Publications
All Publications
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2024 VCP International Conference : Exploring multi-disciplinary approaches from basic science of valosin containing protein, an AAA+ ATPase protein, to the therapeutic advancement for VCP-associated multisystem proteinopathyIn: Neurobiology of Disease , Vol. 207 2025 , 106861DOI (Open Access)
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Light-Activatable Ubiquitin for Studying Linkage-Specific Ubiquitin Chain Formation KineticsIn: Advanced Science , Vol. 12 2025 , Nr. 6 , 2406570DOI (Open Access)
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Molecular Tweezers Block the Functional Pore of a Protein MachineIn: Journal of the American Chemical Society: JACS , Vol. 147 2025 , Nr. 20 , pp. 16836 - 16849DOI (Open Access)
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A modular DNA origami nanocompartment for engineering a cell-free, protein unfolding and degradation pathwayIn: Nature Nanotechnology , Vol. 19 2024 , Nr. 10 , pp. 1521 - 1531DOI (Open Access)
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Alternating binding and p97-mediated dissociation of SDS22 and I3 recycles active PP1 between holophosphatasesIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 121 2024 , Nr. 36 , e2408787121DOI (Open Access)
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Lysosomal damage sensing and lysophagy initiation by SPG20-ITCHIn: Molecular Cell 2024 , pp. 1556 - 1569.e10DOI, Online Full Text (Open Access)
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The Endo-Lysosomal Damage ResponseIn: Annual Review of Biochemistry , Vol. 93 2024 , Nr. 1 , pp. 367 - 387DOI (Open Access)
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VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substratesIn: Nature Communications , Vol. 15 2024 , Nr. 1 , 2459DOI (Open Access)
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Structural basis of ubiquitin-independent PP1 complex disassembly by p97In: The EMBO Journal , Vol. 42 2023 , Nr. 14 , e113110DOI (Open Access)
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Targeting of client proteins to the VCP/p97/Cdc48 unfolding machineIn: Frontiers in Molecular Biosciences , Vol. 10 2023 , 1142989DOI, Online Full Text (Open Access)
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The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPaseIn: Nature Communications , Vol. 14 2023 , Nr. 1 , 3258DOI, Online Full Text (Open Access)
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MAGED2 Is Required under Hypoxia for cAMP Signaling by Inhibiting MDM2-Dependent Endocytosis of G-Alpha-SIn: Cells , Vol. 11 2022 , Nr. 16 , 2546DOI (Open Access)
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Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1In: Molecular Cell , Vol. 82 2022 , Nr. 14 , pp. 2633 - 2649.e7DOI (Open Access)
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Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTNIn: The Journal of Biological Chemistry (JBC) , Vol. 298 2022 , Nr. 6 , 101976DOI (Open Access)
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)In: Autophagy , Vol. 17 2021 , Nr. 1 , pp. 1 - 382DOI (Open Access)
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Targeted substrate loop insertion by VCP/p97 during PP1 complex disassemblyIn: Nature Structural & Molecular Biology , Vol. 28 2021 , Nr. 12 , pp. 964 - 971
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A pH-sensitive fluorescent protein sensor to follow the pathway of calcium phosphate nanoparticles into cellsIn: Acta Biomaterialia , Vol. 111 2020 , pp. 406 - 417
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Protein Phosphatase-1 Complex Disassembly by p97 is Initiated through Multivalent Recognition of Catalytic and Regulatory Subunits by the p97 SEP-domain AdaptersIn: Journal of Molecular Biology (JMB) , Vol. 432 2020 , Nr. 23 , pp. 6061 - 6074
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Regulation of lysosome integrity and lysophagy by the ubiquitin-conjugating enzyme UBE2QL1In: Autophagy , Vol. 16 2020 , Nr. 1 , pp. 179 - 180DOI (Open Access)
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Repair or Lysophagy : Dealing with Damaged LysosomesIn: Journal of Molecular Biology (JMB) , Vol. 432 2020 , Nr. 1 , pp. 231 - 239
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Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product FamilyIn: Chemistry - A European Journal , Vol. 26 2020 , Nr. 39 , pp. 8524 - 8531DOI (Open Access)
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Structure of the PUB Domain from Ubiquitin Regulatory X Domain Protein 1 (UBXD1) and Its Interaction with the p97 AAA+ ATPaseIn: Biomolecules , Vol. 9 2019 , Nr. 12 , 876DOI, Online Full Text (Open Access)
