ZMB member Katharina Lückerath

ZMB Member
Katharina Lückerath

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Katharina Lückerath portrait
© K.Lückerath

Prof. Dr. Katharina Lückerath

Group

Clinic for Nuclear Medicine
University Hospital Essen
Hufelandstr. 55
45122 Essen

Research Overview

Our group focuses on theranostic approaches with the goal to deliver new insights into tumor biology, heterogeneity and metabolism and their relationship and relevance to functional imaging and biomarker-driven treatments in nuclear medicine.
Theranostics use radioligands that bind to cell surface receptors on target cells. Radioligands labeled with isotopes such as Gallium-68 or Fluor-18 enable imaging of target expression by positron emission tomography (PET). The same or a similar ligand labeled with alpha or beta radiation emitting isotopes delivers therapeutic radiation specifically to target expressing tissues (radionuclide therapy; RNT). In contrast to conventional radiotherapy, RNTs are systemically administered; as a consequence, metastases throughout the body can be targeted, and tumors are irradiated for hours to days.
Radionuclide therapy is a promising treatment option for various cancers. However, outcomes are rarely curative. We address this clinical need by investigating new RNT modalities and the mechanisms underlying the limited effectiveness of RNT. These mechanisms include, for example, tumor cell intrinsic resistance mechanisms, tumor protection by microenvironmental factors, and a suboptimal radiotherapeutic strategy. Poor understanding of these mechanisms represents a key barrier to the development of more effective RNT approaches. To improve radionuclide therapy outcomes and to establish rationally chosen, translatable RNT-based combination therapies, we characterize cancer mouse models and patient samples, and use diverse in vitro, ex vivo, and in vivo analyses to identify targetable RNT-induced alterations in tumor, stroma and immune cells that mitigate the effects of RNT and could be exploited therapeutically.
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Selected Publications

