ZMB Member Karl Sebastian Lang

ZMB Member
Karl Sebastian Lang

Next ZMB-Member
portrait photo of ZMB member Karl Sebastian Lang
© Lang

Prof. Dr. Karl Sebastian Lang

University Hospital Essen
Hufelandstr. 55
45122 Essen

Research Overview

The group of Prof. Lang studies molecular and cellular immunological mechanisms which can influence the outcome of human disease. This includes immunopathology occurring during autoimmune disease, infectious disease, tumor disease and transplantation. Mainly immunological models are used for these studies.

The following models are currently used:

  • Lmphocytic choriomeningitis virus (LCMV)
  • Vesicular stomatitis Virus (VSV)
  • Listeria monocytogenes
  • RIP-GP model (Autoimmune diabetes)
  • B16 melanoma model
Read more

Selected Publications

    Journal articles

  • Xavier, Serene; Nguyen, Vivian; Khairnar, Vishal; Phan, An; Yang, Lu; Nelson, Michael S.; Shukla, Ravi P.; Wang, Jinhui; Li, Aimin; Geng, Huimin; Lee, Jaewoong; Sadras, Teresa; Pham, Lan V.; Weisenburger, Dennis D.; Chan, Wing C.; Lang, Karl S.; Shouse, Geoffrey P.; Danilov, Alexey V.; Song, Joo Y.; Parekh, Samir; Müschen, Markus; Ngo, Vu N.
    CEACAM1 as a mediator of B-cell receptor signaling in mantle cell lymphoma
    In: Nature Communications , Vol. 16 2025, Nr. 1, 4967
  • Liu, Wei; Stachura, Paweł; Xu, Haifeng C.; Váraljai, Renáta; Shinde, Prashant; Ganesh, Nikkitha Umesh; Mack, Matthias; Van Lierop, Anke; Huang, Anfei; Sundaram, Balamurugan; Lang, Karl S.; Picard, Daniel; Fischer, Ute; Remke, Marc; Homey, Bernhard; Rösch, Alexander; Häussinger, Dieter; Lang, Philipp A.; Borkhardt, Arndt; Pandyra, Aleksandra A.; Stachura, Pawel; Umesh Ganesh, Nikkitha
    BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment
    In: Cancer Research , Vol. 82 2022, Nr. 2, pp. 264 – 277
  • Cheung, Phyllis F.; Yang, JiaJin; Fang, Rui; Borgers, Arianna; Krengel, Kirsten; Stoffel, Anne; Althoff, Kristina; Yip, Chi Wai; Siu, Elaine H. L.; Ng, Linda W. C.; Lang, Karl S.; Cham, Lamin B.; Engel, Daniel Robert; Soun, Camille; Cima, Igor; Scheffler, Björn; Striefler, Jana K.; Sinn, Marianne; Bahra, Marcus; Pelzer, Uwe; Oettle, Helmut; Markus, Peter; Smeets, Esther M. M.; Aarntzen, Erik H. J. G.; Savvatakis, Konstantinos; Liffers, Sven-Thorsten; Lueong, Smiths S.; Neander, Christian; Bazarna, Anna; Zhang, Xin; Paschen, Annette; Crawford, Howard C.; Chan, Anthony W. H.; Cheung, Siu Tim; Siveke, Jens
    Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression
    In: Nature Communications , Vol. 13 2022, Nr. 1, 156
  • Cappello, Sabrina; Sung, Hsu-Min; Ickes, Christian; Gibhardt, Christine S.; Vultur, Adina; Bhat, Hilal; Hu, Zhongwen; Brafford, Patricia; Denger, Andreas; Stejerean-Todoran, Ioana; Köhn, Rixa-Mareike; Lorenz, Verena; Künzel, Nicolas; Salinas, Gabriela; Stanisz, Hedwig; Legler, Tobias; Rehling, Peter; Schön, Michael P.; Lang, Karl S.; Helms, Volkhard; Herlyn, Meenhard; Hoth, Markus; Kummerow, Carsten; Bogeski, Ivan
    Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to Immunotherapies
    In: Cancer Research , Vol. 81 2021, Nr. 21, pp. 5540 – 5554
