ZMB Member Alpaslan Tasdogan

ZMB Member
Alpaslan Tasdogan

Next ZMB-Member
Alpaslan Tasdogan portrait
© Dave Kittel/UK Essen

Prof. Dr. Dr. Alpaslan Tasdogan

Group

Tumor Metabolism

Clinic for Dermatology
University Hospital Essen
Hufelandstraße 55
45147 Essen

Research Overview

  1. Better understanding the molecular regulators of cancer metastasis
  2. Developing novel metabolic tools to study cancer metabolism in vivo
  3. Applying state-of-the art metabolic technologies to study melanoma metabolism in patient
  4. Discovering new metabolic vulnerabilities in melanoma metastasis

Press Releases

Selected Publications

    Journal articles

  • Doglioni, Ginevra; Fernández-García, Juan; Igelmann, Sebastian; Altea-Manzano, Patricia; Blomme, Arnaud; La Rovere, Rita; Liu, Xiao-Zheng; Liu, Yawen; Tricot, Tine; Nobis, Max; An, Ning; Leclercq, Marine; El Kharraz, Sarah; Karras, Panagiotis; Hsieh, Yu-Heng; Solari, Fiorella A.; Martins Nascentes Melo, Luiza; Allies, Gabrielle; Scopelliti, Annalisa; Rossi, Matteo; Vermeire, Ines; Broekaert, Dorien; Ferreira Campos, Ana Margarida; Neven, Patrick; Maetens, Marion; Van Baelen, Karen; Alkan, H. Furkan; Planque, Mélanie; Floris, Giuseppe; Sickmann, Albert; Tasdogan, Alpaslan; Marine, Jean-Christophe; Scheele, Colinda L. G. J.; Desmedt, Christine; Bultynck, Geert; Close, Pierre; Fendt, Sarah-Maria
    Aspartate signalling drives lung metastasis via alternative translation
    In: Nature, Vol. 638, 2025, Nr. 2, pp. 244 – 250
    DOI
  • Kolb, Antonia; Kulis-Mandic, Ana-Marija; Klein, Matthias; Stastny, Anna; Haist, Maximilian; Votteler, Vanessa; Weidenthaler-Barth, Beate; Sinnberg, Tobias; Sucker, Antje; Allies, Gabriele; Albrecht, Jessica Lea; Tasdogan, Alpaslan; Tuettenberg, Andrea; Gaida, Matthias M.; Deppermann, Carsten; Stege, Henner; Schadendorf, Dirk; Grabbe, Stephan; Schulze-Osthoff, Klaus; Kramer, Daniela
    Constitutive expression of the transcriptional co-activator IκBζ promotes melanoma growth and immunotherapy resistance
    In: Nature Communications, Vol. 16, 2025, Nr. 1, 5387
    DOI (Open Access)
  • Minetti, Alberto; Omrani, Omid; Brenner, Christiane; Cansiz, Feyza; Imada, Shinya; Rösler, Jonas; Khawaled, Saleh; Allies, Gabriele; Meckelmann, Sven; Gebert, Nadja; Heinze, Ivonne; Rahnis, Norman; Lu, Jing; Spengler, Katrin; Rasa, Mahdi; Cirri, Emilio; Heller, Regine; Yilmaz, Ömer; Tasdogan, Alpaslan; Neri, Francesco; Ori, Alessandro
    Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis
    In: Nature Cell Biology, 2025, in press
    DOI (Open Access)
  • Melo, Luiza Martins Nascentes; Sabatier, Marie; Ramesh, Vijayashree; Szylo, Krystina J.; Fraser, Cameron S.; Pon, Alex; Mitchell, Evann C.; Servage, Kelly A.; Allies, Gabriele; Westedt, Isa V.; Cansiz, Feyza; Krystkiewicz, Jonathan; Kutritz, Andrea; Schadendorf, Dirk; Morrison, Sean J.; Ubellacker, Jessalyn M.; Sreelatha, Anju; Tasdogan, Alpaslan
    Selenoprotein O Promotes Melanoma Metastasis and Regulates Mitochondrial Complex II Activity
    In: Cancer Research, Vol. 85, 2025, Nr. 5, pp. 942 – 955
    DOI (Open Access)
  • Dobersalske, Celia; Rauschenbach, Laurèl; Hua, Yichao; Berliner, Christoph; Steinbach, Anita; Grüneboom, Anika; Kokkaliaris, Konstantinos D.; Heiland, Dieter H.; Berger, Pia; Langer, Sarah; Tan, Chin L.; Stenzel, Martin; Landolsi, Somaya; Weber, Flora; Darkwah Oppong, Marvin; Werner, Rudolf A.; Gull, Hanah; Schröder, Thomas; Linsenmann, Thomas; Buck, Andreas K.; Gunzer, Matthias; Stuschke, Martin; Keyvani, Kathy; Forsting, Michael; Glas, Martin; Kipnis, Jonathan; Steindler, Dennis A.; Reinhardt, Hans Christian; Green, Edward W.; Platten, Michael; Tasdogan, Alpaslan; Herrmann, Ken; Rambow, Florian; Cima, Igor; Sure, Ulrich; Scheffler, Björn
