ZMB Member Tienush Rassaf

ZMB Member
Tienush Rassaf

Next ZMB-Member
Tienush Rassaf portrait
© UME

Prof. Dr. Tienush Rassaf

Director of:

Clinic for Cardiology and Vascular Medicine

University Hospital Essen
Hufelandstraße 55
45147 Essen

Research Overview

  • Myocardial ischemia-reperfusion syndrome
  • Ischemic pre- and postconditioning
  • Hypoxic vasodilation
  • NO-metabolism
  • Hypoxic nitrite signaling
  • Cardio-oncology

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Selected Publications

    Journal articles

  • Lena, Alessia; Wilkenshoff, Ursula; Hadzibegovic, Sara; Porthun, Jan; Rösnick, Lukas; Fröhlich, Ann-Kathrin; Zeller, Tanja; Karakas, Mahir; Keller, Ulrich; Ahn, Johann; Bullinger, Lars; Riess, Hanno; Rosen, Stuart D.; Lyon, Alexander R.; Lüscher, Thomas F.; Totzeck, Matthias; Rassaf, Tienush; Burkhoff, Daniel; Mehra, Mandeep R.; Bax, Jeroen J.; Butler, Javed; Edelmann, Frank; Haverkamp, Wilhelm; Anker, Stefan D.; Packer, Milton; Coats, Andrew J.S.; Haehling, Stephan von; Landmesser, Ulf; Anker, Markus S.
    Clinical and Prognostic Relevance of Cardiac Wasting in Patients With Advanced Cancer
    In: Journal of the American College of Cardiology (JACC) Vol. 81 (2023) Nr. 16, pp. 1569 - 1586
    ISSN: 1558-3597; 0735-1097
    Online Full Text: dx.doi.org/ (Open Access)
  • Wernhart, Simon; Goertz, Annika; Hedderich, Juergen; Papathanasiou, Maria; Hoffmann, Julia; Rassaf, Tienush; Lüdike, Peter
    Diastolic exercise stress testing in heart failure with preserved ejection fraction : The DEST-HF study
    In: European Journal of Heart Failure (2023)
    ISSN: 1878-1314; 1388-9842
    Online Full Text: dx.doi.org/ (Open Access)
  • Schrage, Benedikt; Sundermeyer, Jonas; Beer, Benedikt Norbert; Bertoldi, Letizia; Bernhardt, Alexander; Blankenberg, Stefan; Dauw, Jeroen; Dindane, Zouhir; Eckner, Dennis; Eitel, Ingo; Graf, Tobias; Horn, Patrick; Kirchhof, Paulus; Kluge, Stefan; Linke, Axel; Landmesser, Ulf; Lüdike, Peter; Lüsebrink, Enzo; Mangner, Norman; Maniuc, Octavian; Winkler, Sven Möbius; Nordbeck, Peter; Orban, Martin; Pappalardo, Federico; Pauschinger, Matthias; Pazdernik, Michal; Proudfoot, Alastair; Kelham, Matthew; Rassaf, Tienush; Reichenspurner, Hermann; Scherer, Clemens; Schulze, Paul Christian; Schwinger, Robert H.G.; Skurk, Carsten; Sramko, Marek; Tavazzi, Guido; Thiele, Holger; Villanova, Luca; Morici, Nuccia; Wechsler, Antonia; Westenfeld, Ralf; Winzer, Ephraim; Westermann, Dirk
    Use of mechanical circulatory support in patients with non-ischaemic cardiogenic shock
    In: European Journal of Heart Failure Vol. 25 (2023) Nr. 4, pp. 562 - 572
    ISSN: 1878-1314; 1388-9842
    Online Full Text: dx.doi.org/ (Open Access)
  • Totzeck, Matthias; Michel, Lars; Lin, Yi; Herrmann, Joerg; Rassaf, Tienush
    Cardiotoxicity from chimeric antigen receptor-T cell therapy for advanced malignancies
    In: European Heart Journal Vol. 43 (2022) Nr. 20, pp. 1928 - 1940
    ISSN: 0195-668X; 1522-9645
    Online Full Text: dx.doi.org/ (Open Access)
  • Salah, Husam M.; Goldberg, Lee R.; Molinger, Jeroen; Felker, G. Michael; Applefeld, Willard; Rassaf, Tienush; Tedford, Ryan J.; Mirro, Michael; Cleland, John G.F.; Fudim, Marat
    Diaphragmatic Function in Cardiovascular Disease : JACC Review Topic of the Week
    In: Journal of the American College of Cardiology (JACC) Vol. 80 (2022) Nr. 17, pp. 1647 - 1659
    ISSN: 1558-3597; 0735-1097
