ZMB Member Dirk Schadendorf

ZMB Member
Dirk Schadendorf

Next ZMB-Member
Dirk Schadendorf portrait
© UKE

Prof. Dr. Dirk Schadendorf

Director of:

Clinic for Dermatology

University Hospital Essen
Hufelandstraße 55
45147 Essen

Research Overview

  • Malignant melanoma
  • Merkel cell carcinoma
  • Squamous cell carcinoma
  • Basal cell carcinoma
  • Mycosis Fungoides/Sezary syndrome (T-Zell-Non-Hodgkin-Lymphoma)
  • Application observation

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Selected Publications

    Journal articles

  • Bottomley, Andrew; Coens, Corneel; Mierzynska, Justyna; Blank, Christian U; Mandalà, Mario; Long, Georgina V; Atkinson, Victoria G; Dalle, Stéphane; Haydon, Andrew M; Meshcheryakov, Andrey; Khattak, Adnan; Carlino, Matteo S; Sandhu, Shahneen; Puig, Susana; Ascierto, Paolo A; Larkin, James; Lorigan, Paul C; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Di Giacomo, Anna Maria; van den Eertwegh, Alfonsus J M; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; van Akkooi, Alexander C J; Krepler, Clemens; Ibrahim, Nageatte; Marreaud, Sandrine; Kicinski, Michal; Suciu, Stefan; Robert, Caroline; Eggermont, Alexander M M; Lesimple, Thierry; Maio, Michele; Linette, Gerald; Mortier, Laurent; Svane, Inge Marie; Schachter, Jacob; Brown, Michael; Hersey, Peter; Barrow, Catherine; Kudchadkar, Ragini; Dutriaux, Caroline; Song, Xinni; Quaglino, Pietro; Queirolo, Paola; Meier, Friedegund; Stroyakovskiy, Daniil; Guillot, Bernard; Romero, Pablo Luis Ortiz; Bastholt, Lars; Garbe, Claus; Grange, Florent; Mohr, Peter; Algazi, Alain; Bechter, Oliver; Hernberg, Micaela; Loquai, Carmen; Meiss, Frank; Chiarion Sileni, Vanna; Bar-Sela, Gil; Fitzharris, Bernard; Saiag, Philippe; Arnault, Jean-Philippe; Simon, Jan-Christoph; Stephens, Rosalie; Baurain, Jean-Francois; Lebbe, Célèste; Combemale, Patrick; Dummer, Reinhard; Hauschild, Axel; Parente, Phillip; Yamazaki, Naoya; Milhem, Mohammed; Leccia, Marie-Thérèse; Geoffrois, Lionel; Kretschmer, Lutz; Dunwoodie, Elaine; Walker, John; Lotem, Michal; Hendler, Daniel; Mackiewicz, Andrzej; Sekulovic, Lidija; Dzienis, Marcin; Hospers, Geke A.P.; Siano, Marco; Hassel, Jessica; Corrie, Philippa; Passos, Maria-Jose; Levin, Max; Hoeller, Christoph; Machet, Laurent; Hallmeyer, Sigrun; Waterston, Ashita; Descamps, Vincent; Kiecker, Felix; Aarts, Maureen; Schmidt, Henrik; Raimundo, Ana; Nyakas, Marta; Lacour, Jean-Philippe; Berking, Carola; Ferrucci, Pier Francesco; Jameson, Michael; Kim, Kevin; Yokota, Kenji; Kerger, Joseph; Aubin, François; Groenewegen, Gerard; Kapiteijn, Helena; Boehncke, Wolf-Henning; Utikal, Jochen; Casasola, Richard; Marshall, Ernest; Ferraresi, Virginia; Richtig, Erika; Matkovic, Suzana; Inozume, Takashi; Crook, Timothy; McNeil, Catriona; Kiyohara, Yoshio; Avril, Marie-Francoise; Hein, Rüdiger; Terheyden, Patrick; Nathan, Paul; Aoi, Jun; Skytta, Tanja; Jouary, Thomas; Takenouchi, Tatsuya; Straume, Oddbjorn; Martins, César; Mukhametshina, Guzel
    Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial
    In: The Lancet Oncology Vol. 22 (2021) Nr. 5, pp. 655 - 664
    ISSN: 1474-5488; 1470-2045
    Online Full Text: dx.doi.org/
