ZMB Site - Medical Faculty / University Hospital Essen

ZMB Research
Sites

Medical Faculty / University Hospital Essen

Selected Publications

Prof. Dr.Sebastian Bauer

Group: Translational Sarcoma Research

ZMB Research Program: Oncology

Prof. Dr. Dr.Jürgen Becker

Group: Translational Skin Cancer Research

ZMB Research Program: Oncology

Prof. Dr.Ivo Bendix

Group: Experimental Perinatal Neuroscience

Prof. Dr. Dr.Sven Brandau

Group:Otorhinolaryngology

ZMB Research Program: Oncology

Prof. Dr.Jan Buer

Director of: Institute of Medical Microbiology

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Elke Cario

Group: Experimental Gastroenterology

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Ulf Dittmer

Director of: Institute of Virology

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Nicole Dünker

Group: Neuroanatomy

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Joachim Fandrey

Director of: Institute of Physiology

ZMB Research Program: Molecular and Chemical Cell Biology

Jun.-Prof. Dr.Katja Ferenz

Group: Institute of Physiology

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Katharina Fleischhauer

Director of: Institute for Experimental Cellular Therapy

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Stefanie Flohé

Group: Immunology Sepsis/Trauma

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Dagmar Führer-Sakel

Director of: Clinic for Endocrinology, Diabetology and Metabolism

ZMB Research Program: Oncology

Prof. Dr.Bernd Giebel

Group: Giebel Lab

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Barbara M. Grüner

Group: Molecular Tumorpathology

ZMB Research Program: Oncology

Prof. Dr.Barbara Grünwald

Group: Tumor Heterogeneity and Translational Systems Biology

ZMB Research Program: Oncology

Prof. Dr.Erich Gulbins

Director of: Department of Molecular Biology

ZMB Research Program: Oncology

Prof. Dr.Matthias Gunzer

Director of: Institute of Experimental Immunology & Imaging

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Wiebke Hansen

Group: Molecular Infection Immunology

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Ulrike Hendgen-Cotta

Manager of: Cardio Science Labs

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Dirk M. Hermann

Group: Vascular Neurology, Dementia and Age Research

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Ken Herrmann

Group: Clinic for Nuclear Medicine

ZMB Research Program: Oncology

Prof. Dr.Heike Heuer

Group: Molecular Thyroidology

ZMB Research Program: Molecular and Chemical Cell Biology

PD Dr.Josephine Herz

Group: Experimental Perinatal Neuroscience

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Anke Hinney

Group: LVR Clinic for Psychiatry Essen

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Peter Horn

Director of: Institute for Transfusion Medicine

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.George Iliakis

Group: Radiation Biology

ZMB Research Program: Oncology

Prof. Dr.Jadwiga Jablonska-Koch

Group:Otorhinolaryngology (ENT)

ZMB Research Program: Oncology

Prof. Dr.Verena Jendrossek

Group: Molecular Cell Biology

ZMB Research Program: Oncology

Prof. Dr.Carsten Kirschning

Group: Regulation of Pathogen-specific Immunity

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Diana Klein

Group: Vascular Remodeling & Normal Tissue Protection

ZMB Research Program: Oncology

Prof. Dr.Christoph Kleinschnitz

Director of: Clinic for Neurology

ZMB Research Program: Molecular and Chemical Cell Biology

PD Dr.Adalbert Krawczyk

Group: Clinic for Infectious Diseases

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Ralf Küppers

Director of: Institute of Cell Biology (Tumor Research)

ZMB Research Program: Oncology

Prof. Dr.Karl Sebastian Lang

Director of: Institute of Immunology

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr.Dietmar Lohmann

Group: Ophthalmic Oncology and Genetics

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Katharina Lückerath

Group: Preclinical Theranostics in Nuclear Medicine

ZMB Research Program: Oncology

PD Dr.Johann Matschke

Group: Metabolism and Radiation Response

ZMB Research Program: Oncology

Prof. Dr.Cläre von Neubeck

Group: Translational Particle Therapy

ZMB Research Program: Oncology

Prof. Dr.Annette Paschen

Group: Molecular Tumor Immunology

ZMB Research Program: Oncology

Dr.Samuel Peña-Llopis

Junior Group: Translational Genomics in Solid Tumors

ZMB Research Program: Oncology

Prof. Dr.Tienush Rassaf

Director of: Clinic for Cardiology and Vascular Medicine

ZMB Research Program: Oncology

Prof. Dr.Christian Reinhardt

Director of: Clinic for Hematology and Stem Cell Transplantation

ZMB Research Program: Oncology

Prof. Dr.Alexander Roesch

Group: Tumor Heterogeneity & Plasticity

ZMB Research Program: Oncology

Prof. Dr.Dirk Schadendorf

Director of: Clinic for Dermatology

ZMB Research Program: Oncology

Prof. Dr.Björn Scheffler

Group: Translational Neurooncology

ZMB Research Program: Oncology

Prof. Dr.Alexander Schramm

Group: Molecular Oncology

ZMB Research Program: Oncology

Prof. Dr.Martin Schuler

Director of: Department of Medical Oncology

ZMB Research Program: Oncology

Prof. Dr.Winfried Siffert

Director of: Institute of Pharmacogenetics

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr. Dr.Jens Siveke

Group: Bridge Institute for Experimental Tumor Therapy

ZMB Research Program: Oncology

PD Dr.Kathrin Sutter

TRR60 Junior Research Group: Interferone-alpha Subtypes

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

Prof. Dr. Dr.Alpaslan Tasdogan

Group: Tumor Metabolism

ZMB Research Program: Oncology

PD Dr.Basant Kumar Thakur

Group: Cancer Exosome Research Lab

ZMB Research Program: Oncology

Dr.Silvia Vega-Rubín-de-Celis

Junior Research Group: Autophagy in Cancer

ZMB Research Program: Oncology

Prof. Dr.Gunther Wennemuth

Director of: Institute of Anatomy

ZMB Research Program: Molecular and Chemical Cell Biology

Prof. Dr.Astrid Westendorf

Group: Infection Immunology

ZMB Research Program: Immunology, Infectious Diseases and Transplantation

2024

Roos, Andreas; Schmitt, Linda-Isabell; Hansmann, Christina; Hezel, Stefanie; Salmanian, Schahin; Hentschel, Andreas; Meyer, Nancy; Marina, Adela Della; Kölbel, Heike; Kleinschnitz, Christoph; Schara-Schmidt, Ulrike; Leo, Markus; Hagenacker, Tim

Alteration of LARGE1 abundance in patients and a mouse model of 5q-associated spinal muscular atrophy

In: Acta Neuropathologica Vol. 147 (2024) Nr. 1, 53

Online Full Text: dx.doi.org/ (Open Access)
Lüsebrink, Enzo; Binzenhöfer, Leonhard; Hering, Daniel; Villegas Sierra, Laura; Schrage, Benedikt; Scherer, Clemens; Speidl, Walter S.; Uribarri, Aitor; Sabate, Manel; Noc, Marko; Sandoval, Elena; Erglis, Andrejs; Pappalardo, Federico; De Roeck, Frederic; Tavazzi, Guido; Riera, Jordi; Roncon-Albuquerque, Roberto; Meder, Benjamin; Lüdike, Peter; Rassaf, Tienush; Hausleiter, Jörg; Hagl, Christian; Zimmer, Sebastian; Westermann, Dirk; Combes, Alain; Zeymer, Uwe; Massberg, Steffen; Schäfer, Andreas; Orban, Martin; Thiele, Holger

Scrutinizing the Role of Venoarterial Extracorporeal Membrane Oxygenation : Has Clinical Practice Outpaced the Evidence?

In: Circulation Vol. 149 (2024) Nr. 13, pp. 1033 - 1052

Online Full Text: dx.doi.org/
Massoni-Badosa, Ramon; Aguilar-Fernández, Sergio; Nieto, Juan C.; Soler-Vila, Paula; Elosua-Bayes, Marc; Marchese, Domenica; Kulis, Marta; Vilas-Zornoza, Amaia; Bühler, Marco Matteo; Rashmi, Sonal; Alsinet, Clara; Caratù, Ginevra; Moutinho, Catia; Ruiz, Sara; Lorden, Patricia; Lunazzi, Giulia; Colomer, Dolors; Frigola, Gerard; Blevins, Will; Romero-Rivero, Lucia; Jiménez-Martínez, Víctor; Vidal, Anna; Mateos-Jaimez, Judith; Maiques-Diaz, Alba; Ovejero, Sara; Moreaux, Jérôme; Palomino, Sara; Gomez-Cabrero, David; Agirre, Xabier; Weniger, Marc A.; King, Hamish W.; Garner, Lucy C.; Marini, Federico; Cervera-Paz, Francisco Javier; Baptista, Peter M.; Vilaseca, Isabel; Rosales, Cecilia; Ruiz-Gaspà, Silvia; Talks, Benjamin; Sidhpura, Keval; Pascual-Reguant, Anna; Hauser, Anja E.; Haniffa, Muzlifah; Prosper, Felipe; Küppers, Ralf; Gut, Ivo Glynne; Campo, Elias; Martin-Subero, José Ignacio; Heyn, Holger

An atlas of cells in the human tonsil

In: Immunity Vol. 57 (2024) Nr. 2, pp. 379 - 399.e18

Online Full Text: dx.doi.org/ (Open Access)
Tretter, Celina; de Andrade Krätzig, Niklas; Pecoraro, Matteo; Lange, Sebastian; Seifert, Philipp; von Frankenberg, Clara; Untch, Johannes; Zuleger, Gabriela; Wilhelm, Mathias; Zolg, Daniel P.; Dreyer, Florian S.; Bräunlein, Eva; Engleitner, Thomas; Uhrig, Sebastian; Boxberg, Melanie; Steiger, Katja; Slotta-Huspenina, Julia; Ochsenreither, Sebastian; von Bubnoff, Nikolas; Bauer, Sebastian; Boerries, Melanie; Jost, Philipp J.; Schenck, Kristina; Dresing, Iska; Bassermann, Florian; Friess, Helmut; Reim, Daniel; Grützmann, Konrad; Pfütze, Katrin; Klink, Barbara; Schröck, Evelin; Haller, Bernhard; Kuster, Bernhard; Mann, Matthias; Weichert, Wilko; Fröhling, Stefan; Rad, Roland; Hiltensperger, Michael; Krackhardt, Angela M.

Correction to: Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification

In: Nature Communications Vol. 15 (2024) Nr. 1, 2364

Online Full Text: dx.doi.org/ (Open Access)
George, Julie; Maas, Lukas; Abedpour, Nima; Cartolano, Maria; Kaiser, Laura; Fischer, Rieke N.; Scheel, Andreas H.; Weber, Jan-Philipp; Hellmich, Martin; Bosco, Graziella; Volz, Caroline; Mueller, Christian; Dahmen, Ilona; John, Felix; Alves, Cleidson Padua; Werr, Lisa; Panse, Jens Peter; Kirschner, Martin; Engel-Riedel, Walburga; Jürgens, Jessica; Stoelben, Erich; Brockmann, Michael; Grau, Stefan; Sebastian, Martin; Stratmann, Jan A.; Kern, Jens; Hummel, Horst-Dieter; Hegedüs, Balazs; Schuler, Martin; Plönes, Till; Aigner, Clemens; Elter, Thomas; Toepelt, Karin; Ko, Yon-Dschun; Kurz, Sylke; Grohé, Christian; Serke, Monika; Höpker, Katja; Hagmeyer, Lars; Doerr, Fabian; Hekmath, Khosro; Strapatsas, Judith; Kambartel, Karl-Otto; Chakupurakal, Geothy; Busch, Annette; Bauernfeind, Franz-Georg; Griesinger, Frank; Luers, Anne; Dirks, Wiebke; Wiewrodt, Rainer; Luecke, Andrea; Rodermann, Ernst; Diel, Andreas; Hagen, Volker; Severin, Kai; Ullrich, Roland T.; Reinhardt, Hans Christian; Quaas, Alexander; Bogus, Magdalena; Courts, Cornelius; Nürnberg, Peter; Becker, Kerstin; Achter, Viktor; Büttner, Reinhard; Wolf, Jürgen; Peifer, Martin; Thomas, Roman K.

Evolutionary trajectories of small cell lung cancer under therapy

In: Nature (2024) in press

Online Full Text: dx.doi.org/ (Open Access)
Knittel, Gero; Reinhardt, Hans Christian

XPO1-Mediated mRNA Export of Genome Maintenance Regulators Drives Chemotherapy Resistance in Aggressive Lymphoma

In: Cancer Research Vol. 84 (2024) Nr. 1, pp. 3 - 5

Online Full Text: dx.doi.org/
Heger, Jan-Michel; Mattlener, Julia; Schneider, Jessica; Gödel, Philipp; Sieg, Noëlle; Ullrich, Fabian; Lewis, Richard; Bucaciuc-Mracica, Teodora; Schwarz, Roland F.; Rueß, Daniel; Ruge, Maximilian I.; Montesinos-Rongen, Manuel; Deckert, Martina; Blau, Tobias; Kutsch, Nadine; Balke-Want, Hyatt; Weiss, Jonathan; Becker, Kerstin; Reinhardt, H. Christian; Hallek, Michael; Borchmann, Peter; von Tresckow, Bastian; Borchmann, Sven

Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNA

In: Blood Vol. 143 (2024) Nr. 6, pp. 522 - 534

Online Full Text: dx.doi.org/
Heinrich, Michael C.; Jones, Robin L.; George, Suzanne; Gelderblom, Hans; Schöffski, Patrick; von Mehren, Margaret; Zalcberg, John R.; Kang, Yoon-Koo; Razak, Albiruni Abdul; Trent, Jonathan; Attia, Steven; Le Cesne, Axel; Siontis, Brittany L.; Goldstein, David; Boye, Kjetil; Sanchez, Cesar; Steeghs, Neeltje; Rutkowski, Piotr; Druta, Mihaela; Serrano, César; Somaiah, Neeta; Chi, Ping; Reichmann, William; Sprott, Kam; Achour, Haroun; Sherman, Matthew L.; Ruiz-Soto, Rodrigo; Blay, Jean-Yves; Bauer, Sebastian

Ripretinib versus sunitinib in gastrointestinal stromal tumor : ctDNA biomarker analysis of the phase 3 INTRIGUE trial

In: Nature Medicine (2024) in press

Online Full Text: dx.doi.org/ (Open Access)
Pozniak, Joanna; Pedri, Dennis; Landeloos, Ewout; Van Herck, Yannick; Antoranz, Asier; Vanwynsberghe, Lukas; Nowosad, Ada; Roda, Niccolò; Makhzami, Samira; Bervoets, Greet; Maciel, Lucas Ferreira; Pulido-Vicuña, Carlos Ariel; Pollaris, Lotte; Seurinck, Ruth; Zhao, Fang; Flem-Karlsen, Karine; Damsky, William; Chen, Limin; Karagianni, Despoina; Cinque, Sonia; Kint, Sam; Vandereyken, Katy; Rombaut, Benjamin; Voet, Thierry; Vernaillen, Frank; Annaert, Wim; Lambrechts, Diether; Boecxstaens, Veerle; Saeys, Yvan; van den Oord, Joost; Bosisio, Francesca; Karras, Panagiotis; Shain, A. Hunter; Bosenberg, Marcus; Leucci, Eleonora; Paschen, Annette; Rambow, Florian; Bechter, Oliver; Marine, Jean-Christophe

A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma

In: Cell Vol. 187 (2024) Nr. 1, pp. 166 - 183.e25

Online Full Text: dx.doi.org/ (Open Access)
Teuber, A.; Schulz, T.; Fletcher, B.S.; Gontla, R.; Mühlenberg, Thomas; Zischinsky, M.-L.; Niggenaber, J.; Weisner, J.; Kleinbölting, S.B.; Lategahn, J.; Sievers, S.; Müller, M.P.; Bauer, Sebastian; Rauh, D.

Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA

In: Nature Communications Vol. 15 (2024) Nr. 1, 63

Online Full Text: dx.doi.org/ (Open Access)

2023

Cibir, Zülal; Hassel, Jacqueline; Sonneck, Justin; Kowitz, Lennart; Beer, Alexander; Kraus, Andreas; Hallekamp, Gabriel; Rosenkranz, Martin; Raffelberg, Pascal; Olfen, Sven; Smilowski, Kamil; Burkard, Roman; Helfrich, Iris; Tuz, Ali Ata; Singh, Vikramjeet; Ghosh, Susmita; Sickmann, Albert; Klebl, Anne-Kathrin; Eickhoff, Jan Eike; Klebl, Bert; Seidl, Karsten; Chen, Jianxu; Grabmaier, Anton; Viga, Reinhard; Gunzer, Matthias

ComplexEye : a multi-lens array microscope for high-throughput embedded immune cell migration analysis

In: Nature Communications Vol. 14 (2023) Nr. 1, 8103

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Yuan, Yuan; Küppers, Ralf; Schadendorf, Dirk; Park, Keunchil; Campbell, Peter J.; Liang, Han

Comprehensive molecular characterization of mitochondrial genomes in human cancers

In: Nature Genetics Vol. 52 (2023) pp. 342 - 352

Online Full Text: dx.doi.org/ (Open Access)
Akdemir, Kadir C.; Küppers, Ralf; Schadendorf, Dirk; Futreal, P. Andrew

Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

In: Nature Genetics Vol. 52 (2023) Nr. 3, pp. 294 - 305

Online Full Text: dx.doi.org/ (Open Access)
Joensuu, Heikki; Wardelmann, Eva; Eriksson, Mikael; Reichardt, Annette; Hall, Kirsten Sundby; Schütte, Jochen; Cameron, Silke; Hohenberger, Peter; Sihto, Harri; Jost, Philipp J.; Lindner, Lars H.; Bauer, Sebastian; Nilsson, Bengt; Kallio, Raija; Pesonen, Tommi; Reichardt, Peter

KIT and PDGFRA Mutations and Survival of Gastrointestinal Stromal Tumor Patients Treated with Adjuvant Imatinib in a Randomized Trial

In: Clinical Cancer Research Vol. 29 (2023) Nr. 17, pp. 3313 - 3319

Online Full Text: dx.doi.org/ (Open Access)
Zapatka, Marc; Schadendorf, Dirk; Lichter, Peter

Author Correction: The landscape of viral associations in human cancers

In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1077

Online Full Text: dx.doi.org/ (Open Access)
Cameron, Donald P.; Grosser, Jan; Ladigan, Swetlana; Kuzin, Vladislav; Iliopoulou, Evanthia; Wiegard, Anika; Benredjem, Hajar; Jackson, Kathryn; Liffers, Sven T.; Lueong, Smiths; Cheung, Phyllis F.; Vangala, Deepak; Pohl, Michael; Viebahn, Richard; Teschendorf, Christian; Wolters, Heiner; Usta, Selami; Geng, Keyi; Kutter, Claudia; Arsenian-Henriksson, Marie; Siveke, Jens; Tannapfel, Andrea; Schmiegel, Wolff; Hahn, Stephan A.; Baranello, Laura

Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription

In: Science Advances Vol. 9 (2023) Nr. 41, eadg5109

Online Full Text: dx.doi.org/ (Open Access)
Akdemir, Kadir C.; Küppers, Ralf; Schadendorf, Dirk; Futreal, P. Andrew

Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1079

Online Full Text: dx.doi.org/ (Open Access)
Karreman, Matthia A.; Bauer, Alexander T.; Solecki, Gergely; Berghoff, Anna S.; Mayer, Chanté D; Frey, Katharina; Hebach, Nils; Feinauer, Manuel J.; Schieber, Nicole L.; Tehranian, Cedric; Mercier, Luc; Singhal, Mahak; Venkataramani, Varun; Schubert, Marc C.; Hinze, Daniel; Hölzel, Michael; Helfrich, Iris; Schadendorf, Dirk; Schneider, Stefan W.; Westphal, Dana; Augustin, Hellmut G.; Goetz, Jacky G.; Schwab, Yannick; Wick, Wolfgang; Winkler, Frank

Active Remodeling of Capillary Endothelium via Cancer Cell-Derived MMP9 Promotes Metastatic Brain Colonization

In: Cancer Research Vol. 83 (2023) Nr. 8, pp. 1299 - 1314

Online Full Text: dx.doi.org/
Bayraktar, Evren; Graf, Theresa; Ayuk, Francis A.; Beutel, Gernot; Penack, Olaf; Luft, Thomas; Brueder, Nicole; Castellani, Gastone; Reinhardt, H. Christian; Kröger, Nicolaus; Beelen, Dietrich W.; Turki, Amin T.

