ZMB Member Andrea Musacchio

ZMB Member
Andrea Musacchio

Next ZMB-Member
portrait photo of ZMB member Andrea Musacchio
© MPI/Musacchio

Prof. Dr. Andrea Musacchio

Group

Mechanistic Cell Biology

Max Planck Institute of Molecular Physiology
Otto-Hahn-Staße 11
44227 Dortmund

Research Overview

  • Spindle assembly checkpoint components and functions
  • Spindle assembly checkpoint (SAC) signalling
  • Mitotic checkpoint complex (MCC)
  • Anaphase-promoting complex (APC/C)
  • Structural organization of the kinetochore
  • Analyses of localization dependencies of kinetochore proteins
  • Kinetochore receptors of checkpoint components
  • Kinetochore–microtubule attachment
  • Homeostatic control of mitotic arrest
  • Sensitivity of cancer cells to antitubulin chemotherapeutics

Read more

Selected Publications

    2025

  • Esposito-Verza, Arianna; Musacchio, Andrea; Conti, Duccio
    Decoding the language of PLK1 docking motifs and activation mechanisms
    In: Trends in Cell Biology, 2025, in press
    DOI (Open Access)
  • Mueller, Franziska; Bischoff, Matthias; Gentz, Sascha; Musacchio, Andrea; Sievers, Sonja; Bange, Tanja
    A fluorescent CPM-based in vitro acetylation assay : A tool for assessing N-terminal acetyltransferase activity and profiling compound activity
    In: Methods in Enzymology, Vol. 718, 2025, pp. 51 – 85
    DOI
  • Schweighofer, Julia; Mulay, Bhagyashree; Hoffmann, Ingrid; Vogt, Doro; Pesenti, Marion E.; Musacchio, Andrea
    Interactions with multiple inner kinetochore proteins determine mitotic localization of FACT
    In: The Journal of Cell Biology (JCB), Vol. 224, 2025, Nr. 5, e202412042
    DOI (Open Access)
  • Sethi, Suruchi; Ghetti, Sabrina; Cmentowski, Verena; Guerriere, Teresa Benedetta; Stege, Patricia; Piano, Valentina; Musacchio, Andrea
    Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complex
    In: Nature Communications, Vol. 16, 2025, Nr. 1, 4823
    DOI (Open Access)
  • Cmentowski, Verena; Musacchio, Andrea
    The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona
    In: Science Advances, Vol. 11, 2025, Nr. 37, eady6890
    DOI (Open Access)

    • 2024

  • Conti, Duccio; Verza, Arianna Esposito; Pesenti, Marion E.; Cmentowski, Verena; Vetter, Ingrid R.; Pan, Dongqing; Musacchio, Andrea
    Role of protein kinase PLK1 in the epigenetic maintenance of centromeres
    In: Science, Vol. 385, 2024, Nr. 6713, pp. 1091 – 1097
    DOI
  • Lim, Wei Ming; Chew, Wei-Xiang; Esposito Verza, Arianna; Pesenti, Marion; Musacchio, Andrea; Surrey, Thomas
    Regulation of minimal spindle midzone organization by mitotic kinases
    In: Nature Communications, Vol. 15, 2024, Nr. 1, 9213
    DOI (Open Access)
  • Pleuger, Richard; Cozma, Christian; Hohoff, Simone; Denkhaus, Christian; Dudziak, Alexander; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Vetter, Ingrid R.; Westermann, Stefan
    Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptor
    In: Current Biology, Vol. 34, 2024, Nr. 11, pp. 2279 – 2293.e6
    DOI (Open Access)
  • Hedtfeld, Marius; Musacchio, Andrea
    Protocol for validating liquid-liquid phase separation as a driver of membraneless organelle assembly in vitro and human cells
    In: STAR Protocols, Vol. 5, 2024, Nr. 4, 103410
    DOI (Open Access)
  • Hedtfeld, Marius; Dammers, Alicia; Koerner, Carolin; Musacchio, Andrea
    A validation strategy to assess the role of phase separation as a determinant of macromolecular localization
    In: Molecular Cell, Vol. 84, 2024, Nr. 9, pp. 1783 – 1801.e7
    DOI (Open Access)
  • Polley, Soumitra; Raisch, Tobias; Ghetti, Sabrina; Körner, Marie; Terbeck, Melina; Gräter, Frauke; Raunser, Stefan; Aponte-Santamaría, Camilo; Vetter, Ingrid R.; Musacchio, Andrea
    Structure of the human KMN complex and implications for regulation of its assembly
    In: Nature Structural & Molecular Biology, Vol. 31, 2024, Nr. 6, pp. 861 – 873
    DOI (Open Access)
  • Musacchio, Andrea
    Thirty years of structural changes
    In: Nature Structural & Molecular Biology, Vol. 31, 2024, Nr. 1, pp. 4 – 5
    DOI

    • 2023

  • Pleuger, Richard; Cozma, Christian; Hohoff, Simone; Denkhaus, Christian; Dudziak, Alexander; Kaschani, Farnusch; Musacchio, Andrea; Vetter, Ingrid R.; Westermann, Stefan
    Ipl1-controlled attachment maturation regulates Mps1 association with its kinetochore receptor
    2023
    DOI (Open Access)
  • Cmentowski, Verena; Ciossani, Giuseppe; d'Amico, Ennio; Wohlgemuth, Sabine; Owa, Mikito; Dynlacht, Brian; Musacchio, Andrea
    RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona
    In: The EMBO Journal, Vol. 42, 2023, Nr. 24, e114838
    DOI (Open Access)
  • Chen, Chu; Piano, Valentina; Alex, Amal; Han, Simon J Y; Huis In 't Veld, Pim J.; Roy, Babhrubahan; Fergle, Daniel; Musacchio, Andrea; Joglekar, Ajit P.; Huis in ’t Veld, Pim J.
    The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint Complex
    In: Nature Communications, Vol. 14, 2023, Nr. 1, 1529
    DOI (Open Access)
  • Polley, Soumitra; Müschenborn, Helen; Terbeck, Melina; De Antoni, Anna; Vetter, Ingrid R; Dogterom, Marileen; Musacchio, Andrea; Volkov, Vladimir A; Huis in 't Veld, Pim J
    Stable kinetochore-microtubule attachment requires loop-dependent Ndc80-Ndc80 binding
    In: The EMBO Journal, Vol. 42, 2023, Nr. 13, e112504
    DOI (Open Access)

