ZMB Member Dirk Schadendorf
ZMB Member
Dirk Schadendorf
Next ZMB-Member
Prof. Dr. Dirk Schadendorf
Director of:
Clinic for Dermatology
University Hospital Essen
Hufelandstraße 55
45147 Essen
- +49 201 723 4342
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- Press Releases
- Selected Publications
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- Publication Metrics
- ZMB Research Program
Oncology
Research Overview
- Malignant melanoma
- Merkel cell carcinoma
- Squamous cell carcinoma
- Basal cell carcinoma
- Mycosis Fungoides/Sezary syndrome (T-Zell-Non-Hodgkin-Lymphoma)
- Application observation
Selected Publications
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Adjuvant nivolumab and relatlimab in stage III/IV melanoma : the randomized phase 3 RELATIVITY-098 trialIn: Nature Medicine, 2025, in pressDOI (Open Access)
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Clinical validation of droplet digital PCR assays in detecting BRAFV⁶⁰⁰-mutant circulating tumour DNA as a prognostic biomarker in patients with resected stage III melanoma receiving adjuvant therapy (COMBI-AD) : A biomarker analysis from a double-blind, randomised phase 3 trialIn: The Lancet Oncology, Vol. 26, 2025, Nr. 5, pp. 641 – 653
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Constitutive expression of the transcriptional co-activator IκBζ promotes melanoma growth and immunotherapy resistanceIn: Nature Communications, Vol. 16, 2025, Nr. 1, 5387DOI (Open Access)
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Cutaneous melanoma : ESMO Clinical Practice Guideline for diagnosis, treatment and follow-upIn: Annals of Oncology, Vol. 36, 2025, Nr. 1, pp. 10 – 30
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Discordance, accuracy and reproducibility study of pathologists’ diagnosis of melanoma and melanocytic tumorsIn: Nature Communications, Vol. 16, 2025, Nr. 1, 789DOI (Open Access)
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Neoadjuvant intralesional targeted immunocytokines (daromun) in stage III melanomaIn: Annals of Oncology, Vol. 36, 2025, Nr. 10, pp. 1166 – 1177DOI (Open Access)
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Neoadjuvant or perioperative therapy for melanoma metastasis in clinical practice : An international surveyIn: The Lancet Oncology, Vol. 26, 2025, Nr. 1, pp. 12 – 14
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Retraction note: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistanceIn: Nature, Vol. 647, 2025, pp. 544DOI (Open Access)
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Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : Long-term, health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trialIn: The Lancet Oncology, Vol. 25, 2024, Nr. 9, pp. 1202 – 1212
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Author Correction : The evolutionary history of 2,658 cancersIn: Nature, Vol. 614, 2023, E42DOI (Open Access)
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Author Correction : Patterns of somatic structural variation in human cancer genomesIn: Nature, Vol. 614, 2023, Nr. 7948, pp. E38DOI (Open Access)
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Author Correction : Genomic basis for RNA alterations in cancerIn: Nature, Vol. 614, 2023, Nr. 7948, pp. E37DOI (Open Access)
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Author Correction: : The repertoire of mutational signatures in human cancerIn: Nature, Vol. 614, 2023, pp. E41DOI (Open Access)
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Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencingIn: Nature Genetics, Vol. 55, 2023, Nr. 6, 1076DOI (Open Access)
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Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancerIn: Nature Genetics, Vol. 55, 2023, Nr. 6, pp. 1079DOI (Open Access)
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Author Correction: Pan-cancer analysis of whole genomesIn: Nature, Vol. 614, 2023, Nr. 7948, pp. E39DOI (Open Access)
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Author Correction: The landscape of viral associations in human cancersIn: Nature Genetics, Vol. 55, 2023, Nr. 6, pp. 1077DOI (Open Access)
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Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencingIn: Nature Genetics, Vol. 52, 2023, pp. 331 – 341DOI (Open Access)
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Disruption of chromatin folding domains by somatic genomic rearrangements in human cancerIn: Nature Genetics, Vol. 52, 2023, Nr. 3, pp. 294 – 305DOI (Open Access)
