ZMB Member Alexander Roesch

ZMB Member
Alexander Roesch

Next ZMB-Member
Alexander Roesch portrait
© UKE/Roesch

Prof. Dr. Alexander Roesch

Clinic for Dermatology
University Hospital Essen
Hufelandstraße 55
45147 Essen

Research Overview

Melanoma is an aggressive tumor with dramatically reduced patient survival when disseminated to distant organs. Despite the historic success of modern cancer drugs, the cure of patients is hampered by the notorious tumor heterogeneity and plasticity of melanoma leading to therapy failure in most cases and limited diagnostic options to monitor therapy response/resistance over time.

Alexander Roesch research image
© Alexander Roesch

Recent work and topics

Alexander Roesch research image
© Alexander Roesch

Tumor cell state switching & Therapy resistance in melanoma
Accumulating evidence indicates that therapy and immune escape in cancer is not solely driven by genetic evolution, but also by the epigenetic adaptive plasticity of cell phenotypes. Current findings by us and others point to an understanding of melanoma as a highly plastic system, in which tumor cell subpopulations dynamically switch between multiple cellular identities (e.g. differentiated vs. de-differentiated, OXPHOS-driven vs. glycolytic, high vs. low ROS detoxifying, etc.) depending on the current therapeutic and microenvironmental context. As initiator and consortial member of the Clinical Research Unit CRU/KFO 337 (PhenoTImE), we are using established and patient-derived cell systems to study and track tumor cell states across different cancer entities in the context of signaling-targeted and immune checkpoint therapies. Technology-wise, our group applies for example cell state-directed fluorescent reporter constructs, multiplexed CODEX™ imaging, mass-spectrometry imaging, mass-spectrometric metabolomics, and, for cell manipulation, CRISPR/Cas9 editing and chemical compound libraries. Alexander Roesch research image
Dynamic therapy and immune escape. While the majority of cancer cells can be eliminated by first-line therapies and immune cell activation, a small portion of the tumor survives (minimal residual disease) and gives rise to clinical tumor relapse. The pre-resistant persister pool (DTP cells, dashed box) comprises a complex reservoir of different cell states from which repopulation of tumor heterogeneity dynamically emerges.
© Alexander Roesch

Regulation of tumor cell fate decisions
The phenotypic capacity to reversibly switch between different cell states provides a fundamental advantage for tumors to survive selective pressure. Our group has focused on the preclinical and clinical description of melanoma persister cell states over the past years. We have shown that melanomas irrespective of their genetic heterogeneity comprise multi-drug resistant, non-proliferating cells that repopulate the tumor and are identified by high expression of the histone H3K4 demethylase KDM5B (JARID1B). However, the exact role of KDM5B for regulating cellular identity and ways to exploit it for biomedical applications are still unclear; especially since the expression of KDM5B does not follow a static hierarchy, but is dynamically changing depending on the therapeutic con-text. Specifically, we hypothesize that KDM5B is a dynamic molecular switch that interconnects cell differentiation and cell cycle control. A deeper understanding of the switches between KDM5B levels and how this triggers transitions in cell states could lead to novel drugs with significant improvement in cancer treatment.

Alexander Roesch research image
Dynamic cell fate decisions. Melanoma cells can dynamically shift between different differentiation, metabolic, and cell cycle states depending on the expression level of KDM5B/JARID1B.
© Alexander Roesch

Liquid biopsy and Tumor monitoring
Personalized oncology has not managed yet to overcome the limitation by inter- and intra-tumor heterogeneity in patients. This dilemma is even further complicated by the limited real-time information that translational research in humans but also in common mouse models can provide due to the high invasiveness of its mostly tissue biopsy-based design. In contrast, liquid biopsies, comprising the noninvasive analysis of circulating tumor-derived material in the blood, represent an innovative tool in precision oncology to overcome current limitations associated with tissue biopsies; however, mostly unspecific markers are used for the sole assessment of tumor load so far, while biology-specific read-outs are not yet implemented. As part of the EU Horizon 2020 Marie Curie Training Program MELGEN and an active member of the European Liquid Biopsy Society (ELBS), we have established a multi-analyte, multi-marker liquid biopsy platform for diagnostic and therapy monitoring application. The goal of our LB projects is to develop a multilateral liquid biopsy platform that allows tumor load monitoring and assessment of tumor biological processes, such as phenotype switching, in melanoma patients and mouse models. Alexander Roesch research image
ctDNA-based serial monitoring for early prediction of therapy outcome. Serial monitoring of mutant ctDNA copies under therapy predicts clinical progression earlier as compared to routine radiologic scans
© Alexander Roesch