    • 2022

  • d'Amico, Ennio A.; Ud Din Ahmad, Misbha; Cmentowski, Verena; Girbig, Mathias; Müller, Franziska; Wohlgemuth, Sabine; Brockmeyer, Andreas; Maffini, Stefano; Janning, Petra; Vetter, Ingrid R.; Carter, Andrew P.; Perrakis, Anastassis; Musacchio, Andrea
    Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin
    In: The Journal of Cell Biology (JCB), Vol. 221, 2022, Nr. 11, e202206131
    DOI (Open Access)
  • Celestino, Ricardo; Gama, José B; Castro-Rodrigues, Artur F.; Barbosa, Daniel J.; Rocha, Helder; d'Amico, Ennio A.; Musacchio, Andrea; Carvalho, Ana Xavier; Morais-Cabral, João H; Gassmann, Reto; d’Amico, Ennio A.
    JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport
    In: The Journal of Cell Biology (JCB), Vol. 221, 2022, Nr. 8, e202110057
    DOI (Open Access)
  • Huis in 't Veld, Pim J.; Wohlgemuth, Sabine; Koerner, Carolin; Müller, Franziska; Janning, Petra; Musacchio, Andrea
    Reconstitution and use of highly active human CDK1 : Cyclin-B:CKS1 complexes
    In: Protein Science, Vol. 31, 2022, Nr. 2, pp. 528 – 537
    DOI (Open Access)
  • Pesenti, Marion E.; Raisch, Tobias; Conti, Duccio; Walstein, Kai; Hoffmann, Ingrid; Vogt, Dorothee; Prumbaum, Daniel; Vetter, Ingrid R.; Raunser, Stefan; Musacchio, Andrea
    Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization
    In: Molecular Cell, Vol. 82, 2022, Nr. 11, pp. 2113 – 2131.e8
    DOI (Open Access)
  • Raisch, Tobias; Ciossani, Giuseppe; d’Amico, Ennio; Cmentowski, Verena; Carmignani, Sara; Maffini, Stefano; Merino, Felipe; Wohlgemuth, Sabine; Vetter, Ingrid R.; Raunser, Stefan; Musacchio, Andrea
    Structure of the RZZ complex and molecular basis of Spindly‐driven corona assembly at human kinetochores
    In: The EMBO Journal, Vol. 41, 2022, Nr. 9, e110411
    DOI, Online Full Text (Open Access)
  • Musacchio, Andrea
    On the role of phase separation in the biogenesis of membraneless compartments
    In: The EMBO Journal, Vol. 41, 2022, Nr. 5, e109952
    DOI (Open Access)
  • Martin, Isabel M.; Aponte-Santamaría, Camilo; Schmidt, Lisa; Hedtfeld, Marius; Iusupov, Adel; Musacchio, Andrea; Gräter, Frauke
    Phosphorylation tunes elongation propensity and cohesiveness of INCENP's intrinsically disordered region : Phosphorylation of INCENP disordered region
    In: Journal of Molecular Biology (JMB), Vol. 434, 2022, Nr. 1, 167387
    DOI

    • 2021

  • Walstein, Kai; Petrovic, Arsen; Pan, Dongqing; Hagemeier, Birte; Vogt, Dorothee; Vetter, Ingrid R.; Musacchio, Andrea
    Assembly principles and stoichiometry of a complete human kinetochore module
    In: Science Advances, Vol. 7, 2021, Nr. 27, eabg1037
    DOI (Open Access)
  • Piano, Valentina; Alex, Amal; Stege, Patricia; Maffini, Stefano; Stoppiello, Gerardo A.; Huis In'T Veld, Pim J.; Vetter, Ingrid R.; Musacchio, Andrea
    CDC20 assists its catalytic incorporation in the mitotic checkpoint complex
    In: Science, Vol. 371, 2021, Nr. 6524, pp. 67 – 71
    DOI
  • Mueller, Franziska; Friese, Alexandra; Pathe, Claudio; da Silva, Richard Cardoso; Bravo Rodriguez, Kenny; Musacchio, Andrea; Bange, Tanja
    Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilization
    In: Science Advances, Vol. 7, 2021, Nr. 3, pp. eabc8590
    DOI (Open Access)
  • Singh, Priyanka; Pesenti, Marion E.; Maffini, Stefano; Carmignani, Sara; Hedtfeld, Marius; Petrovic, Arsen; Srinivasamani, Anupallavi; Bange, Tanja; Musacchio, Andrea
    BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis
    In: Molecular Cell, Vol. 81, 2021, Nr. 1, pp. 67 – 87.e9
    DOI (Open Access)
  • van den Boom, Johannes; Kück, Anja; Kravic, Bojana; Müschenborn, Helen; Giesing, Maike; Pan, Dongqing; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Meyer, Hemmo
    Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly
    In: Nature Structural & Molecular Biology, Vol. 28, 2021, Nr. 12, pp. 964 – 971
    DOI

    • 2019

  • Huis In 't Veld, Pim J.; Volkov, Vladimir A.; Stender, Isabelle D.; Musacchio, Andrea; Dogterom, Marileen
    Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling
    In: eLife, Vol. 8, 2019, pp. e49539
    DOI (Open Access)
  • Pan, Dongqing; Walstein, Kai; Take, Annika; Bier, David; Kaiser, Nadine; Musacchio, Andrea
    Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing
    In: Nature Communications, Vol. 10, 2019, Nr. 1, pp. 4046
    DOI (Open Access)
  • Alex, Amal; Piano, Valentina; Polley, Soumitra; Stuiver, Marchel; Voss, Stephanie; Ciossani, Giuseppe; Overlack, Katharina; Voss, Beate; Wohlgemuth, Sabine; Petrovic, Arsen; Wu, Yaowen; Selenko, Philipp; Musacchio, Andrea; Maffini, Stefano
    Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology
    In: eLife, Vol. 8, 2019, pp. e48287
    DOI (Open Access)

