ZMB Member Elisabeth Littwitz-Salomon

ZMB Member
Elisabeth Littwitz-Salomon

Next Member
Elisabeth Littwitz-Salomon
© E. Littwitz-Salomon

Jun.-Prof. Dr. Elisabeth Littwitz-Salomon

Group

Immune Metabolism in Infection and Cancer

Institute for The Research on HIV and AIDS-associated Diseases
University Hospital Essen
Robert Koch Haus 179
45147 Essen

Research Overview

Despite intensive research, the cure of infections with retroviruses, e.g. the immunodeficiency virus (HIV), is still impossible with the strategies currently used. New ways of strengthening the body's own immunity and improving antiviral functions are therefore of outstanding interest. Natural killer (NK) cells are an important cell type of innate immunity that fights infection until adaptive immunity takes over. For their activity, NK cells undergo metabolic reprogramming to meet their increased demand for nutrients and energy. We have shown that metabolism plays an essential role in the cytotoxic function of antiviral NK cells.

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Publications

    Journal articles

  • Schimmer, Simone; Kerkmann, Leonie; Kahlert, Nele; al Jubeh, Shahd; Werner, Tanja; Corkish, Carrie; Prendeville, Hannah; Finlay, David K.; Sutter, Kathrin; Dittmer, Ulf; Littwitz-Salomon, Elisabeth
    Dietary lipid overload creates a suppressive environment that impedes the antiviral functions of NK cells
    In: iScience, Vol. 28, 2025, Nr. 5, 112396
    DOI (Open Access)
  • Schimmer, Simone; Sridhar, Vaasudevan; Satan, Zelal; Grebe, Anton; Saad, Mohamed; Wagner, Bernd; Kahlert, Nele; Werner, Tanja; Richter, Dana; Dittmer, Ulf; Sutter, Kathrin; Littwitz-Salomon, Elisabeth
    Iron improves the antiviral activity of NK cells
    In: Frontiers in Immunology, Vol. 15, 2025, 1526197
    DOI, Online Full Text (Open Access)
  • Mittermüller, Daniela; Otto, Lucas; Kilian, Annika Loredana; Schnormeier, Ann-Kathrin; Littwitz-Salomon, Elisabeth; Hasenberg, Anja; Dittmer, Ulf; Gunzer, Matthias
    PD-1 knockout on cytotoxic primary murine CD8+ T cells improves their motility in retrovirus infected mice
    In: Frontiers in Immunology, Vol. 15, 2024, 1338218
    DOI, Online Full Text (Open Access)
  • Picard, Lea Katharina; Niemann, Jens Alexander; Littwitz-Salomon, Elisabeth; Waldmann, Herbert; Watzl, Carsten
    Restriction of Glycolysis Increases Serial Killing Capacity of Natural Killer Cells
    In: International Journal of Molecular Sciences (IJMS), Vol. 25, 2024, Nr. 5, 2917
    DOI (Open Access)
  • Schimmer, Simone; Mittermüller, Daniela; Werner, Tanja; Görs, Paul E.; Meckelmann, Sven; Finlay, David K.; Dittmer, Ulf; Littwitz-Salomon, Elisabeth
    Fatty acids are crucial to fuel NK cells upon acute retrovirus infection
    In: Frontiers in Immunology, Vol. 14, 2023, 1296355
    DOI, Online Full Text (Open Access)
  • Schild, Yves; Bosserhoff, Jonah; Droege, Freya; Littwitz-Salomon, Elisabeth; Fandrey, Joachim; Wrobeln, Anna
    Hypoxia-Inducible Factor–Prolyl Hydroxylase Inhibitor Improves Leukocyte Energy Metabolism in Hereditary Hemorrhagic Telangiectasia
    In: Life, Vol. 13, 2023, Nr. 8, 1708
    DOI, Online Full Text (Open Access)
  • Picard, Lea Katharina; Littwitz-Salomon, Elisabeth; Waldmann, Herbert; Watzl, Carsten
    Inhibition of Glucose Uptake Blocks Proliferation but Not Cytotoxic Activity of NK Cells
    In: Cells, Vol. 11, 2022, Nr. 21, 3489
    DOI (Open Access)
  • Schmitz, Yasmin; Schwerdtfeger, Mara; Westmeier, Jaana; Littwitz-Salomon, Elisabeth; Alt, Mira; Brochhagen, Leonie; Krawczyk, Adalbert; Sutter, Kathrin
    Superior antiviral activity of IFNβ in genital HSV-1 infection
    In: Frontiers in Cellular and Infection Microbiology, Vol. 12, 2022, 949036
    DOI, Online Full Text (Open Access)
  • Littwitz-Salomon, Elisabeth; Moreira, Diana; Frost, Joe N.; Choi, Chloe; Liou, Kevin T.; Ahern, David K.; O’Shaughnessy, Simon; Wagner, Bernd; Biron, Christine A.; Drakesmith, Hal; Dittmer, Ulf; Finlay, David K.
    Metabolic requirements of NK cells during the acute response against retroviral infection
    In: Nature Communications, Vol. 12, 2021, Nr. 1, 5376
    DOI, Online Full Text (Open Access)
  • Zou, Shi; Du, Yanqin; Huang, Shunmei; Chen, Mingfa; Yang, Xiaoli; Li, Sumeng; Chen, Yingshan; Han, Meihong; Li, Jia; Yu, Qing; Littwitz-Salomon, Elisabeth; Huang, Hongming; Trilling, Mirko; Liu, Shi; Pei, Rongjuan; Liu, Jia; Wang, Baoju; Zheng, Xin; Lu, Mengji; Dittmer, Ulf; Sun, Shuilin; Yang, Dongliang; Wu, Jun
