ZMB Member Dietmar Lohmann

ZMB Member
Dietmar Lohmann

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Dietmar Lohmann portrait
© D.Lohmann

Prof. Dr. Dietmar Lohmann

Group

Ophthalmic Oncology and Genetics

Institute of Human Genetics
University Hospital Essen
Hufelandstr. 55
45122 Essen

Research Overview

Retinoblastoma

  • Determining the genetic architecture underlying predisposition to retinoblastoma
  • Identification of risk factors for development of extraocular neoplasms in patients with retinoblastoma
  • Analysis of changes of the genetic landscape during retinoblastoma progression

 

Uveal Melanoma

  • Identification of heritable genetic alterations that alter the risk for uveal melanoma
  • Development of prognostic and predictive biomarkers
  • Determining somatic genetic alterations linked to metastasizing uveal melanoma

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Selected Publications

    Journal articles

  • Grümme, Lea; Biewald, Eva; Reschke, Madlen; Fischhuber, Karen; Hanbücken, Anna; Schlüter, Sabrina; Müller, Bert; Kiefer, Tobias; Göricke, Sophia Luise; Geismar, Dirk; Ryl, Tatsiana; Sirin, Selma; Wieland, Regina; Timmermann, Beate; Lohmann, Dietmar; Ebinger, Martin; Brecht, Ines B.; Schönberger, Stefan; Schwab, Christoph; Eggert, Angelika; Süsskind, Daniela; Ritter-Sovinz, Petra; Bechrakis, Nikolaos E.; Ketteler, Petra
    Comparing efficacy and side effects of two systemic chemotherapy regimens for eye-preserving therapy in children with retinoblastoma
    In: Pediatric Blood and Cancer (2021)
    ISSN: 1545-5017; 1545-5009; 1096-911X; 0098-1532
    Online Full Text: dx.doi.org/ (Open Access)
  • Reschke, Madlen; Biewald, Eva; Bronstein, Leo; Brecht, Ines B.; Dittner-Moormann, Sabine; Driever, Frank; Ebinger, Martin; Fleischhack, Gudrun; Grabow, Desiree; Geismar, Dirk; Göricke, Sophia Luise; Guberina, Maja; Le Guin, Claudia; Kiefer, Tobias; Kratz, Christian P.; Metz, Klaus; Müller, Bert; Ryl, Tatsiana; Schlamann, Marc; Schlüter, Sabrina; Schönberger, Stefan; Schulte, Johannes H.; Sirin, Selma; Süsskind, Daniela; Timmermann, Beate; Ting, Saskia; Wackernagel, Werner; Wieland, Regina; Zenker, Martin; Zeschnigk, Michael; Reinhardt, Dirk; Eggert; Ritter-Sovinz, Petra; Lohmann, Dietmar; Bornfeld, Norbert; Bechrakis, Nikolaos; Ketteler, Petra
    Eye tumors in childhood as first sign of tumor predisposition syndromes : Insights from an observational study conducted in Germany and Austria
    In: Cancers Vol. 13 (2021) Nr. 8, pp. 1876
    ISSN: 2072-6694
    Online Full Text: dx.doi.org/ (Open Access)
  • Hülsenbeck, Isabel; Frank, Mirjam; Biewald, Eva; Kanber, Deniz; Lohmann, Dietmar; Ketteler, Petra
    Introduction of a variant classification system for analysis of genotype-phenotype relationships in heritable retinoblastoma
    In: Cancers Vol. 13 (2021) Nr. 7, pp. 1605
    ISSN: 2072-6694
    Online Full Text: dx.doi.org/ (Open Access)