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Neoadjuvant cemiplimab and surgery for stage II–IV cutaneous squamous-cell carcinoma : follow-up and survival outcomes of a single-arm, multicentre, phase 2 studyIn: The Lancet Oncology, Vol. 24, 2023, Nr. 11, pp. 1196 – 1205
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Neoadjuvant immunotherapy for melanoma is now ready for clinical practiceIn: Nature Medicine, Vol. 29, 2023, Nr. 6, pp. 1310 – 1312
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The German Network for Personalized Medicine to enhance patient care and translational researchIn: Nature Medicine, Vol. 29, 2023, Nr. 6, pp. 1298 – 1301
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The landscape of viral associations in human cancersIn: Nature Genetics, 2023, Nr. 52, pp. 320 – 330DOI (Open Access)
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The repertoire of mutational signatures in human cancerIn: Nature, Vol. 578, 2023, Nr. 7793, pp. 94 – 101DOI (Open Access)
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Author Correction : Divergent mutational processes distinguish hypoxic and normoxic tumoursIn: Nature Communications, Vol. 13, 2022, 7569DOI (Open Access)
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Author Correction : Combined burden and functional impact tests for cancer driver discovery using DriverPowerIn: Nature Communications, Vol. 13, 2022, 7571DOI (Open Access)
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Author Correction : A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patternsIn: Nature Communications, Vol. 13, 2022, 7573DOI (Open Access)
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Author Correction : Inferring structural variant cancer cell fractionIn: Nature Communications, Vol. 13, 2022, 7568DOI (Open Access)
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Author Correction : Integrative pathway enrichment analysis of multivariate omics dataIn: Nature Communications, Vol. 13, 2022, 7570DOI (Open Access)
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Author Correction : High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterationsIn: Nature Communications, Vol. 13, 2022, 7572DOI (Open Access)
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Author Correction : Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSigIn: Nature Communications, Vol. 13, 2022, 7567DOI (Open Access)
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Author Correction : Pathway and network analysis of more than 2500 whole cancer genomesIn: Nature Communications, Vol. 13, 2022, 7566DOI (Open Access)
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Author Correction : Genomic footprints of activated telomere maintenance mechanisms in cancerIn: Nature Communications, Vol. 13, 2022, 7574DOI (Open Access)
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Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716) : distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trialIn: The Lancet Oncology, Vol. 23, 2022, Nr. 11, pp. 1378 – 1388
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Persister state-directed transitioning and vulnerability in melanoma
32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,In: Nature Communications, Vol. 13, 2022, Nr. 1, pp. 35 – 36DOI, Online Full Text (Open Access) -
Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : distant metastasis-free survival results from a double-blind, randomised, controlled, phase 3 trialIn: The Lancet Oncology, Vol. 22, 2021, Nr. 5, pp. 643 – 654
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Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054) : health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trialIn: The Lancet Oncology, Vol. 22, 2021, Nr. 5, pp. 655 – 664DOI, Online Full Text (Open Access)
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Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib : A clinical validation studyIn: The Lancet Oncology, Vol. 22, 2021, Nr. 3, pp. 370 – 380DOI, Online Full Text (Open Access)
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EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumoursIn: Annals of Oncology, Vol. 32, 2021, Nr. 11, pp. 1332 – 1347DOI (Open Access)
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Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasionIn: Nature Genetics, Vol. 53, 2021, Nr. 3, pp. 332 – 341DOI (Open Access)
