ZMB Member Katja Ferenz

ZMB Member
Katja Siebecke

Next ZMB-Member
Katja Ferenz portrait
© K.Siebecke

Jun.-Prof. Dr. Katja Siebecke

Group

Institute of Physiology

University Hospital Essen
Virchowstr. 171
45147 Essen

Research Overview

Development of perfluorocarbon-based artificial oxygen carriers (AOCs)

  • Perfluorocarbon-based AOCs as blood substitutes
  • Perfluorocarbon-based AOCs to improve quality of organs prior to transplantation
  • Treatment of decompression sickness with perfluorocarbon-based AOCs

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Publications

    Journal articles

  • Ferenz, Katja; Steinbicker, Andrea U.
    Corrigendum to “Artificial Oxygen Carriers - Past, Present, and Future - a Review of the Most Innovative and Clinically Relevant Concepts”
    In: The Journal of Pharmacology and Experimental Therapeutics, Vol. 392, 2025, Nr. 7, 103632
    DOI (Open Access)
  • Hosseini, Atefeh; Haj-Yehia, Elias; Korste, Sebastian; Kuzay, Yalcin; Trajkovic-Arsic, Marija; Settelmeier, Stephan; Cantore, Miriam; Ferenz, Katja; Siveke, Jens; Herrmann, Ken; Rassaf, Tienush; Hendgen-Cotta, Ulrike B.; Weber, Wolfgang A.; Varasteh, Zohreh
    How Rapidly Does the FAPI PET Signal Reverse Following Therapy? : Assessing the FAPI PET Signal in Hypertensive Cardiac Injury and Fibrosis in Mice
    In: Journal of Nuclear Medicine (JNM), Vol. 66, 2025, Nr. 11, pp. 1757 – 1763
    DOI (Open Access)
  • Nocke, Fabian; Schroer, Martin A.; Penzel, Marina; Cantore, Miriam; Steinbicker, Andrea U.; Ferenz, Katja B.
    Lecithin-Modified Nanoscale Oxygen Carriers (LENOX) : New Designed Perfluorocarbon-Based Artificial Oxygen Carriers Ready-to-Use in Clinically Relevant Media
    In: Advanced NanoBiomed Research, 2025, in press
    DOI (Open Access)
  • Feng, Huayang; Linders, Jürgen; Cantore, Miriam; Fabrizi, Jonas; Kirsten, Annika; Myszkowska, Sascha; Hillen, Eva; Uteschil, Florian; Buchholz, Sebastian; Hermsen, Andrea; Davila Garvin, Maria; Ferenz, Katja; Mayer, Christian
    Cross-linked Triblock Peptide Capsules as Potential Oxygen Carriers
    In: ChemistryOpen, Vol. 13, 2024, Nr. 4, e202300282
    DOI, Online Full Text (Open Access)
  • Dušková, Tereza; Čermák, Jan; Cantore, Miriam; Greguš, Viktor; Sydow, Jan-Eric; Henych, Jiří; Ferenz, Katja
    Harnessing Perfluorocarbon-Based nanocarriers for Rhodium(III) NHC complex Delivery : Synthesis, Characterization, and cytotoxicity evaluation
    In: Inorganica Chimica Acta, Vol. 576, 2024, 122471
    DOI
  • Semmler, Anna-Lena; Köhler, Jan-Philipp; Regolien, Lara; Bayer, Franziska; Polyansky, Nikolay; Gradhand, Elise; von Knethen, Andreas; Zacharowski, Kai; Nocke, Fabian; Ferenz, Katja B.; Schwäble, Joachim; Bonig, Halvard; Herrmann, Eva; Hornung, Isabelle; Steinbicker, Andrea U.
    Selective red blood cell depletion by apheresis in sheep causes severe normovolemic anemia
    In: Current Research in Translational Medicine, Vol. 72, 2024, Nr. 4, 103463
    DOI
  • Pizanis, Nikolaus; Dimitriou, Alexandros Merkourios; Koch, Achim; Lüdike, Peter; Papathanasiou, Maria; Rassaf, Tienush; Ruhparwar, Arjang; Schmack, Bastian; Weymann, Alexander; Ferenz, Katja; Kamler, Markus
    Introduction of machine perfusion of donor hearts in a single center in Germany
    In: International Journal of Cardiology (IJC) Heart & Vasculature, Vol. 47, 2023, 101233
    DOI, Online Full Text (Open Access)
  • Rother, Tamina; Horgby, Carina; Schmalkuche, Katharina; Burgmann, Jonathan M.; Nocke, Fabian; Jägers, Johannes; Schmitz, Jessica; Bräsen, Jan Hinrich; Cantore, Miriam; Zal, Franck; Ferenz, Katja B.; Blasczyk, Rainer; Figueiredo, Constanca
    Oxygen carriers affect kidney immunogenicity during ex-vivo machine perfusion
