ZMB Member Kathrin Sutter

ZMB Member
Kathrin Sutter

Next Member
Kathrin Sutter

PD Dr. Kathrin Sutter

TRR60 Junior Research Group

Interferon-alpha Subtypes in chronic viral infections

Institute of Virology
University Hospital Essen
Hufelandstr. 55
45147 Essen

Research Overview

  • Interferon-alpha subtypes
  • Modulation of immune cells
  • Immunotherapies
  • Chronic viral infections (HIV, HBV)
  • IFN-stimulated genes
  • NK cells
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Publications

    Journal articles

  • Liu, Jia; Yang, Xuecheng; Wang, Hua; Li, Ziwei; Deng, Hui; Liu, Jing; Xiong, Shue; He, Junyi; Feng, Xuemei; Guo, Chunxia; Wang, Weixian; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Senff, Tina; Menne, Christopher; Timm, Jörg; Zhang, Yanfang; Deng, Fei; Lu, Yinping; Wu, Jun; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Wang, Baoju; Zheng, Xin
    Analysis of the long-term impact on cellular immunity in COVID-19-recovered individuals reveals a profound nkt cell impairment
    In: mBio Vol. 12 (2021) Nr. 2, pp. e00085 - 21
    ISSN: 2150-7511; 2161-2129
    Online Full Text: dx.doi.org/ (Open Access)
  • Chen, Jieliang; Li, Yaming; Lai, Fritz; Wang, Yang; Sutter, Kathrin; Dittmer, Ulf; Ye, Jianyu; Zai, Wenjing; Liu, Min; Shen, Fang; Wu, Min; Hu, Kongying; Li, Baocun; Lu, Mengji; Zhang, Xiaonan; Zhang, Jiming; Li, Jianhua; Chen, Qingfeng; Yuan, Zhenghong
    Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ Signaling
    In: Hepatology Vol. 73 (2021) Nr. 2, pp. 486 - 502
    ISSN: 1527-3350; 0270-9139
    Online Full Text: dx.doi.org/
  • Wang, Shichuan; Trilling, Mirko; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Zheng, Xin; Yang, Dongliang; Liu, Jia
    A Crowned Killer’s Résumé : Genome, Structure, Receptors, and Origin of SARS-CoV-2
    In: Virologica Sinica (2020)
    ISSN: 1995-820X; 1674-0769
    Online Full Text: dx.doi.org/
  • Sutter, Kathrin
    Die Einmischer: Interferone : Wie sie die Immunantwort beeinflussen, um Viren effektiv zu bekämpfen
    In: Unikate: Berichte aus Forschung und Lehre (2020) Nr. 54: Medizin: Infektionskrankheiten - ein globales Problem, pp. 18 - 27
    ISSN: 0941-746X
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Erratum for Westmeier et al., "Impaired Cytotoxic CD8⁺ T Cell Response in Elderly COVID-19 Patients"
    In: mBio Vol. 11 (2020) Nr. 5, pp. 02243 - 02220
    ISSN: 2150-7511
    Online Full Text: dx.doi.org/ (Open Access)
  • Ickler, Julia; Francois, Sandra; Widera, Marek; Santiago, Mario L.; Dittmer, Ulf; Sutter, Kathrin
    HIV infection does not alter interferon α/β receptor 2 expression on mucosal immune cells
    In: PLoS ONE Vol. 15 (2020) Nr. 1, pp. e0218905
    ISSN: 1932-6203
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Impaired cytotoxic CD8⁺ T cell response in elderly COVID-19 patients
    In: mBio Vol. 11 (2020) Nr. 5, pp. e02243 - 20
    ISSN: 2150-7511; 2161-2129
    Online Full Text: dx.doi.org/ (Open Access)
  • Liu, Jia; Zheng, Xin; Tong, Qiaoxia; Li, Wei; Wang, Baoju; Sutter, Kathrin; Trilling, Mirko; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang
    Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV
    In: Journal of Medical Virology Vol. 92 (2020) Nr. 5, pp. 491 - 494
    ISSN: 1096-9071; 0146-6615
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Guo, Kejun; Shen, Guannan; Kibbie, Jon; Gonzalez, Tania; Dillon, Stephanie M.; Smith, Harry A.; Cooper, Emily H.; Lavender, Kerry; Hasenkrug, Kim J.; Sutter, Kathrin; Dittmer, Ulf; Kroehl, Miranda; Kechris, Katerina; Wilson, Cara C.; Santiago, Mario L.
    Qualitative differences between the IFNα subtypes and IFNβ influence chronic mucosal HIV-1 pathogenesis
    In: PLoS Pathogens Vol. 16 (2020) Nr. 10, pp. 1008986
    ISSN: 1553-7374; 1553-7366
    Online Full Text: dx.doi.org/ (Open Access)
  • Zutz, Ariane; Schölz, Christian; Schneider, Stephanie; Pierini, Virginia; Münchhoff, Maximilian; Sutter, Kathrin; Wittmann, Georg; Dittmer, Ulf; Draenert, Rika; Bogner, Johannes R.; Fackler, Oliver T.; Keppler, Oliver T.
    SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation
    In: Journal of Innate Immunity Vol. 12 (2020) Nr. 5, pp. 399 - 409
    ISSN: 1662-8128; 1662-811X
    Online Full Text: dx.doi.org/ (Open Access)
  • Heilingloh, Christiane Silke; Aufderhorst, Ulrich Wilhelm; Schipper, Leonie; Dittmer, Ulf; Witzke, Oliver; Yang, Dongliang; Zheng, Xin; Sutter, Kathrin; Trilling, Mirko; Alt, Mira; Steinmann, Eike; Krawczyk, Adalbert
    Susceptibility of SARS-CoV-2 to UV irradiation
    In: American Journal of Infection Control Vol. 48 (2020) Nr. 10, pp. 1273 - 1275
    ISSN: 1527-3296; 0196-6553
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Matos, Aline da Rocha; Wunderlich, Katharina; Schloer, Sebastian; Schughart, Klaus; Geffers, Robert; Seders, Martine; Witt, Marlous de; Christersson, Anmari; Wiewrodt, Rainer; Wiebe, Karsten; Barth, Peter; Hocke, Andreas; Hippenstiel, Stefan; Hönzke, Katja; Dittmer, Ulf; Sutter, Kathrin; Rescher, Ursula; Rodionycheva, Svetlana; Matera, Nicoletta; Ludwig, Stephan; Brunotte, Linda
    Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities
    In: Emerging Microbes & Infections Vol. 8 (2019) Nr. 1, pp. 1763 - 1776
    ISSN: 2222-1751
    Online Full Text: dx.doi.org/ (Open Access)
  • Passos, Vânia; Zillinger, Thomas; Casartelli, Nicoletta; Wachs, Amelie S.; Xu, Shuting; Malassa, Angelina; Steppich, Katja; Schilling, Hildegard; Franz, Sergej; Todt, Daniel; Steinmann, Eike; Sutter, Kathrin; Dittmer, Ulf; Bohne, Jens; Schwartz, Olivier; Barchet, Winfried; Goffinet, Christine
    Characterization of Endogenous SERINC5 Protein as Anti-HIV-1 Factor
    In: Journal of Virology Vol. 93 (2019) Nr. 24, pp. e01221 - 19
    ISSN: 1098-5514; 0022-538X
    Online Full Text: dx.doi.org/ (Open Access)
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Sutter, Kathrin; Ross, Jean Alexander; Paschen, Annette; Windmann, Sonja; Schimmer, Simone; Dittmer, Ulf
    Chronic retroviral infection of mice promotes tumor development, but CD137 agonist therapy restores effective tumor immune surveillance
    In: Cancer Immunology, Immunotherapy Vol. 68 (2019) Nr. 3, pp. 479 - 488
    ISSN: 1432-0851; 0340-7004
    Online Full Text: dx.doi.org/
