ZMB Member Jens Siveke

ZMB Member
Jens Siveke

Next ZMB-Member
Jens Siveke
© UKE

Prof. Dr. Jens Siveke

Group

Bridge Institute for Experimental Tumor Therapy

West German Cancer Center (WTZ)
and
Division for Solid Tumor Translational Oncology
DKTK/DKFZ partner site Essen

Medical Faculty
University Duisburg-Essen
45141 Essen

Research Overview

  • Pancreatic Cancer and hard to treat cancers (eg NUT midline carcinoma, uveal melanoma)
  • Preclinical Model Systems (organoids, PDX, GEMM)
  • Tumor phenotypes (Tumor Heterogeneity, Cellular Plasticity, (epi)genomic alterations)
  • Tumor Microenvironment and Immunooncology
  • Drug Discovery
  • Moleacular Imaging and Imaging-guided Therapy (Theranostics)
  • Liquid Biopsy

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Selected Publications

    Journal articles

  • Kebir, Sied; Ullrich, Vivien; Berger, Pia; Dobersalske, Celia; Langer, Sarah; Rauschenbach, Laurèl; Trageser, Daniel; Till, Andreas; Lorbeer, Franziska K.; Wieland, Anja; Wilhelm-Buchstab, Timo; Ahmad, Ashar; Fröhlich, Holger; Cima, Igor; Prasad, Shruthi; Matschke, Johann; Jendrossek, Verena; Remke, Marc; Grüner, Barbara M.; Rösch, Alexander; Siveke, Jens; Herold-Mende, Christel; Blau, Tobias; Keyvani, Kathy; van Landeghem, Frank K H; Pietsch, Torsten; Felsberg, Jörg; Reifenberger, Guido; Weller, Michael; Sure, Ulrich; Brüstle, Oliver; Simon, Matthias; Glas, Martin; Scheffler, Björn
    A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma
    In: Clinical Cancer Research Vol. 29 (2023) Nr. 2, pp. 488 - 500
    Online Full Text: dx.doi.org/ (Open Access)
  • Erice, Oihane; Narayanan, Shruthi; Feliu, Iker; Entrialgo-Cadierno, Rodrigo; Malinova, Antonia; Vicentini, Caterina; Guruceaga, Elizabeth; Delfino, Pietro; Trajkovic-Arsic, Marija; Moreno, Haritz; Valencia, Karmele; Blanco, Ester; Macaya, Irati; Öhlund, Daniel; Khatri, Purvesh; Lecanda, Fernando; Scarpa, Aldo; Siveke, Jens T.; Corbo, Vincenzo; Ponz-Sarvise, Mariano; Vicent, Silve
    LAMC2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer Growth
    In: Clinical Cancer Research Vol. 29 (2023) Nr. 6, pp. 1137 - 1154
    Online Full Text: dx.doi.org/
  • Högner, Anica; Al-Batran, Salah-Eddin; Siveke, Jens; Lorenz, Mario; Bartels, Prisca; Breithaupt, Kirstin; Malfertheiner, Peter; Homann, Nils; Stein, Alexander; Gläser, Dietrich; Tamm, Ingo; Hinke, Axel; Vogel, Arndt; Thuss-Patience, Peter
    Pazopanib with 5-FU and oxaliplatin as first line therapy in advanced gastric cancer : A randomized phase-II study - The PaFLO trial. A study of the Arbeitsgemeinschaft Internistische Onkologie AIO-STO-0510
    In: International Journal of Cancer Vol. 150 (2022) Nr. 6, pp. 1007 - 1017
    Online Full Text: dx.doi.org/ (Open Access)
  • Fendler, Wolfgang; Pabst, Kim M.; Kessler, Lukas; Fragoso Costa, Pedro; Ferdinandus, Justin; Weber, Manuel; Lippert, Maria; Lückerath, Katharina; Umutlu, Lale; Kostbade, Karina; Mavroeidi, Ilektra A.; Schuler, Martin; Ahrens, Marit; Rischpler, Christoph; Bauer, Sebastian; Herrmann, Ken; Siveke, Jens; Hamacher, Rainer
