ZMB member Samuel Peña-Llopis

ZMB Member
Samuel Peña-Llopis

Next ZMB-Member
Samuel Peña-Llopis
© DKFZ/J.Jung

Dr. Samuel Peña-Llopis

Group

Translational Genomics

Department of Ophthalmology
University Hospital Essen
Hufelandstraße 55
45122 Essen

Research Overview

  • Renal Cell Carcinoma and Uveal Melanoma
  • Molecular Genetics and Functional Genomics
  • Bioinformatics
  • Epigenetic Modifier BAP1
  • Patient-derived Organoids
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Selected Publications

    Journal articles

  • Raab, Monika; Győrffy, Balázs; Peña-Llopis, Samuel; Fietz, Daniela; Kressin, Monika; Kolaric, Margareta; Ebert, Matthias; Gasimli, Khayal; Becker, Sven; Sanhaji, Mourad; Strebhardt, Klaus
    Targeted reactivation of the novel tumor suppressor DAPK1, an upstream regulator of p53, in high-grade serous ovarian cancer by mRNA liposomes reduces viability and enhances drug sensitivity in preclinical models
    In: Cancer Communications 2025 , in press
    DOI (Open Access)
  • Montero-Vergara, Jetsy; Plachetta, Kira; Kinch, Lisa; Bernhardt, Stephan; Kashyap, Kriti; Levine, Beth; Thukral, Lipi; Vetter, Martina; Thomssen, Christoph; Wiemann, Stefan; Peña-Llopis, Samuel; Jendrossek, Verena; Vega-Rubin-de-Celis, Silvia
    GRB2 is a BECN1 interacting protein that regulates autophagy
    In: Cell Death and Disease , Vol. 15 2024, Nr. 1, 14
    DOI, Online Full Text (Open Access)
  • Gasimli, Khayal; Raab, Monika; Mandal, Ranadip; Krämer, Andrea; Peña-Llopis, Samuel; Tahmasbi Rad, Morva; Becker, Sven; Strebhardt, Klaus; Sanhaji, Mourad
    Synergistic Sensitization of High-Grade Serous Ovarian Cancer Cells Lacking Caspase-8 Expression to Chemotherapeutics Using Combinations of Small-Molecule BRD4 and CDK9 Inhibitors
    In: Cancers , Vol. 16 2024, Nr. 1, 107
    DOI (Open Access)
  • Mandal, Ranadip; Raab, Monika; Rödel, Franz; Krämer, Andrea; Kostova, Izabela; Peña-Llopis, Samuel; Medici, Gioele; Häupl, Björn; Oellerich, Thomas; Gasimli, Khayal; Sanhaji, Mourad; Becker, Sven; Strebhardt, Klaus
    Correction : The non-apoptotic function of Caspase-8 in negatively regulating the CDK9-mediated Ser2 phosphorylation of RNA polymerase II in cervical cancer
    In: Cellular and Molecular Life Sciences - CMLS , Vol. 80 2023, Nr. 3, 64
    DOI (Open Access)
  • Raab, Monika; Kostova, Izabela; Peña-Llopis, Samuel; Fietz, Daniela; Kressin, Monika; Aberoumandi, Seyed Mohsen; Ullrich, Evelyn; Becker, Sven; Sanhaji, Mourad; Strebhardt, Klaus
    Rescue of p53 functions by in vitro-transcribed mRNA impedes the growth of high-grade serous ovarian cancer
    In: Cancer Communications , Vol. 44 2023, Nr. 1, pp. 101 – 126
    DOI (Open Access)
  • Mergener, Svenja; Peña-Llopis, Samuel
    A new perspective on immune evasion : Escaping immune surveillance by inactivating tumor suppressors
    In: Signal Transduction and Targeted Therapy , Vol. 7 2022, Nr. 1, 15