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    Journal articles

  • Liu, Wei; Stachura, Paweł; Xu, Haifeng C.; Váraljai, Renáta; Shinde, Prashant; Ganesh, Nikkitha Umesh; Mack, Matthias; Van Lierop, Anke; Huang, Anfei; Sundaram, Balamurugan; Lang, Karl S.; Picard, Daniel; Fischer, Ute; Remke, Marc; Homey, Bernhard; Rösch, Alexander; Häussinger, Dieter; Lang, Philipp A.; Borkhardt, Arndt; Pandyra, Aleksandra A.; Stachura, Pawel; Umesh Ganesh, Nikkitha
    BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment
    In: Cancer Research Vol. 82 (2022) Nr. 2, pp. 264 - 277
    ISSN: 1538-7445; 0099-7374
  • Jansen, Philipp; Lodde, Georg; Wetter, Axel; Welt, Anja; Stuschke, Martin; Dührsen, U.; Stoffels, Ingo; Klode, Joachim; Livingstone, Elisabeth; Zimmer, Lisa; Rösch, Alexander; Hadaschik, Eva; Griewank, Klaus; Schadendorf, Dirk; Ugurel, Selma
    Checkpoint immunotherapy of cutaneous squamous cell carcinoma in patients suffering from chronic lymphocytic leukaemia : divergent outcomes in two men treated with PD-1 inhibitors
    In: Journal of the European Academy of Dermatology and Venereology Vol. 36 (2022) Nr. S1: Anti PD-1 Therapy of Advanced Cutaneous Squamous Cell Carcinoma, pp. 41 - 44
    ISSN: 0926-9959; 1468-3083
  • Franklin, Cindy; Mohr, Peter; Bluhm, Leonie; Grimmelmann, Imke; Gutzmer, Ralf; Meier, Friedegund; Garzarolli, Marlene; Weichenthal, Michael; Pfoehler, Claudia; Herbst, Rudolf; Terheyden, Patrick; Utikal, Jochen; Ulrich, Jens; Debus, Dirk; Haferkamp, Sebastian; Kaatz, Martin; Forschner, Andrea; Leiter, Ulrike; Nashan, Dorothee; Kreuter, Alexander; Sachse, Michael; Welzel, Julia; Heinzerling, Lucie; Meiss, Frank; Weishaupt, Carsten; Gambichler, Thilo; Weyandt, Gerhard; Dippel, Edgar; Schatton, Kerstin; Celik, Eren; Trommer, Maike; Helfrich, Iris; Rösch, Alexander; Zimmer, Lisa; Livingstone, Elisabeth; Schadendorf, Dirk; Horn, Susanne; Ugurel, Selma
    Impact of radiotherapy and sequencing of systemic therapy on survival outcomes in melanoma patients with previously untreated brain metastasis : a multicenter DeCOG study on 450 patients from the prospective skin cancer registry ADOREG
    In: Journal for ImmunoTherapy of Cancer Vol. 10 (2022) Nr. 6,
    ISSN: 2051-1426
  • Jansen, Philipp; Lodde, Georg; Griewank, Klaus; Hadaschik, Eva; Rösch, Alexander; Ugurel, Selma; Zimmer, Lisa; Livingstone, Elisabeth; Schadendorf, Dirk
    Management of partial and non-responding cutaneous squamous cell carcinoma
    In: Journal of the European Academy of Dermatology and Venereology Vol. 36 (2022) Nr. S1, pp. 29 - 34
    ISSN: 0926-9959; 1468-3083
  • Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Jürgen; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodríguez-López, José Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Rösch, Alexander
    Persister state-directed transitioning and vulnerability in melanoma
    In: Nature Communications Vol. 13 (2022) Nr. 1,
    ISSN: 2041-1723
  • Placke, Jan-Malte; Rawitzer, Josefine; Reis, Henning; Rashidi-Alavijeh, Jassin; Livingstone, Elisabeth; Ugurel, Selma; Hadaschik, Eva; Griewank, Klaus; Schmid, Kurt Werner; Schadendorf, Dirk; Rösch, Alexander; Zimmer, Lisa
    Apoptotic Gastritis in Melanoma Patients Treated With PD-1-Based Immune Checkpoint Inhibition : Clinical and Histopathological Findings Including the Diagnostic Value of Anti-Caspase-3 Immunohistochemistry
    In: Frontiers in Oncology Vol. 11 (2021)
    ISSN: 2234-943X
  • Zaremba, Anne; Philip, Manuel; Hassel, Jessica C.; Glutsch, Valerie; Fiocco, Zeno; Loquai, Carmen; Rafei-Shamsabadi, David; Gutzmer, Ralf; Utikal, Jochen; Haferkamp, Sebastian; Reinhardt, Lydia; Kähler, Katharina C.; Weishaupt, Carsten; Moreira, Alvaro; Thoms, Kai-Martin; Wilhelm, Tabea; Pföhler, Claudia; Rösch, Alexander; Ugurel, Selma; Zimmer, Lisa; Stadtler, Nadine; Sucker, Antje; Kiecker, Felix; Heinzerling, Lucie; Meier, Friedegund; Meiss, Frank; Schlaak, Max; Schilling, Bastian; Horn, Susanne; Schadendorf, Dirk; Livingstone, Elisabeth
    Clinical characteristics and therapy response in unresectable melanoma patients stage IIIB-IIID with in-transit and satellite metastases