  • Pfaff, Elke; Aichmüller, Christian; Sill, Martin; Stichel, Damian; Snuderl, Matija; Karajannis, Matthias A.; Schuhmann, Martin U.; Schittenhelm, Jens; Hasselblatt, Martin; Thomas, Christian; Korshunov, Andrey; Rhizova, Marina; Wittmann, Andrea; Kaufhold, Anna; Iskar, Murat; Ketteler, Petra; Lohmann, Dietmar; Orr, Brent A.; Ellison, David W.; von Hoff, Katja; Mynarek, Martin; Rutkowski, Stefan; Sahm, Felix; von Deimling, Andreas; Lichter, Peter; Kool, Marcel; Zapatka, Marc; Pfister, Stefan M.; Jones, David T. W.
    Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations
    In: Acta Neuropathologica Vol. 139 (2020) Nr. 2, pp. 243 - 257
    ISSN: 1432-0533; 0001-6322
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Römer, Tristan; Temming, Petra; Lohmann, Dietmar; Sturm, Dominik; von Deimling, Andreas; Sellhaus, Bernd; Mull, Michael; Kontny, Udo; Moser, Olga
    Ectopic intracranial retinoblastoma in a 3.5-month-old infant without eye involvement and without evidence of heritability
    In: Pediatric Blood and Cancer Vol. 66 (2019) Nr. 5, pp. e27599
    ISSN: 1545-5009; 1545-5017
    Online Full Text: dx.doi.org/
  • Le Guin, Claudia Helga Dorothee; Metz, Klaus; Kreis, Stefan Horst; Bechrakis, Nikolaos E.; Bornfeld, Norbert; Zeschnigk, Michael; Lohmann, Dietmar
    GNAQ Q209R Mutations Are Highly Specific for Circumscribed Choroidal Hemangioma
    In: Cancers Vol. 11 (2019) Nr. 7, pp. 1031
    ISSN: 2072-6694
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Hofer, Silvia; Diebold, Joachim; Temming, Petra; Lohmann, Dietmar; Howell, Jeremy; Moulin, Alexandre P.; Beck-Popovic, Maja; Sahm, Felix; Milde, Till; Ecker, Jonas
    Retinoblastoma with late metastatic spread : a case report
    In: Pediatric Blood and Cancer Vol. 66 (2019) Nr. 6, pp. e27656
    ISSN: 1545-5017; 1545-5009
    Online Full Text: dx.doi.org/
  • Gröbner, Susanne N; Worst, Barbara C; Weischenfeldt, Joachim; Buchhalter, Ivo; Kleinheinz, Kortine; Rudneva, Vasilisa A; Johann, Pascal D; Balasubramanian, Gnana Prakash; Segura-Wang, Maia; Brabetz, Sebastian; Bender, Sebastian; Hutter, Barbara; Sturm, Dominik; Pfaff, Elke; Hübschmann, Daniel; Zipprich, Gideon; Heinold, Michael; Eils, Jürgen; Lawerenz, Christian; Erkek, Serap; Lambo, Sander; Waszak, Sebastian; Blattmann, Claudia; Borkhardt, Arndt; Kuhlen, Michaela; Eggert, Angelika; Fulda, Simone; Gessler, Manfred; Wegert, Jenny; Kappler, Roland; Baumhoer, Daniel; Burdach, Stefan; Kirschner-Schwabe, Renate; Kontny, Udo; Kulozik, Andreas E; Lohmann, Dietmar; Hettmer, Simone; Eckert, Cornelia; Bielack, Stefan; Nathrath, Michaela; Niemeyer, Charlotte; Richter, Günther H; Schulte, Johannes; Siebert, Reiner; Westermann, Frank; Molenaar, Jan J; Vassal, Gilles; Witt, Hendrik; Burkhardt, Birgit; Kratz, Christian P; Witt, Olaf; van Tilburg, Cornelis M; Kramm, Christof M; Fleischhack, Gudrun; Dirksen, Uta; Rutkowski, Stefan; Frühwald, Michael; von Hoff, Katja; Wolf, Stephan; Klingebiel, Thomas; Koscielniak, Ewa; Landgraf, Pablo; Koster, Jan; Resnick, Adam C; Zhang, Jinghui; Liu, Yanling; Zhou, Xin; Waanders, Angela J; Zwijnenburg, Danny A; Raman, Pichai; Brors, Benedikt; Weber, Ursula D; Northcott, Paul A; Pajtler, Kristian; Kool, Marcel; Piro, Rosario M; Korbel, Jan O; Schlesner, Matthias; Eils, Roland; Jones, David T W; Lichter, Peter; Chavez, Lukas; Zapatka, Marc; Pfister, Stefan M; ICGC PedBrain-Seq Project; ICGC MMML-Seq Project
