ZMB Member Winfried Siffert

ZMB Member
Winfried Siffert

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Winfried Siffert portrait
© UKE

Prof. Dr. Winfried Siffert

Group

Institute of Pharmacogenetics

University Hospital Essen
Hufelandstr. 55
45122 Essen

Research Overview

  • Genetics and pathophysiology of intracellular signal transduction,
  • Signal transduction and immune cell function,
  • Role of splice variants of heterotrimeric G proteins in different disorders,
  • Genetics of obesity and cardiovascular disorders (hypertension),
  • Genetic epidemiology.

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Selected Publications

    Journal articles

  • Möhlendick, Birte; Schmid, Kurt Werner; Siffert, Winfried
    The GNAS SNP c.393C>T (rs7121) as a marker for disease progression and survival in cancer
    In: Pharmacogenomics Vol. 20 (2019) Nr. 7, pp. 553 - 562
    Online Full Text: dx.doi.org/
  • Siffert, Winfried
    Institutional profile : institute of pharmacogenetics at the university hospital essen
    In: Pharmacogenomics Vol. 14 (2013) Nr. 3, pp. 241 - 243
    Online Full Text: dx.doi.org/
  • Klenke, Stefanie; Siffert, Winfried
    SNPs in genes encoding G proteins in pharmacogenetics
    In: Pharmacogenomics Vol. 12 (2011) Nr. 5, pp. 633 - 654
    Online Full Text: dx.doi.org/
  • Khandanpour, Cyrus; Thiede, Christian; Valk, Peter J.; Sharif-Askari, Ehssan; Nückel, Holger; Lohmann, Dietmar; Horsthemke, Bernhard; Siffert, Winfried; Neubauer, Andreas; Grzeschik, Karl-Heinz; Bloomfield, Clara D.; Marcucci, Guido; Maharry, Kati; Slovak, Marilyn L.; van der Reijden, Bert A.; Jansen, Joop H.; Schackert, Hans K.; Afshar, Khashayar; Schnittger, Susanne; Peeters, Justine K.; Kroschinsky, Frank; Ehninger, Gerhard; Lowenberg, Bob; Dührsen, Ulrich; Möröy, Tarik
    A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia
    In: Blood Vol. 115 (2010) Nr. 12, pp. 2462 - 2472
    Online Full Text: dx.doi.org/
  • Nückel, Holger; Frey, Ulrich; Bau, Maja; Sellmann, Ludger; Stanelle, Jens; Dürig, Jan; Jöckel, Karl-Heinz; Dührsen, Ulrich; Siffert, Winfried
    Association of a novel regulatory polymorphism (-938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia
    In: Blood Vol. 109 (2007) Nr. 1, pp. 290 - 297
    Online Full Text: dx.doi.org/
  • Nückel, Holger; Frey, Ulrich; Sellmann, Ludger; Bau, M.; Dürig, Jan; Dührsen, Ulrich; Siffert, Winfried
    Bax gene G(-248)A promoter polymorphism and chronic lymphocytic leukemia: lack of association with incidence, disease stage and progression-free survival
    In: Leukemia Vol. 20 (2006) Nr. 4, pp. 724
    Online Full Text: dx.doi.org/
  • Nückel, Holger; Frey, Ulrich; Dürig, Jan; Dührsen, Ulrich; Siffert, Winfried
    Methylenetetrahydrofolate reductase (MTHFR) gene 677C>T and 1298A>C polymorphisms are associated with differential apoptosis of leukemic B cells in vitro and disease progression in chronic lymphocytic leukemia
    In: Leukemia Vol. 18 (2004) Nr. 11, pp. 1816 - 1823
    Online Full Text: dx.doi.org/
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