    DOI (Open Access)
  • Hegedüs, Luca; Szücs, Kata D.; Kudla, Matthias; Heidenreich, Julian; Jendrossek, Verena; Peña-Llopis, Samuel; Garay, Tamas; Czirok, Andras; Aigner, Clemens; Plönes, Till; Vega-Rubin-de-Celis, Silvia; Hegedüs, Balazs
    Nintedanib and Dasatinib Treatments Induce Protective Autophagy as a Potential Resistance Mechanism in MPM Cells
    In: Frontiers in Cell and Developmental Biology , Vol. 10 2022, 852812
    DOI, Online Full Text (Open Access)
  • Mandal, Ranadip; Raab, Monika; Rödel, Franz; Krämer, Andrea; Kostova, Izabela; Peña-Llopis, Samuel; Häupl, Björn; Oellerich, Thomas; Gasimli, Khayal; Sanhaji, Mourad; Becker, Sven; Strebhardt, Klaus
    The non-apoptotic function of Caspase-8 in negatively regulating the CDK9-mediated Ser2 phosphorylation of RNA polymerase II in cervical cancer
    In: Cellular and Molecular Life Sciences - CMLS , Vol. 79 2022, Nr. 12, 597
    DOI (Open Access)
  • Niersch, Jennifer; Vega-Rubín-de-Celis, Silvia; Bazarna, Anna; Mergener, Svenja; Jendrossek, Verena; Siveke, Jens; Peña-Llopis, Samuel
    A BAP1 synonymous mutation results in exon skipping, loss of function and worse patient prognosis
    In: iScience , Vol. 24 2021, Nr. 3, 102173
    DOI (Open Access)
  • Peña-Llopis, Samuel
    Leadership challenges defused
    In: Science , Vol. 371 2021, Nr. 6533, pp. 1070
    DOI (Open Access)
  • Mergener, Svenja; Siveke, Jens; Peña-Llopis, Samuel
    Monosomy 3 is linked to resistance to mek inhibitors in uveal melanoma
    In: International Journal of Molecular Sciences (IJMS) , Vol. 22 2021, Nr. 13, 6727
    DOI (Open Access)
  • Vega-Rubín-de-Celis, Silvia; Kinch, Lisa; Peña-Llopis, Samuel
    Regulation of beclin 1-mediated autophagy by oncogenic tyrosine kinases
    In: International Journal of Molecular Sciences (IJMS) , Vol. 21 2020, Nr. 23, pp. 9210
    DOI, Online Full Text (Open Access)
  • Zhao, Ben; Dierichs, Laura; Gu, Jiang-Ning; Trajkovic-Arsic, Marija; Axel Hilger, Ralf; Savvatakis, Konstantinos; Vega-Rubín-de-Celis, Silvia; Liffers, Sven-Thorsten; Peña-Llopis, Samuel; Behrens, Diana; Hahn, Stephan; Siveke, Jens; Lueong, Smiths S.
    TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancer
    In: Cell Death Discovery , Vol. 6 2020, Nr. 1, 12
    DOI (Open Access)
  • Fleischmann, Max; Martin, Daniel; Peña-Llopis, Samuel; Oppermann, Julius; von der Grün, Jens; Diefenhardt, Markus; Chatzikonstantinou, Georgios; Fokas, Emmanouil; Rödel, Claus; Strebhardt, Klaus; Becker, Sven; Rödel, Franz; Tselis, Nikolaos
    Association of Polo-Like Kinase 3 and PhosphoT273 Caspase 8 Levels With Disease-Related Outcomes Among Cervical Squamous Cell Carcinoma Patients Treated With Chemoradiation and Brachytherapy
    In: Frontiers in Oncology , Vol. 9 2019, pp. 742
    DOI (Open Access)
  • Trošt, Nuša; Peña-Llopis, Samuel; Koirala, Sajjan; Stojan, Jurij; Potts, Patrick Ryan; Fon Tacer, Klementina; Martinez, Elisabeth D.