  • Eggermont, Alexander M M; Blank, Christian U; Mandalà, Mario; Long, Georgina V; Atkinson, Victoria G; Dalle, Stéphane; Haydon, Andrew M; Meshcheryakov, Andrey; Khattak, Adnan; Carlino, Matteo S; Sandhu, Shahneen; Larkin, James; Puig, Susana; Ascierto, Paolo A; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Di Giacomo, Anna Maria; van den Eertwegh, Alfonsus J M; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; Lorigan, Paul C; van Akkooi, Alexander C J; Krepler, Clemens; Ibrahim, Nageatte; Marreaud, Sandrine; Kicinski, Michal; Suciu, Stefan; Robert, Caroline; Menzies, Alex; Lesimple, Thierry; Maio, Michele; Linette, Gerald; Brown, Michael; Hersey, Peter; Svane, Inge Marie; Mortier, Laurent; Schachter, Jacob; Barrow, Catherine; Kudchadkar, Ragini; Song, Xinni; Dutriaux, Caroline; Quaglino, Pietro; Meier, Friedegund; Queirolo, Paola; Stroyakovskiy, Daniil; Bastholt, Lars; Guillot, Bernard; Garbe, Claus; Ortiz Romero, Pablo Luis; Grange, Florent; Mohr, Peter; Algazi, Alain; Bechter, Oliver; Hernberg, Micaela; Arnault, Jean-Philippe; Saiag, Philippe; Loquai, Carmen; Meiss, Frank; Simon, Jan-Christoph; Bar-Sela, Gil; Chiarion Sileni, Vanna; Fitzharris, Bernard; McCrystal, Mike; Parente, Phillip; Baurain, Jean-Francois; Combemale, Patrick; Lebbe, Célèste; Hauschild, Axel; Yamazaki, Naoya; Dummer, Reinhard; Milhem, Mohammed; Dzienis, Marcin; Walker, John; Geoffrois, Lionel; Leccia, Marie-Thérèse; Kretschmer, Lutz; Hendler, Daniel; Lotem, Michal; Mackiewicz, Andrzej; Sekulovic, Lidija; Dunwoodie, Elaine; Hoeller, Christoph; Machet, Laurent; Hassel, Jessica; Hospers, Geke A.P.; Passos, Maria-Jose; Levin, Max; Fehr, Martin; Corrie, Philippa; Waterston, Ashita; Hallmeyer, Sigrun; Schmidt, Henrik; Descamps, Vincent; Lacour, Jean-Philippe; Berking, Carola; Kiecker, Felix; Ferrucci, Pier Francesco; Yokota, Kenji; Aarts, Maureen; Jameson, Michael; Winge-Main, Anna Katharina; Ferreira, Paula; Kim, Kevin; McNeil, Catriona; Hofmann-Wellenhof, Reiner; Kerger, Joseph; Aubin, François; Utikal, Jochen; Ferraresi, Virginia; Inozume, Takashi; Kiyohara, Yoshio; Groenewegen, Gerard; Kapiteijn, Helena; Matkovic, Suzana; Boehncke, Wolf-Henning; Casasola, Richard; Crook, Timothy; Marshall, Ernest; Skytta, Tanja; Avril, Marie-Francoise; Jouary, Thomas; Hein, Rüdiger; Terheyden, Patrick; Aoi, Jun; Takenouchi, Tatsuya; Straume, Oddbjorn; Martins, César; Mukhametshina, Guzel; Nathan, Paul
    Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : distant metastasis-free survival results from a double-blind, randomised, controlled, phase 3 trial
    In: The Lancet Oncology Vol. 22 (2021) Nr. 5, pp. 643 - 654
    ISSN: 1474-5488; 1470-2045
    Online Full Text: dx.doi.org/
  • Syeda, Mahrukh M.; Wiggins, Jennifer M.; Corless, Broderick C; Long, Georgina V.; Flaherty, Keith T.; Schadendorf, Dirk; Nathan, Paul D.; Robert, Caroline; Ribas, Antoni; Davies, Michael A.; Grob, Jean Jacques; Gasal, Eduard; Squires, Matthew; Marker, Mahtab; Garrett, James; Brase, Jan C.; Polsky, David
    Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib : A clinical validation study
    In: The Lancet Oncology Vol. 22 (2021) Nr. 3, pp. 370 - 380
    ISSN: 1470-2045; 1474-5488
    Online Full Text: dx.doi.org/
  • Le Rhun, E.; Guckenberger, M.; Smits, M.; Dummer, R.; Bachelot, T.; Sahm, F.; Galldiks, N.; de Azambuja, E.; Berghoff, A.S.; Metellus, P.; Peters, S.; Hong, Y.-K.; Winkler, F.; Schadendorf, Dirk; van den Bent, M.; Seoane, J.; Stahel, R.; Minniti, G.; Wesseling, P.; Weller, M.; Preusser, M.
    EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours
    In: Annals of Oncology Vol. 32 (2021) Nr. 11, pp. 1332 - 1347
    ISSN: 0923-7534; 1569-8041
    Online Full Text: dx.doi.org/ (Open Access)
  • Frangieh, Chris J.; Melms, Johannes C.; Thakore, Pratiksha I.; Geiger-Schuller, Kathryn R.; Ho, Patricia; Luoma, Adrienne M.; Cleary, Brian; Jerby-Arnon, Livnat; Malu, Shruti; Cuoco, Michael S.; Zhao, Maryann; Ager, Casey R.; Rogava, Meri; Hovey, Lila; Rotem, Asaf; Bernatchez, Chantale; Wucherpfennig, Kai W.; Johnson, Bruce E.; Rozenblatt-Rosen, Orit; Schadendorf, Dirk; Regev, Aviv; Izar, Benjamin
    Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion
    In: Nature Genetics Vol. 53 (2021) Nr. 3, pp. 332 - 341
    ISSN: 1061-4036; 1546-1718
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
  • Dummer, Reinhard; Brase, Jan C.; Garrett, James; Campbell, Catarina D.; Gasal, Eduard; Squires, Matthew; Gusenleitner, Daniel; Santinami, Mario; Atkinson, Victoria; Mandalà, Mario; Chiarion-Sileni, Vanna; Flaherty, Keith; Larkin, James; Robert, Caroline; Kefford, Richard; Kirkwood, John M.; Hauschild, Axel; Schadendorf, Dirk; Long, Georgina V.
    Adjuvant dabrafenib plus trametinib versus placebo in patients with resected, BRAFV⁶⁰⁰-mutant, stage III melanoma (COMBI-AD) : Exploratory biomarker analyses from a randomised, phase 3 trial
    In: The Lancet Oncology Vol. 21 (2020) Nr. 3, pp. 358 - 372
    ISSN: 1474-5488; 1470-2045
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Zimmer, Lisa; Livingstone, Elisabeth; Hassel, Jessica C.; Fluck, Michael; Eigentler, Thomas; Loquai, Carmen; Haferkamp, Sebastian; Gutzmer, Ralf; Meier, Friedegund; Mohr, Peter; Hauschild, Axel; Schilling, Bastian; Menzer, Christian; Kieker, Felix; Dippel, Edgar; Rösch, Alexander; Simon, Jan-Christoph; Conrad, Beate; Körner, Silvia; Windemuth-Kieselbach, Christine; Schwarz, Leonora; Garbe, Claus; Becker, Jürgen C.; Schadendorf, Dirk; Berking, Carola; Herbst, Rudolf A.; Martens, Uwe M; Sell, Sabine; Stadler, Rudolf; Terheyden, Patrick; Utikal, Jochen
    Adjuvant nivolumab plus ipilimumab or nivolumab monotherapy versus placebo in patients with resected stage IV melanoma with no evidence of disease (IMMUNED) : a randomised, double-blind, placebo-controlled, phase 2 trial
    In: The Lancet Vol. 395 (2020) Nr. 10236, pp. 1558 - 1568
    ISSN: 1474-547X; 0140-6736
    Online Full Text: dx.doi.org/
  • Eggermont, Alexander M. M.; Kicinski, Michal; Blank, Christian U.; Mandala, Mario; Long, Georgina V.; Atkinson, Victoria; Dalle, Stéphane; Haydon, Andrew; Khattak, Adnan; Carlino, Matteo S.; Sandhu, Shahneen; Larkin, James; Puig, Susana; Ascierto, Paolo A.; Rutkowski, Piotr; Schadendorf, Dirk; Koornstra, Rutger; Hernandez-Aya, Leonel; Di Giacomo, Anna Maria; Van Den Eertwegh, Alfonsus J. M.; Grob, Jean-Jacques; Gutzmer, Ralf; Jamal, Rahima; Lorigan, Paul C.; Krepler, Clemens; Ibrahim, Nageatte; Marreaud, Sandrine; Van Akkooi, Alexander; Robert, Caroline; Suciu, Stefan
    Association between Immune-Related Adverse Events and Recurrence-Free Survival among Patients with Stage III Melanoma Randomized to Receive Pembrolizumab or Placebo : A Secondary Analysis of a Randomized Clinical Trial
