A.; Pastan, I.; Wittig, S.; Pfaffendorf, N.; Voigt, A.; Zintl, F.; Gruhn, B.
    Identification of a set of seven genes for the monitoring of minimal residual disease in pediatric acute myeloid leukemia
    In: Clinical Cancer Research , Vol. 12 2006, Nr. 8, pp. 2434 – 2441
    DOI
  • Becker, Jürgen; Erdlenbruch, B.; Noskova, I.; Schramm, Alexander; Aumailley, M.; Schorderet, D. F.; Schweigerer, L.
    Keratoepithelin suppresses the progression of experimental human neuroblastomas
    In: Cancer Research , Vol. 66 2006, Nr. 10, pp. 5314 – 5321
    DOI
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