ZMB member Samuel Peña-Llopis
ZMB Member
Samuel Peña-Llopis
Next ZMB-Member
Dr. Samuel Peña-Llopis
Group
Translational GenomicsDepartment of Ophthalmology
University Hospital Essen
Hufelandstraße 55
45122 Essen
- +49 201 723 7312
- Website
- Selected Publications
- Publication Metrics
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- ZMB Research Program
Oncology
Research Overview
- Renal Cell Carcinoma and Uveal Melanoma
- Molecular Genetics and Functional Genomics
- Bioinformatics
- Epigenetic Modifier BAP1
- Patient-derived Organoids
Selected Publications
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Targeted reactivation of the novel tumor suppressor DAPK1, an upstream regulator of p53, in high-grade serous ovarian cancer by mRNA liposomes reduces viability and enhances drug sensitivity in preclinical modelsIn: Cancer Communications 2025 , in pressDOI (Open Access)
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GRB2 is a BECN1 interacting protein that regulates autophagyIn: Cell Death and Disease , Vol. 15 2024, Nr. 1, 14DOI, Online Full Text (Open Access)
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Synergistic Sensitization of High-Grade Serous Ovarian Cancer Cells Lacking Caspase-8 Expression to Chemotherapeutics Using Combinations of Small-Molecule BRD4 and CDK9 InhibitorsIn: Cancers , Vol. 16 2024, Nr. 1, 107DOI (Open Access)
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Correction : The non-apoptotic function of Caspase-8 in negatively regulating the CDK9-mediated Ser2 phosphorylation of RNA polymerase II in cervical cancerIn: Cellular and Molecular Life Sciences - CMLS , Vol. 80 2023, Nr. 3, 64DOI (Open Access)
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Rescue of p53 functions by in vitro-transcribed mRNA impedes the growth of high-grade serous ovarian cancerIn: Cancer Communications , Vol. 44 2023, Nr. 1, pp. 101 – 126DOI (Open Access)
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A new perspective on immune evasion : Escaping immune surveillance by inactivating tumor suppressorsIn: Signal Transduction and Targeted Therapy , Vol. 7 2022, Nr. 1, 15DOI (Open Access)
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Nintedanib and Dasatinib Treatments Induce Protective Autophagy as a Potential Resistance Mechanism in MPM CellsIn: Frontiers in Cell and Developmental Biology , Vol. 10 2022, 852812DOI, Online Full Text (Open Access)
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The non-apoptotic function of Caspase-8 in negatively regulating the CDK9-mediated Ser2 phosphorylation of RNA polymerase II in cervical cancerIn: Cellular and Molecular Life Sciences - CMLS , Vol. 79 2022, Nr. 12, 597DOI (Open Access)
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A BAP1 synonymous mutation results in exon skipping, loss of function and worse patient prognosisIn: iScience , Vol. 24 2021, Nr. 3, 102173DOI (Open Access)
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Monosomy 3 is linked to resistance to mek inhibitors in uveal melanomaIn: International Journal of Molecular Sciences (IJMS) , Vol. 22 2021, Nr. 13, 6727DOI (Open Access)
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Regulation of beclin 1-mediated autophagy by oncogenic tyrosine kinasesIn: International Journal of Molecular Sciences (IJMS) , Vol. 21 2020, Nr. 23, pp. 9210DOI, Online Full Text (Open Access)
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TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancerIn: Cell Death Discovery , Vol. 6 2020, Nr. 1, 12DOI (Open Access)
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Association of Polo-Like Kinase 3 and PhosphoT273 Caspase 8 Levels With Disease-Related Outcomes Among Cervical Squamous Cell Carcinoma Patients Treated With Chemoradiation and BrachytherapyIn: Frontiers in Oncology , Vol. 9 2019, pp. 742DOI (Open Access)
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Correction: : γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancersIn: OncoTarget , Vol. 10 2019, Nr. 8, pp. 916 – 916DOI (Open Access)
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Cullin 5 is a novel candidate tumor suppressor in renal cell carcinoma involved in the maintenance of genome stabilityIn: Oncogenesis , Vol. 8 2019, Nr. 1, pp. 4DOI (Open Access)
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Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand BreaksIn: Cell Reports , Vol. 25 2018, Nr. 4, pp. 1040 – 1050.e5DOI (Open Access)
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Multistep regulation of TFEB by MTORC1In: Autophagy , Vol. 13 2017, Nr. 3, pp. 464 – 472DOI (Open Access)
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An integrative somatic mutation analysis to identify pathways linked with survival outcomes across 19 cancer typesIn: Bioinformatics , Vol. 32 2016, Nr. 11, pp. 1643 – 1651
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Fibroblast growth factor receptor-dependent and -independent paracrine signaling by sunitinib-resistant renal cell carcinomaIn: Molecular and Cellular Biology (MCB) , Vol. 36 2016, Nr. 13, pp. 1836 – 1855
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Macrophage PPARγ inhibits GPR132 to mediate the anti-tumor effects of rosiglitazoneIn: eLife , Vol. 5 2016, pp. e18501DOI (Open Access)
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Unique epigenetic gene profiles define human breast cancers with poor prognosisIn: OncoTarget , Vol. 7 2016, Nr. 52, pp. 85819 – 85831
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γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancersIn: OncoTarget , Vol. 7 2016, Nr. 3, pp. 2611 – 2628DOI (Open Access)