    Journal articles

  • Staniszewska, Magdalena; Iking, Janette; Lückerath, Katharina; Hadaschik, Boris; Herrmann, Ken; Ferdinandus, Justin; Fendler, Wolfgang
    Drug and molecular radiotherapy combinations for metastatic castration resistant prostate cancer
    In: Nuclear Medicine and Biology Vol. 96-97 (2021) pp. 101 - 111
    ISSN: 1872-9614; 0969-8051
  • Staniszewska, Magdalena; Fragoso Costa, Pedro; Eiber, Matthias; Klose, Jasmin M.; Wosniack, Jasmin; Reis, Henning; Szarvas, Tibor; Hadaschik, Boris; Lückerath, Katharina; Herrmann, Ken; Fendler, Wolfgang; Iking, Janette
    Enzalutamide enhances psma expression of psma-low prostate cancer
    In: International Journal of Molecular Sciences (IJMS) Vol. 22 (2021) Nr. 14,
    ISSN: 1422-0067; 1661-6596
  • Iking, Janette; Staniszewska, Magdalena; Kessler, Lukas; Klose, Jasmin M.; Lückerath, Katharina; Fendler, Wolfgang; Herrmann, Ken; Rischpler, Christoph
    Imaging Inflammation with Positron Emission Tomography
    In: Biomedicines Vol. 9 (2021) Nr. 2, pp. 212
    ISSN: 2227-9059
  • Czernin, Johannes; Current, Kyle; Mona, Christine E.; Nyiranshuti, Lea; Hikmat, Firas; Radu, Caius G.; Lückerath, Katharina
    Immune-Checkpoint Blockade Enhances ²²⁵Ac-PSMA617 Efficacy in a Mouse Model of Prostate Cancer
    In: Journal of Nuclear Medicine (JNM) Vol. 62 (2021) Nr. 2, pp. 228 - 231
    ISSN: 1535-5667; 0161-5505
  • Veach, Darren R.; Storey, Claire M.; Lückerath, Katharina; Braun, Katharina; von Bodman, Christian; Lamminmäki, Urpo; Kalidindi, Teja; Strand, Sven-Erik; Strand, Joanna; Altai, Mohamed; Damoiseaux, Robert; Zanzonico, Pat; Benabdallah, Nadia; Pankov, Dmitry; Scher, Howard I.; Scardino, Peter; Larson, Steven M.; Lilja, Hans; McDevitt, Michael R.; Thorek, Daniel L.J.; Ulmert, David
    PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates
    In: Clinical Cancer Research Vol. 27 (2021) Nr. 7, pp. 2050 - 2060
    ISSN: 1557-3265; 1078-0432
  • Bicak, Mesude; Lückerath, Katharina; Kalidindi, Teja; Phelps, Michael E.; Strand, Sven-Erik; Morris, Michael J.; Radu, Caius G.; Damoiseaux, Robert; Peltola, Mari T.; Peekhaus, Norbert; Ho, Austin; Veach, Darren; Malmborg Hager, Ann-Christin; Larson, Steven M.; Lilja, Hans; McDevitt, Michael R.; Klein, Robert J.; Ulmert, David
    Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted α-particle therapy
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 117 (2020) Nr. 26, pp. 15172 - 15181
    ISSN: 1091-6490; 0027-8424
  • Current, Kyle; Meyer, Catherine; Magyar, Clara E.; Mona, Christine E.; Almajano, Joel; Slavik, Roger; Stuparu, Andreea D.; Cheng, Chloe; Dawson, David W.; Radu, Caius G.; Czernin, Johannes; Lückerath, Katharina
    Investigating PSMA-Targeted Radioligand Therapy Efficacy as a Function of Cellular PSMA Levels and Intratumoral PSMA Heterogeneity
    In: Clinical Cancer Research Vol. 26 (2020) Nr. 12, pp. 2946 - 2955
    ISSN: 1557-3265; 1078-0432
  • Stuparu, Andreea D.; Capri, Joseph R.; Meyer, Catherine; Le, Thuc M.; Evans-Axelsson, Susan L.; Current, Kyle; Lennox, Mark; Mona, Christine E.; Fendler, Wolfgang; Calais, Jérémie; Eiber, Matthias; Dahlbom, Magnus; Czernin, Johannes; Radu, Caius G.; Lückerath, Katharina; Slavik, Roger
    Mechanisms of Resistance to Prostate-Specific Membrane Antigen-Targeted Radioligand Therapy in a Mouse Model of Prostate Cancer
    In: Journal of Nuclear Medicine (JNM) Vol. 62 (2020) Nr. 7, pp. 989 - 995
    ISSN: 1535-5667; 2159-662X
  • Stuparu, Andreea D.; Meyer, Catherine A.L.; Evans-Axelsson, Susan L.; Lückerath, Katharina; Wei, Liu H.; Kim, Woosuk; Poddar, Soumya; Mona, Christine E.; Dahlbom, Magnus; Girgis, Mark D.; Radu, Caius G.; Czernin, Johannes; Slavik, Roger