    In: European Journal of Cancer (EJC) Vol. 152 (2021) pp. 139 - 154
    ISSN: 1879-0852; 0959-8049
  • Placke, Jan-Malte; Reis, Henning; Hadaschik, Eva; Rösch, Alexander; Schadendorf, Dirk; Stoffels, Ingo; Klode, Joachim
    Coronavirus disease 2019 vaccine mimics lymph node metastases in patients undergoing skin cancer follow-up : A monocentre study
    In: European Journal of Cancer Vol. 154 (2021) pp. 167 - 174
    ISSN: 1879-0852; 0959-8049
  • Placke, Jan-Malte; Soun, Camille; Bottek, Jenny; Herbst, Rudolf; Terheyden, Patrick; Utikal, Jochen; Pföhler, Claudia; Ulrich, Jens; Kreuter, Alexander; Pfeiffer, Christiane; Mohr, Peter; Gutzmer, Ralf; Meier, Friedegund; Dippel, Edgar; Weichenthal, Michael; Zimmer, Lisa; Livingstone, Elisabeth; Becker, Jürgen; Lodde, Georg; Sucker, Antje; Griewank, Klaus; Horn, Susanne; Hadaschik, Eva; Rösch, Alexander; Schadendorf, Dirk; Engel, Daniel Robert; Ugurel, Selma
    Digital Quantification of Tumor PD-L1 Predicts Outcome of PD-1-Based Immune Checkpoint Therapy in Metastatic Melanoma
    In: Frontiers in Oncology Vol. 11 (2021)
    ISSN: 2234-943X
  • Lodde, Georg; Forschner, Andrea; Hassel, Jessica; Wulfken, Lena M.; Meier, Friedegund; Mohr, Peter; Kähler, Katharina; Schilling, Bastian; Loquai, Carmen; Berking, Carola; Hüning, Svea; Schatton, Kerstin; Gebhardt, Christoffer; Eckardt, Julia; Gutzmer, Ralf; Reinhardt, Lydia; Glutsch, Valerie; Nikfarjam, Ulrike; Erdmann, Michael; Stang, Andreas; Kowall, Bernd; Rösch, Alexander; Ugurel, Selma; Zimmer, Lisa; Schadendorf, Dirk; Livingstone, Elisabeth
    Factors influencing the adjuvant therapy decision : Results of a real-world multicenter data analysis of 904 melanoma patients
    In: Cancers Vol. 13 (2021) Nr. 10, pp. 2319
    ISSN: 2072-6694
  • Váraljai, Renáta; Horn, Susanne; Sucker, Antje; Pierscianek, Daniela; Schmitt, Verena; Carpinteiro, Alexander; Becker, Katrin; Reifenberger, Julia; Rösch, Alexander; Felsberg, Joerg; Reifenberger, Guido; Sure, Ulrich; Schadendorf, Dirk; Helfrich, Iris
    Integrative genomic analyses of patient-matched intracranial and extracranial metastases reveal a novel brain-specific landscape of genetic variants in driver genes of malignant melanoma
    In: Cancers Vol. 13 (2021) Nr. 4, pp. 731
    ISSN: 2072-6694
  • Chorti, Eleftheria; Kebir, Sied; Ahmed, Misbah S.; Keyvani, Kathy; Umutlu, Lale; Kanaki, Theodora; Zaremba, Anne; Reinboldt-Jockenhöfer, Finja; Knispel, Sarah; Gratsias, Emmanouil; Rösch, Alexander; Ugurel, Selma; Scheffler, Björn; Schadendorf, Dirk; Livingstone, Elisabeth; Meier, Friedegund; Glas, Martin; Zimmer, Lisa
    Leptomeningeal disease from melanoma : Poor prognosis despite new therapeutic modalities
    In: European Journal of Cancer (EJC) Vol. 148 (2021) pp. 395 - 404
    ISSN: 1879-0852; 0959-8049; 1879-2995
  • Harbers, Franziska Noelle; Thier, Beatrice; Stupia, Simone; Zhu, Si; Schwamborn, Marion; Peller, Vicky; Chauvistré, Heike; Crivello, Pietro; Fleischhauer, Katharina; Rösch, Alexander; Sucker, Antje; Schadendorf, Dirk; Chen, Yong; Paschen, Annette; Zhao, Fang
    Melanoma Differentiation Trajectories Determine Sensitivity Toward Pre-Existing CD8⁺ Tumor-Infiltrating Lymphocytes
    In: Journal of Investigative Dermatology Vol. 141 (2021) Nr. 10, pp. 2480 - 2489
    ISSN: 1523-1747; 0022-202X
  • Brase, Jan C.; Walter, Robert F.H.; Savchenko, Alexander; Gusenleitner, Daniel; Garrett, James; Schimming, Tobias; Varaljai, Renata; Castelletti, Deborah; Kim, Ju; Dakappagari, Naveen; Schultz, Ken; Robert, Caroline; Long, Georgina V.; Nathan, Paul D.; Ribas, Antoni; Flaherty, Keith T.; Karaszewska, Boguslawa; Schachter, Jacob; Sucker, Antje; Schmid, Kurt Werner; Zimmer, Lisa; Livingstone, Elisabeth; Gasal, Eduard; Schadendorf, Dirk; Rösch, Alexander
    Role of Tumor-Infiltrating B Cells in Clinical Outcome of Patients with Melanoma Treated With Dabrafenib Plus Trametinib
    In: Clinical Cancer Research Vol. 27 (2021) Nr. 16, pp. 4500 - 4510
    ISSN: 1557-3265; 1078-0432
  • Váraljai, Renáta; Elouali, S.; Lueong, Smiths S.; Wistuba-Hamprecht, Kilian; Seremet, Teofila C.; Siveke, Jens; Becker, Jürgen; Sucker, Antje; Paschen, Annette; Horn, Peter; Neyns, Bart; Weide, Benjamin M.; Schadendorf, Dirk; Rösch, Alexander
