ZMB Member Hemmo Meyer

ZMB Member
Hemmo Meyer

Next ZMB-Member
portrait photo of ZMB member Hemmo Meyer
© UDE

Prof. Dr. Hemmo Meyer

Group

Molecular Biology I

Center of Medical Biotechnology (ZMB)
Faculty of Biology
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen

Research Overview

Cellular homeostasis, proliferation and stress responses

Cells need to cope with a multitude of stress conditions that relentlessly inflict damage to its most vital components. This includes insults to the DNA that threatens genome stability, damage of proteins that can then form toxic aggregates, or injury of whole organelles such as mitochondria and lysosomes that releases harmful components. Cells have developed sophisticated molecular responses to these stresses that maintain protein homeostasis and organelle function, and ensure genomic stability. We are interested in deciphering these responses and uncover how they counteract stress-induced cell death and aging-related degeneration, or maintain cell proliferation.

The ubiquitin-proteasome system (UPS) is critically involved in cellular stress responses. Ubiquitination triggers degradation of damaged proteins by the proteasome, or removal of protein aggregates or hole organelles in the lysosome through autophagy. In addition, it regulates signalling pathways such as the DNA damage response and coordinates them with cell cycle progression.

A focus of our research has been the AAA+-type ATPase VCP/p97, which has emerged as a pivotal element of the UPS. It governs a variety of processes such as ER-associated degradation, ribosomal quality control, DNA damage responses as well as autophagy. Mutations in VCP/p97 in humans cause degenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), while pharmacological inhibition of VCP/p97 is considered as a strategy in cancer therapy. We have been working to reveal the molecular function of VCP/p97 and to understand how it cooperates with a host of accessory factors to trigger diverse stress responses in different compartments.

Keywords:
Cellular stress responses, proteostasis, ubiquitin-proteasome system, autophagy, lysosomal membrane permeabilization, lysophagy, mitophagy, DNA damage response, double strand break repair, cell cycle regulation.

Distribution of published plasmids through addgene.org.