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A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patternsIn: Nature Communications, Vol. 11, 2020, 728DOI (Open Access)
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Adjuvant dabrafenib plus trametinib versus placebo in patients with resected, BRAFV⁶⁰⁰-mutant, stage III melanoma (COMBI-AD) : Exploratory biomarker analyses from a randomised, phase 3 trialIn: The Lancet Oncology, Vol. 21, 2020, Nr. 3, pp. 358 – 372DOI, Online Full Text (Open Access)
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Association between Immune-Related Adverse Events and Recurrence-Free Survival among Patients with Stage III Melanoma Randomized to Receive Pembrolizumab or Placebo : A Secondary Analysis of a Randomized Clinical TrialIn: JAMA Oncology, Vol. 6, 2020, Nr. 4, pp. 519 – 527DOI (Open Access)
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Association of BRAF V600E/K Mutation Status and Prior BRAF/MEK Inhibition with Pembrolizumab Outcomes in Advanced Melanoma : Pooled Analysis of 3 Clinical TrialsIn: JAMA Oncology, Vol. 6, 2020, Nr. 8, pp. 1256 – 1264
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Author Correction: Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanomaIn: Nature Medicine, Vol. 26, 2020, Nr. 7, pp. 1147DOI (Open Access)
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Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samplesIn: Nature Communications, Vol. 11, 2020, Nr. 1, pp. 6232DOI (Open Access)
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Author Correction: Tertiary lymphoid structures improve immunotherapy and survival in melanomaIn: Nature, Vol. 580, 2020, Nr. 7801, pp. E1DOI (Open Access)
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Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumoursIn: Nature Communications, Vol. 11, 2020, Nr. 1, pp. 1335DOI (Open Access)
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Cemiplimab in locally advanced cutaneous squamous cell carcinoma : results from an open-label, phase 2, single-arm trialIn: The Lancet Oncology, Vol. 21, 2020, Nr. 2, pp. 294 – 305DOI, Online Full Text (Open Access)
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Combined PD-1, BRAF and MEK inhibition in advanced BRAF-mutant melanoma : safety run-in and biomarker cohorts of COMBI-iIn: Nature Medicine, Vol. 26, 2020, Nr. 10, pp. 1557 – 1563
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Combined burden and functional impact tests for cancer driver discovery using DriverPowerIn: Nature Communications, Vol. 11, 2020, 734DOI (Open Access)
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Divergent mutational processes distinguish hypoxic and normoxic tumoursIn: Nature Communications, Vol. 11, 2020, 737DOI (Open Access)
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Elevated baseline serum PD-1 or PD-L1 predicts poor outcome of PD-1 inhibition therapy in metastatic melanomaIn: Annals of Oncology, Vol. 31, 2020, Nr. 1, pp. 144 – 152DOI (Open Access)
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Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibilityIn: Nature Genetics, Vol. 52, 2020, Nr. 5, pp. 494 – 504DOI, Online Full Text (Open Access)
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Genomic footprints of activated telomere maintenance mechanisms in cancerIn: Nature Communications, Vol. 11, 2020, 733DOI (Open Access)
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High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterationsIn: Nature Communications, Vol. 11, 2020, 736DOI (Open Access)
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Inferring structural variant cancer cell fractionIn: Nature Communications, Vol. 11, 2020, 730DOI (Open Access)
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Integrated molecular drivers coordinate biological and clinical states in melanomaIn: Nature Genetics, Vol. 52, 2020, Nr. 12, pp. 1373 – 1383DOI, Online Full Text (Open Access)
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Integrative pathway enrichment analysis of multivariate omics dataIn: Nature Communications, Vol. 11, 2020, 735DOI (Open Access)
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Metabolic heterogeneity confers differences in melanoma metastatic potentialIn: Nature, Vol. 577, 2020, Nr. 7788, pp. 115 – 120DOI, Online Full Text (Open Access)
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Pan-cancer analysis of whole genomesIn: Nature, Vol. 578, 2020, Nr. 7793, pp. 82 – 93DOI (Open Access)