    Online Full Text: dx.doi.org/ (Open Access)
  • Mauri, Victor; Sugiura, Atsushi; Spieker, Max; Iliadis, Christos; Horn, Patrick; Öztürk, Can; Besler, Christian; Riebisch, Matthias; Al-Hammadi, Osamah; Ruf, Tobias; Gerçek, Muhammed; Grothusen, Christina; Mehr, Michael; Becher, Marc Ulrich; Mues, Christoph; Boeder, Niklas; Kreidel, Felix; Friedrichs, Kai; Westenfeld, Ralf; Braun, Daniel; Baldus, Stephan; Rassaf, Tienush; Thiele, Holger; Nickenig, Georg; Hausleiter, Jörg; Möllmann, Helge; Kelm, Malte; Rudolph, Volker; Stephan von Bardeleben, Ralph; Nef, Holger M.; Lüdike, Peter; Lurz, Philipp; Pfister, Roman
    Early Outcomes of 2 Mitral Valve Transcatheter Leaflet Approximation Devices : A Propensity Score–Matched Multicenter Comparison
    In: JACC Cardiovascular Interventions Vol. 15 (2022) Nr. 24, pp. 2541 - 2551
    ISSN: 1876-7605; 1936-8798
    Online Full Text: dx.doi.org/
  • Wild, Mirjam G.; Löw, Kornelia; Rosch, Sebastian; Gerçek, Muhammed; Higuchi, Satoshi; Massberg, Steffen; Näbauer, Michael; Rudolph, Volker; Markovic, Sinisa; Boekstegers, Peter; Rassaf, Tienush; Lüdike, Peter; Geisler, Tobias; Braun, Daniel; Stolz, Lukas; Praz, Fabien; Lurz, Philip; Hausleiter, Jörg
    Multicenter Experience With the Transcatheter Leaflet Repair System for Symptomatic Tricuspid Regurgitation
    In: JACC Cardiovascular Interventions Vol. 15 (2022) Nr. 13, pp. 1352 - 1363
    ISSN: 1876-7605; 1936-8798
    Online Full Text: dx.doi.org/ (Open Access)
  • Michel, Lars; Helfrich, Iris; Hendgen-Cotta, Ulrike Barbara; Mincu, Raluca-Ileana; Korste, Sebastian; Mrotzek, Simone Maria; Spomer, Armin; Odersky, Andrea; Rischpler, Christoph; Herrmann, Ken; Umutlu, Lale; Coman, Cristina; Ahrends, Robert; Sickmann, Albert; Löffek, Stefanie; Livingstone, Elisabeth; Ugurel, Selma; Zimmer, Lisa; Gunzer, Matthias; Schadendorf, Dirk; Totzeck, Matthias; Rassaf, Tienush
    Targeting early stages of cardiotoxicity from anti-PD1 immune checkpoint inhibitor therapy
    In: European Heart Journal Vol. 43 (2022) Nr. 4, pp. 316 - 329
    ISSN: 0195-668X; 1522-9645
    Online Full Text: dx.doi.org/
  • Lüdike, Peter; Heusch, Gerd; Rassaf, Tienush
    The RUHR Heart Failure Network : Improved heart failure care in a metropolitan area
    In: European Heart Journal Vol. 43 (2022) Nr. 45, pp. 4675 - 4676
    ISSN: 0195-668X; 1522-9645
    Online Full Text: dx.doi.org/ (Open Access)
  • Mrotzek, Simone M.; Lena, Alessia; Hadzibegovic, Sara; Ludwig, Ria; Al-Rashid, Fadi; Mahabadi, Amir Abbas; Mincu, Raluca I.; Michel, Lars; Johannsen, Laura; Hinrichs, Lena; Schuler, Martin; Keller, Ulrich; Anker, Stefan D.; Landmesser, Ulf; Rassaf, Tienush; Anker, Markus S.; Totzeck, Matthias
    Assessment of coronary artery disease during hospitalization for cancer treatment
    In: Clinical Research in Cardiology Vol. 110 (2021) Nr. 2, pp. 200 - 210
    ISSN: 1861-0692; 1861-0684
    Online Full Text: dx.doi.org/ (Open Access)
  • Lehmann, Lorenz H.; Cautela, Jennifer; Palaskas, Nicolas; Baik, Alan H.; Meijers, Wouter C.; Allenbach, Yves; Alexandre, Joachim; Rassaf, Tienush; Müller, Oliver J.; Aras, Mandar; Asnani, Aarti H.; Deswal, Anita; Laufer-Perl, Michal; Thuny, Franck; Kerneis, Mathieu; Hayek, Salim S.; Ederhy, Stéphane; Salem, Joe-Elie; Moslehi, Javid J.
    Clinical Strategy for the Diagnosis and Treatment of Immune Checkpoint Inhibitor-Associated Myocarditis : A Narrative Review
