ZMB Member Diana Klein

ZMB Member
Diana Klein

Next ZMB-Member
Diana Klein portrait
© UKE/Klein

Prof. Dr. Diana Klein

Institute of Cell Biology (Tumor Research)
University Hospital Essen
Virchowstr. 173
45122 Essen

Research Overview

Ionizing radiation leads to DNA damage, which primarily causes rapidly proliferating tumor cells to be damaged and killed. In addition, it has been shown in recent years that the tumor microenvironment, and particularly the stromal endothelial cells and fibroblasts play a crucial role in the radiation response and that the tumor stroma could thus be a promising therapeutic target. Thus, understanding the nature of the tumor environment today may be equally important for future cancer therapies as understanding cancer genetics per se. The research work of this junior research group focuses on the importance of endothelial cells (as well as fibroblasts) and therapy-induced vascular remodeling as well as tissue remodelling for radiosensitivity. Herein, crucial signaling molecules/pathways are aimed to be identified that could serve as therapeutically targets (i) to radiosensitize tumor tissue (and thus improve the efficiency of radiation therapy) or (ii) to protect the normal tissue during radiation (to reduce the risk of radiation-induced normal tissue damage).
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Publications

    Journal articles

  • Steens, Jennifer; Klar, Lea; Hansel, Christine; Slama, Alexis; Hager, Thomas; Jendrossek, Verena; Aigner, Clemens; Klein, Diana
    The vascular nature of lung-resident mesenchymal stem cells
    In: Stem Cells Translational Medicine Vol. 10 (2021) Nr. 1, pp. 128 - 143
    ISSN: 2157-6580; 2157-6564
  • Ketteler, Julia; Wittka, Alina; Leonetti, Daniela; Roy, Victoria Veas; Estephan, Hala; Maier, Patrick; Reis, Henning; Herskind, Carsten; Jendrossek, Verena; Paris, Francois; Klein, Diana
    Caveolin-1 regulates the ASMase/ceramide-mediated radiation response of endothelial cells in the context of tumor–stroma interactions
    In: Cell Death and Disease Vol. 11 (2020) Nr. 4,
    ISSN: 2041-4889
  • Hansel, Christine; Jendrossek, Verena; Klein, Diana
    Cellular Senescence in the Lung : The Central Role of Senescent Epithelial Cells
    In: International Journal of Molecular Sciences Vol. 21 (2020) Nr. 9, pp. 3279
    ISSN: 1422-0067; 1661-6596
  • Steens, Jennifer; Unger, Kristian; Klar, Lea; Neureiter, Anika; Wieber, Karolin; Hess, Julia; Jakob, Heinz G.; Klump, Hannes; Klein, Diana
    Direct conversion of human fibroblasts into therapeutically active vascular wall-typical mesenchymal stem cells
    In: Cellular and Molecular Life Sciences: CMLS Vol. 77 (2020) Nr. 17, pp. 3401 - 3422
    ISSN: 1420-682X; 1420-9071
  • Meyer, Alina V.; Klein, Diana; de Leve, Simone; Szymonowicz, Klaudia; Stuschke, Martin; Robson, Simon C.; Jendrossek, Verena; Wirsdörfer, Florian
    Host CD39 Deficiency Affects Radiation-Induced Tumor Growth Delay and Aggravates Radiation-Induced Normal Tissue Toxicity
    In: Frontiers in Oncology Vol. 10 (2020) pp. 554883
    ISSN: 2234-943X
  • Klein, Diana