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Pathway and network analysis of more than 2500 whole cancer genomesIn: Nature Communications, Vol. 11, 2020, 729DOI (Open Access)
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Prognostic impact of baseline tumour immune infiltrate on disease-free survival in patients with completely resected, BRAFv⁶⁰⁰ mutation–positive melanoma receiving adjuvant vemurafenibIn: Annals of Oncology, Vol. 31, 2020, Nr. 1, pp. 153 – 159DOI (Open Access)
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Rationale for Immune Checkpoint Inhibitors plus Targeted Therapy in Metastatic Melanoma : A ReviewIn: JAMA Oncology, Vol. 6, 2020, Nr. 12, pp. 1957 – 1966
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Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSigIn: Nature Communications, Vol. 11, 2020, 731DOI (Open Access)
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Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samplesIn: Nature Communications, Vol. 11, 2020, Nr. 1, pp. 4748DOI (Open Access)
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Sex differences in oncogenic mutational processesIn: Nature Communications, Vol. 11, 2020, Nr. 1, pp. 4330DOI (Open Access)
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Tertiary lymphoid structures improve immunotherapy and survival in melanomaIn: Nature, Vol. 577, 2020, Nr. 7791, pp. 561 – 565
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Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanomaIn: Nature Medicine, Vol. 25, 2019, Nr. 12, pp. 1916 – 1927DOI (Open Access)
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Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF melanoma (PACMEL) : a multicentre, open-label, randomised, controlled phase II trialIn: Annals of Oncology, Vol. 30, 2019, Nr. 2, pp. 317 – 324DOI (Open Access)
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Patient-reported outcomes in patients with resected, high-risk melanoma with BRAFV600E or BRAFV600K mutations treated with adjuvant dabrafenib plus trametinib (COMBI-AD) : a randomised, placebo-controlled, phase 3 trialIn: The Lancet Oncology, Vol. 20, 2019, Nr. 5, pp. 701 – 710
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Publisher Correction : Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathwaysIn: Nature Communications, Vol. 10, 2019, Nr. 1, pp. 299DOI (Open Access)
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Publisher Correction: Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathwaysIn: Nature Communications, Vol. 10, 2019, Nr. 1, pp. 299DOI (Open Access)
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Survival Outcomes in Patients with Previously Untreated BRAF Wild-Type Advanced Melanoma Treated with Nivolumab Therapy : Three-Year Follow-up of a Randomized Phase 3 TrialIn: JAMA Oncology, Vol. 5, 2019, Nr. 2, pp. 187 – 194
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Treatment in metastatic melanoma : Time to re-thinkIn: Annals of Oncology, Vol. 30, 2019, Nr. 4, pp. 501 – 503DOI (Open Access)
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A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint BlockadeIn: Cell, Vol. 175, 2018, Nr. 4, pp. 984 – 997.e24DOI (Open Access)
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Adjuvant melanoma therapy with new drugs : Should physicians continue to focus on metastatic disease or use it earlier in primary melanoma?In: The Lancet Oncology, Vol. 19, 2018, Nr. 12, pp. e720 – e725
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Adjuvant vemurafenib in resected, BRAF mutation-positive melanoma (BRIM8) : a randomised, double-blind, placebo-controlled, multicentre, phase 3 trialIn: The Lancet Oncology, Vol. 19, 2018, Nr. 4, pp. 510 – 520
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Adverse events (AEs) over time in patients (pts) treated with adjuvant dabrafenib plus trametinib (D + T) or placebo (Pbo) in the COMBI-AD trialIn: Annals of Oncology, Vol. 29, 2018, Nr. Suppl. 8, pp. viii446DOI (Open Access)
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Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy : a retrospective, multicohort analysisIn: The Lancet Oncology, Vol. 19, 2018, Nr. 3, pp. 310 – 322DOI, Online Full Text (Open Access)
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Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 BlockadeIn: Cell, Vol. 173, 2018, Nr. 3, pp. 624 – 633.e8DOI, Online Full Text (Open Access)