    In: Frontiers in Transplantation, Vol. 2, 2023, 1183908
    DOI (Open Access)
  • Hester, Sarah; Ferenz, Katja; Adick, Annika; Kakalias, Christos; Mulac, Dennis; Azhdari, Suna; Langer, Klaus
    Triglyceride-filled albumin-based nanocapsules: A promising new system to avoid discarding poorly water-soluble drug candidates
    In: International Journal of Pharmaceutics, Vol. 646, 2023, 123454
    DOI
  • Jägers, Johannes; Kirsch, Michael; Cantore, Miriam; Karaman, Ozan; Ferenz, Katja
    Artificial oxygen carriers in organ preservation : Dose dependency in a rat model of ex-vivo normothermic kidney perfusion
    In: Artificial Organs, Vol. 46, 2022, Nr. 9, pp. 1783 – 1793
    DOI (Open Access)
  • Jaegers, Johannes; Haferkamp, Sven; Arnolds, Oliver; Moog, Daniel; Wrobeln, Anna; Nocke, Fabian; Cantore, Miriam; Pütz, Stefanie; Hartwig, Anne; Franzkoch, Rico; Psathaki, Olympia Ekaterini; Jastrow, Holger; Schauerte, Carsten; Stoll, Raphael; Kirsch, Michael; Ferenz, Katja
    Deciphering the Emulsification Process to Create an Albumin-Perfluorocarbon-(o/w) Nanoemulsion with High Shelf Life and Bioresistivity
    In: Langmuir, Vol. 38, 2022, Nr. 34, pp. 10351 – 10361
    DOI
  • Hester, Sarah; Ferenz, Katja Bettina; Eitner, Susanne; Langer, Klaus
    Development of a lyophilization process for long-term storage of albumin-based perfluorodecalin-filled artificial oxygen carriers
    In: Pharmaceutics, Vol. 13, 2021, Nr. 4, 584
    DOI (Open Access)
  • Jägers, Johannes; Wrobeln, Anna; Ferenz, Katja
    Perfluorocarbon-based oxygen carriers : From physics to physiology
    In: Pflügers Archiv: European Journal of Physiology, Vol. 473, 2021, Nr. 2, pp. 139 – 150
    DOI (Open Access)
  • Wrobeln, Anna; Jägers, Johannes; Quinting, Theresa; Schreiber, Timm; Kirsch, Michael; Fandrey, Joachim; Ferenz, Katja
    Albumin-derived perfluorocarbon-based artificial oxygen carriers can avoid hypoxic tissue damage in massive hemodilution
    In: Scientific Reports, Vol. 10, 2020, Nr. 1, pp. 11950
    DOI, Online Full Text (Open Access)
  • Mayer, Dirk; Guerrero, FranÇois; Goanvec, Christelle; Hetzel, Lisa; Linders, Jürgen; Ljubkovic, Marko; Kreczy, Alfons; Mayer, Christian; Kirsch, Michael; Ferenz, Katja
    Prevention of Decompression Sickness by Novel Artificial Oxygen Carriers
    In: Medicine & Science in Sports & Exercise, Vol. 52, 2020, Nr. 10, pp. 2127 – 2135
    DOI
  • Schakowski, Kai Melvin; Linders, Jürgen; Ferenz, Katja; Kirsch, Michael
    Synthesis and characterisation of aqueous haemoglobin-based microcapsules coated by genipin-cross-linked albumin
    In: Journal of Microencapsulation, Vol. 37, 2020, Nr. 3, pp. 193 – 204
    DOI (Open Access)
  • Stokvis, A.; Cantore, M.; Fandrey, Joachim; Ferenz, Katja
    Application and effects of artificial oxygen carriers in pO2-controlled kidney cell culture
    98th Meeting of the German Physiological Society, 30 September ‐ 2 October 2019, Ulm, Germany,
    In: Acta Physiologica, Vol. 227, 2019, Nr. S719, B 04-3
    Online Full Text
  • Ferenz, Katja; Steinbicker, Andrea U.
    Artificial Oxygen Carriers-Past, Present, and Future-a Review of the Most Innovative and Clinically Relevant Concepts
    In: The Journal of Pharmacology and Experimental Therapeutics, Vol. 369, 2019, Nr. 2, pp. 300 – 310
    DOI (Open Access)
  • Mayer, Dirk; Ferenz, Katja
    Perfluorocarbons for the treatment of decompression illness : how to bridge the gap between theory and practice
    In: European Journal of Applied Physiology, Vol. 119, 2019, Nr. 11/12, pp. 2421 – 2433
    DOI (Open Access)
  • Mayer, D.; Guerrero, Francois; Goanvec, C.; Kreczy, A.; Ljubkovic, M.; Mayer, Christian; Kirsch, Michael; Ferenz, Katja