    Author Correction : The landscape of genomic alterations across childhood cancers
    In: Nature Vol. 559 (2018) Nr. 7714, pp. E10
    ISSN: 0028-0836; 1476-4687
    Online Full Text: dx.doi.org/ (Open Access)
  • Capper, David; Jones, David T. W.; Sill, Martin; Hovestadt, Volker; Schrimpf, Daniel; Sturm, Dominik; Koelsche, Christian; Sahm, Felix; Chavez, Lukas; Reuss, David E.; Kratz, Annekathrin; Wefers, Annika K.; Huang, Kristin; Pajtler, Kristian; Schweizer, Leonille; Stichel, Damian; Olar, Adriana; Engel, Nils W.; Lindenberg, Kerstin; Harter, Patrick N.; Braczynski, Anne K.; Plate, Karl H.; Dohmen, Hildegard; Garvalov, Boyan K.; Coras, Roland; Hölsken, Annett; Hewer, Ekkehard; Bewerunge-Hudler, Melanie; Schick, Matthias; Fischer, Roger; Beschorner, Rudi; Schittenhelm, Jens; Staszewski, Ori; Wani, Khalida; Varlet, Pascale; Pages, Melanie; Temming, Petra; Lohmann, Dietmar; Selt, Florian; Witt, Hendrik; Milde, Till; Witt, Olaf; Aronica, Eleonora; Giangaspero, Felice; Rushing, Elisabeth; Scheurlen, Wolfram; Geisenberger, Christoph; Rodriguez, Fausto J.; Becker, Albert; Preusser, Matthias; Haberler, Christine; Bjerkvig, Rolf; Cryan, Jane; Farrell, Michael; Deckert, Martina; Hench, Jürgen; Frank, Stephan; Serrano, Jonathan; Kannan, Kasthuri; Tsirigos, Aristotelis; Brück, Wolfgang; Hofer, Silvia; Brehmer, Stefanie; Seiz-Rosenhagen, Marcel; Hänggi, Daniel; Hans, Volkmar; Rozsnoki, Stephanie; Hansford, Jordan R.; Kohlhof, Patricia; Kristensen, Bjarne W.; Lechner, Matt; Lopes, Beatriz; Mawrin, Christian; Ketter, Ralf; Kulozik, Andreas; Khatib, Ziad; Heppner, Frank; Koch, Arend; Jouvet, Anne; Keohane, Catherine; Mühleisen, Helmut; Mueller, Wolf; Pohl, Ute; Prinz, Marco; Benner, Axel; Zapatka, Marc; Gottardo, Nicholas G.; Driever, Pablo Hernáiz; Kramm, Christof M.; Müller, Hermann L.; Rutkowski, Stefan; Von Hoff, Katja; Frühwald, Michael C.; Gnekow, Astrid; Fleischhack, Gudrun; Tippelt, Stephan; Calaminus, Gabriele; Monoranu, Camelia-Maria; Perry, Arie; Jones, Chris; Jacques, Thomas S.; Radlwimmer, Bernhard; Gessi, Marco; Pietsch, Torsten; Schramm, Johannes; Schackert, Gabriele; Westphal, Manfred; Reifenberger, Guido; Wesseling, Pieter; Weller, Michael; Collins, Vincent Peter; Blümcke, Ingmar; Bendszus, Martin; Debus, Jürgen; Huang, Annie; Jabado, Nada; Northcott, Paul A.; Paulus, Werner; Gajjar, Amar; Robinson, Giles W.; Taylor, Michael D.; Jaunmuktane, Zane; Ryzhova, Marina; Platten, Michael; Unterberg, Andreas; Wick, Wolfgang; Karajannis, Matthias A.; Mittelbronn, Michel; Acker, Till; Hartmann, Christian; Aldape, Kenneth; Schüller, Ulrich; Buslei, Rolf; Lichter, Peter; Kool, Marcel; Herold-Mende, Christel; Ellison, David W.; Hasselblatt, Martin; Snuderl, Matija; Brandner, Sebastian; Korshunov, Andrey; Von Deimling, Andreas; Pfister, Stefan M.
    DNA methylation-based classification of central nervous system tumours
    In: Nature Vol. 555 (2018) Nr. 7697, pp. 469 - 474
    ISSN: 0028-0836; 1476-4687
    Online Full Text: dx.doi.org/ (Open Access)