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Selected Publications

    Journal articles

  • Peck, A.; Dadi, A.; Yavarow, Z.; Alfano, L.N.; Anderson, D.; Arkin, M.R.; Chou, T.F.; D'Ambrosio, E.S.; Diaz-Manera, J.; Dudley, J.P.; Elder, A.G.; Ghoshal, N.; Hart, C.E.; Hart, M.M.; Huryn, D.M.; Johnson, A.E.; Jones, K.B.; Kimonis, V.; Kiskinis, E.; Lee, E.B.; Lloyd, T.E.; Mapstone, M.; Martin, A.; Meyer, Hemmo; Mozaffar, T.; Onyike, C.U.; Pfeffer, G.; Pindon, A.; Raman, M.; Richard, I.; Rubinsztein, D.C.; Schiava, M.; Schütz, A.K.; Shen, P.S.; Southworth, D.R.; Staffaroni, A.M.; Taralio-Gravovac, M.; Weihl, C.C.; Yao, Q.; Ye, Y.; Peck, N.
    2024 VCP International Conference : Exploring multi-disciplinary approaches from basic science of valosin containing protein, an AAA+ ATPase protein, to the therapeutic advancement for VCP-associated multisystem proteinopathy
    In: Neurobiology of Disease , Vol. 207 2025, 106861
    DOI (Open Access)
  • Banerjee, Sudakshina; Cakil, Zeyneb Vildan; Gallant, Kai; van den Boom, Johannes; Palei, Shubhendu; Meyer, Hemmo; Gersch, Malte; Summerer, Daniel
    Light-Activatable Ubiquitin for Studying Linkage-Specific Ubiquitin Chain Formation Kinetics
    In: Advanced Science , Vol. 12 2025, Nr. 6, 2406570
    DOI (Open Access)
  • Kirupakaran, Abbna; van den Boom, Johannes; Blueggel, Mike; Beuck, Christine; Niemeyer, Felix; Hayduk, Matthias; Balszuweit, Jan; Bayer, Peter; Voskuhl, Jens; Meyer, Hemmo; Schrader, Thomas
    Molecular Tweezers Block the Functional Pore of a Protein Machine
    In: Journal of the American Chemical Society: JACS , Vol. 147 2025, Nr. 20, pp. 16836 – 16849
    DOI (Open Access)
  • Huang, Jing; Jaekel, Andreas; van den Boom, Johannes; Podlesainski, David; Elnaggar, M.; Heuer-Jungemann, A.; Kaiser, Markus; Meyer, Hemmo; Saccà, Barbara
    A modular DNA origami nanocompartment for engineering a cell-free, protein unfolding and degradation pathway
    In: Nature Nanotechnology , Vol. 19 2024, Nr. 10, pp. 1521 – 1531
    DOI (Open Access)
  • Kück, Anja; van den Boom, Johannes; Koska, Sandra; Ron, David; Meyer, Hemmo
    Alternating binding and p97-mediated dissociation of SDS22 and I3 recycles active PP1 between holophosphatases
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 121 2024, Nr. 36, e2408787121
    DOI (Open Access)
  • Gahlot, Pinki; Kravic, Bojana; Rota, Giulia; van den Boom, Johannes; Levantovsky, Sophie; Schulze, Nina; Maspero, Elena; Polo, Simona; Behrends, Christian; Meyer, Hemmo
    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
    In: Molecular Cell 2024, pp. 1556 – 1569.e10
    DOI, Online Full Text (Open Access)
  • Meyer, Hemmo; Kravic, Bojana
    The Endo-Lysosomal Damage Response
    In: Annual Review of Biochemistry , Vol. 93 2024, Nr. 1, pp. 367 – 387
    DOI (Open Access)
  • Mirsanaye, Ann Schirin; Hoffmann, Saskia; Weisser, Melanie; Mund, Andreas; Lopez Mendez, Blanca; Typas, Dimitris; van den Boom, Johannes; Benedict, Bente; Hendriks, Ivo A.; Nielsen, Michael Lund; Meyer, Hemmo; Duxin, Julien P.; Montoya, Guillermo; Mailand, Niels
    VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates
    In: Nature Communications , Vol. 15 2024, Nr. 1, 2459
    DOI (Open Access)
  • van den Boom, Johannes; Marini, Guendalina; Meyer, Hemmo; Saibil, Helen R
    Structural basis of ubiquitin-independent PP1 complex disassembly by p97
