ZMB Member Johann Matschke

ZMB Member
Johann Matschke

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Johann Matschke portrait
© J.Matschke

Dr. Johann Matschke

Institute of Cell Biology (Tumor Research)
University Hospital Essen
Virchowstr. 173
45122 Essen

Research Overview

Our research focuses on the role of metabolic reprogramming in cancer cells for intrinsic, microenvironment-induced, and adaptive radioresistance and the identification of associated specific metabolic vulnerabilities of cancer cells suited to improve the cytotoxic efficacy of radiotherapy.
Therefore, we have established various specific in vitro methods for the analysis and evaluation of radiobiology endpoints, cell metabolite levels, real-time metabolic fluxes in normoxia and hypoxia (Seahorse Bioanalyser). We also perform time-resolved metabolome analyses with national and inter-national cooperation partners. Long-term goal is to develop effective strategies for a targeted cancer cell radiosensitization and to identify associated stratification markers.
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Selected Publications

    Journal articles

  • Götting, Isabell; Jendrossek, Verena; Matschke, Johann
    A new twist in protein kinase b/akt signaling : Role of altered cancer cell metabolism in akt-mediated therapy resistance
    In: International Journal of Molecular Sciences (IJMS) Vol. 21 (2020) Nr. 22, pp. 8563
    ISSN: 1422-0067; 1661-6596
  • Xiang, Kexu; Jendrossek, Verena; Matschke, Johann
    Oncometabolites and the response to radiotherapy
    In: Radiation Oncology Vol. 15 (2020) pp. 197
    ISSN: 1748-717X
  • Szymonowicz, Klaudia; Krysztofiak, Adam; van der Linden, Jansje; Kern, Ajvar; Deycmar, Simon; Oeck, Sebastian; Squire, Anthony; Koska, Benjamin; Hlouschek, Julian; Vüllings, Melanie; Neander, Christian; Siveke, Jens; Matschke, Johann; Pruschy, Martin; Timmermann, Beate; Jendrossek, Verena
    Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining
    In: Cells Vol. 9 (2020) Nr. 4, pp. 889
    ISSN: 2073-4409
  • Matschke, Veronika; Theiss, Carsten; Matschke, Johann
    Oxidative stress: the lowest common denominator of multiple diseases
    In: Neural Regeneration Research Vol. 14 (2019) Nr. 2, pp. 238 - 241
    ISSN: 1876-7958; 1673-5374
  • Shannan, B.; Matschke, Johann; Chauvistré, Heike; Vogel, F.; Klein, Diana; Meier, Friedegund; Westphal, Dana; Bruns, Johannes; Rauschenberg, Ricarda; Utikal, Jochen; Forschner, Andrea; Berking, Carola; Terheyden, Patrick; Dabrowski, Evelyn; Gutzmer, Ralf; Rafei-Shamsabadi, David Ali; Meiss, Frank; Heinzerling, Lucie M.; Zimmer, Lisa; Livingstone, Elisabeth; Váraljai, Renáta; Hoewner, A.; Horn, Susanne; Klode, Joachim; Stuschke, Martin; Scheffler, Björn; Marchetto, Aruna; Sannino, Giuseppina; Grünewald, Thomas Georg Philipp; Schadendorf, Dirk; Jendrossek, Verena; Rösch, Alexander
    Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV⁶⁰⁰E inhibition in melanoma
    In: European Journal of Cancer Vol. 109 (2019) pp. 137 - 153
    ISSN: 1879-0852; 0959-8049
  • Hlouschek, Julian; Ritter, Violetta; Wirsdörfer, Florian; Klein, Diana; Jendrossek, Verena; Matschke, Johann
    Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxia
    In: Cancer Letters Vol. 439 (2018) pp. 24 - 38
    ISSN: 0304-3835
  • Hlouschek, Julian; Hansel, Christine; Jendrossek, Verena; Matschke, Johann
    The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia
    In: Frontiers in Oncology Vol. 8 (2018) pp. 170
    ISSN: 2234-943X
  • Matschke, Johann; Wiebeck, Elisa; Hurst, Sebastian; Rudner, Justine; Jendrossek, Verena
    Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia
    In: Radiation Oncology Vol. 11 (2016) Nr. 1, pp. 75 - 87
    ISSN: 1748-717X
  • Matschke, Johann; Riffkin, Helena; Klein, Diana; Handrick, René; Lüdemann, Lutz; Metzen, Eric; Shlomi, Tomer; Stuschke, Martin; Jendrossek, Verena
    Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling Hypoxia
    In: Antioxidants and Redox Signaling Vol. 25 (2016) Nr. 2, pp. 89 - 107
    ISSN: 1523-0864; 1557-7716
  • Matschke, Veronika; Piccini, Ilaria; Schubert, Janina; Wrobel, Eva; Lang, Florian; Matschke, Johann; Amedonu, Elsie; Meuth, Sven G; Strünker, Timo; Strutz-Seebohm, Nathalie; Greber, Boris; Scherkenbeck, Jürgen; Seebohm, Guiscard
    The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels
    In: Cellular Physiology and Biochemistry Vol. 40 (2016) Nr. 6, pp. 1549 - 1558
    ISSN: 1015-8987; 1421-9778
  • Matschke, Johann; Riffkin, H.; Handrick, R.; Klein-Hitpaß, Ludger; Jendrossek, Verena
    Chronic intermittent hypoxia triggers adaptive changes that promote protection against cell death
    In: European Journal of Cancer Vol. 49 (2013) Nr. Suppl. 2, pp. 101
    ISSN: 0959-8049