    Targeted alpha therapy in a systemic mouse model of prostate cancer : A feasibility study
    In: Theranostics Vol. 10 (2020) Nr. 6, pp. 2612 - 2620
    ISSN: 1838-7640
  • Lapa, Constantin; Lückerath, Katharina; Kircher, Stefan; Hänscheid, Heribert; Grigoleit, Götz U.; Rosenwald, Andreas; Stolzenburg, Antje; Kropf, Saskia; Einsele, Hermann; Wester, Hans-Jürgen; Buck, Andreas K.; Kortüm, Klaus M.; Schirbel, Andreas
    Potential influence of concomitant chemotherapy on CXCR4 expression in receptor directed endoradiotherapy
    In: British Journal of Haematology Vol. 184 (2019) Nr. 3, pp. 440 - 443
    ISSN: 0007-1048; 1365-2141
  • Lückerath, Katharina; Stuparu, Andreea D.; Wei, Liu; Kim, Woosuk; Radu, Caius G.; Mona, Christine E.; Calais, Jeremie; Rettig, Matthew; Reiter, Robert E.; Czernin, Johannes; Slavik, Roger; Herrmann, Ken; Eiber, Matthias; Fendler, Wolfgang P.
    Detection Threshold and Reproducibility of ⁶⁸Ga-PSMA11 PET/CT in a Mouse Model of Prostate Cancer
    In: Journal of Nuclear Medicine (JNM) Vol. 59 (2018) Nr. 9, pp. 1392 - 1397
    ISSN: 1535-5667; 0161-5505
  • Lückerath, Katharina; Wei, Liu; Fendler, Wolfgang; Evans-Axelsson, Susan; Stuparu, Andreea D.; Slavik, Roger; Mona, Christine E.; Calais, Jeremie; Rettig, Matthew; Reiter, Robert E.; Herrmann, Ken; Radu, Caius G.; Czernin, Johannes; Eiber, Matthias
    Preclinical evaluation of PSMA expression in response to androgen receptor blockade for theranostics in prostate cancer
    In: EJNMMI Research Vol. 8 (2018) pp. 96
    ISSN: 2191-219X
  • Lapa, Constantin; Herrmann, Ken; Schirbel, Andreas; Hänscheid, Heribert; Lückerath, Katharina; Schottelius, Margret; Kircher, Malte; Werner, Rudolf A.; Schreder, Martin; Samnick, Samuel; Kropf, Saskia; Knop, Stefan; Buck, Andreas K.; Einsele, Hermann; Wester, Hans-Juergen; Kortüm, K. Martin
    CXCR4-directed endoradiotherapy induces high response rates in extramedullary relapsed Multiple Myeloma
    In: Theranostics Vol. 7 (2017) Nr. 6, pp. 1589 - 1597
    ISSN: 1838-7640
  • Fendler, Wolfgang; Stuparu, Andreea D.; Evans-Axelsson, Susan; Lückerath, Katharina; Wei, Liu; Kim, Woosuk; Poddar, Soumya; Said, Jonathan; Radu, Caius G.; Eiber, Matthias; Czernin, Johannes; Slavik, Roger; Herrmann, Ken
    Establishing 177Lu-PSMA-617 Radioligand Therapy in a Syngeneic Model of Murine Prostate Cancer
    In: Journal of Nuclear Medicine (JNM) Vol. 58 (2017) Nr. 11, pp. 1786 - 1792
    ISSN: 1535-5667; 0161-5505; 0097-9058; 0022-3123; 2159-662X
  • Lapa, Constantin; Kircher, Stefan; Schirbel, Andreas; Rosenwald, Andreas; Kropf, Saskia; Pelzer, Theo; Walles, Thorsten; Buck, Andreas K.; Weber, Wolfgang A.; Wester, Hans-Juergen; Herrmann, Ken; Lückerath, Katharina
    Targeting CXCR4 with [68Ga]Pentixafor : A suitable theranostic approach in pleural mesothelioma?
    In: OncoTarget Vol. 8 (2017) Nr. 57, pp. 96732 - 96737
    ISSN: 1949-2553
  • Lapa, Constantin; Schreder, Martin; Schirbel, Andreas; Samnick, Samuel; Kortüm, Klaus Martin; Herrmann, Ken; Kropf, Saskia; Einsele, Herrmann; Buck, Andreas K; Wester, Hans-Jürgen; Knop, Stefan; Lückerath, Katharina
    [68Ga]Pentixafor-PET/CT for imaging of chemokine receptor CXCR4 expression in multiple myeloma - Comparison to [18F]FDG and laboratory values
    In: Theranostics Vol. 7 (2017) Nr. 1, pp. 205 - 212
    ISSN: 1838-7640
  • Lapa, Constantin; Garcia-Velloso, Maria J; Lückerath, Katharina; Samnick, Samuel; Schreder, Martin; Otero, Paula Rodriguez; Schmid, Jan-Stefan; Herrmann, Ken; Knop, Stefan; Buck, Andreas K; Einsele, Hermann; San-Miguel, Jesus; Kortüm, Klaus Martin
    ¹¹C-Methionine-PET in Multiple Myeloma : A Combined Study from Two Different Institutions
    In: Theranostics Vol. 7 (2017) Nr. 11, pp. 2956 - 2964
    ISSN: 1838-7640