    In: JAMA Oncology Vol. 6 (2020) Nr. 4, pp. 519 - 527
    ISSN: 2374-2445; 2374-2437
    Online Full Text: dx.doi.org/ (Open Access)
  • Puzanov, Igor; Ribas, Antoni; Robert, Caroline; Schachter, Jacob; Nyakas, Marta; Daud, Adil; Arance, Ana; Carlino, Matteo S.; O'Day, Steven J.; Long, Georgina V.; Margolin, Kim A.; Dummer, Reinhard; Schadendorf, Dirk; Lutzky, Jose; Ascierto, Paolo A.; Tarhini, Ahmad; Lin, Jianxin; Mogg, Robin; Homet Moreno, Blanca; Ibrahim, Nageatte; Hamid, Omid
    Association of BRAF V600E/K Mutation Status and Prior BRAF/MEK Inhibition with Pembrolizumab Outcomes in Advanced Melanoma : Pooled Analysis of 3 Clinical Trials
    In: JAMA Oncology Vol. 6 (2020) Nr. 8, pp. 1256 - 1264
    ISSN: 2374-2445; 2374-2437
    Online Full Text: dx.doi.org/ (Open Access)
  • Liu, David; Schilling, Bastian; Liu, Derek; Sucker, Antje; Livingstone, Elisabeth; Jerby-Arnon, Livnat; Zimmer, Lisa; Gutzmer, Ralf; Satzger, Imke; Loquai, Carmen; Grabbe, Stephan; Vokes, Natalie; Margolis, Claire A.; Conway, Jake; He, Meng Xiao; Elmarakeby, Haitham; Dietlein, Felix; Miao, Diana; Tracy, Adam; Gogas, Helen; Goldinger, Simone M.; Utikal, Jochen; Blank, Christian U.; Rauschenberg, Ricarda; von Bubnoff, Dagmar; Krackhardt, Angela; Weide, Benjamin; Haferkamp, Sebastian; Kiecker, Felix; Izar, Ben; Garraway, Levi; Regev, Aviv; Flaherty, Keith; Paschen, Annette; Van Allen, Eliezer M.; Schadendorf, Dirk
    Author Correction: Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
    In: Nature Medicine Vol. 26 (2020) Nr. 7, pp. 1147
    ISSN: 1546-170X; 1078-8956
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk
    Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 6232
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Cabrita, Rita; Lauss, Martin; Sanna, Adriana; Donia, Marco; Skaarup Larsen, Mathilde; Mitra, Shamik; Johansson, Iva; Phung, Bengt; Harbst, Katja; Vallon-Christersson, Johan; van Schoiack, Alison; Lövgren, Kristina; Warren, Sarah; Jirström, Karin; Olsson, Håkan; Pietras, Kristian; Ingvar, Christian; Isaksson, Karolin; Schadendorf, Dirk; Schmidt, Henrik; Bastholt, Lars; Carneiro, Ana; Wargo, Jennifer A.; Svane, Inge Marie; Jönsson, Göran
    Author Correction: Tertiary lymphoid structures improve immunotherapy and survival in melanoma
    In: Nature Vol. 580 (2020) Nr. 7801, pp. E1
    ISSN: 1476-4687; 0028-0836
    Online Full Text: dx.doi.org/ (Open Access)
  • Brenner, Ellen; Schörg, Barbara F.; Ahmetlić, Fatima; Wieder, Thomas; Hilke, Franz Joachim; Simon, Nadine; Schroeder, Christopher; Demidov, German; Riedel, Tanja; Fehrenbacher, Birgit; Schaller, Martin; Forschner, Andrea; Eigentler, Thomas; Niessner, Heike; Sinnberg, Tobias; Böhm, Katharina S.; Hömberg, Nadine; Braumüller, Heidi; Dauch, Daniel; Zwirner, Stefan; Zender, Lars; Sonanini, Dominik; Geishauser, Albert; Bauer, Jürgen; Eichner, Martin; Jarick, Katja J.; Beilhack, Andreas; Biskup, Saskia; Döcker, Dennis; Schadendorf, Dirk; Quintanilla-Martinez, Leticia; Pichler, Bernd J.; Kneilling, Manfred; Mocikat, Ralph; Röcken, Martin
    Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 1335
