ZMB Member Karl Sebastian Lang
ZMB Member
Karl Sebastian Lang
Next ZMB-Member
Prof. Dr. Karl Sebastian Lang
Director of:
Institute of Immunology
University Hospital Essen
Hufelandstr. 55
45122 Essen
- +49 201 723 4273
- Website
- Selected Publications
- Publication Metrics
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- ZMB Research Program
Immunology, Infectious Diseases and Transplantation
Research Overview
The group of Prof. Lang studies molecular and cellular immunological mechanisms which can influence the outcome of human disease. This includes immunopathology occurring during autoimmune disease, infectious disease, tumor disease and transplantation. Mainly immunological models are used for these studies.
The following models are currently used:
- Lmphocytic choriomeningitis virus (LCMV)
- Vesicular stomatitis Virus (VSV)
- Listeria monocytogenes
- RIP-GP model (Autoimmune diabetes)
- B16 melanoma model
Selected Publications
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CEACAM1 as a mediator of B-cell receptor signaling in mantle cell lymphomaIn: Nature Communications , Vol. 16 2025, Nr. 1, 4967DOI (Open Access)
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BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor MicroenvironmentIn: Cancer Research , Vol. 82 2022, Nr. 2, pp. 264 – 277DOI (Open Access)
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Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expressionIn: Nature Communications , Vol. 13 2022, Nr. 1, 156DOI (Open Access)
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Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to ImmunotherapiesIn: Cancer Research , Vol. 81 2021, Nr. 21, pp. 5540 – 5554DOI (Open Access)
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A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus controlIn: Journal of Hepatology , Vol. 72 2020, Nr. 5, pp. 960 – 975DOI (Open Access)
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Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe diseaseIn: Nature Communications , Vol. 11 2020, Nr. 1, pp. 1338DOI, Online Full Text (Open Access)
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Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injuryIn: Gut , Vol. 69 2020, Nr. 1, pp. 133 – 145DOI (Open Access)
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Publisher Correction: Tumor-necrosis factor impairs CD4⁺ T cell–mediated immunological control in chronic viral infectionIn: Nature Immunology , Vol. 21 2020, Nr. 9, pp. 1135DOI (Open Access)
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Reply [Letter to the Editor: Characterization of CD169+ Macrophages in Liver Regeneration: Tissue Distribution and Fate?]In: Hepatology , Vol. 70 2019, Nr. 3, pp. 1074 – 1075DOI (Open Access)
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B Cell-Mediated Maintenance of Cluster of Differentiation 169–Positive Cells Is Critical for Liver RegenerationIn: Hepatology , Vol. 68 2018, Nr. 6, pp. 2348 – 2361DOI (Open Access)
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CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infectionIn: Nature Communications , Vol. 9 2018, 2561DOI (Open Access)
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Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in miceIn: Hepatology , Vol. 68 2018, Nr. 1, pp. 200 – 214
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Spatiotemporally restricted arenavirus replication induces immune surveillance and type i interferon-dependent tumour regressionIn: Nature Communications , Vol. 8 2017, pp. 14447DOI (Open Access)
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Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infectionIn: Nature Immunology , Vol. 17 2016, Nr. 5, pp. 593 – 603
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CEACAM1 induces B-cell survival and is essential for protective antiviral antibody productionIn: Nature Communications , Vol. 6 2015, 6217DOI (Open Access)
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Conjugated Bilirubin Triggers Anemia by Inducing Erythrocyte DeathIn: Hepatology , Vol. 61 2015, Nr. 1, pp. 275 – 284DOI (Open Access)
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Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loopIn: Cancer Research , Vol. 74 2014, Nr. 17, pp. 4772 – 4782
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Antiapoptotic function of Toso (Faim3) in death receptor signalingIn: Blood , Vol. 119 2012, Nr. 7, pp. 1790 – 1791
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B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in miceIn: Blood , Vol. 119 2012, Nr. 12, pp. 2819 – 2828
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Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virusIn: Nature Immunology , Vol. 13 2012, Nr. 1, pp. 51 – 57
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iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPSIn: Science , Vol. 335 2012, Nr. 6065, pp. 229 – 232
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IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathologyIn: Cell , Vol. 144 2011, Nr. 4, pp. 601 – 613DOI (Open Access)
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Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitinationIn: Blood , Vol. 118 2011, Nr. 3, pp. 598 – 608