ZMB member Björn Scheffler

ZMB Member
Björn Scheffler

Next ZMB-Member
Björn Scheffler
© Scheffler/Lange/punktbar

Prof. Dr. Björn Scheffler

Group

Translational Neurooncology

West German Cancer Center (WTZ)
German Cancer Research Center (DKFZ)
University Duisburg-Essen
45141 Essen

Research Overview

We are an extramural Division of the German Cancer Research Center (DKFZ) in Heidelberg, set up as part of the German Cancer Consortium (DKTK) at the West German Cancer Center (WTZ) in Essen. The lab employs clinician scientists, medical scientists, students pursuing medical or biomedical degree programs, technicians and administrative staff. We conduct basic research in such a way that clinical applications for cancer therapy can be translated to patients as soon as possible. Most of our Wetlab protocols apply stem cell biology tools and patient-derived cancer cells. Current studies focus on

  1. phenotypic plasticity of treatment-resistant cancer cells
  2. the role of the immune system in the progression of cancer
  3. the development of new anticancer therapeutics
  4. establishing new biomarkers for predicting the clinical course of cancer and its response to therapy in early-phase clinical studies.

We primarily study oncogenic mechanisms related to human brain tumors and metastasized CNS disease; however, our translational approach enables validation of discoveries in any type of cancer. The research is interdisciplinary and is carried out in close collaboration with all clinical units providing neuro-oncology services at the University Hospital Essen and with many national and international collaborators from academia and industry.

