ZMB Member Alpaslan Tasdogan

ZMB Member
Alpaslan Tasdogan

Next ZMB-Member
Alpaslan Tasdogan portrait
© Dave Kittel/UK Essen

Prof. Dr. Dr. Alpaslan Tasdogan

Clinic for Dermatology
University Hospital Essen
Hufelandstraße 55
45147 Essen

Research Overview

  1. Better understanding the molecular regulators of cancer metastasis
  2. Developing novel metabolic tools to study cancer metabolism in vivo
  3. Applying state-of-the art metabolic technologies to study melanoma metabolism in patient
  4. Discovering new metabolic vulnerabilities in melanoma metastasis

Publications

    Journal articles

  • Leven, Anna-Sophia; Eisenburger, Robin Tamara; Espelage, Lena; Tasdogan, Alpaslan
    Diätetische Ansätze in der Tumortherapie
    In: TumorDiagnostik & Therapie Vol. 45 (2024) Nr. 3, pp. 186 - 194
  • Rogava, Meri; Aprati, Tyler J.; Chi, Wei-Yu; Melms, Johannes C.; Hug, Clemens; Davis, Stephanie H.; Earlie, Ethan M.; Chung, Charlie; Deshmukh, Sachin K.; Wu, Sharon; Sledge, George; Tang, Stephen; Ho, Patricia; Amin, Amit Dipak; Caprio, Lindsay; Gurjao, Carino; Tagore, Somnath; Ngo, Bryan; Lee, Michael J.; Zanetti, Giorgia; Wang, Yiping; Chen, Sean; Ge, William; Melo, Luiza Martins Nascentes; Allies, Gabriele; Rösler, Jonas; Gibney, Goeffrey T.; Schmitz, Oliver J.; Sykes, Megan; Creusot, Rémi J.; Tüting, Thomas; Schadendorf, Dirk; Röcken, Martin; Eigentler, Thomas K.; Molotkov, Andrei; Mintz, Akiva; Bakhoum, Samuel F.; Beyaz, Semir; Cantley, Lewis C.; Sorger, Peter K.; Meckelmann, Sven; Tasdogan, Alpaslan; Liu, David; Laughney, Ashley M.; Izar, Benjamin
    Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation
    In: Nature Cancer (2024) in press
  • Nascentes Melo, Luiza Martins; Kumar, Suresh; Riess, Valeria; Szylo, Krystina J.; Eisenburger, Robin; Schadendorf, Dirk; Ubellacker, Jessalyn M.; Tasdogan, Alpaslan
    Advancements in melanoma cancer metastasis models
    In: Pigment Cell and Melanoma Research Vol. 36 (2023) Nr. 2, pp. 206 - 223
  • Lodde, Georg C.; Jansen, Philipp; Herbst, Rudolf; Terheyden, Patrick; Utikal, Jochen; Pföhler, Claudia; Ulrich, Jens; Kreuter, Alexander; Mohr, Peter; Gutzmer, Ralf; Meier, Friedegund; Dippel, Edgar; Weichenthal, Michael; Sucker, Antje; Placke, Jan-Malte; Zaremba, Anne; Albrecht, Lea Jessica; Kowall, Bernd; Galetzka, Wolfgang; Becker, Jürgen C.; Tasdogan, Alpaslan; Zimmer, Lisa; Livingstone, Elisabeth; Hadaschik, Eva; Schadendorf, Dirk; Ugurel, Selma; Griewank, Klaus
    Characterisation and outcome of RAC1 mutated melanoma
    In: European Journal of Cancer (EJC) Vol. 183 (2023) pp. 1 - 10
  • Leven, Anna-Sophia; Becker, Jürgen C.; Pöttgen, Christoph; Schadendorf, Dirk; Ugurel, Selma; Tasdogan, Alpaslan
    Combined immunotherapy with ipilimumab plus nivolumab in metastatic PD-1/PD-L1-refractory Merkel cell carcinoma : a case report
    In: International Journal of Dermatology (2023) in press
  • Placke, Jan-Malte; Kimmig, Mona; Griewank, Klaus; Herbst, Rudolf; Terheyden, Patrick; Utikal, Jochen; Pföhler, Claudia; Ulrich, Jens; Kreuter, Alexander; Mohr, Peter; Gutzmer, Ralf; Meier, Friedegund; Dippel, Edgar; Welzel, Julia; Engel, Daniel Robert; Kreft, Sophia; Sucker, Antje; Lodde, Georg; Krefting, Frederik; Stoffels, Ingo; Klode, Joachim; Rösch, Alexander; Zimmer, Lisa; Livingstone, Elisabeth; Hadaschik, Eva; Becker, Jürgen; Weichenthal, Michael; Tasdogan, Alpaslan; Schadendorf, Dirk; Ugurel, Selma
