ZMB Member Diana Klein
ZMB Member
Diana Klein
Next ZMB-Member
Prof. Dr. Diana Klein
Junior Group
Vascular Remodeling and Normal Tissue ProtectionInstitute of Cell Biology (Tumor Research)
University Hospital Essen
Virchowstr. 173
45122 Essen
- +49 201 723 83342
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- ZMB Research Program
Oncology
Research Overview
Ionizing radiation leads to DNA damage, which primarily causes rapidly proliferating tumor cells to be damaged and killed. In addition, it has been shown in recent years that the tumor microenvironment, and particularly the stromal endothelial cells and fibroblasts play a crucial role in the radiation response and that the tumor stroma could thus be a promising therapeutic target. Thus, understanding the nature of the tumor environment today may be equally important for future cancer therapies as understanding cancer genetics per se. The research work of this junior research group focuses on the importance of endothelial cells (as well as fibroblasts) and therapy-induced vascular remodeling as well as tissue remodelling for radiosensitivity. Herein, crucial signaling molecules/pathways are aimed to be identified that could serve as therapeutically targets (i) to radiosensitize tumor tissue (and thus improve the efficiency of radiation therapy) or (ii) to protect the normal tissue during radiation (to reduce the risk of radiation-induced normal tissue damage).
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Publications
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The vascular nature of lung-resident mesenchymal stem cellsIn: Stem Cells Translational Medicine Vol. 10 (2021) Nr. 1, pp. 128 - 143
ISSN: 2157-6580; 2157-6564Online Full Text: dx.doi.org/ (Open Access) -
Caveolin-1 regulates the ASMase/ceramide-mediated radiation response of endothelial cells in the context of tumor–stroma interactionsIn: Cell Death and Disease Vol. 11 (2020) Nr. 4,
ISSN: 2041-4889Online Full Text: dx.doi.org/ (Open Access) -
Cellular Senescence in the Lung : The Central Role of Senescent Epithelial CellsIn: International Journal of Molecular Sciences Vol. 21 (2020) Nr. 9, pp. 3279
ISSN: 1422-0067; 1661-6596Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Direct conversion of human fibroblasts into therapeutically active vascular wall-typical mesenchymal stem cellsIn: Cellular and Molecular Life Sciences: CMLS Vol. 77 (2020) Nr. 17, pp. 3401 - 3422
ISSN: 1420-682X; 1420-9071Online Full Text: dx.doi.org/ (Open Access) -
Host CD39 Deficiency Affects Radiation-Induced Tumor Growth Delay and Aggravates Radiation-Induced Normal Tissue ToxicityIn: Frontiers in Oncology Vol. 10 (2020) pp. 554883
ISSN: 2234-943XOnline Full Text: dx.doi.org/ Online Full Text (Open Access) -
Lung Multipotent Stem Cells of Mesenchymal Nature : Cellular Basis, Clinical Relevance, and Implications for Stem Cell TherapyIn: Antioxidants and Redox Signaling (2020) in press
ISSN: 1523-0864; 1557-7716Online Full Text: dx.doi.org/ -
Impact of Cancer-Associated Fibroblast on the Radiation-Response of Solid Xenograft TumorsIn: Frontiers in Molecular Biosciences Vol. 6 (2019) pp. 70
ISSN: 2296-889XOnline Full Text: dx.doi.org/ Online Full Text (Open Access) -
Inhibition of Radiation-Induced Ccl2 Signaling Protects Lungs from Vascular Dysfunction and Endothelial Cell LossIn: Antioxidants and Redox Signaling Vol. 30 (2019) Nr. 2, pp. 213 - 231
ISSN: 1523-0864; 1557-7716Online Full Text: dx.doi.org/ -
Progression-Related Loss of Stromal Caveolin 1 Levels Mediates Radiation Resistance in Prostate Carcinoma via the Apoptosis Inhibitor TRIAP1In: Journal of Clinical Medicine Vol. 8 (2019) Nr. 3, pp. 348