  • Gröbner, Susanne N.; Worst, Barbara C.; Weischenfeldt, Joachim; Buchhalter, Ivo; Kleinheinz, Kortine; Rudneva, Vasilisa A.; Johann, Pascal D.; Balasubramanian, Gnana Prakash; Segura-Wang, Maia; Brabetz, Sebastian; Bender, Sebastian; Hutter, Barbara; Sturm, Dominik; Pfaff, Elke; Hübschmann, Daniel; Zipprich, Gideon; Heinold, Michael; Eils, Jürgen; Lawerenz, Christian; Erkek, Serap; Lambo, Sander; Waszak, Sebastian; Blattmann, Claudia; Borkhardt, Arndt; Kuhlen, Michaela; Eggert, Angelika; Fulda, Simone; Gessler, Manfred; Wegert, Jenny; Kappler, Roland; Baumhoer, Daniel; Burdach, Stefan; Kirschner-Schwabe, Renate; Kontny, Udo; Kulozik, Andreas E.; Lohmann, Dietmar; Hettmer, Simone; Eckert, Cornelia; Bielack, Stefan; Nathrath, Michaela; Niemeyer, Charlotte; Richter, Günther H.; Schulte, Johannes; Siebert, Reiner; Westermann, Frank; Molenaar, Jan J.; Vassal, Gilles; Witt, Hendrik; Zapatka, Marc; Burkhardt, Birgit; Kratz, Christian P.; Witt, Olaf; Tilburg, Cornelis M. Van; Kramm, Christof M.; Fleischhack, Gudrun; Dirksen, Uta; Rutkowski, Stefan; Frühwald, Michael; Hoff, Katja Von; Wolf, Stephan; Klingebiel, Thomas; Koscielniak, Ewa; Landgraf, Pablo; Koster, Jan; Resnick, Adam C.; Zhang, Jinghui; Liu, Yanling; Zhou, Xin; Waanders, Angela J.; Zwijnenburg, Danny A.; Raman, Pichai; Brors, Benedikt; Weber, Ursula D.; Northcott, Paul A.; Pajtler, Kristian; Kool, Marcel; Piro, Rosario M.; Korbel, Jan O.; Schlesner, Matthias; Eils, Roland; Jones, David T. W.; Lichter, Peter; Chavez, Lukas; Pfister, Stefan M.
    The landscape of genomic alterations across childhood cancers
    In: Nature Vol. 555 (2018) Nr. 7696, pp. 321 - 327
    ISSN: 0028-0836; 1476-4687
    Online Full Text: dx.doi.org/ (Open Access)
  • Reschke, M.; Borowski, M.; Johannes, S.; Sovinz-Ritter, P.; Sauerwein, Wolfgang; Goerike, S.; Eggert, Angelika; Bornfeld, Norbert; Lohmann, Dietmar; Temming, P.
    First Prospective National Registry for Pediatric Eye Cancer in Germany and Austria
    In: Pediatric Blood and Cancer Vol. 64 (2017) Nr. Suppl. 3, pp. S276 - S277
    ISSN: 1545-5009; 1545-5017
  • Temming, Petra; Arendt, Marina; Viehmann, Anja; Eisele, Lewin; Le Guin, Claudia H. D.; Schündeln, Michael; Biewald, Eva; Astrahantseff, Kathy; Wieland, Regina; Bornfeld, Norbert; Sauerwein, Wolfgang; Eggert, Angelika; Jöckel, Karl-Heinz; Lohmann, Dietmar
    Incidence of second cancers after radiotherapy and systemic chemotherapy in heritable retinoblastoma survivors : a report from the German reference center
    In: Pediatric Blood and Cancer Vol. 64 (2017) Nr. 1, pp. 71 - 80
    ISSN: 1545-5009; 1545-5017
    Online Full Text: dx.doi.org/
  • Temming, Petra; Arendt, Marina; Viehmann, Anja; Eisele, Lewin; Le Guin, Claudia H D; Schündeln, Michael; Biewald, Eva; Mäusert, Jennifer; Wieland, Regina; Bornfeld, Norbert; Sauerwein, Wolfgang; Eggert, Angelika; Lohmann, Dietmar; Jöckel, Karl-Heinz
    How Eye-Preserving Therapy Affects Long-Term Overall Survival in Heritable Retinoblastoma Survivors
    In: Journal of Clinical Oncology Vol. 34 (2016) Nr. 26, pp. 3183 - 3188
    ISSN: 0732-183X; 1527-7755
    Online Full Text: dx.doi.org/
  • Temming, Petra; Viehmann, Anja; Arendt, Marina; Eisele, Lewin; Spix, Claudia; Bornfeld, Norbert; Sauerwein, Wolfgang; Jöckel, Karl-Heinz; Lohmann, Dietmar
    Pediatric second primary malignancies after retinoblastoma treatment