    The predictive and prognostic significance of cell-free DNA concentration in melanoma
    In: Journal of the European Academy of Dermatology and Venereology Vol. 35 (2021) Nr. 2, pp. 387 - 395
    ISSN: 0926-9959; 1468-3083
  • Zimmer, Lisa; Livingstone, Elisabeth; Hassel, Jessica C.; Fluck, Michael; Eigentler, Thomas; Loquai, Carmen; Haferkamp, Sebastian; Gutzmer, Ralf; Meier, Friedegund; Mohr, Peter; Hauschild, Axel; Schilling, Bastian; Menzer, Christian; Kieker, Felix; Dippel, Edgar; Rösch, Alexander; Simon, Jan-Christoph; Conrad, Beate; Körner, Silvia; Windemuth-Kieselbach, Christine; Schwarz, Leonora; Garbe, Claus; Becker, Jürgen C.; Schadendorf, Dirk; Berking, Carola; Herbst, Rudolf A.; Martens, Uwe M; Sell, Sabine; Stadler, Rudolf; Terheyden, Patrick; Utikal, Jochen
    Adjuvant nivolumab plus ipilimumab or nivolumab monotherapy versus placebo in patients with resected stage IV melanoma with no evidence of disease (IMMUNED) : a randomised, double-blind, placebo-controlled, phase 2 trial
    In: The Lancet Vol. 395 (2020) Nr. 10236, pp. 1558 - 1568
    ISSN: 1474-547X; 0140-6736
  • Chorti, Eleftheria; Kanaki, Theodora; Zimmer, Lisa; Hadaschik, Eva; Ugurel, Selma; Gratsias, Emmanouil; Rösch, Alexander; Bonella, Francesco; Wessendorf, Thomas; Wälscher, Julia; Theegarten, Dirk; Schadendorf, Dirk; Livingstone, Elisabeth
    Drug-induced sarcoidosis-like reaction in adjuvant immunotherapy : Increased rate and mimicker of metastasis
    In: European Journal of Cancer Vol. 131 (2020) pp. 18 - 26
    ISSN: 1879-0852; 0959-8049
  • Koch, F.; Salva, Katrin Agnes; Wirtz, M.; Hadaschik, Eva; Varaljai, Renáta; Schadendorf, Dirk; Rösch, Alexander
    Efficacy of cold atmospheric plasma vs. diclofenac 3% gel in patients with actinic keratoses : A prospective, randomized and rater-blinded study (ACTICAP)
    In: Journal of the European Academy of Dermatology and Venereology Vol. 34 (2020) Nr. 12, pp. E844 - E846
    ISSN: 1468-3083; 0926-9959
  • Zaremba, Anne; Zimmer, Lisa; Chorti, Eleftheria; Reissig, Timm M.; Bauer, Sebastian; Podleska, Lars; Schulz, Andrea; Hadaschik, Eva; Griewank, Klaus; Rösch, Alexander; Schadendorf, Dirk; Livingstone, Elisabeth
    Fatal swelling of the groin – Clear cell sarcoma : A rare but important differential diagnosis to malignant melanoma
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Vol. 18 (2020) Nr. 10, pp. 1165 - 1168
    ISSN: 1610-0387; 1563-2571; 1610-0379; 0301-0481
  • Zaremba, Anne; Zimmer, Lisa; Griewank, Klaus; Ugurel, Selma; Rösch, Alexander; Schadendorf, Dirk; Livingstone, Elisabeth
    Immuntherapie beim malignen Melanom
    In: Der Internist Vol. 61 (2020) Nr. 7, pp. 669 - 675
    ISSN: 1432-1289; 0020-9554
  • Zaremba, Anne; Zimmer, Lisa; Griewank, Klaus; Ugurel, Selma; Rösch, Alexander; Schadendorf, Dirk; Livingstone, Elisabeth
    Malignes Melanom : Stellenwert der BRAF-Inhibition beim malignen Melanom
    In: Der Onkologe Vol. 26 (2020) Nr. 8, pp. 713 - 720
    ISSN: 1433-0415; 0947-8965
  • Metzenmacher, Martin; Váraljai, Renáta; Hegedüs, Balazs; Cima, Igor; Forster, Jan; Schramm, Alexander; Scheffler, Björn; Horn, Peter; Klein, Christoph A.; Szarvas, Tibor; Reis, Henning; Bielefeld, Nicola; Rösch, Alexander; Aigner, Clemens; Kunzmann, Volker; Wiesweg, Marcel; Siveke, Jens; Schuler, Martin; Lueong, Smiths S.
    Plasma next generation sequencing and droplet digital-qpcr-based quantification of circulating cell-free rna for noninvasive early detection of cancer
    In: Cancers Vol. 12 (2020) Nr. 2, pp. 353
    ISSN: 2072-6694
  • Krahn, Daniel; Heilmann, Geronimo; Vogel, Felix C. E.; Papadopoulos, Chrisovalantis; Zweerink, Susanne; Kaschani, Farnusch; Meyer, Hemmo; Rösch, Alexander; Kaiser, Markus
    Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product Family
    In: Chemistry: A European Journal Vol. 26 (2020) Nr. 39, pp. 8524 - 8531
    ISSN: 1521-3765; 0947-6539
  • Váraljai, Renáta; Wistuba-Hamprecht, Kilian; Seremet, Teofila; Diaz, Joey Mark S.; Nsengimana, Jérémie; Sucker, Antje; Griewank, Klaus; Placke, Jan-Malte; Horn, Peter A.; Neuhoff, Nils von; Shannan, Batool; Chauvistré, Heike; Vogel, Felix C.E.; Horn, Susanne; Becker, Jürgen; Newton-Bishop, Julia; Stang, Andreas; Neyns, Bart; Weide, Benjamin; Schadendorf, Dirk; Rösch, Alexander