    Simultaneous or Prior Activation of Intrahepatic Type I Interferon Signaling Leads to Hepatitis B Virus Persistence in a Mouse Model
    In: Journal of Virology, Vol. 95, 2021, Nr. 24, e00034-21
    DOI, Online Full Text (Open Access)
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Sutter, Kathrin; Ross, Jean Alexander; Paschen, Annette; Windmann, Sonja; Schimmer, Simone; Dittmer, Ulf
    Chronic retroviral infection of mice promotes tumor development, but CD137 agonist therapy restores effective tumor immune surveillance
    In: Cancer Immunology, Immunotherapy, Vol. 68, 2019, Nr. 3, pp. 479 – 488
    DOI, Online Full Text (Open Access)
  • Moore, Tyler C.; Messer, Ronald J.; Gonzaga, Lorena M.; Mather, Jennifer M.; Carmody, Aaron B.; Bayer, Wibke; Littwitz-Salomon, Elisabeth; Dittmer, Ulf; Hasenkrug, Kim J.
    Effects of Friend Virus Infection and Regulatory T Cells on the Antigen Presentation Function of B Cells
    In: mBio, Vol. 10, 2019, Nr. 1, pp. e02578 – 18
    DOI (Open Access)
  • Hotter, Dominik; Bosso, Matteo; Jønsson, Kasper L.; Krapp, Christian; Stürzel, Christina M.; Das, Atze; Littwitz-Salomon, Elisabeth; Berkhout, Ben; Russ, Alina; Wittmann, Sabine; Gramberg, Thomas; Zheng, Yue; Martins, Laura J.; Planelles, Vicente; Jakobsen, Martin R.; Hahn, Beatrice H.; Dittmer, Ulf; Sauter, Daniel; Kirchhoff, Frank
    IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation
    In: Cell Host & Microbe, Vol. 25, 2019, Nr. 6, pp. 858 – 872.e13
    DOI (Open Access)
  • Kedia-Mehta, Nidhi; Choi, Chloe; McCrudden, Aisling; Littwitz-Salomon, Elisabeth; Fox, Proinnsias G.; Gardiner, Clair M.; Finlay, David K.
    Natural Killer Cells Integrate Signals Received from Tumour Interactions and IL2 to Induce Robust and Prolonged Anti-Tumour and Metabolic Responses
    In: Immunometabolism, Vol. 1, 2019, pp. e190014
    DOI, Online Full Text (Open Access)
  • Littwitz-Salomon, Elisabeth; Nguyen, Thanh; Schimmer, Simone; Dittmer, Ulf
    Friend retrovirus infection induces the development of memory-like natural killer cells 11 Medical and Health Sciences 1107 Immunology
    In: Retrovirology, Vol. 15, 2018, Nr. 1, 68
    DOI (Open Access)
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Dittmer, Ulf; Schimmer, Simone
    The Cytotoxic Activity of Natural Killer Cells Is Suppressed by IL-10⁺ Regulatory T Cells During Acute Retroviral Infection
    In: Frontiers in Immunology, Vol. 9, 2018, pp. 1947
    DOI (Open Access)
  • Littwitz-Salomon, Elisabeth; Schimmer, Simone; Dittmer, Ulf
    Dose of retroviral infection determines induction of antiviral NK cell responses
    In: Journal of Virology, Vol. 91, 2017, Nr. 22, pp. e01122 – 17
    DOI (Open Access)
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Sutter, Kathrin; Zelinskyy, Gennadiy; Windmann, Sonja; Schimmer, Simone; Paschen, Annette; Streeck, Hendrik; Hasenkrug, Kim J; Dittmer, Ulf
    Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection
    In: Scientific Reports, Vol. 7, 2017, pp. 7785
    DOI (Open Access)
  • Littwitz-Salomon, Elisabeth; Schimmer, Simone; Dittmer, Ulf
    Natural killer T cells contribute to the control of acute retroviral infection
    In: Retrovirology, Vol. 14, 2017, Nr. 1, 5
    DOI, Online Full Text (Open Access)
  • Akhmetzyanova, Ilseyar; Dittmer, Ulf; Brandau, Sven; Streeck, Hendrik; Dietze, Kirsten; Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Zelinskyy, Gennadiy
    CD137 agonist therapy can reprogram regulatory T cells into cytotoxic CD4+ T cells with antitumor activity
    In: The Journal of Immunology (JI), Vol. 196, 2016, Nr. 1, pp. 484 – 492
    DOI (Open Access)
  • Littwitz-Salomon, Elisabeth; Dittmer, Ulf; Sutter, Kathrin
    Insufficient natural killer cell responses against retroviruses : How to improve NK cell killing of retrovirus-infected cells
    In: Retrovirology, Vol. 13, 2016, Nr. 1, 77
    DOI (Open Access)
  • Littwitz-Salomon, Elisabeth; Akhmetzyanova, Ilseyar; Vallet, Cecilia; Francois, Sandra; Dittmer, Ulf; Gibbert, Kathrin
    Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection
    In: Retrovirology, Vol. 12, 2015, Nr. 1, 66
    DOI (Open Access)
  • Littwitz-Salomon, Elisabeth; Francois, Sandra; Dittmer, Ulf; Gibbert, Kathrin
    Distinct roles of NK cells in viral immunity during different phases of acute Friend retrovirus infection
    In: Retrovirology, Vol. 10, 2013, Nr. 1, 127
    DOI (Open Access)
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