    • 2018

  • Pesenti, Marion E; Prumbaum, Daniel; Auckland, Philip; Smith, Charlotte M; Faesen, Alex C; Petrovic, Arsen; Erent, Muriel; Maffini, Stefano; Pentakota, Satyakrishna; Weir, John R; Lin, Yu-Chih; Raunser, Stefan; McAinsh, Andrew D; Musacchio, Andrea
    Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80.
    In: Molecular Cell, Vol. 71, 2018, Nr. 6, pp. 923 – 939.e10
    DOI (Open Access)
  • Weith, Matthias; Seiler, Jonas; van den Boom, Johannes; Kracht, Matthias; Hülsmann, Julia; Primorac, Ivana; Del Pino Garcia, Javier; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Bollen, Mathieu; Meyer, Hemmo
    Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation
    In: Molecular Cell, Vol. 72, 2018, Nr. 4, pp. 766 – 777
    DOI (Open Access)
  • Ciossani, Giuseppe; Overlack, Katharina; Petrovic, Arsen; Huis In 'T Veld, Pim J.; Koerner, Carolin; Wohlgemuth, Sabine; Maffini, Stefano; Musacchio, Andrea
    The kinetochore proteins CENP-E and CENP-F directly and specifically interact with distinct BUB mitotic checkpoint Ser/Thr kinases
    In: The Journal of Biological Chemistry (JBC), Vol. 293, 2018, Nr. 26, pp. 10084 – 10101
    DOI (Open Access)
  • Sacristan, Carlos; Ahmad, Misbha Ud Din; Keller, Jenny; Fermie, Job; Groenewold, Vincent; Tromer, Eelco; Fish, Alexander; Melero, Roberto; Carazo, José María; Klumperman, Judith; Musacchio, Andrea; Perrakis, Anastassis; Kops, Geert JPL
    Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis
    In: Nature Cell Biology, Vol. 20, 2018, pp. 800 – 810
    DOI, Online Full Text (Open Access)
  • Pan, Dongqing; Brockmeyer, Andreas; Mueller, Franziska; Musacchio, Andrea; Bange, Tanja
    Simplified Protocol for Cross-linking Mass Spectrometry Using the MS-Cleavable Cross-linker DSBU with Efficient Cross-link Identification
    In: Analytical Chemistry, Vol. 90, 2018, Nr. 18, pp. 10990 – 10999
    DOI

    • 2017

  • Faesen, Alex C.; Thanasoula, Maria; Maffini, Stefano; Breit, Claudia; Müller, Franziska; Van Gerwen, Suzan; Bange, Tanja; Musacchio, Andrea
    Basis of catalytic assembly of the mitotic checkpoint complex
    In: Nature, Vol. 542, 2017, Nr. 7642, pp. 498 – 502
    DOI, Online Full Text (Open Access)
  • Overlack, Katharina; Bange, Tanja; Weissmann, Florian; Faesen, Alex C.; Maffini, Stefano; Primorac, Ivana; Müller, Franziska; Peters, Jan-Michael; Musacchio, Andrea
    BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling
    In: Current Biology, Vol. 27, 2017, Nr. 19, pp. 2915 – 2927.e7
    DOI (Open Access)
  • Pan, Dongqing; Klare, Kerstin; Petrovic, Arsen; Take, Annika; Walstein, Kai; Singh, Priyanka; Rondelet, Arnaud; Bird, Alexander W; Musacchio, Andrea
    CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading
    In: eLife, Vol. 6, 2017, pp. e23352
    DOI, Online Full Text (Open Access)
  • Pentakota, Satyakrishna; Zhou, Keda; Smith, Charlotte; Maffini, Stefano; Petrovic, Arsen; Morgan, Garry P.; Weir, John R.; Vetter, Ingrid R.; Musacchio, Andrea; Luger, Karolin
    Decoding the centromeric nucleosome through CENP-N
    In: eLife, Vol. 6, 2017, pp. e33442
    DOI (Open Access)
  • Musacchio, Andrea; Desai, Arshad
    A molecular view of kinetochore assembly and function
    In: Biology, Vol. 6, 2017, Nr. 1, pp. 5
    DOI (Open Access)
  • Mosalaganti, Shyamal; Keller, Jenny; Altenfeld, Anika; Winzker, Michael; Rombaut, Pascaline; Saur, Michael; Petrovic, Arsen; Wehenke, Annemarie; Wohlgemuth, Sabine; Müller, Franziska; Maffini, Stefano; Bange, Tanja; Herzog, Franz; Waldmann, Herbert; Raunser, Stefan; Musacchio, Andrea
    Structure of the RZZ complex and molecular basis of its interaction with Spindly
    In: The Journal of Cell Biology (JCB), Vol. 216, 2017, Nr. 4, pp. 961 – 981
    DOI (Open Access)
  • Vader, Gerben; Musacchio, Andrea
    The greatest kinetochore show on earth
    In: EMBO Reports, Vol. 18, 2017, Nr. 9, pp. 1473 – 1475
    DOI, Online Full Text (Open Access)

    • 2016

  • Pesenti, Marion E.; Weir, John R.; Musacchio, Andrea
    Progress in the structural and functional characterization of kinetochores
    In: Current Opinion in Structural Biology, Vol. 37, 2016, pp. 152 – 163
    DOI (Open Access)
  • O'Connor, Aisling; Maffini, Stefano; Rainey, Michael D.; Kaczmarczyk, Agnieszka; Gaboriau, David; Musacchio, Andrea; Santocanale, Corrado
    Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint
    In: Biology Open: BiO, Vol. 5, 2016, Nr. 1, pp. 11 – 19
    DOI (Open Access)
  • Weir, John R.; Faesen, Alex C.; Klare, Kerstin; Petrovic, Arsen; Basilico, Federica; Fischböck, Josef; Pentakota, Satyakrishna; Keller, Jenny; Pesenti, Marion E.; Pan, Dongqing; Vogt, Doro; Wohlgemuth, Sabine; Herzog, Franz; Musacchio, Andrea
    Insights from biochemical reconstitution into the architecture of human kinetochores
    In: Nature, Vol. 537, 2016, Nr. 7619, pp. 249 – 253
    DOI
  • Huisin’T Veld, Pim J.; Jeganathan, Sadasivam; Petrovic, Arsen; Singh, Priyanka; John, Juliane; Krenn, Veronica; Weissmann, Florian; Bange, Tanja; Musacchio, Andrea
    Molecular basis of outer kinetochore assembly on CENP-T
    In: eLife, Vol. 5, 2016, pp. e21007
    DOI (Open Access)
  • Liu, Yahui; Petrovic, Arsen; Rombaut, Pascaline; Mosalaganti, Shyamal; Keller, Jenny; Raunser, Stefan; Herzog, Franz; Musacchio, Andrea
    Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster
    In: Open Biology, Vol. 6, 2016, Nr. 2, 150236
    DOI (Open Access)
  • Friese, Alexandra; Musacchio, Andrea; Herzog, Franz; Raunser, Stefan; Petrovic, Arsen; Prumbaum, Daniel; Fischböck, Josef; Huis in ‘t Veld,, Pim J.; Faesen, Alex C.
    Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin
    In: Nature Communications, Vol. 7, 2016, pp. 11407
    DOI (Open Access)
  • Petrovic, Arsen; Keller, Jenny; Liu, Yahui; Overlack, Katharina; John, Juliane; Dimitrova, Yoana N.; Jenni, Simon; van Gerwen, Suzan; Stege, Patricia; Wohlgemuth, Sabine; Rombaut, Pascaline; Herzog, Franz; Harrison, Stephen C.; Vetter, Ingrid R.; Musacchio, Andrea
    Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores
    In: Cell, Vol. 167, 2016, Nr. 4, pp. 1028 – 1040.e15
    DOI (Open Access)
  • Borisy, Gary; Musacchio, Andrea; Janke, Carsten; Howard, Jonathon; Heald, Rebecca; Nogales, Eva
    Microtubules : 50 years on from the discovery of tubulin
    In: Nature Reviews Molecular Cell Biology, Vol. 17, 2016, Nr. 5, pp. 322 – 328
    DOI, Online Full Text (Open Access)