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Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma Urological oncologyIn: BMC Urology , Vol. 15 2015, Nr. 1, pp. 1 – 8DOI (Open Access)
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Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypesIn: Nature Genetics , Vol. 47 2015, Nr. 1, pp. 13 – 21DOI (Open Access)
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N-Acetylcysteine boosts xenobiotic detoxification in shellfishIn: Aquatic Toxicology , Vol. 154 2014, pp. 131 – 140
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Nullifying the CDKN2AB locus promotes mutant K-ras lung tumorigenesisIn: Molecular Cancer Research , Vol. 12 2014, Nr. 6, pp. 912 – 923DOI (Open Access)
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A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinomaIn: Molecular Cancer Research , Vol. 11 2013, Nr. 9, pp. 1061 – 1071DOI (Open Access)
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A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growthIn: Nature Communications , Vol. 4 2013, pp. 2035DOI (Open Access)
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Cooperation and antagonism among cancer genes: The renal cancer paradigmIn: Cancer Research , Vol. 73 2013, Nr. 14, pp. 4173 – 4179DOI (Open Access)
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Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: A retrospective analysis with independent validationIn: The Lancet Oncology , Vol. 14 2013, Nr. 2, pp. 159 – 167DOI (Open Access)
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Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1In: Molecular and Cellular Biology (MCB) , Vol. 33 2013, Nr. 19, pp. 3762 – 3779
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Simultaneous isolation of high-quality DNA, RNA, miRNA and proteins from tissues for genomic applicationsIn: Nature Protocols , Vol. 8 2013, Nr. 11, pp. 2240 – 2255DOI (Open Access)
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A validated tumorgraft model reveals activity of dovitinib against renal cell carcinomaIn: Science Translational Medicine , Vol. 4 2012, Nr. 137, 137ra75DOI (Open Access)
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BAP1 loss defines a new class of renal cell carcinomaIn: Nature Genetics , Vol. 44 2012, Nr. 7, pp. 751 – 759DOI (Open Access)
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Chemical inhibition of RNA viruses reveals REDD1 as a host defense factorIn: Nature Chemical Biology , Vol. 7 2011, Nr. 10, pp. 712 – 719
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Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinomaIn: Molecular Cancer Research , Vol. 9 2011, Nr. 9, pp. 1255 – 1265DOI (Open Access)
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Regulation of TFEB and V-ATPases by mTORC1In: The EMBO Journal , Vol. 30 2011, Nr. 16, pp. 3242 – 3258DOI (Open Access)
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Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic deathIn: Oncogene , Vol. 30 2011, Nr. 18, pp. 2147 – 2160DOI (Open Access)
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Expression analysis of the fpr (ferredoxin-NADP⁺ reductase) gene in Pseudomonas putida KT2440In: Biochemical and Biophysical Research Communications (BBRC) , Vol. 339 2006, Nr. 4, pp. 1246 – 1254
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Regulation of superoxide stress in Pseudomonas putida KT2440 is different from the SoxR paradigm in Escherichia coliIn: Biochemical and Biophysical Research Communications (BBRC) , Vol. 341 2006, Nr. 1, pp. 51 – 56
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Antioxidants as Potentially Safe Antidotes for Organophosphorus PoisoningIn: Current Enzyme Inhibition , Vol. 1 2005, Nr. 2, pp. 147 – 156
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Constitutive soxR mutations contribute to multiple-antibiotic resistance in clinical Escherichia coli isolatesIn: Antimicrobial Agents and Chemotherapy , Vol. 49 2005, Nr. 7, pp. 2746 – 2752DOI (Open Access)
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Effect of fish meal replacement by plant protein sources on non-specific defence mechanisms and oxidative stress in gilthead sea bream (Sparus aurata)In: Aquaculture , Vol. 249 2005, Nr. 1-4, pp. 387 – 400DOI (Open Access)
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Fish tolerance to organophosphate-induced oxidative stress is dependent on the glutathione metabolism and enhanced by N-acetylcysteineIn: Aquatic Toxicology , Vol. 65 2003, Nr. 4, pp. 337 – 360
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Increased recovery of brain acetylcholinesterase activity in dichlorvos-intoxicated European eels Anguilla anguilla by bath treatment with N-acetylcysteineIn: Diseases of Aquatic Organisms , Vol. 55 2003, Nr. 3, pp. 237 – 245DOI (Open Access)
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Impaired glutathione redox status is associated with decreased survival in two organophosphate-poisoned marine bivalvesIn: Chemosphere , Vol. 47 2002, Nr. 5, pp. 485 – 497
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Glutathione-dependent resistance of the European eel Anguilla anguilla to the herbicide molinateIn: Chemosphere , Vol. 45 2001, Nr. 4-5, pp. 671 – 681
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Role of glutathione in thiobencarb resistance in the European eel Anguilla anguillaIn: Ecotoxicology and Environmental Safety , Vol. 46 2000, Nr. 1, pp. 51 – 56
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Ultrastructural morphogenesis of pectinid spat from the western Mediterranean : A way to differentiate seven generaIn: Journal of Shellfish Research , Vol. 17 1998, Nr. 1-3, pp. 123 – 130