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Selected Publications

    Journal articles

  • Kebir, Sied; Ullrich, Vivien; Berger, Pia; Dobersalske, Celia; Langer, Sarah; Rauschenbach, Laurèl; Trageser, Daniel; Till, Andreas; Lorbeer, Franziska K.; Wieland, Anja; Wilhelm-Buchstab, Timo; Ahmad, Ashar; Fröhlich, Holger; Cima, Igor; Prasad, Shruthi; Matschke, Johann; Jendrossek, Verena; Remke, Marc; Grüner, Barbara M.; Rösch, Alexander; Siveke, Jens; Herold-Mende, Christel; Blau, Tobias; Keyvani, Kathy; van Landeghem, Frank K H; Pietsch, Torsten; Felsberg, Jörg; Reifenberger, Guido; Weller, Michael; Sure, Ulrich; Brüstle, Oliver; Simon, Matthias; Glas, Martin; Scheffler, Björn
    A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma
    In: Clinical Cancer Research Vol. 29 (2023) Nr. 2, pp. 488 - 500
    ISSN: 1557-3265; 1078-0432
    Online Full Text: dx.doi.org/ (Open Access)
  • Ratliff, Miriam; Karimian-Jazi, Kianush; Hoffmann, Dirk C; Rauschenbach, Laurèl; Simon, Matthias; Hai, Ling; Mandelbaum, Henriette; Schubert, Marc C; Kessler, Tobias; Uhlig, Stefanie; Dominguez Azorin, Daniel; Jung, Erik; Osswald, Matthias; Solecki, Gergely; Maros, Máté E; Venkataramani, Varun; Glas, Martin; Etminan, Nima; Scheffler, Björn; Wick, Wolfgang; Winkler, Frank
    Individual glioblastoma cells harbor both proliferative and invasive capabilities during tumor progression
    In: Neuro-Oncology (2023) in press
    ISSN: 1522-8517; 1523-5866
    Online Full Text: dx.doi.org/
  • Cheung, Phyllis F.; Yang, JiaJin; Fang, Rui; Borgers, Arianna; Krengel, Kirsten; Stoffel, Anne; Althoff, Kristina; Yip, Chi Wai; Siu, Elaine H. L.; Ng, Linda W. C.; Lang, Karl S.; Cham, Lamin B.; Engel, Daniel Robert; Soun, Camille; Cima, Igor; Scheffler, Björn; Striefler, Jana K.; Sinn, Marianne; Bahra, Marcus; Pelzer, Uwe; Oettle, Helmut; Markus, Peter; Smeets, Esther M. M.; Aarntzen, Erik H. J. G.; Savvatakis, Konstantinos; Liffers, Sven-Thorsten; Lueong, Smiths S.; Neander, Christian; Bazarna, Anna; Zhang, Xin; Paschen, Annette; Crawford, Howard C.; Chan, Anthony W. H.; Cheung, Siu Tim; Siveke, Jens
    Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression
    In: Nature Communications Vol. 13 (2022) Nr. 1,
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Bartl, Jasmin; Zanini, Marco; Bernardi, Flavia; Forget, Antoine; Blümel, Lena; Talbot, Julie; Picard, Daniel; Qin, Nan; Cancila, Gabriele; Gao, Qingsong; Nath, Soumav; Koumba, Idriss Mahoungou; Wolter, Marietta; Kuonen, François; Langini, Maike; Beez, Thomas; Munoz, Christopher; Pauck, David; Marquardt, Viktoria; Yu, Hua; Souphron, Judith; Korsch, Mascha; Mölders, Christina; Berger, Daniel; Göbbels, Sarah; Meyer, Frauke-Dorothee; Scheffler, Björn; Rotblat, Barak; Diederichs, Sven; Ramaswamy, Vijay; Suzuki, Hiromishi; Oro, Anthony; Stühler, Kai; Stefanski, Anja; Fischer, Ute; Leprivier, Gabriel; Willbold, Dieter; Steger, Gerhard; Buell, Alexander; Kool, Marcel; Lichter, Peter; Pfister, Stefan M.; Northcott, Paul A.; Taylor, Michael D.; Borkhardt, Arndt; Reifenberger, Guido; Ayrault, Olivier; Remke, Marc
    The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors
    In: Nature Communications Vol. 13 (2022) Nr. 1,
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Lu, I-Na; Dobersalske, Celia; Rauschenbach, Laurèl; Teuber-Hanselmann, Sarah; Steinbach, Anita; Ullrich, Vivien; Prasad, Shruthi; Blau, Tobias; Kebir, Sied; Siveke, Jens; Becker, Jürgen; Sure, Ulrich; Glas, Martin; Scheffler, Björn; Cima, Igor
    Tumor-associated hematopoietic stem and progenitor cells positively linked to glioblastoma progression
    In: Nature Communications Vol. 12 (2021) Nr. 1,
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Sood, Disha; Tang-Schomer, Min; Pouli, Dimitra; Mizzoni, Craig; Raia, Nicole; Tai, Albert; Arkun, Knarik; Wu, Julian; Black, Lauren D.; Scheffler, Björn; Georgakoudi, Irene; Steindler, Dennis A.; Kaplan, David L.
    3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors
    In: Nature Communications Vol. 10 (2019) pp. 4529