  • Herrmann, Ken; Schottelius, Margret; Lapa, Constantin; Osl, Theresa; Poschenrieder, Andreas; Hänscheid, Heribert; Lückerath, Katharina; Schreder, Martin; Bluemel, Christina; Knott, Markus; Keller, Ulrich; Schirbel, Andreas; Samnick, Samuel; Lassmann, Michael; Kropf, Saskia; Buck, Andreas K.; Einsele, Hermann; Wester, Hans-Juergen; Knop, Stefan
    First-in-human experience of CXCR4-directed endoradiotherapy with ¹⁷⁷Lu-and ⁹⁰Y-labeled pentixather in advanced-stage multiple myeloma with extensive intra-and extramedullary disease
    In: Journal of Nuclear Medicine (JNM) Vol. 57 (2016) Nr. 2, pp. 248 - 251
    ISSN: 1535-5667; 0161-5505
  • Lapa, Constantin; Knop, Stefan; Schreder, Martin; Rudelius, Martina; Knott, Markus; Jörg, Gerhard; Samnick, Samuel; Herrmann, Ken; Buck, Andreas K.; Einsele, Hermann; Lückerath, Katharina
    ¹¹C-methionine-PET in multiple myeloma : Correlation with clinical parameters and bone marrow involvement
    In: Theranostics Vol. 6 (2016) Nr. 2, pp. 254 - 261
    ISSN: 1838-7640
  • Philipp-Abbrederis, Kathrin; Herrmann, Ken; Knop, Stefan; Schottelius, Margret; Eiber, Matthias; Lückerath, Katharina; Pietschmann, Elke; Habringer, Stefan; Gerngroß, Carlos; Franke, Katharina; Rudelius, Martina; Schirbel, Andreas; Lapa, Constantin; Schwamborn, Kristina; Steidle, Sabine; Hartmann, Elena; Rosenwald, Andreas; Kropf, Saskia; Beer, Ambros J.; Peschel, Christian; Einsele, Hermann; Buck, Andreas K.; Schwaiger, Markus; Götze, Katharina; Wester, Hans-Jürgen; Keller, Ulrich
    In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma
    In: EMBO Molecular Medicine Vol. 7 (2015) Nr. 4, pp. 477 - 487
    ISSN: 1757-4684; 1757-4676
  • Lückerath, Katharina; Lapa, Constantin; Albert, Christa; Herrmann, Ken; Jörg, Gerhard; Samnick, Samuel; Einsele, Herrmann; Knop, Stefan; Buck, Andreas K.
    ¹¹C-Methionine-PET : A novel and sensitive tool for monitoring of early response to treatment in multiple myeloma
    In: OncoTarget Vol. 6 (2015) Nr. 10, pp. 8418 - 8429
    ISSN: 1949-2553
  • Lapa, Constantin; Lückerath, Katharina; Malzahn, Uwe; Samnick, Samuel; Einsele, Herrmann; Buck, Andreas K.; Herrmann, Ken; Knop, Stefan
    ¹⁸FDG-PET/CT for prognostic stratification of patients with multiple myeloma relapse after stem cell transplantation
    In: OncoTarget Vol. 5 (2014) Nr. 17, pp. 7381 - 7391
    ISSN: 1949-2553
  • Lückerath, Katharina; Lapa, Constantin; Spahmann, Annika; Jörg, Gerhard; Samnick, Samuel; Rosenwald, Andreas; Einsele, Herrmann; Knop, Stefan; Buck, Andreas K.
    Targeting paraprotein biosynthesis for non-invasive characterization of myeloma biology
    In: PLoS ONE Vol. 8 (2013) Nr. 12, pp. e84840
    ISSN: 1932-6203
  • Lückerath, Katharina; Kirkin, Vladimir; Melzer, Inga Maria; Thalheimer, Frederic B.; Siele, Dagmar; Milani, Wiebke; Adler, Thure; Aguilar-Pimentel, Antonio; Horsch, Marion; Michel, Geert; Beckers, Johannes; Busch, Dirk H.; Ollert, Markus; Gailus-Durner, Valerie; Fuchs, Helmut; De Angelis, Martin Hrabě; Staal, Frank J. T.; Rajalingam, Krishnaraj; Hueber, Anne-Odile; Strobl, Lothar J.; Zimber-Strobl, Ursula; Zörnig, Martin
    Immune modulation by Fas ligand reverse signaling : Lymphocyte proliferation is attenuated by the intracellular Fas ligand domain
    In: Blood Vol. 117 (2011) Nr. 2, pp. 519 - 529
    ISSN: 0006-4971; 1528-0020
  • Kirkin, Vladimir; Cahuzac, Nathalie; Guardiola-Serrano, Francisca; Huault, Sébastien; Lückerath, Katharina; Friedmann, Elena Imre; Novac, Natalia; Wels, Winfried S.; Martoglio, Bruno; Hueber, Anne Odile; Zörnig, Martin
    The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells
    In: Cell Death and Differentiation Vol. 14 (2007) Nr. 9, pp. 1678 - 1687
    ISSN: 1350-9047; 1476-5403