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The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damageIn: EMBO Reports 2019 , pp. e48014DOI (Open Access)
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VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscleIn: Autophagy , Vol. 15 2019 , Nr. 6 , pp. 1082 - 1099DOI (Open Access)
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A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPasesIn: Angewandte Chemie International Edition , Vol. 57 2018 , Nr. 6 , pp. 1576 - 1580
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AP-SWATH reveals direct involvement of VCP/ p97 in integrated stress response signaling through facilitating CReP/PPP1R15B degradationIn: Molecular and Cellular Proteomics (MCP) , Vol. 17 2018 , Nr. 7 , pp. 1295 - 1307DOI (Open Access)
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Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme FormationIn: Molecular Cell , Vol. 72 2018 , Nr. 4 , pp. 766 - 777DOI (Open Access)
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VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and SignalingIn: Molecular Cell , Vol. 69 2018 , Nr. 2 , pp. 182 - 194DOI (Open Access)
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Delivery of the autofluorescent protein R-phycoerythrin by calcium phosphate nanoparticles into four different eukaryotic cell lines (HeLa, HEK293T, MG-63, MC3T3) : Highly efficient, but leading to endolysosomal proteolysis in HeLa and MC3T3 cellsIn: PLoS ONE , Vol. 12 2017 , Nr. 6 , pp. e0178260DOI (Open Access)
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Detection and Clearance of Damaged Lysosomes by the Endo-Lysosomal Damage Response and LysophagyIn: Current Biology , Vol. 27 2017 , Nr. 24 , pp. R1330 - R1341
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VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagyIn: The EMBO Journal , Vol. 36 2017 , Nr. 2 , pp. 135 - 150DOI (Open Access)
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Molecular tweezers target a protein-protein interface and thereby modulate complex formationIn: Chemical Communications: ChemComm , Vol. 52 2016 , Nr. 98 , pp. 14141 - 14144DOI (Open Access)
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VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break RepairIn: Molecular Cell , Vol. 64 2016 , Nr. 1 , pp. 189 - 198DOI (Open Access)
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The N-terminal region of the ubiquitin regulatory X (UBX) domain-containing protein 1 (UBXD1) modulates interdomain communication within the valosin-containing protein p97In: The Journal of Biological Chemistry (JBC) , Vol. 290 2015 , Nr. 49 , pp. 29414 - 29427DOI (Open Access)
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Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1In: The EMBO Journal , Vol. 33 2014 , Nr. 22 , pp. 2704 - 2720DOI (Open Access)
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The VCP/p97 system at a glance : connecting cellular function to disease pathogenesisIn: Journal of Cell Science , Vol. 127 2014 , Nr. 18 , pp. 3877 - 3883
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The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradationIn: The FEBS Journal , Vol. 281 2014 , Nr. Suppl. 1 , pp. 82
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The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradationIn: Cell Cycle , Vol. 13 2014 , Nr. 6 , pp. 919 - 927DOI (Open Access)
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Coal mining meets chromatin research: Digging for mechanisms in epigenetic control of gene expression : Report from the 43rd Annual Meeting of the German Genetics Society on "Chromatin and Epigenetics" in Essen, GermanyIn: BioEssays , Vol. 35 2013 , Nr. 2 , pp. 141 - 144
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The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora AIn: The Journal of Cell Biology (JCB) , Vol. 201 2013 , Nr. 4 , pp. 559 - 575
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Ubiquitination of the n-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPaseIn: The Journal of Biological Chemistry (JBC) , Vol. 288 2013 , Nr. 10 , pp. 7363 - 7372
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Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopyIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 109 2012 , pp. 1098 - 1103.DOI (Open Access)
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Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin systemIn: Nature Cell Biology , Vol. 14 2012 , Nr. 2 , pp. 117 - 123
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Expanding into new markets – VCP/p97 in endocytosis and autophagyIn: Journal of Structural Biology , Vol. 179 2012 , Nr. 2 , pp. 78 - 82
