ZMB Member Karl Sebastian Lang
ZMB Member
Karl Sebastian Lang
Next ZMB-Member
Prof. Dr. Karl Sebastian Lang
Director of:
Institute of Immunology
University Hospital Essen
Hufelandstr. 55
45122 Essen
- +49 201 723 4273
- Website
- Selected Publications
- Publication Metrics
-
- ZMB Research Program
Immunology, Infectious Diseases and Transplantation
Research Overview
The group of Prof. Lang studies molecular and cellular immunological mechanisms which can influence the outcome of human disease. This includes immunopathology occurring during autoimmune disease, infectious disease, tumor disease and transplantation. Mainly immunological models are used for these studies.
The following models are currently used:
- Lmphocytic choriomeningitis virus (LCMV)
- Vesicular stomatitis Virus (VSV)
- Listeria monocytogenes
- RIP-GP model (Autoimmune diabetes)
- B16 melanoma model
Selected Publications
-
Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injuryIn: Gut Vol. 69 (2020) Nr. 1, pp. 133 - 145
ISSN: 1468-3288; 0017-5749Online Full Text: dx.doi.org/ (Open Access) -
Publisher Correction: Tumor-necrosis factor impairs CD4⁺ T cell–mediated immunological control in chronic viral infectionIn: Nature Immunology Vol. 21 (2020) Nr. 9, pp. 1135
ISSN: 1529-2916; 1529-2908Online Full Text: dx.doi.org/ -
Reply [Letter to the Editor: Characterization of CD169+ Macrophages in Liver Regeneration: Tissue Distribution and Fate?]In: Hepatology Vol. 70 (2019) Nr. 3, pp. 1074 - 1075
ISSN: 0270-9139; 1527-3350Online Full Text: dx.doi.org/ -
B Cell-Mediated Maintenance of Cluster of Differentiation 169–Positive Cells Is Critical for Liver RegenerationIn: Hepatology Vol. 68 (2018) Nr. 6, pp. 2348 - 2361
ISSN: 1527-3350; 0270-9139Online Full Text: dx.doi.org/ (Open Access) -
CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infectionIn: Nature Communications Vol. 9 (2018) pp. 2561
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Spatiotemporally restricted arenavirus replication induces immune surveillance and type i interferon-dependent tumour regressionIn: Nature Communications Vol. 8 (2017) pp. 14447
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infectionIn: Nature Immunology Vol. 17 (2016) Nr. 5, pp. 593 - 603
ISSN: 1529-2908Online Full Text: dx.doi.org/ -
CEACAM1 induces B-cell survival and is essential for protective antiviral antibody productionIn: Nature Communications (2015) Nr. 6, pp. 6217
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Conjugated Bilirubin Triggers Anemia by Inducing Erythrocyte DeathIn: Hepatology Vol. 61 (2015) Nr. 1, pp. 275 - 284
ISSN: 0270-9139; 1527-3350Online Full Text: dx.doi.org/ (Open Access) -
Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loopIn: Cancer Research Vol. 74 (2014) Nr. 17, pp. 4772 - 4782
ISSN: 1538-7445Online Full Text: dx.doi.org/ -
Antiapoptotic function of Toso (Faim3) in death receptor signalingIn: Blood Vol. 119 (2012) Nr. 7, pp. 1790 - 1791
ISSN: 0006-4971; 1528-0020Online Full Text: dx.doi.org/ -
B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in miceIn: Blood Vol. 119 (2012) Nr. 12, pp. 2819 - 2828
ISSN: 1528-0020Online Full Text: dx.doi.org/ -
Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virusIn: Nature Immunology Vol. 13 (2012) Nr. 1, pp. 51 - 57
ISSN: 1529-2916Online Full Text: dx.doi.org/ -
iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPSIn: Science Vol. 335 (2012) Nr. 6065, pp. 229 - 232
ISSN: 1095-9203; 0036-8075Online Full Text: dx.doi.org/ -
IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathologyIn: Cell Vol. 144 (2011) Nr. 4, pp. 601 - 613
ISSN: 0092-8674Online Full Text: dx.doi.org/ (Open Access) -
Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitinationIn: Blood Vol. 118 (2011) Nr. 3, pp. 598 - 608
ISSN: 0006-4971; 1528-0020Online Full Text: dx.doi.org/