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Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS) : a multicentre, open-label, randomised phase 3 trialIn: The Lancet Oncology, Vol. 19, 2018, Nr. 5, pp. 603 – 615DOI (Open Access)
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Estimate of long-term relapse-free survival (RFS) and analysis of baseline factors associated with RFS in the COMBI-AD trialIn: Annals of Oncology, Vol. 29, 2018, Nr. Suppl. 8, pp. viii445DOI (Open Access)
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Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumorsIn: Nature Genetics, Vol. 50, 2018, Nr. 9, pp. 1271 – 1281DOI, Online Full Text (Open Access)
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Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067) : 4-year outcomes of a multicentre, randomised, phase 3 trialIn: The Lancet Oncology, Vol. 19, 2018, Nr. 11, pp. 1480 – 1492
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Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathwaysIn: Nature Communications, Vol. 9, 2018, Nr. 1, pp. 4774DOI (Open Access)
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Overall survival at 4 years of follow-up in a phase III trial of nivolumab plus ipilimumab combination therapy in advanced melanoma (CheckMate 067)In: Annals of Oncology, Vol. 29, 2018, Nr. Suppl. 8, pp. viii735DOI (Open Access)
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Overall survival in patients with BRAF-mutant melanoma receiving encorafenib plus binimetinib versus vemurafenib or encorafenib (COLUMBUS) : A multicentre, open-label, randomised, phase 3 trialIn: The Lancet Oncology, Vol. 19, 2018, Nr. 10, pp. 1315 – 1327
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Updated relapse-free survival (RFS) and biomarker analysis in the COMBI-AD trial of adjuvant dabrafenib + trametinib (D + T) in patients (pts) with resected BRAF V600-mutant stage III melanomaIn: Annals of Oncology, Vol. 29, 2018, Nr. Suppl. 8, pp. viii734 – viii735DOI (Open Access)
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Updated relapse-free survival (RFS) and biomarker analysis in the COMBI-AD trial of adjuvant dabrafenib plus trametinib (D plus T) in patients (pts) with resected BRAF V600-mutant stage III melanomaIn: Annals of Oncology, Vol. 29, 2018, Nr. Suppl. 8
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Acquired IFNγ 3 resistance impairs anti-Tumor immunity and gives rise to T-cell-resistant melanoma lesionsIn: Nature Communications, Vol. 8, 2017, 15440DOI (Open Access)
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Binimetinib versus dacarbazine in patients with advanced NRAS-mutant melanoma (NEMO) : a multicentre, open-label, randomised, phase 3 trialIn: The Lancet Oncology, Vol. 18, 2017, Nr. 4, pp. 435 – 445
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Dabrafenib plus trametinib versus dabrafenib monotherapy in patients with metastatic BRAF V600E/K-mutant melanoma : long-term survival and safety analysis of a phase 3 studyIn: Annals of Oncology, Vol. 28, 2017, Nr. 7, pp. 1631 – 1639DOI (Open Access)
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Efficacy and safety of nilotinib in patients with kit-mutated metastatic or inoperable melanoma : Final results from the global, single-arm, phase ii team trialIn: Annals of Oncology, Vol. 28, 2017, Nr. 6, pp. 1380 – 1387DOI (Open Access)
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Ipilimumab 10 mg/kg versus ipilimumab 3 mg/kg in patients with unresectable or metastatic melanoma : a randomised, double-blind, multicentre, phase 3 trialIn: The Lancet Oncology, Vol. 18, 2017, Nr. 5, pp. 611 – 622
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Nivolumab for Patients With Advanced Melanoma Treated Beyond Progression : Analysis of 2 Phase 3 Clinical TrialsIn: JAMA Oncology, Vol. 3, 2017, Nr. 11, pp. 1511 – 1519DOI, Online Full Text (Open Access)
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Predictors of responses to immune checkpoint blockade in advanced melanomaIn: Nature Communications, Vol. 8, 2017, pp. 592DOI (Open Access)
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Spatiotemporally restricted arenavirus replication induces immune surveillance and type i interferon-dependent tumour regressionIn: Nature Communications, Vol. 8, 2017, pp. 14447DOI (Open Access)