    • 2015

  • Musacchio, Andrea
    The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics
    In: Current Biology, Vol. 25, 2015, Nr. 20, pp. R1002 – R1018
    DOI (Open Access)
  • Breit, Claudia; Bange, Tanja; Petrović, Arsen N.; Weir, John R.; Müller, Franziska; Vogt, Doro; Musacchio, Andrea
    Role of intrinsic and extrinsic factors in the regulation of the mitotic checkpoint kinase Bub1
    In: PLoS ONE, Vol. 10, 2015, Nr. 12, pp. 0144673
    DOI (Open Access)
  • Krenn, Veronica; Musacchio, Andrea
    The Aurora B kinase in chromosome bi-orientation and spindle checkpoint signaling
    In: Frontiers in Oncology, Vol. 5, 2015, pp. 225
    DOI (Open Access)
  • Overlack, Katharina; Primorac, Ivana; Vleugel, Mathijs; Krenn, Veronica; Maffini, Stefano; Hoffmann, Ingrid; Kops, Geert J. P. L.; Musacchio, Andrea
    A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint
    In: eLife, Vol. 4, 2015, pp. e05269
    DOI (Open Access)
  • Klare, Kerstin; Weir, John R.; Basilico, Federica; Zimniak, Tomasz; Massimiliano, Lucia; Ludwigs, Nina; Herzog, Franz; Musacchio, Andrea
    CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochores
    In: The Journal of Cell Biology (JCB), Vol. 210, 2015, Nr. 1, pp. 11 – 22
    DOI (Open Access)
  • Musacchio, Andrea
    Closing the Mad2 cycle : chromosome separation is regulated by a cycle that involves a protein undergoing an unusual topological conversion
    In: eLife, Vol. 4, 2015, pp. e08283
    DOI (Open Access)
  • Meyer, Rebecca; Faesen, Alex; Vogel, Katrin; Jeganathan, Sadasivam; Musacchio, Andrea; Niemeyer, Christof M.
    DNA-directed assembly of capture tools for constitutional studies of large protein complexes
    In: Small, Vol. 11, 2015, Nr. 22, pp. 2669 – 2674
    DOI
  • Altenfeld, Anika; Wohlgemuth, Sabine; Wehenkel, Annemarie; Vetter, Ingrid R.; Musacchio, Andrea
    Complex assembly, crystallization and preliminary x-ray crystallographic analysis of the human Rod-Zwilch-ZW10 (RZZ) complex
    In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications, Vol. 71, 2015, Nr. 4, pp. 438 – 442
    DOI (Open Access)
  • Faesen, Alex C.; Musacchio, Andrea
    The (phospho) needle in the (MELT) haystack
    In: Molecular Cell, Vol. 57, 2015, Nr. 5, pp. 765 – 766
    DOI (Open Access)
  • Tachiwana, Hiroaki; Müller, Sebastian; Blümer, Julia; Klare, Kerstin; Musacchio, Andrea; Almouzni, Geneviève
    HJURP involvement in De Novo CenH3CENP-A and CENP-C recruitment
    In: Cell Reports, Vol. 11, 2015, Nr. 1, pp. 22 – 32
    DOI (Open Access)

    • 2014

  • Vader, Gerben; Musacchio, Andrea
    HORMA domains at the heart of meiotic chromosome dynamics
    In: Developmental Cell, Vol. 31, 2014, Nr. 4, pp. 389 – 391
    DOI (Open Access)
  • Eiteneuer, Annika; Seiler, Jonas; Weith, Matthias; Beullens, Monique; Lesage, Bart; Krenn, Veronica; Musacchio, Andrea; Bollen, Mathieu; Meyer, Hemmo
    Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1
    In: The EMBO Journal, Vol. 33, 2014, Nr. 22, pp. 2704 – 2720
    DOI, Online Full Text (Open Access)
  • Petrovic, Arsen; Mosalaganti, Shyamal; Keller, Jenny; Mattiuzzo, Marta; Overlack, Katharina; Krenn, Veronica; De Antoni, Anna; Wohlgemuth, Sabine; Cecatiello, Valentina; Pasqualato, Sebastiano; Raunser, Stefan; Musacchio, Andrea
    Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore Organization
    In: Molecular Cell, Vol. 53, 2014, Nr. 4, pp. 591 – 605
    DOI (Open Access)
  • Krenn, Veronica; Overlack, Katharina; Primorac, Ivana; Van Gerwen, Suzan; Musacchio, Andrea
    KI motifs of human Knl1 enhance assembly of comprehensive spindle checkpoint complexes around MELT repeats
    In: Current Biology, Vol. 24, 2014, Nr. 1, pp. 29 – 39
    DOI (Open Access)
  • Overlack, Katharina; Krenn, Veronica; Musacchio, Andrea
    When Mad met Bub
    In: EMBO Reports, Vol. 15, 2014, Nr. 4, pp. 326 – 328
    DOI, Online Full Text (Open Access)
  • Basilico, Federica; Maffini, Stefano; Weir, John R.; Prumbaum, Daniel; Rojas, Ana M.; Zimniak, Tomasz; De Antoni, Anna; Jeganathan, Sadasivam; Voss, Beate; Van Gerwen, Suzan; Krenn, Veronica; Massimiliano, Lucia; Valencia, Alfonso; Vetter, Ingrid R.; Herzog, Franz; Raunser, Stefan; Pasqualato, Sebastiano; Musacchio, Andrea
    The pseudo GTPase CENP-M drives human kinetochore assembly
    In: eLife, Vol. 3, 2014, pp. e02978
    DOI (Open Access)