    Correlation of tumor PD-L1 expression in different tissue types and outcome of PD-1-based immunotherapy in metastatic melanoma ADOREG/TRIM : Analysis of the DeCOG prospective multicenter cohort study
    In: EBioMedicine Vol. 96 (2023) 104774
  • Leven, Anna-Sophia; Eisenburger, Robin Tamara; Espelage, Lena; Tasdogan, Alpaslan
    Diätetische Ansätze in der Tumortherapie
    In: Aktuelle Dermatologie Vol. 49 (2023) Nr. 12, pp. 556 - 564
  • Tasdogan, Alpaslan; Moelleken, Maurice; Dissemond, Joachim
    Ekzeme der Wundumgebung : Genese, Diagnostik und Therapie
    In: Zeitschrift für Gerontologie und Geriatrie Vol. 56 (2023) Nr. 6, pp. 505 - 515
  • Gao, Xiang; Murphy, Malea M.; Peyer, James G.; Ni, Yuehan; Yang, Min; Zhang, Yixuan; Guo, Jiaming; Kara, Nergis; Embree, Claire; Tasdogan, Alpaslan; Ubellacker, Jessalyn M.; Crane, Genevieve M.; Fang, Shentong; Zhao, Zhiyu; Shen, Bo; Morrison, Sean J.
    Leptin receptor⁺ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor
    In: Nature Cell Biology Vol. 25 (2023) Nr. 12, pp. 1746 - 1757
  • Solari, Fiorella A.; Krahn, Daniel; Swieringa, Frauke; Verhelst, Steven; Rassaf, Tienush; Tasdogan, Alpaslan; Zahedi, Rene P.; Lorenz, Kristina; Renné, Thomas; Heemskerk, Johan W.M.; Sickmann, Albert
    Multi-omics approaches to study platelet mechanisms
    In: Current Opinion in Chemical Biology Vol. 73 (2023) 102253
  • Placke, Jan-Malte; Mertens, Delphine; Tasdogan, Alpaslan; Chorti, Eleftheria; Schadendorf, Dirk; Ugurel, Selma; Rösch, Alexander; Stoffels, Ingo; Klode, Joachim
    Multispectral optoacoustic tomography to differentiate between lymph node metastases and coronavirus-19 vaccine-associated lymphadenopathy
    In: Journal of the European Academy of Dermatology and Venereology Vol. 37 (2023) Nr. 5: Special issue on melanoma: Immune check point and BRAF‐MEK inhibitors in melanoma, pp. 907 - 913
  • Placke, Jan-Malte; Zahn, Maximilian; Zillikens, Hannah; Krefting, Frederik; Lodde, Georg; Zimmer, Lisa; Livingstone, Elisabeth; Hadaschik, Eva; Sucker, Antje; Roesch, Alexander; Tasdogan, Alpaslan; Srinivas, Nalini K.; Schadendorf, Dirk; Becker, Jürgen C.; Ugurel, Selma
    Prognostic factors in the primary care of patients with Merkel cell carcinoma : A monocentric cohort study of 108 patients from a tertiary referral centre
    In: JEADV Clinical Practice Vol. 2 (2023) Nr. 4, pp. 810 - 818
  • Solmonson, Ashley; Faubert, Brandon; Gu, Wen; Rao, Aparna; Cowdin, Mitzy A.; Menendez-Montes, Ivan; Kelekar, Sherwin; Rogers, Thomas J.; Pan, Chunxiao; Guevara, Gerardo; Tarangelo, Amy; Zacharias, Lauren G.; Martin-Sandoval, Misty S.; Do, Duyen; Pachnis, Panayotis; Dumesnil, Dennis; Mathews, Thomas P.; Tasdogan, Alpaslan; Pham, An; Cai, Ling; Zhao, Zhiyu; Ni, Min; Cleaver, Ondine; Sadek, Hesham A.; Morrison, Sean J.; DeBerardinis, Ralph J.
    Compartmentalized metabolism supports midgestation mammalian development
    In: Nature Vol. 604 (2022) Nr. 7905, pp. 349 - 353
  • Nascentes Melo, Luiza Martins; Lesner, Nicholas P.; Sabatier, Marie; Ubellacker, Jessalyn M.; Tasdogan, Alpaslan
    Emerging metabolomic tools to study cancer metastasis
    In: Trends in Cancer Vol. 8 (2022) Nr. 12, pp. 988 - 1001