    In: The EMBO Journal , Vol. 42 2023, Nr. 14, e113110
    DOI (Open Access)
  • Meyer, Hemmo; van den Boom, Johannes
    Targeting of client proteins to the VCP/p97/Cdc48 unfolding machine
    In: Frontiers in Molecular Biosciences , Vol. 10 2023, 1142989
    DOI, Online Full Text (Open Access)
  • Blüggel, Mike; Kröning, Alexander; Kracht, Matthias; van den Boom, Johannes; Dabisch, Matthias; Göhring, Anna; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter; Meyer, Hemmo; Beuck, Christine
    The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPase
    In: Nature Communications , Vol. 14 2023, Nr. 1, 3258
    DOI, Online Full Text (Open Access)
  • Seaayfan, Elie; Nasrah, Sadiq; Quell, Lea; Kleim, Maja; Weber, Stefanie; Meyer, Hemmo; Laghmani, Kamel; Kömhoff, Martin
    MAGED2 Is Required under Hypoxia for cAMP Signaling by Inhibiting MDM2-Dependent Endocytosis of G-Alpha-S
    In: Cells , Vol. 11 2022, Nr. 16, 2546
    DOI (Open Access)
  • Kravić, Bojana; Bionda, Tihana; Siebert, Alexander; Gahlot, Pinki; Levantovsky, Sophie; Behrends, Christian; Meyer, Hemmo
    Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1
    In: Molecular Cell , Vol. 82 2022, Nr. 14, pp. 2633 – 2649.e7
    DOI (Open Access)
  • Kröning, Alexander; van den Boom, Johannes; Kracht, Matthias; Kück, Anja; Meyer, Hemmo
    Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTN
    In: The Journal of Biological Chemistry (JBC) , Vol. 298 2022, Nr. 6, 101976
    DOI (Open Access)
  • Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Buitrago-Molina, Laura Elisa; Lu, Mengji; Meyer, Hemmo; Tong, Chun-Kit
    Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
    In: Autophagy , Vol. 17 2021, Nr. 1, pp. 1 – 382
    DOI (Open Access)
  • van den Boom, Johannes; Kück, Anja; Kravic, Bojana; Müschenborn, Helen; Giesing, Maike; Pan, Dongqing; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Meyer, Hemmo
    Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly
    In: Nature Structural & Molecular Biology , Vol. 28 2021, Nr. 12, pp. 964 – 971
    DOI
  • Kollenda, Sebastian; Kopp, Mathis; Wens, Jasmin; Koch, Johannes; Schulze, Nina; Papadopoulos, Chrisovalantis; Pöhler, Robert; Meyer, Hemmo; Epple, Matthias
    A pH-sensitive fluorescent protein sensor to follow the pathway of calcium phosphate nanoparticles into cells
    In: Acta Biomaterialia , Vol. 111 2020, pp. 406 – 417
    DOI
  • Kracht, Matthias; van den Boom, Johannes; Seiler, Jonas; Kröning, Alexander; Kaschani, Farnusch; Kaiser, Markus; Meyer, Hemmo
    Protein Phosphatase-1 Complex Disassembly by p97 is Initiated through Multivalent Recognition of Catalytic and Regulatory Subunits by the p97 SEP-domain Adapters
    In: Journal of Molecular Biology (JMB) , Vol. 432 2020, Nr. 23, pp. 6061 – 6074
    DOI
  • Kravic, Bojana; Behrends, Christian; Meyer, Hemmo
    Regulation of lysosome integrity and lysophagy by the ubiquitin-conjugating enzyme UBE2QL1
    In: Autophagy , Vol. 16 2020, Nr. 1, pp. 179 – 180
    DOI (Open Access)
  • Papadopoulos, Chrisovalantis; Kravic, Bojana; Meyer, Hemmo
    Repair or Lysophagy : Dealing with Damaged Lysosomes
    In: Journal of Molecular Biology (JMB) , Vol. 432 2020, Nr. 1, pp. 231 – 239
    DOI
  • Krahn, Daniel; Heilmann, Geronimo; Vogel, Felix C. E.; Papadopoulos, Chrisovalantis; Zweerink, Susanne; Kaschani, Farnusch; Meyer, Hemmo; Rösch, Alexander; Kaiser, Markus
    Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product Family
    In: Chemistry - A European Journal , Vol. 26 2020, Nr. 39, pp. 8524 – 8531
    DOI (Open Access)
  • Blüggel, Mike; van den Boom, Johannes; Meyer, Hemmo; Bayer, Peter; Beuck, Christine
    Structure of the PUB Domain from Ubiquitin Regulatory X Domain Protein 1 (UBXD1) and Its Interaction with the p97 AAA+ ATPase
    In: Biomolecules , Vol. 9 2019, Nr. 12, 876
    DOI, Online Full Text (Open Access)
  • Körver, Lisa; Papadopoulos, Chrisovalantis; Liu, Bin; Kravic, Bojana; Rota, Giulia; Brecht, Lukas; Veenendaal, Tineke; Polajnar, Mira; Blümke, Anika; Ehrmann, Michael; Klumperman, Judith; Jäättelä, Marja; Behrends, Christian; Meyer, Hemmo
    The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage
    In: EMBO Reports 2019, pp. e48014
    DOI (Open Access)
  • Arhzaouy, Khalid; Papadopoulos, Chrisovalantis; Schulze, Nina; Pittman, Sara K.; Meyer, Hemmo; Weihl, Conrad C.
    VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle
    In: Autophagy , Vol. 15 2019, Nr. 6, pp. 1082 – 1099
    DOI (Open Access)
  • Pöhler, Robert; Krahn, Jan; van den Boom, Johannes; Dobrynin, Grzegorz; Kaschani, Farnusch; Eggenweiler, Hans-Michael; Zenke, Frank T.; Kaiser, Markus; Meyer, Hemmo
    A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases
    In: Angewandte Chemie International Edition , Vol. 57 2018, Nr. 6, pp. 1576 – 1580
    DOI
  • Hülsmann, Julia; Kravic, Bojana; Weith, Matthias; Gstaiger, Matthias; Aebersold, Ruedi; Collins, Ben C.; Meyer, Hemmo
    AP-SWATH reveals direct involvement of VCP/ p97 in integrated stress response signaling through facilitating CReP/PPP1R15B degradation
    In: Molecular and Cellular Proteomics (MCP) , Vol. 17 2018, Nr. 7, pp. 1295 – 1307
    DOI (Open Access)
  • Weith, Matthias; Seiler, Jonas; van den Boom, Johannes; Kracht, Matthias; Hülsmann, Julia; Primorac, Ivana; Del Pino Garcia, Javier; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Bollen, Mathieu; Meyer, Hemmo
    Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation
    In: Molecular Cell , Vol. 72 2018, Nr. 4, pp. 766 – 777
    DOI (Open Access)
  • van den Boom, Johannes; Meyer, Hemmo
    VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling
    In: Molecular Cell , Vol. 69 2018, Nr. 2, pp. 182 – 194
    DOI (Open Access)
  • Kopp, Mathis; Rotan, Olga; Papadopoulos, Chrisovalantis; Schulze, Nina; Meyer, Hemmo; Epple, Matthias
    Delivery of the autofluorescent protein R-phycoerythrin by calcium phosphate nanoparticles into four different eukaryotic cell lines (HeLa, HEK293T, MG-63, MC3T3) : Highly efficient, but leading to endolysosomal proteolysis in HeLa and MC3T3 cells
    In: PLoS ONE , Vol. 12 2017, Nr. 6, pp. e0178260
    DOI (Open Access)
  • Papadopoulos, Chrisovalantis; Meyer, Hemmo
    Detection and Clearance of Damaged Lysosomes by the Endo-Lysosomal Damage Response and Lysophagy
    In: Current Biology , Vol. 27 2017, Nr. 24, pp. R1330 – R1341
    DOI
  • Papadopoulos, Chrisovalantis; Kirchner, Philipp; Bug, Monika; Grum, Daniel; Körver, Lisa; Schulze, Nina; Pöhler, Robert; Dressler, Alina; Fengler, Sven; Arhzaouy, Khalid; Lux, Vanda; Ehrmann, Michael; Weihl, Conrad C.; Meyer, Hemmo
    VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy
    In: The EMBO Journal , Vol. 36 2017, Nr. 2, pp. 135 – 150
    DOI (Open Access)
  • Trusch, Franziska; Kowski, Klaus; Bravo-Rodriguez, Kenny; Beuck, Christine; Sowislok, Andrea; Wettig, Burkhard; Matena, Anja; Sánchez-García, Elsa; Meyer, Hemmo; Schrader, Thomas; Bayer, Peter
    Molecular tweezers target a protein-protein interface and thereby modulate complex formation
    In: Chemical Communications: ChemComm , Vol. 52 2016, Nr. 98, pp. 14141 – 14144
    DOI (Open Access)
  • van den Boom, Johannes; Wolf, Markus; Weimann, Lena; Schulze, Nina; Li, Fanghua; Kaschani, Farnusch; Riemer, Anne; Zierhut, Christian; Kaiser, Markus; Iliakis, George; Funabiki, Hironori; Meyer, Hemmo
    VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair
    In: Molecular Cell , Vol. 64 2016, Nr. 1, pp. 189 – 198
    DOI (Open Access)
  • Trusch, Franziska; Matena, Anja; Vuk, Maja; Körver, Lisa; Knævelsrud, Helene; Freemont, Paul S.; Meyer, Hemmo; Bayer, Peter
    The N-terminal region of the ubiquitin regulatory X (UBX) domain-containing protein 1 (UBXD1) modulates interdomain communication within the valosin-containing protein p97
    In: The Journal of Biological Chemistry (JBC) , Vol. 290 2015, Nr. 49, pp. 29414 – 29427
    DOI (Open Access)
  • Eiteneuer, Annika; Seiler, Jonas; Weith, Matthias; Beullens, Monique; Lesage, Bart; Krenn, Veronica; Musacchio, Andrea; Bollen, Mathieu; Meyer, Hemmo
    Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1
    In: The EMBO Journal , Vol. 33 2014, Nr. 22, pp. 2704 – 2720
    DOI (Open Access)
  • Meyer, Hemmo; Weihl, Conrad C.
    The VCP/p97 system at a glance : connecting cellular function to disease pathogenesis
    In: Journal of Cell Science , Vol. 127 2014, Nr. 18, pp. 3877 – 3883
    DOI
  • Dressler, A.; Riemer, Anne; Dobrynin, Grzegorz; Bremer, Sebastian; Soni, A.; Iliakis, George; Meyer, Hemmo
    The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation
    In: The FEBS Journal , Vol. 281 2014, Nr. Suppl. 1, pp. 82
    DOI
  • Riemer, Anne; Dobrynin, Grzegorz; Dressler, Alina; Bremer, Sebastian; Soni, Aashish; Iliakis, George; Meyer, Hemmo
    The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation
    In: Cell Cycle , Vol. 13 2014, Nr. 6, pp. 919 – 927
    DOI (Open Access)
  • Ehrenhofer-Murray, Ann; Meyer, Hemmo; Nellen, Wolfgang
    Coal mining meets chromatin research: Digging for mechanisms in epigenetic control of gene expression : Report from the 43rd Annual Meeting of the German Genetics Society on "Chromatin and Epigenetics" in Essen, Germany
    In: BioEssays , Vol. 35 2013, Nr. 2, pp. 141 – 144
    DOI
  • Kress, Elsa; Schwager, Françoise; Holtackers, René; Seiler, Jonas; Prodon, François; Zanin, Esther; Eiteneues, Annika; Toya, Mika; Sugimoto, Asako; Meyer, Hemmo; Meraladi, Patrick; Gotta, Monica
    The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A
    In: The Journal of Cell Biology (JCB) , Vol. 201 2013, Nr. 4, pp. 559 – 575
    DOI
  • Kirchner, Philipp; Bug, Monika; Meyer, Hemmo
    Ubiquitination of the n-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPase
    In: The Journal of Biological Chemistry (JBC) , Vol. 288 2013, Nr. 10, pp. 7363 – 7372
    DOI
  • Bebeacua, Cecilia; Förster, Andreas; McKeown, Ciarán; Meyer, Hemmo; Zhang, Xiaodong; Freemont, Paul S.
    Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 109 2012, pp. 1098 – 1103.