ISSN: 2077-0383Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV⁶⁰⁰E inhibition in melanomaIn: European Journal of Cancer Vol. 109 (2019) pp. 137 - 153
ISSN: 1879-0852; 0959-8049Online Full Text: dx.doi.org/ -
Targeting of BRM Sensitizes BRG1-Mutant Lung Cancer Cell Lines to RadiotherapyIn: Molecular Cancer Therapeutics Vol. 18 (2019) Nr. 3, pp. 656 - 666
ISSN: 1538-8514; 1535-7163Online Full Text: dx.doi.org/ -
Caveolin-1, cancer and therapy resistanceIn: International Journal of Cancer Vol. 143 (2018) Nr. 9, pp. 2092 - 2104
ISSN: 0020-7136; 1097-0215Online Full Text: dx.doi.org/ -
Corrigendum : Angelman syndrome-derived neurons display late onset of paternal UBE3A silencingIn: Scientific Reports Vol. 8 (2018) pp. 46952
ISSN: 2045-2322Online Full Text: dx.doi.org/ (Open Access) -
Current Strategies to Generate Human Mesenchymal Stem Cells In VitroIn: Stem Cells International Vol. 2018 (2018) pp. 6726185
ISSN: 1687-9678; 1687-966XOnline Full Text: dx.doi.org/ (Open Access) -
Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxiaIn: Cancer Letters Vol. 439 (2018) pp. 24 - 38
ISSN: 0304-3835Online Full Text: dx.doi.org/ -
The tumor vascular endothelium as decision maker in cancer therapyIn: Frontiers in Oncology Vol. 8 (2018) pp. 00367
ISSN: 2234-943XOnline Full Text: dx.doi.org/ Online Full Text (Open Access) -
iPSCs-based generation of vascular cells : reprogramming approaches and applicationsIn: Cellular and Molecular Life Sciences - CMLS Vol. 75 (2018) Nr. 8, pp. 1411 - 1433
ISSN: 1420-682X; 1420-9071; 0014-4754Online Full Text: dx.doi.org/ (Open Access) -
Activating Akt1 mutations alter DNA double strand break repair and radiosensitivityIn: Scientific Reports Vol. 7 (2017) pp. 42700
ISSN: 2045-2322Online Full Text: dx.doi.org/ (Open Access) -
Genomic amplification of Fanconi anemia complementation group A (FancA) in head and neck squamous cell carcinoma (HNSCC) : Cellular mechanisms of radioresistance and clinical relevanceIn: Cancer letters: an international journal providing a forum for original and pertinent contributions in cancer research Vol. 386 (2017) pp. 87 - 99
ISSN: 0304-3835; 1872-7980Online Full Text: dx.doi.org/ -
In Vitro Generation of Vascular Wall-Resident Multipotent Stem Cells of Mesenchymal Nature from Murine Induced Pluripotent Stem CellsIn: Stem Cell Reports Vol. 8 (2017) Nr. 4, pp. 919 - 932
ISSN: 2213-6711Online Full Text: dx.doi.org/ (Open Access) -
Mesenchymal stem cell therapy protects lungs from radiation-induced endothelial cell loss by restoring superoxide dismutase 1 expressionIn: Antioxidants and Redox Signaling Vol. 26 (2017) Nr. 11, pp. 563 - 582
ISSN: 1523-0864; 1557-7716Online Full Text: dx.doi.org/ (Open Access) -
Progression-related loss of stromal Caveolin 1 levels fosters the growth of human PC3 xenografts and mediates radiation resistanceIn: Scientific Reports Vol. 7 (2017) pp. 41138
ISSN: 2045-2322Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Angelman syndrome-derived neurons display late onset of paternal UBE3A silencingIn: Scientific Reports Vol. 6 (2016) pp. 30792
ISSN: 2045-2322Online Full Text: dx.doi.org/ (Open Access) -
CCN1 (CYR61) and CCN3 (NOV) signaling drives human trophoblast cells into senescence and stimulates migration propertiesIn: Cell Adhesion & Migration Vol. 10 (2016) Nr. 1-2, pp. 163 - 178
ISSN: 1933-6918Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
CCN3 signaling is dysregulated in the pregnancy disorder preeclampsiaIn: Journal of Reproductive Immunology Vol. 115 (2016) pp. 71 - 71
ISSN: 0165-0378Online Full Text: dx.doi.org/ -
Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung FibrosisIn: Cancer Research Vol. 76 (2016) Nr. 10, pp. 3045 - 3056
