ZMB Member Bernhard Singer

ZMB Member
Bernhard B. Singer

Next ZMB-Member
Bernhard B. Singer
© Anatomie/UKE/Singer

PD Dr. Bernhard B. Singer

Group

Institute of Anatomy

University Hospital Essen
Hufelandstr. 55
45147 Essen

Research Overview

The role of CEACAMs in infection, inflammation and wound healing

We characterize the CEACAM mediated cell-cell and cell-pathogene communication, signaling and function. Monoclonal antibodies, biactive glycoproteins, celllines and mouse models are generated as tools.
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Selected Publications

    Journal articles

  • van Sorge, Nina M.; Bonsor, Daniel A.; Deng, Liwen; Lindahl, Erik; Schmitt, Verena; Lyndin, Mykola; Schmidt, Alexej; Nilsson, Olof R.; Brizuela, Jaime; Boero, Elena; Sundberg, Eric J.; van Strijp, Jos A. G.; Doran, Kelly S.; Singer, Bernhard B.; Lindahl, Gunnar; McCarthy, Alex J.
    Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors
    In: The EMBO Journal Vol. 40 (2021) Nr. 7, pp. e106103
    ISSN: 0261-4189; 1460-2075
    Online Full Text: dx.doi.org/ (Open Access)
  • Helfrich, Iris; Singer, Bernhard B.
    Size Matters: The Functional Role of the CEACAM1 Isoform Signature and Its Impact for NK Cell-Mediated Killing in Melanoma
    In: Cancers Vol. 11 (2019) Nr. 3, pp. 356
    ISSN: 2072-6694
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Khairnar, Vishal; Duhan, Vikas; Patil, Ashwini M.; Zhou, Fan; Bhat, Hilal; Thoens, Christine; Sharma, Piyush; Adomati, Tom; Friendrich, Sarah-Kim; Bezgovsek, Judith; Dreesen, Janine D.; Wennemuth, Gunther; Westendorf, Astrid; Zelinskyy, Gennadiy; Dittmer, Ulf; Hardt, Cornelia; Timm, Jörg; Göthert, Joachim Rudolf; Lang, Philipp A.; Singer, Bernhard B.; Lang, Karl S.
    CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infection
    In: Nature Communications Vol. 9 (2018)
    ISSN: 2041-1723
    Online Full Text: dx.doi.org/ (Open Access)
  • Moonens, Kristof; Hamway, Youssef; Neddermann, Matthias; Reschke, Marc; Tegtmeyer, Nicole; Kruse, Tobias; Kammerer, Robert; Mejías-Luque, Raquel; Singer, Bernhard B.; Backert, Steffen; Gerhard, Markus; Remaut, Han
    Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs
    In: The EMBO Journal Vol. 37 (2018) Nr. 13,
    ISSN: 0261-4189; 1460-2075
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Javaheri, Anahita; Kruse, Tobias; Moonens, Kristof; Mejías-Luque, Raquel; Debraekeleer, Ayla; Asche, Carmen I.; Tegtmeyer, Nicole; Kalali, Behnam; Bach, Nina C.; Sieber, Stephan A.; Hill, Darryl J.; Königer, Verena; Hauck, Christof R.; Moskalenko, Roman; Haas, Rainer; Busch, Dirk H.; Klaile, Esther; Slevogt, Hortense; Schmidt, Alexej; Backert, Steffen; Remaut, Han; Singer, Bernhard B.; Gerhard, Markus
    Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs
    In: Nature Microbiology Vol. 2 (2017)
    ISSN: 2058-5276
    Online Full Text: dx.doi.org/ (Open Access)
  • Salehi, Sahar; Czugala, Marta; Stafiej, Piotr; Fathi, Mohammadhossein; Bahners, Thomas; Gutmann, Jochen Stefan; Singer, Bernhard B.; Fuchsluger, Thomas
    Poly (glycerol sebacate)-poly (ε-caprolactone) blend nanofibrous scaffold as intrinsic bio- and immunocompatible system for corneal repair
    In: Acta Biomaterialia Vol. 50 (2017) pp. 370 - 380
    ISSN: 1878-7568; 1742-7061
    Online Full Text: dx.doi.org/
  • Hu, Jun; Kovtun, Anna; Tomaszewski, Anke; Singer, Bernhard B.; Seitz, Berthold; Epple, Matthias; Steuhl, Klaus-Peter; Ergün, Süleyman; Fuchsluger, Thomas
    A new tool for the transfection of corneal endothelial cells : calcium phosphate nanoparticles
    In: Acta Biomaterialia Vol. 8 (2012) Nr. 3, pp. 1156 - 1163
    ISSN: 1878-7568; 1742-7061
    Online Full Text: dx.doi.org/
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