    Prevention of decompression illness : recently developed albumin-derived perfluorocarbon-based nanocapsules prove effectiveness on a clinical, biochemical and histological level
    98th Meeting of the German Physiological Society, 30 September ‐ 2 October 2019, Ulm, Germany,
    In: Acta Physiologica, Vol. 227, 2019, Nr. S719, B 04-12
    Online Full Text
  • Leu, Tristan; Schützhold, Vera; Fandrey, Joachim; Ferenz, Katja
    When the brain yearns for oxygen
    In: Neurosignals, Vol. 27, 2019, Nr. 1, pp. 50 – 61
    DOI (Open Access)
  • Köhler, Jannis; Ruschke, Jegor; Ferenz, Katja; Esen, Cemal; Kirsch, Michael; Ostendorf, Andreas
    Investigation of albumin-derived perfluorocarbon-based capsules by holographic optical trapping
    In: Biomedical Optics Express, Vol. 9, 2018, Nr. 2, pp. 743 – 754
    DOI (Open Access)
  • Wrobeln, Anna; Laudien, Julia; Groß-Heitfeld, Christoph; Linders, Jürgen; Mayer, Christian; Wilde, Benjamin; Knoll, Tanja; Naglav, Dominik; Kirsch, Michael; Ferenz, Katja
    Albumin-derived perfluorocarbon-based artificial oxygen carriers : A physico-chemical characterization and first in vivo evaluation of biocompatibility
    In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 115, 2017, pp. 52 – 64
    DOI
  • Wrobeln, Anna; Schlüter, Klaus D.; Linders, Jürgen; Zähres, Manfred; Mayer, Christian; Kirsch, Michael; Ferenz, Katja
    Functionality of albumin-derived perfluorocarbon-based artificial oxygen carriers in the Langendorff-heart
    In: Artificial Cells, Nanomedicine and Biotechnology, Vol. 45, 2017, Nr. 4, pp. 723 – 730
    DOI
  • Laudien, Julia; Groß-Heitfeld, Christoph; Mayer, Christian; de Groot, Herbert; Kirsch, Michael; Ferenz, Katja
    Perfluorodecalin-filled Poly(n-butyl-cyanoacrylate) nanocapsules as potential artificial oxygen carriers : preclinical safety and biocompatibility
    In: Journal of Nanoscience and Nanotechnology, Vol. 15, 2015, Nr. 8, pp. 5637 – 5648
    DOI
  • Stephan, Claudia; Schlawne, Carolin; Graß, Stefan; Waack, Indra N.; Ferenz, Katja; Bachmann, Michael; Barnert, Sabine; Schubert, Rolf; Bastmeyer, Martin; de Groot, Herbert; Mayer, Christian
    Artificial oxygen carriers based on perfluorodecalin-filled poly(n-butyl-cyanoacrylate) nanocapsules
    In: Journal of Microencapsulation, Vol. 31, 2014, Nr. 3, pp. 284 – 292
    DOI
  • Laudien, Julia; Naglav, Dominik; Groß-Heidfeld, Christian; Ferenz, Katja; de Groot, Herbert; Mayer, Christian; Schulz, Stephan; Schnepf, Andreas; Kirsch, Michael
    Perfluorodecalin-soluble fluorescent dyes for the monitoring of circulating nanocapsules with intravital fluorescence microscopy
    In: Journal of Microencapsulation, Vol. 31, 2014, Nr. 8, pp. 738 – 745
    DOI, Online Full Text (Open Access)
  • Ferenz, Katja; Waack, Indra N.; Laudien, Julia; Mayer, Christian; Bröcker-Preuß, Martina; de Groot, Herbert; Kirsch, Michael
    Safety of poly (ethylene glycol)-coated perfluorodecalin-filled poly (lactide-co-glycolide) microcapsules following intravenous administration of high amounts in rats
    In: Results in Pharma Sciences, Vol. 4, 2014, pp. 8 – 18
    DOI (Open Access)
  • Teloh, Johanna K.; Ferenz, Katja; Petrat, Frank; Mayer, Christian; de Groot, Herbert
    Acid-Base and electrolyte status during normovolemic hemodilution with succinylated gelatin or HES-Containing volume replacement solutions in rats
    In: PLoS ONE, Vol. 8, 2013, Nr. 9, pp. e72848
    DOI (Open Access)
  • Ferenz, Katja; Waack, Indra N.; Mayer, Christian; de Groot, Herbert; Kirsch, Michael
    Long-circulating poly(ethylene glycol)-coated poly(lactid-co-glycolid) microcapsules as potential carriers for intravenously administered drugs
    In: Journal of Microencapsulation, Vol. 30, 2013, Nr. 7, pp. 632 – 642
    DOI
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