ZMB Member Alpaslan Tasdogan

ZMB Member
Alpaslan Tasdogan

Next ZMB-Member
Alpaslan Tasdogan portrait
© Dave Kittel/UK Essen

Prof. Dr. Dr. Alpaslan Tasdogan

Group

Tumor Metabolism

Clinic for Dermatology
University Hospital Essen
Hufelandstraße 55
45147 Essen

Research Overview

  1. Better understanding the molecular regulators of cancer metastasis
  2. Developing novel metabolic tools to study cancer metabolism in vivo
  3. Applying state-of-the art metabolic technologies to study melanoma metabolism in patient
  4. Discovering new metabolic vulnerabilities in melanoma metastasis

Press Releases

Selected Publications

    Journal articles

  • Doglioni, Ginevra; Fernández-García, Juan; Igelmann, Sebastian; Altea-Manzano, Patricia; Blomme, Arnaud; La Rovere, Rita; Liu, Xiao-Zheng; Liu, Yawen; Tricot, Tine; Nobis, Max; An, Ning; Leclercq, Marine; El Kharraz, Sarah; Karras, Panagiotis; Hsieh, Yu-Heng; Solari, Fiorella A.; Martins Nascentes Melo, Luiza; Allies, Gabrielle; Scopelliti, Annalisa; Rossi, Matteo; Vermeire, Ines; Broekaert, Dorien; Ferreira Campos, Ana Margarida; Neven, Patrick; Maetens, Marion; Van Baelen, Karen; Alkan, H. Furkan; Planque, Mélanie; Floris, Giuseppe; Sickmann, Albert; Tasdogan, Alpaslan; Marine, Jean-Christophe; Scheele, Colinda L. G. J.; Desmedt, Christine; Bultynck, Geert; Close, Pierre; Fendt, Sarah-Maria
    Aspartate signalling drives lung metastasis via alternative translation
    In: Nature Vol. 638 (2025) Nr. 2, pp. 244 - 250
    Online Full Text: dx.doi.org/
  • Dobersalske, Celia; Rauschenbach, Laurèl; Hua, Yichao; Berliner, Christoph; Steinbach, Anita; Grüneboom, Anika; Kokkaliaris, Konstantinos D.; Heiland, Dieter H.; Berger, Pia; Langer, Sarah; Tan, Chin L.; Stenzel, Martin; Landolsi, Somaya; Weber, Flora; Darkwah Oppong, Marvin; Werner, Rudolf A.; Gull, Hanah; Schröder, Thomas; Linsenmann, Thomas; Buck, Andreas K.; Gunzer, Matthias; Stuschke, Martin; Keyvani, Kathy; Forsting, Michael; Glas, Martin; Kipnis, Jonathan; Steindler, Dennis A.; Reinhardt, Hans Christian; Green, Edward W.; Platten, Michael; Tasdogan, Alpaslan; Herrmann, Ken; Rambow, Florian; Cima, Igor; Sure, Ulrich; Scheffler, Björn
    Cranioencephalic functional lymphoid units in glioblastoma
    In: Nature Medicine Vol. 30 (2024) Nr. 10, pp. 2947 - 2956
    Online Full Text: dx.doi.org/ (Open Access)
  • Tran, Diem H.; Kim, Dohun; Kesavan, Rushendhiran; Brown, Harrison; Dey, Trishna; Soflaee, Mona Hoseini; Vu, Hieu S.; Tasdogan, Alpaslan; Guo, Jason; Bezwada, Divya; Al Saad, Houssam; Cai, Feng; Solmonson, Ashley; Rion, Halie; Chabatya, Rawand; Merchant, Salma; Manales, Nathan J.; Tcheuyap, Vanina T.; Mulkey, Megan; Mathews, Thomas P.; Brugarolas, James; Morrison, Sean J.; Zhu, Hao; DeBerardinis, Ralph J.; Hoxhaj, Gerta
    De novo and salvage purine synthesis pathways across tissues and tumors
    In: Cell Vol. 187 (2024) Nr. 14, pp. 3602 - 3618.e20
    Online Full Text: dx.doi.org/