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Shannan, B.; Matschke, Johann; Chauvistré, Heike; Vogel, F.; Klein, Diana; Meier, Friedegund; Westphal, Dana; Bruns, Johannes; Rauschenberg, Ricarda; Utikal, Jochen; Forschner, Andrea; Berking, Carola; Terheyden, Patrick; Dabrowski, Evelyn; Gutzmer, Ralf; Rafei-Shamsabadi, David Ali; Meiss, Frank; Heinzerling, Lucie M.; Zimmer, Lisa; Livingstone, Elisabeth; Váraljai, Renáta; Hoewner, A.; Horn, Susanne; Klode, Joachim; Stuschke, Martin; Scheffler, Björn; Marchetto, Aruna; Sannino, Giuseppina; Grünewald, Thomas Georg Philipp; Schadendorf, Dirk; Jendrossek, Verena; Rösch, Alexander
    Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV⁶⁰⁰E inhibition in melanoma
    In: European Journal of Cancer Vol. 109 (2019) pp. 137 - 153
    ISSN: 1879-0852; 0959-8049
    Online Full Text: dx.doi.org/
  • Reinartz, Roman; Wang, Shanshan; Kebir, Sied; Silver, Daniel J.; Wieland, Anja; Zheng, Tong; Kupper, Marius; Rauschenbach, Laurel; Fimmers, Rolf; Shepherd, Timothy M.; Trageser, Daniel; Till, Andreas; Schafer, Niklas; Glas, Martin; Hillmer, Axel M.; Cichon, Sven; Smith, Amy A.; Pietsch, Torsten; Liu, Ying; Reynolds, Brent A.; Yachnis, Anthony; Pincus, David W.; Simon, Matthias; Brustle, Oliver; Steindler, Dennis A.; Scheffler, Björn
    Functional Subclone profiling for prediction of treatment-induced intratumor population shifts and discovery of rational drug combinations in human glioblastoma
    In: Clinical Cancer Research Vol. 23 (2017) Nr. 2, pp. 562 - 574
    ISSN: 1557-3265; 1078-0432
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Kebir, Sied; Rauschenbach, Laurèl; Galldiks, Norbert; Schlaak, Max; Hattingen, Elke; Landsberg, Jennifer; Bundschuh, Ralph A.; Langen, Karl-Josef; Scheffler, Björn; Herrlinger, Ulrich; Glas, Martin
    Dynamic O-(2-[18F]fluoroethyl)-L-tyrosine PET imaging for the detection of checkpoint inhibitor-related pseudoprogression in melanoma brain metastases
    In: Neuro-Oncology Vol. 18 (2016) Nr. 10, pp. 1462 - 1464
    ISSN: 1522-8517; 1523-5866
    Online Full Text: dx.doi.org/
  • Wieland, Anja; Trageser, Daniel; Gogolok, Sabine; Reinartz, Roman; Höfer, Heike; Keller, Mihaela; Leinhaas, Anke; Schelle, Ramona; Normann, Sabine; Klaas, Lil; Waha, Andreas; Koch, Philipp; Fimmers, Rolf; Pietsch, Torsten; Yachnis, Anthony T.; Pincus, David W.; Steindler, Dennis A.; Brüstle, Oliver; Simon, Matthias; Glas, Martin; Scheffler, Björn
    Anticancer effects of niclosamide in human glioblastoma
    In: Clinical Cancer Research Vol. 19 (2013) Nr. 15, pp. 4124 - 4136
    ISSN: 1557-3265; 1078-0432
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Li, Yunqing; Li, Angela; Glas, Martin; Lal, Bachchu; Ying, Mingyao; Sang, Yingying; Xia, Shuli; Trageser, Daniel; Guerrero-Cázares, Hugo; Eberhart, Charles G.; Quiñones-Hinojosa, Alfredo; Scheffler, Björn; Laterra, John
    c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 108 (2011) Nr. 24, pp. 9951 - 9956
    ISSN: 1091-6490; 1091-6490
    Online Full Text: dx.doi.org/ (Open Access)
  • Glas, Martin; Rath, Barbara H.; Simon, Matthias; Reinartz, Roman; Schramme, Anja; Trageser, Daniel; Eisenreich, Ramona; Leinhaas, Anke; Keller, Mihaela; Schildhaus, Hans-Ulrich; Garbe, Stephan; Steinfarz, Barbara; Pietsch, Torsten; Steindler, Dennis A.; Schramm, Johannes; Herrlinger, Ulrich; Brüstle, Oliver; Scheffler, Björn
    Residual tumor cells are unique cellular targets in glioblastoma
    In: Annals of Neurology Vol. 68 (2010) Nr. 2, pp. 264 - 269
    ISSN: 1531-8249; 0364-5134
    Online Full Text: dx.doi.org/ (Open Access)
  • Goetz, A. Katrin; Scheffler, Björn; Chen, Huan-Xin; Wang, Shanshan; Suslov, Oleg; Xiang, Hui; Brüstle, Oliver; Roper, Steve N.; Steindler, Dennis A.; Chen, H.-X.
    Temporally restricted substrate interactions direct fate and specification of neural precursors derived from embryonic stem cells
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 103 (2006) Nr. 29, pp. 11063 - 11068
    ISSN: 1091-6490
    Online Full Text: dx.doi.org/ (Open Access)
  • Benninger, Felix; Beck, Heinz; Wernig, Marius; Tucker, Kerry L.; Brüstle, Oliver; Scheffler, Björn
    Functional integration of embryonic stem cell-derived neurons in hippocampal slice cultures
    In: Journal of Neuroscience Vol. 23 (2003) Nr. 18, pp. 7075 - 7083
    ISSN: 1529-2401
    Online Full Text: dx.doi.org/ (Open Access)
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