Data-driven grading of acute graft-versus-host disease

In: Nature Communications Vol. 14 (2023) Nr. 1, 7799

Online Full Text: dx.doi.org/ (Open Access)
Frank, Daria; Patnana, Pradeep Kumar; Vorwerk, Jan; Mao, Lianghao; Gopal, Lavanya Mokada; Jung, Noelle; Hennig, Thorben; Ruhnke, Leo; Frenz, Joris Maximillian; Kuppusamy, Maithreyan; Autry, Robert; Wei, Lanying; Sun, Kaiyan; Mohammed Ahmed, Helal Mohammed; Künstner, Axel; Busch, Hauke; Müller, Heiko; Hutter, Stephan; Hoermann, Gregor; Liu, Longlong; Xie, Xiaoqing; Al-Matary, Yahya; Nimmagadda, Subbaiah Chary; Cano, Fiorella Charles; Heuser, Michael; Thol, Felicitas; Göhring, Gudrun; Steinemann, Doris; Thomale, Jürgen; Leitner, Theo; Fischer, Anja; Rad, Roland; Röllig, Christoph; Altmann, Heidi; Kunadt, Desiree; Berdel, Wolfgang E.; Hüve, Jana; Neumann, Felix; Klingauf, Jürgen; Calderon, Virginie; Opalka, Bertram; Dührsen, Ulrich; Rosenbauer, Frank; Dugas, Martin; Varghese, Julian; Reinhardt, Hans Christian; von Bubnoff, Nikolas; Möröy, Tarik; Lenz, Georg; Batcha, Aarif M. N.; Giorgi, Marianna; Selvam, Murugan; Wang, Eunice; McWeeney, Shannon K.; Tyner, Jeffrey W.; Stölzel, Friedrich; Mann, Matthias; Jayavelu, Ashok Kumar; Khandanpour, Cyrus; Mokada Gopal, Lavanya; Ahmed, Helal; Charles Cano, Fiorella

Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

In: Blood Vol. 142 (2023) Nr. 25, pp. 2175 - 2191

Online Full Text: dx.doi.org/ (Open Access)
Yuan, Yuan; Küppers, Ralf; Schadendorf, Dirk; Park, Keunchil; Campbell, Peter J.; Liang, Han

Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers

In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1078

Online Full Text: dx.doi.org/ (Open Access)
Becker, Jürgen; Ugurel, Selma; Leiter, Ulrike; Meier, Friedegund; Gutzmer, Ralf; Haferkamp, Sebastian; Zimmer, Lisa; Livingstone, Elisabeth; Eigentler, Thomas K; Hauschild, Axel; Kiecker, Felix; Hassel, Jessica C; Mohr, Peter; Fluck, Michael; Thomas, Ioannis; Garzarolli, Marlene; Grimmelmann, Imke; Drexler, Konstantin; Spillner, Alexandra N; Eckhardt, Sebastian; Schadendorf, Dirk; van Akkoi, Alexander; van Houdt, Winan; Wilhelm, Tabea; Farmer, Kimberly; Ulrich, Claas; Gambichler, Thilo; Bluhm, Leonie; Schinagl, Heidemarie; Kellner, Ivonne; Herbst, Rudolf; Meiß, Frank; Rafei-Shamsabadi, David; Sell, Sabine; Kaatz, Martin; Wulfken, Lena; Hartmann, Martin; Kähler, Katharina; Ziemer, Mirjana; Simon, Jan; Terheyden, Patrick; Thaci, Diamant; Loquai, Carmen; Mitzel-Rink, Heidrun; Grabbe, Stephan; Stege, Henner; Gaiser, Maria; Utikal, Jochen; Berking, Carola; Heinzerling, Lucie; Schlaak, Max; Tomsitz, Dirk; Dyballa, Jörg; Magnolo, Nina; Weishaupt, Carsten; Berneburg, Mark; Garbe, Claus; Flatz, Lukas; Gesierich, Anja; Schilling, Bastian

Adjuvant immunotherapy with nivolumab versus observation in completely resected Merkel cell carcinoma (ADMEC-O) : disease-free survival results from a randomised, open-label, phase 2 trial

In: Lancet Vol. 402 (2023) Nr. 10404, pp. 798 - 808

Online Full Text: dx.doi.org/
Cortés-Ciriano, Isidro; Küppers, Ralf; Schadendorf, Dirk; Park, Peter J.

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

In: Nature Genetics Vol. 52 (2023) pp. 331 - 341

Online Full Text: dx.doi.org/ (Open Access)
Cortés-Ciriano, Isidro; Küppers, Ralf; Schadendorf, Dirk; Park, Peter J.

Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

In: Nature Genetics Vol. 55 (2023) Nr. 6, 1076

Online Full Text: dx.doi.org/ (Open Access)
Zehner, Matthias; Alt, Mira; Ashurov, Artem; Goldsmith, Jory A.; Spies, Rebecca; Weiler, Nina; Lerma, Justin; Gieselmann, Lutz; Stöhr, Dagmar; Gruell, Henning; Schultz, Eric P.; Kreer, Christoph; Schlachter, Linda; Janicki, Hanna; Laib Sampaio, Kerstin; Stegmann, Cora; Nemetchek, Michelle D.; Dähling, Sabrina; Ullrich, Leon; Dittmer, Ulf; Witzke, Oliver; Koch, Manuel; Ryckman, Brent J.; Lotfi, Ramin; McLellan, Jason S.; Krawczyk, Adalbert; Sinzger, Christian; Klein, Florian

Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer

In: Immunity Vol. 56 (2023) Nr. 11, pp. 2602 - 2620.e10

Online Full Text: dx.doi.org/
Rodriguez-Martin, Bernardo; Schadendorf, Dirk; Campbell, Peter J.

Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

In: Nature Genetics Vol. 55 (2023) Nr. 6, 1080

Online Full Text: dx.doi.org/ (Open Access)
Thiele, Holger; Zeymer, Uwe; Akin, Ibrahim; Behnes, Michael; Rassaf, Tienush; Mahabadi, Amir Abbas; Lehmann, Ralf; Eitel, Ingo; Graf, Tobias; Seidler, Tim; Schuster, Andreas; Skurk, Carsten; Duerschmied, Daniel; Clemmensen, Peter; Hennersdorf, Marcus; Fichtlscherer, Stephan; Voigt, Ingo; Seyfarth, Melchior; John, Stefan; Ewen, Sebastian; Linke, Axel; Tigges, Eike; Nordbeck, Peter; Bruch, Leonhard; Jung, Christian; Franz, Jutta; Lauten, Philipp; Goslar, Tomaz; Feistritzer, Hans-Josef; Pöss, Janine; Kirchhof, Eva; Ouarrak, Taoufik; Schneider, Steffen; Desch, Steffen; Freund, Anne

Extracorporeal Life Support in Infarct-Related Cardiogenic Shock

In: The New England Journal of Medicine Vol. 389 (2023) Nr. 14, pp. 1286 - 1297

Online Full Text: dx.doi.org/
Dewald, Felix; Pirkl, Martin; Paluschinski, Martha; Kühn, Joachim; Elsner, Carina; Schulte, Bianca; Knüfer, Jacqueline; Ahmadov, Elvin; Schlotz, Maike; Oral, Göksu; Bernhard, Michael; Michael, Mark; Luxenburger, Maura; Andrée, Marcel; Hennies, Marc Tim; Hafezi, Wali; Müller, Marlin Maybrit; Kümpers, Philipp; Risse, Joachim; Kill, Clemens; Manegold, Randi Katrin; von Frantzki, Ute; Richter, Enrico; Emmert, Dorian; Monzon-Posadas, Werner O.; Gräff, Ingo; Kogej, Monika; Büning, Antonia; Baum, Maximilian; Teipel, Finn; Mochtarzadeh, Babak; Wolff, Martin; Gruell, Henning; Di Cristanziano, Veronica; Burst, Volker; Streeck, Hendrik; Dittmer, Ulf; Ludwig, Stephan; Timm, Jörg; Klein, Florian

Impaired humoral immunity to BQ.1.1 in convalescent and vaccinated patients

In: Nature Communications Vol. 14 (2023) Nr. 1, 2835

Online Full Text: dx.doi.org/ (Open Access)
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Neutrophil Conversion to a Tumor-Killing Phenotype Underpins Effective Microbial Therapy

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Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification

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Zoledronic Acid Add-on Therapy for Standard-Risk Ewing Sarcoma Patients in the Ewing 2008R1 Trial

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Impact of TP53 on outcome of patients with myelofibrosis undergoing hematopoietic stem cell transplantation

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Transcriptional reprogramming by mutated IRF4 in lymphoma

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Next generation radiotheranostics promoting precision medicine

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The landscape of viral associations in human cancers

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The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latency

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Neoadjuvant immunotherapy for melanoma is now ready for clinical practice

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Health-related quality of life and pain outcomes with [¹⁷⁷Lu]Lu-PSMA-617 plus standard of care versus standard of care in patients with metastatic castration-resistant prostate cancer (VISION) : a multicentre, open-label, randomised, phase 3 trial

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Circulating tumor DNA analysis of the phase III VOYAGER trial : KIT mutational landscape and outcomes in patients with advanced gastrointestinal stromal tumor treated with avapritinib or regorafenib

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Allogeneic hematopoietic stem cell transplantation for NK/T-cell lymphoma : An international collaborative analysis

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Author Correction: Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis

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HLA class II loss and JAK1/2 deficiency coevolve in melanoma leading to CD4 T cell and IFNγ cross-resistance

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N1 versus N2 and PMN-MDSC : A critical appraisal of current concepts on tumor-associated neutrophils and new directions for human oncology

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Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s disease

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Sotorasib in KRAS p.G12C-Mutated Advanced Pancreatic Cancer

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Molecular heterogeneity and commonalities in pancreatic cancer precursors with gastric and intestinal phenotype

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Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy

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Designing clinical trials based on modern imaging and metastasis-directed treatments in patients with oligometastatic breast cancer : a consensus recommendation from the EORTC Imaging and Breast Cancer Groups

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Erdafitinib in patients with advanced solid tumours with FGFR alterations (RAGNAR) : An international, single-arm, phase 2 study

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The German Network for Personalized Medicine to enhance patient care and translational research

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The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity

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Hemizygous CDKN2A deletion confers worse survival outcomes in IDHmut-noncodel gliomas

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Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma

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Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis

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LAMC2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer Growth

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The transcriptional and regulatory identity of erythropoietin producing cells

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Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

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Pelletier, Abigaelle; Nelius, Eric; Fan, Zheng; Khatchatourova, Ekaterina; Alvarado-Diaz, Abdiel; He, Jingyi; Krzywinska, Ewelina; Sobecki, Michal; Nagarajan, Shunmugam; Kerdiles, Yann; Fandrey, Joachim; Gotthardt, Dagmar; Sexl, Veronika; de Bock, Katrien; Stockmann, Christian

Resting natural killer cell homeostasis relies on tryptophan/NAD⁺ metabolism and HIF-1α

In: EMBO Reports (2023) e56156

Online Full Text: dx.doi.org/ (Open Access)
Kebir, Sied; Ullrich, Vivien; Berger, Pia; Dobersalske, Celia; Langer, Sarah; Rauschenbach, Laurèl; Trageser, Daniel; Till, Andreas; Lorbeer, Franziska K.; Wieland, Anja; Wilhelm-Buchstab, Timo; Ahmad, Ashar; Fröhlich, Holger; Cima, Igor; Prasad, Shruthi; Matschke, Johann; Jendrossek, Verena; Remke, Marc; Grüner, Barbara M.; Rösch, Alexander; Siveke, Jens; Herold-Mende, Christel; Blau, Tobias; Keyvani, Kathy; van Landeghem, Frank K H; Pietsch, Torsten; Felsberg, Jörg; Reifenberger, Guido; Weller, Michael; Sure, Ulrich; Brüstle, Oliver; Simon, Matthias; Glas, Martin; Scheffler, Björn

A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma

In: Clinical Cancer Research Vol. 29 (2023) Nr. 2, pp. 488 - 500

Online Full Text: dx.doi.org/ (Open Access)
de Langen, Adrianus Johannes; Johnson, Melissa L; Mazieres, Julien; Dingemans, Anne-Marie C; Mountzios, Giannis; Pless, Miklos; Wolf, Jürgen; Schuler, Martin; Lena, Hervé; Skoulidis, Ferdinandos; Yoneshima, Yasuto; Kim, Sang-We; Linardou, Helena; Novello, Silvia; van der Wekken, Anthonie J; Chen, Yuanbin; Peters, Solange; Felip, Enriqueta; Solomon, Benjamin J; Ramalingam, Suresh S.; Dooms, Christophe; Lindsay, Colin R; Ferreira, Carlos Gil; Blais, Normand; Obiozor, Cynthia C; Wang, Yang; Mehta, Bhakti; Varrieur, Tracy; Ngarmchamnanrith, Gataree; Stollenwerk, Björn; Waterhouse, David; Paz-Ares, Luis

Sotorasib versus docetaxel for previously treated non-small-cell lung cancer with KRASG¹²C mutation : a randomised, open-label, phase 3 trial

In: Lancet Vol. 401 (2023) Nr. 10378, pp. 733 - 746

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Hose, Matthias; Günther, Anne; Naser, Eyad; Schumacher, Fabian; Schönberger, Tina; Falkenstein, Julia; Papadamakis, Athanasios; Kleuser, Burkhard; Becker, Katrin Anne; Gulbins, Erich; Haimovitz-Friedman, Adriana; Buer, Jan; Westendorf, Astrid; Hansen, Wiebke

Cell-intrinsic ceramides determine T cell function during melanoma progression

In: eLife Vol. 11 (2022) e83073

Online Full Text: dx.doi.org/ (Open Access)
Seifert, Robert; Kersting, David; Rischpler, Christoph; Sandach, Patrick; Ferdinandus, Justin; Fendler, Wolfgang; Rahbar, Kambiz; Weckesser, Matthias; Umutlu, Lale; Hanoun, Christine; Hüttmann, Andreas; Reinhardt, Hans Christian; von Tresckow, Bastian; Herrmann, Ken; Dührsen, Ulrich; Schäfers, Michael

Interim FDG-PET analysis to identify patients with aggressive non-Hodgkin lymphoma who benefit from treatment intensification : A post-hoc analysis of the PETAL trial

In: Leukemia Vol. 36 (2022) Nr. 12, pp. 2845 - 2852

Online Full Text: dx.doi.org/ (Open Access)
Stejerean-Todoran, Ioana; Zimmermann, Katharina; Gibhardt, Christine S; Vultur, Adina; Ickes, Christian; Shannan, Batool; Bonilla del Rio, Zuriñe; Wölling, Anna; Cappello, Sabrina; Sung, Hsu-Min; Shumanska, Magdalena; Zhang, Xin; Nanadikar, Maithily; Latif, Muhammad U; Wittek, Anna; Lange, Felix; Waters, Andrea; Brafford, Patricia; Wilting, Jörg; Urlaub, Henning; Katschinski, Dörthe M; Rehling, Peter; Lenz, Christof; Jakobs, Stefan; Ellenrieder, Volker; Rösch, Alexander; Schön, Michael P; Herlyn, Meenhard; Stanisz, Hedwig; Bogeski, Ivan

MCU controls melanoma progression through a redox-controlled phenotype switch

In: EMBO Reports Vol. 23 (2022) Nr. 11, e54746

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Heger, Jan-Michel; Mattlener, Julia; Gödel, Philipp; Balke-Want, Hyatt; Sieg, Noëlle; Kutsch, Nadine; Becker, Kerstin; Weiss, Jonathan; Reinhardt, Christian; Hallek, Michael; Borchmann, Peter; von Tresckow, Bastian; Borchmann, Sven

Noninvasive, Dynamic Risk Profiling of Primary Central Nervous System Lymphoma By Peripheral Blood Ctdna-Sequencing

In: Blood Vol. 140 (2022) Nr. Suppl. 1, pp. 3537 - 3538

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Küppers, Ralf; Schadendorf, Dirk; Macintyre, Geoff; PCAWG Consortium

Author Correction : Inferring structural variant cancer cell fraction

In: Nature Communications Vol. 13 (2022) 7568

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Küppers, Ralf; Schadendorf, Dirk; Stein, Lincoln D.; PCAWG Consortium

Author Correction : A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

In: Nature Communications Vol. 13 (2022) 7573

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Küppers, Ralf; Schadendorf, Dirk; Creighton, Chad J.; PCAWG Consortium

Author Correction : High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

In: Nature Communications Vol. 13 (2022) 7572

Online Full Text: dx.doi.org/ (Open Access)
Thomalla, D.; Beckmann, L.; Grimm, C.; Oliverio, M.; Meder, L.; Herling, C.D.; Nieper, P.; Feldmann, T.; Merkel, O.; Lorsy, E.; da Palma Guerreiro, A.; von Jan, J.; Kisis, I.; Wasserburger, E.; Claasen, J.; Faitschuk-Meyer, E.; Altmüller, J.; Nürnberg, P.; Yang, T.-P.; Lienhard, M.; Herwig, R.; Kreuzer, K.-A.; Pallasch, C.P.; Büttner, R.; Schäfer, S.C.; Hartley, J.; Abken, H.; Peifer, M.; Kashkar, H.; Knittel, G.; Eichhorst, B.; Ullrich, R.T.; Herling, M.; Reinhardt, Christian; Hallek, M.; Schweiger, M.R.; Frenzel, L.P.

Deregulation and epigenetic modification of BCL2-family genes cause resistance to venetoclax in hematologic malignancies

In: Blood Vol. 140 (2022) Nr. 20, pp. 2113 - 2126

Online Full Text: dx.doi.org/ (Open Access)
Bazarbachi, Ali; Labopin, Myriam; Aljurf, Mahmoud; Niittyvuopio, Riitta; Balsat, Marie; Blaise, Didier; Yakoub-Agha, Ibrahim; Grassi, Anna; Reinhardt, Hans Christian; Lenhoff, Stig; Jindra, Pavel; Passweg, Jakob; Abou Dalle, Iman; Stadler, Michael; Lioure, Bruno; Ceballos, Patrice; Brissot, Eolia; Giebel, Sebastian; Nagler, Arnon; Schmid, Christoph; Mohty, Mohamad

20-Year Steady Increase in Survival of Adult Patients with Relapsed Philadelphia-Positive Acute Lymphoblastic Leukemia Post Allogeneic Hematopoietic Cell Transplantation

In: Clinical Cancer Research Vol. 28 (2022) Nr. 5, pp. 1004 - 1012

Online Full Text: dx.doi.org/ (Open Access)
Livingstone, Elisabeth; Zimmer, Lisa; Hassel, Jessica C.; Fluck, Michael; Eigentler, Thomas K.; Loquai, Carmen; Haferkamp, Sebastian; Gutzmer, Ralf; Meier, Friedegund; Mohr, Peter; Hauschild, Axel; Schilling, Bastian; Menzer, Christian; Kiecker, Felix; Dippel, Edgar; Rösch, Alexander; Ziemer, Mirjana; Conrad, Beate; Körner, Silvia; Windemuth-Kieselbach, Christine; Schwarz, Leonora; Garbe, Claus; Becker, Jürgen C.; Schadendorf, Dirk; Simon, Jan-Christoph; Herbst, Rudolf A.; Berking, Carola; Utikal, Jochen; Sell, Sabine; Martens, Uwe M.; Terheyden, Patrick; Stadler, Rudolf

Adjuvant nivolumab plus ipilimumab or nivolumab alone versus placebo in patients with resected stage IV melanoma with no evidence of disease (IMMUNED) : Final results of a randomised, double-blind, phase 2 trial

In: Lancet Vol. 400 (2022) Nr. 10358, pp. 1117 - 1129

Online Full Text: dx.doi.org/
Frede, Annika; Czarnewski, Paulo; Monasterio, Gustavo; Tripathi, Kumar P.; Bejarano, David A.; Ramirez Flores, Ricardo O.; Sorini, Chiara; Larsson, Ludvig; Luo, Xinxin; Geerlings, Laura; Novella-Rausell, Claudio; Zagami, Chiara; Kuiper, Raoul; Morales, Rodrigo A.; Castillo, Francisca; Hunt, Matthew; Mariano, Livia Lacerda; Hu, Yue O.O.; Engblom, Camilla; Lennon-Duménil, Ana-Maria; Mittenzwei, Romy; Westendorf, Astrid; Hövelmeyer, Nadine; Lundeberg, Joakim; Saez-Rodriguez, Julio; Schlitzer, Andreas; Das, Srustidhar; Villablanca, Eduardo J.

B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing

In: Immunity Vol. 55 (2022) Nr. 12, pp. 2336 - 2351.e12

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Jahn, A.; Rump, A.; Widmann, T.J.; Heining, C.; Horak, P.; Hutter, B.; Paramasivam, N.; Uhrig, S.; Gieldon, L.; Drukewitz, S.; Kübler, A.; Bermudez, M.; Hackmann, K.; Porrmann, J.; Wagner, J.; Arlt, M.; Franke, M.; Fischer, J.; Kowalzyk, Z.; William, D.; Weth, V.; Oster, S.; Fröhlich, M.; Hüllein, J.; Valle González, C.; Kreutzfeldt, S.; Mock, A.; Heilig, C.E.; Lipka, D.B.; Möhrmann, L.; Hanf, D.; Oleś, M.; Teleanu, V.; Allgäuer, M.; Ruhnke, L.; Kutz, O.; Knurr, A.; Laßmann, A.; Endris, V.; Neumann, O.; Penzel, R.; Beck, K.; Richter, D.; Winter, U.; Wolf, S.; Pfütze, K.; Geörg, C.; Meißburger, B.; Buchhalter, I.; Augustin, M.; Aulitzky, W.E.; Hohenberger, P.; Kroiss, M.; Schirmacher, P.; Schlenk, R.F.; Keilholz, U.; Klauschen, F.; Folprecht, G.; Bauer, Sebastian; Siveke, Jens; Brandts, C.H.; Kindler, T.; Boerries, M.; Illert, A.L.; von Bubnoff, N.; Jost, P.J.; Metzeler, K.H.; Bitzer, M.; Schulze-Osthoff, K.; von Kalle, C.; Brors, B.; Stenzinger, A.; Weichert, W.; Hübschmann, D.; Fröhling, S.; Glimm, H.; Schröck, E.; Klink, B.

