ZMB Member Johann Matschke

ZMB Member
Johann Matschke

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Johann Matschke portrait
© J.Matschke

Dr. Johann Matschke

Group

Metabolism and Radiation Response

Institute of Cell Biology (Tumor Research)
University Hospital Essen
Virchowstr. 173
45122 Essen

Research Overview

Our research focuses on the role of metabolic reprogramming in cancer cells for intrinsic, microenvironment-induced, and adaptive radioresistance and the identification of associated specific metabolic vulnerabilities of cancer cells suited to improve the cytotoxic efficacy of radiotherapy.
Therefore, we have established various specific in vitro methods for the analysis and evaluation of radiobiology endpoints, cell metabolite levels, real-time metabolic fluxes in normoxia and hypoxia (Seahorse Bioanalyser). We also perform time-resolved metabolome analyses with national and inter-national cooperation partners. Long-term goal is to develop effective strategies for a targeted cancer cell radiosensitization and to identify associated stratification markers.
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Selected Publications

    Journal articles

  • Hansel, Christine; Hlouschek, Julian; Xiang, Kexu; Melnikova, Margarita; Thomale, Jürgen; Helleday, Thomas; Jendrossek, Verena; Matschke, Johann
    Adaptation to chronic-cycling hypoxia renders cancer cells resistant to mth1-inhibitor treatment which can be counteracted by glutathione depletion
    In: Cells Vol. 10 (2021) Nr. 11,
    ISSN: 2073-4409
    Online Full Text: dx.doi.org/ (Open Access)
  • Stein, Jan; Walkenfort, Bernd; Cihankaya, Hilal; Hasenberg, Mike; Bader, Verian; Winklhofer, Konstanze F.; Röderer, Pascal; Matschke, Johann; Theiss, Carsten; Matschke, Veronika
    Increased ROS-Dependent Fission of Mitochondria Causes Abnormal Morphology of the Cell Powerhouses in a Murine Model of Amyotrophic Lateral Sclerosis
    In: Oxidative Medicine and Cellular Longevity Vol. 2021 (2021)
    ISSN: 1942-0994; 1942-0900
    Online Full Text: dx.doi.org/ (Open Access)
  • Matschke, Johann; Larafa, Safa; Jendrossek, Verena
    Metabolic reprograming of antioxidant defense : A precision medicine perspective for radiotherapy of lung cancer?
    In: Biochemical Society Transactions Vol. 49 (2021) Nr. 3, pp. 1265 - 1277
    ISSN: 1470-8752; 0300-5127
    Online Full Text: dx.doi.org/
  • Krysztofiak, Adam; Szymonowicz, Klaudia; Hlouschek, Julian; Xiang, Kexu; Waterkamp, Christoph; Larafa, Safa; Goetting, Isabell; Vega-Rubin-de-Celis, Silvia; Theiss, Carsten; Matschke, Veronika; Hoffmann, Daniel; Jendrossek, Verena; Matschke, Johann
    Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown
    In: iScience Vol. 24 (2021) Nr. 11,
    ISSN: 2589-0042
    Online Full Text: dx.doi.org/ (Open Access)
  • Götting, Isabell; Jendrossek, Verena; Matschke, Johann
    A new twist in protein kinase b/akt signaling : Role of altered cancer cell metabolism in akt-mediated therapy resistance
    In: International Journal of Molecular Sciences (IJMS) Vol. 21 (2020) Nr. 22, pp. 8563
    ISSN: 1422-0067; 1661-6596
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Xiang, Kexu; Jendrossek, Verena; Matschke, Johann
    Oncometabolites and the response to radiotherapy
    In: Radiation Oncology Vol. 15 (2020) pp. 197
    ISSN: 1748-717X
    Online Full Text: dx.doi.org/ (Open Access)