    Application of circulating cell-free tumor DNA profiles for therapeutic monitoring and outcome prediction in genetically heterogeneous metastatic melanoma
    In: JCO Precision Oncology Vol. 3 (2019)
    ISSN: 2473-4284
  • Zaremba, Anne; Murali, Rajmohan; Jansen, Philipp; Möller, Inga; Sucker, Antje; Paschen, Annette; Zimmer, Lisa; Livingstone, Elisabeth; Brinker, Titus J.; Hadaschik, Eva; Franklin, Cindy; Rösch, Alexander; Ugurel, Selma; Schadendorf, Dirk; Griewank, Klaus; Cosgarea, Ioana
    Clinical and genetic analysis of melanomas arising in acral sites
    In: European Journal of Cancer Vol. 119 (2019) pp. 66 - 76
    ISSN: 1879-0852; 0959-8049
  • Zaremba, Anne; Chorti, Eleftheria; Jockenhöfer, Finja; Bolz, Saskia; Sirin, Selma; Glas, Martin; Becker, Jürgen C.; Ugurel, Selma; Rösch, Alexander; Schadendorf, Dirk; Livingstone, Elisabeth; Hagenacker, Tim; Zimmer, Lisa
    Metastatic Merkel cell carcinoma and myasthenia gravis : contraindication for therapy with immune checkpoint inhibitors?
    In: Journal for ImmunoTherapy of Cancer Vol. 7 (2019) Nr. 1, pp. 141
    ISSN: 2051-1426
  • Shannan, B.; Matschke, Johann; Chauvistré, Heike; Vogel, F.; Klein, Diana; Meier, Friedegund; Westphal, Dana; Bruns, Johannes; Rauschenberg, Ricarda; Utikal, Jochen; Forschner, Andrea; Berking, Carola; Terheyden, Patrick; Dabrowski, Evelyn; Gutzmer, Ralf; Rafei-Shamsabadi, David Ali; Meiss, Frank; Heinzerling, Lucie M.; Zimmer, Lisa; Livingstone, Elisabeth; Váraljai, Renáta; Hoewner, A.; Horn, Susanne; Klode, Joachim; Stuschke, Martin; Scheffler, Björn; Marchetto, Aruna; Sannino, Giuseppina; Grünewald, Thomas Georg Philipp; Schadendorf, Dirk; Jendrossek, Verena; Rösch, Alexander
    Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV⁶⁰⁰E inhibition in melanoma
    In: European Journal of Cancer Vol. 109 (2019) pp. 137 - 153
    ISSN: 1879-0852; 0959-8049
  • Vogel, Felix C. E.; Bordag, Natalie; Zügner, E.; Trajkovic-Arsic, Marija; Chauvistré, Heike; Shannan, Batool; Váraljai, Renáta; Horn, Susanne; Magnes, Christoph; Siveke, Jens; Schadendorf, Dirk; Rösch, Alexander
    Targeting the H3K4 Demethylase KDM5B Reprograms the Metabolome and Phenotype of Melanoma Cells
    In: The Journal of Investigative Dermatology Vol. 139 (2019) Nr. 12, pp. 2506 - 2516.e10
    ISSN: 1523-1747; 0022-202X
  • Varaljai, R.; Wistuba-Hamprecht, K.; Seremet, T.; Diaz, JMS; Nsengimana, J.; Sucker, A.; Griewank, Klaus; Horn, Peter; von Neuhoff, N.; Shannan, B.; Chauvistre, H.; Vogel, FCE; Horn, S.; Becker, J. C.; Newton-Bishop, J.; Stang, Andreas; Neyns, B.; Weide, B.; Schadendorf, Dirk; Rösch, Alexander
    ctDNA as a noninvasive monitoring tool in metastatic melanoma
    In: Journal of Clinical Oncology Vol. 37 (2019) Nr. Suppl. 15, pp. 9548
    ISSN: 0732-183X; 1527-7755
  • Wirtz, M.; Stoffels, Ingo; Dissemond, Joachim; Schadendorf, Dirk; Rösch, Alexander
    Actinic keratoses treated with cold atmospheric plasma
    In: Journal of the European Academy of Dermatology and Venereology Vol. 32 (2018) Nr. 1, pp. e37 - e39
    ISSN: 0926-9959; 1468-3083
  • Schadendorf, Dirk; Van Akkooi, Alexander; Berking, Carola; Griewank, Klaus; Gutzmer, Ralf; Hauschild, Axel; Stang, Andreas; Rösch, Alexander; Ugurel, Selma
    In: The Lancet Vol. 392 (2018) Nr. 10151, pp. 971 - 984
    ISSN: 0140-6736; 1474-547X
  • Kunz, Manfred; Löffler-Wirth, Henry; Dannemann, Michael; Willscher, Edith; Doose, Gero; Kelso, Janet; Kottek, Tina; Nickel, Birgit; Hopp, Lydia; Landsberg, Jenny; Hoffmann, Steve; Tüting, Thomas; Zigrino, Paola; Mauch, Cornelia; Utikal, Jochen; Ziemer, Mirjana; Schulze, Hans-Joachim; Hölzel, Michael; Rösch, Alexander; Kneitz, Susanne; Meierjohann, Svenja; Bosserhoff, Anja; Binder, Hans; Schartl, Manfred
    RNA-seq analysis identifies different transcriptomic types and developmental trajectories of primary melanomas
    In: Oncogene Vol. 37 (2018) Nr. 47, pp. 6136 - 6151
    ISSN: 0950-9232; 1476-5594