    Cranioencephalic functional lymphoid units in glioblastoma
    In: Nature Medicine, Vol. 30, 2024, Nr. 10, pp. 2947 – 2956
    DOI (Open Access)
  • Tran, Diem H.; Kim, Dohun; Kesavan, Rushendhiran; Brown, Harrison; Dey, Trishna; Soflaee, Mona Hoseini; Vu, Hieu S.; Tasdogan, Alpaslan; Guo, Jason; Bezwada, Divya; Al Saad, Houssam; Cai, Feng; Solmonson, Ashley; Rion, Halie; Chabatya, Rawand; Merchant, Salma; Manales, Nathan J.; Tcheuyap, Vanina T.; Mulkey, Megan; Mathews, Thomas P.; Brugarolas, James; Morrison, Sean J.; Zhu, Hao; DeBerardinis, Ralph J.; Hoxhaj, Gerta
    De novo and salvage purine synthesis pathways across tissues and tumors
    In: Cell, Vol. 187, 2024, Nr. 14, pp. 3602 – 3618.e20
    DOI
  • Rogava, Meri; Aprati, Tyler J.; Chi, Wei-Yu; Melms, Johannes C.; Hug, Clemens; Davis, Stephanie H.; Earlie, Ethan M.; Chung, Charlie; Deshmukh, Sachin K.; Wu, Sharon; Sledge, George; Tang, Stephen; Ho, Patricia; Amin, Amit Dipak; Caprio, Lindsay; Gurjao, Carino; Tagore, Somnath; Ngo, Bryan; Lee, Michael J.; Zanetti, Giorgia; Wang, Yiping; Chen, Sean; Ge, William; Melo, Luiza Martins Nascentes; Allies, Gabriele; Rösler, Jonas; Gibney, Goeffrey T.; Schmitz, Oliver J.; Sykes, Megan; Creusot, Rémi J.; Tüting, Thomas; Schadendorf, Dirk; Röcken, Martin; Eigentler, Thomas K.; Molotkov, Andrei; Mintz, Akiva; Bakhoum, Samuel F.; Beyaz, Semir; Cantley, Lewis C.; Sorger, Peter K.; Meckelmann, Sven; Tasdogan, Alpaslan; Liu, David; Laughney, Ashley M.; Izar, Benjamin
    Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation
    In: Nature Cancer, Vol. 5, 2024, Nr. 3, pp. 433 – 447
    DOI, Online Full Text (Open Access)
  • Phan, Julia; Chen, Brandon; Zhao, Zhiyu; Allies, Gabriele; Iannaccone, Antonella; Paul, Animesh; Cansiz, Feyza; Spina, Alberto; Leven, Anna-Sophia; Gellhaus, Alexandra; Schadendorf, Dirk; Kimmig, Rainer; Mettlen, Marcel; Tasdogan, Alpaslan; Morrison, Sean J.
    Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesis
    In: Science, Vol. 386, 2024, Nr. 6722, eado6836
    DOI
  • Imada, Shinya; Khawaled, Saleh; Shin, Heaji; Meckelmann, Sven W.; Whittaker, Charles A.; Corrêa, Renan Oliveira; Alquati, Chiara; Lu, Yixin; Tie, Guodong; Pradhan, Dikshant; Calibasi-Kocal, Gizem; Nascentes Melo, Luiza Martins; Allies, Gabriele; Rösler, Jonas; Wittenhofer, Pia; Krystkiewicz, Jonathan; Schmitz, Oliver J.; Roper, Jatin; Vinolo, Marco Aurelio Ramirez; Ricciardiello, Luigi; Lien, Evan C.; Vander Heiden, Matthew G.; Shivdasani, Ramesh A.; Cheng, Chia-Wei; Tasdogan, Alpaslan; Yilmaz, Ömer H.
    Short-term post-fast refeeding enhances intestinal stemness via polyamines
    In: Nature, Vol. 633, 2024, Nr. 8031, pp. 895 – 904
    DOI, Online Full Text (Open Access)
  • Gao, Xiang; Murphy, Malea M.; Peyer, James G.; Ni, Yuehan; Yang, Min; Zhang, Yixuan; Guo, Jiaming; Kara, Nergis; Embree, Claire; Tasdogan, Alpaslan; Ubellacker, Jessalyn M.; Crane, Genevieve M.; Fang, Shentong; Zhao, Zhiyu; Shen, Bo; Morrison, Sean J.
    Leptin receptor⁺ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor
    In: Nature Cell Biology, Vol. 25, 2023, Nr. 12, pp. 1746 – 1757
    DOI (Open Access)
