Repair or Lysophagy : Dealing with Damaged Lysosomes

The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation

VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling

Detection and Clearance of Damaged Lysosomes by the Endo-Lysosomal Damage Response and Lysophagy

VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair

Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations

The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks

Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin

Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

Structure of the AAA ATPase p97

A pH-sensitive fluorescent protein sensor to follow the pathway of calcium phosphate nanoparticles into cells

Protein Phosphatase-1 Complex Disassembly by p97 is Initiated through Multivalent Recognition of Catalytic and Regulatory Subunits by the p97 SEP-domain Adapters

Regulation of lysosome integrity and lysophagy by the ubiquitin-conjugating enzyme UBE2QL1

Repair or Lysophagy : Dealing with Damaged Lysosomes

Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product Family

Structure of the PUB Domain from Ubiquitin Regulatory X Domain Protein 1 (UBXD1) and Its Interaction with the p97 AAA+ ATPase

The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage

VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle

A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases

AP-SWATH reveals direct involvement of VCP/ p97 in integrated stress response signaling through facilitating CReP/PPP1R15B degradation

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation

VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling

Delivery of the autofluorescent protein R-phycoerythrin by calcium phosphate nanoparticles into four different eukaryotic cell lines (HeLa, HEK293T, MG-63, MC3T3) : Highly efficient, but leading to endolysosomal proteolysis in HeLa and MC3T3 cells

Detection and Clearance of Damaged Lysosomes by the Endo-Lysosomal Damage Response and Lysophagy

VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

Molecular tweezers target a protein-protein interface and thereby modulate complex formation

VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair

The N-terminal region of the ubiquitin regulatory X (UBX) domain-containing protein 1 (UBXD1) modulates interdomain communication within the valosin-containing protein p97

Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1

The VCP/p97 system at a glance : connecting cellular function to disease pathogenesis

The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation

The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation

Coal mining meets chromatin research: Digging for mechanisms in epigenetic control of gene expression : Report from the 43rd Annual Meeting of the German Genetics Society on "Chromatin and Epigenetics" in Essen, Germany

The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A

Ubiquitination of the n-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPase

Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

Expanding into new markets – VCP/p97 in endocytosis and autophagy

p97 complexes as signal integration hubs

Cdc48/p97-Ufd1-Npl4 antagonizes Aurora B during chromosome segregation in HeLa cells.

Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations

The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks

A role for Cdc48/p97 and Aurora B in controlling chromatin condensation during exit from mitosis

Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation

Role(s) of Cdc48/p97 in mitosis

Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin

Detailed structural insights into the p97-Npl4-Ufd1 interface

NSF- and SNARE-mediated membrane fusion is required for nuclear envelope formation and completion of nuclear pore complex assembly in Xenopus laevis egg extracts

Structural insights into the p97-Ufd1-NpI4 complex

Golgi reassembly after mitosis : The AAA family meets the ubiquitin family

The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism

Ubiquitin Interactions of NZF Zinc Fingers

VCIP135 acts as a deubiquitinating enzyme during p97–p47-mediated reassembly of mitotic Golgi fragments

Function of the p97–Ufd1–Npl4 complex in retrotranslocation from the ER to the cytosol : dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

Structure and Ubiquitin Interactions of the Conserved Zinc Finger Domain of Npl4

The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis

Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1–Npl4

Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways

Structure of the AAA ATPase p97

The mouse p97 (CDC48) gene. Genomic structure, definition of transcriptional regulatory sequences, gene expression, and characterization of a pseudogene.

The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97