    Correction: : γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers
    In: OncoTarget , Vol. 10 2019, Nr. 8, pp. 916 – 916
    DOI (Open Access)
  • Tapia-Laliena, María Ángeles; Korzeniewski, Nina; Peña-Llopis, Samuel; Scholl, Claudia; Fröhling, Stefan; Hohenfellner, Markus; Duensing, Anette; Duensing, Stefan
    Cullin 5 is a novel candidate tumor suppressor in renal cell carcinoma involved in the maintenance of genome stability
    In: Oncogenesis , Vol. 8 2019, Nr. 1, pp. 4
    DOI (Open Access)
  • Bayo, Juan; Tran, Tram Anh; Wang, Lei; Peña-Llopis, Samuel; Das, Amit K.; Martinez, Elisabeth D.
    Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks
    In: Cell Reports , Vol. 25 2018, Nr. 4, pp. 1040 – 1050.e5
    DOI (Open Access)
  • Vega-Rubín-de-Celis, Silvia; Peña-Llopis, Samuel; Konda, Meghan; Brugarolas, James
    Multistep regulation of TFEB by MTORC1
    In: Autophagy , Vol. 13 2017, Nr. 3, pp. 464 – 472
    DOI (Open Access)
  • Park, Sunho; Kim, Seung-Jun; Yu, Donghyeon; Peña-Llopis, Samuel; Gao, Jianjiong; Park, Jin Suk; Chen, Beibei; Norris, Jessie; Wang, Xinlei; Chen, Min; Kim, Minsoo; Yong, Jeongsik; Wardak, Zabi; Choe, Kevin; Story, Michael; Starr, Timothy; Cheong, Jae-Ho; Hwang, Tae Hyun
    An integrative somatic mutation analysis to identify pathways linked with survival outcomes across 19 cancer types
    In: Bioinformatics , Vol. 32 2016, Nr. 11, pp. 1643 – 1651
    DOI
  • Tran, Tram Anh; Leong, Hon Sing; Pavia-Jimenez, Andrea; Fedyshyn, Slavic; Yang, Juan; Kucejova, Blanka; Sivanand, Sharanya; Spence, Patrick; Xie, Xian-Jin; Peña-Llopis, Samuel; Power, Nicholas; Brugarolas, James
    Fibroblast growth factor receptor-dependent and -independent paracrine signaling by sunitinib-resistant renal cell carcinoma
    In: Molecular and Cellular Biology (MCB) , Vol. 36 2016, Nr. 13, pp. 1836 – 1855
    DOI
  • Cheng, Wing Yin; Huynh, Hoangdinh; Chen, Peiwen; Peña-Llopis, Samuel; Wan, Yihong
    Macrophage PPARγ inhibits GPR132 to mediate the anti-tumor effects of rosiglitazone
    In: eLife , Vol. 5 2016, pp. e18501
    DOI (Open Access)
  • Peña-Llopis, Samuel; Wan, Yihong; Martinez, Elisabeth D.
    Unique epigenetic gene profiles define human breast cancers with poor prognosis
    In: OncoTarget , Vol. 7 2016, Nr. 52, pp. 85819 – 85831
    DOI
  • Trošt, Nuša; Peña-Llopis, Samuel; Koirala, Sajjan; Stojan, Jurij; Potts, Patrick Ryan; Tacer, Klementina Fon; Martinez, Elisabeth D.
    γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers
    In: OncoTarget , Vol. 7 2016, Nr. 3, pp. 2611 – 2628
    DOI (Open Access)
  • Gayed, Bishoy A; Gillen, Jessica; Christie, Alana; Peña-Llopis, Samuel; Xie, Xian-Jin; Yan, Jingsheng; Karam, Jose A; Raj, Ganesh; Sagalowsky, Arthur I; Lotan, Yair; Margulis, Vitaly; Brugarolas, James
    Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma Urological oncology
    In: BMC Urology , Vol. 15 2015, Nr. 1, pp. 1 – 8
    DOI (Open Access)
  • Durinck, Steffen; Stawiski, Eric W.; Pavía-Jiménez, Andrea; Modrusan, Zora; Kapur, Payal; Jaiswal, Bijay S.; Zhang, Na; Toffessi-Tcheuyap, Vanina; Nguyen, Thong T.; Pahuja, Kanika Bajaj; Chen, Ying-Jiun; Saleem, Sadia; Chaudhuri, Subhra; Heldens, Sherry; Jackson, Marlena; Peña-Llopis, Samuel; Guillory, Joseph; Toy, Karen; Ha, Connie; Harris, Corissa J.; Holloman, Eboni; Hill, Haley M.; Stinson, Jeremy; Rivers, Celina Sanchez; Janakiraman, Vasantharajan; Wang, Weiru; Kinch, Lisa N.; Grishin, Nick V.; Haverty, Peter M.; Chow, Bernard; Gehring, Julian S.; Reeder, Jens; Pau, Gregoire; Wu, Thomas D.; Margulis, Vitaly; Lotan, Yair; Sagalowsky, Arthur; Pedrosa, Ivan; De Sauvage, Frederic J.; Brugarolas, James; Seshagiri, Somasekar
    Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes
    In: Nature Genetics , Vol. 47 2015, Nr. 1, pp. 13 – 21
    DOI (Open Access)
  • Peña-Llopis, Samuel; Serrano, Roque; Pitarch, Elena; Beltrán, Eduardo; Ibáñez, María; Hernández, Félix; Peña, Juan B.
    N-Acetylcysteine boosts xenobiotic detoxification in shellfish
    In: Aquatic Toxicology , Vol. 154 2014, pp. 131 – 140
    DOI
  • Schuster, Katja; Venkateswaran, Niranjan; Rabellino, Andrea; Girard, Luc; Peña-Llopis, Samuel; Scaglioni, Pier Paolo
    Nullifying the CDKN2AB locus promotes mutant K-ras lung tumorigenesis
    In: Molecular Cancer Research , Vol. 12 2014, Nr. 6, pp. 912 – 923
    DOI (Open Access)
  • Farley, Megan N.; Schmidt, Laura S.; Mester, Jessica L.; Peña-Llopis, Samuel; Pavia-Jimenez, Andrea; Christie, Alana; Vocke, Cathy D.; Ricketts, Christopher J.; Peterson, James; Middelton, Lindsay; Kinch, Lisa; Grishin, Nick; Merino, Maria J.; Metwalli, Adam R.; Xing, Chao; Xie, Xian-Jin; Dahia, Patricia L.M.; Eng, Charis; Linehan, W. Marston; Brugarolas, James
    A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma
    In: Molecular Cancer Research , Vol. 11 2013, Nr. 9, pp. 1061 – 1071
    DOI (Open Access)
  • Wang, Lei; Chang, Jianjun; Varghese, Diana; Dellinger, Michael; Kumar, Subodh; Best, Anne M.; Ruiz, Julio; Bruick, Richard; Peña-Llopis, Samuel; Xu, Junjie; Babinski, David J.; Frantz, Doug E.; Brekken, Rolf A.; Quinn, Amy M.; Simeonov, Anton; Easmon, Johnny; Martinez, Elisabeth D.
    A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth
    In: Nature Communications , Vol. 4 2013, pp. 2035
    DOI (Open Access)
  • Peña-Llopis, Samuel; Christie, Alana; Xie, Xian-Jin; Brugarolas, James
    Cooperation and antagonism among cancer genes: The renal cancer paradigm
    In: Cancer Research , Vol. 73 2013, Nr. 14, pp. 4173 – 4179
    DOI (Open Access)
  • Kapur, Payal; Peña-Llopis, Samuel; Christie, Alana; Zhrebker, Leah; Pavía-Jiménez, Andrea; Rathmell, W Kimryn; Xie, Xian-Jin; Brugarolas, James
    Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: A retrospective analysis with independent validation
    In: The Lancet Oncology , Vol. 14 2013, Nr. 2, pp. 159 – 167
    DOI (Open Access)
  • Tran, Tram Anh; Kinch, Lisa; Peña-Llopis, Samuel; Kockel, Lutz; Grishin, Nick; Jiang, Huaqi; Brugarolas, James
    Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1
    In: Molecular and Cellular Biology (MCB) , Vol. 33 2013, Nr. 19, pp. 3762 – 3779
    DOI
  • Peña-Llopis, Samuel; Brugarolas, James
    Simultaneous isolation of high-quality DNA, RNA, miRNA and proteins from tissues for genomic applications
    In: Nature Protocols , Vol. 8 2013, Nr. 11, pp. 2240 – 2255
    DOI (Open Access)
  • Sivanand, Sharanya; Peña-Llopis, Samuel; Zhao, Hong; Kucejova, Blanka; Spence, Patrick; Pavia-Jimenez, Andrea; Yamasaki, Toshinari; McBride, David J.; Gillen, Jessica; Wolff, Nicholas C.; Morlock, Lorraine; Lotan, Yair; Raj, Ganesh V.; Sagalowsky, Arthur; Margulis, Vitaly; Cadeddu, Jeffrey A.; Ross, Mark T.; Bentley, David R.; Kabbani, Wareef; Xie, Xian-Jin; Kapur, Payal; Williams, Noelle S.; Brugarolas, James
    A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma
    In: Science Translational Medicine , Vol. 4 2012, Nr. 137, 137ra75
    DOI (Open Access)
  • Peña-Llopis, Samuel; Vega-Rubín-de-Celis, Silvia; Liao, Arnold; Leng, Nan; Pavía-Jiménez, Andrea; Wang, Shanshan; Yamasaki, Toshinari; Zhrebker, Leah; Sivanand, Sharanya; Spence, Patrick; Kinch, Lisa; Hambuch, Tina; Jain, Suneer; Lotan, Yair; Margulis, Vitaly; Sagalowsky, Arthur I.; Summerour, Pia Banerji; Kabbani, Wareef; Wong, S W Wendy; Grishin, Nick; Laurent, Marc; Xie, Xian-Jin; Haudenschild, Christian D.; Ross, Mark T.; Bentley, David R.; Kapur, Payal; Brugarolas, James
    BAP1 loss defines a new class of renal cell carcinoma
    In: Nature Genetics , Vol. 44 2012, Nr. 7, pp. 751 – 759
    DOI (Open Access)
  • Mata, Miguel A.; Satterly, Neal; Versteeg, Gijs A.; Frantz, Doug; Wei, Shuguang; Williams, Noelle; Schmolke, Mirco; Peña-Llopis, Samuel; Brugarolas, James; Forst, Christian V.; White, Michael A; García-Sastre, Adolfo; Roth, Michael G.; Fontoura, Beatriz M. A.
    Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor
    In: Nature Chemical Biology , Vol. 7 2011, Nr. 10, pp. 712 – 719
    DOI
  • Kucejova, Blanka; Peña-Llopis, Samuel; Yamasaki, Toshinari; Sivanand, Sharanya; Tran, Tram Anh T.; Alexander, Shane; Wolff, Nicholas C.; Lotan, Yair; Xie, Xian-Jin; Kabbani, Wareef; Kapur, Payal; Brugarolas, James
    Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma
    In: Molecular Cancer Research , Vol. 9 2011, Nr. 9, pp. 1255 – 1265
    DOI (Open Access)
  • Peña-Llopis, Samuel; Vega-Rubín-de-Celis, Silvia; Schwartz, Jacob C.; Wolff, Nicholas C.; Tran, Tram Anh T.; Zou, Lihua; Xie, Xian-Jin; Corey, David R.; Brugarolas, James
    Regulation of TFEB and V-ATPases by mTORC1
    In: The EMBO Journal , Vol. 30 2011, Nr. 16, pp. 3242 – 3258
    DOI (Open Access)
  • Kucejova, B.; Sunny, N.E.; Nguyen, A.D.; Hallac, R.; Fu, X.; Pẽa-Llopis, S.; Mason, R.P.; Deberardinis, R.J.; Xie, X.-J.; Debose-Boyd, R.; Kodibagkar, V.D.; Burgess, S.C.; Brugarolas, J.; Peña-Llopis, Samuel
    Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death