    Lung Multipotent Stem Cells of Mesenchymal Nature : Cellular Basis, Clinical Relevance, and Implications for Stem Cell Therapy
    In: Antioxidants and Redox Signaling (2020) in press
    ISSN: 1523-0864; 1557-7716
  • Steer, Alizée; Cordes, Nils; Jendrossek, Verena; Klein, Diana
    Impact of Cancer-Associated Fibroblast on the Radiation-Response of Solid Xenograft Tumors
    In: Frontiers in Molecular Biosciences Vol. 6 (2019) pp. 70
    ISSN: 2296-889X
  • Wiesemann, Alina; Ketteler, Julia; Slama, Alexis; Wirsdörfer, Florian; Hager, Thomas; Röck, Katharina; Engel, Daniel Robert; Fischer, Jens W.; Aigner, Clemens; Jendrossek, Verena; Klein, Diana
    Inhibition of Radiation-Induced Ccl2 Signaling Protects Lungs from Vascular Dysfunction and Endothelial Cell Loss
    In: Antioxidants and Redox Signaling Vol. 30 (2019) Nr. 2, pp. 213 - 231
    ISSN: 1523-0864; 1557-7716
  • Ketteler, Julia; Panic, Andrej; Reis, Henning; Wittka, Alina; Maier, Patrick; Herskind, Carsten; Yagüe, Ernesto; Jendrossek, Verena; Klein, Diana
    Progression-Related Loss of Stromal Caveolin 1 Levels Mediates Radiation Resistance in Prostate Carcinoma via the Apoptosis Inhibitor TRIAP1
    In: Journal of Clinical Medicine Vol. 8 (2019) Nr. 3, pp. 348
    ISSN: 2077-0383
  • Shannan, B.; Matschke, Johann; Chauvistré, Heike; Vogel, F.; Klein, Diana; Meier, Friedegund; Westphal, Dana; Bruns, Johannes; Rauschenberg, Ricarda; Utikal, Jochen; Forschner, Andrea; Berking, Carola; Terheyden, Patrick; Dabrowski, Evelyn; Gutzmer, Ralf; Rafei-Shamsabadi, David Ali; Meiss, Frank; Heinzerling, Lucie M.; Zimmer, Lisa; Livingstone, Elisabeth; Váraljai, Renáta; Hoewner, A.; Horn, Susanne; Klode, Joachim; Stuschke, Martin; Scheffler, Björn; Marchetto, Aruna; Sannino, Giuseppina; Grünewald, Thomas Georg Philipp; Schadendorf, Dirk; Jendrossek, Verena; Rösch, Alexander
    Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV⁶⁰⁰E inhibition in melanoma
    In: European Journal of Cancer Vol. 109 (2019) pp. 137 - 153
    ISSN: 1879-0852; 0959-8049
  • Zernickel, Erika; Sak, Ali; Riaz, Assad; Klein, Diana; Groneberg, Michael; Stuschke, Martin
    Targeting of BRM Sensitizes BRG1-Mutant Lung Cancer Cell Lines to Radiotherapy
    In: Molecular Cancer Therapeutics Vol. 18 (2019) Nr. 3, pp. 656 - 666
    ISSN: 1538-8514; 1535-7163
  • Ketteler, Julia; Klein, Diana
    Caveolin-1, cancer and therapy resistance
    In: International Journal of Cancer Vol. 143 (2018) Nr. 9, pp. 2092 - 2104
    ISSN: 0020-7136; 1097-0215
  • Stanurova, Jana; Neureiter, Anika; Hiber, Michaela; de Oliveira Kessler, Hannah; Stolp, Kristin; Goetzke, Roman; Klein, Diana; Bankfalvi, Agnes; Klump, Hannes; Steenpass, Laura
    Corrigendum : Angelman syndrome-derived neurons display late onset of paternal UBE3A silencing
    In: Scientific Reports Vol. 8 (2018) pp. 46952
    ISSN: 2045-2322
  • Steens, Jennifer; Klein, Diana
    Current Strategies to Generate Human Mesenchymal Stem Cells In Vitro
    In: Stem Cells International Vol. 2018 (2018) pp. 6726185
    ISSN: 1687-9678; 1687-966X