    In: JAMA Cardiology (2021)
    ISSN: 2380-6591; 2380-6583
    Online Full Text: dx.doi.org/
  • Lüdike, Peter; Riebisch, Matthias; Weymann, Alexander; Ruhparwar, Arjang; Rassaf, Tienush; Mahabadi, Amir Abbas
    Feasibility of a Novel Transcatheter Valve Repair System to Treat Tricuspid Regurgitation in ccTGA
    In: JACC: Case Reports Vol. 3 (2021) Nr. 6, pp. 893 - 896
    ISSN: 2666-0849
    Online Full Text: dx.doi.org/ (Open Access)
  • Lüdike, Peter; Riebisch, Matthias; Schindhelm, Florian; Papathanasiou, Maria; Lind, Alexander Y.; Weymann, Alexander; Schmack, Bastian; Ruhparwar, Arjang; Rassaf, Tienush; Mahabadi, Amir Abbas
    Impact of Mitral Valve Repair Technologies on Predictability of Post-Delivery Residual Mitral Regurgitation
    In: JACC Cardiovascular Interventions Vol. 14 (2021) Nr. 23, pp. 2638 - 2640
    ISSN: 1876-7605; 1936-8798
    Online Full Text: dx.doi.org/ (Open Access)
  • Leppert, Florian; Siebermair, Johannes; Wesemann, Ulrich; Martens, Eimo; Sattler, Stefan M.; Scholz, Stefan; Veith, Stefan; Greiner, Wolfgang; Rassaf, Tienush; Kääb, Stefan; Wakili, Reza
    The INFluence of Remote monitoring on Anxiety/depRession, quality of lifE, and Device acceptance in ICD patients : A prospective, randomized, controlled, single-center trial
    In: Clinical Research in Cardiology Vol. 110 (2021) Nr. 6, pp. 789 - 800
    ISSN: 1861-0692; 1861-0684
    Online Full Text: dx.doi.org/ (Open Access)
  • Rassaf, Tienush; Heusch, Gerd
    The West German heart and vascular center at university medicine Essen
    In: European Heart Journal Vol. 42 (2021) Nr. 10, pp. 963 - 964
    ISSN: 0195-668X; 1522-9645
    Online Full Text: dx.doi.org/ (Open Access)
  • Dykun, Iryna; Mahabadi, Amir Abbas; Rassaf, Tienush
    A clinical perspective on the 2019 ESC/EAS guidelines for the management of dyslipidaemias: PCSK-9 inhibitors for all?
    In: European Heart Journal Vol. 41 (2020) Nr. 24, pp. 2331
    ISSN: 1522-9645
    Online Full Text: dx.doi.org/
  • Balcer, B; Dykun, Iryna; Hendricks, Stefanie; Al-Rashid, Fadi; Totzeck, Matthias; Rassaf, Tienush; Mahabadi, Amir Abbas;
    Anemia increases long-term mortality in patients undergoing conventional coronary angiography – the ECAT registry
    ESC Congress 2020 – The Digital Experience 29 August – 1 September 2020,
    In: European Heart Journal Vol. 41 (2020) Nr. Supplement_2, pp. 1508
    ISSN: 0195-668X; 1522-9645
    Online Full Text: dx.doi.org/
  • Settelmeier, Stephan; Rassaf, Tienush; Giannitsis, Evangelos; Münzel, Thomas; Breuckmann, Frank
    Capacity changes in German certified chest pain units during COVID-19 outbreak response
    In: Clinical Research in Cardiology Vol. 109 (2020) Nr. 12, pp. 1469 - 1475
    ISSN: 1861-0692; 1861-0684
    Online Full Text: dx.doi.org/ (Open Access)
  • Totzeck, Matthias; Siebermair, Johannes; Rassaf, Tienush; Rischpler, Christoph
    Cardiac fibroblast activation detected by positron emission tomography/computed tomography as a possible sign of cardiotoxicity
    In: European Heart Journal Vol. 41 (2020) Nr. 9, pp. 1060
    ISSN: 1522-9645; 0195-668X
    Online Full Text: dx.doi.org/
  • Michel, Lars; Rassaf, Tienush; Totzeck, Matthias
    Evaluating biomarkers as predictors of cancer therapy cardiotoxicity : All you need is a meta-analysis? Reply
    In: European Journal of Heart Failure Vol. 22 (2020) Nr. 7, pp. 1285 - 1286
    ISSN: 1878-1314; 1388-9842