  • Namineni, Sukumar; O'Connor, Tracy; Faure-Dupuy, Suzanne; Johansen, Pål; Riedl, Tobias; Liu, Kaijing; Xu, Haifeng; Singh, Indrabahadur; Shinde, Prashant; Li, Fanghui; Pandyra, Aleksandra; Sharma, Piyush; Ringelhan, Marc; Muschaweckh, Andreas; Borst, Katharina; Blank, Patrick; Lampl, Sandra; Neuhaus, Katharina; Durantel, David; Farhat, Rayan; Weber, Achim; Lenggenhager, Daniela; Kündig, Thomas M.; Staeheli, Peter; Protzer, Ulrike; Wohlleber, Dirk; Holzmann, Bernhard; Binder, Marco; Breuhahn, Kai; Assmus, Lisa Mareike; Nattermann, Jacob; Abdullah, Zeinab; Rolland, Maude; Dejardin, Emmanuel; Lang, Philipp A.; Lang, Karl S.; Karin, Michael; Lucifora, Julie; Kalinke, Ulrich; Knolle, Percy A.; Heikenwalder, Mathias
    A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control
    In: Journal of Hepatology , Vol. 72 2020, Nr. 5, pp. 960 – 975
  • Lang, Judith; Bohn, Patrick; Bhat, Hilal; Jastrow, Holger; Walkenfort, Bernd; Cansiz, Feyza; Fink, Julian; Bauer, Michael; Olszewski, Dominik; Ramos-Nascimento, Ana; Duhan, Vikas; Friedrich, Sarah-Kim; Becker-Flegler, Katrin; Krawczyk, Adalbert; Edwards, Michael J.; Burchert, Andreas; Huber, Magdalena; Friebus-Kardash, Justa; Göthert, Joachim Rudolf; Hardt, Cornelia; Probst, Hans Christian; Schumacher, Fabian; Köhrer, Karl; Kleuser, Burkhard; Babiychuk, Eduard B.; Sodeik, Beate; Seibel, Jürgen; Greber, Urs F.; Lang, Philipp A.; Gulbins, Erich; Lang, Karl S.
    Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease
    In: Nature Communications , Vol. 11 2020, Nr. 1, pp. 1338
  • Zhuang, Yuan; Xu, Haifeng C.; Shinde, Prashant V.; Warfsmann, Jens; Vasilevska, Jelena; Sundaram, Balamurugan; Behnke, Kristina; Huang, Jun; Hoell, Jessica I.; Borkhardt, Arndt; Pfeffer, Klaus; Taha, Mohamed S.; Herebian, Diran; Mayatepek, Ertan; Brenner, Dirk; Ahmadian, Mohammad Reza; Keitel, Verena; Wieczorek, Dagmar; Häussinger, Dieter; Pandyra, Aleksandra A.; Lang, Karl S.; Lang, Philipp A.
    Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury
    In: Gut , Vol. 69 2020, Nr. 1, pp. 133 – 145
  • Beyer, Marc; Abdullah, Zeinab; Chemnitz, Jens M.; Maisel, Daniela; Sander, Jil; Lehmann, Clara; Thabet, Yasser; Shinde, Prashant V.; Schmidleithner, Lisa; Köhne, Maren; Trebicka, Jonel; Schierwagen, Robert; Hofmann, Andrea; Popov, Alexey; Lang, Karl S.; Oxenius, Annette; Buch, Thorsten; Kurts, Christian; Heikenwalder, Mathias; Fätkenheuer, Gerd; Lang, Philipp A.; Hartmann, Pia; Knolle, Percy A.; Schultze, Joachim L.
    Publisher Correction: Tumor-necrosis factor impairs CD4⁺ T cell–mediated immunological control in chronic viral infection
    In: Nature Immunology , Vol. 21 2020, Nr. 9, pp. 1135
  • Behnke, Kristina; Zhuang, Yuan; Xu, Haifeng C.; Sundaram, Balamurugan; Reich, Maria; Shinde, Prashant V.; Huang, Jun; Modares, Nastaran Fazel; Tumanov, Alexei V.; Polz, Robin; Scheller, Jürgen; Ware, Carl F.; Pfeffer, Klaus; Keitel, Verena; Häussinger, Dieter; Pandyra, Aleksandra A.; Lang, Karl S.; Lang, Philipp A.
    Reply [Letter to the Editor: Characterization of CD169+ Macrophages in Liver Regeneration: Tissue Distribution and Fate?]
    In: Hepatology , Vol. 70 2019, Nr. 3, pp. 1074 – 1075