  • Hlouschek, Julian; Ritter, Violetta; Wirsdörfer, Florian; Klein, Diana; Jendrossek, Verena; Matschke, Johann
    Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxia
    In: Cancer Letters Vol. 439 (2018) pp. 24 - 38
    ISSN: 0304-3835
  • Klein, Diana
    The tumor vascular endothelium as decision maker in cancer therapy
    In: Frontiers in Oncology Vol. 8 (2018) pp. 00367
    ISSN: 2234-943X
  • Klein, Diana
    iPSCs-based generation of vascular cells : reprogramming approaches and applications
    In: Cellular and Molecular Life Sciences - CMLS Vol. 75 (2018) Nr. 8, pp. 1411 - 1433
    ISSN: 1420-682X; 1420-9071; 0014-4754
  • Oeck, S.; Al-Refae, K.; Riffkin, H.; Wiel, G.; Handrick, R.; Klein, Diana; Iliakis, George; Jendrossek, Verena
    Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity
    In: Scientific Reports Vol. 7 (2017) pp. 42700
    ISSN: 2045-2322
  • Hess, Julia; Unger, Kristian; Orth, Michael; Schötz, Ulrike; Schüttrumpf, Lars; Zangen, Verena; Gimenez-Aznar, Igor; Michna, Agata; Schneider, Ludmila; Stamp, Ramona; Selmansberger, Martin; Braselmann, Herbert; Hieber, Ludwig; Drexler, Guido A.; Kuger, Sebastian; Klein, Diana; Jendrossek, Verena; Friedl, Anna A.; Belka, Claus; Zitzelsberger, Horst; Lauber, Kirsten
    Genomic amplification of Fanconi anemia complementation group A (FancA) in head and neck squamous cell carcinoma (HNSCC) : Cellular mechanisms of radioresistance and clinical relevance
    In: Cancer letters: an international journal providing a forum for original and pertinent contributions in cancer research Vol. 386 (2017) pp. 87 - 99
    ISSN: 0304-3835; 1872-7980
  • Steens, Jennifer; Zuk, Melanie; Benchellal, Mohamed; Bornemann, Lea; Teichweyde, Nadine; Hess, Julia; Unger, Kristian; Görgens, André; Klump, Hannes; Klein, Diana
    In Vitro Generation of Vascular Wall-Resident Multipotent Stem Cells of Mesenchymal Nature from Murine Induced Pluripotent Stem Cells
    In: Stem Cell Reports Vol. 8 (2017) Nr. 4, pp. 919 - 932
    ISSN: 2213-6711
  • Klein, Diana; Steens, Jennifer; Wiesemann, Alina; Schulz, Florian; Kaschani, Farnusch; Röck, Katharina; Yamaguchi, Masahiro; Wirsdörfer, Florian; Kaiser, Markus; Fischer, Jens W.; Stuschke, Martin; Jendrossek, Verena
    Mesenchymal stem cell therapy protects lungs from radiation-induced endothelial cell loss by restoring superoxide dismutase 1 expression
    In: Antioxidants and Redox Signaling Vol. 26 (2017) Nr. 11, pp. 563 - 582
    ISSN: 1523-0864; 1557-7716
  • Panic, Andrej; Ketteler, Julia; Reis, Henning; Sak, Ali; Herskind, Carsten; Maier, Patrick; Rübben, Herbert; Jendrossek, Verena; Klein, Diana
    Progression-related loss of stromal Caveolin 1 levels fosters the growth of human PC3 xenografts and mediates radiation resistance
    In: Scientific Reports Vol. 7 (2017) pp. 41138
    ISSN: 2045-2322
  • Stanurova, Jana; Neureiter, Anika; Hiber, Michaela; de Oliveira Kessler, Hannah; Stolp, Kristin; Goetzke, Roman; Klein, Diana; Bankfalvi, Agnes; Klump, Hannes; Steenpass, Laura
    Angelman syndrome-derived neurons display late onset of paternal UBE3A silencing
    In: Scientific Reports Vol. 6 (2016) pp. 30792