    Online Full Text: dx.doi.org/ (Open Access)
  • Mauri, Victor; Besler, Christian; Riebisch, Matthias; Al-Hammadi, Osamah; Ruf, Tobias; Gerçek, Muhammed; Horn, Patrick; Grothusen, Christina; Mehr, Michael; Becher, Marc Ulrich; Mues, Christoph; Boeder, Niklas; Kreidel, Felix; Friedrichs, Kai; Westenfeld, Ralf; Braun, Daniel; Öztürk, Can; Baldus, Stephan; Rassaf, Tienush; Thiele, Holger; Nickenig, Georg; Hausleiter, Jörg; Möllmann, Helge; Kelm, Malte; Rudolph, Volker; von Bardeleben, Ralph-Stephan; Nef, Holger M.; Lüdike, Peter; Lurz, Philipp; Pfister, Roman
    German Multicenter Experience With a New Leaflet-Based Transcatheter Mitral Valve Repair System for Mitral Regurgitation
    In: JACC Cardiovascular Interventions Vol. 13 (2020) Nr. 23, pp. 2769 - 2778
    ISSN: 1876-7605; 1936-8798
    Online Full Text: dx.doi.org/ (Open Access)
  • Lind, Alexander; Totzeck, Matthias; Mahabadi, Amir Abbas; Janosi, Rolf Alexander; El Gabry, Mohamed; Ruhparwar, Arjang; Mrotzek, Simone; Hinrichs, Lena; Akdeniz, Merve; Rassaf, Tienush; Mincu, Raluca I.
    Impact of Cancer in Patients Undergoing Transcatheter Aortic Valve Replacement: A Single-Center Study
    In: JACC: CardioOncology Vol. 2 (2020) Nr. 5, pp. 735 - 743
    ISSN: 2666-0873
    Online Full Text: dx.doi.org/ (Open Access)
  • Rassaf, Tienush; Totzeck, Matthias; Backs, Johannes; Bokemeyer, Carsten; Hallek, Michael; Hilfiker-Kleiner, Denise; Hochhaus, Andreas; Lüftner, Diana; Müller, Oliver J.; Neudorf, Ulrich; Pfister, Roman; von Haehling, Stephan; Lehmann, Lorenz H.; Bauersachs, Johann
    Onco-Cardiology : Consensus Paper of the German Cardiac Society, the German Society for Pediatric Cardiology and Congenital Heart Defects and the German Society for Hematology and Medical Oncology
    In: Clinical Research in Cardiology (2020)
    ISSN: 1861-0692; 1861-0684
    Online Full Text: dx.doi.org/ (Open Access)
  • Mahabadi, Amir Abbas; Rassaf, Tienush
    Radiomic Assessment of Pericoronary Adipose Tissue : Detecting the Vulnerable Patient
    In: Journal of the American College of Cardiology: Cardiovascular Imaging Vol. 13 (2020) Nr. 11, pp. 2384 - 2385
    ISSN: 1876-7591; 1936-878X
    Online Full Text: dx.doi.org/ (Open Access)
  • Michel, Lars; Mincu, Raluca I.; Mahabadi, Amir Abbas; Settelmeier, Stephan; Al-Rashid, Fadi; Rassaf, Tienush; Totzeck, Matthias
    Troponins and brain natriuretic peptides for the prediction of cardiotoxicity in cancer patients : a meta-analysis
    In: European Journal of Heart Failure Vol. 22 (2020) Nr. 2, pp. 350 - 361
    ISSN: 1878-1314; 1388-9842
    Online Full Text: dx.doi.org/ (Open Access)
  • Mincu, Raluca I.; Mahabadi, Amir Abbas; Michel, Lars; Mrotzek, Simone; Schadendorf, Dirk; Rassaf, Tienush; Totzeck, Matthias
    Cardiovascular Adverse Events Associated with BRAF and MEK Inhibitors : A Systematic Review and Meta-analysis
    In: JAMA Network Open Vol. 2 (2019) Nr. 8, pp. e198890
    ISSN: 2574-3805
    Online Full Text: dx.doi.org/ (Open Access)
  • Merz, Simon F.; Korste, Sebastian; Bornemann, Lea; Michel, Lars; Stock, Pia; Squire, Anthony; Soun, Camille; Engel, Daniel Robert; Detzer, Julia; Lörchner, Holger; Hermann, Dirk M.; Kamler, Markus; Klode, Joachim; Hendgen-Cotta, Ulrike B.; Rassaf, Tienush; Gunzer, Matthias; Totzeck, Matthias
    Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response
    In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2312