Comprehensive cancer predisposition testing within the prospective MASTER trial identifies hereditary cancer patients and supports treatment decisions for rare cancers

In: Annals of Oncology Vol. 33 (2022) Nr. 11, pp. 1186 - 1199

Online Full Text: dx.doi.org/ (Open Access)
Long, Georgina V; Luke, Jason J; Khattak, Muhammad A; de la Cruz Merino, Luis; Del Vecchio, Michele; Rutkowski, Piotr; Spagnolo, Francesco; Mackiewicz, Jacek; Chiarion-Sileni, Vanna; Kirkwood, John M; Robert, Caroline; Grob, Jean-Jacques; de Galitiis, Federica; Schadendorf, Dirk; Carlino, Matteo S; Mohr, Peter; Dummer, Reinhard; Gershenwald, Jeffrey E; Yoon, Charles H; Wu, Xi Lawrence; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Eggermont, Alexander M M; Ascierto, Paolo A

Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716) : distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial

In: The Lancet Oncology Vol. 23 (2022) Nr. 11, pp. 1378 - 1388

Online Full Text: dx.doi.org/
Fendler, Wolfgang; Pabst, Kim M.; Kessler, Lukas; Fragoso Costa, Pedro; Ferdinandus, Justin; Weber, Manuel; Lippert, Maria; Lückerath, Katharina; Umutlu, Lale; Kostbade, Karina; Mavroeidi, Ilektra A.; Schuler, Martin; Ahrens, Marit; Rischpler, Christoph; Bauer, Sebastian; Herrmann, Ken; Siveke, Jens; Hamacher, Rainer

Safety and Efficacy of 90Y-FAPI-46 Radioligand Therapy in Patients with Advanced Sarcoma and Other Cancer Entities

In: Clinical Cancer Research Vol. 28 (2022) Nr. 19, pp. 4346 - 4353

Online Full Text: dx.doi.org/ (Open Access)
Menzies, Alexander M.; da Silva, Ines Pires; Trojaniello, Claudia; Vieu, Elisabeth; Amaria, Rodabe N.; Zimmer, Lisa; Lo, Serigne N.; Burton, Elizabeth M.; Tawbi, Hussein A.; Schadendorf, Dirk; Grob, Jean J.; Ascierto, Paolo A.; Long, Georgina V.; Pires da Silva, Ines

CTLA-4 Blockade Resistance after Relatlimab and Nivolumab

In: The New England Journal of Medicine Vol. 386 (2022) Nr. 17, pp. 1668 - 1669

Online Full Text: dx.doi.org/ (Open Access)
Bretheau, Floriane; Castellanos-Molina, Adrian; Bélanger, Dominic; Kusik, Maxime; Mailhot, Benoit; Boisvert, Ana; Vallières, Nicolas; Lessard, Martine; Gunzer, Matthias; Liu, Xiaoyu; Boilard, Éric; Quan, Ning; Lacroix, Steve

The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury

In: Nature Communications Vol. 13 (2022) Nr. 1, 5786

Online Full Text: dx.doi.org/ (Open Access)
Günther, Anne; Hose, Matthias; Abberger, Hanna; Schumacher, Fabian; Veith, Ylva; Kleuser, Burkhard; Matuschewski, Kai; Lang, Karl Sebastian; Gulbins, Erich; Buer, Jan; Westendorf, Astrid M.; Hansen, Wiebke

The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis

In: eLife Vol. 11 (2022) e77975

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Arrieta-Bolaños, Esteban; Crivello, Pietro; He, Meilun; Wang, Tao; Gadalla, Shahinaz M.; Paczesny, Sophie; Marsh, Steven G.E.; Lee, Stephanie J.; Spellman, Stephen R.; Bolon, Yung-Tsi; Fleischhauer, Katharina

A core group of structurally similar HLA-DPB1 alleles drives permissiveness after hematopoietic cell transplantation

In: Blood Vol. 140 (2022) Nr. 6, pp. 659 - 663

Online Full Text: dx.doi.org/ (Open Access)
Pindzola, Grace M.; Razzaghi, Raud; Tavory, Rachel N.; Nguyen, Hang T.; Morris, Vivian M.; Li, Moyi; Agarwal, Shreya; Huang, Bonnie; Okada, Takaharu; Reinhardt, Christian; Knittel, Gero; Kashkar, Hamid; Young, Ryan M.; Pittaluga, Stefania; Muppidi, Jagan R.

Aberrant expansion of spontaneous splenic germinal centers induced by hallmark genetic lesions of aggressive lymphoma

In: Blood Vol. 140 (2022) Nr. 10, pp. 1119 - 1131

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk; Morris, Quaid D.; PCAWG Consortium

Author Correction : Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

In: Nature Communications Vol. 13 (2022) 7567

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk; Reimand, Jüri; PCAWG Consortium

Author Correction : Pathway and network analysis of more than 2500 whole cancer genomes

In: Nature Communications Vol. 13 (2022) 7566

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk; Feuerbach, Lars; PCAWG Consortium

Author Correction : Genomic footprints of activated telomere maintenance mechanisms in cancer

In: Nature Communications Vol. 13 (2022) 7574

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk; Reimand, Jüri; PCAWG Drivers and Functional Interpretation Working Group; PCAWG Consortium

Author Correction : Integrative pathway enrichment analysis of multivariate omics data

In: Nature Communications Vol. 13 (2022) 7570

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk; Bristow, Robert G.; Boutros, Paul C.; PCAWG Consortium

Author Correction : Divergent mutational processes distinguish hypoxic and normoxic tumours

In: Nature Communications Vol. 13 (2022) 7569

Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Schadendorf, Dirk; Shuai, Shimin; Stein, Lincoln D.; PCAWG Drivers and Functional Interpretation Working Group; PCAWG Consortium

Author Correction : Combined burden and functional impact tests for cancer driver discovery using DriverPower

In: Nature Communications Vol. 13 (2022) 7571

Online Full Text: dx.doi.org/ (Open Access)
Weber, Manuel; Kersting, David; Riemann, Burkhard; Brandenburg, Tim; Führer, Dagmar; Grünwald, Frank; Kreissl, Michael C.; Dralle, Henning; Weber, Frank; Schmid, Kurt Werner; Herrmann, Ken; Jentzen, Walter; Grafe, Hong; Rischpler, Christoph; Theurer, Sarah; Bockisch, Andreas; Nagarajah, James; Fendler, Wolfgang

Enhancing Radioiodine Incorporation into Radioiodine-Refractory Thyroid Cancer with MAPK Inhibition (ERRITI) : A Single-Center Prospective Two-Arm Study

In: Clinical Cancer Research Vol. 28 (2022) Nr. 19, pp. 4194 - 4202

Online Full Text: dx.doi.org/ (Open Access)
Abdul Razak, Albiruni R.; Bauer, Sebastian; Suarez, Cristina; Lin, Chia-Chi; Quek, Richard; Hütter-Krönke, Marie Luise; Cubedo, Ricardo; Ferretti, Stephane; Guerreiro, Nelson; Jullion, Astrid; Orlando, Elena J.; Clementi, Giorgia; Dejmek, Janna Sand; Halilovic, Ensar; Fabre, Claire; Blay, Jean-Yves; Italiano, Antoine; Sand Dejmek, Janna

Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma : Results from a Proof-of-Concept, Phase Ib Study

In: Clinical Cancer Research Vol. 28 (2022) Nr. 6, pp. 1087 - 1097

Online Full Text: dx.doi.org/ (Open Access)
Izquierdo, Elena; Vorholt, Daniela; Blakemore, Stuart; Sackey, Benedict; Nolte, Janica L.; Barbarino, Verena; Schmitz, Jan; Nickel, Nadine; Bachurski, Daniel; Lobastova, Liudmila; Nikolic, Milos; Michalik, Michael; Brinker, Reinhild; Merkel, Olaf; Franitza, Marek; Georgomanolis, Theodoros; Neuhaus, René; Koch, Maximilian; Nasada, Niklas; Knittel, Gero; Chapuy, Björn; Ludwig, Nicole; Meese, Eckart; Frenzel, Lukas; Reinhardt, Hans Christian; Peifer, Martin; Rebollido-Rios, Rocio; Bruns, Heiko; Krüger, Marcus; Hallek, Michael; Pallasch, Christian P.

Extracellular vesicles and PD-L1 suppress macrophages, inducing therapy resistance in TP53-deficient B-cell malignancies

In: Blood Vol. 139 (2022) Nr. 25, pp. 3617 - 3629

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Pylaeva, Ekaterina; Korschunow, Georg; Spyra, Ilona; Bordbari, Sharareh; Siakaeva, Elena; Ozel, Irem; Domnich, Maksim; Squire, Anthony; Hasenberg, Anja; Thangavelu, Kruthika; Hussain, Timon; Goetz, Moritz; Lang, Karl S.; Gunzer, Matthias; Hansen, Wiebke; Buer, Jan; Bankfalvi, Agnes; Lang, Stephan; Jablonska, Jadwiga

During early stages of cancer, neutrophils initiate anti-tumor immune responses in tumor-draining lymph nodes

In: Cell Reports Vol. 40 (2022) Nr. 7, 111171

Online Full Text: dx.doi.org/ (Open Access)
Contreras, Whendy; Wiesehöfer, Caroline; Schreier, Dora; Leinung, Nadja; Peche, Petra; Wennemuth, Gunther; Gentzel, Marc; Schröder, Bernd; Mentrup, Torben

C11orf94/Frey is a key regulator for male fertility by controlling Izumo1 complex assembly

In: Science Advances Vol. 8 (2022) Nr. 32, eabo6049

Online Full Text: dx.doi.org/ (Open Access)
Zhao, Yanhe; Wang, Huafeng; Wiesehoefer, Caroline; Shah, Naman B.; Reetz, Evan; Hwang, Jae Yeon; Huang, Xiaofang; Wang, Tse-en; Lishko, Polina V.; Davies, Karen M.; Wennemuth, Gunther; Nicastro, Daniela; Chung, Jean-Ju

3D structure and in situ arrangements of CatSper channel in the sperm flagellum

In: Nature Communications Vol. 13 (2022) Nr. 1, 3439

Online Full Text: dx.doi.org/ (Open Access)
Gross, Neil D.; Miller, David M.; Khushalani, Nikhil I.; Divi, Vasu; Ruiz, Emily S.; Lipson, Evan J.; Meier, Friedegund; Su, Yungpo B.; Swiecicki, Paul L.; Atlas, Jennifer; Geiger, Jessica L.; Hauschild, Axel; Choe, Jennifer H.; Hughes, Brett G.M.; Schadendorf, Dirk; Patel, Vishal A.; Homsi, Jade; Taube, Janis M.; Lim, Annette M.; Ferrarotto, Renata; Kaufman, Howard L.; Seebach, Frank; Lowy, Israel; Yoo, Suk-Young; Mathias, Melissa; Fenech, Keilah; Han, Hyunsil; Fury, Matthew G.; Rischin, Danny

Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma

In: The New England Journal of Medicine Vol. 387 (2022) Nr. 17, pp. 1557 - 1568

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Totzeck, Matthias; Michel, Lars; Lin, Yi; Herrmann, Joerg; Rassaf, Tienush

Cardiotoxicity from chimeric antigen receptor-T cell therapy for advanced malignancies

In: European Heart Journal Vol. 43 (2022) Nr. 20, pp. 1928 - 1940

Online Full Text: dx.doi.org/ (Open Access)
Subbiah, Vivek; Cassier, Philippe A.; Siena, Salvatore; Garralda, Elena; Paz-Ares, Luis; Garrido, Pilar; Nadal, Ernest; Vuky, Jacqueline; Lopes, Gilberto; Kalemkerian, Gregory P.; Bowles, Daniel W.; Seetharam, Mahesh; Chang, Jianhua; Zhang, Hui; Green, Jennifer; Zalutskaya, Alena; Schuler, Martin; Fan, Yun; Curigliano, Giuseppe

Pan-cancer efficacy of pralsetinib in patients with RET fusion–positive solid tumors from the phase 1/2 ARROW trial

In: Nature Medicine Vol. 28 (2022) Nr. 8, pp. 1640 - 1645

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Schirrmann, Ronja; Erkelenz, Michael; Lamers, Kim; Sritharan, Oliver; Nachev, Milen; Sures, Bernd; Schlücker, Sebastian; Brandau, Sven

Gold Nanorods Induce Endoplasmic Reticulum Stress and Autocrine Inflammatory Activation in Human Neutrophils

In: ACS Nano Vol. 16 (2022) Nr. 7, pp. 11011 - 11026

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Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Jürgen; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodríguez-López, José Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Rösch, Alexander

Persister state-directed transitioning and vulnerability in melanoma

In: Nature Communications Vol. 13 (2022) Nr. 1, 3055

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Pijnappel, Esther N.; Suurmeijer, J. Annelie; Groot Koerkamp, Bas; Kos, Milan; Siveke, Jens; Salvia, Roberto; Ghaneh, Paula; van Eijck, Casper H. J.; van Etten-Jamaludin, Faridi S.; Abrams, Ross; Brasiūnienė, Birute; Büchler, Markus W.; Casadei, Riccardo; van Laethem, Jean-Luc; Berlin, Jordan; Boku, Narikazu; Conroy, Thierry; Golcher, Henriette; Sinn, Marianne; Neoptolemos, John P.; van Tienhoven, Geertjan; Besselink, Marc G.; Wilmink, Johanna W.; van Laarhoven, Hanneke W. M.

Consensus Statement on Mandatory Measurements for Pancreatic Cancer Trials for Patients with Resectable or Borderline Resectable Disease (COMM-PACT-RB) : A Systematic Review and Delphi Consensus Statement

In: JAMA Oncology Vol. 8 (2022) Nr. 6, pp. 929 - 937

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Luke, Jason J.; Rutkowski, Piotr; Queirolo, Paola; Del Vecchio, Michele; Mackiewicz, Jacek; Chiarion-Sileni, Vanna; de la Cruz Merino, Luis; Khattak, Muhammad A.; Schadendorf, Dirk; Long, Georgina V.; Ascierto, Paolo A.; Mandala, Mario; De Galitiis, Federica; Haydon, Andrew; Dummer, Reinhard; Grob, Jean-Jacques; Robert, Caroline; Carlino, Matteo S.; Mohr, Peter; Poklepovic, Andrew; Sondak, Vernon K.; Scolyer, Richard A.; Kirkwood, John M.; Chen, Ke; Diede, Scott J.; Ahsan, Sama; Ibrahim, Nageatte; Eggermont, Alexander M. M.

Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716) : a randomised, double-blind, phase 3 trial

In: Lancet Vol. 399 (2022) Nr. 10336, pp. 1718 - 1729

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Vincenzi, Bruno; Napolitano, Andrea; Fiocco, Marta; Mir, Olivier; Rutkowski, Piotr; Blay, Jean-Yves; Reichardt, Peter; Joensuu, Heikki; Fumagalli, Elena; Gennatas, Spyridon; Hindi, Nadia; Nannini, Margherita; Ceruso, Mariella Spalato; Italiano, Antoine; Grignani, Giovanni; Brunello, Antonella; Gasperoni, Silvia; De Pas, Tommaso; Badalamenti, Giuseppe; Pantaleo, Maria A.; Van Houdt, Winan J.; IJzerman, Nikki S.; Steeghs, Neeltje; Gelderblom, Hans; Desar, Ingrid M.E.; Falkenhorst, Johanna; Silletta, Marianna; Sbaraglia, Marta; Tonini, Giuseppe; Martin-Brot, Javier; Hohenberger, Peter; Le Cesne, Axel; Jones, Robin L.; Dei Tos, Angelo P.; Gronchi, Alessandro; Bauer, Sebastian; Casali, Paolo G.

Adjuvant Imatinib in Patients with GIST Harboring Exon 9 KIT Mutations : Results from a Multi-institutional European Retrospective Study

In: Clinical Cancer Research Vol. 28 (2022) Nr. 8, pp. 1672 - 1679

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Krebs, Matthew G.; Malapelle, Umberto; André, Fabrice; Paz-Ares, Luis; Schuler, Martin; Thomas, David M.; Vainer, Gilad; Yoshino, Takayuki; Rolfo, Christian

Practical Considerations for the Use of Circulating Tumor DNA in the Treatment of Patients With Cancer

In: JAMA Oncology Vol. 8 (2022) Nr. 12, pp. 1830 - 1839

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Schuler, Martin; Zimmer, Lisa; Kim, Kevin B.; Sosman, Jeffrey A.; Ascierto, Paolo A.; Postow, Michael A.; De Vos, Filip Y.F.L.; van Herpen, Carla M.L.; Carlino, Matteo S.; Johnson, Douglas B.; Berking, Carola; Reddy, Micaela B.; Harney, Allison S.; Berlin, Jordan D.; Amaria, Rodabe N.

Phase Ib/II Trial of Ribociclib in Combination with Binimetinib in Patients with NRAS-mutant Melanoma

In: Clinical Cancer Research Vol. 28 (2022) Nr. 14, pp. 3002 - 3010

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Rohlfing, Anne-Katrin; Kolb, Kyra; Sigle, Manuel; Ziegler, Melanie; Bild, Alexander; Münzer, Patrick; Sudmann, Jessica; Dicenta, Valerie; Harm, Tobias; Manke, Mailin-Christin; Geue, Sascha; Kremser, Marcel; Chatterjee, Madhumita; Liang, Chunguang; von Eysmondt, Hendrik; Dandekar, Thomas; Heinzmann, David; Günter, Manina; von Ungern-Sternberg, Saskia; Büttcher, Manuela; Castor, Tatsiana; Mencl, Stine; Langhauser, Friederike; Sies, Katharina; Ashour, Diyaa; Beker, Mustafa Caglar; Lämmerhofer, Michael; Autenrieth, Stella E.; Schäffer, Tilman E.; Laufer, Stefan; Szklanna, Paulina; Maguire, Patricia; Heikenwalder, Matthias; Müller, Karin Anne Lydia; Hermann, Dirk M.; Kilic, Ertugrul; Stumm, Ralf; Ramos, Gustavo; Kleinschnitz, Christoph; Borst, Oliver; Langer, Harald F.; Rath, Dominik; Gawaz, Meinrad

ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury

In: Nature Communications Vol. 13 (2022) Nr. 1, 1823

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Beuker, Carolin; Schafflick, David; Strecker, Jan-Kolja; Heming, Michael; Li, Xiaolin; Wolbert, Jolien; Schmidt-Pogoda, Antje; Thomas, Christian; Kuhlmann, Tanja; Aranda-Pardos, Irene; A-Gonzalez, Noelia; Kumar, Praveen Ashok; Werner, Yves; Kilic, Ertugrul; Hermann, Dirk M.; Wiendl, Heinz; Stumm, Ralf; Hörste, Gerd Meyer Zu; Minnerup, Jens

Stroke induces disease-specific myeloid cells in the brain parenchyma and pia

In: Nature Communications Vol. 13 (2022) Nr. 1, 945

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Tawbi, Hussein A.; Schadendorf, Dirk; Lipson, Evan J.; Ascierto, Paolo A.; Matamala, Luis; Castillo Gutiérrez, Erika; Rutkowski, Piotr; Gogas, Helen J.; Lao, Christopher D.; De Menezes, Juliana Janoski; Dalle, Stéphane; Arance, Ana; Grob, Jean-Jacques; Srivastava, Shivani; Abaskharoun, Mena; Hamilton, Melissa; Keidel, Sarah; Simonsen, Katy L.; Sobiesk, Anne Marie; Li, Bin; Hodi, F. Stephen; Long, Georgina V.

Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma

In: The New England Journal of Medicine Vol. 386 (2022) Nr. 1, pp. 24 - 34

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Casali, P. G.; Blay, J. Y.; Bauer, Sebastian; Stacchiotti, S.; et al.

Gastrointestinal stromal tumours : ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up

In: Annals of Oncology Vol. 33 (2022) Nr. 1, pp. 20 - 33

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Stein, Eytan M.; DeAngelo, Daniel J.; Chromik, Jörg; Chatterjee, Manik; Bauer, Sebastian; Lin, Chia-Chi; Suarez, Cristina; de Vos, Filip; Steeghs, Neeltje; Cassier, Philippe A.; Tai, David; Kiladjian, Jean-Jacques; Yamamoto, Noboru; Mous, Rogier; Esteve, Jordi; Minami, Hironobu; Ferretti, Stephane; Guerreiro, Nelson; Meille, Christophe; Radhakrishnan, Rajkumar; Pereira, Bernard; Mariconti, Luisa; Halilovic, Ensar; Fabre, Claire; Carpio, Cecilia; Cassier, Phillippe A.