  • Jockenhöfer, Finja; Schimming, Tobias T.; Schaller, Jörg; Moege, Jürgen; Livingstone, Elisabeth; Salva, Katrin A.; Zimmer, Lisa; Schadendorf, Dirk; Rösch, Alexander
    Sebaceous tumours: more than skin deep
    In: Gut Vol. 67 (2018) Nr. 11, pp. 2045 - 2053
    ISSN: 0017-5749; 1468-3288
  • Krepler, Clemens; Sproesser, Katrin; Brafford, Patricia; Beqiri, Marilda; Garman, Bradley; Xiao, Min; Shannan, Batool; Watters, Andrea; Perego, Michela; Zhang, Gao; Vultur, Adina; Yin, Xiangfan; Liu, Qin; Anastopoulos, Ioannis N.; Wubbenhorst, Bradley; Wilson, Melissa A.; Xu, Wei; Karakousis, Giorgos; Feldman, Michael; Xu, Xiaowei; Amaravadi, Ravi; Gangadhar, Tara C.; Elder, David E.; Haydu, Lauren E.; Wargo, Jennifer A.; Davies, Michael A.; Lu, Yiling; Mills, Gordon B.; Frederick, Dennie T.; Barzily-Rokni, Michal; Flaherty, Keith T.; Hoon, Dave S.; Guarino, Michael; Bennett, Joseph J.; Ryan, Randall W.; Petrelli, Nicholas J.; Shields, Carol L.; Terai, Mizue; Sato, Takami; Aplin, Andrew E.; Rösch, Alexander; Darr, David; Angus, Steve; Kumar, Rakesh; Halilovic, Ensar; Caponigro, Giordano; Jeay, Sebastien; Wuerthner, Jens; Walter, Annette; Ocker, Matthias; Boxer, Matthew B.; Schuchter, Lynn; Nathanson, Katherine L.; Herlyn, Meenhard
    A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma
    In: Cell Reports Vol. 21 (2017) Nr. 7, pp. 1953 - 1967
    ISSN: 2211-1247
  • Ugurel, Selma; Kiecker, Felix; Fröhling, Stefan; Wetter, Axel; Bankfalvi, Agnes; Sucker, Antje; Zimmer, Lisa; Livingstone, Elisabeth; Rösch, Alexander; Becker, Jürgen; Schadendorf, Dirk
    Fulminant response to combined checkpoint inhibition with ipilimumab plus nivolumab after failure of nivolumab monotherapy in metastatic melanoma
    In: European Journal of Cancer Vol. 83 (2017) pp. 142 - 145
    ISSN: 0959-8049; 1879-2995
  • Franklin, Cindy; Livingstone, Elisabeth; Rösch, Alexander; Schilling, Bastian; Schadendorf, Dirk
    Immunotherapy in melanoma : Recent advances and future directions
    In: European Journal of Surgical Oncology Vol. 43 (2017) Nr. 3, pp. 604 - 611
    ISSN: 1532-2157; 0748-7983
  • Behera, Reeti; Kaur, Amanpreet; Webster, Marie R.; Kim, Suyeon; Ndoye, Abibatou; Kugel, Curtis H.; Alicea, Gretchen M.; Wang, Joshua; Ghosh, Kanad; Cheng, Phil; Lisanti, Sofia; Marchbank, Katie; Dang, Vanessa; Levesque, Mitchell; Dummer, Reinhard; Xu, Xiaowei; Herlyn, Meenhard; Aplin, Andrew E.; Rösch, Alexander; Caino, Cecilia; Altieri, Dario C.; Weeraratna, Ashani T.
    Inhibition of age-related therapy resistance in melanoma by rosiglitazone-mediated induction of klotho
    In: Clinical Cancer Research Vol. 23 (2017) Nr. 12, pp. 3181 - 3190
    ISSN: 1557-3265; 1078-0432
  • Brinker, Titus Josef; Schadendorf, Dirk; Klode, Joachim; Cosgarea, Ioana; Rösch, Alexander; Jansen, Philipp; Stoffels, Ingo; Izar, Benjamin
    Photoaging Mobile Apps as a Novel Opportunity for Melanoma Prevention: Pilot Study.
    In: JMIR mhealth and uhealth Vol. 5 (2017) Nr. 7,
    ISSN: 2291-5222
  • Heppt, Markus V.; Rösch, Alexander; Weide, Benjamin; Gutzmer, Ralf; Meier, Friedegund; Loquai, Carmen; Kähler, Katharina C.; Gesierich, Anja; Meissner, Markus; Bubnoff, Dagmar von; Göppner, Daniela; Schlaak, Max; Pföhler, Claudia; Utikal, Jochen; Heinzerling, Lucie; Cosgarea, Ioana; Engel, Jutta; Eckel, Renate; Martens, Alexander; Mirlach, Laura; Satzger, Imke; Schubert-Fritschle, Gabriele; Tietze, Julia K.; Berking, Carola
    Prognostic factors and treatment outcomes in 444 patients with mucosal melanoma
    In: European Journal of Cancer Vol. 81 (2017) pp. 36 - 44
    ISSN: 1879-2995; 0959-8049; 0014-2964; 1879-0852
  • Cosgarea, Ioana; Ugurel, Selma; Sucker, Antje; Livingstone, Elisabeth; Zimmer, Lisa; Ziemer, Mirjana; Utikal, Jochen; Mohr, Peter; Pfeiffer, Christiane; Pföhler, Claudia; Hillen, Uwe; Horn, Susanne; Schadendorf, Dirk; Griewank, Klaus; Rösch, Alexander
    Targeted next generation sequencing of mucosal melanomas identifies frequent NF1 and RAS mutations
    In: OncoTarget Vol. 8 (2017) Nr. 25, pp. 40683 - 40692
    ISSN: 1949-2553
  • Jockenhöfer, Finja; Gollnick, Harald; Herberger, Katharina; Isbary, Georg; Renner, Regina; Stücker, Markus; Valesky, Eva; Wollina, Uwe; Weichenthal, Michael; Karrer, Sigrid; Kuepper, Bernhard; Rösch, Alexander; Dissemond, Joachim
