ZMB Member Winfried Siffert

ZMB Member
Winfried Siffert

Next ZMB-Member
Winfried Siffert portrait
© UKE

Prof. Dr. Winfried Siffert

Group

Institute of Pharmacogenetics

University Hospital Essen
Hufelandstr. 55
45122 Essen

Research Overview

  • Genetics and pathophysiology of intracellular signal transduction,
  • Signal transduction and immune cell function,
  • Role of splice variants of heterotrimeric G proteins in different disorders,
  • Genetics of obesity and cardiovascular disorders (hypertension),
  • Genetic epidemiology.

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Selected Publications

    Journal articles

  • Möhlendick, Birte; Schmid, Kurt Werner; Siffert, Winfried
    The GNAS SNP c.393C>T (rs7121) as a marker for disease progression and survival in cancer
    In: Pharmacogenomics , Vol. 20 2019, Nr. 7, pp. 553 – 562
    DOI
  • Siffert, Winfried
    Institutional profile : institute of pharmacogenetics at the university hospital essen
    In: Pharmacogenomics , Vol. 14 2013, Nr. 3, pp. 241 – 243
    DOI
  • Klenke, Stefanie; Siffert, Winfried
    SNPs in genes encoding G proteins in pharmacogenetics
    In: Pharmacogenomics , Vol. 12 2011, Nr. 5, pp. 633 – 654
    DOI
  • Khandanpour, Cyrus; Thiede, Christian; Valk, Peter J.; Sharif-Askari, Ehssan; Nückel, Holger; Lohmann, Dietmar; Horsthemke, Bernhard; Siffert, Winfried; Neubauer, Andreas; Grzeschik, Karl-Heinz; Bloomfield, Clara D.; Marcucci, Guido; Maharry, Kati; Slovak, Marilyn L.; van der Reijden, Bert A.; Jansen, Joop H.; Schackert, Hans K.; Afshar, Khashayar; Schnittger, Susanne; Peeters, Justine K.; Kroschinsky, Frank; Ehninger, Gerhard; Lowenberg, Bob; Dührsen, Ulrich; Möröy, Tarik
    A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia
    In: Blood , Vol. 115 2010, Nr. 12, pp. 2462 – 2472
    DOI
  • Nückel, Holger; Frey, Ulrich; Bau, Maja; Sellmann, Ludger; Stanelle, Jens; Dürig, Jan; Jöckel, Karl-Heinz; Dührsen, Ulrich; Siffert, Winfried
    Association of a novel regulatory polymorphism (-938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia
    In: Blood , Vol. 109 2007, Nr. 1, pp. 290 – 297
    DOI
  • Nückel, Holger; Frey, Ulrich; Sellmann, Ludger; Bau, M.; Dürig, Jan; Dührsen, Ulrich; Siffert, Winfried
    Bax gene G(-248)A promoter polymorphism and chronic lymphocytic leukemia: lack of association with incidence, disease stage and progression-free survival
    In: Leukemia , Vol. 20 2006, Nr. 4, pp. 724
    DOI
  • Nückel, Holger; Frey, Ulrich; Dürig, Jan; Dührsen, Ulrich; Siffert, Winfried
    Methylenetetrahydrofolate reductase (MTHFR) gene 677C>T and 1298A>C polymorphisms are associated with differential apoptosis of leukemic B cells in vitro and disease progression in chronic lymphocytic leukemia
    In: Leukemia , Vol. 18 2004, Nr. 11, pp. 1816 – 1823
    DOI
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