  • Pachnis, Panayotis; Wu, Zheng; Faubert, Brandon; Tasdogan, Alpaslan; Gu, Wen; Shelton, Spencer; Solmonson, Ashley; Rao, Aparna D.; Kaushik, Akash K.; Rogers, Thomas J.; Ubellacker, Jessalyn M.; LaVigne, Collette A.; Yang, Chendong; Ko, Bookyung; Ramesh, Vijayashree; Sudderth, Jessica; Zacharias, Lauren G.; Martin-Sandoval, Misty S.; Do, Duyen; Mathews, Thomas P.; Zhao, Zhiyu; Mishra, Prashant; Morrison, Sean J.; DeBerardinis, Ralph J.
    In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors
    In: Science Advances Vol. 8 (2022) Nr. 35, eabn9550
  • Shen, Bo; Vardy, Kristy; Hughes, Payton; Tasdogan, Alpaslan; Zhao, Zhiyu; Yue, Rui; Crane, Genevieve M.; Morrison, Sean J.
    Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass
    In: eLife Vol. 8 (2022) pp. e42274
  • Aurora, Arin B.; Khivansara, Vishal; Leach, Ashley; Gill, Jennifer G.; Martin-Sandoval, Misty; Yang, Chendong; Kasitinon, Stacy Y.; Bezwada, Divya; Tasdogan, Alpaslan; Gu, Wen; Mathews, Thomas P.; Zhao, Zhiyu; DeBerardinis, Ralph J.; Morrison, Sean J.
    Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 119 (2022) Nr. 6, e2120617119
  • Soflaee, Mona Hoseini; Kesavan, Rushendhiran; Sahu, Umakant; Tasdogan, Alpaslan; Villa, Elodie; Djabari, Zied; Cai, Feng; Tran, Diem H.; Vu, Hieu S.; Ali, Eunus S.; Rion, Halie; O’Hara, Brendan P.; Kelekar, Sherwin; Hallett, James Hughes; Martin, Misty; Mathews, Thomas P.; Gao, Peng; Asara, John M.; Manning, Brendan D.; Ben-Sahra, Issam; Hoxhaj, Gerta
    Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway
    In: Nature Communications Vol. 13 (2022) Nr. 1, 2698
  • Shen, Bo; Tasdogan, Alpaslan; Ubellacker, Jessalyn M.; Zhang, Jingzhu; Nosyreva, Elena D.; Du, Liming; Murphy, Malea M.; Hu, Shuiqing; Yi, Yating; Kara, Nergis; Liu, Xin; Guela, Shay; Jia, Yuemeng; Ramesh, Vijayashree; Embree, Claire; Mitchell, Evann C.; Zhao, Yunduo C.; Ju, Lining A.; Hu, Zhao; Crane, Genevieve M.; Zhao, Zhiyu; Syeda, Ruhma; Morrison, Sean J.
    A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis
    In: Nature Vol. 591 (2021) Nr. 7850, pp. 438 - 444
  • Johnston, Kendra; Pachnis, Panayotis; Tasdogan, Alpaslan; Faubert, Brandon; Zacharias, Lauren G.; Vu, Hieu Sy; Rodgers-Augustyniak, Laurie; Johnson, Allison; Huang, Fang; Ricciardo, Sean; Zhao, Zhiyu; Mathews, Thomas P.; Watt, Tanya; Leavey, Patrick; DeBerardinis, Ralph J.
    Isotope tracing reveals glycolysis and oxidative metabolism in childhood tumors of multiple histologies
    In: Med Vol. 2 (2021) Nr. 4, pp. 395 - 410.e4
  • Devilbiss, Andrew W.; Zhao, Zhiyu; Martin-Sandoval, Misty S.; Ubellacker, Jessalyn M.; Tasdogan, Alpaslan; Agathocleous, Michalis; Mathews, Thomas P.; Morrison, Sean J.
    Metabolomic profiling of rare cell populations isolated by flow cytometry from tissues
    In: eLife Vol. 10 (2021) e61980
  • Tasdogan, Alpaslan; Ubellacker, Jessalyn M.; Morrison, Sean J.
    Redox regulation in cancer cells during metastasis
    In: Cancer Discovery Vol. 11 (2021) Nr. 11, pp. 2682 - 2692
  • Faubert, Brandon; Tasdogan, Alpaslan; Morrison, Sean J.; Mathews, Thomas P.; DeBerardinis, Ralph J.
    Stable isotope tracing to assess tumor metabolism in vivo
    In: Nature Protocols Vol. 16 (2021) Nr. 11, pp. 5123 - 5145
  • Zhang, Jingzhu; Cohen, Adi; Shen, Bo; Du, Liming; Tasdogan, Alpaslan; Zhao, Zhiyu; Shane, Elizabeth J.; Morrison, Sean J.
    The effect of parathyroid hormone on osteogenesis is mediated partly by osteolectin
