ZMB Member Wiebke Hansen
ZMB Member
Wiebke Hansen
Next ZMB-Member
Prof. Dr. Wiebke Hansen
Institute of Medical Microbiology
University Hospital Essen
Hufelandstr. 55
45122 Essen
- +49 201 723 1827
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- Selected Publications
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- ZMB Research Program
Immunology, Infectious Diseases and Transplantation
Research Overview
The immune system's job is to ward off a multitude of invading pathogens such as bacteria, viruses and parasites. These defense mechanisms must be precisely controlled in order to prevent an excessive inflammatory response, which can lead to immunological pathologies and autoimmune diseases.
The working group "Molecular Infection Immunology" is concerned with mechanisms that are involved in the control of immune responses in infections, especially malaria and inflammatory processes. The focus is on T lymphocytes, which are divided into effector T cells and regulatory T cells. While effector T cells promote immune reactions, regulatory T cells have immunosuppressive abilities and are thus able to control immune responses. Based on molecular and functional investigations, we are working to identify target structures that allow the function of T cells to be modified for therapeutic applications. In addition to Neuropilin-1 and CD83, promising molecules are also members of the sphingolipid signaling pathway.
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Selected Publications
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An Early Wave of Macrophage Infiltration Intertwined with Antigen-Specific Proinflammatory T Cells and Browning of Adipose Tissue Characterizes the Onset of Orbital Inflammation in a Mouse Model of Graves' OrbitopathyIn: Thyroid Vol. 32 (2022) Nr. 3, pp. 283 - 293
ISSN: 1557-9077; 1050-7256Online Full Text: dx.doi.org/ -
GPR15 facilitates recruitment of regulatory T cells to promote colorectal cancerIn: Cancer Research Vol. 81 (2021) Nr. 11, pp. 2970 - 2982
ISSN: 1538-7445; 0008-5472Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access) -
IL-33 Drives Expansion of Type 2 Innate Lymphoid Cells and Regulatory T Cells and Protects Mice From Severe, Acute ColitisIn: Frontiers in Immunology Vol. 12 (2021)
ISSN: 1664-3224Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Interleukin-33 signaling exacerbates experimental infectious colitis by enhancing gut permeability and inhibiting protective Th17 immunityIn: Mucosal Immunology Vol. 14 (2021) Nr. 4, pp. 923 - 936
ISSN: 1933-0219; 1935-3456Online Full Text: dx.doi.org/ (Open Access) -
CEACAM1 regulates CD8⁺ T cell immunity and protects from severe pathology during Citrobacter rodentium induced colitisIn: Gut Microbes Vol. 11 (2020) Nr. 6, pp. 1790 - 1805
ISSN: 1949-0984; 1949-0976Online Full Text: dx.doi.org/ -
Endogenous CD83 Expression in CD4⁺ Conventional T Cells Controls Inflammatory Immune ResponsesIn: The Journal of Immunology Vol. 204 (2020) Nr. 12, pp. 3217 - 3226
ISSN: 1550-6606; 0022-1767; 1047-7381; 1048-3233Online Full Text: dx.doi.org/ (Open Access) -
Fingolimod Improves the Outcome of Experimental Graves' Disease and Associated Orbitopathy by Modulating the Autoimmune Response to the Thyroid-Stimulating Hormone ReceptorIn: Thyroid Vol. 29 (2019) Nr. 9, pp. 1286 - 1301
ISSN: 1557-9077; 1050-7256Online Full Text: dx.doi.org/ -
Intestinal acid sphingomyelinase protects from severe pathogen-driven colitisIn: Frontiers in Immunology Vol. 10 (2019) pp. 1386
ISSN: 1664-3224Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
