ZMB Member Dirk Schadendorf

ZMB Member
Dirk Schadendorf

Next ZMB-Member
Dirk Schadendorf portrait
© UKE

Prof. Dr. Dirk Schadendorf

Director of:

Clinic for Dermatology

University Hospital Essen
Hufelandstraße 55
45147 Essen

Research Overview

  • Malignant melanoma
  • Merkel cell carcinoma
  • Squamous cell carcinoma
  • Basal cell carcinoma
  • Mycosis Fungoides/Sezary syndrome (T-Zell-Non-Hodgkin-Lymphoma)
  • Application observation

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Selected Publications

    Journal articles

  • Cortés-Ciriano, Isidro; Küppers, Ralf; Schadendorf, Dirk; Park, Peter J.
    Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
    In: Nature Genetics Vol. 55 (2023) Nr. 6, 1076
    Online Full Text: dx.doi.org/ (Open Access)
  • Yuan, Yuan; Küppers, Ralf; Schadendorf, Dirk; Park, Keunchil; Campbell, Peter J.; Liang, Han
    Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers
    In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1078
    Online Full Text: dx.doi.org/ (Open Access)
  • Akdemir, Kadir C.; Küppers, Ralf; Schadendorf, Dirk; Futreal, P. Andrew
    Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
    In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1079
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, et.al.
    Author Correction: Pan-cancer analysis of whole genomes
    In: Nature Vol. 614 (2023) Nr. 7948, pp. E39
    Online Full Text: dx.doi.org/ (Open Access)
  • Rodriguez-Martin, Bernardo; Schadendorf, Dirk; Campbell, Peter J.
    Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
    In: Nature Genetics Vol. 55 (2023) Nr. 6, 1080
    Online Full Text: dx.doi.org/ (Open Access)
  • Zapatka, Marc; Schadendorf, Dirk; Lichter, Peter
    Author Correction: The landscape of viral associations in human cancers
    In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1077
    Online Full Text: dx.doi.org/ (Open Access)
  • Cortés-Ciriano, Isidro; Küppers, Ralf; Schadendorf, Dirk; Park, Peter J.
    Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
    In: Nature Genetics Vol. 52 (2023) pp. 331 - 341
    Online Full Text: dx.doi.org/ (Open Access)
  • Yuan, Yuan; Küppers, Ralf; Schadendorf, Dirk; Park, Keunchil; Campbell, Peter J.; Liang, Han
    Comprehensive molecular characterization of mitochondrial genomes in human cancers
    In: Nature Genetics Vol. 52 (2023) pp. 342 - 352
    Online Full Text: dx.doi.org/ (Open Access)
  • Akdemir, Kadir C.; Küppers, Ralf; Schadendorf, Dirk; Futreal, P. Andrew
    Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
    In: Nature Genetics Vol. 52 (2023) Nr. 3, pp. 294 - 305
    Online Full Text: dx.doi.org/ (Open Access)
  • Garbe, Claus; Dummer, Reinhard; Amaral, Teresa; Amaria, Rodabe N.; Ascierto, Paolo A.; Burton, Elizabeth M.; Dreno, Brigitte; Eggermont, Alexander M. M.; Hauschild, Axel; Hoeller, Christoph; Kaufmann, Roland; Lebbe, Celeste; Mandala, Mario; Menzies, Alexander M.; Moreno, David; Michielin, Olivier; Nathan, Paul; Patel, Sapna P.; Robert, Caroline; Schadendorf, Dirk; Lorigan, Paul C.; Scolyer, Richard A.; Tawbi, Hussein A.; van de Wiel, Bart A.; Blank, Christian; Long, Georgina V.
    Neoadjuvant immunotherapy for melanoma is now ready for clinical practice
    In: Nature Medicine Vol. 29 (2023) Nr. 6, pp. 1310 - 1312
    Online Full Text: dx.doi.org/
  • Rodriguez-Martin, Bernardo; Schadendorf, Dirk; Campbell, Peter J.
    Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
    In: Nature Genetics Vol. 52 (2023) Nr. 3, pp. 306 - 319
    Online Full Text: dx.doi.org/ (Open Access)
  • Illert, A.L.; Stenzinger, A.; Bitzer, M.; Horak, P.; Gaidzik, V.I.; Möller, Y.; Beha, J.; Öner, Ö.; Schmitt, F.; Laßmann, S.; Ossowski, S.; Schaaf, C.P.; Hallek, M.; Brümmendorf, T.H.; Albers, P.; Fehm, T.; Brossart, P.; Glimm, H.; Schadendorf, Dirk; Bleckmann, A.; Brandts, C.H.; Esposito, I.; Mack, E.; Peters, C.; Bokemeyer, C.; Fröhling, S.; Kindler, T.; Algül, H.; Heinemann, V.; Döhner, H.; Bargou, R.; Ellenrieder, V.; Hillemanns, P.; Lordick, F.; Hochhaus, A.; Beckmann, M.W.; Pukrop, T.; Trepel, M.; Sundmacher, L.; Wesselmann, S.; Nettekoven, G.; Kohlhuber, F.; Heinze, O.; Budczies, J.; Werner, M.; Nikolaou, K.; Beer, A.J.; Tabatabai, G.; Weichert, W.; Keilholz, U.; Boerries, M.; Kohlbacher, O.; Duyster, J.; Thimme, R.; Seufferlein, T.; Schirmacher, P.; Malek, N.P.
    The German Network for Personalized Medicine to enhance patient care and translational research
    In: Nature Medicine Vol. 29 (2023) Nr. 6, pp. 1298 - 1301
    Online Full Text: dx.doi.org/
  • Zapatka, Marc; Schadendorf, Dirk; Lichter, Peter
    The landscape of viral associations in human cancers
    In: Nature Genetics (2023) Nr. 52, pp. 320 - 330
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Creighton, Chad J.; PCAWG Consortium
    Author Correction : High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
    In: Nature Communications Vol. 13 (2022) 7572
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Macintyre, Geoff; PCAWG Consortium
    Author Correction : Inferring structural variant cancer cell fraction
    In: Nature Communications Vol. 13 (2022) 7568
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Stein, Lincoln D.; PCAWG Consortium
    Author Correction : A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
    In: Nature Communications Vol. 13 (2022) 7573
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Bristow, Robert G.; Boutros, Paul C.; PCAWG Consortium
    Author Correction : Divergent mutational processes distinguish hypoxic and normoxic tumours
    In: Nature Communications Vol. 13 (2022) 7569
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Morris, Quaid D.; PCAWG Consortium
    Author Correction : Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
    In: Nature Communications Vol. 13 (2022) 7567
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Feuerbach, Lars; PCAWG Consortium
    Author Correction : Genomic footprints of activated telomere maintenance mechanisms in cancer
    In: Nature Communications Vol. 13 (2022) 7574
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Reimand, Jüri; PCAWG Consortium
    Author Correction : Pathway and network analysis of more than 2500 whole cancer genomes
    In: Nature Communications Vol. 13 (2022) 7566
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Reimand, Jüri; PCAWG Drivers and Functional Interpretation Working Group; PCAWG Consortium
    Author Correction : Integrative pathway enrichment analysis of multivariate omics data
    In: Nature Communications Vol. 13 (2022) 7570
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Shuai, Shimin; Stein, Lincoln D.; PCAWG Drivers and Functional Interpretation Working Group; PCAWG Consortium
    Author Correction : Combined burden and functional impact tests for cancer driver discovery using DriverPower
    In: Nature Communications Vol. 13 (2022) 7571
    Online Full Text: dx.doi.org/ (Open Access)