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 118 (2021) Nr. 25, e2026176118
  • Schmid, Teresa; Maier, Julia; Martin, Melanie; Tasdogan, Alpaslan; Tausch, Eugen; Barth, Thomas F.E.; Stilgenbauer, Stephan; Bloehdorn, Johannes; Möller, Peter; Mellert, Kevin
    U-RT1 : A new model for Richter transformation
    In: Neoplasia: An International Journal for Oncology Research Vol. 23 (2021) Nr. 1, pp. 140 - 148
  • Ubellacker, Jessalyn M.; Tasdogan, Alpaslan; Ramesh, Vijayashree; Shen, Bo; Mitchell, Evann C.; Martin-Sandoval, Misty S.; Gu, Zhimin; McCormick, Michael L.; Durham, Alison B.; Spitz, Douglas R.; Zhao, Zhiyu; Mathews, Thomas P.; Morrison, Sean J.
    Lymph protects metastasizing melanoma cells from ferroptosis
    In: Nature Vol. 585 (2020) Nr. 7823, pp. 113 - 118
  • Tasdogan, Alpaslan; Faubert, Brandon; Ramesh, Vijayashree; Ubellacker, Jessalyn M.; Shen, Bo; Solmonson, Ashley; Murphy, Malea M.; Gu, Zhimin; Gu, Wen; Martin, Misty; Kasitinon, Stacy Y.; Vandergriff, Travis; Mathews, Thomas P.; Zhao, Zhiyu; Schadendorf, Dirk; DeBerardinis, Ralph J.; Morrison, Sean J.
    Metabolic heterogeneity confers differences in melanoma metastatic potential
    In: Nature Vol. 577 (2020) Nr. 7788, pp. 115 - 120
  • Tasdogan, Alpaslan; McFadden, David G.; Mishra, Prashant
    Mitochondrial DNA Haplotypes as Genetic Modifiers of Cancer
    In: Trends in Cancer Vol. 6 (2020) Nr. 12, pp. 1044 - 1058
  • Gu, Zhimin; Liu, Yuxuan; Cai, Feng; Patrick, McKenzie; Zmajkovic, Jakub; Cao, Hui; Zhang, Yuannyu; Tasdogan, Alpaslan; Chen, Mingyi; Qi, Le; Liu, Xin; Li, Kailong; Lyu, Junhua; Dickerson, Kathryn E.; Chen, Weina; Ni, Min; Merritt, Matthew E.; Morrison, Sean J.; Skoda, Radek C.; Deberardinis, Ralph J.; Xu, Jian
    Loss of EZH2 reprograms BCAA metabolism to drive leukemic transformation
    In: Cancer Discovery Vol. 9 (2019) Nr. 9, pp. 1228 - 1247
  • Kasitinon, Stacy Y.; Eskiocak, Ugur; Martin, M.; Bezwada, D.; Khivansara, Vishal; Tasdogan, Alpaslan; Zhao, Z.; Mathews, Thomas; Aurora, Arin B.; Morrison, Sean J.
    TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling
    In: Cell Reports Vol. 28 (2019) Nr. 9, pp. 2293 - 2305.e9
  • Kraus, Lea-Franziska; Scheurmann, Natalie; Frenzel, Denis F.; Tasdogan, Alpaslan; Weiss, Johannes M.
    9-cis-Retinoic acid induces a distinct regulatory dendritic cell phenotype that modulates murine delayed-type allergy
    In: Contact Dermatitis Vol. 78 (2018) Nr. 1, pp. 41 - 54
  • Ouali Alami, Najwa; Schurr, Christine; Olde Heuvel, Florian; Tang, Linyun; Li, Qian; Tasdogan, Alpaslan; Kimbara, Atsushi; Nettekoven, Matthias; Ottaviani, Giorgio; Raposo, Catarina; Röver, Stephan; Rogers-Evans, Mark; Rothenhäusler, Benno; Ullmer, Christoph; Fingerle, Jürgen; Grether, Uwe; Knuesel, Irene; Boeckers, Tobias M.; Ludolph, Albert; Wirth, Thomas; Roselli, Francesco; Baumann, Bernd
    NF-κB activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALS
    In: The EMBO Journal Vol. 37 (2018) Nr. 16, e98697
  • Schmidt, Kerstin; Zhang, Qinyu; Tasdogan, Alpaslan; Petzold, Andreas; Dahl, Andreas; Arneth, Borros M.; Slany, Robert; Fehling, Hans Jörg; Kranz, Andrea; Stewart, Adrian Francis; Anastassiadis, Konstantinos
    The H3K4 methyltransferase setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice
    In: eLife Vol. 7 (2018) e27157
  • Abstracts