Results from a First-in-Human Phase I Study of Siremadlin (HDM201) in Patients with Advanced Wild-Type TP53 Solid Tumors and Acute Leukemia

In: Clinical Cancer Research Vol. 28 (2022) Nr. 5, pp. 870 - 881

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Michel, Lars; Helfrich, Iris; Hendgen-Cotta, Ulrike Barbara; Mincu, Raluca-Ileana; Korste, Sebastian; Mrotzek, Simone Maria; Spomer, Armin; Odersky, Andrea; Rischpler, Christoph; Herrmann, Ken; Umutlu, Lale; Coman, Cristina; Ahrends, Robert; Sickmann, Albert; Löffek, Stefanie; Livingstone, Elisabeth; Ugurel, Selma; Zimmer, Lisa; Gunzer, Matthias; Schadendorf, Dirk; Totzeck, Matthias; Rassaf, Tienush

Targeting early stages of cardiotoxicity from anti-PD1 immune checkpoint inhibitor therapy

In: European Heart Journal Vol. 43 (2022) Nr. 4, pp. 316 - 329

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Lüdike, Peter; Heusch, Gerd; Rassaf, Tienush

The RUHR Heart Failure Network : Improved heart failure care in a metropolitan area

In: European Heart Journal Vol. 43 (2022) Nr. 45, pp. 4675 - 4676

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Liu, Wei; Stachura, Paweł; Xu, Haifeng C.; Váraljai, Renáta; Shinde, Prashant; Ganesh, Nikkitha Umesh; Mack, Matthias; Van Lierop, Anke; Huang, Anfei; Sundaram, Balamurugan; Lang, Karl S.; Picard, Daniel; Fischer, Ute; Remke, Marc; Homey, Bernhard; Rösch, Alexander; Häussinger, Dieter; Lang, Philipp A.; Borkhardt, Arndt; Pandyra, Aleksandra A.; Stachura, Pawel; Umesh Ganesh, Nikkitha

BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment

In: Cancer Research Vol. 82 (2022) Nr. 2, pp. 264 - 277

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Bartl, Jasmin; Zanini, Marco; Bernardi, Flavia; Forget, Antoine; Blümel, Lena; Talbot, Julie; Picard, Daniel; Qin, Nan; Cancila, Gabriele; Gao, Qingsong; Nath, Soumav; Koumba, Idriss Mahoungou; Wolter, Marietta; Kuonen, François; Langini, Maike; Beez, Thomas; Munoz, Christopher; Pauck, David; Marquardt, Viktoria; Yu, Hua; Souphron, Judith; Korsch, Mascha; Mölders, Christina; Berger, Daniel; Göbbels, Sarah; Meyer, Frauke-Dorothee; Scheffler, Björn; Rotblat, Barak; Diederichs, Sven; Ramaswamy, Vijay; Suzuki, Hiromishi; Oro, Anthony; Stühler, Kai; Stefanski, Anja; Fischer, Ute; Leprivier, Gabriel; Willbold, Dieter; Steger, Gerhard; Buell, Alexander; Kool, Marcel; Lichter, Peter; Pfister, Stefan M.; Northcott, Paul A.; Taylor, Michael D.; Borkhardt, Arndt; Reifenberger, Guido; Ayrault, Olivier; Remke, Marc

The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors

In: Nature Communications Vol. 13 (2022) Nr. 1, 4061

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Janning, M.; Süptitz, J.; Albers-Leischner, C.; Delpy, P.; Tufman, A.; Velthaus-Rusik, J.-L.; Reck, M.; Jung, A.; Kauffmann-Guerrero, D.; Bonzheim, I.; Brändlein, S.; Hummel, H.-D.; Wiesweg, Marcel; Schildhaus, Hans-Ulrich; Stratmann, J.A.; Sebastian, M.; Alt, J.; Buth, J.; Esposito, I.; Berger, J.; Tögel, L.; Saalfeld, F.C.; Wermke, M.; Merkelbach-Bruse, S.; Hillmer, A.M.; Klauschen, F.; Bokemeyer, C.; Buettner, R.; Wolf, J.; Loges, S.; Simon, Ronald; Sauter, Guido; Volk, Alexander; Neumann, Jens; Weichert, Wilko; Kalhori, Naser; Lüthen, Reinhard; Stöhr, Robert; Schubart, Chistoph; Wacker, Heidemarie; Fuchs, Florian; Hartmann, Nils; Graf, Stefanie; Brandts, Christian; Wild, Peter; Demes, Melanie; Reis, Henning; Rohde, Gernot

Treatment outcome of atypical EGFR mutations in the German National Network Genomic Medicine Lung Cancer (nNGM)

In: Annals of Oncology Vol. 33 (2022) Nr. 6, pp. 602 - 615

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Schniewind, Iñaki; Hadiwikarta, Wahyu Wijaya; Grajek, Julia; Poleszczuk, Jan; Richter, Susan; Peitzsch, Mirko; Müller, Johannes; Klusa, Daria; Beyreuther, Elke; Löck, Steffen; Lühr, Armin; Frosch, Susanne; Groeben, Christer; Sommer, Ulrich; Krause, Mechthild; Dubrovska, Anna; von Neubeck, Cläre; Kurth, Ina; Peitzsch, Claudia

Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity

In: Cell Reports Vol. 38 (2022) Nr. 8, 110422

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Zeng, Ni; Capelle, Christophe M.; Baron, Alexandre; Kobayashi, Takumi; Cire, Severine; Tslaf, Vera; Leonard, Cathy; Coowar, Djalil; Koseki, Haruhiko; Westendorf, Astrid; Buer, Jan; Brenner, Dirk; Krüger, Rejko; Balling, Rudi; Ollert, Markus; Hefeng, Feng Q.

DJ-1 depletion prevents immunoaging in T-cell compartments

In: EMBO Reports Vol. 23 (2022) Nr. 3, e53302

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Hoertel, Nicolas; Sánchez-Rico, Marina; Herrera-Morueco, Juan José; de la Muela, Pedro; Gulbins, Erich; Kornhuber, Johannes; Carpinteiro, Alexander; Becker-Flegler, Katrin; Cougoule, Céline; Limosin, Frédéric

Comorbid medical conditions are a key factor to understand the relationship between psychiatric disorders and COVID-19-related mortality : Results from 49,089 COVID-19 inpatients

In: Molecular Psychiatry Vol. 27 (2022) Nr. 3, pp. 1278 - 1280

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Grüneboom, Anika; Aust, Oliver; Cibir, Zülal; Weber, Flora; Hermann, Dirk M.; Gunzer, Matthias

Imaging innate immunity*

In: Immunological Reviews Vol. 306 (2022) Nr. 1, pp. 293 - 303

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Cheung, Phyllis F.; Yang, JiaJin; Fang, Rui; Borgers, Arianna; Krengel, Kirsten; Stoffel, Anne; Althoff, Kristina; Yip, Chi Wai; Siu, Elaine H. L.; Ng, Linda W. C.; Lang, Karl S.; Cham, Lamin B.; Engel, Daniel Robert; Soun, Camille; Cima, Igor; Scheffler, Björn; Striefler, Jana K.; Sinn, Marianne; Bahra, Marcus; Pelzer, Uwe; Oettle, Helmut; Markus, Peter; Smeets, Esther M. M.; Aarntzen, Erik H. J. G.; Savvatakis, Konstantinos; Liffers, Sven-Thorsten; Lueong, Smiths S.; Neander, Christian; Bazarna, Anna; Zhang, Xin; Paschen, Annette; Crawford, Howard C.; Chan, Anthony W. H.; Cheung, Siu Tim; Siveke, Jens

Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression

In: Nature Communications Vol. 13 (2022) Nr. 1, 156

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Kornhuber, Johannes; Hoertel, Nicolas; Gulbins, Erich

The acid sphingomyelinase/ceramide system in COVID-19

In: Molecular Psychiatry Vol. 27 (2022) Nr. 1, pp. 307 - 314

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Leypoldt, Lisa B.; Besemer, Britta; Asemissen, Anne Marie; Hänel, Mathias; Blau, Igor Wolfgang; Görner, Martin; Ko, Yon-Dschun; Reinhardt, Christian; Staib, Peter; Mann, Christoph; Lutz, Raphael; Munder, Markus; Graeven, Ullrich; Peceny, Rudolf; Salwender, Hans; Jauch, Anna; Zago, Manola; Benner, Axel; Tichy, Diana; Bokemeyer, Carsten; Goldschmidt, Hartmut; Weisel, Katja C.

Isatuximab, carfilzomib, lenalidomide, and dexamethasone (Isa-KRd) in front-line treatment of high-risk multiple myeloma : Interim analysis of the GMMG-CONCEPT trial

In: Leukemia Vol. 36 (2022) Nr. 3, pp. 885 - 888

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Wilke, Anne C.; Doebele, Carmen; Zindel, Alena; Lee, Kwang Seok; Rieke, Sara A.; Ceribelli, Michele; Comoglio, Federico; Phelan, James D.; Wang, James Q.; Pikman, Yana; Jahn, Dominique; Häupl, Björn; Schneider, Constanze; Scheich, Sebastian; Tosto, Frances A.; Bohnenberger, Hanibal; Stauder, Philipp; Schnütgen, Frank; Slabicki, Mikolaj; Coulibaly, Zana A.; Wolf, Sebastian; Bojarczuk, Kamil; Chapuy, Björn; Brandts, Christian H.; Stroebel, Philipp; Lewis, Caroline A.; Engelke, Michael; Xu, Xincheng; Kim, Hahn; Dang, Thanh Hung; Schmitz, Roland; Hodson, Daniel J.; Stegmaier, Kimberly; Urlaub, Henning; Serve, Hubert; Schmitt, Clemens A.; Kreuz, Fernando; Knittel, Gero; Rabinowitz, Joshua D.; Reinhardt, Christian; Vander Heiden, Matthew G.; Thomas, Craig; Staudt, Louis M.; Zenz, Thorsten; Oellerich, Thomas

SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma

In: Blood Vol. 139 (2022) Nr. 4, pp. 538 - 553

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Rodriguez, Sara; Celay, Jon; Goicoechea, Ibai; Jimenez, Cristina; Botta, Cirino; Garcia-Barchino, Maria-José; Garces, Juan-Jose; Larrayoz, Marta; Santos, Susana; Alignani, Diego; Vilas-Zornoza, Amaia; Perez, Cristina; Garate, Sonia; Sarvide, Sarai; Lopez, Aitziber; Reinhardt, Christian; Carrasco, Yolanda R.; Sanchez-Garcia, Isidro; Larrayoz, Maria-Jose; Calasanz, Maria-Jose; Panizo, Carlos; Prosper, Felipe; Lamo-Espinosa, Jose-Maria; Motta, Marina; Tucci, Alessandra; Sacco, Antonio; Gentile, Massimo; Duarte, Sara; Vitoria, Helena; Geraldes, Catarina; Paiva, Artur; Puig, Noemi; Garcia-Sanz, Ramon; Roccaro, Aldo M.; Fuerte, Gema; San Miguel, Jesus F.; Martinez-Climent, Jose-Angel; Paiva, Bruno

Preneoplastic somatic mutations including MYD88L²⁶⁵P in lymphoplasmacytic lymphoma

In: Science Advances Vol. 8 (2022) Nr. 3, eabl4644

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2021

Flümann, Ruth; Rehkämper, Tim; Nieper, Pascal; Pfeiffer, Pauline; Holzem, Alessandra; Klein, Sebastian; Bhatia, Sanil; Kochanek, Moritz; Kisis, Ilmars; Pelzer, Benedikt W.; Ahlert, Heinz; Hauer, Julia; da Palma Guerreiro, Alexandra; Ryan, Jeremy A.; Reimann, Maurice; Riabinska, Arina; Wiederstein, Janica; Krüger, Marcus; Deckert, Martina; Altmüller, Janine; Klatt, Andreas R.; Frenzel, Lukas P.; Pasqualucci, Laura; Béguelin, Wendy; Melnick, Ari M.; Sander, Sandrine; Montesinos-Rongen, Manuel; Brunn, Anna; Lohneis, Philipp; Büttner, Reinhard; Kashkar, Hamid; Borkhardt, Arndt; Letai, Anthony; Persigehl, Thorsten; Peifer, Martin; Schmitt, Clemens A.; Reinhardt, Christian; Knittel, Gero

An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities

In: Cancer Discovery Vol. 2 (2021) Nr. 1, pp. 70 - 91

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Bottomley, Andrew; Coens, Corneel; Mierzynska, Justyna; Blank, Christian U; Mandalà, Mario; Long, Georgina V; Atkinson, Victoria G; Dalle, Stéphane; Haydon, Andrew M; Meshcheryakov, Andrey; Khattak, Adnan; Carlino, Matteo S; Sandhu, Shahneen; Puig, Susana; Ascierto, Paolo A; Larkin, James; Lorigan, Paul C; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Di Giacomo, Anna Maria; van den Eertwegh, Alfonsus J M; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; van Akkooi, Alexander C J; Krepler, Clemens; Ibrahim, Nageatte; Marreaud, Sandrine; Kicinski, Michal; Suciu, Stefan; Robert, Caroline; Eggermont, Alexander M M; Lesimple, Thierry; Maio, Michele; Linette, Gerald; Mortier, Laurent; Svane, Inge Marie; Schachter, Jacob; Brown, Michael; Hersey, Peter; Barrow, Catherine; Kudchadkar, Ragini; Dutriaux, Caroline; Song, Xinni; Quaglino, Pietro; Queirolo, Paola; Meier, Friedegund; Stroyakovskiy, Daniil; Guillot, Bernard; Romero, Pablo Luis Ortiz; Bastholt, Lars; Garbe, Claus; Grange, Florent; Mohr, Peter; Algazi, Alain; Bechter, Oliver; Hernberg, Micaela; Loquai, Carmen; Meiss, Frank; Chiarion Sileni, Vanna; Bar-Sela, Gil; Fitzharris, Bernard; Saiag, Philippe; Arnault, Jean-Philippe; Simon, Jan-Christoph; Stephens, Rosalie; Baurain, Jean-Francois; Lebbe, Célèste; Combemale, Patrick; Dummer, Reinhard; Hauschild, Axel; Parente, Phillip; Yamazaki, Naoya; Milhem, Mohammed; Leccia, Marie-Thérèse; Geoffrois, Lionel; Kretschmer, Lutz; Dunwoodie, Elaine; Walker, John; Lotem, Michal; Hendler, Daniel; Mackiewicz, Andrzej; Sekulovic, Lidija; Dzienis, Marcin; Hospers, Geke A.P.; Siano, Marco; Hassel, Jessica; Corrie, Philippa; Passos, Maria-Jose; Levin, Max; Hoeller, Christoph; Machet, Laurent; Hallmeyer, Sigrun; Waterston, Ashita; Descamps, Vincent; Kiecker, Felix; Aarts, Maureen; Schmidt, Henrik; Raimundo, Ana; Nyakas, Marta; Lacour, Jean-Philippe; Berking, Carola; Ferrucci, Pier Francesco; Jameson, Michael; Kim, Kevin; Yokota, Kenji; Kerger, Joseph; Aubin, François; Groenewegen, Gerard; Kapiteijn, Helena; Boehncke, Wolf-Henning; Utikal, Jochen; Casasola, Richard; Marshall, Ernest; Ferraresi, Virginia; Richtig, Erika; Matkovic, Suzana; Inozume, Takashi; Crook, Timothy; McNeil, Catriona; Kiyohara, Yoshio; Avril, Marie-Francoise; Hein, Rüdiger; Terheyden, Patrick; Nathan, Paul; Aoi, Jun; Skytta, Tanja; Jouary, Thomas; Takenouchi, Tatsuya; Straume, Oddbjorn; Martins, César; Mukhametshina, Guzel

Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial

In: The Lancet Oncology Vol. 22 (2021) Nr. 5, pp. 655 - 664

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Rankin-Turner, Stephanie; Vader, Pieter; O'Driscoll, Lorraine; Giebel, Bernd; Heaney, Liam M.; Davies, Owen G.

A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos

In: Advanced Drug Delivery Reviews Vol. 173 (2021) pp. 479 - 491

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Henneberg, Sophie; Hasenberg, Anja; Maurer, Andreas; Neumann, Franziska; Bornemann, Lea; Gonzalez-Menendez, Irene; Kraus, Andreas; Hasenberg, Mike; Thornton, Christopher R.; Pichler, Bernd J.; Gunzer, Matthias; Beziere, Nicolas

Antibody-guided in vivo imaging of Aspergillus fumigatus lung infections during antifungal azole treatment

In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1707

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van Sorge, Nina M.; Bonsor, Daniel A.; Deng, Liwen; Lindahl, Erik; Schmitt, Verena; Lyndin, Mykola; Schmidt, Alexej; Nilsson, Olof R.; Brizuela, Jaime; Boero, Elena; Sundberg, Eric J.; van Strijp, Jos A. G.; Doran, Kelly S.; Singer, Bernhard B.; Lindahl, Gunnar; McCarthy, Alex J.

Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors

In: The EMBO Journal Vol. 40 (2021) Nr. 7, pp. e106103

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Berger, Marc; Brenner, Thorsten; Hinney, Anke; Witzke, Oliver

Mapping the human genetic architecture of COVID-19

In: Nature Vol. 600 (2021) pp. 472 - 477

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Strauss, S.J.; Frezza, A.M.; Abecassis, N.; Bajpai, J.; Bauer, Sebastian; Biagini, R.; Bielack, S.; Blay, J.Y.; Bolle, S.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Boye, K.; Brennan, B.; Brodowicz, T.; Buonadonna, A.; de Álava, E.; Dei Tos, A.P.; Garcia del Muro, X.; Dufresne, A.; Eriksson, M.; Fagioli, F.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Gaspar, N.; Gasperoni, S.; Gelderblom, H.; Gouin, F.; Grignani, G.; Gronchi, A.; Haas, R.; Hassan, A.B.; Hecker-Nolting, S.; Hindi, N.; Hohenberger, P.; Joensuu, H.; Jones, R.L.; Jungels, C.; Jutte, P.; Kager, L.; Kasper, B.; Kawai, A.; Kopeckova, K.; Krákorová, D.A.; Le Cesne, A.; Le Grange, F.; Legius, E.; Leithner, A.; López Pousa, A.; Martin-Broto, J.; Merimsky, O.; Messiou, C.; Miah, A.B.; Mir, O.; Montemurro, M.; Morland, B.; Morosi, C.; Palmerini, E.; Pantaleo, M.A.; Piana, R.; Piperno-Neumann, S.; Reichardt, P.; Rutkowski, P.; Safwat, A.A.; Sangalli, C.; Sbaraglia, M.; Scheipl, S.; Schöffski, P.; Sleijfer, S.; Strauss, D.; Sundby Hall, K.; Trama, A.; Unk, M.; van de Sande, M.A.J.; van der Graaf, W.T.A.; van Houdt, W.J.; Frebourg, T.; Ladenstein, R.; Casali, P.G.; Stacchiotti, S.

Bone sarcomas : ESMO–EURACAN–GENTURIS–ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up

In: Annals of Oncology Vol. 32 (2021) Nr. 12, pp. 1520 - 1536

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Bauer, Sebastian; Heinrich, Michael C.; George, Suzanne; Zalcberg, John R.; Serrano, César; Gelderblom, Hans; Jones, Robin L.; Attia, Steven; D'Amato, Gina; Chi, Ping; Reichardt, Peter; Meade, Julie; Su, Ying; Ruiz-Soto, Rodrigo; Blay, Jean-Yves; von Mehren, Margaret; Schöffski, Patrick

Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study

In: Clinical Cancer Research Vol. 27 (2021) Nr. 23, pp. 6333 - 6342

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Le Rhun, E.; Guckenberger, M.; Smits, M.; Dummer, R.; Bachelot, T.; Sahm, F.; Galldiks, N.; de Azambuja, E.; Berghoff, A.S.; Metellus, P.; Peters, S.; Hong, Y.-K.; Winkler, F.; Schadendorf, Dirk; van den Bent, M.; Seoane, J.; Stahel, R.; Minniti, G.; Wesseling, P.; Weller, M.; Preusser, M.

EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours

In: Annals of Oncology Vol. 32 (2021) Nr. 11, pp. 1332 - 1347

Online Full Text: dx.doi.org/ (Open Access)
Horak, Peter; Heining, Christoph; Kreutzfeldt, Simon; Hutter, Barbara; Mock, Andreas; Hüllein, Jennifer; Fröhlich, Martina; Uhrig, Sebastian; Jahn, Arne; Rump, Andreas; Gieldon, Laura; Möhrmann, Lino; Hanf, Dorothea; Teleanu, Veronica; Heilig, Christoph E.; Lipka, Daniel B.; Allgäuer, Michael; Ruhnke, Leo; Laßmann, Andreas; Endris, Volker; Neumann, Olaf; Penzel, Roland; Beck, Katja; Richter, Daniela; Winter, Ulrike; Wolf, Stephan; Pfütze, Katrin; Geörg, Christina; Meißburger, Bettina; Buchhalter, Ivo; Augustin, Marinela; Aulitzky, Walter E.; Hohenberger, Peter; Kroiss, Matthias; Schirmacher, Peter; Schlenk, Richard F.; Keilholz, Ulrich; Klauschen, Frederick; Folprecht, Gunnar; Bauer, Sebastian; Siveke, Jens; Brandts, Christian H.; Kindler, Thomas; Boerries, Melanie; Illert, Anna L.; von Bubnoff, Nikolas; Jost, Philipp J.; Spiekermann, Karsten; Bitzer, Michael; Schulze-Osthoff, Klaus; von Kalle, Christof; Klink, Barbara; Brors, Benedikt; Stenzinger, Albrecht; Schröck, Evelin; Hübschmann, Daniel; Weichert, Wilko; Glimm, Hanno; Fröhling, Stefan

Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers

In: Cancer Discovery Vol. 11 (2021) Nr. 11, pp. 2780 - 2795

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Syeda, Mahrukh M.; Wiggins, Jennifer M.; Corless, Broderick C; Long, Georgina V.; Flaherty, Keith T.; Schadendorf, Dirk; Nathan, Paul D.; Robert, Caroline; Ribas, Antoni; Davies, Michael A.; Grob, Jean Jacques; Gasal, Eduard; Squires, Matthew; Marker, Mahtab; Garrett, James; Brase, Jan C.; Polsky, David

Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib : A clinical validation study

In: The Lancet Oncology Vol. 22 (2021) Nr. 3, pp. 370 - 380

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Kohlhaas, Vivien; Blakemore, Stuart James; Al-Maarri, Mona; Nickel, Nadine; Pal, Martin; Roth, Andreas; Hövelmeyer, Nadine; Schäfer, Stephan C.; Knittel, Gero; Lohneis, Philipp; Nikolic, Milos; Wiederstein, Janica L.; Franitza, Marek; Georgomonolis, Theodoros; Reinart, Nina; Herling, Marco; Herling, Carmen; Hartmann, Elena M.; Rosenwald, Andreas; Klapper, Wolfram; Büttner, Reinhard; Moia, Riccardo; Rossi, Davide; Boldorini, Renzo; Gaidano, Gianluca; Frenzel, Lukas P.; Reinhardt, Christian; Brüning, Jens C.; Hallek, Michael; Krüger, Marcus; Peifer, Martin; Pallasch, Christian P.; Wunderlich, F. Thomas

Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1

In: Blood Vol. 137 (2021) Nr. 5, pp. 646 - 660

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Schuler, Martin

Corrigendum to “Inhibiting fibroblast growth factor receptors in cancer – The next generation”

In: Annals of Oncology Vol. 32 (2021) Nr. 1, pp. 126

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Klein, Sebastian; Quaas, Alexander; Quantius, Jennifer; Löser, Heike; Meinel, Jörn; Peifer, Martin; Wagner, Steffen; Gattenlöhner, Stefan; Wittekindt, Claus; von Knebel Doeberitz, Magnus; Prigge, Elena-Sophie; Langer, Christine; Noh, Ka-Won; Maltseva, Margaret; Reinhardt, Hans Christian; Büttner, Reinhard; Klussmann, Jens Peter; Wuerdemann, Nora

Deep Learning Predicts HPV Association in Oropharyngeal Squamous Cell Carcinomas and Identifies Patients with a Favorable Prognosis Using Regular H&E Stains

In: Clinical Cancer Research Vol. 27 (2021) Nr. 4, pp. 1131 - 1138

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Hope, Thomas A.; Eiber, Matthias; Armstrong, Wesley R.; Juarez, Roxanna; Murthy, Vishnu; Lawhn-Heath, Courtney; Behr, Spencer C.; Zhang, Li; Barbato, Francesco; Ceci, Francesco; Farolfi, Andrea; Schwarzenböck, Sarah M.; Unterrainer, Marcus; Zacho, Helle D.; Nguyen, Hao G.; Cooperberg, Matthew R.; Carroll, Peter R.; Reiter, Robert E.; Holden, Stuart; Herrmann, Ken; Zhu, Shaojun; Fendler, Wolfgang; Czernin, Johannes; Calais, Jeremie

Diagnostic Accuracy of ⁶⁸Ga-PSMA-11 PET for Pelvic Nodal Metastasis Detection Prior to Radical Prostatectomy and Pelvic Lymph Node Dissection : A Multicenter Prospective Phase 3 Imaging Trial

In: JAMA Oncology Vol. 7 (2021) Nr. 11, pp. 1635 - 1642

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Abel, Frederik; Giebel, Bernd; Frey, Ulrich H.

Agony of choice : How anesthetics affect the composition and function of extracellular vesicles

In: Advanced Drug Delivery Reviews Vol. 175 (2021) 113813

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Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : distant metastasis-free survival results from a double-blind, randomised, controlled, phase 3 trial

In: The Lancet Oncology Vol. 22 (2021) Nr. 5, pp. 643 - 654

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Chuang, Chen-Hua; Dorsch, Madeleine; Dujardin, Philip; Silas, Sukrit; Ueffing, Kristina; Hölken, Johanna M; Yang, Dian; Winslow, Monte M.; Grüner, Barbara M.

Altered mitochondria functionality defines a metastatic cell state in lung cancer and creates an exploitable vulnerability

In: Cancer Research Vol. 81 (2021) Nr. 3, pp. 567 - 579

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Littwitz-Salomon, Elisabeth; Moreira, Diana; Frost, Joe N.; Choi, Chloe; Liou, Kevin T.; Ahern, David K.; O’Shaughnessy, Simon; Wagner, Bernd; Biron, Christine A.; Drakesmith, Hal; Dittmer, Ulf; Finlay, David K.

Metabolic requirements of NK cells during the acute response against retroviral infection

In: Nature Communications Vol. 12 (2021) Nr. 1, 5376

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Quambusch, Lena; Depta, Laura; Landel, Ina; Lubeck, Melissa; Kirschner, Tonia; Nabert, Jonas; Uhlenbrock, Niklas; Weisner, Jörn; Kostka, Michael; Levy, Laura M.; Schultz-Fademrecht, Carsten; Glanemann, Franziska; Althoff, Kristina; Müller, Matthias P.; Siveke, Jens; Rauh, Daniel

Cellular model system to dissect the isoform-selectivity of Akt inhibitors

In: Nature Communications Vol. 12 (2021) Nr. 1, 5297

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Şahin, Uǧur; Türeci, Özlem; Manikhas, Georgiy Moiseevich; Lordick, Florian; Rusyn, Andrii; Vynnychenko, Ihor A.; Dudov, Asen; Bazin, Igor S.; Bondarenko, Igor; Melichar, Bohuslav; Dhaene, Karl F.L.; Wiechen, Kai; Huber, Claudia; Maurus, Daniel; Arozullah, A.; Park, J.W.; Schuler, Martin; Al-Batran, Salah Eddin

FAST : a randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric and gastro-oesophageal adenocarcinoma

In: Annals of Oncology Vol. 32 (2021) Nr. 5, pp. 609 - 619

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Herrmann, Ken; Kraus, Bernd Joachim; Hadaschik, Boris; Kunikowska, Jolanta; van Poppel, Hendrik; N'Dow, James; Sartor, Oliver; Oyen, Wim J. G.

Nuclear medicine theranostics comes of age

In: The Lancet Oncology Vol. 22 (2021) Nr. 11, pp. 1497 - 1498

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MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I

In: Nature Communications Vol. 12 (2021) Nr. 1, 5505

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Kolokotronis, Theodoros; Reis, Henning; Kroiss, Matthias

Multiple Hepatic and Pulmonary Tumors Combined with Bilateral Adrenal Masses in a Young Woman with von Hippel–Lindau Disease

In: Gastroenterology Vol. 161 (2021) Nr. 4, pp. e1 - e4

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Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas

In: Blood Vol. 137 (2021) Nr. 20, pp. 2785 - 2799

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Lutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer

In: The New England Journal of Medicine Vol. 385 (2021) pp. 1091 - 1103

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Chen, Jieliang; Li, Yaming; Lai, Fritz; Wang, Yang; Sutter, Kathrin; Dittmer, Ulf; Ye, Jianyu; Zai, Wenjing; Liu, Min; Shen, Fang; Wu, Min; Hu, Kongying; Li, Baocun; Lu, Mengji; Zhang, Xiaonan; Zhang, Jiming; Li, Jianhua; Chen, Qingfeng; Yuan, Zhenghong

Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ Signaling

In: Hepatology Vol. 73 (2021) Nr. 2, pp. 486 - 502

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Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion

In: Nature Genetics Vol. 53 (2021) Nr. 3, pp. 332 - 341

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Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas

In: Leukemia Vol. 35 (2021) pp. 2002 - 2016

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Gafita, Andrei; Calais, Jeremie; Grogan, Tristan R.; Hadaschik, Boris; Wang, Hui; Weber, Manuel; Sandhu, Shahneen; Kratochwil, Clemens; Esfandiari, Rouzbeh; Tauber, Robert; Zeldin, Anna; Rathke, Hendrik; Armstrong, Wesley R.; Robertson, Andrew; Thin, Pan; D'Alessandria, Calogero; Rettig, Matthew B.; Delpassand, Ebrahim S.; Haberkorn, Uwe; Elashoff, David; Herrmann, Ken; Czernin, Johannes; Hofman, Michael S.; Fendler, Wolfgang; Eiber, Matthias

Nomograms to predict outcomes after ¹⁷⁷Lu-PSMA therapy in men with metastatic castration-resistant prostate cancer : An international, multicentre, retrospective study

In: The Lancet Oncology Vol. 22 (2021) Nr. 8, pp. 1115 - 1125

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Bebber, Christina M.; Thomas, Emily S.; Stroh, Jenny; Chen, Zhiyi; Androulidaki, Ariadne; Schmitt, Anna; Höhne, Michaela N.; Stüker, Lukas; de Pádua Alves, Cleidson; Khonsari, Armin; Dammert, Marcel A.; Parmaksiz, Fatma; Tumbrink, Hannah L.; Beleggia, Filippo; Sos, Martin L.; Riemer, Jan; George, Julie; Brodesser, Susanne; Thomas, Roman K.; Reinhardt, Christian; von Karstedt, Silvia

Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 2048

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Weniger, Marc; Küppers, Ralf

Molecular biology of Hodgkin lymphoma

In: Leukemia Vol. 35 (2021) Nr. 4, pp. 968 - 981

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Sobecki, Michal; Krzywinska, Ewelina; Nagarajan, Shunmugam; Audigé, Annette; Huỳnh, Khanh; Zacharjasz, Julian; Debbache, Julien; Kerdiles, Yann; Gotthardt, Dagmar; Takeda, Norihiko; Fandrey, Joachim; Sommer, Lukas; Sexl, Veronika; Stockmann, Christian

NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence

In: Nature Communications Vol. 12 (2021) Nr. 1, 4700

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Wey, Karolin; Schirrmann, Ronja; Diesing, Detlef; Lang, Stephan; Brandau, Sven; Hansen, Stefan; Epple, Matthias

Coating of cochlear implant electrodes with bioactive DNA-loaded calcium phosphate nanoparticles for the local transfection of stimulatory proteins

In: Biomaterials Vol. 276 (2021)

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Zhang, Xiang; Schuhmachers, Patrick; Mourão, André; Giansanti, Piero; Murer, Anita; Thumann, Sybille; Kuklik-Roos, Cornelia; Beer, Sophie; Hauck, Stefanie M; Hammerschmidt, Wolfgang; Küppers, Ralf; Kuster, Bernhard; Raab, Monika; Strebhardt, Klaus; Sattler, Michael; Münz, Christian; Kempkes, Bettina

PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice

In: EMBO Reports (2021) e53007

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Kienle, Korbinian; Glaser, Katharina M.; Eickhoff, Sarah; Mihlan, Michael; Knöpper, Konrad; Reátegui, Eduardo; Epple, Maximilian W.; Gunzer, Matthias; Baumeister, Ralf; Tarrant, Teresa K.; Germain, Ronald N.; Irimia, Daniel; Kastenmüller, Wolfgang; Lämmermann, Tim

Neutrophils self-limit swarming to contain bacterial growth in vivo

In: Science Vol. 372 (2021) Nr. 6548,

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Nguyen, Tan-Trieu; Ramsay, Lee Ann; Ahanfeshar-Adams, Mozhdeh; Lajoie, Mathieu; Schadendorf, Dirk; Alain, Tommy; Watson, Ian R.

Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment

In: Clinical Cancer Research Vol. 27 (2021) Nr. 12, pp. 3432 - 3442

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Nuclear receptor coactivator NCOA3 regulates UV radiation⇓induced DNA damage and melanoma susceptibility

In: Cancer Research Vol. 81 (2021) Nr. 11, pp. 2956 - 2969

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GPR15 facilitates recruitment of regulatory T cells to promote colorectal cancer

In: Cancer Research Vol. 81 (2021) Nr. 11, pp. 2970 - 2982

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Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects

In: Molecular Psychiatry Vol. 26 (2021) Nr. 12, pp. 7403 - 7416

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Iliakis, George E.

New players in the regulation of DNA-PK activity : Survivin joins the crowd

In: Cancer Research Vol. 81 (2021) Nr. 9, pp. 2270 - 2271

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Phase I assessment of safety and therapeutic activity of BAY1436032 in patients with IDH1-mutant solid tumors

In: Clinical Cancer Research Vol. 27 (2021) Nr. 10, pp. 2723 - 2733

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PI3KC2β inactivation stabilizes VE‐cadherin junctions and preserves vascular integrity

In: EMBO Reports (2021) pp. e51299

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Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid

In: Immunity Vol. 54 (2021) Nr. 1, pp. 164

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Veach, Darren R.; Storey, Claire M.; Lückerath, Katharina; Braun, Katharina; von Bodman, Christian; Lamminmäki, Urpo; Kalidindi, Teja; Strand, Sven-Erik; Strand, Joanna; Altai, Mohamed; Damoiseaux, Robert; Zanzonico, Pat; Benabdallah, Nadia; Pankov, Dmitry; Scher, Howard I.; Scardino, Peter; Larson, Steven M.; Lilja, Hans; McDevitt, Michael R.; Thorek, Daniel L.J.; Ulmert, David

PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates

In: Clinical Cancer Research Vol. 27 (2021) Nr. 7, pp. 2050 - 2060

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Peña-Llopis, Samuel

Leadership challenges defused

In: Science Vol. 371 (2021) Nr. 6533, pp. 1070

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Nab-paclitaxel plus gemcitabine versus nab-paclitaxel plus gemcitabine followed by FOLFIRINOX induction chemotherapy in locally advanced pancreatic cancer (NEOLAP-AIO-PAK-0113) : a multicentre, randomised, phase 2 trial

In: The Lancet Gastroenterology & Hepatology Vol. 6 (2021) Nr. 2, pp. 128 - 138

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Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis

In: Cell Reports Vol. 37 (2021) Nr. 8, 110056

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Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM

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Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy

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Post-transplantation cyclophosphamide GvHD prophylaxis after hematopoietic stem cell transplantation from 9/10 or 10/10 HLA-matched unrelated donors for acute leukemia

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Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies

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Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19 : Current evidence and potential mechanisms

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Role of Tumor-Infiltrating B Cells in Clinical Outcome of Patients with Melanoma Treated With Dabrafenib Plus Trametinib

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Pralsetinib for patients with advanced or metastatic RET-altered thyroid cancer (ARROW) : a multi-cohort, open-label, registrational, phase 1/2 study

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Sotorasib for Lung Cancers with KRAS p.G12C Mutation

In: The New England Journal of Medicine Vol. 384 (2021) Nr. 25, pp. 2371 - 2381

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Resistance to avapritinib in pdgfra-driven gist is caused by secondary mutations in the pdgfra kinase domain

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SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19

In: Nature Communications Vol. 12 (2021) Nr. 1, pp. 1813

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The West German heart and vascular center at university medicine Essen

In: European Heart Journal Vol. 42 (2021) Nr. 10, pp. 963 - 964

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UMI or not UMI, that is the question for scRNA-seq zero-inflation

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Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache : A multicentre, double-blind, randomised controlled trial

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Scaled preparation of extracellular vesicles from conditioned media

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Soft tissue and visceral sarcomas : ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up☆

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Sugar-modified B-cell receptors in DLBCL

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TRIP6 functions in brain ciliogenesis

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Tumor-associated hematopoietic stem and progenitor cells positively linked to glioblastoma progression

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2020

Küppers, Ralf; Schadendorf, Dirk; Stein, Lincoln D.; PCAWG Consortium

A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

In: Nature Communications Vol. 11 (2020) 728

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Küppers, Ralf; Schadendorf, Dirk; Feuerbach, Lars; PCAWG Consortium

Genomic footprints of activated telomere maintenance mechanisms in cancer

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Küppers, Ralf; Schadendorf, Dirk; Bristow, Robert G.; Boutros, Paul C.; PCAWG Consortium

Divergent mutational processes distinguish hypoxic and normoxic tumours

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Küppers, Ralf; Schadendorf, Dirk

Pathway and network analysis of more than 2500 whole cancer genomes

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Anemia increases long-term mortality in patients undergoing conventional coronary angiography – the ECAT registry
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In: European Heart Journal Vol. 41 (2020) Nr. Supplement_2, pp. 1508

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Combined burden and functional impact tests for cancer driver discovery using DriverPower

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A clinical perspective on the 2019 ESC/EAS guidelines for the management of dyslipidaemias: PCSK-9 inhibitors for all?

In: European Heart Journal Vol. 41 (2020) Nr. 24, pp. 2331

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High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

In: Nature Communications Vol. 11 (2020) 736

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Küppers, Ralf; Schadendorf, Dirk; Cmero, Marek; Macintyre, Geoff; PCAWG Consortium

Inferring structural variant cancer cell fraction

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Integrative pathway enrichment analysis of multivariate omics data

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Investigating PSMA-Targeted Radioligand Therapy Efficacy as a Function of Cellular PSMA Levels and Intratumoral PSMA Heterogeneity

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Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 6232

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Cemiplimab in locally advanced cutaneous squamous cell carcinoma : results from an open-label, phase 2, single-arm trial

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Integrative Analysis of Pleomorphic Dermal Sarcomas Reveals Fibroblastic Differentiation and Susceptibility to Immunotherapy

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Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK Pathway

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Co-option of Neutrophil Fates by Tissue Environments

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Integrated molecular drivers coordinate biological and clinical states in melanoma

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Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes

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Radiotheranostics : A roadmap for future development

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External validation of models for KIR2DS1/KIR3DL1-informed selection of hematopoietic cell donors fails

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Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility

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Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

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Cardiac fibroblast activation detected by positron emission tomography/computed tomography as a possible sign of cardiotoxicity

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Combined PD-1, BRAF and MEK inhibition in advanced BRAF-mutant melanoma : safety run-in and biomarker cohorts of COMBI-i

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Author Correction: Tertiary lymphoid structures improve immunotherapy and survival in melanoma

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3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors

In: Nature Communications Vol. 10 (2019) pp. 4529

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Peters, Triinu; Hebebrand, Johannes; Hinney, Anke; Scherag, Andre; Depienne, C.

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms Across Eight Psychiatric Disorders

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Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma

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Reply [Letter to the Editor: Characterization of CD169+ Macrophages in Liver Regeneration: Tissue Distribution and Fate?]

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Axon-like protrusions promote small cell lung cancer migration and metastasis

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Five-year outcomes with dabrafenib plus trametinib in metastatic melanoma

In: The New England Journal of Medicine Vol. 381 (2019) Nr. 7, pp. 626 - 636

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Liu, David; Schilling, Bastian; Liu, Derek; Sucker, Antje; Livingstone, Elisabeth; Jerby-Amon, Livnat; Zimmer, Lisa; Gutzmer, Ralf; Satzger, Imke; Loquai, Carmen; Grabbe, Stephan; Vokes, Natalie; Margolis, Claire A.; Conway, Jake; He, Meng Xiao; Elmarakeby, Haitham; Dietlein, Felix; Miao, Diana; Tracy, Adam; Gogas, Helen; Goldinger, Simone M.; Utikal, Jochen; Blank, Christian U.; Rauschenberg, Ricarda; Bubnoff, Dagmar von; Krackhardt, Angela; Weide, Benjamin; Haferkamp, Sebastian; Kiecker, Felix; Izar, Ben; Garraway, Levi; Regev, Aviv; Flaherty, Keith; Paschen, Annette; Allen, Eliezer M. van; Schadendorf, Dirk

Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma

In: Nature Medicine Vol. 25 (2019) Nr. 12, pp. 1916 - 1927

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Quambusch, Lena; Landel, Ina; Depta, Laura; Weisner, Jörn; Uhlenbrock, Niklas; Müller, Matthias P.; Glanemann, Franziska; Althoff, Kristina; Siveke, Jens; Rauh, Daniel

Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity

In: Angewandte Chemie International Edition Vol. 58 (2019) Nr. 52, pp. 18823 - 18829

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Current gaps in sepsis immunology: new opportunities for translational research

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EAU–ESMO consensus statements on the management of advanced and variant bladder cancer - an international collaborative multi-stakeholder effort : under the auspices of the EAU and ESMO Guidelines Committees

In: Annals of Oncology Vol. 30 (2019) Nr. 11, pp. 1697 - 1727

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Human gastric cancer modelling using organoids

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Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

In: Cancer Cell Vol. 36 (2019) Nr. 3, pp. 319 - 336.e7

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Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

In: The New England Journal of Medicine Vol. 381 (2019) Nr. 16, pp. 1535 - 1546

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MMP2/MMP9-mediated CD100 shedding is crucial for inducing intrahepatic anti-HBV CD8 T cell responses and HBV clearance

In: Journal of Hepatology Vol. 71 (2019) Nr. 4, pp. 685 - 698

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Prostate-specific membrane antigen ligand positron emission tomography in men with nonmetastatic castration-resistant prostate cancer

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A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus : the MONO study

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Phung, Bengt; Cieśla, Maciej; Sanna, Adriana; Guzzi, Nicola; Beneventi, Giulia; Cao Thi Ngoc, Phuong; Lauss, Martin; Cabrita, Rita; Cordero, Eugenia; Bosch, Ana; Rosengren, Frida; Häkkinen, Jari; Griewank, Klaus; Paschen, Annette; Harbst, Katja; Olsson, Håkan; Ingvar, Christian; Carneiro, Ana; Tsao, Hensin; Schadendorf, Dirk; Pietras, Kristian; Bellodi, Cristian; Jönsson, Göran

The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma

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Stepanova, Tatyana; Haefeli, Walter-Emil; Dittmer, Ulf; Ciesek, Sandra; Bremer, Birgit; Dandri, Maura; Burhenne, Jürgen; Voronkova, Natalia; Wedemeyer, Heiner; Alexandrov, Alexander; Urban, Stephan; Allweiss, Lena; Bogomolov, Pavel O.; Schöneweis, Katrin; Chulanov, Vladimir

Final results of a multicenter, open-label phase 2 clinical trial (MYR203) to assess safety and efficacy of myrcludex B in cwith PEG-interferon Alpha 2a in patients with chronic HBV/HDV co-infection

In: Journal of Hepatology Vol. 70 (2019) Nr. 1 Suppl., pp. e81

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Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer

In: Immunity Vol. 50 (2019) Nr. 1, pp. 166 - 180.e7

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Dittmer, Ulf; Sutter, Kathrin; Kassiotis, George; Zelinskyy, Gennadiy; Bánki, Zoltán; Stoiber, Heribert; Santiago, Mario L.; Hasenkrug, Kim J.

Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity

In: FEMS Microbiology Reviews Vol. 43 (2019) Nr. 5, pp. 435 - 456

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Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

In: Nature Vol. 569 (2019) Nr. 7755, pp. 236 - 240

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Watson, Hunna J.; Hinney, Anke; Giuranna, Johanna; Hebebrand, Johannes

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

In: Nature Genetics Vol. 51 (2019) Nr. 8, pp. 1207 - 1214

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Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1459

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Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2312

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Schadendorf, Dirk; Livingstone, Elisabeth; Zimmer, Lisa

Treatment in metastatic melanoma : Time to re-think

In: Annals of Oncology Vol. 30 (2019) Nr. 4, pp. 501 - 503

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Weisner, Jörn; Landel, Ina; Reintjes, Christoph; Uhlenbrock, Niklas; Trajkovic-Arsic, Marija; Dienstbier, Niklas; Hardick, Julia; Ladigan, Swetlana; Lindemann, Marius; Smith, Steven; Quambusch, Lena; Scheinpflug, Rebekka; Depta, Laura; Gontla, Rajesh; Unger, Anke; Müller, Heiko; Baumann, Matthias; Schultz-Fademrecht, Carsten; Gunther, Georgia; Maghnouj, Abdelouahid; Müller, Matthias P.; Pohl, Michael; Teschendorf, Christian; Wolters, Heiner; Viebahn, Richard; Tannapfel, Andrea; Uhl, Waldemar; Hengstler, Jan G.; Hahn, Stephan A.; Siveke, Jens; Rauh, Daniel

Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer

In: Cancer Research Vol. 79 (2019) Nr. 9, pp. 2367 - 2378

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Machine learning-based predictors for immune checkpoint inhibitor therapy of non-small-cell lung cancer

In: Annals of Oncology Vol. 30 (2019) Nr. 4, pp. 655 - 657

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Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins

In: Cell Reports Vol. 27 (2019) Nr. 7, pp. 2092 - 2104.e10

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Hüllein, Jennifer; Słabicki, Mikołaj; Rosolowski, Maciej; Jethwa, Alexander; Habringer, Stefan; Tomska, Katarzyna; Kurilov, Roma; Lu, Junyan; Scheinost, Sebastian; Wagener, Rabea; Huang, Zhiqin; Lukas, Marina; Yavorska, Olena; Helfrich, Hanne; Scholtysik, René; Bonneau, Kyle; Tedesco, Donato; Küppers, Ralf; Klapper, Wolfram; Pott, Christiane; Stilgenbauer, Stephan; Burkhardt, Birgit; Löffler, Markus; Trümper, Lorenz H.; Hummel, Michael; Brors, Benedikt; Zapatka, Marc; Siebert, Reiner; Kreuz, Markus; Keller, Ulrich; Huber, Wolfgang; Zenz, Thorsten

MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma

In: Cancer Research Vol. 79 (2019) Nr. 12, pp. 3125 - 3138

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Fendler, Wolfgang P.; Calais, Jeremie; Eiber, Matthias; Flavell, Robert R.; Mishoe, Ashley; Feng, Felix Y.; Nguyen, Hao G.; Reiter, Robert E.; Rettig, Matthew B.; Okamoto, Shozo; Emmett, Louise; Zacho, Helle D.; Ilhan, Harun; Wetter, Axel; Rischpler, Christoph; Schoder, Heiko; Burger, Irene A.; Gartmann, Jeannine; Smith, Raven; Small, Eric J.; Slavik, Roger; Carroll, Peter R.; Herrmann, Ken; Czernin, Johannes; Hope, Thomas A.

Assessment of ⁶⁸Ga-PSMA-11 PET Accuracy in Localizing Recurrent Prostate Cancer : A Prospective Single-Arm Clinical Trial

In: JAMA Oncology Vol. 5 (2019) Nr. 6, pp. 856 - 863

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Emmons, Michael F.; Faião-Flores, Fernanda; Sharma, Ritin; Thapa, Ram; Messina, Jane L.; Becker, Jürgen; Schadendorf, Dirk; Seto, Edward; Sondak, Vernon K.; Koomen, John M.; Chen, Yian A.; Lau, Eric K.; Wan, Lixin; Licht, Jonathan D.; Smalley, Keiran S. M.

HDAC8 regulates a stress response pathway in melanoma to mediate escape from BRAF inhibitor therapy

In: Cancer Research Vol. 79 (2019) Nr. 11, pp. 2947 - 2961

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Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4) : A randomised, phase 2/3 trial

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Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation

In: Nature Medicine Vol. 25 (2019) Nr. 4, pp. 603 - 611

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Schuler, Martin; Cho, Byoung Chul; Sayehli, Cyrus Michael; Navarro, Alejandro; Soo, Ross A.; Richly, Heike; Cassier, Philippe Alexandre; Tai, David; Penel, Nicolas; Nogova, Lucia; Park, Se Hoon; Schostak, Martin; Gajate, Pablo; Cathomas, Richard; Rajagopalan, Prabhu; Grevel, Joachim; Bender, Sebastian; Boix, Oliver; Nogai, Hendrik; Ocker, Matthias; Ellinghaus, Peter; Joerger, Markus

Rogaratinib in patients with advanced cancers selected by FGFR mRNA expression : a phase 1 dose-escalation and dose-expansion study

In: The Lancet Oncology Vol. 20 (2019) Nr. 10, pp. 1454 - 1466

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Schadendorf, Dirk; Hauschild, Axel; Santinami, Mario; Atkinson, Victoria; Mandalà, Mario; Chiarion-Sileni, Vanna; Larkin, James; Nyakas, Marta; Dutriaux, Caroline; Haydon, Andrew; Robert, Caroline; Mortier, Laurent; Lesimple, Thierry; Plummer, Ruth; Schachter, Jacob; Dasgupta, Kohinoor; Manson, Stephanie; Koruth, Roy; Mookerjee, Bijoyesh; Kefford, Richard; Dummer, Reinhard; Kirkwood, John M.; Long, Georgina V.

Patient-reported outcomes in patients with resected, high-risk melanoma with BRAFV600E or BRAFV600K mutations treated with adjuvant dabrafenib plus trametinib (COMBI-AD) : a randomised, placebo-controlled, phase 3 trial

In: The Lancet Oncology Vol. 20 (2019) Nr. 5, pp. 701 - 710

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Juric, Dejan; Janku, Filip; Rodón, Jordi; Burris, Howard A.; Mayer, Ingrid A.; Schuler, Martin; Seggewiss-Bernhardt, Ruth; Gil-Martin, Marta; Middleton, Mark R.; Baselga, José; Bootle, Douglas; Demanse, David; Blumenstein, Lars; Schumacher, Karl; Huang, Alan; Quadt, Cornelia; Rugo, Hope S.

Alpelisib Plus Fulvestrant in PIK3CA -Altered and PIK3CA -Wild-Type Estrogen Receptor-Positive Advanced Breast Cancer : A Phase 1b Clinical Trial

In: JAMA Oncology Vol. 5 (2019) Nr. 2, pp. e184475

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Defective homologous recombination DNA repair as therapeutic target in advanced chordoma

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1635

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Fleming, Viktor; Hu, Xiaoying; Weller, Céline; Weber, Rebekka; Groth, Christopher; Riester, Zeno; Hüser, Laura; Sun, Qian; Nagibin, Vasyl; Kirschning, Carsten Jürgen; Bronte, Vincenzo; Utikal, Jochen; Altevogt, Peter; Umansky, Viktor

Melanoma extracellular vesicles generate immunosuppressive myeloid cells by upregulating PD-L1 via TLR4 signaling

In: Cancer Research Vol. 79 (2019) Nr. 18, pp. 4715 - 4728

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Publisher Correction: Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 299

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Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8⁺ T Cells and Evolve at the Population Level

In: Gastroenterology Vol. 156 (2019) Nr. 6, pp. 1820 - 1833

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UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

In: Cell Vol. 176 (2019) Nr. 3, pp. 505 - 519.e22

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Microglial cell loss after ischemic stroke favors brain neutrophil accumulation

In: Acta Neuropathologica Vol. 137 (2019) Nr. 2, pp. 321 - 341

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Tap, William D.; Gelderblom, Hans; Palmerini, Emanuela; Desai, Jayesh; Bauer, Sebastian; Blay, Jean-Yves; Alcindor, Thierry; Ganjoo, Kristen; Martín-Broto, Javier; Ryan, Christopher W.; Thomas, David M.; Peterfy, Charles; Healey, John H.; Sande, Michiel van de; Gelhorn, Heather L.; Shuster, Dale E.; Wang, Qiang; Yver, Antoine; Hsu, Henry H.; Lin, Paul S.; Tong-Starksen, Sandra; Stacchiotti, Silvia; Wagner, Andrew J.

Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN) : a randomised phase 3 trial

In: Lancet Vol. 394 (2019) Nr. 10197, pp. 478 - 487

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Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF melanoma (PACMEL) : a multicentre, open-label, randomised, controlled phase II trial

In: Annals of Oncology Vol. 30 (2019) Nr. 2, pp. 317 - 324

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Schadendorf, Dirk; Melanoma GWAS Consortium

Publisher Correction : Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 299

Online Full Text: dx.doi.org/ (Open Access)
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Publisher Correction: Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response

In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2768

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The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban

In: EMBO Reports Vol. 20 (2019) Nr. 3, pp. e46449

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Totzeck, Matthias; Mahabadi, Amir Abbas; Schlosser, Thomas Wilfried; Rassaf, Tienush

Weightlifting unmasks high-risk coronary anomaly

In: European Heart Journal Vol. 40 (2019) Nr. 1, pp. 72

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Krawczyk, Adalbert; Bazinet, Michel; Pantea, Victor; Cotler, Scott; Dahari, Harel; Shekhtman, Louis; Jimbei, Pavlina; Cojuhari, Lilia; Cebotarescu, Valentin; Uprichard, Susan; Vaillant, Andrew

Understanding HDV and HBsAg kinetics during nucleic acid polymer REP 2139 mono-therapy in HBeAg-negative chronic HBV/HDV co-infected patients via mathematical modeling

In: Journal of Hepatology Vol. 70 (2019) Nr. 1 Suppl., pp. e463

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Survival Outcomes in Patients with Previously Untreated BRAF Wild-Type Advanced Melanoma Treated with Nivolumab Therapy : Three-Year Follow-up of a Randomized Phase 3 Trial

In: JAMA Oncology Vol. 5 (2019) Nr. 2, pp. 187 - 194

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Krawczyk, Adalbert; et.al.

Establishment of High Rates of Functional Control and Reversal of Fibrosis Following Treatment of Hbeag Negative Chronic HBV Infection with REP 2139-Mg / REP 2165-Mg, Tenofovir Disoproxil Fumarate and Pegylated Interferon Alpha-2a

In: Hepatology Vol. 68 (2018) Nr. S1, pp. 234A - 235A

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Chen, Li Tzon; Macarulla, Teresa M.; Blanc, Jean Frédéric; Mirakhur, Beloo; Jong, Floris A. de; Belanger, Bruce; Bekaii-Saab, Tanios; Siveke, Jens

Impact of dose reduction or dose delay on the efficacy of liposomal irinotecan (nal-IRI)+5-fluorouracil/leucovorin (5-FU/LV) : Survival analysis from NAPOLI-1

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii250 - viii251

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Bayo, Juan; Tran, Tram Anh; Wang, Lei; Peña-Llopis, Samuel; Das, Amit K.; Martinez, Elisabeth D.

Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks

In: Cell Reports Vol. 25 (2018) Nr. 4, pp. 1040 - 1050.e5

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Hodi, Frank S.; Chiarion-Sileni, Vanna; Gonzalez, René C.; Grob, Jean J.; Rutkowski, Piotr; Cowey, Charles L.; Lao, Christopher D.; Schadendorf, Dirk; Wagstaff, John; Dummer, Reinhard G.; Ferrucci, Pier F.; Smylie, Michael; Hill, A. G.; Hogg, David; Márquez-Rodas, Iván; Jiang, Joel; Rizzo, Jasmine I.; Larkin, James M. G.; Wolchok, J.

Overall survival at 4 years of follow-up in a phase III trial of nivolumab plus ipilimumab combination therapy in advanced melanoma (CheckMate 067)

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii735

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Grünwald, Viktor; Schuler, Martin H.; Schöffski, Patrick; Kopp, Hans-Georg; Bauer, Sebastian; Kasper, Bernd; Lindner, Lars H.; Chemnitz, Jens M.; Crysandt, Martina; Stein, Alexander; Steffen, B.; Richter, Stephan; Kneba, Michael; Egerer, Gerlinde; Zimmermann, S.; Karch, Annika; Kunitz, Annegret

Health-related quality of life (HR-QoL) in elderly soft tissue sarcoma (STS) patients from the randomized phase II EPAZ study comparing pazopanib (PAZ) and doxorubicin (DOX) in first line

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii577

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George, Suzanne; Bauer, Sebastian; Jones, Robin L.; Serrano, Christina S.; Mehren, Margaret M. von; Kang, Y.-K.; Schöffski, Patrick; Cassier, Philippe A.; Eskens, Ferry A.; Mir, Olivier; Tap, William D.; Chawla, Sant P.; Rutkowski, Piotr; Shi, H.; Schmidt-Kittler, Oleg; Mar, B.; Heinrich, Michael

Correlation of ctDNA and response in patients (pts) with PDGFRα D842 GIST treated with avapritinib

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii584

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Adverse events (AEs) over time in patients (pts) treated with adjuvant dabrafenib plus trametinib (D + T) or placebo (Pbo) in the COMBI-AD trial

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii446

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Adjuvant vemurafenib in resected, BRAF mutation-positive melanoma (BRIM8) : a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial

In: The Lancet Oncology Vol. 19 (2018) Nr. 4, pp. 510 - 520

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Estimate of long-term relapse-free survival (RFS) and analysis of baseline factors associated with RFS in the COMBI-AD trial

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii445

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Corrigendum: Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells

In: EMBO Reports Vol. 19 (2018) Nr. 12, pp. e47190

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Díaz-Carballo, David; Saka, Sahitya; Klein, Jacqueline; Rennkamp, Tobias; Acikelli, Ali H.; Malak, Sascha; Jastrow, Holger; Wennemuth, Gunther; Tempfer, Clemens; Schmitz, Inge; Tannapfel, Andrea; Strumberg, Dirk

A distinct oncogenerative multinucleated cancer cell serves as a source of stemness and tumor heterogeneity

In: Cancer Research Vol. 78 (2018) Nr. 9, pp. 2318 - 2331

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Langer, Samantha K; Cull, Alyssa; Wossidlo, Natalie; Klump, Hannes; Horn, Peter; Heinrichs, Stefan;

Distinct Gene Expression Patterns Drive Proliferation of Dominant-Negative RUNX1 Immortalized HSPCs
60th ASH Annual Meeting; December 1-4, 2018; San Diego, USA,

In: Blood Vol. 132 (2018) Nr. Supplement 1, pp. 1795 - 1795

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Extrahepatic Comorbidities Do Not Alter the Safety and Efficacy of Radioembolization of NAFLD-Associated HCC

In: Hepatology Vol. 68 (2018) Nr. Suppl. 1, pp. 852A - 853A
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Consensus on molecular imaging and theranostics in prostate cancer

In: The Lancet Oncology Vol. 19 (2018) Nr. 12, pp. e696 - e708

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Lee, K.; Bodoky, Gyorgy; Blanc, Jean Frédéric; Siveke, Jens; Macarulla Mercade, T.; Wang-Gillam, Andrew; Chen, L.; Mirakhur, Beloo; Chen, Jie; Jong, Floris A. de

Decreased appetite (DA) at baseline impacts prognosis in the NAPOLI-1 phase 3 study in metastatic pancreatic ductal adenocarcinoma (mPDAC)

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 5, pp. v42 - v43

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Grob, Jean Jacques; Garbe, Claus; Ascierto, Paolo; Larkin, James; Dummer, Reinhard; Schadendorf, Dirk

Adjuvant melanoma therapy with new drugs : Should physicians continue to focus on metastatic disease or use it earlier in primary melanoma?

In: The Lancet Oncology Vol. 19 (2018) Nr. 12, pp. e720 - e725

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Author Correction : The landscape of genomic alterations across childhood cancers

In: Nature Vol. 559 (2018) Nr. 7714, pp. E10

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Kugel, Curtis H.; Douglass, Stephen M.; Webster, Marie R.; Kaur, Amanpreet; Liu, Qin; Yin, Xiangfan; Weiss, Sarah A.; Darvishian, Farbod; Al-Rohil, Rami N.; Ndoye, Abibatou; Behera, Reeti; Alicea, Gretchen M.; Ecker, Brett L.; Fane, Mitchell; Allegrezza, Michael J.; Svoronos, Nikolaos; Kumar, Vinit; Wang, Daniel Y.; Somasundaram, Rajasekharan; Hu-Lieskovan, Siwen; Ozgun, Alpaslan; Herlyn, Meenhard; Conejo-Garcia, Jose R.; Gabrilovich, Dmitry; Stone, Erica L.; Nowicki, Theodore S.; Sosman, Jeffrey; Rai, Rajat; Carlino, Matteo S.; Long, Georgina V.; Marais, Richard; Ribas, Antoni; Eroglu, Zeynep; Davies, Michael A.; Schilling, Bastian; Schadendorf, Dirk; Xu, Wei; Amaravadi, Ravi K.; Menzies, Alexander M.; McQuade, Jennifer L.; Johnson, Douglas B.; Osman, Iman; Weeraratna, Ashani T.

Age correlates with response to anti-PD1, reflecting age-related differences in intratumoral effector and regulatory T-Cell populations

In: Clinical Cancer Research Vol. 24 (2018) Nr. 21, pp. 5347 - 5356

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Casali, P.G.; Bielack, S.; Abecassis, N.; Aro, H.T.; Bauer, Sebastian; Biagini, R.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Brennan, B.; Brodowicz, T.; Broto, J.M.; Brugières, L.; Buonadonna, A.; De Álava, E.; Dei Tos, A.P.; Del Muro, X.G.; Dileo, P.; Dhooge, C.; Eriksson, M.; Fagioli, F.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Ferrari, S.; Frezza, A.M.; Gaspar, N.; Gasperoni, S.; Gelderblom, H.; Gil, T.; Grignani, G.; Gronchi, A.; Haas, R.L.; Hassan, B.; Hecker-Nolting, S.; Hohenberger, P.; Issels, R.; Joensuu, H.; Jones, R.L.; Judson, I.; Jutte, P.; Kaal, S.; Kager, L.; Kasper, B.; Kopeckova, K.; Krákorová, D.A.; Ladenstein, R.; Le Cesne, A.; Lugowska, I.; Merimsky, O.; Montemurro, M.; Morland, B.; Pantaleo, M.A.; Piana, R.; Picci, P.; Piperno-Neumann, S.; Pousa, A.L.; Reichardt, P.; Robinson, M.H.; Rutkowski, P.; Safwat, A.A.; Schöffski, P.; Sleijfer, S.; Stacchiotti, S.; Strauss, S.J.; Sundby Hall, K.; Unk, M.; Van Coevorden, F.; Van Der Graaf, W.T.A.; Whelan, J.; Wardelmann, E.; Zaikova, O.; Blay, J.Y.

Bone sarcomas : ESMO-PaedCan-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 4, pp. iv79 - iv95

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Horst, Andrea Kristina; Wegscheid, Claudia; Schaefers, Christoph; Schiller, Birgit; Neumann, Katrin; Lunemann, Sebastian; Langeneckert, Annika E; Oldhafer, Karl J; Weiler-Normann, Christina; Lang, Karl S.; Singer, Bernhard B.; Altfeld, Marcus; Diehl, Linda; Tiegs, Gisa

Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice

In: Hepatology Vol. 68 (2018) Nr. 1, pp. 200 - 214

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Sauter, Reinhard J.; Sauter, Manuela; Reis, Edimara S.; Emschermann, Frederic N.; Nording, Henry; Ebenhöch, Sonja; Kraft, Peter; Münzer, Patrick; Mauler, Maximilian; Rheinlaender, Johannes; Madlung, Johannes; Edlich, Frank; Schäffer, Tilman E.; Meuth, Sven G.; Duerschmied, Daniel; Geisler, Tobias; Borst, Oliver; Gawaz, Meinrad; Kleinschnitz, Christoph; Lambris, John D.; Langer, Harald F.