    Aetiology, comorbidities and cofactors of chronic leg ulcers : retrospective evaluation of 1 000 patients from 10 specialised dermatological wound care centers in Germany
    In: International Wound Journal Vol. 13 (2016) Nr. 5, pp. 821 - 828
    ISSN: 1742-4801; 1742-481X
  • Graf, Saskia Anna; Rösch, Alexander
    Arbeitsgemeinschaft Dermatologische Onkologie (ADO) : Bericht über den 3. ADO Nachwuchs-Retreat
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Vol. 14 (2016) Nr. 2, pp. 213 - 214
    ISSN: 1610-0387; 1563-2571; 1610-0379; 0301-0481
  • Herz, Saskia; Höfer, Thomas; Papapanagiotou, Matina; Leyh, Julia Christina; Meyenburg, Sarah; Schadendorf, Dirk; Ugurel, Selma; Rösch, Alexander; Livingstone, Elisabeth; Schilling, Bastian; Franklin, Cindy
    Checkpoint inhibitors in chronic kidney failure and an organ transplant recipient
    In: European Journal of Cancer Vol. 67 (2016) pp. 66 - 72
    ISSN: 0959-8049
  • Sondermann, Wiebke; Zimmer, Lisa; Schadendorf, Dirk; Rösch, Alexander; Klode, Joachim; Dissemond, Joachim
    Initial misdiagnosis of melanoma located on the foot is associated with poorer prognosis
    In: Medicine Vol. 95 (2016) Nr. 29, pp. e4332
    ISSN: 0025-7974
  • Facompre, Nicole D; Harmeyer, Kayla M; Sole, Xavier; Kabraji, Sheheryar; Belden, Zachary; Sahu, Varun; Whelan, Kelly; Tanaka, Koji; Weinstein, Gregory S; Montone, Kathleen T; Rösch, Alexander; Gimotty, Phyllis A; Herlyn, Meenhard; Rustgi, Anil K; Nakagawa, Hiroshi; Ramaswamy, Sridhar; Basu, Devraj
    JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers
    In: Cancer Research Vol. 76 (2016) Nr. 18, pp. 5538 - 5549
    ISSN: 0008-5472; 1538-7445
  • Livingstone, Elisabeth; Rösch, Alexander; Schadendorf, Dirk; Zimmer, Lisa; Schilling, Bastian
    Medikamentöse Therapie des metastasierten malignen Melanoms
    In: Arzneimitteltherapie Vol. 34 (2016) Nr. 1-2, pp. 14 - 22
    ISSN: 0723-6913
  • Zhao, Fang; Sucker, Antje; Horn, Susanne; Heeke, Christina; Bielefeld, Nicola; Schrörs, Barbara; Bicker, Anne; Lindemann, Monika; Rösch, Alexander; Gaudernack, Gustav; Stiller, Mathias; Becker, Jürgen; Lennerz, Volker; Wölfel, Thomas; Schadendorf, Dirk; Griewank, Klaus; Paschen, Annette
    Melanoma Lesions Independently Acquire T-cell Resistance during Metastatic Latency
    In: Cancer Research Vol. 76 (2016) Nr. 15, pp. 4347 - 4358
    ISSN: 0008-5472; 1538-7445
  • Jockenhöfer, Finja; Klode, Joachim; Kröger, Knut; Rösch, Alexander; Al Ghazal, Philipp; Dissemond, Joachim
    Patients with pyoderma gangrenosum - analyses of the German DRG data from 2012
    In: International Wound Journal Vol. 13 (2016) Nr. 5, pp. 951 - 956
    ISSN: 1742-4801; 1742-481X
  • Rösch, Alexander; Paschen, Annette; Landsberg, Jenny; Helfrich, Iris; Becker, Jürgen; Schadendorf, Dirk
    Phenotypic tumour cell plasticity as a resistance mechanism and therapeutic target in melanoma
    In: European Journal of Cancer Vol. 59 (2016) pp. 109 - 112
    ISSN: 0959-8049
  • Rompoti, Natalia; Hillen, Uwe; Rösch, Alexander; Dissemond, Joachim
    Purpura fulminans related to paroxysmal nocturnal haemoglobinuria
    In: European Journal of Dermatology, EJD Vol. 26 (2016) Nr. 4, pp. 397 - 398
    ISSN: 1167-1122
  • Stanisz, Hedwig; Bogeski, Ivan; Rösch, Alexander; Herlyn, Meenhard; Vultur, Adina
    The role of Orai–STIM calcium channels in melanocytes and melanoma
    In: The Journal of Physiology Vol. 594 (2016) Nr. 11, pp. 2825 - 2835
    ISSN: 1469-7793
  • Livingstone, Elisabeth; Swann, Suzanne; Lilla, Carmen; Schadendorf, Dirk; Rösch, Alexander
    Combining BRAF(V) (600E) inhibition with modulators of the mitochondrial bioenergy metabolism to overcome drug resistance in metastatic melanoma
    In: Experimental Dermatology Vol. 24 (2015) Nr. 9, pp. 709 - 710
    ISSN: 1600-0625; 0906-6705
  • Stoffels, Ingo; Morscher, S.; Helfrich, Iris; Hillen, Uwe; Lehy, J.; Burton, N. C.; Poppel, T.; Rösch, Alexander; Griewank, Klaus; Schadendorf, Dirk; Gunzer, Matthias; Klode, Joachim