    In: Oncogene , Vol. 30 2011, Nr. 18, pp. 2147 – 2160
    DOI (Open Access)
  • Lee, Yunho; Peña-Llopis, Samuel; Kang, Yoon-Suk; Shin, Hyeon-Dong; Demple, Bruce; Madsen, Eugene L.; Jeon, Che Ok; Park, Woojun
    Expression analysis of the fpr (ferredoxin-NADP⁺ reductase) gene in Pseudomonas putida KT2440
    In: Biochemical and Biophysical Research Communications (BBRC) , Vol. 339 2006, Nr. 4, pp. 1246 – 1254
    DOI
  • Park, Woojun; Peña-Llopis, Samuel; Lee, Yunho; Demple, Bruce
    Regulation of superoxide stress in Pseudomonas putida KT2440 is different from the SoxR paradigm in Escherichia coli
    In: Biochemical and Biophysical Research Communications (BBRC) , Vol. 341 2006, Nr. 1, pp. 51 – 56
    DOI
  • Peña-Llopis, Samuel
    Antioxidants as Potentially Safe Antidotes for Organophosphorus Poisoning
    In: Current Enzyme Inhibition , Vol. 1 2005, Nr. 2, pp. 147 – 156
    DOI
  • Koutsolioutsou, Anastasia; Peña-Llopis, Samuel; Demple, Bruce
    Constitutive soxR mutations contribute to multiple-antibiotic resistance in clinical Escherichia coli isolates
    In: Antimicrobial Agents and Chemotherapy , Vol. 49 2005, Nr. 7, pp. 2746 – 2752
    DOI (Open Access)
  • Sitjà-Bobadilla, A.; Peña-Llopis, Samuel; Gómez-Requeni, P.; Médale, F.; Kaushik, S.; Pérez-Sánchez, J.
    Effect of fish meal replacement by plant protein sources on non-specific defence mechanisms and oxidative stress in gilthead sea bream (Sparus aurata)
    In: Aquaculture , Vol. 249 2005, Nr. 1-4, pp. 387 – 400
    DOI (Open Access)
  • Peña-Llopis, Samuel; Ferrando, M. Dolores; Peña, Juan B.; Ferrando, M.Dolores
    Fish tolerance to organophosphate-induced oxidative stress is dependent on the glutathione metabolism and enhanced by N-acetylcysteine
    In: Aquatic Toxicology , Vol. 65 2003, Nr. 4, pp. 337 – 360
    DOI
  • Peña-Llopis, Samuel; Dolores Ferrando, Ma.; Peña, Juan B.; Ferrando, MD; Peña, JB
    Increased recovery of brain acetylcholinesterase activity in dichlorvos-intoxicated European eels Anguilla anguilla by bath treatment with N-acetylcysteine
    In: Diseases of Aquatic Organisms , Vol. 55 2003, Nr. 3, pp. 237 – 245
    DOI (Open Access)
  • Pea-Llopis, S.; Ferrando, M.D.; Pea, J.B.; Peña-Llopis, Samuel; Peña, J.B.
    Impaired glutathione redox status is associated with decreased survival in two organophosphate-poisoned marine bivalves
    In: Chemosphere , Vol. 47 2002, Nr. 5, pp. 485 – 497
    DOI
  • Pea-Llopis, S.; Pea, J.B.; Sancho, E.; Fernández-Vega, C.; Ferrando, M.D.; Peña-Llopis, Samuel; Peña, J.B.
    Glutathione-dependent resistance of the European eel Anguilla anguilla to the herbicide molinate
    In: Chemosphere , Vol. 45 2001, Nr. 4-5, pp. 671 – 681
    DOI
  • Peña-Llopis, Samuel; Peña, J.B.; Ríos, C.; Sancho, E.; Fernández, C.; Ferrando, M.D.
    Role of glutathione in thiobencarb resistance in the European eel Anguilla anguilla
    In: Ecotoxicology and Environmental Safety , Vol. 46 2000, Nr. 1, pp. 51 – 56
    DOI
  • Pena, Juan; Rios, Concha; Peña-Llopis, Samuel
    Ultrastructural morphogenesis of pectinid spat from the western Mediterranean : A way to differentiate seven genera
    In: Journal of Shellfish Research , Vol. 17 1998, Nr. 1-3, pp. 123 – 130
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