    ISSN: 2045-2322
  • Kipkeew, Friederike; Kirsch, Manuela; Klein, Diana; Wülling, Manuela; Winterhager, Elke; Gellhaus, Alexandra
    CCN1 (CYR61) and CCN3 (NOV) signaling drives human trophoblast cells into senescence and stimulates migration properties
    In: Cell Adhesion & Migration Vol. 10 (2016) Nr. 1-2, pp. 163 - 178
    ISSN: 1933-6918
  • Kirsch, Michael; Kipkeew, Friederike; Klein, Diana; Wülling, Manuela; Winterhager, Elke; Gellhaus, Alexandra
    CCN3 signaling is dysregulated in the pregnancy disorder preeclampsia
    In: Journal of Reproductive Immunology Vol. 115 (2016) pp. 71 - 71
    ISSN: 0165-0378
  • Wirsdörfer, Florian; de Leve, Simone; Cappuccini, Federica; Eldh, Therese; Meyer, Alina V; Gau, Eva; Thompson, Linda F; Chen, Ning-Yuan; Karmouty-Quintana, Harry; Fischer, Ute; Kasper, Michael; Klein, Diana; Ritchey, Jerry W; Blackburn, Michael R; Westendorf, Astrid; Stuschke, Martin; Jendrossek, Verena
    Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis
    In: Cancer Research Vol. 76 (2016) Nr. 10, pp. 3045 - 3056
    ISSN: 0008-5472; 1538-7445
  • Schütze, Alexandra; Vogeley, Christian; Gorges, Tobias; Twarock, Sören; Butschan, Jonas; Babayan, Anna; Klein, Diana; Knauer, Shirley; Metzen, Eric; Müller, Volkmar; Jendrossek, Verena; Pantel, Klaus; Milde-Langosch, Karin; Fischer, Jens W.; Röck, Katharina
    RHAMM splice variants confer radiosensitivity in human breast cancer cell lines
    In: OncoTarget Vol. 7 (2016) Nr. 16, pp. 21428 - 21440
    ISSN: 1949-2553
  • Matschke, Johann; Riffkin, Helena; Klein, Diana; Handrick, René; Lüdemann, Lutz; Metzen, Eric; Shlomi, Tomer; Stuschke, Martin; Jendrossek, Verena
    Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling Hypoxia
    In: Antioxidants and Redox Signaling Vol. 25 (2016) Nr. 2, pp. 89 - 107
    ISSN: 1523-0864; 1557-7716
  • Klein, Diana; Schmetter, Alexandra; Imsak, Roze; Wirsdörfer, Florian; Unger, Kristian; Jastrow, Holger; Stuschke, Martin; Jendrossek, Verena
    Therapy with multipotent mesenchymal stromal cells protects lungs from radiation-induced injury and reduces the risk of lung metastasis
    In: Antioxidants and Redox Signaling Vol. 24 (2016) Nr. 2, pp. 53 - 69
    ISSN: 1557-7716; 1523-0864
  • Klein, Diana
    Vascular Wall-Resident Multipotent Stem Cells of Mesenchymal Nature within the Process of Vascular Remodeling: Cellular Basis, Clinical Relevance, and Implications for Stem Cell Therapy
    In: Stem Cells International Vol. 2016 (2016) pp. 1905846
    ISSN: 1687-9678
  • Klein, Diana; Schmitz, T.; Verhelst, V.; Panic, Andrej; Schenck, Marcus; Reis, Henning; Drab, Marek; Sak, Ali; Herskind, Carsten; Maier, Patrick J.; Jendrossek, Verena
    Endothelial Caveolin-1 regulates the radiation response of epithelial prostate tumors
    In: Oncogenesis Vol. 4 (2015) pp. e148
    ISSN: 2157-9024
  • Gimenez-Aznar, I.; Michna, A.; Ludwig, H.; Braselmann, H.; Klein, Diana; Ohrt, M.; Schoetz, U.; Kuger, S.; Schneider, L.; Schuettrumpf, L.; Jendrossek, Verena; Belka, C.; Zangen, V.; Unger, K.; Zitzelsberger, H.; Lauber, K.; Heß, Jochen A.