    DOI (Open Access)
  • Meyer, Hemmo; Bug, Monika; Bremer, Sebastian
    Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system
    In: Nature Cell Biology , Vol. 14 2012, Nr. 2, pp. 117 – 123
    DOI
  • Bug, Monika; Meyer, Hemmo
    Expanding into new markets – VCP/p97 in endocytosis and autophagy
    In: Journal of Structural Biology , Vol. 179 2012, Nr. 2, pp. 78 – 82
    DOI
  • Meyer, Hemmo
    p97 complexes as signal integration hubs
    In: BMC Biology (incorporating Journal of Biology) , Vol. 10 2012, pp. 48
    DOI, Online Full Text (Open Access)
  • Dobrynin, Grzegorz; Popp, Oliver; Romer, Tina; Bremer, Sebastian; Schmitz, Michael H. A.; Gerlich, Daniel W.; Meyer, Hemmo
    Cdc48/p97-Ufd1-Npl4 antagonizes Aurora B during chromosome segregation in HeLa cells.
    In: Journal of Cell Science , Vol. 124 2011, Nr. 9, pp. 1571 – 1580
    DOI
  • Ritz, Danilo; Vuk, Maja; Kirchner, Philipp; Bug, Monika; Schütz, Sabina; Hayer, Arnold; Bremer, Sebastian; Lusk, Caleb; Baloh, Robert H.; Lee, Houkeun; Glatter, Timo; Gstaiger, Matthias; Aebersold, Ruedi; Weihl, Conrad C.; Meyer, Hemmo
    Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations
    In: Nature Cell Biology , Vol. 13 2011, Nr. 9, pp. 1116 – 1123
    DOI
  • Meerang, Mayura; Ritz, Danilo; Paliwal, Shreya; Garajova, Zuzana; Bosshard, Matthias; Mailand, Niels; Janscak, Pavel; Hübscher, Ulrich; Meyer, Hemmo; Ramadan, Kristijan
    The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks
    In: Nature Cell Biology , Vol. 13 2011, Nr. 11, pp. 1376 – 1382
    DOI
  • Meyer, Hemmo; Drozdowska, Alicja; Dobrynin, Grzegorz
    A role for Cdc48/p97 and Aurora B in controlling chromatin condensation during exit from mitosis
    In: Biochemistry and Cell Biology , Vol. 88 2010, Nr. 1, pp. 23 – 28
    DOI
  • Hayer, Arnold; Stoeber, Miriam; Ritz, Danilo; Engel, Sabrina; Meyer, Hemmo; Helenius, Ari
    Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation
    In: The Journal of Cell Biology (JCB) , Vol. 191 2010, Nr. 3, pp. 615 – 629
    DOI
  • Meyer, Hemmo; Popp, Oliver
    Role(s) of Cdc48/p97 in mitosis
    In: Biochemical Society Transactions , Vol. 36 2008, Nr. 1, pp. 126 – 130
  • Ramadan, Kristijan; Bruderer, Roland; Spiga, Fabio M.; Popp, Oliver; Baur, Tina; Gotta, Monica; Meyer, Hemmo
    Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin
    In: Nature , Vol. 450 2007, Nr. 7173, pp. 1258
  • Isaacson, Rivka L.; Pye, Valerie E.; Simpson, Peter; Meyer, Hemmo; Zhang, Xiaodong; Freemont, Paul S.; Matthews, Steve
    Detailed structural insights into the p97-Npl4-Ufd1 interface
    In: The Journal of Biological Chemistry (JBC) , Vol. 282 2007, Nr. 29, pp. 21361 – 21369
  • Baur, Tina; Ramadan, Kristijan; Schlundt, Andreas; Kartenbeck, Jürgen; Meyer, Hemmo
    NSF- and SNARE-mediated membrane fusion is required for nuclear envelope formation and completion of nuclear pore complex assembly in Xenopus laevis egg extracts
    In: Journal of Cell Science , Vol. 120 2007, Nr. 16, pp. 2895 – 2903
  • Pye, Valerie E.; Beuron, Fabienne; Keetch, Catherine A.; McKeown, Ciaran; Robinson, Carol V.; Meyer, Hemmo; Zhang, Xiaodong; Freemont, Paul S.
    Structural insights into the p97-Ufd1-NpI4 complex
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 104 2007, Nr. 2, pp. 467 – 472
  • Meyer, Hemmo
