ZMB Member Barbara Saccà

ZMB Member
Barbara Saccà

Next ZMB-Member
portrait photo of ZMB member Barbara Saccà
© UDE/B.Saccà

Prof. Dr. Barbara Saccà

Center of Medical Biotechnology (ZMB)
Faculty of Biology
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen

Research Overview

We use DNA nanotechnology to construct simplified models of complex biological systems, where single structural and functional parameters can be manipulated in a predictable fashion. Our scientific ambition is to gain a better understanding of three fundamental aspects of natural self-assembling systems: hierarchical order, spatial confinement, and dynamic response.

Figure: DNA Nanotechnology - from molecules to self-organized nanostructures
© B.Saccà
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Selected Publications

    Journal articles

  • Winat, Lena; Sacca, Barbara
    The primordial life of DNA dynamic networks
    In: Nature Catalysis Vol. 3 (2020) Nr. 11, pp. 865 - 866
    ISSN: 2520-1158
  • Kosinski, Richard; Mukhortava, Ann; Pfeifer, Wolfgang; Candelli, Andrea; Rauch, Philipp; Sacca, Barbara
    Sites of high local frustration in DNA origami
    In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1061
    ISSN: 2041-1723
  • Pfeifer, Wolfgang; Lill, Pascal; Gatsogiannis, Christos; Sacca, Barbara
    Hierarchical Assembly of DNA Filaments with Designer Elastic Properties
    In: ACS Nano Vol. 12 (2018) Nr. 1, pp. 44 - 55
    ISSN: 1936-086X; 1936-0851
  • Sprengel, Andreas; Lill, Pascal; Stegemann, Pierre; Bravo-Rodriguez, Kenny; Schöneweiß, Elisa-Charlott; Merdanovic, Melisa; Gudnason, Daniel; Aznauryan, Mikayel; Gamrad; Barcikowski, Stephan; Sanchez-Garcia, Elsa; Birkedal, Victoria; Gatsogiannis, Christos; Ehrmann, Michael; Sacca, Barbara
    Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactions
    In: Nature Communications Vol. 8 (2017) pp. 14472
    ISSN: 2041-1723
  • Streich, Carmen; Akkari, Laura; Decker, Christina; Bormann, Jenny; Rehbock, Christoph; Müller-Schiffmann, Andreas; Niemeyer, Felix; Nagel-Steger, Luitgard; Willbold, Dieter; Sacca, Barbara; Kor, Carsten
    Characterizing the Effect of Multivalent Conjugates Composed of Aβ-Specific Ligands and Metal Nanoparticles on Neurotoxic Fibrillar Aggregation
    In: ACS Nano (2016) pp. 7582 - 7597
    ISSN: 1936-086X; 1936-0851
  • Poepsel, Simon; Sprengel, Andreas; Sacca, Barbara; Kaschani, Farnusch; Kaiser, Markus; Gatsogiannis, Christos; Raunser, Stefan; Clausen, Tim; Ehrmann, Michael
    Determinants of amyloid fibril degradation by the PDZ protease HTRA1
    In: Nature Chemical Biology Vol. 11 (2015) Nr. 11, pp. 862 - 869
    ISSN: 1552-4450; 1552-4469
  • Sacca, Barbara; Ishitsuka, Yuji; Meyer, Rebecca; Sprengel, Andreas; Schöneweiß, Elisa-Charlott; Nienhaus, G. Ulrich; Niemeyer, Christof M.
    Reversible reconfiguration of DNA origami nanochambers monitored by single-molecule FRET
    In: Angewandte Chemie International Edition Vol. 54 (2015) Nr. 12, pp. 3592 - 3597
    ISSN: 1433-7851; 1521-3773
  • Meyer, Rebecca; Sacca, Barbara; Niemeyer, Christof M.
    Site-Directed, on-surface assembly of DNA nanostructures
    In: Angewandte Chemie International Edition Vol. 54 (2015) Nr. 41, pp. 12039 - 12043
    ISSN: 1433-7851
  • Sacca, Barbara; Niemeyer, Christof M.
    DNA Origami : The Art of Folding DNA
    In: Angewandte Chemie International Edition Vol. 51 (2012) Nr. 1, pp. 58 - 66
    ISSN: 1521-3773; 0570-0833
  • Sacca, Barbara; Niemeyer, Christof M.
    Functionalization of DNA nanostructures with proteins
    In: Chemical Society Reviews Vol. 40 (2011) Nr. 12, pp. 5910 - 5921
    ISSN: 1460-4744; 0306-0012
  • Sacca, Barbara; Niemeyer, Christof M.; Rabe, Kersten; Schroeder, Hendrik; Arndt, Andreas; Kiko, Kathrin; Erkelenz, Michael; Meyer, Rebecca
    Orthogonal Protein Decoration of DNA Origami
    In: Angewandte Chemie International Edition Vol. 49 (2010) Nr. 49, pp. 9378 - 9383
    ISSN: 1521-3773
  • Feldkamp, Udo; Niemeyer, Christof M.; Sacca, Barbara
    Dendritic DNA Building Blocks for Amplified Detection Assays and Biomaterials
    In: Angewandte Chemie International Edition Vol. 48 (2009) Nr. 33, pp. 5996 - 6000
    ISSN: 1521-3773; 0570-0833
  • Sacca, Barbara; Niemeyer, Christof M.; Meyer, Rebecca
    Temperature-dependent FRET spectroscopy for the high-throughput analysis of self-assembled DNA nanostructures in real time
    In: Nature protocols Vol. 4 (2009) Nr. 3, pp. 271 - 285
    ISSN: 1750-2799
  • Sacca, Barbara; Niemeyer, Christof M.; Schroeder, Hendrik; Feldkamp, Udo; Meyer, Rebecca
    High-Throughput, Real-Time Monitoring of the Self-Assembly of DNA Nanostructures by FRET Spectroscopy
    In: Angewandte Chemie International Edition Vol. 47 (2008) Nr. 11, pp. 2135 - 2137
    ISSN: 1521-3773; 0570-0833
  • Mergny, Jean-Louis; De Cian, Anne; Ghelab, Amar; Sacca, Barbara; Lacroix, Laurent
    Kinetics of tetramolecular quadruplexes
    In: Nucleic Acids Research Vol. 33 (2005) Nr. 1, pp. 81 - 94
    ISSN: 1362-4962
  • Amrane, Samir; Sacca, Barbara; Mills, Martin; Chauhan, Madhu; Klump, Horst H.; Mergny, Jean-Louis
    Length-dependent energetics of (CTG)n and (CAG)n trinucleotide repeats
    In: Nucleic Acids Research Vol. 33 (2005) Nr. 13, pp. 4065 - 4077
    ISSN: 1362-4962; 1362-4962
  • Sacca, Barbara; Lacroix, Laurent; Mergny, Jean-Louis
    The effect of chemical modifications on the thermal stability of different G-quadruplex-forming oligonucleotides
    In: Nucleic Acids Research Vol. 33 (2005) Nr. 4, pp. 1182 - 1192
    ISSN: 1362-4962; 1362-4962