    Die multispektraloptoakustische Tomographie (MSOT) zur nichtinvasiven Diagnostik des Schildwächterlymphknotens bei Patienten mit malignem Melanom
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Vol. 13 (2015) Nr. 12, pp. 1323
    ISSN: 1610-0387; 1563-2571; 1610-0379; 0301-0481
  • Schadendorf, Dirk; Fisher, David E; Garbe, Claus; Gershenwald, Jeffrey E; Grob, Jean-Jacques; Halpern, Allan; Herlyn, Meenhard; Marchetti, Michael A; McArthur, Grant; Ribas, Antoni; Rösch, Alexander; Hauschild, Axel
    In: Nature Reviews Disease Primers Vol. 1 (2015) pp. 15003
    ISSN: 2056-676X
  • Stoffels, Ingo; Morscher, Stefan; Helfrich, Iris; Hillen, Uwe; Leyh, Julia; Burton, Neal C.; Sardella, Thomas C.P.; Claussen, Jing; Pöppel, Thorsten; Bachmann, Hagen Sjard; Rösch, Alexander; Griewank, Klaus; Schadendorf, Dirk; Gunzer, Matthias; Klode, Joachim
    Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging
    In: Immunotherapy Vol. 7 (2015) Nr. 317, pp. 317ra199
    ISSN: 1750-743X; 1750-7448
  • Cierlitza, Monika; Chauvistré, Heike; Bogeski, Ivan; Zhang, Xin; Hauschild, Axel; Herlyn, Meenhard; Schadendorf, Dirk; Vogt, Thomas; Rösch, Alexander
    Mitochondrial oxidative stress as a novel therapeutic target to overcome intrinsic drug resistance in melanoma cell subpopulations
    In: Experimental Dermatology Vol. 24 (2015) Nr. 2, pp. 155 - 157
    ISSN: 1600-0625; 0906-6705
  • Schadendorf, Dirk; Livingstone, Elisabeth; Schilling, Bastian; Rösch, Alexander; Zimmer, Lisa
    Therapie des malignen Melanoms
    In: Der Onkologe Vol. 21 (2015) Nr. 10, pp. 965 - 974
    ISSN: 0947-8965
  • Rösch, Alexander
    Tumor heterogeneity and plasticity as elusive drivers for resistance to MAPK pathway inhibition in melanoma
    In: Oncogene Vol. 34 (2015) Nr. 23, pp. 2951 - 2957
    ISSN: 0950-9232; 1476-5594
  • Rösch, Alexander
    Tumorstammzellen im Melanom
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Vol. 13 (2015) Nr. 2, pp. 118 - 124
    ISSN: 1610-0387; 1563-2571; 1610-0379; 0301-0481
  • Rösch, Alexander
    'TWIST and switch' metastasis
    In: Pigment Cell and Melanoma Research Vol. 27 (2014) Nr. 2, pp. 157 - 158
    ISSN: 1755-1471; 1755-148X
  • Rösch, Alexander; Weber, Christiane
    Arbeitsgemeinschaft Dermatologische Onkologie (ADO)
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Vol. 12 (2014) Nr. 1, pp. 96 - 97
    ISSN: 1610-0387; 1563-2571; 1610-0379; 0301-0481
  • Jockenhöfer, Finja; Chapot, le Saout, Valerie; Stoffels-Weindorf, Maren; Körber, Andreas; Klode, Joachim; Buer, Jan; Küpper, Bernhard; Rösch, Alexander; Dissemond, Joachim
    Bacterial spectrum colonizing chronic leg ulcers : a 10-year comparison from a German wound care center
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Vol. 12 (2014) Nr. 12, pp. 1121 - 1127
    ISSN: 1610-0387; 1563-2571; 1610-0379; 0301-0481
  • Stanisz, Hedwig; Saul, Stephanie; Müller, Cornelia S.L.; Kappl, Reinhard; Niemeyer, Barbara A.; Vogt, Thomas; Hoth, Markus; Rösch, Alexander; Bogeski, Ivan
    Inverse regulation of melanoma growth and migration by Orai1/STIM2-dependent calcium entry
    In: Pigment Cell and Melanoma Research Vol. 27 (2014) Nr. 3, pp. 442 - 453
    ISSN: 1755-1471; 1755-148X
  • Wang, Tao; Ge, Yingbin; Xiao, Min; Lopez-Coral, Alfonso; Li, Ling; Rösch, Alexander; Huang, Catherine; Alexander, Peter; Vogt, Thomas; Xu, Xiaowei; Hwang, Wei-Ting; Lieu, Melissa; Belser, Eric; Liu, Rui; Somasundaram, Rajasekharan; Herlyn, Meenhard; Kaufman, Russel E
    SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway
    In: The Journal of Investigative Dermatology Vol. 134 (2014) Nr. 4, pp. 1108 - 1118
    ISSN: 0022-202X; 1523-1747
  • Niessner, Heike; Forschner, Andrea; Klumpp, Bernhard; Honegger, Jürgen B; Witte, Maria; Bornemann, Antje; Dummer, Reinhard; Adam, Annemarie; Bauer, Jürgen; Tabatabai, Ghazaleh; Flaherty, Keith; Sinnberg, Tobias; Beck, Daniela; Leiter, Ulrike; Mauch, Cornelia; Rösch, Alexander; Weide, Benjamin; Eigentler, Thomas; Schadendorf, Dirk; Garbe, Claus; Kulms, Dagmar; Quintanilla-Martinez, Leticia; Meier, Friedegund
    Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases.
    In: Cancer Medicine Vol. 2 (2013) Nr. 1, pp. 76 - 85
    ISSN: 2045-7634