    Fanconi anemia, complementation group A (FancA) overexpression confers radioresistance to oral keratinocytes
    In: European Journal of Cancer Vol. 51 (2015) Nr. Suppl.3, pp. 121 - S121
    ISSN: 0959-8049
  • Jendrossek, Verena; Wirsdörfer, Florian; Simone, D. L.; Cappuccini, F.; Therese, E.; Meyer, A.; Karmouty-Quintana, H.; Thompson, L.; Fischer, U.; Kasper, M.; Klein, Diana; Ritchey, J.; Westendorf, Astrid; Stuschke, Martin
    Loss or therapeutic inhibition of extracellular adenosine production by ecto-5 -nucleotidase(CD73) attenuates radiation-induced lung fibrosis
    In: European Journal of Cancer Vol. 51 (2015) Nr. Suppl.3, pp. S117 - S118
    ISSN: 0959-8049
  • Kipkeew, Friederike; Klein, Diana; Wülling, Manuela; Whitley, Guy; Köninger, Angela; Winterhager, Elke; Gellhaus, Alexandra
    CCN3 (NOV) : A key player in trophoblast differentiation promoting cell cycle exit and migration of extravillous trophoblast cells and its role in preeclampsia
    In: Placenta Vol. 35 (2014) Nr. 9, pp. A108
    ISSN: 0143-4004
  • Verhelst, V.; Klein, Diana; Schmitz, T.; Sak, Ali; Jendrossek, Verena
    Importance of stromal caveolin-1 for tumor growth and radiosensitivity of epithelial tumors
    In: European Journal of Cancer Vol. 50 (2014) Nr. 5 Suppl., pp. 224
    ISSN: 0959-8049
  • Klein, Diana; Schmetter, A.; Kleff, V.; Jastrow, Holger; Stuschke, Martin; Jendrossek, Verena
    Mesenchymal stem cell therapy antagonizes radiation-induced endothelial cell damage and metastasis
    In: European Journal of Cancer Vol. 50 (2014) Nr. Suppl. 5, pp. 221
    ISSN: 0959-8049
  • Klein, Diana; Meissner, Nicole; Kleff, Veronika; Jastrow, Holger; Yamaguchi, Masahiro; Süleyman, Ergün; Jendrossek, Verena
    Nestin(+) tissue-resident multipotent stem cells contribute to tumor progression by differentiating into pericytes and smooth muscle cells resulting in blood vessel remodeling
    In: Frontiers in Oncology (2014) Nr. 4, pp. 169
    ISSN: 2234-943X
  • Klein, Diana; Benchellal, Mohamed; Kleff, Veronika; Jakob, Heinz G.; Ergün, Süleyman
    Hox genes are involved in vascular wall-resident multipotent stem cell differentiation into smooth muscle cells
    In: Scientific Reports Vol. 3 (2013) pp. 2178
    ISSN: 2045-2322
  • Weißhardt, Philipp; Trarbach, Tanja; Dürig, Jan; Paul, Andreas; Reis, Henning; Tilki, Derya; Miroschnik, Inna; Ergün, Süleyman; Klein, Diana
    Tumor vessel stabilization and remodeling by anti-angiogenic therapy with bevacizumab
    In: Histochemistry and Cell Biology Vol. 137 (2012) Nr. 3, pp. 391 - 401
    ISSN: 0948-6143; 1432-119X
  • Ergün, Süleyman; Tilki, Derya; Klein, Diana
    Vascular wall as a reservoir for different types of stem and progenitor cells
    In: Antioxidants and Redox Signaling Vol. 15 (2011) Nr. 4, pp. 981 - 995
    ISSN: 1557-7716
  • Klein, Diana; Weisshardt, Philip; Kleff, Veronika; Jastrow, Holger; Jakob, Heinz G.; Ergün, Süleyman
    Vascular wall-resident CD44+ multipotent stem cells give rise to pericytes and smooth muscle cells and contribute to new vessel maturation
    In: PLoS ONE Vol. 6 (2011) Nr. 5, pp. e20540
    ISSN: 1932-6203
  • Géraud, Cyrill; Schledzewski, Kai; Demory, Alexandra; Klein, Diana; Kaus, Miriam; Peyre, Francis; Sticht, Carsten; Evdokimov, Konstantin; Lu, Shun; Schmieder, Astrid; Goerdt, Sergij
    Liver sinusoidal endothelium : a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1
    In: Hepatology Vol. 52 (2010) Nr. 1, pp. 313 - 326
    ISSN: 0270-9139; 1527-3350