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Migden, Michael R.; Khushalani, Nikhil I.; Chang, Anne Lynn S.; Lewis, Karl D.; Schmults, Chrysalyne D.; Hernandez-Aya, Leonel; Meier, Friedegund; Schadendorf, Dirk; Guminski, Alexander; Hauschild, Axel; Wong, Deborah J.; Daniels, Gregory A.; Berking, Carola; Jankovic, Vladimir; Stankevich, Elizabeth; Booth, Jocelyn; Li, Siyu; Weinreich, David M.; Yancopoulos, George D.; Lowy, Israel; Fury, Matthew G.; Rischin, Danny
    Cemiplimab in locally advanced cutaneous squamous cell carcinoma : results from an open-label, phase 2, single-arm trial
    In: The Lancet Oncology Vol. 21 (2020) Nr. 2, pp. 294 - 305
    ISSN: 1474-5488; 1470-2045
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Dummer, Reinhard; Lebbé, Celeste; Atkinson, Victoria; Mandalà, Mario; Nathan, Paul D.; Arance, Ana; Richtig, Erika; Yamazaki, Naoya; Robert, Caroline; Schadendorf, Dirk; Tawbi, Hussein A.; Ascierto, Paolo A.; Ribas, Antoni; Flaherty, Keith T.; Pakhle, Neha; Campbell, Catarina D.; Gusenleitner, Daniel; Masood, Aisha; Brase, Jan C.; Gasal, Eduard; Long, Georgina V.
    Combined PD-1, BRAF and MEK inhibition in advanced BRAF-mutant melanoma : safety run-in and biomarker cohorts of COMBI-i
    In: Nature Medicine Vol. 26 (2020) Nr. 10, pp. 1557 - 1563
    ISSN: 1546-170X; 1078-8956
    Online Full Text: dx.doi.org/
  • Ugurel, Selma; Schadendorf, Dirk; Horny, K.; Sucker, Antje; Schramm, Sabine; Utikal, Jochen; Pföhler, Claudia; Herbst, Rudolf A.; Schilling, B.; Blank, Christian U.; Becker, Jürgen; Paschen, Annette; Zimmer, Lisa; Livingstone, Elisabeth; Horn, Peter; Rebmann, Vera
    Elevated baseline serum PD-1 or PD-L1 predicts poor outcome of PD-1 inhibition therapy in metastatic melanoma
    In: Annals of Oncology Vol. 31 (2020) Nr. 1, pp. 144 - 152
    ISSN: 1569-8041; 0923-7534
    Online Full Text: dx.doi.org/ (Open Access)
  • Dummer, R.; Hauschild, A.; Santinami, M.; Atkinson, V.; MandalÃ, M.; Kirkwood, J.M.; Sileni, V. Chiarion; Larkin, J.; Nyakas, M.; Dutriaux, C.; Haydon, A.; Robert, C.; Mortier, L.; Schachter, J.; Lesimple, T.; Plummer, R.; Dasgupta, K.; Gasal, E.; Tan, M.; Long, G.V.; Schadendorf, Dirk
    Five-Year Analysis of Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma
    In: New England Journal of Medicine Vol. 383 (2020) Nr. 12, pp. 1139 - 1148
    ISSN: 1533-4406; 0028-4793
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Landi, Maria Teresa; Bishop, D. Timothy; MacGregor, Stuart; Machiela, Mitchell J.; Stratigos, Alexander J.; Ghiorzo, Paola; Brossard, Myriam; Calista, Donato; Choi, Jiyeon; Fargnoli, Maria Concetta; Zhang, Tongwu; Rodolfo, Monica; Trower, Adam J.; Menin, Chiara; Martinez, Jacobo; Hadjisavvas, Andreas; Song, Lei; Stefanaki, Irene; Scolyer, Richard; Yang, Rose; Goldstein, Alisa M.; Potrony, Miriam; Kypreou, Katerina P.; Pastorino, Lorenza; Queirolo, Paola; Pellegrini, Cristina; Cattaneo, Laura; Zawistowski, Matthew; Gimenez-Xavier, Pol; Rodriguez, Arantxa; Elefanti, Lisa; Manoukian, Siranoush; Rivoltini, Licia; Smith, Blair H.; Loizidou, Maria A.; Del Regno, Laura; Massi, Daniela; Mandala, Mario; Khosrotehrani, Kiarash; Akslen, Lars A.; Amos, Christopher I.; Andresen, Per