  • Long, Georgina V; Luke, Jason J; Khattak, Muhammad A; de la Cruz Merino, Luis; Del Vecchio, Michele; Rutkowski, Piotr; Spagnolo, Francesco; Mackiewicz, Jacek; Chiarion-Sileni, Vanna; Kirkwood, John M; Robert, Caroline; Grob, Jean-Jacques; de Galitiis, Federica; Schadendorf, Dirk; Carlino, Matteo S; Mohr, Peter; Dummer, Reinhard; Gershenwald, Jeffrey E; Yoon, Charles H; Wu, Xi Lawrence; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Eggermont, Alexander M M; Ascierto, Paolo A
    Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716) : distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial
    In: The Lancet Oncology Vol. 23 (2022) Nr. 11, pp. 1378 - 1388
    Online Full Text: dx.doi.org/
  • Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Jürgen; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodríguez-López, José Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Rösch, Alexander
    Persister state-directed transitioning and vulnerability in melanoma
    In: Nature Communications Vol. 13 (2022) Nr. 1, 3055
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Bottomley, Andrew; Coens, Corneel; Mierzynska, Justyna; Blank, Christian U; Mandalà, Mario; Long, Georgina V; Atkinson, Victoria G; Dalle, Stéphane; Haydon, Andrew M; Meshcheryakov, Andrey; Khattak, Adnan; Carlino, Matteo S; Sandhu, Shahneen; Puig, Susana; Ascierto, Paolo A; Larkin, James; Lorigan, Paul C; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Di Giacomo, Anna Maria; van den Eertwegh, Alfonsus J M; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; van Akkooi, Alexander C J; Krepler, Clemens; Ibrahim, Nageatte; Marreaud, Sandrine; Kicinski, Michal; Suciu, Stefan; Robert, Caroline; Eggermont, Alexander M M; Lesimple, Thierry; Maio, Michele; Linette, Gerald; Mortier, Laurent; Svane, Inge Marie; Schachter, Jacob; Brown, Michael; Hersey, Peter; Barrow, Catherine; Kudchadkar, Ragini; Dutriaux, Caroline; Song, Xinni; Quaglino, Pietro; Queirolo, Paola; Meier, Friedegund; Stroyakovskiy, Daniil; Guillot, Bernard; Romero, Pablo Luis Ortiz; Bastholt, Lars; Garbe, Claus; Grange, Florent; Mohr, Peter; Algazi, Alain; Bechter, Oliver; Hernberg, Micaela; Loquai, Carmen; Meiss, Frank; Chiarion Sileni, Vanna; Bar-Sela, Gil; Fitzharris, Bernard; Saiag, Philippe; Arnault, Jean-Philippe; Simon, Jan-Christoph; Stephens, Rosalie; Baurain, Jean-Francois; Lebbe, Célèste; Combemale, Patrick; Dummer, Reinhard; Hauschild, Axel; Parente, Phillip; Yamazaki, Naoya; Milhem, Mohammed; Leccia, Marie-Thérèse; Geoffrois, Lionel; Kretschmer, Lutz; Dunwoodie, Elaine; Walker, John; Lotem, Michal; Hendler, Daniel; Mackiewicz, Andrzej; Sekulovic, Lidija; Dzienis, Marcin; Hospers, Geke A.P.; Siano, Marco; Hassel, Jessica; Corrie, Philippa; Passos, Maria-Jose; Levin, Max; Hoeller, Christoph; Machet, Laurent; Hallmeyer, Sigrun; Waterston, Ashita; Descamps, Vincent; Kiecker, Felix; Aarts, Maureen; Schmidt, Henrik; Raimundo, Ana; Nyakas, Marta; Lacour, Jean-Philippe; Berking, Carola; Ferrucci, Pier Francesco; Jameson, Michael; Kim, Kevin; Yokota, Kenji; Kerger, Joseph; Aubin, François; Groenewegen, Gerard; Kapiteijn, Helena; Boehncke, Wolf-Henning; Utikal, Jochen; Casasola, Richard; Marshall, Ernest; Ferraresi, Virginia; Richtig, Erika; Matkovic, Suzana; Inozume, Takashi; Crook, Timothy; McNeil, Catriona; Kiyohara, Yoshio; Avril, Marie-Francoise; Hein, Rüdiger; Terheyden, Patrick; Nathan, Paul; Aoi, Jun; Skytta, Tanja; Jouary, Thomas; Takenouchi, Tatsuya; Straume, Oddbjorn; Martins, César; Mukhametshina, Guzel
    Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial
    In: The Lancet Oncology Vol. 22 (2021) Nr. 5, pp. 655 - 664
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Eggermont, Alexander M M; Blank, Christian U; Mandalà, Mario; Long, Georgina V; Atkinson, Victoria G; Dalle, Stéphane; Haydon, Andrew M; Meshcheryakov, Andrey; Khattak, Adnan; Carlino, Matteo S; Sandhu, Shahneen; Larkin, James; Puig, Susana; Ascierto, Paolo A; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Di Giacomo, Anna Maria; van den Eertwegh, Alfonsus J M; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; Lorigan, Paul C; van Akkooi, Alexander C J; Krepler, Clemens; Ibrahim, Nageatte; Marreaud, Sandrine; Kicinski, Michal; Suciu, Stefan; Robert, Caroline; Menzies, Alex; Lesimple, Thierry; Maio, Michele; Linette, Gerald; Brown, Michael; Hersey, Peter; Svane, Inge Marie; Mortier, Laurent; Schachter, Jacob; Barrow, Catherine; Kudchadkar, Ragini; Song, Xinni; Dutriaux, Caroline; Quaglino, Pietro; Meier, Friedegund; Queirolo, Paola; Stroyakovskiy, Daniil; Bastholt, Lars; Guillot, Bernard; Garbe, Claus; Ortiz Romero, Pablo Luis; Grange, Florent; Mohr, Peter; Algazi, Alain; Bechter, Oliver; Hernberg, Micaela; Arnault, Jean-Philippe; Saiag, Philippe; Loquai, Carmen; Meiss, Frank; Simon, Jan-Christoph; Bar-Sela, Gil; Chiarion Sileni, Vanna; Fitzharris, Bernard; McCrystal, Mike; Parente, Phillip; Baurain, Jean-Francois; Combemale, Patrick; Lebbe, Célèste; Hauschild, Axel; Yamazaki, Naoya; Dummer, Reinhard; Milhem, Mohammed; Dzienis, Marcin; Walker, John; Geoffrois, Lionel; Leccia, Marie-Thérèse; Kretschmer, Lutz; Hendler, Daniel; Lotem, Michal; Mackiewicz, Andrzej; Sekulovic, Lidija; Dunwoodie, Elaine; Hoeller, Christoph; Machet, Laurent; Hassel, Jessica; Hospers, Geke A.P.; Passos, Maria-Jose; Levin, Max; Fehr, Martin; Corrie, Philippa; Waterston, Ashita; Hallmeyer, Sigrun; Schmidt, Henrik; Descamps, Vincent; Lacour, Jean-Philippe; Berking, Carola; Kiecker, Felix; Ferrucci, Pier Francesco; Yokota, Kenji; Aarts, Maureen; Jameson, Michael; Winge-Main, Anna Katharina; Ferreira, Paula; Kim, Kevin; McNeil, Catriona; Hofmann-Wellenhof, Reiner; Kerger, Joseph; Aubin, François; Utikal, Jochen; Ferraresi, Virginia; Inozume, Takashi; Kiyohara, Yoshio; Groenewegen, Gerard; Kapiteijn, Helena; Matkovic, Suzana; Boehncke, Wolf-Henning; Casasola, Richard; Crook, Timothy; Marshall, Ernest; Skytta, Tanja; Avril, Marie-Francoise; Jouary, Thomas; Hein, Rüdiger; Terheyden, Patrick; Aoi, Jun; Takenouchi, Tatsuya; Straume, Oddbjorn; Martins, César; Mukhametshina, Guzel; Nathan, Paul
    Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : distant metastasis-free survival results from a double-blind, randomised, controlled, phase 3 trial
    In: The Lancet Oncology Vol. 22 (2021) Nr. 5, pp. 643 - 654
    Online Full Text: dx.doi.org/
  • Syeda, Mahrukh M.; Wiggins, Jennifer M.; Corless, Broderick C; Long, Georgina V.; Flaherty, Keith T.; Schadendorf, Dirk; Nathan, Paul D.; Robert, Caroline; Ribas, Antoni; Davies, Michael A.; Grob, Jean Jacques; Gasal, Eduard; Squires, Matthew; Marker, Mahtab; Garrett, James; Brase, Jan C.; Polsky, David
    Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib : A clinical validation study
    In: The Lancet Oncology Vol. 22 (2021) Nr. 3, pp. 370 - 380
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Le Rhun, E.; Guckenberger, M.; Smits, M.; Dummer, R.; Bachelot, T.; Sahm, F.; Galldiks, N.; de Azambuja, E.; Berghoff, A.S.; Metellus, P.; Peters, S.; Hong, Y.-K.; Winkler, F.; Schadendorf, Dirk; van den Bent, M.; Seoane, J.; Stahel, R.; Minniti, G.; Wesseling, P.; Weller, M.; Preusser, M.
    EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours
    In: Annals of Oncology Vol. 32 (2021) Nr. 11, pp. 1332 - 1347
    Online Full Text: dx.doi.org/ (Open Access)
  • Frangieh, Chris J.; Melms, Johannes C.; Thakore, Pratiksha I.; Geiger-Schuller, Kathryn R.; Ho, Patricia; Luoma, Adrienne M.; Cleary, Brian; Jerby-Arnon, Livnat; Malu, Shruti; Cuoco, Michael S.; Zhao, Maryann; Ager, Casey R.; Rogava, Meri; Hovey, Lila; Rotem, Asaf; Bernatchez, Chantale; Wucherpfennig, Kai W.; Johnson, Bruce E.; Rozenblatt-Rosen, Orit; Schadendorf, Dirk; Regev, Aviv; Izar, Benjamin
    Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion
    In: Nature Genetics Vol. 53 (2021) Nr. 3, pp. 332 - 341
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Stein, Lincoln D.; PCAWG Consortium
    A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
    In: Nature Communications Vol. 11 (2020) 728
    Online Full Text: dx.doi.org/ (Open Access)
  • Dummer, Reinhard; Brase, Jan C.; Garrett, James; Campbell, Catarina D.; Gasal, Eduard; Squires, Matthew; Gusenleitner, Daniel; Santinami, Mario; Atkinson, Victoria; Mandalà, Mario; Chiarion-Sileni, Vanna; Flaherty, Keith; Larkin, James; Robert, Caroline; Kefford, Richard; Kirkwood, John M.; Hauschild, Axel; Schadendorf, Dirk; Long, Georgina V.
    Adjuvant dabrafenib plus trametinib versus placebo in patients with resected, BRAFV⁶⁰⁰-mutant, stage III melanoma (COMBI-AD) : Exploratory biomarker analyses from a randomised, phase 3 trial
    In: The Lancet Oncology Vol. 21 (2020) Nr. 3, pp. 358 - 372
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Eggermont, Alexander M. M.; Kicinski, Michal; Blank, Christian U.; Mandala, Mario; Long, Georgina V.; Atkinson, Victoria; Dalle, Stéphane; Haydon, Andrew; Khattak, Adnan; Carlino, Matteo S.; Sandhu, Shahneen; Larkin, James; Puig, Susana; Ascierto, Paolo A.; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Di Giacomo, Anna Maria; Van Den Eertwegh, Alfonsus J. M.; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; Lorigan, Paul C.; Krepler, Clemens; Ibrahim, Nageatte; Marreaud, Sandrine; Van Akkooi, Alexander; Robert, Caroline; Suciu, Stefan
    Association between Immune-Related Adverse Events and Recurrence-Free Survival among Patients with Stage III Melanoma Randomized to Receive Pembrolizumab or Placebo : A Secondary Analysis of a Randomized Clinical Trial
    In: JAMA Oncology Vol. 6 (2020) Nr. 4, pp. 519 - 527
    Online Full Text: dx.doi.org/ (Open Access)
  • Puzanov, Igor; Ribas, Antoni; Robert, Caroline; Schachter, Jacob; Nyakas, Marta; Daud, Adil; Arance, Ana; Carlino, Matteo S.; O'Day, Steven J.; Long, Georgina V.; Margolin, Kim A.; Dummer, Reinhard; Schadendorf, Dirk; Lutzky, Jose; Ascierto, Paolo A.; Tarhini, Ahmad; Lin, Jianxin; Mogg, Robin; Homet Moreno, Blanca; Ibrahim, Nageatte; Hamid, Omid
    Association of BRAF V600E/K Mutation Status and Prior BRAF/MEK Inhibition with Pembrolizumab Outcomes in Advanced Melanoma : Pooled Analysis of 3 Clinical Trials
    In: JAMA Oncology Vol. 6 (2020) Nr. 8, pp. 1256 - 1264
    Online Full Text: dx.doi.org/ (Open Access)
