ZMB Member Karl Sebastian Lang

ZMB Member
Karl Sebastian Lang

Next ZMB-Member
portrait photo of ZMB member Karl Sebastian Lang
© Lang

Prof. Dr. Karl Sebastian Lang

University Hospital Essen
Hufelandstr. 55
45122 Essen

Research Overview

The group of Prof. Lang studies molecular and cellular immunological mechanisms which can influence the outcome of human disease. This includes immunopathology occurring during autoimmune disease, infectious disease, tumor disease and transplantation. Mainly immunological models are used for these studies.

The following models are currently used:

  • Lmphocytic choriomeningitis virus (LCMV)
  • Vesicular stomatitis Virus (VSV)
  • Listeria monocytogenes
  • RIP-GP model (Autoimmune diabetes)
  • B16 melanoma model
Read more

Selected Publications

    Journal articles

  • Zhuang, Yuan; Xu, Haifeng C.; Shinde, Prashant V.; Warfsmann, Jens; Vasilevska, Jelena; Sundaram, Balamurugan; Behnke, Kristina; Huang, Jun; Hoell, Jessica I.; Borkhardt, Arndt; Pfeffer, Klaus; Taha, Mohamed S.; Herebian, Diran; Mayatepek, Ertan; Brenner, Dirk; Ahmadian, Mohammad Reza; Keitel, Verena; Wieczorek, Dagmar; Häussinger, Dieter; Pandyra, Aleksandra A.; Lang, Karl S.; Lang, Philipp A.
    Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury
    In: Gut Vol. 69 (2020) Nr. 1, pp. 133 - 145
    ISSN: 1468-3288; 0017-5749
  • Beyer, Marc; Abdullah, Zeinab; Chemnitz, Jens M.; Maisel, Daniela; Sander, Jil; Lehmann, Clara; Thabet, Yasser; Shinde, Prashant V.; Schmidleithner, Lisa; Köhne, Maren; Trebicka, Jonel; Schierwagen, Robert; Hofmann, Andrea; Popov, Alexey; Lang, Karl S.; Oxenius, Annette; Buch, Thorsten; Kurts, Christian; Heikenwalder, Mathias; Fätkenheuer, Gerd; Lang, Philipp A.; Hartmann, Pia; Knolle, Percy A.; Schultze, Joachim L.
    Publisher Correction: Tumor-necrosis factor impairs CD4⁺ T cell–mediated immunological control in chronic viral infection
    In: Nature Immunology Vol. 21 (2020) Nr. 9, pp. 1135
    ISSN: 1529-2916; 1529-2908
  • Behnke, Kristina; Zhuang, Yuan; Xu, Haifeng C.; Sundaram, Balamurugan; Reich, Maria; Shinde, Prashant V.; Huang, Jun; Modares, Nastaran Fazel; Tumanov, Alexei V.; Polz, Robin; Scheller, Jürgen; Ware, Carl F.; Pfeffer, Klaus; Keitel, Verena; Häussinger, Dieter; Pandyra, Aleksandra A.; Lang, Karl S.; Lang, Philipp A.
    Reply [Letter to the Editor: Characterization of CD169+ Macrophages in Liver Regeneration: Tissue Distribution and Fate?]
    In: Hepatology Vol. 70 (2019) Nr. 3, pp. 1074 - 1075
    ISSN: 0270-9139; 1527-3350
  • Behnke, Kristina; Zhuang, Yuan; Xu, Haifeng C.; Sundaram, Balamurugan; Reich, Maria; Shinde, Prashant V.; Huang, Jun; Modares, Nastaran Fazel; Tumanov, Alexei V.; Polz, Robin; Scheller, Jürgen; Ware, Carl F.; Pfeffer, Klaus; Keitel, Verena; Häussinger, Dieter; Pandyra, Aleksandra A.; Lang, Karl S.; Lang, Philipp A.
