ZMB Member Bernhard Singer

ZMB Member
Bernhard B. Singer

Next ZMB-Member
Bernhard B. Singer
© Anatomie/UKE/Singer

PD Dr. Bernhard B. Singer

Group

Institute of Anatomy

University Hospital Essen
Hufelandstr. 55
45147 Essen

Research Overview

The role of CEACAMs in infection, inflammation and wound healing

We characterize the CEACAM mediated cell-cell and cell-pathogene communication, signaling and function. Monoclonal antibodies, biactive glycoproteins, celllines and mouse models are generated as tools.
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Selected Publications

    Journal articles

  • Catton, Erin A.; Bonsor, Daniel A.; Herrera, Carolina; Stålhammar-Carlemalm, Margaretha; Lyndin, Mykola; Turner, Claire E.; Soden, Jo; van Strijp, Jos A G; Singer, Bernhard B.; van Sorge, Nina M.; Lindahl, Gunnar; McCarthy, Alex J.
    Author Correction: Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis
    In: Nature Communications Vol. 14 (2023) Nr. 1, pp. 2675
    Online Full Text: dx.doi.org/ (Open Access)
  • Catton, Erin A.; Bonsor, Daniel A.; Herrera, Carolina; Stålhammar-Carlemalm, Margaretha; Lyndin, Mykola; Turner, Claire E.; Soden, Jo; van Strijp, Jos A.G .; Singer, Bernhard B.; van Sorge, Nina M.; Lindahl, Gunnar; McCarthy, Alex J.
    Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis
    In: Nature Communications Vol. 14 (2023) Nr. 1, 2275
    Online Full Text: dx.doi.org/ (Open Access)
  • van Sorge, Nina M.; Bonsor, Daniel A.; Deng, Liwen; Lindahl, Erik; Schmitt, Verena; Lyndin, Mykola; Schmidt, Alexej; Nilsson, Olof R.; Brizuela, Jaime; Boero, Elena; Sundberg, Eric J.; van Strijp, Jos A. G.; Doran, Kelly S.; Singer, Bernhard B.; Lindahl, Gunnar; McCarthy, Alex J.
    Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors
    In: The EMBO Journal Vol. 40 (2021) Nr. 7, pp. e106103
    Online Full Text: dx.doi.org/ (Open Access)
  • Helfrich, Iris; Singer, Bernhard B.
    Size Matters: The Functional Role of the CEACAM1 Isoform Signature and Its Impact for NK Cell-Mediated Killing in Melanoma
    In: Cancers Vol. 11 (2019) Nr. 3, pp. 356
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Khairnar, Vishal; Duhan, Vikas; Patil, Ashwini M.; Zhou, Fan; Bhat, Hilal; Thoens, Christine; Sharma, Piyush; Adomati, Tom; Friendrich, Sarah-Kim; Bezgovsek, Judith; Dreesen, Janine D.; Wennemuth, Gunther; Westendorf, Astrid; Zelinskyy, Gennadiy; Dittmer, Ulf; Hardt, Cornelia; Timm, Jörg; Göthert, Joachim Rudolf; Lang, Philipp A.; Singer, Bernhard B.; Lang, Karl S.
    CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infection
    In: Nature Communications Vol. 9 (2018) 2561
    Online Full Text: dx.doi.org/ (Open Access)
  • Horst, Andrea Kristina; Wegscheid, Claudia; Schaefers, Christoph; Schiller, Birgit; Neumann, Katrin; Lunemann, Sebastian; Langeneckert, Annika E; Oldhafer, Karl J; Weiler-Normann, Christina; Lang, Karl S.; Singer, Bernhard B.; Altfeld, Marcus; Diehl, Linda; Tiegs, Gisa
    Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice
    In: Hepatology Vol. 68 (2018) Nr. 1, pp. 200 - 214
    Online Full Text: dx.doi.org/
  • Moonens, Kristof; Hamway, Youssef; Neddermann, Matthias; Reschke, Marc; Tegtmeyer, Nicole; Kruse, Tobias; Kammerer, Robert; Mejías-Luque, Raquel; Singer, Bernhard B.; Backert, Steffen; Gerhard, Markus; Remaut, Han
    Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs
    In: The EMBO Journal Vol. 37 (2018) Nr. 13,
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Javaheri, Anahita; Kruse, Tobias; Moonens, Kristof; Mejías-Luque, Raquel; Debraekeleer, Ayla; Asche, Carmen I.; Tegtmeyer, Nicole; Kalali, Behnam; Bach, Nina C.; Sieber, Stephan A.; Hill, Darryl J.; Königer, Verena; Hauck, Christof R.; Moskalenko, Roman; Haas, Rainer; Busch, Dirk H.; Klaile, Esther; Slevogt, Hortense; Schmidt, Alexej; Backert, Steffen; Remaut, Han; Singer, Bernhard B.; Gerhard, Markus
    Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs
    In: Nature Microbiology Vol. 2 (2017) 16189
    Online Full Text: dx.doi.org/ (Open Access)
  • Salehi, Sahar; Czugala, Marta; Stafiej, Piotr; Fathi, Mohammadhossein; Bahners, Thomas; Gutmann, Jochen Stefan; Singer, Bernhard B.; Fuchsluger, Thomas
    Poly (glycerol sebacate)-poly (ε-caprolactone) blend nanofibrous scaffold as intrinsic bio- and immunocompatible system for corneal repair
    In: Acta Biomaterialia Vol. 50 (2017) pp. 370 - 380
    Online Full Text: dx.doi.org/
  • Hu, Jun; Kovtun, Anna; Tomaszewski, Anke; Singer, Bernhard B.; Seitz, Berthold; Epple, Matthias; Steuhl, Klaus-Peter; Ergün, Süleyman; Fuchsluger, Thomas
    A new tool for the transfection of corneal endothelial cells : calcium phosphate nanoparticles
    In: Acta Biomaterialia Vol. 8 (2012) Nr. 3, pp. 1156 - 1163
    Online Full Text: dx.doi.org/
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