Sven Brandau

ZMB Member
Sven Brandau

Next ZMB-Member
portrait photo of ZMB member Sven Brandau
© UKE/S.Brandau

Prof. Dr. Sven Brandau

West German Cancer Center (WTZ)
University Hospital Essen
Hufelandstr. 55
45147 Essen

Research Overview

We have a special interest in the immunological tumor-host interaction with a particular focus on neutrophils and myeloid-derived suppressor cells. A second research theme of the division aims at better understanding the immunoregulatory properties of so-called mesenchymal stromal cells. In the last ten years we have authored or co-authored over 130 peer-reviewed publications, some of which are highly cited.
Over the last ten years we have established and worked on the following three main research themes:

  1. Immunoregulatory mechanisms in tumor-host interaction
  2. Immunological and biological tumor therapy
  3. Immunobiology of mesenchymal stromal cells
Read more

Selected Publications

    Journal articles

  • Cassetta, Luca; Bruderek, Kirsten; Skrzeczynska-Moncznik, Joanna; Osiecka, Oktawia; Hu, Xiaoying; Rundgren, Ida Marie; Lin, Ang; Santegoets, Kim; Horzum, Utku; Godinho-Santos, Ana; Zelinskyy, Gennadiy; Garcia-Tellez, Thalia; Bjelica, Sunčica; Taciak, Bartłomiej; Kittang, Astrid Olsnes; Höing, Benedikt; Lang, Stephan; Dixon, Michael; Müller, Verena; Utikal, Jochen Sven; Karakoç, Derya; Yilmaz, Kerim Bora; Górka, Emilia; Bodnar, Lubomir; Anastasiou, Olympia Evdoxia; Bourgeois, Christine; Badura, Robert; Kapinska-Mrowiecka, Monika; Gotic, Mirjana; Ter Laan, Mark; Kers-Rebel, Esther; Król, Magdalena; Santibañez, Juan Francisco; Müller-Trutwin, Michaela; Dittmer, Ulf; De Sousa, Ana Espada; Esendaǧli, Güneş; Adema, Gosse; Loré, Karin; Ersvær, Elisabeth; Umansky, Viktor; Pollard, Jeffrey W.; Cichy, Joanna; Brandau, Sven
    Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation
    In: Journal for ImmunoTherapy of Cancer Vol. 8 (2020) Nr. 2, pp. e001223
    ISSN: 2051-1426
  • Si, Yu; Merz, Simon F.; Jansen, Philipp; Wang, Baoxiao; Bruderek, Kirsten; Altenhoff, Petra; Mattheis, Stefan; Lang, Stephan; Gunzer, Matthias; Klode, Joachim; Squire, Anthony; Brandau, Sven
    Multidimensional imaging provides evidence for down-regulation of T cell effector function by MDSC in human cancer tissue
    In: Science Immunology Vol. 4 (2019) Nr. 40,
    ISSN: 2470-9468
  • Lang, Stephan; Bruderek, Kirsten; Kaspar, Cordelia; Höing, Benedikt; Kanaan, Oliver; Dominas, Nina; Hussain, Timon; Droege, Freya; Eyth, Christian; Hadaschik, Boris; Brandau, Sven
    Clinical Relevance and Suppressive Capacity of Human Myeloid-Derived Suppressor Cell Subsets
    In: Clinical Cancer Research Vol. 24 (2018) Nr. 19, pp. 4834 - 4844
    ISSN: 1078-0432; 1557-3265
  • Klein, Johanna C.; Moses, Katrin; Zelinskyy, Gennadiy; Sody, Simon; Buer, Jan; Lang, Stephan; Helfrich, Iris; Dittmer, Ulf; Kirschning, Carsten Jürgen; Brandau, Sven
    Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth
    In: Nature Communications Vol. 8 (2017) pp. 14600
    ISSN: 2041-1723
  • Brandau, Sven; Hartl, Dominik
    Lost in neutrophil heterogeneity? : CD10!
    In: Blood Vol. 129 (2017) Nr. 10, pp. 1240 - 1241
    ISSN: 0006-4971; 1528-0020
  • Kansy, Benjamin A.; Concha-Benavente, Fernando; Srivastava, Raghvendra M.; Jie, Hyun-Bae; Shayan, Gulidanna; Lei, Yu; Moskovitz, Jessica; Moy, Jennifer; Li, Jing; Brandau, Sven; Lang, Stephan; Schmitt, Nicole C.; Freeman, Gordon J.; Gooding, William E.; Clump, David A.; Ferris, Robert L.
    PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer
    In: Cancer Research Vol. 77 (2017) Nr. 22, pp. 6353 - 6364
    ISSN: 0008-5472
  • Kalkavan, Halime; Sharma, Piyush; Kasper, Stefan; Helfrich, Iris; Pandyra, Aleksandra A.; Gassa, Asmae; Virchow, Isabel; Flatz, Lukas; Brandenburg, Tim; Namineni, Sukumar; Heikenwalder, Mathias; Höchst, Bastian; Knolle, Percy A.; Wollmann, Guido; Von Laer, Dorothee; Drexler, Ingo; Rathbun, Jessica; Cannon, Paula M.; Scheu, Stefanie; Bauer, Jens; Chauhan, Jagat; Häussinger, Dieter; Willimsky, Gerald; Löhning, Max; Schadendorf, Dirk; Brandau, Sven; Schuler, Martin; Lang, Philipp A.; Lang, Karl S.
    Spatiotemporally restricted arenavirus replication induces immune surveillance and type i interferon-dependent tumour regression
    In: Nature Communications Vol. 8 (2017) pp. 14447
    ISSN: 2041-1723
  • Bronte, Vincenzo; Brandau, Sven; Chen, Shu-Hsia; Colombo, Mario P; Frey, Alan B; Greten, Tim F; Mandruzzato, Susanna; Murray, Peter J; Ochoa, Augusto; Ostrand-Rosenberg, Suzanne; Rodriguez, Paulo C; Sica, Antonio; Umansky, Viktor; Vonderheide, Robert H; Gabrilovich, Dmitry I
    Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
    In: Nature Communications Vol. 7 (2016) pp. 12150
    ISSN: 2041-1723
  • Hasenberg, Anja; Hasenberg, Mike; Männ, Linda; Neumann, Franziska; Borkenstein, Lars; Stecher, Manuel; Kraus, Andreas; Engel, Daniel Robert; Klingberg, Anika; Seddigh, Pegah; Abdullah, Zeinab; Klebow, Sabrina; Engelmann, Swen; Reinhold, Annegret; Brandau, Sven; Seeling, Michaela; Waisman, Ari; Schraven, Burkhart; Göthert, Joachim Rudolf; Nimmerjahn, Falk; Gunzer, Matthias
    Catchup : a mouse model for imaging-based tracking and modulation of neutrophil granulocytes
    In: Nature Methods Vol. 12 (2015) Nr. 5, pp. 445 - 452
    ISSN: 1548-7091; 1548-7105
  • Schuler, Martin; Breitenbücher, Frank; Trarbach, Tanja; Brandau, Sven; Schmid, Kurt Werner; Kasper, Stefan
    Simultaneous protection against anti-EGFR antibody-dependent cellular cytotoxicity and EGFR-signaling blockade by oncogenic RAS
    In: Journal of Clinical Oncology Vol. 29 (2011) Nr. Suppl. 4, pp. 440
    ISSN: 0732-183X; 1527-7755