  • Solmonson, Ashley; Faubert, Brandon; Gu, Wen; Rao, Aparna; Cowdin, Mitzy A.; Menendez-Montes, Ivan; Kelekar, Sherwin; Rogers, Thomas J.; Pan, Chunxiao; Guevara, Gerardo; Tarangelo, Amy; Zacharias, Lauren G.; Martin-Sandoval, Misty S.; Do, Duyen; Pachnis, Panayotis; Dumesnil, Dennis; Mathews, Thomas P.; Tasdogan, Alpaslan; Pham, An; Cai, Ling; Zhao, Zhiyu; Ni, Min; Cleaver, Ondine; Sadek, Hesham A.; Morrison, Sean J.; DeBerardinis, Ralph J.
    Compartmentalized metabolism supports midgestation mammalian development
    In: Nature, Vol. 604, 2022, Nr. 7905, pp. 349 – 353
    DOI (Open Access)
  • Aurora, Arin B.; Khivansara, Vishal; Leach, Ashley; Gill, Jennifer G.; Martin-Sandoval, Misty; Yang, Chendong; Kasitinon, Stacy Y.; Bezwada, Divya; Tasdogan, Alpaslan; Gu, Wen; Mathews, Thomas P.; Zhao, Zhiyu; DeBerardinis, Ralph J.; Morrison, Sean J.
    Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 119, 2022, Nr. 6, e2120617119
    DOI (Open Access)
  • Soflaee, Mona Hoseini; Kesavan, Rushendhiran; Sahu, Umakant; Tasdogan, Alpaslan; Villa, Elodie; Djabari, Zied; Cai, Feng; Tran, Diem H.; Vu, Hieu S.; Ali, Eunus S.; Rion, Halie; O’Hara, Brendan P.; Kelekar, Sherwin; Hallett, James Hughes; Martin, Misty; Mathews, Thomas P.; Gao, Peng; Asara, John M.; Manning, Brendan D.; Ben-Sahra, Issam; Hoxhaj, Gerta
    Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway
    In: Nature Communications, Vol. 13, 2022, Nr. 1, 2698
    DOI (Open Access)
  • Shen, Bo; Tasdogan, Alpaslan; Ubellacker, Jessalyn M.; Zhang, Jingzhu; Nosyreva, Elena D.; Du, Liming; Murphy, Malea M.; Hu, Shuiqing; Yi, Yating; Kara, Nergis; Liu, Xin; Guela, Shay; Jia, Yuemeng; Ramesh, Vijayashree; Embree, Claire; Mitchell, Evann C.; Zhao, Yunduo C.; Ju, Lining A.; Hu, Zhao; Crane, Genevieve M.; Zhao, Zhiyu; Syeda, Ruhma; Morrison, Sean J.
    A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis
    In: Nature, Vol. 591, 2021, Nr. 7850, pp. 438 – 444
    DOI, Online Full Text (Open Access)
  • Faubert, Brandon; Tasdogan, Alpaslan; Morrison, Sean J.; Mathews, Thomas P.; DeBerardinis, Ralph J.
    Stable isotope tracing to assess tumor metabolism in vivo
    In: Nature Protocols, Vol. 16, 2021, Nr. 11, pp. 5123 – 5145
    DOI, Online Full Text (Open Access)
  • Zhang, Jingzhu; Cohen, Adi; Shen, Bo; Du, Liming; Tasdogan, Alpaslan; Zhao, Zhiyu; Shane, Elizabeth J.; Morrison, Sean J.
    The effect of parathyroid hormone on osteogenesis is mediated partly by osteolectin
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 118, 2021, Nr. 25, e2026176118
    DOI (Open Access)
  • Ubellacker, Jessalyn M.; Tasdogan, Alpaslan; Ramesh, Vijayashree; Shen, Bo; Mitchell, Evann C.; Martin-Sandoval, Misty S.; Gu, Zhimin; McCormick, Michael L.; Durham, Alison B.; Spitz, Douglas R.; Zhao, Zhiyu; Mathews, Thomas P.; Morrison, Sean J.
    Lymph protects metastasizing melanoma cells from ferroptosis
    In: Nature, Vol. 585, 2020, Nr. 7823, pp. 113 – 118
    DOI, Online Full Text (Open Access)
  • Tasdogan, Alpaslan; Faubert, Brandon; Ramesh, Vijayashree; Ubellacker, Jessalyn M.; Shen, Bo; Solmonson, Ashley; Murphy, Malea M.; Gu, Zhimin; Gu, Wen; Martin, Misty; Kasitinon, Stacy Y.; Vandergriff, Travis; Mathews, Thomas P.; Zhao, Zhiyu; Schadendorf, Dirk; DeBerardinis, Ralph J.; Morrison, Sean J.
    Metabolic heterogeneity confers differences in melanoma metastatic potential
    In: Nature, Vol. 577, 2020, Nr. 7788, pp. 115 – 120
    DOI, Online Full Text (Open Access)