A.; Avril, Marie-Françoise; Azizi, Esther; Soyer, H. Peter; Bataille, Veronique; Dalmasso, Bruna; Bowdler, Lisa M.; Burdon, Kathryn P.; Chen, Wei V.; Codd, Veryan; Craig, Jamie E.; Dębniak, Tadeusz; Falchi, Mario; Fang, Shenying; Friedman, Eitan; Simi, Sarah; Galan, Pilar; Garcia-Casado, Zaida; Gillanders, Elizabeth M.; Gordon, Scott; Green, Adele; Gruis, Nelleke A.; Hansson, Johan; Harland, Mark; Harris, Jessica; Helsing, Per; Henders, Anjali; Hočevar, Marko; Höiom, Veronica; Hunter, David; Ingvar, Christian; Kumar, Rajiv; Lang, Julie; Lathrop, G. Mark; Lee, Jeffrey E.; Li, Xin; Lubiński, Jan; Mackie, Rona M.; Malt, Maryrose; Malvehy, Josep; McAloney, Kerrie; Mohamdi, Hamida; Molven, Anders; Moses, Eric K.; Neale, Rachel E.; Novaković, Srdjan; Nyholt, Dale R.; Olsson, Håkan; Orr, Nicholas; Fritsche, Lars G.; Puig-Butille, Joan Anton; Qureshi, Abrar A.; Radford-Smith, Graham L.; Randerson-Moor, Juliette; Requena, Celia; Rowe, Casey; Samani, Nilesh J.; Sanna, Marianna; Schadendorf, Dirk; Schulze, Hans-Joachim; Simms, Lisa A.; Smithers, Mark; Song, Fengju; Swerdlow, Anthony J.; van der Stoep, Nienke; Kukutsch, Nicole A.; Visconti, Alessia; Wallace, Leanne; Ward, Sarah V.; Wheeler, Lawrie; Sturm, Richard A.; Hutchinson, Amy; Jones, Kristine; Malasky, Michael; Vogt, Aurelie; Zhou, Weiyin; Pooley, Karen A.; Elder, David E.; Han, Jiali; Hicks, Belynda; Hayward, Nicholas K.; Kanetsky, Peter A.; Brummett, Chad; Montgomery, Grant W.; Olsen, Catherine M.; Hayward, Caroline; Dunning, Alison M.; Martin, Nicholas G.; Evangelou, Evangelos; Mann, Graham J.; Long, Georgina; Pharoah, Paul D. P.; Easton, Douglas F.; Barrett, Jennifer H.; Cust, Anne E.; Abecasis, Goncalo; Duffy, David L.; Whiteman, David C.; Gogas, Helen; De Nicolo, Arcangela; Tucker, Margaret A.; Newton-Bishop, Julia A.; Peris, Ketty; Chanock, Stephen J.; Demenais, Florence; Brown, Kevin M.; Puig, Susana; Nagore, Eduardo; Shi, Jianxin; Iles, Mark M.; Law, Matthew H.
    Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility
    In: Nature Genetics Vol. 52 (2020) Nr. 5, pp. 494 - 504
    ISSN: 1546-1718; 1061-4036
    Online Full Text: dx.doi.org/
  • Conway, Jake R.; Dietlein, Felix; Taylor-Weiner, Amaro; AlDubayan, Saud; Vokes, Natalie; Keenan, Tanya; Reardon, Brendan; He, Meng Xiao; Margolis, Claire A.; Weirather, Jason L.; Haq, Rizwan; Schilling, Bastian; Stephen Hodi, F.; Schadendorf, Dirk; Liu, David; Van Allen, Eliezer M.
    Integrated molecular drivers coordinate biological and clinical states in melanoma
    In: Nature Genetics Vol. 52 (2020) Nr. 12, pp. 1373 - 1383
    ISSN: 1546-1718; 1061-4036
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Tasdogan, Alpaslan; Faubert, Brandon; Ramesh, Vijayashree; Ubellacker, Jessalyn M.; Shen, Bo; Solmonson, Ashley; Murphy, Malea M.; Gu, Zhimin; Gu, Wen; Martin, Misty; Kasitinon, Stacy Y.; Vandergriff, Travis; Mathews, Thomas P.; Zhao, Zhiyu; Schadendorf, Dirk; DeBerardinis, Ralph J.; Morrison, Sean J.
    Metabolic heterogeneity confers differences in melanoma metastatic potential
    In: Nature Vol. 577 (2020) Nr. 7788, pp. 115 - 120
    ISSN: 1476-4687; 0028-0836
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium; et al.