Functional relevance of the anaphylatoxin receptor C3aR for platelet function and arterial thrombus formation marks an intersection point between innate immunity and thrombosis

In: Circulation Vol. 138 (2018) Nr. 16, pp. 1720 - 1735

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Fan, Kaiji; Ritter, Cathrin; Nghiem, Paul; Blom, Astrid; Verhaegen, Monique E.; Dlugosz, Andrzej; Ødum, Niels; Woetmann, Anders; Tothill, Richard W.; Hicks, Rodney J.; Sand, Michael; Schrama, David; Schadendorf, Dirk; Ugurel, Selma; Becker, Jürgen C.

Circulating cell-free miR-375 as surrogate marker of tumor burden in Merkel cell carcinoma

In: Clinical Cancer Research Vol. 24 (2018) Nr. 23, pp. 5873 - 5882

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Shukla, Sachet A.; Bachireddy, Pavan; Schilling, Bastian; Galonska, Christina; Zhan, Qian; Bango, Clyde; Langer, Rupert; Lee, Patrick C.; Gusenleitner, Daniel; Keskin, Derin B.; Babadi, Mehrtash; Mohammad, Arman; Gnirke, Andreas; Clement, Kendell; Cartun, Zachary J.; Van Allen, Eliezer M.; Miao, Diana; Huang, Ying; Snyder, Alexandra; Merghoub, Taha; Wolchok, Jedd D.; Garraway, Levi A.; Meissner, Alexander; Weber, Jeffrey S.; Hacohen, Nir; Neuberg, Donna; Potts, Patrick R.; Murphy, George F.; Lian, Christine G.; Schadendorf, Dirk; Hodi, F. Stephen; Wu, Catherine J.

Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade

In: Cell Vol. 173 (2018) Nr. 3, pp. 624 - 633.e8

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Macarulla Mercade, Teresa; Bodoky, Gyorgy; Siveke, Jens; Lee, Kyung-hun; Chen, J.; Mirakhur, Beloo; Dean, Andrew; Chen, Li-Tzong; Jong, Floris A. de

NAPOLI-1 phase III trial outcomes by prior surgery, and disease stage, in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC)

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii249 - viii250

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Jockenhöfer, Finja; Schimming, Tobias T.; Schaller, Jörg; Moege, Jürgen; Livingstone, Elisabeth; Salva, Katrin A.; Zimmer, Lisa; Schadendorf, Dirk; Rösch, Alexander

Sebaceous tumours: more than skin deep

In: Gut Vol. 67 (2018) Nr. 11, pp. 2045 - 2053

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Lecouvet, Frédéric E.; Oprea-Lager, Daniela E.; Liu, Yan; Ost, Piet; Bidaut, Luc; Collette, Laurence; Deroose, Christophe M.; Goffin, Karolien; Herrmann, Ken; Hoekstra, Otto S.; Kramer, Gem; Lievens, Yolande; Lopci, Egesta; Pasquier, David; Petersen, Lars J.; Talbot, Jean-Noël; Zacho, Helle; Tombal, Bertrand; deSouza, Nandita M.

Use of modern imaging methods to facilitate trials of metastasis-directed therapy for oligometastatic disease in prostate cancer : a consensus recommendation from the EORTC Imaging Group

In: The Lancet Oncology Vol. 19 (2018) Nr. 10, pp. e534 - e545

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Casali, P.G.; Abecassis, N.; Bauer, Sebastian; Biagini, R.; Bielack, S.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Brodowicz, T.; Broto, J.M.; Buonadonna, A.; De Álava, E.; Dei Tos, A.P.; Del Muro, X.G.; Dileo, P.; Eriksson, M.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Ferrari, S.; Frezza, A.M.; Gasperoni, S.; Gelderblom, H.; Gil, T.; Grignani, G.; Gronchi, A.; Haas, R.L.; Hannu, A.; Hassan, B.; Hohenberger, P.; Issels, R.; Joensuu, H.; Jones, R.L.; Judson, I.; Jutte, P.; Kaal, S.; Kasper, B.; Kopeckova, K.; Krákorová, D.A.; Le Cesne, A.; Lugowska, I.; Merimsky, O.; Montemurro, M.; Pantaleo, M.A.; Piana, R.; Picci, P.; Piperno-Neumann, S.; Pousa, A.L.; Reichardt, P.; Robinson, M.H.; Rutkowski, P.; Safwat, A.A.; Schöffski, P.; Sleijfer, S.; Stacchiotti, S.; Sundby Hall, K.; Unk, M.; Van Coevorden, F.; Van Der Graaf, W.; Whelan, J.; Wardelmann, E.; Zaikova, O.; Blay, J.Y.

Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 4, pp. iv68 - iv78

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Wagener, Rabea; López, Cristina; Kleinheinz, Kortine; Bausinger, Julia; Aukema, Sietse M.; Nagel, Inga; Toprak, Umut H.; Seufert, Julian; Altmüller, Janine; Thiele, Holger; Schneider, Christof; Kolarova, Julia; Park, Jeongbin; Hübschmann, Daniel; Murga Penas, Eva M.; Drexler, Hans G.; Attarbaschi, Andishe; Hovland, Randi; Kjeldsen, Eigil; Kneba, Michael; Kontny, Udo; de Leval, Laurence; Nürnberg, Peter; Oschlies, Ilske; Oscier, David; Schlegelberger, Brigitte; Stilgenbauer, Stephan; Wössmann, Wilhelm; Schlesner, Matthias; Burkhardt, Birgit; Klapper, Wolfram; Jaffe, Elaine S.; Küppers, Ralf; Siebert, Reiner

IG-MYC⁺ neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas

In: Blood Vol. 132 (2018) Nr. 21, pp. 2280 - 2285

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Szepanowski, Fabian; Szepanowski, Leon-Phillip; Mausberg, Anne K.; Albrecht, Philipp; Kleinschnitz, Christoph; Kieseier, Bernd C.; Stettner, Mark

Differential impact of pure glyphosate and glyphosate-based herbicide in a model of peripheral nervous system myelination

In: Acta Neuropathologica Vol. 136 (2018) Nr. 6, pp. 979 - 982

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Huckins, L.M.; Hatzikotoulas, K.; Southam, L.; Thornton, L.M.; Steinberg, J.; Aguilera-McKay, F.; Treasure, J.; Schmidt, U.; Gunasinghe, C.; Romero, A.; Curtis, C.; Rhodes, D.; Moens, J.; Kalsi, G.; Dempster, D.; Leung, R.; Keohane, A.; Burghardt, R.; Ehrlich, S.; Hebebrand, Johannes; Hinney, Anke; Ludolph, A.; Walton, E.; Deloukas, P.; Hofman, A.; Palotie, A.; Palta, P.; van Rooij, F.J.A.; Stirrups, K.; Adan, R.; Boni, C.; Cone, R.; Dedoussis, G.; van Furth, E.; Gonidakis, F.; Gorwood, P.; Hudson, J.; Kaprio, J.; Kas, M.; Keski-Rahonen, A.; Kiezebrink, K.; Knudsen, G-P; Maj, M.; Monteleone, A.M.; Monteleone, P.; Raevuori, A.H.; Reichborn-Kjennerud, T.; Tozzi, F.; Tsitsika, A.; van Elburg, A.; Collier, D.A.; Sullivan, P.F.; Breen, G.; Bulik, C.M.; Zeggini, E.

Correction: Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

In: Molecular Psychiatry Vol. 23 (2018) Nr. 9, pp. 1

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Behnke, Kristina; Zhuang, Yuan; Xu, Haifeng C.; Sundaram, Balamurugan; Reich, Maria; Shinde, Prashant V.; Huang, Jun; Modares, Nastaran Fazel; Tumanov, Alexei V.; Polz, Robin; Scheller, Jürgen; Ware, Carl F.; Pfeffer, Klaus; Keitel, Verena; Häussinger, Dieter; Pandyra, Aleksandra A.; Lang, Karl S.; Lang, Philipp A.

B Cell-Mediated Maintenance of Cluster of Differentiation 169–Positive Cells Is Critical for Liver Regeneration

In: Hepatology Vol. 68 (2018) Nr. 6, pp. 2348 - 2361

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Hodi, Frank Stephen; Chiarion-Sileni, Vanna; Gonzalez, Rene; Grob, Jean-Jacques; Rutkowski, Piotr; Cowey, Charles Lance; Lao, Christopher D; Schadendorf, Dirk; Wagstaff, John; Dummer, Reinhard; Ferrucci, Pier Francesco; Smylie, Michael; Hill, Andrew; Hogg, David; Marquez-Rodas, Ivan; Jiang, Joel; Rizzo, Jasmine; Larkin, James; Wolchok, Jedd D

Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067) : 4-year outcomes of a multicentre, randomised, phase 3 trial

In: The Lancet Oncology Vol. 19 (2018) Nr. 11, pp. 1480 - 1492

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Cheung, Phyllis F.; Neff, Florian; Neander, Christian; Bazarna, Anna; Savvatakis, Konstantinos; Liffers, Sven-Thorsten; Althoff, Kristina; Lee, Chang-Lung; Moding, Everett J.; Kirsch, David G.; Saur, Dieter; Bazhin, Alexandr V.; Trajkovic-Arsic, Marija; Heikenwalder, Mathias F.; Siveke, Jens

Notch-induced myeloid reprogramming in spontaneous pancreatic ductal adenocarcinoma by dual genetic targeting

In: Cancer Research Vol. 78 (2018) Nr. 17, pp. 4997 - 5010

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Tucci, Felicia A.; Kitanovski, Simo; Johansson, Patricia; Klein-Hitpaß, Ludger; Kahraman, Alisan; Dürig, Jan; Hoffmann, Daniel; Küppers, Ralf

Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individuals

In: Blood Vol. 131 (2018) Nr. 5, pp. 546 - 557

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Casali, P.G.; Abecassis, N.; Bauer, Sebastian; Biagini, R.; Bielack, S.; Bonvalot, S.; Boukovinas, I.; Bovee, J.V.M.G.; Brodowicz, T.; Broto, J.M.; Buonadonna, A.; De Álava, E.; Dei Tos, A.P.; Del Muro, X.G.; Dileo, P.; Eriksson, M.; Fedenko, A.; Ferraresi, V.; Ferrari, A.; Ferrari, S.; Frezza, A.M.; Gasperoni, S.; Gelderblom, H.; Gil, T.; Grignani, G.; Gronchi, A.; Haas, R.L.; Hannu, A.; Hassan, B.; Hohenberger, P.; Issels, R.; Joensuu, H.; Jones, R.L.; Judson, I.; Jutte, P.; Kaal, S.; Kasper, B.; Kopeckova, K.; Krákorová, D.A.; Le Cesne, A.; Lugowska, I.; Merimsky, O.; Montemurro, M.; Pantaleo, M.A.; Piana, R.; Picci, P.; Piperno-Neumann, S.; Pousa, A.L.; Reichardt, P.; Robinson, M.H.; Rutkowski, P.; Safwat, A.A.; Schöffski, P.; Sleijfer, S.; Stacchiotti, S.; Sundby Hall, K.; Unk, M.; Van Coevorden, F.; Van Der Graaf, W.; Whelan, J.; Wardelmann, E.; Zaikova, O.; Blay, J.Y.

Soft tissue and visceral sarcomas : ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 4, pp. iv51 - iv67

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Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 4774

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Griewank, Klaus G.; Koelsche, Christian; van de Nes, Johannes A. P.; Schrimpf, Daniel; Gessi, Marco; Möller, Inga; Sucker, Antje; Scolyer, Richard A.; Buckland, Michael E.; Murali, Rajmohan; Pietsch, Torsten; Deimling, Andreas von; Schadendorf, Dirk

Integrated genomic classification of melanocytic tumors of the central nervous system using mutation analysis, copy number alterations, and DNA methylation profiling

In: Clinical Cancer Research Vol. 24 (2018) Nr. 18, pp. 4494 - 4504

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Dummer, Reinhard; Ascierto, Paolo A.; Gogas, Helen J.; Arance, Ana; Mandala, Mario; Liszkay, Gabriella; Garbe, Claus; Schadendorf, Dirk; Krajsova, Ivana; Gutzmer, Ralf; Chiarion Sileni, Vanna; Dutriaux, Caroline; de Groot, Jan Willem B.; Yamazaki, Naoya; Loquai, Carmen; Moutouh-de Parseval, Laure A.; Pickard, Michael D.; Sandor, Victor; Robert, Caroline; Flaherty, Keith T.

Overall survival in patients with BRAF-mutant melanoma receiving encorafenib plus binimetinib versus vemurafenib or encorafenib (COLUMBUS) : A multicentre, open-label, randomised, phase 3 trial

In: The Lancet Oncology Vol. 19 (2018) Nr. 10, pp. 1315 - 1327

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Lakatos, Gábor; Lee, K.; Siveke, Jens; Blanc, Jean Frédéric; Macarulla Mercadé, Teresa; Dean, Andrew; Bodoky, Gyorgy; Mirakhur, Beloo; Chen, Jie; Wang-Gillam, Andrea; Chen, Li Li; Jong, Floris A. de

Prognostic value of baseline biliary stents on outcomes in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) in the NAPOLI-1 trial

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 5, pp. v42

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Lollies, Anna; Hartmann, Sylvia; Schneider, Markus; Bracht, Thilo; Weiß, A.L.; Arnolds, Judith; Klein-Hitpaß, Ludger; Sitek, Barbara; Hansmann, Martin Leo; Küppers, Ralf; Weniger, Marc

An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma

In: Leukemia Vol. 32 (2018) Nr. 1, pp. 92 - 101

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Khairnar, Vishal; Duhan, Vikas; Patil, Ashwini M.; Zhou, Fan; Bhat, Hilal; Thoens, Christine; Sharma, Piyush; Adomati, Tom; Friendrich, Sarah-Kim; Bezgovsek, Judith; Dreesen, Janine D.; Wennemuth, Gunther; Westendorf, Astrid; Zelinskyy, Gennadiy; Dittmer, Ulf; Hardt, Cornelia; Timm, Jörg; Göthert, Joachim Rudolf; Lang, Philipp A.; Singer, Bernhard B.; Lang, Karl S.

CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infection

In: Nature Communications Vol. 9 (2018) 2561

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Macurulla Mercade, Teresa; Wang-Gillam, Andrea; Chen, L.; Blanc, Jean Frédéric; Lee, K.; Bodoky, Gyorgy; Dean, Andrew; Chen, Jie; Mirakhur, Beloo; Siveke, Jens; de Jong, Floris A.

The effect of best response to prior anticancer therapy on efficacy outcomes in the NAPOLI-1 trial of patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) previously treated with gemcitabine-based therapy

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 5, pp. v42

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Hemming, M L; Heinrich, M C; Bauer, Sebastian; George, S

Translational Insights into Gastrointestinal Stromal Tumor and Current Clinical Advances

In: Annals of Oncology Vol. 29 (2018) Nr. 10, pp. 2037 - 2045

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Schadendorf, Dirk; Van Akkooi, Alexander; Berking, Carola; Griewank, Klaus; Gutzmer, Ralf; Hauschild, Axel; Stang, Andreas; Rösch, Alexander; Ugurel, Selma

Melanoma

In: Lancet Vol. 392 (2018) Nr. 10151, pp. 971 - 984

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Gulbins, Anne; Schumacher, Fabian; Becker, Katrin Anne; Wilker, Barbara; Soddemann, Matthias; Boldrin, Francesco; Müller, Christian P.; Edwards, Michael J.; Goodman, Michael; Caldwell, Charles C.; Kleuser, Burkhard; Kornhuber, Johannes; Szabo, Ildiko; Gulbins, Erich

Antidepressants regulate autophagy by targeting acid sphingomyelinase

In: Molecular Psychiatry Vol. 23 (2018) Nr. 12, pp. 2251

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Migden, Michael R.; Rischin, Danny; Schmults, Chrysalyne D.; Guminski, Alexander; Hauschild, Axel; Lewis, Karl D.; Chung, Christine H.; Hernandez-Aya, Leonel; Lim, Annette M.; Chang, Anne Lynn S.; Rabinowits, Guilherme; Thai, Alesha A.; Dunn, Lara A.; Hughes, Brett G.M.; Khushalani, Nikhil I.; Modi, Badri; Schadendorf, Dirk; Gao, Bo; Seebach, Frank; Li, Siyu; Li, Jingjin; Mathias, Melissa; Booth, Jocelyn; Mohan, Kosalai; Stankevich, Elizabeth; Babiker, Hani M.; Brana, Irene; Gil-Martin, Marta; Homsi, Jade; Johnson, Melissa L.; Moreno, Victor; Niu, Jiaxin; Owonikoko, Taofeek K.; Papadopoulos, Kyriakos P.; Yancopoulos, George D.; Lowy, Israel; Fury, Matthew G.

PD-1 blockade with cemiplimab in advanced cutaneous squamous-cell carcinoma

In: The New England Journal of Medicine Vol. 379 (2018) Nr. 4, pp. 341 - 351

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Ackermann, Sandra; Cartolano, Maria; Hero, Barbara; Welte, Anne; Kahlert, Yvonne; Roderwieser, Andrea; Bartenhagen, Christoph; Walter, Esther; Gecht, Judith; Kerschke, Laura; Volland, Ruth; Menon, Roopika; Heuckmann, Johannes M.; Gartlgruber, Moritz; Hartlieb, Sabine; Henrich, Kai-Oliver; Okonechnikov, Konstantin; Altmüller, Janine; Nürnberg, Peter; Lefever, Steve; De Wilde, Bram; Sand, Frederik; Ikram, Fakhera; Rosswog, Carolina; Fischer, Janina; Theissen, Jessica; Hertwig, Falk; Singhi, Aatur D.; Simon, Thorsten; Vogel, Wenzel; Perner, Sven; Krug, Barbara; Schmidt, Matthias; Rahmann, Sven; Achter, Viktor; Lang, Ulrich; Vokuhl, Christian; Ortmann, Monika; Büttner, Reinhard; Eggert, Angelika; Speleman, Frank; O’Sullivan, Roderick J.; Thomas, Roman K.; Berthold, Frank; Vandesompele, Jo; Schramm, Alexander; Westermann, Frank; Schulte, Johannes; Peifer, Martin; Fischer, Matthias

A mechanistic classification of clinical phenotypes in neuroblastoma

In: Science Vol. 362 (2018) Nr. 6419, pp. 1165 - 1170

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Jerby-Arnon, Livnat; Shah, Parin; Cuoco, Michael S.; Rodman, Christopher; Su, Mei-Ju; Melms, Johannes C.; Leeson, Rachel; Kanodia, Abhay; Mei, Shaolin; Lin, Jia-Ren; Wang, Shu; Rabasha, Bokang; Liu, David; Zhang, Gao; Margolais, Claire; Ashenberg, Orr; Ott, Patrick A.; Buchbinder, Elizabeth I.; Haq, Rizwan; Hodi, F. Stephen; Boland, Genevieve M.; Sullivan, Ryan J.; Frederick, Dennie T.; Miao, Benchun; Moll, Tabea; Flaherty, Keith T.; Herlyn, Meenhard; Jenkins, Russell W.; Thummalapalli, Rohit; Kowalczyk, Monika S.; Cañadas, Israel; Schilling, Bastian; Cartwright, Adam N.R.; Luoma, Adrienne M.; Malu, Shruti; Hwu, Patrick; Bernatchez, Chantale; Forget, Marie-Andrée; Barbie, David A.; Shalek, Alex K.; Tirosh, Itay; Sorger, Peter K.; Wucherpfennig, Kai; Van Allen, Eliezer M.; Schadendorf, Dirk; Johnson, Bruce E.; Rotem, Asaf; Rozenblatt-Rosen, Orit; Garraway, Levi A.; Yoon, Charles H.; Izar, Benjamin; Regev, Aviv

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

In: Cell Vol. 175 (2018) Nr. 4, pp. 984 - 997.e24

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Schöffski, Patrick; Wozniak, A.; Kasper, B.; Aamdal, S.; Leahy, M.G.; Rutkowski, P.; Bauer, Sebastian; Gelderblom, H.; Italiano, A.; Lindner, L.H.; Hennig, I.; Strauss, S.; Zakotnik, B.; Anthoney, A.; Albiges, L.; Blay, J.-Y.; Reichardt, P.; Sufliarsky, J.; van der Graaf, W.T.A.; Debiec-Rychter, M.; Sciot, R.; Van Cann, T.; Marréaud, S.; Raveloarivahy, T.; Collette, S.; Stacchiotti, S.

