ZMB Member Jens Siveke
ZMB Member
Jens Siveke
Next ZMB-Member
Prof. Dr. Jens Siveke
West German Cancer Center (WTZ)
and
Division for Solid Tumor Translational Oncology
DKTK/DKFZ partner site Essen
Medical Faculty
University Duisburg-Essen
45141 Essen
- +49 201 723 3704
- Website
- Selected Publications
- Publication Metrics
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- ZMB Research Program
Oncology
Research Overview
- Pancreatic Cancer and hard to treat cancers (eg NUT midline carcinoma, uveal melanoma)
- Preclinical Model Systems (organoids, PDX, GEMM)
- Tumor phenotypes (Tumor Heterogeneity, Cellular Plasticity, (epi)genomic alterations)
- Tumor Microenvironment and Immunooncology
- Drug Discovery
- Moleacular Imaging and Imaging-guided Therapy (Theranostics)
- Liquid Biopsy
Selected Publications
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Pazopanib with 5-FU and oxaliplatin as first line therapy in advanced gastric cancer : A randomized phase-II study - The PaFLO trial. A study of the Arbeitsgemeinschaft Internistische Onkologie AIO-STO-0510In: International Journal of Cancer Vol. 150 (2022) Nr. 6, pp. 1007 - 1017
ISSN: 0020-7136; 1097-0215Online Full Text: dx.doi.org/ (Open Access) -
Nab-paclitaxel plus gemcitabine versus nab-paclitaxel plus gemcitabine followed by FOLFIRINOX induction chemotherapy in locally advanced pancreatic cancer (NEOLAP-AIO-PAK-0113) : a multicentre, randomised, phase 2 trialIn: The Lancet Gastroenterology & Hepatology Vol. 6 (2021) Nr. 2, pp. 128 - 138
ISSN: 2468-1253Online Full Text: dx.doi.org/ -
Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinomaIn: International Journal of Cancer Vol. 147 (2020) Nr. 10, pp. 2847 - 2861
ISSN: 0020-7136; 1097-0215Online Full Text: dx.doi.org/ (Open Access) -
Implementing cell-free DNA of pancreatic cancer patient–derived organoids for personalized oncologyIn: JCI Insight Vol. 5 (2020) Nr. 15, pp. e137809
ISSN: 2379-3708Online Full Text: dx.doi.org/ (Open Access) -
Loss of Wasl improves pancreatic cancer outcomeIn: JCI Insight Vol. 5 (2020) Nr. 10,
ISSN: 2379-3708Online Full Text: dx.doi.org/ (Open Access) -
Phase III randomized, double-blind study of paclitaxel with and without everolimus in patients with advanced gastric or esophagogastric junction carcinoma who have progressed after therapy with a fluoropyrimidine/platinum-containing regimen (RADPAC)In: International Journal of Cancer Vol. 147 (2020) Nr. 9, pp. 2493 - 2502
ISSN: 0020-7136; 1097-0215Online Full Text: dx.doi.org/ (Open Access) -
Serial Circulating Tumor DNA Mutational Status in Patients with KRAS-Mutant Metastatic Colorectal Cancer from the Phase 3 AIO KRK0207 TrialIn: Clinical Chemistry Vol. 66 (2020) Nr. 12, pp. 1510 - 1520
ISSN: 0009-9147; 1530-8561Online Full Text: dx.doi.org/ (Open Access) -
The transcription factor FLI1 promotes cancer progression by affecting cell cycle regulationIn: International Journal of Cancer Vol. 147 (2020) Nr. 1, pp. 189 - 201
ISSN: 0020-7136; 1097-0215Online Full Text: dx.doi.org/ (Open Access) -
Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinomaIn: Oncogene Vol. 39 (2020) Nr. 24, pp. 4770 - 4779
ISSN: 1476-5594; 0950-9232Online Full Text: dx.doi.org/ (Open Access) -
Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal CancerIn: Cancer Research Vol. 79 (2019) Nr. 9, pp. 2367 - 2378
ISSN: 0008-5472; 1538-7445; 0099-7013; 0099-7374Online Full Text: dx.doi.org/ (Open Access) -
Consensus statement on mandatory measurements in pancreatic cancer trials (COMM-PACT) for systemic treatment of unresectable diseaseIn: The Lancet Oncology Vol. 19 (2018) Nr. 3, pp. e151 - e160
ISSN: 1470-2045; 1474-5488Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Notch-induced myeloid reprogramming in spontaneous pancreatic ductal adenocarcinoma by dual genetic targetingIn: Cancer Research Vol. 78 (2018) Nr. 17, pp. 4997 - 5010
ISSN: 0008-5472; 1538-7445Online Full Text: dx.doi.org/ (Open Access) -
Co-clinical assessment of tumor cellularity in pancreatic cancerIn: Clinical Cancer Research Vol. 23 (2017) Nr. 6, pp. 1461 - 1470
ISSN: 1557-3265; 1078-0432Online Full Text: dx.doi.org/ -
Kras(G12D) induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cellsIn: Oncogene Vol. 35 (2016) Nr. 29, pp. 3880 - 3886
ISSN: 0950-9232; 1476-5594Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
EGF Receptor Is Required for KRAS-Induced Pancreatic TumorigenesisIn: Cancer Cell Vol. 22 (2012) Nr. 3, pp. 304 - 317
ISSN: 1535-6108; 1878-3686Online Full Text: dx.doi.org/ (Open Access) -
Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinomaIn: Proceedings of the National Academy of Sciences of the United States of America Vol. 107 (2010) Nr. 30, pp. 13438 - 13443
ISSN: 1091-6490; 0027-8424Online Full Text: dx.doi.org/ (Open Access)