    Golgi reassembly after mitosis : The AAA family meets the ubiquitin family
    In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research , Vol. 1744 2005, Nr. 2, pp. 108 – 119
    DOI (Open Access)
  • Bruderer, Roland M.; Brasseur, Catherine; Meyer, Hemmo
    The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism
    In: The Journal of Biological Chemistry (JBC) , Vol. 279 2004, Nr. 48, pp. 49609 – 49616
  • Alam, Steven L; Sun, Ji; Payne, Marielle; Welch, Brett D; Blake, B Kelly; Davis, Darrell R; Meyer, Hemmo; Emr, Scott D; Sundquist, Wesley I
    Ubiquitin Interactions of NZF Zinc Fingers
    In: The EMBO Journal , Vol. 23 2004, Nr. 7, pp. 1411 – 1421
  • Wang, Yanzhuang; Satoh, Ayano; Warren, Graham; Meyer, Hemmo
    VCIP135 acts as a deubiquitinating enzyme during p97–p47-mediated reassembly of mitotic Golgi fragments
    In: The Journal of Cell Biology (JCB) , Vol. 164 2004, Nr. 7, pp. 973 – 978
  • Ye, Yihong; Meyer, Hemmo; Rapoport, Tom A.
    Function of the p97–Ufd1–Npl4 complex in retrotranslocation from the ER to the cytosol : dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains
    In: The Journal of Cell Biology (JCB) , Vol. 162 2003, Nr. 1, pp. 71 – 84
    DOI
  • Wang, Bin; Alam, Steven L.; Meyer, Hemmo; Payne, Marielle; Stemmler, Timothy L.; Davis, Darrell R.; Sundquist, Wesley I.
    Structure and Ubiquitin Interactions of the Conserved Zinc Finger Domain of Npl4
    In: The Journal of Biological Chemistry (JBC) , Vol. 278 2003, pp. 20225 – 20234
  • Cao, Kan; Nakajima, Reiko; Meyer, Hemmo; Zheng, Yixian
    The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis
    In: Cell , Vol. 115 2003, Nr. 3, pp. 355 – 367
  • Meyer, Hemmo; Wang, Yanzhuang; Warren, Graham
    Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1–Npl4
    In: The EMBO Journal , Vol. 21 2002, Nr. 21, pp. 5645 – 5652.
  • Hetzer, Martin; Meyer, Hemmo; Walther, Tobias C.; Bilbao-Cortes, Daniel; Warren, Graham; Mattaj, Iain W.
    Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly
    In: Nature Cell Biology , Vol. 3 2001, Nr. 12, pp. 1086 – 1091
  • Ye, Yihong; Meyer, Hemmo; Rapoport, Tom A.
    The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
    In: Nature , Vol. 414 2001, pp. 652 – 656
  • Meyer, Hemmo; Shorter, James G.; Seemann, Joachim; Pappin, Darryl; Warren, Graham
    A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways
    In: The EMBO Journal , Vol. 19 2000, Nr. 10, pp. 2181 – 2192
  • Zhang, Xiaodong; Shaw, Anthony; Bates, Paul A.; Newman, Richard H.; Gowen, Brent; Orlova, Elena; Gorman, Michael A.; Kondo, Hisao; Dokurno, Pawel; Lally, John; Leonard, Gordon; Meyer, Hemmo; van Heel, Marin; Freemont, Paul S.
    Structure of the AAA ATPase p97
    In: Molecular Cell , Vol. 6 2000, Nr. 6, pp. 1473 – 1484
    DOI
  • Müller, Joyce M.; Meyer, Hemmo; Ruhrberg, Christiana; Stamp, Gordon W.; Warren, Graham; Shima, David T.
    The mouse p97 (CDC48) gene. Genomic structure, definition of transcriptional regulatory sequences, gene expression, and characterization of a pseudogene.
    In: The Journal of Biological Chemistry (JBC) , Vol. 274 1999, Nr. 15, pp. 10154 – 10162
  • Meyer, Hemmo; Kondo, Hisao; Warren, Graham
    The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97
    In: FEBS Letters , Vol. 437 1998, Nr. 3, pp. 255 – 257
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