    In: Pediatric Blood and Cancer Vol. 62 (2015) Nr. 10, pp. 1799 - 1804
    ISSN: 1545-5009; 1545-5017; 0098-1532; 1096-911X
    Online Full Text: dx.doi.org/ (Open Access)
  • Rushlow, Diane E.; Mol, Berber M.; Kennett, Jennifer Y.; Yee, Stephanie; Pajovic, Sanja; Thériault, Brigitte L.; Prigoda-Lee, Nadia L.; Spencer, Clarellen; Dimaras, Helen; Corson, Timothy W.; Pang, Renée; Massey, Christine; Godbout, Roseline; Jiang, Zhe; Zacksenhaus, Eldad; Paton, Katherine; Moll, Annette C.; Houdayer, Claude; Raizis, Anthony; Halliday, William; Lam, Wan L.; Boutros, Paul C.; Lohmann, Dietmar; Dorsman, Josephine C.; Gallie, Brenda L.
    Characterisation of retinoblastomas without RB1 mutations: Genomic, gene expression, and clinical studies
    In: The Lancet Oncology Vol. 14 (2013) Nr. 4, pp. 327 - 334
    ISSN: 1470-2045; 1474-5488
    Online Full Text: dx.doi.org/
  • Martin, Marcel; Maßhöfer, Lars; Temming, Petra; Rahmann, Sven; Metz, Claudia; Bornfeld, Norbert; van de Nes, Johannes; Klein-Hitpaß, Ludger; Hinnebusch, Alan G.; Horsthemke, Bernhard; Lohmann, Dietmar; Zeschnigk, Michael
    Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3
    In: Nature Genetics Vol. 45 (2013) Nr. 8, pp. 933 - 936
    ISSN: 1061-4036; 1546-1718
    Online Full Text: dx.doi.org/
  • Temming, Petra; Bornfeld, Norbert; Lohmann, Dietmar
    Sporadic unilateral retinoblastoma or first sign of bilateral disease?
    In: Pediatric Blood and Cancer Vol. 59 (2012) Nr. 6, pp. 1064 - 1064
    ISSN: 1545-5009; 1545-5017
  • Pall, P.; Aina, T.; Stone, D. A.; Stott, P. A.; Nozawa, T.; Hilberts, A. G.; Lohmann, Dietmar; Allen, M. R.
    Anthropogenic greenhouse gas contribution to flood risk in England and Wales in autumn 2000
    In: Nature Vol. 470 (2011) Nr. 7334, pp. 382 - 385
    ISSN: 0028-0836; 1476-4687
    Online Full Text: dx.doi.org/
  • Dauwerse, Johannes G.; Dixon, Jill; Seland, Saskia; Ruivenkamp, Claudia A. L.; Van Haeringen, Arie; Hoefsloot, Lies H.; Peters, Dorien J. M.; Clement-de Boers, Agnes; Daumer-Haas, Cornelia; Maiwald, Robert; Zweier, Christiane; Kerr, Bronwyn; Cobo, Ana M.; Toral, Joaquín F.; Hoogeboom, A. Jeannette M.; Lohmann, Dietmar R.; Hehr, Ute; Dixon, Michael J.; Breuning, Martijn H.; Wieczorek, Dagmar
    Mutations in genes encoding subunits of RNA polymerases I and III cause Treacher Collins syndrome
    In: Nature Genetics Vol. 43 (2011) Nr. 1, pp. 20 - 22
    ISSN: 1061-4036; 1546-1718
    Online Full Text: dx.doi.org/
  • Khandanpour, Cyrus; Thiede, Christian; Valk, Peter J.; Sharif-Askari, Ehssan; Nückel, Holger; Lohmann, Dietmar; Horsthemke, Bernhard; Siffert, Winfried; Neubauer, Andreas; Grzeschik, Karl-Heinz; Bloomfield, Clara D.; Marcucci, Guido; Maharry, Kati; Slovak, Marilyn L.; van der Reijden, Bert A.; Jansen, Joop H.; Schackert, Hans K.; Afshar, Khashayar; Schnittger, Susanne; Peeters, Justine K.; Kroschinsky, Frank; Ehninger, Gerhard; Lowenberg, Bob; Dührsen, Ulrich; Möröy, Tarik
    A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia
    In: Blood Vol. 115 (2010) Nr. 12, pp. 2462 - 2472
    ISSN: 0006-4971; 1528-0020
    Online Full Text: dx.doi.org/
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