    Safety and Efficacy of 90Y-FAPI-46 Radioligand Therapy in Patients with Advanced Sarcoma and Other Cancer Entities
    In: Clinical Cancer Research Vol. 28 (2022) Nr. 19, pp. 4346 - 4353
    Online Full Text: dx.doi.org/ (Open Access)
  • Kunzmann, Volker; Siveke, Jens; Algül, Hana; Goekkurt, Eray; Siegler, Gabriele; Martens, Uwe; Waldschmidt, Dirk; Pelzer, Uwe; Fuchs, Martin; Kullmann, Frank; Boeck, Stefan; Ettrich, Thomas J; Held, Swantje; Keller, Ralph; Klein, Ingo; Germer, Christoph-Thomas; Stein, Hubert; Friess, Helmut; Bahra, Marcus; Jakobs, Ralf; Hartlapp, Ingo; Heinemann, Volker; German Pancreatic Cancer Working Group (AIO-PAK) and NEOLAP investigators; Stahl, Michael; Mahlmann, Stefan
    Nab-paclitaxel plus gemcitabine versus nab-paclitaxel plus gemcitabine followed by FOLFIRINOX induction chemotherapy in locally advanced pancreatic cancer (NEOLAP-AIO-PAK-0113) : a multicentre, randomised, phase 2 trial
    In: The Lancet Gastroenterology & Hepatology Vol. 6 (2021) Nr. 2, pp. 128 - 138
    Online Full Text: dx.doi.org/
  • Zhang, Xin; Zegar, Tim; Weiser, Tim; Hamdan, Feda H.; Berger, Benedict-Tilman; Lucas, Romain; Balourdas, Dimitrios-IIias; Ladigan, Swetlana; Cheung, Phyllis F.; Liffers, Sven-Thorsten; Trajkovic-Arsic, Marija; Scheffler, Björn; Joerger, Andreas C.; Hahn, Stephan A.; Johnsen, Steven A.; Knapp, Stefan; Siveke, Jens
    Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma
    In: International Journal of Cancer Vol. 147 (2020) Nr. 10, pp. 2847 - 2861
    Online Full Text: dx.doi.org/ (Open Access)
  • Dantes, Zahra; Yen, Hsi-Yu; Pfarr, Nicole; Winter, Christof; Steiger, Katja; Muckenhuber, Alexander; Hennig, Alexander; Lange, Sebastian; Engleitner, Thomas; Öllinger, Rupert; Maresch, Roman; Orben, Felix; Heid, Irina; Kaissis, Georgios; Shi, Kuangyu; Topping, Geoffrey; Stögbauer, Fabian; Wirth, Matthias; Peschke, Katja; Papargyriou, Aristeidis; Rezaee-Oghazi, Massoud; Feldmann, Karin; Schäfer, Arlett P.G.; Ranjan, Raphela; Lubeseder-Martellato, Clara; Stange, Daniel E.; Welsch, Thilo; Martignoni, Marc; Ceyhan, Güralp O.; Friess, Helmut; Herner, Alexander; Liotta, Lucia; Treiber, Matthias; von Figura, Guido; Abdelhafez, Mohamed; Klare, Peter; Schlag, Christoph; Algül, Hana; Siveke, Jens; Braren, Rickmer; Weirich, Gregor; Weichert, Wilko; Saur, Dieter; Rad, Roland; Schmid, Roland M.; Schneider, Günter; Reichert, Maximilian
    Implementing cell-free DNA of pancreatic cancer patient–derived organoids for personalized oncology
    In: JCI Insight Vol. 5 (2020) Nr. 15, pp. e137809
    Online Full Text: dx.doi.org/ (Open Access)
  • Hidalgo-Sastre, Ana; Desztics, Judit; Dantes, Zahra; Schulte, Katharina; Ensarioglu, Hilal Kabadayi; Bassey-Archibong, Blessing; Öllinger, Rupert; Engleiter, Thomas; Rayner, Lyndsay; Einwächter, Henrik; Daniel, Juliet M.; Altaee, Ali Sameer Abdulghani; Steiger, Katia; Lesina, Marina; Rad, Roland; Reichert, Maximilian; Von Figura, Guido; Siveke, Jens; Schmid, Roland M.; Lubeseder-Martellato, Clara
    Loss of Wasl improves pancreatic cancer outcome