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Merz, Simon F.; Korste, Sebastian; Bornemann, Lea; Michel, Lars; Stock, Pia; Squire, Anthony; Soun, Camille; Engel, Daniel Robert; Detzer, Julia; Lörchner, Holger; Hermann, Dirk M.; Kamler, Markus; Klode, Joachim; Hendgen-Cotta, Ulrike B.; Rassaf, Tienush; Gunzer, Matthias; Totzeck, Matthias
    Publisher Correction: Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response
    In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 2768
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Totzeck, Matthias; Mahabadi, Amir Abbas; Schlosser, Thomas Wilfried; Rassaf, Tienush
    Weightlifting unmasks high-risk coronary anomaly
    In: European Heart Journal Vol. 40 (2019) Nr. 1, pp. 72
    ISSN: 0195-668X; 1522-9645
    Online Full Text: dx.doi.org/ (Open Access)
  • Mahabadi, Amir Abbas; Rassaf, Tienush
    Imaging of coronary inflammation for cardiovascular risk prediction
    In: The Lancet Vol. 392 (2018) Nr. 10151, pp. 894 - 896
    ISSN: 1474-547X; 0140-6736
    Online Full Text: dx.doi.org/ (Open Access)
  • Lortz, Julia; Tsagakis, Konstantinos; Rammos, Christos; Rogmann, Kim; Horacek, Michael; Schlosser, Thomas Wilfried; Jakob, Heinz G.; Rassaf, Tienush; Janosi, RolfAlexan
    Intravascular ultrasound for stent graft sizing in emergency thoracic endovascular aortic repair
    In: Journal of the American College of Cardiology Vol. 70 (2017) Nr. 18, pp. B297
    ISSN: 0735-1097; 1558-3597
  • Rammos, Christos; Hendgen-Cotta, Ulrike B.; Totzeck, Matthias; Pohl, Julia; Lüdike, Peter; Flögel, Ulrich; Deenen, René; Köhrer, Karl; French, Brent A.; Gödecke, Axel; Kelm, Malte; Rassaf, Tienush
    Impact of dietary nitrate on age-related diastolic dysfunction
    In: European Journal of Heart Failure Vol. 18 (2016) Nr. 6, pp. 599 - 610
    ISSN: 1878-1314; 1388-9842
    Online Full Text: dx.doi.org/ (Open Access)
  • Westhofen, G.; Ganster, C.; Beier, F.; Rassaf, Tienush; Al-Ali, H. K.; Stuhlmann, R.; Glass, B.; Bacher, U.; Brummendorf, T. H.; Germing, U.; Gattermann, N.; Haase, D.
    Iron Overload- accosiated genetic instability in Myelodysplastic Syndrome
    In: Haematologica Vol. 101 (2016) Nr. Suppl. 1, pp. 496 - 496
    ISSN: 0390-6078; 1592-8721
    (Open Access)
  • Heusch, Gerd; Rassaf, Tienush
    Time to Give Up on Cardioprotection? : A Critical Appraisal of Clinical Studies on Ischemic Pre-, Post-, and Remote Conditioning
    In: Circulation Research Vol. 119 (2016) Nr. 5, pp. 676 - 695
    ISSN: 1524-4571; 0009-7330
    Online Full Text: dx.doi.org/
  • Rassaf, Tienush; Totzeck, Matthias; Hendgen-Cotta, Ulrike B.; Shiva, Sruti; Heusch, Gerd; Kelm, Malte
    Circulating nitrite contributes to cardioprotection by remote ischemic preconditioning
    In: Circulation Research Vol. 114 (2014) Nr. 10, pp. 1601 - 1610
    ISSN: 1524-4571; 0009-7330
    Online Full Text: dx.doi.org/
  • Kehmeier, Eva S.; Lepper, Wolfgang; Kropp, Martina; Heiss, Christian; Hendgen-Cotta, Ulrike B.; Balzer, Jan; Neizel, Mirja; Meyer, Christian; Merx, Marc W.; Verde, Pablo E.; Ohmann, Christian; Heusch, Gerd; Kelm, Malte; Rassaf, Tienush
    TNF-α, myocardial perfusion and function in patients with ST-segment elevation myocardial infarction and primary percutaneous coronary intervention
    In: Clinical Research in Cardiology Vol. 101 (2012) Nr. 10, pp. 815 - 827
    ISSN: 1861-0692; 1861-0684
    Online Full Text: dx.doi.org/