    • 2013

  • Earnshaw, William C.; Allshire, Robin C.; Black, Ben E.; Bloom, Kerry; Brinkley, Bill R.; Brown, William; Cheeseman, Iain M.; Choo, Kong H. A.; Copenhaver, Gregory P.; DeLuca, Jennifer G.; Desai, Arshad; Diekmann, Stephan; Erhardt, Sylvia; Fitzgerald-Hayes, Molly; Foltz, Daniel; Fukagawa, Tatsuo; Gassmann, Reto; Gerlich, Daniel W.; Glover, David M.; Gorbsky, Gary J.; Harrison, Stephen C.; Heun, Patrick; Hirota, Toru; Jansen, Lars E. T.; Karpen, Gary; Kops, Geert J. P. L.; Lampson, Michael A.; Lens, Susanne M.; Losada, Ana; Luger, Karolin; Maiato, Helder; Maddox, Paul S.; Margolis, Robert L.; Masumoto, Hiroshi; McAinsh, Andrew D.; Mellone, Barbara G.; Meraldi, Patrick; Musacchio, Andrea; Oegema, Karen; O'Neill, Rachel J.; Salmon, Edward D.; Scott, Kristin C.; Straight, Aaron F.; Stukenberg, Peter T.; Sullivan, Beth A.; Sullivan, Kevin F.; Sunkel, Claudio E.; Swedlow, Jason R.; Walczak, Claire E.; Warburton, Peter E.; Westermann, Stefan; Willard, Huntington F.; Wordeman, Linda; Yanagida, Mitsuhiro; Yen, Tim J.; Yoda, Kinya; Cleveland, Don W.
    Esperanto for histones : CENP-A, not CenH3, is the centromeric histone H3 variant
    In: Chromosome Research, Vol. 21, 2013, Nr. 2, pp. 101 – 106
    DOI
  • Musacchio, Andrea; Ciliberto, Andrea
    The spindle-assembly checkpoint and the beauty of self-destruction : Erratum
    In: Nature Structural & Molecular Biology, Vol. 20, 2013, Nr. 2, pp. 244
    DOI
  • Primorac, Ivana; Weir, John R.; Chiroli, Elena; Gross, Fridolin; Hoffmann, Ingrid; Van Gerwen, Suzan; Ciliberto, Andrea; Musacchio, Andrea
    Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling
    In: eLife, Vol. 2, 2013, pp. e01030
    DOI (Open Access)
  • Musacchio, Andrea; Helin, Kristian
    Cell cycle, differentiation and disease : editorial overview
    In: Current Opinion in Cell Biology. Amsterdam: Elsevier, Vol. 25, 2013, Nr. 6, pp. 673 – 675
    DOI
  • Primorac, Ivana; Musacchio, Andrea
    Panta rhei : the APC/C at steady state
    In: The Journal of Cell Biology (JCB), Vol. 201, 2013, Nr. 2, pp. 177 – 189
    DOI
  • Hagemann, S.; Wohlschläger, Jeremias; Bertram, S.; Levkau, Bodo; Musacchio, Andrea; Conway, E. M.; Möllmann, D.; Kneiseler, G.; Pless-Petig, G.; Lorenz, Kristina; Sitek, B.; Baba, Hideo Andreas
    Loss of survivin influences liver regeneration and is associated with impaired aurora B function
    In: Cell Death and Differentiation, Vol. 20, 2013, Nr. 6, pp. 834 – 844
    DOI

    • 2012

  • Musacchio, Andrea
    Q & A : Andrea Musacchio
    In: Current Biology, Vol. 22, 2012, Nr. 14, pp. R552 – R554
    DOI
  • Kwiatkowski, Nicholas; Deng, Xianming; Wang, Jinhua; Tan, Li; Villa, Fabrizio; Santaguida, Stefano; Huang, Hsiao-Chun; Mitchison, Tim; Musacchio, Andrea; Gray, Nathanael
    Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen
    In: ACS Chemical Biology, Vol. 7, 2012, Nr. 1, pp. 185 – 196
    DOI
  • DeLuca, Jennifer G.; Musacchio, Andrea
    Structural organization of the kinetochore-microtubule interface
    In: Current Opinion in Cell Biology, Vol. 24, 2012, Nr. 1, pp. 48 – 56
    DOI
  • De Antoni, Anna; Maffini, Stefano; Knapp, Stefan; Musacchio, Andrea; Santaguida, Stefano
    A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
    In: The Journal of Cell Biology (JCB), Vol. 199, 2012, Nr. 2, pp. 269 – 284
    DOI
  • Musacchio, Andrea; Ciliberto, Andrea
    The spindle-assembly checkpoint and the beauty of self-destruction
    In: Nature Structural & Molecular Biology, Vol. 19, 2012, Nr. 11, pp. 1059 – 1061
    DOI
  • Krenn, Veronica; Wehenkel, Annemarie; Li, Xiaozheng; Santaguida, Stefano; Musacchio, Andrea
    Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction
    In: The Journal of Cell Biology (JCB), Vol. 196, 2012, Nr. 4, pp. 451 – 467
    DOI
  • Elkins, Jonathan M.; Santaguida, Stefano; Musacchio, Andrea; Knapp, Stefan
    Crystal structure of human Aurora B in complex with INCENP and VX-680
    In: Journal of Medicinal Chemistry, Vol. 55, 2012, Nr. 17, pp. 7841 – 7848
    DOI (Open Access)
  • Mariani, Luca; Chiroli, Elena; Nezi, Luigi; Müller, Heiko; Piatti, Simonetta; Musacchio, Andrea; Ciliberto, Andrea
    Role of the Mad2 dimerization interface in the spindle assembly checkpoint independent of kinetochores
    In: Current Biology, Vol. 22, 2012, Nr. 20, pp. 1900 – 1908
    DOI