ISSN: 0008-5472; 1538-7445Online Full Text: dx.doi.org/ (Open Access) -
RHAMM splice variants confer radiosensitivity in human breast cancer cell linesIn: OncoTarget Vol. 7 (2016) Nr. 16, pp. 21428 - 21440
ISSN: 1949-2553Online Full Text: dx.doi.org/ (Open Access) -
Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling HypoxiaIn: Antioxidants and Redox Signaling Vol. 25 (2016) Nr. 2, pp. 89 - 107
ISSN: 1523-0864; 1557-7716Online Full Text: dx.doi.org/ -
Therapy with multipotent mesenchymal stromal cells protects lungs from radiation-induced injury and reduces the risk of lung metastasisIn: Antioxidants and Redox Signaling Vol. 24 (2016) Nr. 2, pp. 53 - 69
ISSN: 1557-7716; 1523-0864Online Full Text: dx.doi.org/ -
Vascular Wall-Resident Multipotent Stem Cells of Mesenchymal Nature within the Process of Vascular Remodeling: Cellular Basis, Clinical Relevance, and Implications for Stem Cell TherapyIn: Stem Cells International Vol. 2016 (2016) pp. 1905846
ISSN: 1687-9678Online Full Text: dx.doi.org/ (Open Access) -
Endothelial Caveolin-1 regulates the radiation response of epithelial prostate tumorsIn: Oncogenesis Vol. 4 (2015) pp. e148
ISSN: 2157-9024Online Full Text: dx.doi.org/ (Open Access) -
Fanconi anemia, complementation group A (FancA) overexpression confers radioresistance to oral keratinocytesIn: European Journal of Cancer Vol. 51 (2015) Nr. Suppl.3, pp. 121 - S121
ISSN: 0959-8049Online Full Text: dx.doi.org/ -
Loss or therapeutic inhibition of extracellular adenosine production by ecto-5 -nucleotidase(CD73) attenuates radiation-induced lung fibrosisIn: European Journal of Cancer Vol. 51 (2015) Nr. Suppl.3, pp. S117 - S118
ISSN: 0959-8049Online Full Text: dx.doi.org/ -
CCN3 (NOV) : A key player in trophoblast differentiation promoting cell cycle exit and migration of extravillous trophoblast cells and its role in preeclampsiaIn: Placenta Vol. 35 (2014) Nr. 9, pp. A108
ISSN: 0143-4004Online Full Text: dx.doi.org/ -
Importance of stromal caveolin-1 for tumor growth and radiosensitivity of epithelial tumorsIn: European Journal of Cancer Vol. 50 (2014) Nr. 5 Suppl., pp. 224
ISSN: 0959-8049Online Full Text: dx.doi.org/ -
Mesenchymal stem cell therapy antagonizes radiation-induced endothelial cell damage and metastasisIn: European Journal of Cancer Vol. 50 (2014) Nr. Suppl. 5, pp. 221
ISSN: 0959-8049Online Full Text: dx.doi.org/ -
Nestin(+) tissue-resident multipotent stem cells contribute to tumor progression by differentiating into pericytes and smooth muscle cells resulting in blood vessel remodelingIn: Frontiers in Oncology (2014) Nr. 4, pp. 169
ISSN: 2234-943XOnline Full Text: dx.doi.org/ (Open Access) -
Hox genes are involved in vascular wall-resident multipotent stem cell differentiation into smooth muscle cellsIn: Scientific Reports Vol. 3 (2013) pp. 2178
ISSN: 2045-2322Online Full Text: dx.doi.org/ (Open Access) -
Tumor vessel stabilization and remodeling by anti-angiogenic therapy with bevacizumabIn: Histochemistry and Cell Biology Vol. 137 (2012) Nr. 3, pp. 391 - 401
ISSN: 0948-6143; 1432-119XOnline Full Text: dx.doi.org/ -
Vascular wall as a reservoir for different types of stem and progenitor cellsIn: Antioxidants and Redox Signaling Vol. 15 (2011) Nr. 4, pp. 981 - 995
ISSN: 1557-7716Online Full Text: dx.doi.org/ -
Vascular wall-resident CD44+ multipotent stem cells give rise to pericytes and smooth muscle cells and contribute to new vessel maturationIn: PLoS ONE Vol. 6 (2011) Nr. 5, pp. e20540
ISSN: 1932-6203Online Full Text: dx.doi.org/ (Open Access) -
Liver sinusoidal endothelium : a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1In: Hepatology Vol. 52 (2010) Nr. 1, pp. 313 - 326
ISSN: 0270-9139; 1527-3350Online Full Text: dx.doi.org/