    Pan-cancer analysis of whole genomes
    In: Nature Vol. 578 (2020) Nr. 7793, pp. 82 - 93
    ISSN: 0028-0836; 1476-4687
    Online Full Text: dx.doi.org/ (Open Access)
  • Ascierto, P.A.; Lewis, K.D.; Di Giacomo, A.M.; Demidov, L.; Mandalà, M.; Bondarenko, I.; Herbert, C.; Mackiewicz, A.; Rutkowski, P.; Guminski, A.; Simmons, B.; Ye, C.; Hooper, G.; Wongchenko, M.J.; Goodman, G.R.; Yan, Y.; Schadendorf, Dirk
    Prognostic impact of baseline tumour immune infiltrate on disease-free survival in patients with completely resected, BRAFv⁶⁰⁰ mutation–positive melanoma receiving adjuvant vemurafenib
    In: Annals of Oncology Vol. 31 (2020) Nr. 1, pp. 153 - 159
    ISSN: 1569-8041; 0923-7534
    Online Full Text: dx.doi.org/ (Open Access)
  • Dummer, Reinhard; Ascierto, Paolo A.; Nathan, Paul; Robert, Caroline; Schadendorf, Dirk
    Rationale for Immune Checkpoint Inhibitors plus Targeted Therapy in Metastatic Melanoma : A Review
    In: JAMA Oncology Vol. 6 (2020) Nr. 12, pp. 1957 - 1966
    ISSN: 2374-2445; 2374-2437
    Online Full Text: dx.doi.org/
  • Küppers, Ralf; Schadendorf, Dirk
    Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4748
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; PCAWG Tumour Subtypes and Clinical Translation; PCAWG Consortium
    Sex differences in oncogenic mutational processes
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4330
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Cabrita, Rita; Lauss, Martin; Sanna, Adriana; Donia, Marco; Larsen, Mathilde; Schadendorf, Dirk
    Tertiary lymphoid structures improve immunotherapy and survival in melanoma
    In: Nature Vol. 577 (2020) Nr. 7791, pp. 561 - 565
    ISSN: 0028-0836; 1476-4687
    Online Full Text: dx.doi.org/
  • Liu, David; Schilling, Bastian; Liu, Derek; Sucker, Antje; Livingstone, Elisabeth; Jerby-Amon, Livnat; Zimmer, Lisa; Gutzmer, Ralf; Satzger, Imke; Loquai, Carmen; Grabbe, Stephan; Vokes, Natalie; Margolis, Claire A.; Conway, Jake; He, Meng Xiao; Elmarakeby, Haitham; Dietlein, Felix; Miao, Diana; Tracy, Adam; Gogas, Helen; Goldinger, Simone M.; Utikal, Jochen; Blank, Christian U.; Rauschenberg, Ricarda; Bubnoff, Dagmar von; Krackhardt, Angela; Weide, Benjamin; Haferkamp, Sebastian; Kiecker, Felix; Izar, Ben; Garraway, Levi; Regev, Aviv; Flaherty, Keith; Paschen, Annette; Allen, Eliezer M. van; Schadendorf, Dirk
    Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
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    Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF melanoma (PACMEL) : a multicentre, open-label, randomised, controlled phase II trial
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    Patient-reported outcomes in patients with resected, high-risk melanoma with BRAFV600E or BRAFV600K mutations treated with adjuvant dabrafenib plus trametinib (COMBI-AD) : a randomised, placebo-controlled, phase 3 trial
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    Publisher Correction : Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
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    Survival Outcomes in Patients with Previously Untreated BRAF Wild-Type Advanced Melanoma Treated with Nivolumab Therapy : Three-Year Follow-up of a Randomized Phase 3 Trial
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    Treatment in metastatic melanoma : Time to re-think
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    Adjuvant melanoma therapy with new drugs : should physicians continue to focus on metastatic disease or use it earlier in primary melanoma?