  • Rogava, Meri; Aprati, Tyler J.; Chi, Wei-Yu; Melms, Johannes C.; Hug, Clemens; Davis, Stephanie H.; Earlie, Ethan M.; Chung, Charlie; Deshmukh, Sachin K.; Wu, Sharon; Sledge, George; Tang, Stephen; Ho, Patricia; Amin, Amit Dipak; Caprio, Lindsay; Gurjao, Carino; Tagore, Somnath; Ngo, Bryan; Lee, Michael J.; Zanetti, Giorgia; Wang, Yiping; Chen, Sean; Ge, William; Melo, Luiza Martins Nascentes; Allies, Gabriele; Rösler, Jonas; Gibney, Goeffrey T.; Schmitz, Oliver J.; Sykes, Megan; Creusot, Rémi J.; Tüting, Thomas; Schadendorf, Dirk; Röcken, Martin; Eigentler, Thomas K.; Molotkov, Andrei; Mintz, Akiva; Bakhoum, Samuel F.; Beyaz, Semir; Cantley, Lewis C.; Sorger, Peter K.; Meckelmann, Sven; Tasdogan, Alpaslan; Liu, David; Laughney, Ashley M.; Izar, Benjamin
    Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation
    In: Nature Cancer Vol. 5 (2024) Nr. 3, pp. 433 - 447
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Phan, Julia; Chen, Brandon; Zhao, Zhiyu; Allies, Gabriele; Iannaccone, Antonella; Paul, Animesh; Cansiz, Feyza; Spina, Alberto; Leven, Anna-Sophia; Gellhaus, Alexandra; Schadendorf, Dirk; Kimmig, Rainer; Mettlen, Marcel; Tasdogan, Alpaslan; Morrison, Sean J.
    Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesis
    In: Science Vol. 386 (2024) Nr. 6722, eado6836
    Online Full Text: dx.doi.org/
  • Imada, Shinya; Khawaled, Saleh; Shin, Heaji; Meckelmann, Sven W.; Whittaker, Charles A.; Corrêa, Renan Oliveira; Alquati, Chiara; Lu, Yixin; Tie, Guodong; Pradhan, Dikshant; Calibasi-Kocal, Gizem; Nascentes Melo, Luiza Martins; Allies, Gabriele; Rösler, Jonas; Wittenhofer, Pia; Krystkiewicz, Jonathan; Schmitz, Oliver J.; Roper, Jatin; Vinolo, Marco Aurelio Ramirez; Ricciardiello, Luigi; Lien, Evan C.; Vander Heiden, Matthew G.; Shivdasani, Ramesh A.; Cheng, Chia-Wei; Tasdogan, Alpaslan; Yilmaz, Ömer H.
    Short-term post-fast refeeding enhances intestinal stemness via polyamines
    In: Nature Vol. 633 (2024) Nr. 8031, pp. 895 - 904
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Gao, Xiang; Murphy, Malea M.; Peyer, James G.; Ni, Yuehan; Yang, Min; Zhang, Yixuan; Guo, Jiaming; Kara, Nergis; Embree, Claire; Tasdogan, Alpaslan; Ubellacker, Jessalyn M.; Crane, Genevieve M.; Fang, Shentong; Zhao, Zhiyu; Shen, Bo; Morrison, Sean J.
    Leptin receptor⁺ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor
    In: Nature Cell Biology Vol. 25 (2023) Nr. 12, pp. 1746 - 1757
    Online Full Text: dx.doi.org/ (Open Access)
  • Solmonson, Ashley; Faubert, Brandon; Gu, Wen; Rao, Aparna; Cowdin, Mitzy A.; Menendez-Montes, Ivan; Kelekar, Sherwin; Rogers, Thomas J.; Pan, Chunxiao; Guevara, Gerardo; Tarangelo, Amy; Zacharias, Lauren G.; Martin-Sandoval, Misty S.; Do, Duyen; Pachnis, Panayotis; Dumesnil, Dennis; Mathews, Thomas P.; Tasdogan, Alpaslan; Pham, An; Cai, Ling; Zhao, Zhiyu; Ni, Min; Cleaver, Ondine; Sadek, Hesham A.; Morrison, Sean J.; DeBerardinis, Ralph J.
    Compartmentalized metabolism supports midgestation mammalian development
    In: Nature Vol. 604 (2022) Nr. 7905, pp. 349 - 353