    In: JCI Insight Vol. 5 (2020) Nr. 10, e127275
    Online Full Text: dx.doi.org/ (Open Access)
  • Lorenzen, Sylvie; Knorrenschild, Jorge Riera; Pauligk, Claudia; Hegewisch-Becker, Susanna; Seraphin, Jörg; Thuss-Patience, Peter; Kopp, Hans-Georg; Dechow, Tobias; Vogel, Arndt; Luley, Kim Barbara; Pink, Daniel; Stahl, Michael; Kullmann, Frank; Hebart, Holger; Siveke, Jens; Egger, Matthias; Homann, Nils; Probst, Stephan; Goetze, Thorsten Oliver; Al-Batran, Salah-Eddin
    Phase III randomized, double-blind study of paclitaxel with and without everolimus in patients with advanced gastric or esophagogastric junction carcinoma who have progressed after therapy with a fluoropyrimidine/platinum-containing regimen (RADPAC)
    In: International Journal of Cancer Vol. 147 (2020) Nr. 9, pp. 2493 - 2502
    Online Full Text: dx.doi.org/ (Open Access)
  • Lueong, Smiths S; Herbst, Andreas; Liffers, Sven-Thorsten; Bielefeld, Nicola; Horn, Peter; Tannapfel, Andrea; Reinacher-Schick, Anke; Hinke, Axel; Hegewisch-Becker, Susanna; Kolligs, Frank T; Siveke, Jens
    Serial Circulating Tumor DNA Mutational Status in Patients with KRAS-Mutant Metastatic Colorectal Cancer from the Phase 3 AIO KRK0207 Trial
    In: Clinical Chemistry Vol. 66 (2020) Nr. 12, pp. 1510 - 1520
    Online Full Text: dx.doi.org/ (Open Access)
  • Miao, Beiping; Bauer, Andrea S.; Hufnagel, Katrin; Wu, Yenan; Trajkovic-Arsic, Marija; Pirona, Anna C.; Giese, Nathalia; Taipale, Jussi; Siveke, Jens; Hoheisel, Jörg D.; Lueong, Smiths
    The transcription factor FLI1 promotes cancer progression by affecting cell cycle regulation
    In: International Journal of Cancer Vol. 147 (2020) Nr. 1, pp. 189 - 201
    Online Full Text: dx.doi.org/ (Open Access)
  • Zhang, Xin; Zegar, Tim; Lucas, Anais; Morrison-Smith, Chevaun; Knox, Tatiana; French, Christopher A.; Knapp, Stefan; Müller, Susanne; Siveke, Jens
    Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma
    In: Oncogene Vol. 39 (2020) Nr. 24, pp. 4770 - 4779
    Online Full Text: dx.doi.org/ (Open Access)
  • Weisner, Jörn; Landel, Ina; Reintjes, Christoph; Uhlenbrock, Niklas; Trajkovic-Arsic, Marija; Dienstbier, Niklas; Hardick, Julia; Ladigan, Swetlana; Lindemann, Marius; Smith, Steven; Quambusch, Lena; Scheinpflug, Rebekka; Depta, Laura; Gontla, Rajesh; Unger, Anke; Müller, Heiko; Baumann, Matthias; Schultz-Fademrecht, Carsten; Gunther, Georgia; Maghnouj, Abdelouahid; Müller, Matthias P.; Pohl, Michael; Teschendorf, Christian; Wolters, Heiner; Viebahn, Richard; Tannapfel, Andrea; Uhl, Waldemar; Hengstler, Jan G.; Hahn, Stephan A.; Siveke, Jens; Rauh, Daniel
    Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer
    In: Cancer Research Vol. 79 (2019) Nr. 9, pp. 2367 - 2378
    Online Full Text: dx.doi.org/