Activity and safety of crizotinib in patients with alveolar soft part sarcoma with rearrangement of TFE3 : European Organization for Research and Treatment of Cancer (EORTC) phase II trial 90101 'CREATE'

In: Annals of Oncology Vol. 29 (2018) Nr. 3, pp. 758 - 765

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Mahabadi, Amir Abbas; Rassaf, Tienush

Imaging of coronary inflammation for cardiovascular risk prediction

In: Lancet Vol. 392 (2018) Nr. 10151, pp. 894 - 896

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Lang, Stephan; Bruderek, Kirsten; Kaspar, Cordelia; Höing, Benedikt; Kanaan, Oliver; Dominas, Nina; Hussain, Timon; Droege, Freya; Eyth, Christian; Hadaschik, Boris; Brandau, Sven

Clinical Relevance and Suppressive Capacity of Human Myeloid-Derived Suppressor Cell Subsets

In: Clinical Cancer Research Vol. 24 (2018) Nr. 19, pp. 4834 - 4844

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Gulbins, Anne; Schumacher, Fabian; Becker, Katrin Anne; Wilker, Barbara; Soddemann, Matthias; Boldrin, Francesco; Müller, Christian P.; Edwards, Michael J.; Goodman, Michael; Caldwell, Charles C.; Kleuser, Burkhard; Kornhuber, Johannes; Szabo, Ildiko; Gulbins, Erich

Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide

In: Molecular Psychiatry Vol. 23 (2018) Nr. 12, pp. 2324 - 2346

Online Full Text: dx.doi.org/ (Open Access)
Bentzen, Amalie K.; Such, Lina; Jensen, Kamilla K.; Marquard, Andrea M.; Jessen, Leon E.; Miller, Natalie J.; Church, Candice D.; Lyngaa, Rikke; Koelle, David M.; Becker, Jürgen; Linnemann, Carsten; Schumacher, Ton N. M.; Marcatili, Paolo; Nghiem, Paul; Nielsen, Morten; Hadrup, Sine R.

T cell receptor fingerprinting enables in-depth characterization of the interactions governing recognition of peptide–MHC complexes

In: Nature Biotechnology Vol. 36 (2018) Nr. 12, pp. 1191 - 1196

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Huckins, L.M.; Hatzikotoulas, K.; Southam, L.; Thornton, L.M.; Steinberg, J.; Aguilera-Mckay, F.; Treasure, J.; Schmidt, U.; Gunasinghe, C.; Romero, A.; Curtis, C.; Rhodes, D.; Moens, J.; Kalsi, G.; Dempster, D.; Leung, R.; Keohane, A.; Burghardt, R.; Ehrlich, S.; Hebebrand, Johannes; Hinney, Anke; Ludolph, A.; Walton, E.; Deloukas, P.; Hofman, A.; Palotie, A.; Palta, P.; Van Rooij, F.J.A.; Stirrups, K.; Adan, R.; Boni, C.; Cone, R.; Dedoussis, G.; Van Furth, E.; Gonidakis, F.; Gorwood, P.; Hudson, J.; Kaprio, J.; Kas, M.; Keski-Rahonen, A.; Kiezebrink, K.; Knudsen, G.-P.; Slof-Op 'T Landt, M.C.T.; Maj, M.; Monteleone, A.M.; Monteleone, P.; Raevuori, A.H.; Reichborn-Kjennerud, T.; Tozzi, F.; Tsitsika, A.; Van Elburg, A.; Collier, D.A.; Sullivan, P.F.; Breen, G.; Bulik, C.M.; Zeggini, E.

Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

In: Molecular Psychiatry Vol. 23 (2018) Nr. 5, pp. 1169 - 1180

Online Full Text: dx.doi.org/ (Open Access)
Shen, Fang; Li, Yaming; Wang, Yang; Sozzi, Vitina; Revill, Peter A.; Liu, Jiangxia; Gao, Lu; Yang, Guang; Lu, Mengji; Sutter, Kathrin; Dittmer, Ulf; Chen, Jieliang; Yuan, Zhenghong

Hepatitis B virus sensitivity to interferon-α in hepatocytes is more associated with cellular interferon response than with viral genotype

In: Hepatology Vol. 67 (2018) Nr. 4, pp. 1237 - 1252

Online Full Text: dx.doi.org/ (Open Access)
Bezrookove, Vladimir; Nosrati, Mehdi; Miller, James R.; De Semir, David; Dar, Altaf A.; Vosoughi, Elham; Vaquero, Edith; Sucker, Antje; Lazar, Alexander J.; Gershenwald, Jeffrey E.; Davies, Michael A.; Schadendorf, Dirk; Kashani-Sabet, Mohammed

Role of elevated PHIP copy number as a prognostic and progression marker for cutaneous melanoma

In: Clinical Cancer Research Vol. 24 (2018) Nr. 17, pp. 4119 - 4125

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Bauer, Sebastian; George, Suzanne; Kang, Y.-K.; Tap, William D.; Zhou, T.; Picazio, N.; Boral, Andy L.; Heinrich, Michael

VOYAGER : An open-label, randomised, phase III study of avapritinib vs regorafenib in patients (pts) with locally advanced (adv) metastatic or unresectable gastrointestinal stromal tumour (GIST)

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii595

Online Full Text: dx.doi.org/ (Open Access)
Long, Georgina V.; Hauschild, Axel; Santinami, Mario; Atkinson, Victoria G.; Mandala, Mario; Chiarion-Sileni, Vanna; Larkin, James M. G.; Robert, Caroline; Schadendorf, Dirk; Dasgupta, Kohinoor; Shilkrut, Mark; Garrett, James; Brase, Jan C.; Kefford, Rick F.; Kirkwood, John M.; Dummer, Reinhard G.

Updated relapse-free survival (RFS) and biomarker analysis in the COMBI-AD trial of adjuvant dabrafenib + trametinib (D + T) in patients (pts) with resected BRAF V600-mutant stage III melanoma

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8, pp. viii734 - viii735

Online Full Text: dx.doi.org/ (Open Access)
Miao, Diana; Margolis, Claire A.; Vokes, Natalie I.; Liu, David; Taylor-Weiner, Amaro; Wankowicz, Stephanie M.; Adeegbe, Dennis; Keliher, Daniel; Schilling, Bastian; Tracy, Adam; Manos, Michael; Chau, Nicole G.; Hanna, Glenn J.; Polak, Paz; Rodig, Scott J.; Signoretti, Sabina; Sholl, Lynette M.; Engelman, Jeffrey A.; Getz, Gad; Jänne, Pasi A.; Haddad, Robert I.; Choueiri, Toni K.; Barbie, David A.; Haq, Rizwan; Awad, Mark M.; Schadendorf, Dirk; Hodi, F. Stephen; Bellmunt, Joaquim; Wong, Kwok-Kin; Hammerman, Peter; Van Allen, Eliezer M.

Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors

In: Nature Genetics Vol. 50 (2018) Nr. 9, pp. 1271 - 1281

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Moonens, Kristof; Hamway, Youssef; Neddermann, Matthias; Reschke, Marc; Tegtmeyer, Nicole; Kruse, Tobias; Kammerer, Robert; Mejías-Luque, Raquel; Singer, Bernhard B.; Backert, Steffen; Gerhard, Markus; Remaut, Han

Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs

In: The EMBO Journal Vol. 37 (2018) Nr. 13,

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Schadendorf, Dirk; et.al.

Updated relapse-free survival (RFS) and biomarker analysis in the COMBI-AD trial of adjuvant dabrafenib plus trametinib (D plus T) in patients (pts) with resected BRAF V600-mutant stage III melanoma

In: Annals of Oncology Vol. 29 (2018) Nr. Suppl. 8,
Eggermont, Alexander M.M.; Blank, Christian U.; Mandala, Mario; Long, Georgina V.; Atkinson, Victoria; Dalle, Stéphane; Haydon, Andrew; Lichinitser, Mikhail; Khattak, Adnan; Carlino, Matteo S.; Sandhu, Shahneen; Larkin, James; Puig, Susana; Ascierto, Paolo A.; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Maio, Michele; Van Den Eertwegh, Alfonsus J. M.; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; Lorigan, Paul; Ibrahim, Nageatte; Marreaud, Sandrine; Van Akkooi, Alexander C. J.; Suciu, Stefan; Robert, Caroline

Adjuvant pembrolizumab versus placebo in resected stage III melanoma

In: The New England Journal of Medicine Vol. 378 (2018) Nr. 19, pp. 1789 - 1801

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
ter Veer, Emil; van Rijssen, L. Bengt; Besselink, Marc G.; Mali, Rosa M. A.; Berlin, Jordan D.; Boeck, Stefan; Bonnetain, Franck; Chau, Ian; Conroy, Thierry; Van Cutsem, Eric; Deplanque, Gael; Friess, Helmut; Glimelius, Bengt; Goldstein, David; Herrmann, Richard; Labianca, Roberto; Van Laethem, Jean-Luc; Macarulla, Teresa; van der Meer, Jonathan H. M.; Neoptolemos, John P.; Okusaka, Takuji; O'Reilly, Eileen M.; Pelzer, Uwe; Philip, Philip A.; van der Poel, Marcel J.; Reni, Michele; Scheithauer, Werner; Siveke, Jens; Verslype, Chris; Busch, Olivier R.; Wilmink, Johanna W.; van Oijen, Martijn G. H.; van Laarhoven, Hanneke W. M.

Consensus statement on mandatory measurements in pancreatic cancer trials (COMM-PACT) for systemic treatment of unresectable disease

In: The Lancet Oncology Vol. 19 (2018) Nr. 3, pp. e151 - e160

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Dummer, Reinhard; Ascierto, Paolo A; Gogas, Helen J; Arance, Ana; Mandala, Mario; Liszkay, Gabriella; Garbe, Claus; Schadendorf, Dirk; Krajsova, Ivana; Gutzmer, Ralf; Chiarion-Sileni, Vanna; Dutriaux, Caroline; de Groot, Jan Willem B; Yamazaki, Naoya; Loquai, Carmen; Moutouh-de Parseval, Laure A; Pickard, Michael D; Sandor, Victor; Robert, Caroline; Flaherty, Keith T

Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS) : a multicentre, open-label, randomised phase 3 trial

In: The Lancet Oncology Vol. 19 (2018) Nr. 5, pp. 603 - 615

Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
Küppers, Ralf; Stevenson, Freda K.

Critical influences on the pathogenesis of follicular lymphoma

In: Blood Vol. 131 (2018) Nr. 21, pp. 2297 - 2306

Online Full Text: dx.doi.org/ (Open Access)
Schmidt, Stefan; Linge, Annett; Zwanenburg, Alex; Leger, Stefan; Lohaus, Fabian; Krenn, Constanze; Appold, Steffen; Gudziol, Volker; Nowak, Alexander; von Neubeck, Cläre; Tinhofer, Inge; Budach, Volker; Sak, Ali; Stuschke, Martin; Balermpas, Panagiotis; Rodel, Claus; Bunea, Hatice; Grosu, Anca-Ligia; Abdollahi, Amir; Debus, Jurgen; Ganswindt, Ute; Belka, Claus; Pigorsch, Steffi; Combs, Stephanie E.; Monnich, David; Zips, Daniel; Baretton, Gustavo B.; Buchholz, Frank; Baumann, Michael; Krause, Mechthild; Lock, Steffen

Development and Validation of a Gene Signature for Patients with Head and Neck Carcinomas Treated by Postoperative Radio(chemo)therapy

In: Clinical Cancer Research Vol. 24 (2018) Nr. 6, pp. 1364 - 1374

Online Full Text: dx.doi.org/ (Open Access)
Gröbner, Susanne N.; Worst, Barbara C.; Weischenfeldt, Joachim; Buchhalter, Ivo; Kleinheinz, Kortine; Rudneva, Vasilisa A.; Johann, Pascal D.; Balasubramanian, Gnana Prakash; Segura-Wang, Maia; Brabetz, Sebastian; Bender, Sebastian; Hutter, Barbara; Sturm, Dominik; Pfaff, Elke; Hübschmann, Daniel; Zipprich, Gideon; Heinold, Michael; Eils, Jürgen; Lawerenz, Christian; Erkek, Serap; Lambo, Sander; Waszak, Sebastian; Blattmann, Claudia; Borkhardt, Arndt; Kuhlen, Michaela; Eggert, Angelika; Fulda, Simone; Gessler, Manfred; Wegert, Jenny; Kappler, Roland; Baumhoer, Daniel; Burdach, Stefan; Kirschner-Schwabe, Renate; Kontny, Udo; Kulozik, Andreas E.; Lohmann, Dietmar; Hettmer, Simone; Eckert, Cornelia; Bielack, Stefan; Nathrath, Michaela; Niemeyer, Charlotte; Richter, Günther H.; Schulte, Johannes; Siebert, Reiner; Westermann, Frank; Molenaar, Jan J.; Vassal, Gilles; Witt, Hendrik; Zapatka, Marc; Burkhardt, Birgit; Kratz, Christian P.; Witt, Olaf; Tilburg, Cornelis M. Van; Kramm, Christof M.; Fleischhack, Gudrun; Dirksen, Uta; Rutkowski, Stefan; Frühwald, Michael; Hoff, Katja Von; Wolf, Stephan; Klingebiel, Thomas; Koscielniak, Ewa; Landgraf, Pablo; Koster, Jan; Resnick, Adam C.; Zhang, Jinghui; Liu, Yanling; Zhou, Xin; Waanders, Angela J.; Zwijnenburg, Danny A.; Raman, Pichai; Brors, Benedikt; Weber, Ursula D.; Northcott, Paul A.; Pajtler, Kristian; Kool, Marcel; Piro, Rosario M.; Korbel, Jan O.; Schlesner, Matthias; Eils, Roland; Jones, David T. W.; Lichter, Peter; Chavez, Lukas; Pfister, Stefan M.

The landscape of genomic alterations across childhood cancers

In: Nature Vol. 555 (2018) Nr. 7696, pp. 321 - 327

Online Full Text: dx.doi.org/ (Open Access)
McQuade, Jennifer L; Daniel, Carrie R; Hess, Kenneth R; Mak, Carmen; Wang, Daniel Y; Rai, Rajat R; Park, John J; Haydu, Lauren E; Spencer, Christine; Wongchenko, Matthew; Lane, Stephen; Lee, Dung-Yang; Kaper, Mathilde; McKean, Meredith; Beckermann, Kathryn E; Rubinstein, Samuel M; Rooney, Isabelle; Musib, Luna; Budha, Nageshwar; Hsu, Jessie; Nowicki, Theodore S; Avila, Alexandre; Haas, Tomas; Puligandla, Maneka; Lee, Sandra; Fang, Shenying; Wargo, Jennifer A; Gershenwald, Jeffrey E; Lee, Jeffrey E; Hwu, Patrick; Chapman, Paul B; Sosman, Jeffrey A; Schadendorf, Dirk; Grob, Jean-Jacques; Flaherty, Keith T; Walker, Dana; Yan, Yibing; McKenna, Edward; Legos, Jeffrey J; Carlino, Matteo S; Ribas, Antoni; Kirkwood, John M; Long, Georgina V; Johnson, Douglas B; Menzies, Alexander M; Davies, Michael A

Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy : a retrospective, multicohort analysis

In: The Lancet Oncology Vol. 19 (2018) Nr. 3, pp. 310 - 322

Online Full Text: dx.doi.org/ Online Full Text (Open Access)
Capper, David; Jones, David T. W.; Sill, Martin; Hovestadt, Volker; Schrimpf, Daniel; Sturm, Dominik; Koelsche, Christian; Sahm, Felix; Chavez, Lukas; Reuss, David E.; Kratz, Annekathrin; Wefers, Annika K.; Huang, Kristin; Pajtler, Kristian; Schweizer, Leonille; Stichel, Damian; Olar, Adriana; Engel, Nils W.; Lindenberg, Kerstin; Harter, Patrick N.; Braczynski, Anne K.; Plate, Karl H.; Dohmen, Hildegard; Garvalov, Boyan K.; Coras, Roland; Hölsken, Annett; Hewer, Ekkehard; Bewerunge-Hudler, Melanie; Schick, Matthias; Fischer, Roger; Beschorner, Rudi; Schittenhelm, Jens; Staszewski, Ori; Wani, Khalida; Varlet, Pascale; Pages, Melanie; Temming, Petra; Lohmann, Dietmar; Selt, Florian; Witt, Hendrik; Milde, Till; Witt, Olaf; Aronica, Eleonora; Giangaspero, Felice; Rushing, Elisabeth; Scheurlen, Wolfram; Geisenberger, Christoph; Rodriguez, Fausto J.; Becker, Albert; Preusser, Matthias; Haberler, Christine; Bjerkvig, Rolf; Cryan, Jane; Farrell, Michael; Deckert, Martina; Hench, Jürgen; Frank, Stephan; Serrano, Jonathan; Kannan, Kasthuri; Tsirigos, Aristotelis; Brück, Wolfgang; Hofer, Silvia; Brehmer, Stefanie; Seiz-Rosenhagen, Marcel; Hänggi, Daniel; Hans, Volkmar; Rozsnoki, Stephanie; Hansford, Jordan R.; Kohlhof, Patricia; Kristensen, Bjarne W.; Lechner, Matt; Lopes, Beatriz; Mawrin, Christian; Ketter, Ralf; Kulozik, Andreas; Khatib, Ziad; Heppner, Frank; Koch, Arend; Jouvet, Anne; Keohane, Catherine; Mühleisen, Helmut; Mueller, Wolf; Pohl, Ute; Prinz, Marco; Benner, Axel; Zapatka, Marc; Gottardo, Nicholas G.; Driever, Pablo Hernáiz; Kramm, Christof M.; Müller, Hermann L.; Rutkowski, Stefan; Von Hoff, Katja; Frühwald, Michael C.; Gnekow, Astrid; Fleischhack, Gudrun; Tippelt, Stephan; Calaminus, Gabriele; Monoranu, Camelia-Maria; Perry, Arie; Jones, Chris; Jacques, Thomas S.; Radlwimmer, Bernhard; Gessi, Marco; Pietsch, Torsten; Schramm, Johannes; Schackert, Gabriele; Westphal, Manfred; Reifenberger, Guido; Wesseling, Pieter; Weller, Michael; Collins, Vincent Peter; Blümcke, Ingmar; Bendszus, Martin; Debus, Jürgen; Huang, Annie; Jabado, Nada; Northcott, Paul A.; Paulus, Werner; Gajjar, Amar; Robinson, Giles W.; Taylor, Michael D.; Jaunmuktane, Zane; Ryzhova, Marina; Platten, Michael; Unterberg, Andreas; Wick, Wolfgang; Karajannis, Matthias A.; Mittelbronn, Michel; Acker, Till; Hartmann, Christian; Aldape, Kenneth; Schüller, Ulrich; Buslei, Rolf; Lichter, Peter; Kool, Marcel; Herold-Mende, Christel; Ellison, David W.; Hasselblatt, Martin; Snuderl, Matija; Brandner, Sebastian; Korshunov, Andrey; Von Deimling, Andreas; Pfister, Stefan M.

DNA methylation-based classification of central nervous system tumours

In: Nature Vol. 555 (2018) Nr. 7697, pp. 469 - 474

Online Full Text: dx.doi.org/ (Open Access)
Chudasama, Priya; Mughal, Sadaf S.; Schröck, Evelin; Glimm, Hanno; Kleinheinz, Kortine; Klink, Barbara; Brors, Benedikt; Hlevnjak, Mario; Gröschel, Stefan; Wolf, Stephan; Omlor, Georg; Ernst, Aurélie; Ulrich, Alexis; Deeg, Katharina I.; Mechtersheimer, Gunhild; Schimmack, Simon; Eils, Roland; Egerer, Gerlinde; Kasper, Bernd; Wong, Siao-Han; von Kalle, Christof; Hohenberger, Peter; Lehner, Burkhard; Rippe, Karsten; Chung, Inn; Bauer, Sebastian; Scholl, Claudia; Sieverling, Lina; Sanders, Mathijs A.; Hübschmann, Daniel; Heilig, Christoph E.; Hutter, Barbara; Renner, Marcus; Weichert, Wilko; Stenzinger, Albrecht; Schlesner, Matthias; Hoogenboezem, Remco M.; Kopp, Hans-Georg; Rabe, Sophie; Zapatka, Marc; Fröhling, Stefan

Integrative genomic and transcriptomic analysis of leiomyosarcoma

In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 144

Online Full Text: dx.doi.org/ (Open Access)
Becker-Flegler, Katrin; Riethmüller, Joachim; Seitz, Aaron P.; Gardner, Aaron; Boudreau, Ryan; Kamler, Markus; Kleuser, Burkhard; Schuchman, Edward; Caldwell, Charles C.; Edwards, Michael J.; Grassmé, Heike; Brodlie, Malcolm; Gulbins, Erich

Sphingolipids as targets for inhalation treatment of cystic fibrosis

In: Advanced Drug Delivery Reviews Vol. 133 (2018) pp. 66 - 75

Online Full Text: dx.doi.org/
van Dinther, Dieke; Veninga, Henrike; Iborra, Salvador; Borg, Ellen G.F.; Hoogterp, Leoni; Olesek, Katarzyna; Beijer, Marieke R.; Schetters, Sjoerd T.T.; Kalay, Hakan; Garcia-Vallejo, Juan J.; Franken, Kees L.; Cham, Lamin B.; Lang, Karl S.; van Kooyk, Yvette; Sancho, David; Crocker, Paul R.; den Haan, Joke M.M.

Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T Cell Cross-Priming

In: Cell Reports Vol. 22 (2018) Nr. 6, pp. 1484 - 1495

Online Full Text: dx.doi.org/ (Open Access)

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