  • Placke, Jan-Malte; Kimmig, M.; Griewank, Klaus; Herbst, R.; Terheyden, P.; Utikal, J. S.; Pföhler, C.; Ulrich, J.; Kreuter, A.; Mohr, P.; Gutzmer, R.; Meier, F.; Dippel, E.; Welzel, J.; Engel, Daniel Robert; Kreft, S.; Sucker, A.; Krefting, F.; Lodde, Georg C.; Stoffels, Ingo; Klode, Joachim; Rösch, Alexander; Zimmer, Lisa; Livingstone, Elisabeth; Hadaschik, Eva; Becker, Jürgen C.; Weichenthal, M.; Tasdogan, Alpaslan; Schadendorf, Dirk; Ugurel, Selma;
    Die PD-L1-Expression im Tumor prognostiziert je nach Art des untersuchten Gewebes das Outcome einer Anti-PD-1-basierten Immuntherapie bei metastasiertem Melanom
    33. Deutscher Hautkrebskongress (ADO-Jahrestagung) ; 06.–09. September 2023, Hamburg, Germany,
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Vol. 21 (2023) Nr. S4, Special Issue: Abstractband anlässlich des 33. Deutschen Hautkrebskongresses (ADO‐Jahrestagung) 06.–09. September 2023 Hamburg, pp. 27 - 28
  • Placke, Jan-Malte; Mohr, Peter; Bluhm, Leonie; Tasdogan, Alpaslan; Schadendorf, Dirk; Ugurel, Selma;
    Predictors of long-term survival of Stage IV melanoma patients: a multicenter DeCOG study on 395 patients from the prospective skin cancer registry ADOREG
    52. Tagung der Deutschen Dermatologischen Gesellschaft, Vereinigung Deutschsprachiger Dermatologen e. V., 26.-29.04.2023, Berlin,
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Vol. 21 (2023) Nr. S1, Special Issue: Abstractband anlässlich der 52. Tagung der Deutschen Dermatologischen Gesellschaft, Vereinigung Deutschsprachiger Dermatologen e. V. 26. bis 29. April 2023, Berlin, pp. 9 - 27
  • Placke, Jan-Malte; Kimmig, M.; Griewank, Klaus; Hadaschik, Eva; Herbst, R.; Terheyden, P.; Utikal, J.; Pfoehler, C.; Ulrich, J.; Kreuter, A.; Mohr, P.; Gutzmer, R.; Meier, F.; Dippel, E.; Welzel, J.; Becker, Jürgen C.; Weichenthal, M.; Tasdogan, Alpaslan; Schadendorf, Dirk; Ugurel-Becker, Selma;
    Tumor PD-L1 predicts the outcome of PD-1-based immunotherapy in metastatic melanoma depending on the type of tissue examined
    ESMO Congress 2023 ; 20 - 24 October 2023, Madrid, Spain,
    In: Annals of Oncology Vol. 34 (2023) Nr. Supplement 2: Abstract Book of the ESMO Congress 2023, 20 - 24 October 2023, pp. S695
  • Placke, Jan-Malte; Mohr, P.; Bluhm, L.; Engel, Daniel Robert; Franklin, Cindy; Zaremba, Anne; Krefting, F.; Lodde, Georg; Zimmer, Lisa; Livingstone, Elisabeth; Becker, Jürgen C.; Tasdogan, Alpaslan; Rösch, Alexander; Schadendorf, Dirk; Ugurel, Selma; et al.;
    Predictors of long-term survival of stage IV melanoma patients : a multicenter DeCOG study on 539 patients from the prospective skin cancer registry ADOREG
    32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,
    In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Vol. 20 (2022) Nr. S3, pp. 16 - 17