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p97 complexes as signal integration hubsIn: BMC Biology (incorporating Journal of Biology) , Vol. 10 2012 , pp. 48DOI, Online Full Text (Open Access)
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Cdc48/p97-Ufd1-Npl4 antagonizes Aurora B during chromosome segregation in HeLa cells.In: Journal of Cell Science , Vol. 124 2011 , Nr. 9 , pp. 1571 - 1580
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Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutationsIn: Nature Cell Biology , Vol. 13 2011 , Nr. 9 , pp. 1116 - 1123
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The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaksIn: Nature Cell Biology , Vol. 13 2011 , Nr. 11 , pp. 1376 - 1382
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A role for Cdc48/p97 and Aurora B in controlling chromatin condensation during exit from mitosisIn: Biochemistry and Cell Biology , Vol. 88 2010 , Nr. 1 , pp. 23 - 28
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Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradationIn: The Journal of Cell Biology (JCB) , Vol. 191 2010 , Nr. 3 , pp. 615 - 629
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Role(s) of Cdc48/p97 in mitosisIn: Biochemical Society Transactions , Vol. 36 2008 , Nr. 1 , pp. 126 - 130
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Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatinIn: Nature , Vol. 450 2007 , Nr. 7173 , pp. 1258
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Detailed structural insights into the p97-Npl4-Ufd1 interfaceIn: The Journal of Biological Chemistry (JBC) , Vol. 282 2007 , Nr. 29 , pp. 21361 - 21369
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NSF- and SNARE-mediated membrane fusion is required for nuclear envelope formation and completion of nuclear pore complex assembly in Xenopus laevis egg extractsIn: Journal of Cell Science , Vol. 120 2007 , Nr. 16 , pp. 2895 - 2903
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Structural insights into the p97-Ufd1-NpI4 complexIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Vol. 104 2007 , Nr. 2 , pp. 467 - 472
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Golgi reassembly after mitosis : The AAA family meets the ubiquitin familyIn: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research , Vol. 1744 2005 , Nr. 2 , pp. 108 - 119DOI (Open Access)
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The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanismIn: The Journal of Biological Chemistry (JBC) , Vol. 279 2004 , Nr. 48 , pp. 49609 - 49616
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Ubiquitin Interactions of NZF Zinc FingersIn: The EMBO Journal , Vol. 23 2004 , Nr. 7 , pp. 1411 - 1421
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VCIP135 acts as a deubiquitinating enzyme during p97–p47-mediated reassembly of mitotic Golgi fragmentsIn: The Journal of Cell Biology (JCB) , Vol. 164 2004 , Nr. 7 , pp. 973 - 978
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Function of the p97–Ufd1–Npl4 complex in retrotranslocation from the ER to the cytosol : dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chainsIn: The Journal of Cell Biology (JCB) , Vol. 162 2003 , Nr. 1 , pp. 71 - 84
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Structure and Ubiquitin Interactions of the Conserved Zinc Finger Domain of Npl4In: The Journal of Biological Chemistry (JBC) , Vol. 278 2003 , pp. 20225 - 20234
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The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosisIn: Cell , Vol. 115 2003 , Nr. 3 , pp. 355 - 367
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Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1–Npl4In: The EMBO Journal , Vol. 21 2002 , Nr. 21 , pp. 5645 - 5652.
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Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assemblyIn: Nature Cell Biology , Vol. 3 2001 , Nr. 12 , pp. 1086 - 1091
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The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosolIn: Nature , Vol. 414 2001 , pp. 652 - 656
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A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathwaysIn: The EMBO Journal , Vol. 19 2000 , Nr. 10 , pp. 2181 - 2192
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The mouse p97 (CDC48) gene. Genomic structure, definition of transcriptional regulatory sequences, gene expression, and characterization of a pseudogene.In: The Journal of Biological Chemistry (JBC) , Vol. 274 1999 , Nr. 15 , pp. 10154 - 10162
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The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97In: FEBS Letters , Vol. 437 1998 , Nr. 3 , pp. 255 - 257