  • Liu, David; Schilling, Bastian; Liu, Derek; Sucker, Antje; Livingstone, Elisabeth; Jerby-Arnon, Livnat; Zimmer, Lisa; Gutzmer, Ralf; Satzger, Imke; Loquai, Carmen; Grabbe, Stephan; Vokes, Natalie; Margolis, Claire A.; Conway, Jake; He, Meng Xiao; Elmarakeby, Haitham; Dietlein, Felix; Miao, Diana; Tracy, Adam; Gogas, Helen; Goldinger, Simone M.; Utikal, Jochen; Blank, Christian U.; Rauschenberg, Ricarda; von Bubnoff, Dagmar; Krackhardt, Angela; Weide, Benjamin; Haferkamp, Sebastian; Kiecker, Felix; Izar, Ben; Garraway, Levi; Regev, Aviv; Flaherty, Keith; Paschen, Annette; Van Allen, Eliezer M.; Schadendorf, Dirk
    Author Correction: Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
    In: Nature Medicine Vol. 26 (2020) Nr. 7, pp. 1147
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk
    Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 6232
    Online Full Text: dx.doi.org/ (Open Access)
  • Cabrita, Rita; Lauss, Martin; Sanna, Adriana; Donia, Marco; Skaarup Larsen, Mathilde; Mitra, Shamik; Johansson, Iva; Phung, Bengt; Harbst, Katja; Vallon-Christersson, Johan; van Schoiack, Alison; Lövgren, Kristina; Warren, Sarah; Jirström, Karin; Olsson, Håkan; Pietras, Kristian; Ingvar, Christian; Isaksson, Karolin; Schadendorf, Dirk; Schmidt, Henrik; Bastholt, Lars; Carneiro, Ana; Wargo, Jennifer A.; Svane, Inge Marie; Jönsson, Göran
    Author Correction: Tertiary lymphoid structures improve immunotherapy and survival in melanoma
    In: Nature Vol. 580 (2020) Nr. 7801, pp. E1
    Online Full Text: dx.doi.org/ (Open Access)
  • Brenner, Ellen; Schörg, Barbara F.; Ahmetlić, Fatima; Wieder, Thomas; Hilke, Franz Joachim; Simon, Nadine; Schroeder, Christopher; Demidov, German; Riedel, Tanja; Fehrenbacher, Birgit; Schaller, Martin; Forschner, Andrea; Eigentler, Thomas; Niessner, Heike; Sinnberg, Tobias; Böhm, Katharina S.; Hömberg, Nadine; Braumüller, Heidi; Dauch, Daniel; Zwirner, Stefan; Zender, Lars; Sonanini, Dominik; Geishauser, Albert; Bauer, Jürgen; Eichner, Martin; Jarick, Katja J.; Beilhack, Andreas; Biskup, Saskia; Döcker, Dennis; Schadendorf, Dirk; Quintanilla-Martinez, Leticia; Pichler, Bernd J.; Kneilling, Manfred; Mocikat, Ralph; Röcken, Martin
    Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 1335
    Online Full Text: dx.doi.org/ (Open Access)
  • Migden, Michael R.; Khushalani, Nikhil I.; Chang, Anne Lynn S.; Lewis, Karl D.; Schmults, Chrysalyne D.; Hernandez-Aya, Leonel; Meier, Friedegund; Schadendorf, Dirk; Guminski, Alexander; Hauschild, Axel; Wong, Deborah J.; Daniels, Gregory A.; Berking, Carola; Jankovic, Vladimir; Stankevich, Elizabeth; Booth, Jocelyn; Li, Siyu; Weinreich, David M.; Yancopoulos, George D.; Lowy, Israel; Fury, Matthew G.; Rischin, Danny
    Cemiplimab in locally advanced cutaneous squamous cell carcinoma : results from an open-label, phase 2, single-arm trial
    In: The Lancet Oncology Vol. 21 (2020) Nr. 2, pp. 294 - 305
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Dummer, Reinhard; Lebbé, Celeste; Atkinson, Victoria; Mandalà, Mario; Nathan, Paul D.; Arance, Ana; Richtig, Erika; Yamazaki, Naoya; Robert, Caroline; Schadendorf, Dirk; Tawbi, Hussein A.; Ascierto, Paolo A.; Ribas, Antoni; Flaherty, Keith T.; Pakhle, Neha; Campbell, Catarina D.; Gusenleitner, Daniel; Masood, Aisha; Brase, Jan C.; Gasal, Eduard; Long, Georgina V.
