ZMB Member Alexander Schramm
ZMB Member
Alexander Schramm
Next ZMB-Member
Prof. Dr. Alexander Schramm
Group
Molecular OncologyClinic for Internal Medicine (Tumor Research)
University Hospital Essen
Hufelandstraße 55
45147 Essen
- +49 201 723 1630
- Website
- Selected Publications
-
- Publication Metrics
- ZMB Research Program
Oncology
Research Overview
- Mechanisms of Resistance in Lung Tumors
- Signal Transduction in Tumor Cells
- Models for Tumor Development and Progression
- Translational Immuno Oncology
- Metabolic plasticity of tumor cells
Selected Publications
-
Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK PathwayIn: Cancer Research Vol. 80 (2020) Nr. 21, pp. 4655 - 4667
ISSN: 0008-5472; 1538-7445; 0099-7013; 0099-7374Online Full Text: dx.doi.org/ -
A mechanistic classification of clinical phenotypes in neuroblastomaIn: Science Vol. 362 (2018) Nr. 6419, pp. 1165 - 1170
ISSN: 1095-9203; 0036-8075Online Full Text: dx.doi.org/ -
Targeting MYCN-driven transcription by BET-bromodomain inhibitionIn: Clinical Cancer Research Vol. 22 (2016) Nr. 10, pp. 2470 - 2781
ISSN: 1557-3265; 1078-0432Online Full Text: dx.doi.org/ (Open Access) -
Mutational dynamics between primary and relapse neuroblastomasIn: Nature Genetics Vol. 47 (2015) Nr. 8, pp. 872 - 877
ISSN: 1061-4036; 1546-1718Online Full Text: dx.doi.org/ -
Targeting super-enhancer induced gene expression with the novel BRD4 inhibitor OTX015 in preclinical models of MYCN-amplified neuroblastomaIn: Cancer Research Vol. 75 (2015) Nr. 15 Suppl., pp. 4731
ISSN: 0008-5472; 0008-5472Online Full Text: dx.doi.org/ -
Telomerase activation by genomic rearrangements in high-risk neuroblastomaIn: Cancer Research Vol. 75 (2015) Nr. 15 Suppl., pp. LB - 210
ISSN: 0008-5472Online Full Text: dx.doi.org/ -
Telomerase activation by genomic rearrangements in high-risk neuroblastomaIn: Nature Vol. 526 (2015) Nr. 7575, pp. 700 - 704
ISSN: 0028-0836; 1476-4687Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
LIN28B drives neuroblastoma oncogenesis through let7-MYCN signalingIn: Cancer Research Vol. 73 (2013) Nr. 8 Suppl. 1, pp. 4596
ISSN: 0008-5472; 1538-7445; 0099-7013; 0099-7374Online Full Text: dx.doi.org/ -
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppressionIn: Nature Genetics Vol. 44 (2012) Nr. 11, pp. 1199 - 1206
ISSN: 1061-4036; 1546-1718Online Full Text: dx.doi.org/ -
Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiationIn: Leukemia Vol. 26 (2012) Nr. 9, pp. 2039 - 2051
ISSN: 0887-6924; 1476-5551Online Full Text: dx.doi.org/ -
Smac mimetic LBW242 sensitizes XIAP-overexpressing neuroblastoma cells for TNF-α-independent apoptosisIn: Cancer Research Vol. 72 (2012) Nr. 10, pp. 2645 - 2656
ISSN: 0008-5472; 1538-7445; 0099-7013; 0099-7374Online Full Text: dx.doi.org/ (Open Access) -
Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formationIn: Nature Cell Biology Vol. 14 (2012) Nr. 9, pp. 958 - 965
ISSN: 1465-7392; 1476-4679Online Full Text: dx.doi.org/ -
High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary NeuroblastomaIn: Clinical Cancer Research Vol. 17 (2011) Nr. 15, pp. 5082 - 5092
ISSN: 1078-0432; 1557-3265Online Full Text: dx.doi.org/ -
Polo-like kinase 1 is a therapeutic target in high-risk neuroblastomaIn: Clinical Cancer Research Vol. 17 (2011) Nr. 4, pp. 731 - 741
ISSN: 1078-0432; 1557-3265Online Full Text: dx.doi.org/ -
miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samplesIn: Clinical Cancer Research Vol. 17 (2011) Nr. 24, pp. 7684 - 7692
ISSN: 1078-0432; 1557-3265Online Full Text: dx.doi.org/ -
Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signatureIn: Clinical Cancer Research Vol. 16 (2010) Nr. 5, pp. 1532 - 1541
ISSN: 1078-0432; 1557-3265Online Full Text: dx.doi.org/ -
Chromosomal and microRNA expression patterns reveal biologically distinct subgroups of 11q- neuroblastomaIn: Clinical Cancer Research Vol. 16 (2010) Nr. 11, pp. 2971 - 2978
ISSN: 1078-0432; 1557-3265Online Full Text: dx.doi.org/ -
Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplificationIn: Clinical Cancer Research Vol. 16 (2010) Nr. 17, pp. 4353 - 4362
ISSN: 1078-0432; 1557-3265Online Full Text: dx.doi.org/ -
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma : implications for therapyIn: Cancer Research Vol. 69 (2009) Nr. 5, pp. 2065 - 2071
ISSN: 0008-5472; 1538-7445; 0099-7013; 0099-7374Online Full Text: dx.doi.org/ (Open Access) -
Meta-mining of neuroblastoma and neuroblast gene expression profiles reveals candidate therapeutic compoundsIn: Clinical Cancer Research Vol. 15 (2009) Nr. 11, pp. 3690 - 3696
ISSN: 1078-0432; 1557-3265Online Full Text: dx.doi.org/ -
Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cellsIn: Clinical Cancer Research Vol. 14 (2008) Nr. 4, pp. 1172 - 1181
ISSN: 1078-0432; 1557-3265Online Full Text: dx.doi.org/