  • Sutter, Kathrin; Lavender, Kerry J.; Messer, Ronald J.; Widera, Marek; Williams, Katie; Race, Brent; Hasenkrug, Kim J.; Dittmer, Ulf
    Concurrent administration of IFNα14 and cART in TKO-BLT mice enhances suppression of HIV-1 viremia but does not eliminate the latent reservoir
    In: Scientific Reports Vol. 9 (2019) pp. 18089
    ISSN: 2045-2322
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Hasenkrug, Kim J.; Lavender, Kerry J.; Santiago, Mario L.; Sutter, Kathrin; Dittmer, Ulf
    Different Biological Activities of Specific Interferon Alpha Subtypes
    In: mSphere Vol. 4 (2019) Nr. 4, pp. e00127 - 19
    ISSN: 2379-5042
    Online Full Text: dx.doi.org/ (Open Access)
  • Dickow, Julia; Francois, Sandra; Kaiserling, Rouven-Luca; Malyshkina, Anna; Drexler, Ingo; Westendorf, Astrid Maria; Lang, Karl Sebastian; Santiago, Mario L.; Dittmer, Ulf; Sutter, Kathrin
    Diverse immunomodulatory effects of individual IFNα subtypes on virus-specific CD8⁺ T cell responses
    In: Frontiers in Immunology Vol. 10 (2019) pp. 2255
    ISSN: 1664-3224
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Dittmer, Ulf; Sutter, Kathrin; Kassiotis, George; Zelinskyy, Gennadiy; Bánki, Zoltán; Stoiber, Heribert; Santiago, Mario L.; Hasenkrug, Kim J.
    Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity
    In: FEMS Microbiology Reviews Vol. 43 (2019) Nr. 5, pp. 435 - 456
    ISSN: 1574-6976; 0168-6445
    Online Full Text: dx.doi.org/
  • Braun, Elisabeth; Hotter, Dominik; Koepke, Lennart; Zech, Fabian; Groß, Rüdiger; Sparrer, Konstantin M.J.; Müller, Janis A.; Pfaller, Christian K.; Heusinger, Elena; Wombacher, Rebecka; Sutter, Kathrin; Dittmer, Ulf; Winkler, Michael; Simmons, Graham; Jakobsen, Martin R.; Conzelmann, Karl-Klaus; Pöhlmann, Stefan; Münch, Jan; Fackler, Oliver T.; Kirchhoff, Frank; Sauter, Daniel
    Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins
    In: Cell Reports Vol. 27 (2019) Nr. 7, pp. 2092 - 2104.e10
    ISSN: 2211-1247
    Online Full Text: dx.doi.org/ (Open Access)
  • Xia, Yuchen; Schlapschy, Martin; Morath, Volker; Roeder, Natalie; Vogt, Elisabeth I.; Stadler, Daniela; Cheng, Xiaoming; Dittmer, Ulf; Sutter, Kathrin; Heikenwalder, Mathias; Skerra, Arne; Protzer, Ulrike
    PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice
    In: Antiviral Research Vol. 161 (2019) pp. 134 - 143
    ISSN: 1872-9096; 0166-3542
    Online Full Text: dx.doi.org/
  • Gujer, Cornelia; Murer, Anita; Müller, Anne; Vanoaica, Danusia; Sutter, Kathrin; Jacque, Emilie; Fournier, Nathalie; Kalchschmidt, Jens; Zbinden, Andrea; Capaul, Riccarda; Dzionek, Andrzej; Mondon, Philippe; Dittmer, Ulf; Münz, Christian
    Plasmacytoid dendritic cells respond to Epstein-Barr virus infection with a distinct type I interferon subtype profile
    In: Blood Advances Vol. 3 (2019) Nr. 7, pp. 1129 - 1144
    ISSN: 2473-9537; 2473-9529
    Online Full Text: dx.doi.org/ (Open Access)
  • Lavender, Kerry J.; Pace, Craig; Sutter, Kathrin; Messer, Ronald J.; Pouncey, Dakota L.; Cummins, Nathan W.; Natesampillai, Sekar; Zheng, Jim; Goldsmith, Joshua; Widera, Marek; Van Dis, Erik S.; Phillips, Katie; Race, Brent; Dittmer, Ulf; Kukolj, George; Hasenkrug, Kim J.