    Combined PD-1, BRAF and MEK inhibition in advanced BRAF-mutant melanoma : safety run-in and biomarker cohorts of COMBI-i
    In: Nature Medicine Vol. 26 (2020) Nr. 10, pp. 1557 - 1563
    Online Full Text: dx.doi.org/
  • Küppers, Ralf; Schadendorf, Dirk; Shuai, Shimin; Stein, Lincoln D.
    Combined burden and functional impact tests for cancer driver discovery using DriverPower
    In: Nature Communications Vol. 11 (2020) 734
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Bristow, Robert G.; Boutros, Paul C.; PCAWG Consortium
    Divergent mutational processes distinguish hypoxic and normoxic tumours
    In: Nature Communications Vol. 11 (2020) 737
    Online Full Text: dx.doi.org/ (Open Access)
  • Ugurel, Selma; Schadendorf, Dirk; Horny, K.; Sucker, Antje; Schramm, Sabine; Utikal, Jochen; Pföhler, Claudia; Herbst, Rudolf A.; Schilling, B.; Blank, Christian U.; Becker, Jürgen; Paschen, Annette; Zimmer, Lisa; Livingstone, Elisabeth; Horn, Peter; Rebmann, Vera
    Elevated baseline serum PD-1 or PD-L1 predicts poor outcome of PD-1 inhibition therapy in metastatic melanoma
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    Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility
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    Genomic footprints of activated telomere maintenance mechanisms in cancer
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    High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
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    Inferring structural variant cancer cell fraction
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    Integrated molecular drivers coordinate biological and clinical states in melanoma
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    Integrative pathway enrichment analysis of multivariate omics data
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    Metabolic heterogeneity confers differences in melanoma metastatic potential
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    Pan-cancer analysis of whole genomes
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    Pathway and network analysis of more than 2500 whole cancer genomes
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    Prognostic impact of baseline tumour immune infiltrate on disease-free survival in patients with completely resected, BRAFv⁶⁰⁰ mutation–positive melanoma receiving adjuvant vemurafenib
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    Rationale for Immune Checkpoint Inhibitors plus Targeted Therapy in Metastatic Melanoma : A Review
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    Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
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    Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
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    Sex differences in oncogenic mutational processes
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    Tertiary lymphoid structures improve immunotherapy and survival in melanoma
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    Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
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    Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF melanoma (PACMEL) : a multicentre, open-label, randomised, controlled phase II trial
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    Patient-reported outcomes in patients with resected, high-risk melanoma with BRAFV600E or BRAFV600K mutations treated with adjuvant dabrafenib plus trametinib (COMBI-AD) : a randomised, placebo-controlled, phase 3 trial
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    Publisher Correction : Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
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    Publisher Correction: Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
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    Survival Outcomes in Patients with Previously Untreated BRAF Wild-Type Advanced Melanoma Treated with Nivolumab Therapy : Three-Year Follow-up of a Randomized Phase 3 Trial
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    Treatment in metastatic melanoma : Time to re-think
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    A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
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    Adjuvant melanoma therapy with new drugs : Should physicians continue to focus on metastatic disease or use it earlier in primary melanoma?
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    Adjuvant vemurafenib in resected, BRAF mutation-positive melanoma (BRIM8) : a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial
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    Adverse events (AEs) over time in patients (pts) treated with adjuvant dabrafenib plus trametinib (D + T) or placebo (Pbo) in the COMBI-AD trial
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    Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy : a retrospective, multicohort analysis
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    Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade
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    Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS) : a multicentre, open-label, randomised phase 3 trial
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    Estimate of long-term relapse-free survival (RFS) and analysis of baseline factors associated with RFS in the COMBI-AD trial
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    Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors
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    Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067) : 4-year outcomes of a multicentre, randomised, phase 3 trial
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    Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
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    Overall survival at 4 years of follow-up in a phase III trial of nivolumab plus ipilimumab combination therapy in advanced melanoma (CheckMate 067)
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