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    Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy : a retrospective, multicohort analysis
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    Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade
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    Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS) : a multicentre, open-label, randomised phase 3 trial
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    Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors
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    Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067) : 4-year outcomes of a multicentre, randomised, phase 3 trial
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    Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
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    Overall survival in patients with BRAF-mutant melanoma receiving encorafenib plus binimetinib versus vemurafenib or encorafenib (COLUMBUS) : a multicentre, open-label, randomised, phase 3 trial
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    Acquired IFNγ 3 resistance impairs anti-Tumor immunity and gives rise to T-cell-resistant melanoma lesions
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    Efficacy and safety of nilotinib in patients with kit-mutated metastatic or inoperable melanoma : Final results from the global, single-arm, phase ii team trial
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    Ipilimumab 10 mg/kg versus ipilimumab 3 mg/kg in patients with unresectable or metastatic melanoma : a randomised, double-blind, multicentre, phase 3 trial
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    Nivolumab for Patients With Advanced Melanoma Treated Beyond Progression : Analysis of 2 Phase 3 Clinical Trials
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    Predictors of responses to immune checkpoint blockade in advanced melanoma
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    Two intermittent vismodegib dosing regimens in patients with multiple basal-cell carcinomas (MIKIE) : a randomised, regimen-controlled, double-blind, phase 2 trial
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    Vemurafenib in metastatic melanoma patients with brain metastases : An open-label, single-arm, phase 2, multicentre study
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    A phase I, open-label study of pasireotide in patients with BRAF- and NRAS-wild type, unresectable and or metastatic melanoma
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    Adjuvant treatment with pegylated interferon ?-2a versus low-dose interferon ?-2a in patients with high-risk melanoma : a randomized phase III DeCOG trial
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    Checkpoint inhibitors : a new standard of care for advanced Merkel cell carcinoma?
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    Evaluation of the pharmacokinetic (PK) profile of vismodegib (VISMO) in patients (pts) with multiple basal cell carcinomas (BCCs) across two intermittent treatment regimens in the MIKIE study
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    Factors predictive of response, disease progression, and overall survival after dabrafenib and trametinib combination treatment : a pooled analysis of individual patient data from randomised trials
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    Final overall survival for KEYNOTE-002 : pembrolizumab (pembro) versus investigator-choice chemotherapy (chemo) for ipilimumab (ipi)-refractory melanoma
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    Health-related quality-of-life (HRQOL) impact of dabrafenib (D) and trametinib (T) vs BRAF inhibitor (BRAFi) monotherapy by lactate dehydrogenase (LDH) in patients (pts) with BRAF V600–mutant melanoma
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    PD-L1 expression as a biomarker for nivolumab (NIVO) plus ipilimumab (IPI) and NIVO alone in advanced melanoma (MEL) : A pooled analysis
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    Three-year estimate of overall survival in COMBI-v, a randomized phase 3 study evaluating first-line dabrafenib (D) + trametinib (T) in patients (pts) with unresectable or metastatic BRAF V600E/K–mutant cutaneous melanoma
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    Comparison of dabrafenib and trametinib combination therapy with vemurafenib monotherapy on health-related quality of life in patients with unresectable or metastatic cutaneous BRAF Val600-mutation-positive melanoma (COMBI-v) : results of a phase 3, open-label, randomised trial
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    Disease kinetics for decision-making in advanced melanoma : a call for scenario-driven strategy trials
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    Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
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    Genomic Classification of Cutaneous Melanoma
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    Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002) : a randomised, controlled, phase 2 trial
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    Radiosensitization by BRAF inhibitor therapy-mechanism and frequency of toxicity in melanoma patients
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    Reply to the letters to the editor ‘Differential influence of vemurafenib and dabrafenib on patients' lymphocytes despite similar clinical efficacy in melanoma’ by Diwakar et al.
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    Differential influence of vemurafenib and dabrafenib on patients' lymphocytes despite similar clinical efficacy in melanoma
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    Functional and symptom impact of trametinib versus chemotherapy in BRAF V600E advanced or metastatic melanoma : Quality-of-life analyses of the METRIC study
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    Hepatic intra-arterial versus intravenous fotemustine in patients with liver metastases from uveal melanoma (EORTC 18021) : A multicentric randomized trial
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    Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3) : extended follow-up of a phase 3, randomised, open-label study
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    ISSN: 1470-2045; 1474-5488
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    Surrogate endpoints for overall survival in metastatic melanoma: A meta-analysis of randomised controlled trials
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    Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma
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    MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: A non-randomised, open-label phase 2 study
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    Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma : A phase 2 double-blind randomised study
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    Advances and perspectives in immunotherapy of melanoma
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    Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB) : A multicentre, open-label, phase 2 trial
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    Sorafenib and pegylated interferon-α2b in advanced metastatic melanoma : A multicenter phase II DeCOG trial
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    Ipilimumab monotherapy in patients with pretreated advanced melanoma : a randomised, double-blind, multicentre, phase 2, dose-ranging study
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