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Two intermittent vismodegib dosing regimens in patients with multiple basal-cell carcinomas (MIKIE) : a randomised, regimen-controlled, double-blind, phase 2 trialIn: The Lancet Oncology, Vol. 18, 2017, Nr. 3, pp. 404 – 412
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Vemurafenib in metastatic melanoma patients with brain metastases : An open-label, single-arm, phase 2, multicentre studyIn: Annals of Oncology, Vol. 28, 2017, Nr. 3, pp. 634 – 641
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A phase I, open-label study of pasireotide in patients with BRAF- and NRAS-wild type, unresectable and or metastatic melanomaIn: Annals of Oncology, Vol. 27, 2016, Nr. Suppl. 6
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Adjuvant treatment with pegylated interferon ?-2a versus low-dose interferon ?-2a in patients with high-risk melanoma : a randomized phase III DeCOG trialIn: Annals of Oncology, Vol. 27, 2016, Nr. 8, pp. 1625 – 1632DOI (Open Access)
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Analysis of BRAF V600E mutation status – concordance of results from circulating tumor DNA and tissue-based testing and impact on prediction of the clinical course in patients undergoing BRAFi therapyIn: Annals of Oncology, Vol. 27, 2016, Nr. Suppl. 6, pp. 1145P
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Analysis of patient-reported outcomes by disease progression status in patients (pts) with BRAF V600–mutant metastatic melanoma in the COMBI-d and COMBI-v trialsIn: Annals of Oncology, Vol. 27, 2016, Nr. Suppl. 6, pp. 1140P
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Checkpoint inhibitors : a new standard of care for advanced Merkel cell carcinoma?In: The Lancet Oncology, Vol. 17, 2016, Nr. 10, pp. 1337 – 1339
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Evaluation of the pharmacokinetic (PK) profile of vismodegib (VISMO) in patients (pts) with multiple basal cell carcinomas (BCCs) across two intermittent treatment regimens in the MIKIE studyIn: Annals of Oncology, Vol. 27, 2016, Nr. Suppl. 6, pp. 1152P
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Factors predictive of response, disease progression, and overall survival after dabrafenib and trametinib combination treatment : a pooled analysis of individual patient data from randomised trialsIn: The Lancet Oncology, Vol. 17, 2016, Nr. 12, pp. 1743 – 1754
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Final overall survival for KEYNOTE-002 : pembrolizumab (pembro) versus investigator-choice chemotherapy (chemo) for ipilimumab (ipi)-refractory melanomaIn: Annals of Oncology, Vol. 27, 2016, Nr. Suppl. 6, pp. 1107O
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Health-related quality-of-life (HRQOL) impact of dabrafenib (D) and trametinib (T) vs BRAF inhibitor (BRAFi) monotherapy by lactate dehydrogenase (LDH) in patients (pts) with BRAF V600–mutant melanomaIn: Annals of Oncology, Vol. 27, 2016, Nr. Suppl. 6, pp. 1137P
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PD-L1 expression as a biomarker for nivolumab (NIVO) plus ipilimumab (IPI) and NIVO alone in advanced melanoma (MEL) : A pooled analysisIn: Annals of Oncology, Vol. 27, 2016, Nr. Suppl. 6, pp. 1112PD
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Pooled analysis of factors to predict durable clinical outcomes with combination dabrafenib (D) and trametinib (T) across registration trialsIn: Annals of Oncology, Vol. 27, 2016, Nr. Suppl. 6, pp. 1134P
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Three-year estimate of overall survival in COMBI-v, a randomized phase 3 study evaluating first-line dabrafenib (D) + trametinib (T) in patients (pts) with unresectable or metastatic BRAF V600E/K–mutant cutaneous melanomaIn: Annals of Oncology, Vol. 27, 2016, Nr. Suppl. 6, pp. LBA40
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sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistanceIn: Nature, Vol. 532, 2016, Nr. 7598, pp. 250 – 254DOI, Online Full Text (Open Access)
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A multicenter DeCOG study on predictors of vemurafenib therapy outcome in melanoma : pretreatment impacts survivalIn: Annals of Oncology, Vol. 26, 2015, Nr. 3, pp. 573 – 582DOI (Open Access)
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Comparison of dabrafenib and trametinib combination therapy with vemurafenib monotherapy on health-related quality of life in patients with unresectable or metastatic cutaneous BRAF Val600-mutation-positive melanoma (COMBI-v) : results of a phase 3, open-label, randomised trialIn: The Lancet Oncology, Vol. 16, 2015, Nr. 13, pp. 1389 – 1398