  • Behnke, Kristina; Zhuang, Yuan; Xu, Haifeng C.; Sundaram, Balamurugan; Reich, Maria; Shinde, Prashant V.; Huang, Jun; Modares, Nastaran Fazel; Tumanov, Alexei V.; Polz, Robin; Scheller, Jürgen; Ware, Carl F.; Pfeffer, Klaus; Keitel, Verena; Häussinger, Dieter; Pandyra, Aleksandra A.; Lang, Karl S.; Lang, Philipp A.
    B Cell-Mediated Maintenance of Cluster of Differentiation 169–Positive Cells Is Critical for Liver Regeneration
    In: Hepatology , Vol. 68 2018, Nr. 6, pp. 2348 – 2361
  • Khairnar, Vishal; Duhan, Vikas; Patil, Ashwini M.; Zhou, Fan; Bhat, Hilal; Thoens, Christine; Sharma, Piyush; Adomati, Tom; Friendrich, Sarah-Kim; Bezgovsek, Judith; Dreesen, Janine D.; Wennemuth, Gunther; Westendorf, Astrid; Zelinskyy, Gennadiy; Dittmer, Ulf; Hardt, Cornelia; Timm, Jörg; Göthert, Joachim Rudolf; Lang, Philipp A.; Singer, Bernhard B.; Lang, Karl S.
    CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infection
    In: Nature Communications , Vol. 9 2018, 2561
  • Horst, Andrea Kristina; Wegscheid, Claudia; Schaefers, Christoph; Schiller, Birgit; Neumann, Katrin; Lunemann, Sebastian; Langeneckert, Annika E; Oldhafer, Karl J; Weiler-Normann, Christina; Lang, Karl S.; Singer, Bernhard B.; Altfeld, Marcus; Diehl, Linda; Tiegs, Gisa
    Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice
    In: Hepatology , Vol. 68 2018, Nr. 1, pp. 200 – 214
  • Kalkavan, Halime; Sharma, Piyush; Kasper, Stefan; Helfrich, Iris; Pandyra, Aleksandra A.; Gassa, Asmae; Virchow, Isabel; Flatz, Lukas; Brandenburg, Tim; Namineni, Sukumar; Heikenwalder, Mathias; Höchst, Bastian; Knolle, Percy A.; Wollmann, Guido; Von Laer, Dorothee; Drexler, Ingo; Rathbun, Jessica; Cannon, Paula M.; Scheu, Stefanie; Bauer, Jens; Chauhan, Jagat; Häussinger, Dieter; Willimsky, Gerald; Löhning, Max; Schadendorf, Dirk; Brandau, Sven; Schuler, Martin; Lang, Philipp A.; Lang, Karl S.
    Spatiotemporally restricted arenavirus replication induces immune surveillance and type i interferon-dependent tumour regression
    In: Nature Communications , Vol. 8 2017, pp. 14447
  • Beyer, Marc; Abdullah, Zeinab; Chemnitz, Jens M; Maisel, Daniela; Sander, Jil; Lehmann, Clara; Thabet, Yasser; Shinde, Prashant V; Schmidleithner, Lisa; Köhne, Maren; Trebicka, Jonel; Schierwagen, Robert; Hofmann, Andrea; Popov, Alexey; Lang, Karl S.; Oxenius, Annette; Buch, Thorsten; Kurts, Christian; Heikenwalder, Mathias; Fätkenheuer, Gerd; Lang, Philipp A; Hartmann, Pia; Knolle, Percy A; Schultze, Joachim L
    Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection
    In: Nature Immunology , Vol. 17 2016, Nr. 5, pp. 593 – 603
  • Khairnar, Vishal; Duhan, Vikas; Kumar Maney, Sathish; Seifert, Marc; Kirschning, Carsten; Westendorf, Astrid M.; Dittmer, Ulf; Küppers, Ralf; Scheffrahn, Inka; Göthert, Joachim R.; Singer, Bernhard B.; Lang, Karl S.; et al.
    CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production
    In: Nature Communications , Vol. 6 2015, 6217
  • Lang, Elisabeth; Gatidis, Sergios; Freise, Noemi F; Bock, Hans; Kubitz, Ralf; Lauermann, Christian; Orth, Hans Martin; Klindt, Caroline; Schuier, Maximilian; Keitel, Verena; Reich, Maria; Liu, Guilai; Schmidt, Sebastian; Xu, Haifeng C; Qadri, Syed M; Herebian, Diran; Pandyra, Aleksandra A; Mayatepek, Ertan; Gulbins, Erich; Lang, Florian; Häussinger, Dieter; Lang, Karl S.; Föller, Michael; Lang, Philipp A
