ZMB Member Barbara Saccà
ZMB Member
Barbara Saccà
Next ZMB-Member
Prof. Dr. Barbara Saccà
Group
BionanotechnologyCenter of Medical Biotechnology (ZMB)
Faculty of Biology
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen
- +49 201 183 3395
- Website
- Press Releases
- Selected Publications
- Publication Metrics
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- ZMB Research Program
Molecular and Chemical Cell Biology
Research Overview
We use DNA nanotechnology to construct simplified models of complex biological systems, where single structural and functional parameters can be manipulated in a predictable fashion. Our scientific ambition is to gain a better understanding of three fundamental aspects of natural self-assembling systems: hierarchical order, spatial confinement, and dynamic response.

Selected Publications
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A modular DNA origami nanocompartment for engineering a cell-free, protein unfolding and degradation pathwayIn: Nature Nanotechnology , Vol. 19 2024, Nr. 10, pp. 1521 – 1531DOI (Open Access)
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The primordial life of DNA dynamic networksIn: Nature Catalysis , Vol. 3 2020, Nr. 11, pp. 865 – 866
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Sites of high local frustration in DNA origamiIn: Nature Communications , Vol. 10 2019, Nr. 1, pp. 1061DOI (Open Access)
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Hierarchical Assembly of DNA Filaments with Designer Elastic PropertiesIn: ACS Nano , Vol. 12 2018, Nr. 1, pp. 44 – 55
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Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactionsIn: Nature Communications , Vol. 8 2017, pp. 14472DOI, Online Full Text (Open Access)
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Characterizing the Effect of Multivalent Conjugates Composed of Aβ-Specific Ligands and Metal Nanoparticles on Neurotoxic Fibrillar AggregationIn: ACS Nano 2016, pp. 7582 – 7597
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Determinants of amyloid fibril degradation by the PDZ protease HTRA1In: Nature Chemical Biology , Vol. 11 2015, Nr. 11, pp. 862 – 869DOI (Open Access)
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Reversible reconfiguration of DNA origami nanochambers monitored by single-molecule FRETIn: Angewandte Chemie International Edition , Vol. 54 2015, Nr. 12, pp. 3592 – 3597
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Site-Directed, on-surface assembly of DNA nanostructuresIn: Angewandte Chemie International Edition , Vol. 54 2015, Nr. 41, pp. 12039 – 12043
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DNA Origami : The Art of Folding DNAIn: Angewandte Chemie International Edition , Vol. 51 2012, Nr. 1, pp. 58 – 66
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Functionalization of DNA nanostructures with proteinsIn: Chemical Society Reviews , Vol. 40 2011, Nr. 12, pp. 5910 – 5921
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Orthogonal Protein Decoration of DNA OrigamiIn: Angewandte Chemie International Edition , Vol. 49 2010, Nr. 49, pp. 9378 – 9383
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Dendritic DNA Building Blocks for Amplified Detection Assays and BiomaterialsIn: Angewandte Chemie International Edition , Vol. 48 2009, Nr. 33, pp. 5996 – 6000
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High-Throughput, Real-Time Monitoring of the Self-Assembly of DNA Nanostructures by FRET SpectroscopyIn: Angewandte Chemie International Edition , Vol. 47 2008, Nr. 11, pp. 2135 – 2137
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Kinetics of tetramolecular quadruplexesIn: Nucleic Acids Research , Vol. 33 2005, Nr. 1, pp. 81 – 94
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Length-dependent energetics of (CTG)n and (CAG)n trinucleotide repeatsIn: Nucleic Acids Research , Vol. 33 2005, Nr. 13, pp. 4065 – 4077
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The effect of chemical modifications on the thermal stability of different G-quadruplex-forming oligonucleotidesIn: Nucleic Acids Research , Vol. 33 2005, Nr. 4, pp. 1182 – 1192