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Disease kinetics for decision-making in advanced melanoma : a call for scenario-driven strategy trialsIn: The Lancet Oncology, Vol. 16, 2015, Nr. 13, pp. e522 – e526
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Expanded access programmes : patient interests versus clinical trial integrityIn: The Lancet Oncology, Vol. 16, 2015, Nr. 1, pp. 15 – 17
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Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanomaIn: Nature Genetics, Vol. 47, 2015, Nr. 9, pp. 987 – 995DOI, Online Full Text (Open Access)
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Genomic Classification of Cutaneous MelanomaIn: Cell, Vol. 161, 2015, Nr. 7, pp. 1681 – 1696DOI (Open Access)
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Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002) : a randomised, controlled, phase 2 trialIn: The Lancet Oncology, Vol. 16, 2015, Nr. 8, pp. 908 – 918
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Radiosensitization by BRAF inhibitor therapy-mechanism and frequency of toxicity in melanoma patientsIn: Annals of Oncology, Vol. 26, 2015, Nr. 6, pp. 1238 – 1244DOI (Open Access)
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Reply to the letters to the editor ‘Differential influence of vemurafenib and dabrafenib on patients' lymphocytes despite similar clinical efficacy in melanoma’ by Diwakar et al.In: Annals of Oncology, Vol. 26, 2015, Nr. 1, pp. 250 – 251
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Differential influence of vemurafenib and dabrafenib on patients' lymphocytes despite similar clinical efficacy in melanomaIn: Annals of Oncology, Vol. 25, 2014, Nr. 3, pp. 747 – 753
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Functional and symptom impact of trametinib versus chemotherapy in BRAF V600E advanced or metastatic melanoma : Quality-of-life analyses of the METRIC studyIn: Annals of Oncology, Vol. 25, 2014, Nr. 3, pp. 700 – 706
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Hepatic intra-arterial versus intravenous fotemustine in patients with liver metastases from uveal melanoma (EORTC 18021) : A multicentric randomized trialIn: Annals of Oncology, Vol. 25, 2014, Nr. 3, pp. 742 – 746
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Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3) : extended follow-up of a phase 3, randomised, open-label studyIn: The Lancet Oncology, Vol. 15, 2014, Nr. 3, pp. 323 – 332DOI, Online Full Text (Open Access)
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Surrogate endpoints for overall survival in metastatic melanoma: A meta-analysis of randomised controlled trialsIn: The Lancet Oncology, Vol. 15, 2014, Nr. 3, pp. 297 – 304
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Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanomaIn: Nature, Vol. 507, 2014, Nr. 7490, pp. 109 – 113
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MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: A non-randomised, open-label phase 2 studyIn: The Lancet Oncology, Vol. 14, 2013, Nr. 3, pp. 249 – 256
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Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma : A phase 2 double-blind randomised studyIn: The Lancet Oncology, Vol. 14, 2013, Nr. 8, pp. 733 – 740
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Advances and perspectives in immunotherapy of melanomaIn: Annals of Oncology, Vol. 23, 2012, Nr. Suppl. 10, pp. x104 – x108
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Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB) : A multicentre, open-label, phase 2 trialIn: The Lancet Oncology, Vol. 13, 2012, Nr. 11, pp. 1087 – 1095
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Melanoma genome sequencing reveals frequent PREX2 mutationsIn: Nature, Vol. 485, 2012, Nr. 7399, pp. 502 – 506
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Sorafenib and pegylated interferon-α2b in advanced metastatic melanoma : A multicenter phase II DeCOG trialIn: Annals of Oncology, Vol. 22, 2011, Nr. 7, pp. 1667 – 1674
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Ipilimumab monotherapy in patients with pretreated advanced melanoma : a randomised, double-blind, multicentre, phase 2, dose-ranging studyIn: The Lancet Oncology, Vol. 11, 2010, Nr. 2, pp. 155 – 164