    B Cell-Mediated Maintenance of Cluster of Differentiation 169–Positive Cells Is Critical for Liver Regeneration
    In: Hepatology Vol. 68 (2018) Nr. 6, pp. 2348 - 2361
    ISSN: 1527-3350; 0270-9139
  • Khairnar, Vishal; Duhan, Vikas; Patil, Ashwini M.; Zhou, Fan; Bhat, Hilal; Thoens, Christine; Sharma, Piyush; Adomati, Tom; Friendrich, Sarah-Kim; Bezgovsek, Judith; Dreesen, Janine D.; Wennemuth, Gunther; Westendorf, Astrid; Zelinskyy, Gennadiy; Dittmer, Ulf; Hardt, Cornelia; Timm, Jörg; Göthert, Joachim Rudolf; Lang, Philipp A.; Singer, Bernhard B.; Lang, Karl S.
    CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infection
    In: Nature Communications Vol. 9 (2018) pp. 2561
    ISSN: 2041-1723
  • Kalkavan, Halime; Sharma, Piyush; Kasper, Stefan; Helfrich, Iris; Pandyra, Aleksandra A.; Gassa, Asmae; Virchow, Isabel; Flatz, Lukas; Brandenburg, Tim; Namineni, Sukumar; Heikenwalder, Mathias; Höchst, Bastian; Knolle, Percy A.; Wollmann, Guido; Von Laer, Dorothee; Drexler, Ingo; Rathbun, Jessica; Cannon, Paula M.; Scheu, Stefanie; Bauer, Jens; Chauhan, Jagat; Häussinger, Dieter; Willimsky, Gerald; Löhning, Max; Schadendorf, Dirk; Brandau, Sven; Schuler, Martin; Lang, Philipp A.; Lang, Karl S.
    Spatiotemporally restricted arenavirus replication induces immune surveillance and type i interferon-dependent tumour regression
    In: Nature Communications Vol. 8 (2017) pp. 14447
    ISSN: 2041-1723
  • Beyer, Marc; Abdullah, Zeinab; Chemnitz, Jens M; Maisel, Daniela; Sander, Jil; Lehmann, Clara; Thabet, Yasser; Shinde, Prashant V; Schmidleithner, Lisa; Köhne, Maren; Trebicka, Jonel; Schierwagen, Robert; Hofmann, Andrea; Popov, Alexey; Lang, Karl S.; Oxenius, Annette; Buch, Thorsten; Kurts, Christian; Heikenwalder, Mathias; Fätkenheuer, Gerd; Lang, Philipp A; Hartmann, Pia; Knolle, Percy A; Schultze, Joachim L
    Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection
    In: Nature Immunology Vol. 17 (2016) Nr. 5, pp. 593 - 603
    ISSN: 1529-2908
  • Khairnar, Vishal; Duhan, Vikas; Lang, Karl S.
    CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production
    In: Nature Communications (2015) Nr. 6, pp. 6217
    ISSN: 2041-1723
  • Lang, Elisabeth; Gatidis, Sergios; Freise, Noemi F; Bock, Hans; Kubitz, Ralf; Lauermann, Christian; Orth, Hans Martin; Klindt, Caroline; Schuier, Maximilian; Keitel, Verena; Reich, Maria; Liu, Guilai; Schmidt, Sebastian; Xu, Haifeng C; Qadri, Syed M; Herebian, Diran; Pandyra, Aleksandra A; Mayatepek, Ertan; Gulbins, Erich; Lang, Florian; Häussinger, Dieter; Lang, Karl S.; Föller, Michael; Lang, Philipp A
    Conjugated Bilirubin Triggers Anemia by Inducing Erythrocyte Death
    In: Hepatology Vol. 61 (2015) Nr. 1, pp. 275 - 284
    ISSN: 0270-9139; 1527-3350
  • Pandyra, Aleksandra; Mullen, Peter J.; Kalkat, Manpreet; Yu, Rosemary; Pong, Janice T.; Li, Zhihua; Trudel, Suzanne; Lang, Karl S.; Minden, Marc D.; Schimmer, Aaron D.; Penn, Linda
    Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop
    In: Cancer Research Vol. 74 (2014) Nr. 17, pp. 4772 - 4782
    ISSN: 1538-7445
  • Nguyen, X. H.; Fattakhova, G.; Lang, P. A.; Lang, Karl S.; Adam, D.; Föger, N.; Lee, K. H.
    Antiapoptotic function of Toso (Faim3) in death receptor signaling
    In: Blood Vol. 119 (2012) Nr. 7, pp. 1790 - 1791
    ISSN: 0006-4971; 1528-0020
  • Recher, Mike; Burns, Siobhan O.; De La Fuente, Miguel A.; Volpi, Stefano; Dahlberg, Carin; Walter, Jolan E.; Moffitt, Kristin; Mathew, Divij; Honke, Nadine; Lang, Philipp A.; Patrizi, Laura; Falet, Hervé; Keszei, Marton; Mizui, Masayuki; Csizmadia, Eva; Candotti, Fabio; Nadeau, Kari; Bouma, Gerben; Delmonte, Ottavia M.; Frugoni, Francesco; Ferraz Fomin, Angela B.; Buchbinder, David; Lundequist, Emma Maria; Massaad, Michel J.; Tsokos, George C.; Hartwig, John; Manis, John; Terhorst, Cox; Geha, Raif S.; Snapper, Scott; Lang, Karl S.; Malley, Richard; Westerberg, Lisa; Thrasher, Adrian J.; Notarangelo, Luigi D.
    B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice
    In: Blood Vol. 119 (2012) Nr. 12, pp. 2819 - 2828
    ISSN: 1528-0020
  • Honke, Nadine; Shaabani, Namir; Cadeddu, Giuseppe; Sorg, Ursula R.; Zhang, Dong-Er; Trilling, Mirko; Klingel, Karin; Sauter, Martina; Kandolf, Reinhard; Gailus, Nicole; Van Rooijen, Nico; Burkart, Christoph; Baldus, Stephan E.; Grusdat, Melanie; Löhning, Max; Hengel, Hartmut; Pfeffer, Klaus; Tanaka, Masato; Häussinger, Dieter; Recher, Mike; Lang, Philipp A.; Lang, Karl S.
    Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus
    In: Nature Immunology Vol. 13 (2012) Nr. 1, pp. 51 - 57
    ISSN: 1529-2916
  • McIlwain, David R.; Lang, Philipp A.; Maretzky, Thorsten; Hamada, Koichi; Ohishi, Kazuhito; Maney, Sathish Kumar; Berger, Thorsten; Murthy, Aditya; Duncan, Gordon; Xu, Haifeng C.; Lang, Karl S.; Häussinger, Dieter; Wakeham, Andrew; Itie-Youten, Annick; Khokha, Rama; Ohashi, Pamela S.; Blobel, Carl P.; Mak, Tak W.
    iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS
    In: Science Vol. 335 (2012) Nr. 6065, pp. 229 - 232
    ISSN: 1095-9203; 0036-8075
  • Pellegrini, M.; Calzascia, T.; Toe, J. G.; Preston, S. P.; Lin, A. E.; Elford, A. R.; Shahinian, A.; Lang, P. A.; Lang, Karl S.; Morre, M.; Assouline, B.; Lahl, K.; Sparwasser, T.; Tedder, T. F.; Paik, J. H.; DePinho, R. A.; Basta, S.; Ohashi, P. S.; Mak, T. W.
    IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology
    In: Cell Vol. 144 (2011) Nr. 4, pp. 601 - 613
    ISSN: 0092-8674
  • Nguyen, X. H.; Lang, P. A.; Lang, Karl S.; Adam, D.; Fattakhova, G.; Föger, N.; Kamal, M. A.; Prilla, P.; Mathieu, S.; Wagner, C.; Mak, T.; Chan, A. C.; Lee, K. H.
    Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination
    In: Blood Vol. 118 (2011) Nr. 3, pp. 598 - 608
    ISSN: 0006-4971; 1528-0020