    Conjugated Bilirubin Triggers Anemia by Inducing Erythrocyte Death
    In: Hepatology , Vol. 61 2015, Nr. 1, pp. 275 – 284
  • Pandyra, Aleksandra; Mullen, Peter J.; Kalkat, Manpreet; Yu, Rosemary; Pong, Janice T.; Li, Zhihua; Trudel, Suzanne; Lang, Karl S.; Minden, Marc D.; Schimmer, Aaron D.; Penn, Linda Z.
    Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop
    In: Cancer Research , Vol. 74 2014, Nr. 17, pp. 4772 – 4782
  • Nguyen, X. H.; Fattakhova, G.; Lang, P. A.; Lang, Karl S.; Adam, D.; Föger, N.; Lee, K. H.
    Antiapoptotic function of Toso (Faim3) in death receptor signaling
    In: Blood , Vol. 119 2012, Nr. 7, pp. 1790 – 1791
  • Recher, Mike; Burns, Siobhan O.; De La Fuente, Miguel A.; Volpi, Stefano; Dahlberg, Carin; Walter, Jolan E.; Moffitt, Kristin; Mathew, Divij; Honke, Nadine; Lang, Philipp A.; Patrizi, Laura; Falet, Hervé; Keszei, Marton; Mizui, Masayuki; Csizmadia, Eva; Candotti, Fabio; Nadeau, Kari; Bouma, Gerben; Delmonte, Ottavia M.; Frugoni, Francesco; Ferraz Fomin, Angela B.; Buchbinder, David; Lundequist, Emma Maria; Massaad, Michel J.; Tsokos, George C.; Hartwig, John; Manis, John; Terhorst, Cox; Geha, Raif S.; Snapper, Scott; Lang, Karl S.; Malley, Richard; Westerberg, Lisa; Thrasher, Adrian J.; Notarangelo, Luigi D.
    B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice
    In: Blood , Vol. 119 2012, Nr. 12, pp. 2819 – 2828
  • Honke, Nadine; Shaabani, Namir; Cadeddu, Giuseppe; Sorg, Ursula R.; Zhang, Dong-Er; Trilling, Mirko; Klingel, Karin; Sauter, Martina; Kandolf, Reinhard; Gailus, Nicole; Van Rooijen, Nico; Burkart, Christoph; Baldus, Stephan E.; Grusdat, Melanie; Löhning, Max; Hengel, Hartmut; Pfeffer, Klaus; Tanaka, Masato; Häussinger, Dieter; Recher, Mike; Lang, Philipp A.; Lang, Karl S.
    Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus
    In: Nature Immunology , Vol. 13 2012, Nr. 1, pp. 51 – 57
  • McIlwain, David R.; Lang, Philipp A.; Maretzky, Thorsten; Hamada, Koichi; Ohishi, Kazuhito; Maney, Sathish Kumar; Berger, Thorsten; Murthy, Aditya; Duncan, Gordon; Xu, Haifeng C.; Lang, Karl S.; Häussinger, Dieter; Wakeham, Andrew; Itie-Youten, Annick; Khokha, Rama; Ohashi, Pamela S.; Blobel, Carl P.; Mak, Tak W.
    iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS
    In: Science , Vol. 335 2012, Nr. 6065, pp. 229 – 232
  • Pellegrini, M.; Calzascia, T.; Toe, J. G.; Preston, S. P.; Lin, A. E.; Elford, A. R.; Shahinian, A.; Lang, P. A.; Lang, Karl S.; Morre, M.; Assouline, B.; Lahl, K.; Sparwasser, T.; Tedder, T. F.; Paik, J. H.; DePinho, R. A.; Basta, S.; Ohashi, P. S.; Mak, T. W.
    IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology
    In: Cell , Vol. 144 2011, Nr. 4, pp. 601 – 613
  • Nguyen, X. H.; Lang, P. A.; Lang, Karl S.; Adam, D.; Fattakhova, G.; Föger, N.; Kamal, M. A.; Prilla, P.; Mathieu, S.; Wagner, C.; Mak, T.; Chan, A. C.; Lee, K. H.
    Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination
    In: Blood , Vol. 118 2011, Nr. 3, pp. 598 – 608