    Online Full Text: dx.doi.org/ (Open Access)
  • Aurora, Arin B.; Khivansara, Vishal; Leach, Ashley; Gill, Jennifer G.; Martin-Sandoval, Misty; Yang, Chendong; Kasitinon, Stacy Y.; Bezwada, Divya; Tasdogan, Alpaslan; Gu, Wen; Mathews, Thomas P.; Zhao, Zhiyu; DeBerardinis, Ralph J.; Morrison, Sean J.
    Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 119 (2022) Nr. 6, e2120617119
    Online Full Text: dx.doi.org/ (Open Access)
  • Soflaee, Mona Hoseini; Kesavan, Rushendhiran; Sahu, Umakant; Tasdogan, Alpaslan; Villa, Elodie; Djabari, Zied; Cai, Feng; Tran, Diem H.; Vu, Hieu S.; Ali, Eunus S.; Rion, Halie; O’Hara, Brendan P.; Kelekar, Sherwin; Hallett, James Hughes; Martin, Misty; Mathews, Thomas P.; Gao, Peng; Asara, John M.; Manning, Brendan D.; Ben-Sahra, Issam; Hoxhaj, Gerta
    Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway
    In: Nature Communications Vol. 13 (2022) Nr. 1, 2698
    Online Full Text: dx.doi.org/ (Open Access)
  • Shen, Bo; Tasdogan, Alpaslan; Ubellacker, Jessalyn M.; Zhang, Jingzhu; Nosyreva, Elena D.; Du, Liming; Murphy, Malea M.; Hu, Shuiqing; Yi, Yating; Kara, Nergis; Liu, Xin; Guela, Shay; Jia, Yuemeng; Ramesh, Vijayashree; Embree, Claire; Mitchell, Evann C.; Zhao, Yunduo C.; Ju, Lining A.; Hu, Zhao; Crane, Genevieve M.; Zhao, Zhiyu; Syeda, Ruhma; Morrison, Sean J.
    A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis
    In: Nature Vol. 591 (2021) Nr. 7850, pp. 438 - 444
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Faubert, Brandon; Tasdogan, Alpaslan; Morrison, Sean J.; Mathews, Thomas P.; DeBerardinis, Ralph J.
    Stable isotope tracing to assess tumor metabolism in vivo
    In: Nature Protocols Vol. 16 (2021) Nr. 11, pp. 5123 - 5145
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Zhang, Jingzhu; Cohen, Adi; Shen, Bo; Du, Liming; Tasdogan, Alpaslan; Zhao, Zhiyu; Shane, Elizabeth J.; Morrison, Sean J.
    The effect of parathyroid hormone on osteogenesis is mediated partly by osteolectin
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 118 (2021) Nr. 25, e2026176118
    Online Full Text: dx.doi.org/ (Open Access)
  • Ubellacker, Jessalyn M.; Tasdogan, Alpaslan; Ramesh, Vijayashree; Shen, Bo; Mitchell, Evann C.; Martin-Sandoval, Misty S.; Gu, Zhimin; McCormick, Michael L.; Durham, Alison B.; Spitz, Douglas R.; Zhao, Zhiyu; Mathews, Thomas P.; Morrison, Sean J.
    Lymph protects metastasizing melanoma cells from ferroptosis
    In: Nature Vol. 585 (2020) Nr. 7823, pp. 113 - 118
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Tasdogan, Alpaslan; Faubert, Brandon; Ramesh, Vijayashree; Ubellacker, Jessalyn M.; Shen, Bo; Solmonson, Ashley; Murphy, Malea M.; Gu, Zhimin; Gu, Wen; Martin, Misty; Kasitinon, Stacy Y.; Vandergriff, Travis; Mathews, Thomas P.; Zhao, Zhiyu; Schadendorf, Dirk; DeBerardinis, Ralph J.; Morrison, Sean J.
    Metabolic heterogeneity confers differences in melanoma metastatic potential
    In: Nature Vol. 577 (2020) Nr. 7788, pp. 115 - 120
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)