    An advanced BLT-humanized mouse model for extended HIV-1 cure studies
    In: AIDS Vol. 32 (2018) Nr. 1, pp. 1 - 10
    ISSN: 1473-5571; 0269-9370
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Shen, Fang; Li, Yaming; Wang, Yang; Sozzi, Vitina; Revill, Peter A.; Liu, Jiangxia; Gao, Lu; Yang, Guang; Lu, Mengji; Sutter, Kathrin; Dittmer, Ulf; Chen, Jieliang; Yuan, Zhenghong
    Hepatitis B virus sensitivity to interferon-α in hepatocytes is more associated with cellular interferon response than with viral genotype
    In: Hepatology Vol. 67 (2018) Nr. 4, pp. 1237 - 1252
    ISSN: 1527-3350; 0270-9139
    Online Full Text: dx.doi.org/
  • Korth, Johannes; Anastasiou, Olympia E.; Verheyen, Jens; Dickow, Julia; Sertznig, Helene; Frericks, Nicola; Bleekmann, Barbara; Kribben, Andreas; Brinkhoff, Alexandra; Wilde, Benjamin; Sutter, Kathrin; Dittmer, Ulf; Ciesek, Sandra; Witzke, Oliver; Widera, Marek
    Impact of immune suppressive agents on the BK-Polyomavirus non coding control region
    In: Antiviral Research Vol. 159 (2018) pp. 68 - 76
    ISSN: 1872-9096; 0166-3542
    Online Full Text: dx.doi.org/
  • Knuschke, Torben; Rotan, Olga; Bayer, Wibke; Kollenda, Sebastian; Dickow, Julia; Sutter, Kathrin; Hansen, Wiebke; Dittmer, Ulf; Lang, Karl S.; Epple, Matthias; Buer, Jan; Westendorf, Astrid
    Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8+ T Cell Responses During Chronic Retroviral Infection
    In: Frontiers in Immunology Vol. 9 (2018) Nr. APR, pp. 614
    ISSN: 1664-3224
    Online Full Text: dx.doi.org/ (Open Access)
  • Sutter, Kathrin; Dickow, Julia; Dittmer, Ulf
    Interferon α subtypes in HIV infection
    In: Cytokine and Growth Factor Reviews Vol. 40 (2018) pp. 13 - 18
    ISSN: 1359-6101; 1359-6101
    Online Full Text: dx.doi.org/
  • Zhou, Yun; Li, Sheng; Tang, Zongsheng; Xu, Chunli; Huang, Shunmei; Wu, Jun; Dittmer, Ulf; Dickow, Julia; Sutter, Kathrin; Lu, Mengji; Yang, Dongliang; Song, Jingjiao
    Different antiviral effects of IFNα and IFNβ in an HBV mouse model
    In: Immunobiology Vol. 222 (2017) Nr. 3, pp. 562 - 570
    ISSN: 0171-2985; 1878-3279
    Online Full Text: dx.doi.org/
  • Song, Jingjiao; Li, Sheng; Zhou, Yun; Liu, Jia; Francois, Sandra; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Sutter, Kathrin
    Different antiviral effects of IFNα subtypes in a mouse model of HBV infection
    In: Scientific Reports Vol. 7 (2017) Nr. 1, pp. 334
    ISSN: 2045-2322
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Li, Yanpeng; Sun, Binlian; Esser, Stefan; Jessen, Heiko; Streeck, Hendrik; Widera, Marek; Yang, Rongge; Dittmer, Ulf; Sutter, Kathrin
    Expression pattern of individual IFNA subtypes in chronic HIV infection
    In: Journal of Interferon & Cytokine Research Vol. 37 (2017) Nr. 12, pp. 541 - 549
    ISSN: 1079-9907; 1557-7465
    Online Full Text: dx.doi.org/
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Sutter, Kathrin; Zelinskyy, Gennadiy; Windmann, Sonja; Schimmer, Simone; Paschen, Annette; Streeck, Hendrik; Hasenkrug, Kim J; Dittmer, Ulf
    Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection
    In: Scientific Reports Vol. 7 (2017) pp. 7785
    ISSN: 2045-2322
    Online Full Text: dx.doi.org/ (Open Access)
  • M. Ziegler, Susanne; Beisel, Claudia; Sutter, Kathrin; Griesbeck, Morgane; Hildebrandt, Heike; H. Hagen, Sven; Dittmer, Ulf; Altfeld, Marcus
    Human pDCs display sex-specific differences in type I interferon subtypes and interferon α/β receptor expression
    In: European Journal of Immunology Vol. 47 (2017) Nr. 2, pp. 251 - 256
    ISSN: 1521-4141; 0014-2980
    Online Full Text: dx.doi.org/
  • Schreiber, Timm; Quinting, Theresa; Dittmer, Ulf; Fandrey, Joachim; Sutter, Kathrin
    Hypoxia-inducible factor 1α is essential for macrophage-mediated erythroblast proliferation in acute friend retrovirus infection
    In: Scientific Reports Vol. 7 (2017) art. no. 17236
    ISSN: 2045-2322
    Online Full Text: dx.doi.org/ (Open Access)
  • Blömker, Dominique; Mollérus, Sina; Gibbert, Kathrin; Dittmer, Ulf; Del Rey, Adriana E.; Schedlowski, Manfred; Engler, Harald
    Inhibition of catecholamine degradation ameliorates while chemical sympathectomy aggravates the severity of acute Friend retrovirus infection in mice
    In: Brain, Behavior, and Immunity Vol. 54 (2016) Nr. May, pp. 252 - 259
    ISSN: 0889-1591
    Online Full Text: dx.doi.org/
  • Littwitz-Salomon, Elisabeth; Dittmer, Ulf; Sutter, Kathrin
    Insufficient natural killer cell responses against retroviruses : How to improve NK cell killing of retrovirus-infected cells
    In: Retrovirology Vol. 13 (2016) Nr. 1, pp. 77
    ISSN: 1742-4690
    Online Full Text: dx.doi.org/ (Open Access)
  • Lavender, Kerry J.; Gibbert, Kathrin; Peterson, Karin E.; Van Dis, Erik; Francois, Sandra; Woods, Tyson; Messer, Ronald J.; Gawanbacht, Ali; Müller, Janis A.; Münch, Jan; Phillips, Katie; Race, Brent; Harper, Michael S.; Guo, Kejun; Lee, Eric J.; Trilling, Mirko; Hengel, Hartmut; Piehler, Jacob; Verheyen, Jens; Wilson, Cara C.; Santiago, Mario L.; Hasenkrug, Kim J.; Dittmer, Ulf
    Interferon alpha subtype-specific suppression of HIV-1 infection in vivo
    In: Journal of Virology Vol. 90 (2016) Nr. 13, pp. 6001 - 6013
    ISSN: 1098-5514; 0022-538X
    Online Full Text: dx.doi.org/ (Open Access)
  • Wu, Weimin; Dietze, Kirsten; Gibbert, Kathrin; Lang, Karl S.; Trilling, Mirko; Yan, Huimin; Wu, Jun; Yang, Dongliang; Lu, Mengji; Roggendorf, Michael; Dittmer, Ulf; Liu, Jia
    TLR ligand induced IL-6 counter-regulates the anti-viral CD8+ T cell response during an acute retrovirus infection
    In: Scientific Reports Vol. 5 (2015) pp. 10501
    ISSN: 2045-2322
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Bröring, Ruth; Real, Catherine; John, Matthias J.; Jahn-Hofmann, Kerstin; Ickenstein, Ludger M.; Kleinehr, Kathrin; Paul, Andreas; Sutter, Kathrin; Dittmer, Ulf; Gerken, Guido; Schlaak, Jörg Friedrich
    Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro
    In: International Immunology Vol. 26 (2014) Nr. 1, pp. 35 - 46
    ISSN: 0953-8178; 1460-2377
    Online Full Text: dx.doi.org/
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