    • 2011

  • Perrakis, Anastassis; Musacchio, Andrea; Cusack, Stephen; Petosa, Carlo
    Investigating a macromolecular complex : the toolkit of methods
    In: Journal of Structural Biology, Vol. 175, 2011, Nr. 2, pp. 106 – 112
    DOI
  • Maure, Jean-François; Komoto, Shinya; Oku, Yusuke; Mino, Akihisa; Pasqualato, Sebastiano; Natsume, Kayo; Clayton, Lesley; Musacchio, Andrea; Tanaka, Tomoyuki U.
    The Ndc80 loop region facilitates formation of kinetochore attachment to the dynamic microtubule plus end
    In: Current Biology, Vol. 21, 2011, Nr. 3, pp. 207 – 213
    DOI
  • Musacchio, Andrea
    Travel notes from the equatorial circle
    In: Cell, Vol. 146, 2011, Nr. 4, pp. 499 – 501
    DOI
  • Maspero, Elena; Mari, Sara; Valentini, Eleonora; Musacchio, Andrea; Fish, Alexander; Pasqualato, Sebastiano; Polo, Simona
    Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation
    In: EMBO Reports, Vol. 12, 2011, Nr. 4, pp. 342 – 349
    DOI
  • Balzano, Deborah; Santaguida, Stefano; Musacchio, Andrea; Villa, Fabrizio
    A general framework for inhibitor resistance in protein kinases : Erratum
    In: Chemistry and Biology, Vol. 18, 2011, Nr. 10, pp. 1341
    DOI
  • Mattiuzzo, Marta; Vargiu, Giulia; Totta, Pierangela; Fiore, Mario; Ciferri, Claudio; Musacchio, Andrea; Degrassi, Francesca
    Abnormal kinetochore-generated pulling forces from expressing a n-terminally modified Hec1
    In: PLoS ONE, Vol. 6, 2011, Nr. 1, pp. e16307
    DOI (Open Access)
  • Balzano, Deborah; Santaguida, Stefano; Musacchio, Andrea; Villa, Fabrizio
    A general framework for inhibitor resistance in protein kinases
    In: Chemistry and Biology, Vol. 18, 2011, Nr. 8, pp. 966 – 975
    DOI
  • Varetti, Gianluca; Guida, Claudia; Santaguida, Stefano; Chiroli, Elena; Musacchio, Andrea
    Homeostatic control of mitotic arrest
    In: Molecular Cell, Vol. 44, 2011, Nr. 5, pp. 710 – 720
    DOI
  • Santaguida, Stefano; Vernieri, Claudio; Villa, Fabrizio; Ciliberto, Andrea; Musacchio, Andrea
    Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction
    In: The EMBO Journal, Vol. 30, 2011, Nr. 8, pp. 1508 – 1519
    DOI
  • Screpanti, Emanuela; De Antoni, Anna; Alushin, Gregory M.; Petrovic, Arsen; Melis, Tiziana; Nogales, Eva; Musacchio, Andrea
    Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore
    In: Current Biology, Vol. 21, 2011, Nr. 5, pp. 391 – 398
    DOI
  • Musacchio, Andrea
    Spindle assembly checkpoint : the third decade
    In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 366, 2011, Nr. 1584, pp. 3595 – 3604
    DOI
  • Alexander, Jes; Lim, Daniel; Joughin, Brian A.; Hegemann, Björn; Hutchins, James R. A.; Ehrenberger, Tobias; Ivins, Frank; Sessa, Fabio; Hudecz, Otto; Nigg, Erich A.; Fry, Andrew M.; Musacchio, Andrea; Stukenberg, P. Todd; Mechtler, Karl; Peters, Jan-Michael; Smerdon, Stephen J.; Yaffe, Michael B.
    Spatial exclusivity combined with positive and negative selection of phosphorylation motifs Is the basis for context-dependent mitotic signaling
    In: Science Signaling, Vol. 4, 2011, Nr. 179, 1-15, art. no. ra42
    DOI

    • 2010

  • Santaguida, Stefano; Tighe, Anthony; D'Alise, Anna M.; Taylor, Stephen S.; Musacchio, Andrea
    Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine
    In: The Journal of Cell Biology (JCB), Vol. 190, 2010, Nr. 1, pp. 73 – 87
    DOI
  • Civril, Filiz; Wehenkel, Annemarie; Giorgi, Federico M.; Santaguida, Stefano; Di Fonzo, Andrea; Grigorean, Gabriela; Ciccarelli, Francesca D.; Musacchio, Andrea
    Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery
    In: Structure, Vol. 18, 2010, Nr. 5, pp. 616 – 626
    DOI
  • Petrovic, Arsen; Pasqualato, Sebastiano; Dube, Prakash; Krenn, Veronica; Santaguida, Stefano; Cittaro, Davide; Monzani, Silvia; Massimiliano, Lucia; Keller, Jenny; Tarricone, Aldo; Maiolica, Alessio; Stark, Holger; Musacchio, Andrea
    The MIS12 complex is a protein interaction hub for outer kinetochore assembly
    In: The Journal of Cell Biology (JCB), Vol. 190, 2010, Nr. 5, pp. 835 – 852
    DOI
  • Musacchio, Andrea
    Cell cycle : deconstructing tension
    In: Current Biology, Vol. 20, 2010, Nr. 15, pp. R634 – R637
    DOI
  • Hewitt, Laura; Tighe, Anthony; Santaguida, Stefano; White, Anne M.; Jones, Clifford D.; Musacchio, Andrea; Green, Stephen; Taylor, Stephen S.
    Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex
    In: The Journal of Cell Biology (JCB), Vol. 190, 2010, Nr. 1, pp. 25 – 34
    DOI

    • 2009

  • Santaguida, Stefano; Musacchio, Andrea
    The life and miracles of kinetochores
    In: The EMBO Journal, Vol. 28, 2009, Nr. 17, pp. 2511 – 2531
    DOI
  • Villa, Fabrizio; Capasso, Paola; Tortorici, Marcello; Forneris, Federico; De Marco, Ario; Mattevi, Andrea; Musacchio, Andrea
    Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 106, 2009, Nr. 48, pp. 20204 – 20209
    DOI
  • Nezi, Luigi; Musacchio, Andrea
    Sister chromatid tension and the spindle assembly checkpoint
    In: Current Opinion in Cell Biology, Vol. 21, 2009, Nr. 6, pp. 785 – 795
    DOI
  • Amabile, Giovanni; D'Alise, Anna M.; Iovino, Mariangela; Jones, Philip; Santaguida, Stefano; Musacchio, Andrea; Taylor, Stephen; Cortese, Riccardo
    The Aurora B kinase activity is required for the maintenance of the differentiated state of murine myoblasts
    In: Cell death and differentiation, Vol. 16, 2009, Nr. 2, pp. 321 – 330
    DOI