  • Szymonowicz, Klaudia; Krysztofiak, Adam; van der Linden, Jansje; Kern, Ajvar; Deycmar, Simon; Oeck, Sebastian; Squire, Anthony; Koska, Benjamin; Hlouschek, Julian; Vüllings, Melanie; Neander, Christian; Siveke, Jens; Matschke, Johann; Pruschy, Martin; Timmermann, Beate; Jendrossek, Verena
    Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining
    In: Cells Vol. 9 (2020) Nr. 4, pp. 889
    ISSN: 2073-4409
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Matschke, Veronika; Theiss, Carsten; Matschke, Johann
    Oxidative stress: the lowest common denominator of multiple diseases
    In: Neural Regeneration Research Vol. 14 (2019) Nr. 2, pp. 238 - 241
    ISSN: 1876-7958; 1673-5374
    Online Full Text: dx.doi.org/ (Open Access)
  • Shannan, B.; Matschke, Johann; Chauvistré, Heike; Vogel, F.; Klein, Diana; Meier, Friedegund; Westphal, Dana; Bruns, Johannes; Rauschenberg, Ricarda; Utikal, Jochen; Forschner, Andrea; Berking, Carola; Terheyden, Patrick; Dabrowski, Evelyn; Gutzmer, Ralf; Rafei-Shamsabadi, David Ali; Meiss, Frank; Heinzerling, Lucie M.; Zimmer, Lisa; Livingstone, Elisabeth; Váraljai, Renáta; Hoewner, A.; Horn, Susanne; Klode, Joachim; Stuschke, Martin; Scheffler, Björn; Marchetto, Aruna; Sannino, Giuseppina; Grünewald, Thomas Georg Philipp; Schadendorf, Dirk; Jendrossek, Verena; Rösch, Alexander
    Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV⁶⁰⁰E inhibition in melanoma
    In: European Journal of Cancer Vol. 109 (2019) pp. 137 - 153
    ISSN: 1879-0852; 0959-8049
    Online Full Text: dx.doi.org/
  • Hlouschek, Julian; Ritter, Violetta; Wirsdörfer, Florian; Klein, Diana; Jendrossek, Verena; Matschke, Johann
    Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxia
    In: Cancer Letters Vol. 439 (2018) pp. 24 - 38
    ISSN: 0304-3835
    Online Full Text: dx.doi.org/
  • Hlouschek, Julian; Hansel, Christine; Jendrossek, Verena; Matschke, Johann
    The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia
    In: Frontiers in Oncology Vol. 8 (2018) pp. 170
    ISSN: 2234-943X
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Matschke, Johann; Wiebeck, Elisa; Hurst, Sebastian; Rudner, Justine; Jendrossek, Verena
    Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia
    In: Radiation Oncology Vol. 11 (2016) Nr. 1, pp. 75 - 87
    ISSN: 1748-717X
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Matschke, Johann; Riffkin, Helena; Klein, Diana; Handrick, René; Lüdemann, Lutz; Metzen, Eric; Shlomi, Tomer; Stuschke, Martin; Jendrossek, Verena
    Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling Hypoxia
    In: Antioxidants and Redox Signaling Vol. 25 (2016) Nr. 2, pp. 89 - 107
    ISSN: 1523-0864; 1557-7716
    Online Full Text: dx.doi.org/
  • Matschke, Veronika; Piccini, Ilaria; Schubert, Janina; Wrobel, Eva; Lang, Florian; Matschke, Johann; Amedonu, Elsie; Meuth, Sven G; Strünker, Timo; Strutz-Seebohm, Nathalie; Greber, Boris; Scherkenbeck, Jürgen; Seebohm, Guiscard
    The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels
    In: Cellular Physiology and Biochemistry Vol. 40 (2016) Nr. 6, pp. 1549 - 1558
    ISSN: 1015-8987; 1421-9778
    Online Full Text: dx.doi.org/ (Open Access)
  • Matschke, Johann; Riffkin, H.; Handrick, R.; Klein-Hitpaß, Ludger; Jendrossek, Verena
    Chronic intermittent hypoxia triggers adaptive changes that promote protection against cell death
    In: European Journal of Cancer Vol. 49 (2013) Nr. Suppl. 2, pp. 101
    ISSN: 0959-8049
    Online Full Text: dx.doi.org/
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