MicroRNA-183 and microRNA-96 are associated with autoimmune responses by regulating T cell activationIn: Journal of Autoimmunity Vol. 96 (2019) pp. 94 - 103
ISSN: 1095-9157; 0896-8411Online Full Text: dx.doi.org/ -
T cell-specific overexpression of acid sphingomyelinase results in elevated T cell activation and reduced parasitemia during Plasmodium yoelii infectionIn: Frontiers in Immunology Vol. 10 (2019) pp. 1225
ISSN: 1664-3224Online Full Text: dx.doi.org/ (Open Access) -
The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancerIn: Mucosal Immunology Vol. 12 (2019) Nr. 4, pp. 990 - 1003
ISSN: 1933-0219; 1935-3456Online Full Text: dx.doi.org/ (Open Access) -
Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8+ T Cell Responses During Chronic Retroviral InfectionIn: Frontiers in Immunology Vol. 9 (2018)
ISSN: 1664-3224Online Full Text: dx.doi.org/ (Open Access) -
Peripheral T cell depletion by FTY720 exacerbates hypoxic-ischemic brain injury in neonatal miceIn: Frontiers in Immunology Vol. 9 (2018) pp. 1696
ISSN: 1664-3224Online Full Text: dx.doi.org/ (Open Access) -
Conventional CD11chigh Dendritic Cells Are Important for T Cell Priming during the Initial Phase of Plasmodium yoelii Infection, but Are Dispensable at Later Time PointsIn: Frontiers in Immunology Vol. 8 (2017)
ISSN: 1664-3224Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
DC-Derived IL-10 Modulates Pro-inflammatory Cytokine Production and Promotes Induction of CD4+IL-10+ Regulatory T Cells during Plasmodium yoelii InfectionIn: Frontiers in Immunology Vol. 8 (2017)
ISSN: 1664-3224Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Sphingosine 1-Phosphate- and C-C Chemokine Receptor 2-Dependent Activation of CD4+ Plasmacytoid Dendritic Cells in the Bone Marrow Contributes to Signs of Sepsis-Induced ImmunosuppressionIn: Frontiers in Immunology Vol. 8 (2017)
ISSN: 1664-3224Online Full Text: dx.doi.org/ (Open Access) -
IL-10 downregulates CXCR3 expression on Th1 cells and interferes with their migration to intestinal inflammatory sitesIn: Mucosal Immunology Vol. 9 (2016) Nr. 5, pp. 1263 - 1277
ISSN: 1933-0219; 1935-3456Online Full Text: dx.doi.org/ (Open Access) -
Immune response modulation by Galectin-1 in a transgenic model of neuroblastomaIn: OncoImmunology Vol. 5 (2016) Nr. 5, pp. e1131378
ISSN: 2162-4011; 2162-402XOnline Full Text: dx.doi.org/ (Open Access) -
Breaking the co-operation between bystander T-cells and natural killer cells prevents the development of immunosuppression after traumatic skeletal muscle injury in miceIn: Clinical Science Vol. 128 (2015) Nr. 11, pp. 825 - 838
ISSN: 0143-5221Online Full Text: dx.doi.org/ (Open Access) -
Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancerIn: Cancer Research Vol. 74 (2014) Nr. 16, pp. 4258 - 4269
ISSN: 1538-7445; 0008-5472Online Full Text: dx.doi.org/ -
Neuropilin 1 guides regulatory T cells into VEGF-producing melanomaIn: OncoImmunology Vol. 2 (2013) Nr. 2, pp. e23039
ISSN: 2162-4011; 2162-402XOnline Full Text: dx.doi.org/ -
Correction: Inhibition of the transcription factor Foxp3 converts desmoglein 3-specific type 1 regulatory T cells into Th2-like cellsIn: The Journal of Immunology Vol. 189 (2012) Nr. 7, pp. 3779 - 3779
ISSN: 0022-1767; 1550-6606Online Full Text: dx.doi.org/ -
Local induction of immunosuppressive CD⁸ T cells in the gut-associated lymphoid tissuesIn: PLoS ONE Vol. 5 (2010) Nr. 10,
ISSN: 1932-6203Online Full Text: dx.doi.org/ (Open Access) -
Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrityIn: PLoS ONE Vol. 2 (2007) Nr. 12,
ISSN: 1932-6203Online Full Text: dx.doi.org/ (Open Access)