    • 2008

  • Varetti, Gianluca; Musacchio, Andrea
    The spindle assembly checkpoint : correction
    In: Current biology, Vol. 18, 2008, Nr. 18, pp. 1444
    DOI
  • Civril, Filiz; Musacchio, Andrea
    Spindly attachments
    In: Genes and development, Vol. 22, 2008, Nr. 17, pp. 2302 – 2307
    DOI
  • Varetti, Gianluca; Musacchio, Andrea
    The spindle assembly checkpoint
    In: Current biology, Vol. 18, 2008, Nr. 14, pp. R591 – R595
    DOI
  • Ciferri, Claudio; Pasqualato, Sebastiano; Screpanti, Emanuela; Varetti, Gianluca; Santaguida, Stefano; Dos Reis, Gabriel; Maiolica, Alessio; Polka, Jessica; De Luca, Jennifer G.; De Wulf, Peter; Salek, Mogjiborahman; Rappsilber, Juri; Moores, Carolyn A.; Salmon, Edward D.; Musacchio, Andrea
    Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex
    In: Cell, Vol. 133, 2008, Nr. 3, pp. 427 – 439
    DOI
  • Andersen, Carsten B.; Wan, Yongqin; Chang, Jae W.; Riggs, Blake; Lee, Christian; Liu, Yi; Sessa, Fabio; Villa, Fabrizio; Kwiatkowski, Nicholas; Suzuki, Melissa; Nallan, Laxman; Heald, Rebecca; Musacchio, Andrea; Gray, Nathanael S.
    Discovery of selective aminothiazole aurora kinase inhibitors
    In: ACS Chemical Biology, Vol. 3, 2008, Nr. 3, pp. 180 – 192
    DOI

    • 2007

  • Plyte, Simon; Musacchio, Andrea
    PLK1 inhibitors : setting the mitotic death trap
    In: Current biology, Vol. 17, 2007, Nr. 8, pp. R280 – R283
    DOI
  • Musacchio, Andrea; Salmon, Edward D.
    The spindle-assembly checkpoint in space and time
    In: Nature reviews : molecular cell biology, Vol. 8, 2007, Nr. 5, pp. 379 – 393
    DOI
  • Mapelli, Marina; Massimiliano, Lucia; Santaguida, Stefano; Musacchio, Andrea
    The Mad2 conformational dimer : structure and implications for the spindle assembly checkpoint
    In: Cell, Vol. 131, 2007, Nr. 4, pp. 730 – 743
    DOI
  • Derewenda, Urszula; Tarricone, Cataldo; Choi, Won C.; Cooper, David R.; Lukasik, Steve; Perrina, Franco; Tripathy, Ashutosh; Kim, Myung H.; Cafiso, David S.; Musacchio, Andrea; Derewenda, Zygmunt S.
    The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly
    In: Structure, Vol. 15, 2007, Nr. 11, pp. 1467 – 1481
    DOI
  • Mapelli, Marina; Musacchio, Andrea
    MAD contortions : conformational dimerization boosts spindle checkpoint signaling
    In: Current opinion in structural biology, Vol. 17, 2007, Nr. 6, pp. 716 – 725
    DOI
  • Ciferri, Claudio; Musacchio, Andrea; Petrovic, Arsen
    The Ndc80 complex : hub of kinetochore activity
    In: FEBS Letters, Vol. 581, 2007, Nr. 15, pp. 2862 – 2869
    DOI

    • 2006

  • Vink, Martin; Simonetta, Marco; Transidico, Pietro; Ferrari, Karin; Mapelli, Marina; De Antoni, Anna; Massimiliano, Lucia; Ciliberto, Andrea; Faretta, Mario; Salmon, Edward D.; Musacchio, Andrea
    In vitro FRAP identifies the minimal requirements for Mad2 kinetochore dynamics
    In: Current biology, Vol. 16, 2006, Nr. 8, pp. 755 – 766
    DOI
  • Penengo, Lorenza; Mapelli, Marina; Murachelli, Andrea G.; Confalonieri, Stefano; Magri, Laura; Musacchio, Andrea; Di Fiore, Pier P.; Polo, Simona; Schneider, Thomas R.
    Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin
    In: Cell, Vol. 124, 2006, Nr. 6, pp. 1183 – 1195
    DOI
  • Nezi, Luigi; Rancati, Giulia; De Antoni, Anna; Pasqualato, Sebastiano; Piatti, Simonetta; Musacchio, Andrea
    Accumulation of Mad2-Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae
    In: The Journal of Cell Biology (JCB), Vol. 174, 2006, Nr. 1, pp. 39 – 51
    DOI
  • DeLuca, Jennifer G.; Gall, Walter E.; Ciferri, Claudio; Cimini, Daniela; Musacchio, Andrea; Salmon, Edward D.
    Kinetochore microtubule dynamics and attachment stability are regulated by Hec1
    In: Cell, Vol. 127, 2006, Nr. 5, pp. 969 – 982
    DOI
  • Mapelli, Marina; Filipp, Fabian V.; Rancati, Giulia; Massimiliano, Lucia; Nezi, Luigi; Stier, Gunter; Hagan, Robert S.; Confalonieri, Stefano; Piatti, Simonetta; Sattler, Michael; Musacchio, Andrea
    Determinants of conformational dimerization of Mad2 and its inhibition by p31comet
    In: The EMBO Journal, Vol. 25, 2006, Nr. 6, pp. 1273 – 1284
    DOI

    • 2005

  • Sessa, Fabio; Mapelli, Marina; Ciferri, Claudio; Tarricone, Cataldo; Areces, Liliana B.; Schneider, Thomas R.; Stukenberg, P. Todd; Musacchio, Andrea
    Mechanism of Aurora B activation by INCENP and inhibition by Hesperadin
    In: Molecular cell, Vol. 18, 2005, Nr. 3, pp. 379 – 391
    DOI
  • De Antoni, Anna; Sala, Valeria; Musacchio, Andrea
    Explaining the oligomerization properties of the spindle assembly checkpoint protein Mad2
    In: Philosophical transactions of the Royal Society : series B, biological sciences, Vol. 360, 2005, Nr. 1455, pp. 637 – 648
    DOI
  • Ciferri, Claudio; De Luca, Jennifer; Monzani, Silvia; Ferrari, Karin J.; Ristic, Dejan; Wyman, Claire; Stark, Holger; Kilmartin, John; Salmon, Edward D.; Musacchio, Andrea
    Architecture of the human Ndc80-Hec1 complex, a critical constituent of the outer kinetochore
    In: The Journal of Biological Chemistry (JBC), Vol. 280, 2005, Nr. 32, pp. 29088 – 29095
    DOI
  • De Antoni, Anna; Pearson, Chad G.; Cimini, Daniela; Canman, Julie C.; Sala, Valeria; Nezi, Luigi; Mapelli, Marina; Sironi, Lucia; Faretta, Mario; Salmon, Edward D.; Musacchio, Andrea
    The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint
    In: Current biology, Vol. 15, 2005, Nr. 3, pp. 214 – 225
    DOI