  • ter Veer, Emil; van Rijssen, L. Bengt; Besselink, Marc G.; Mali, Rosa M. A.; Berlin, Jordan D.; Boeck, Stefan; Bonnetain, Franck; Chau, Ian; Conroy, Thierry; Van Cutsem, Eric; Deplanque, Gael; Friess, Helmut; Glimelius, Bengt; Goldstein, David; Herrmann, Richard; Labianca, Roberto; Van Laethem, Jean-Luc; Macarulla, Teresa; van der Meer, Jonathan H. M.; Neoptolemos, John P.; Okusaka, Takuji; O'Reilly, Eileen M.; Pelzer, Uwe; Philip, Philip A.; van der Poel, Marcel J.; Reni, Michele; Scheithauer, Werner; Siveke, Jens; Verslype, Chris; Busch, Olivier R.; Wilmink, Johanna W.; van Oijen, Martijn G. H.; van Laarhoven, Hanneke W. M.
    Consensus statement on mandatory measurements in pancreatic cancer trials (COMM-PACT) for systemic treatment of unresectable disease
    In: The Lancet Oncology Vol. 19 (2018) Nr. 3, pp. e151 - e160
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Cheung, Phyllis F.; Neff, Florian; Neander, Christian; Bazarna, Anna; Savvatakis, Konstantinos; Liffers, Sven-Thorsten; Althoff, Kristina; Lee, Chang-Lung; Moding, Everett J.; Kirsch, David G.; Saur, Dieter; Bazhin, Alexandr V.; Trajkovic-Arsic, Marija; Heikenwalder, Mathias F.; Siveke, Jens
    Notch-induced myeloid reprogramming in spontaneous pancreatic ductal adenocarcinoma by dual genetic targeting
    In: Cancer Research Vol. 78 (2018) Nr. 17, pp. 4997 - 5010
    Online Full Text: dx.doi.org/ (Open Access)
  • Heid, Irina; Steiger, Katja; Trajkovic-Arsic, Marija; Settles, Marcus; Eßwein, Manuela R.; Erkan, Mert; Kleeff, Jörg; Jäger, Carsten; Friess, Helmut; Haller, Bernhard; Steingötter, Andreas; Schmid, Roland M.; Schwaiger, Markus; Rummeny, Ernst J.; Esposito, Irene; Siveke, Jens; Braren, Rickmer F.
    Co-clinical assessment of tumor cellularity in pancreatic cancer
    In: Clinical Cancer Research Vol. 23 (2017) Nr. 6, pp. 1461 - 1470
    Online Full Text: dx.doi.org/
  • Diersch, S; Wirth, M; Schneeweis, C; Jörs, S; Geisler, F; Siveke, Jens; Rad, R; Schmid, R M; Saur, D; Rustgi, A K; Reichert, M; Schneider, G
    Kras(G12D) induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells
    In: Oncogene Vol. 35 (2016) Nr. 29, pp. 3880 - 3886
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Ardito, Christine M.; Grüner, Barbara M.; Takeuchi, Kenneth K.; Lubeseder-Martellato, Clara; Teichmann, Nicole; Mazur, Pawel K.; DelGiorno, Kathleen E.; Carpenter, Eileen S.; Halbrook, Christopher J.; Hall, Jason C.; Pal, Debjani; Briel, Thomas; Herner, Alexander; Trajkovic-Arsic, Marija; Sipos, Bence; Liou, Geou-Yarh; Storz, Peter; Murray, Nicole R.; Threadgill, David W.; Sibilia, Maria; Washington, M. Kay; Wilson, Carole L.; Schmid, Roland M.; Raines, Elaine W.; Crawford, Howard C.; Siveke, Jens
    EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis
    In: Cancer Cell Vol. 22 (2012) Nr. 3, pp. 304 - 317
    Online Full Text: dx.doi.org/ (Open Access)
  • Mazur, Pawel K.; Einwächter, Henrik; Lee, Marcel; Sipos, Bence; Nakhai, Hassan; Rad, Roland; Zimber-Strobl, Ursula; Strobl, Lothar J.; Radtke, Freddy; Klöppel, Günter; Schmid, Roland M.; Siveke, Jens
    Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma
    In: Proceedings of the National Academy of Sciences of the United States of America Vol. 107 (2010) Nr. 30, pp. 13438 - 13443
    Online Full Text: dx.doi.org/ (Open Access)
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