    • 2003

  • Mapelli, Marina; Musacchio, Andrea
    The structural perspective on CDK5
    In: Neurosignals, Vol. 12, 2003, Nr. 4-5, pp. 164 – 172
    DOI

    • 2002

  • Sironi, Lucia; Mapelli, Marina; Knapp, Stefan; De Antoni, Anna; Jeang, Kuan‐Teh; Musacchio, Andrea
    Crystal structure of the tetrameric Mad1-Mad2 core complex : implications of 'safety belt' binding mechanism for the spindle checkpoint
    In: The EMBO Journal, Vol. 21, 2002, Nr. 10, pp. 2496 – 2506
    DOI
  • Musacchio, Andrea; Hardwick, Kevin G.
    The spindle checkpoint : structural insights into dynamic signalling
    In: Nature reviews : molecular cell biology, Vol. 3, 2002, Nr. 10, pp. 731 – 741
    DOI

    • 2001

  • Fraschini, Roberta; Beretta, Alessia; Sironi, Lucia; Musacchio, Andrea; Lucchini, Giovanna; Piatti, Simonetta
    Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores
    In: The EMBO Journal, Vol. 20, 2001, Nr. 23, pp. 6648 – 6659
    DOI
  • Sironi, Lucia; Melixetian, Marina; Faretta, Mario; Prosperini, Elena; Helin, Kristian; Musacchio, Andrea
    Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for spindle checkpoint
    In: The EMBO Journal, Vol. 20, 2001, Nr. 22, pp. 6371 – 6382
    DOI
  • Tarricone, Cataldo; Dhavan, Rani; Peng, Junmin; Areces, Liliana B.; Tsai, Li-Huei; Musacchio, Andrea
    Structure and regulation of the CDK5-p25nck5a complex
    In: Molecular cell, Vol. 8, 2001, Nr. 3, pp. 657 – 669
    DOI

    • 2000

  • Orrico, Alfredo; Galli, Lucia; Falciani, Michela; Bracci, Martina; Cavaliere, Maria L.; Rinaldi, Maria M.; Musacchio, Andrea; Sorrentino, Vincenzo
    A mutation in the pleckstrin homology (PH) domain of the FGD1 gene in an Italian family with faciogenital dysplasia (Aarskog-Scott syndrome)
    In: FEBS Letters, Vol. 478, 2000, Nr. 3, pp. 216 – 220
    DOI
  • Kang, Hyun; Freund, Christian; Duke‐Cohan, Jonathan S.; Musacchio, Andrea; Wagner, Gerhard; Rudd, Christopher E.
    SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55
    In: The EMBO Journal, Vol. 19, 2000, Nr. 12, pp. 2889 – 2899
    DOI

    • 1999

  • Mongioví, Adriana M.; Romano, Pascale R.; Panni, Simona; Mendoza, Manuel; Wong, William T.; Musacchio, Andrea; Cesareni, Gianni; Di Fiore, Pier P.
    A novel peptide-SH3 interaction
    In: The EMBO Journal, Vol. 18, 1999, Nr. 19, pp. 5300 – 5309
    DOI
  • Musacchio, Andrea; Smith, Corinne J.; Roseman, Alan M.; Harrison, Stephen C.; Kirchhausen, Tomas; Pearse, Barbara M. F.
    Functional organization of clathrin in coats : combining electron cryomicroscopy and x-ray crystallography
    In: Molecular cell, Vol. 3, 1999, Nr. 6, pp. 761 – 770
    DOI

    • 1998

  • Ter Haar, Ernst; Musacchio, Andrea; Harrison, Stephen C.; Kirchhausen, Tomas
    Atomic structure of clathrin : a β propeller terminal domain joins an α zigzag linker
    In: Cell, Vol. 95, 1998, Nr. 4, pp. 563 – 573
    DOI

    • 1996

  • Musacchio, Andrea; Cantley, Lewis C.; Harrison, Stephen C.
    Crystal structure of the breakpoint cluster region homology domain from phosphoinositide 3-kinase p85 alpha subunit
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 93, 1996, Nr. 25, pp. 14373 – 14378
    DOI

    • 1994

  • Saraste, Matti; Musacchio, Andrea
    Backwards and forwards binding
    In: Nature structural biology, Vol. 1, 1994, Nr. 12, pp. 835 – 837
    DOI
  • Musacchio, Andrea; Wilmanns, Matthias; Saraste, Matti
    Structure and function of the SH3 domain
    In: Progress in biophysics and molecular biology, Vol. 61, 1994, Nr. 3, pp. 283 – 297
    DOI

    • 1993

  • Musacchio, Andrea; Gibson, Toby; Rice, Peter; Thompson, Julie; Saraste, Matti
    The PH domain : a common piece in the structural pathcwork of signalling proteins
    In: Trends in biochemical sciences, Vol. 18, 1993, Nr. 9, pp. 343 – 348
    DOI
  • Noble, Martin E. M.; Musacchio, Andrea; Saraste, Matti; Courtneidge, Sara A.; Wierenga, Rik K.
    Crystal structure of the SH3 domain in human Fyn : comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin
    In: The EMBO Journal, Vol. 12, 1993, Nr. 7, pp. 2617 – 2624
    Online Full Text
  • Van der Oost, John; Musacchio, Andrea; Pauptit, Richard A.; Ceska, Thomas A.; Wierenga, Rik K.; Saraste, Matti
    Crystallization and preliminary x-ray analysis of the periplasmic fragment of CyoA-a subunit of the Escherichia coli cytochrome o complex
    In: Journal of Molecular Biology (JMB), Vol. 229, 1993, Nr. 3, pp. 794 – 796
    DOI

    • 1992

  • Musacchio, Andrea; Noble, Martin; Pauptit, Richard; Wierenga, Rik; Saraste, Matti
    Crystal structure of a Src-homology 3 (SH3) domain
    In: Nature, Vol. 359, 1992, Nr. 6398, pp. 851 – 855
    DOI
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