ZMB Member Katharina Fleischhauer

ZMB Member
Katharina Fleischhauer

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Katharina Fleischhauer portrait
© UDE

Prof. Dr. Katharina Fleischhauer

Director of:

Institute for Experimental Cellular Therapy

University Hospital Essen
Hufelandstraße 55
45122 Essen

Research Overview

Focus
The Institute for Experimental Cellular Therapy is dedicated to the transplantation of allogeneic tissues, in particular of hematopoietic stem cells (HSC). HSC transplantation represents the only possibility of definitive cure for many patients affected by tumors of the blood system, such as leukemia, and its clinical application is increasing around the world. Besides offering diagnostic services for allogeneic HSC transplantation, the Institute for Experimental Cellular Therapy is focused on translational research aimed at unraveling the biological mechanisms underlying the clinical success or failure of allogeneic HSC transplantation.

  • Cellular and humoral alloreactivity and its role in transplantation
  • Molecular and functional polymorphism of the HLA system and immune-related genes

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Selected Publications

    Journal articles

  • Arrieta-Bolaños, Esteban; Crivello, Pietro; He, Meilun; Wang, Tao; Gadalla, Shahinaz M.; Paczesny, Sophie; Marsh, Steven G.E.; Lee, Stephanie J.; Spellman, Stephen R.; Bolon, Yung-Tsi; Fleischhauer, Katharina
    A core group of structurally similar HLA-DPB1 alleles drives permissiveness after hematopoietic cell transplantation
    In: Blood Vol. 140 (2022) Nr. 6, pp. 659 - 663
    Online Full Text: dx.doi.org/ (Open Access)
  • Meurer, Thuja; Crivello, Pietro; Metzing, Maximilian Frederik; Kester, Michel; Megger, Dominik A.; Chen, Weiqiang; van Veelen, PA; van Balen, Peter; Westendorf, Astrid; Homa, Georg; Layer, Sophia E.; Turki, Amin T.; Griffioen, Marieke; Horn, Peter; Sitek, Barbara; Beelen, Dietrich; Falkenburg, J.H.Frederik; Arrieta-Bolaños, Esteban; Fleischhauer, Katharina
    Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM
    In: Blood Vol. 137 (2021) Nr. 7, pp. 923 - 928
    Online Full Text: dx.doi.org/ (Open Access)
  • Lorentino, Francesca; Labopin, Myriam; Ciceri, Fabio; Vago, Luca; Fleischhauer, Katharina; Afanasyev, Boris; Kröger, Nicolaus; Cornelissen, Jan J.; Lovira, Montserrat; Meijer, Ellen; Vitek, Antonin; Elmaagacli, Ahmet; Blaise, Didier; Ruggeri, Annalisa; Chabannon, Christian; Nagler, Arnon; Mohty, Mohamad
    Post-transplantation cyclophosphamide GvHD prophylaxis after hematopoietic stem cell transplantation from 9/10 or 10/10 HLA-matched unrelated donors for acute leukemia
    In: Leukemia Vol. 35 (2021) Nr. 2, pp. 585 - 594
    Online Full Text: dx.doi.org/
  • Schetelig, Johannes; Baldauf, Henning; Heidenreich, Falk; Massalski, Carolin; Frank, Sandra; Sauter, Jürgen; Stelljes, Matthias; Ayuk, Francis Ayuketang; Bethge, Wolfgang A.; Bug, Gesine; Klein, Stefan; Wendler, Sarah; Lange, Vinzenz; de Wreede, Liesbeth C.; Fürst, Daniel; Kobbe, Guido; Ottinger, Hellmut; Beelen, Dietrich; Mytilineos, Joannis; Fleischhauer, Katharina; Schmidt, Alexander H.; Bornhäuser, Martin
    External validation of models for KIR2DS1/KIR3DL1-informed selection of hematopoietic cell donors fails
    In: Blood Vol. 135 (2020) Nr. 16, pp. 1386 - 1395
    Online Full Text: dx.doi.org/ (Open Access)
  • Toffalori, Cristina; Zito, Laura; Gambacorta, Valentina; Riba, Michaela; Oliveira, Giacomo; Bucci, Gabriele; Barcella, Matteo; Spinelli, Orietta; Greco, Raffaella; Crucitti, Lara; Cieri, Nicoletta; Noviello, Maddalena; Manfredi, Francesco; Montaldo, Elisa; Ostuni, Renato; Naldini, Matteo M.; Gentner, Bernhard; Waterhouse, Miguel; Zeiser, Robert; Finke, Jürgen; Hanoun, Maher; Beelen, Dietrich; Gojo, Ivana; Luznik, Leo; Onozawa, Masahiro; Teshima, Takanori; Devillier, Raynier; Blaise, Didier; Halkes, Constantijn J.M.; Griffioen, Marieke; Carrabba, Matteo G.; Bernardi, Massimo; Peccatori, Jacopo; Barlassina, Cristina; Stupka, Elia; Lazarevic, Dejan; Tonon, Giovanni; Rambaldi, Alessandro; Cittaro, Davide; Bonini, Chiara; Fleischhauer, Katharina; Ciceri, Fabio; Vago, Luca
    Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation
    In: Nature Medicine Vol. 25 (2019) Nr. 4, pp. 603 - 611
    Online Full Text: dx.doi.org/ (Open Access)
  • Ahci, Müberra; Toffalori, Cristina; Bouwmans, Evelien; Crivello, Pietro; Brambati, Chiara; Pultrone, Cinzia; Stempelmann, Karin; Bost, Douglas; Mazzi, Benedetta; Beelen, Dietrich; Ciceri, Fabio; Mulder, Wietse; Fleischhauer, Katharina; Vago, Luca
    A new tool for rapid and reliable diagnosis of HLA loss relapses after HSCT
    In: Blood Vol. 130 (2017) Nr. 10, pp. 1270 - 1273
    Online Full Text: dx.doi.org/
  • Eapen, Mary; Wang, Tao; Veys, Paul A; Boelens, Jaap J; St Martin, Andrew; Spellman, Stephen; Bonfim, Carmem Sales; Brady, Colleen; Cant, Andrew J; Dalle, Jean-Hugues; Davies, Stella M; Freeman, John; Hsu, Katherine C; Fleischhauer, Katharina; Kenzey, Chantal; Kurtzberg, Joanne; Michel, Gerard; Orchard, Paul J; Paviglianiti, Annalisa; Rocha, Vanderson; Veneris, Michael R; Volt, Fernanda; Wynn, Robert; Lee, Stephanie J; Horowitz, Mary M; Gluckman, Eliane; Ruggeri, Annalisa
    Allele-level HLA matching for umbilical cord blood transplantation for non-malignant diseases in children : a retrospective analysis
    In: The Lancet Haematology Vol. 4 (2017) Nr. 7, pp. e325 - e333
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Fleischhauer, Katharina; Shaw, Bronwen E.
    HLA-DP in unrelated hematopoietic cell transplantation revisited : Challenges and opportunities
    In: Blood Vol. 130 (2017) Nr. 9, pp. 1089 - 1096
    Online Full Text: dx.doi.org/ (Open Access)
  • Lindsley, R.C.; Saber, W.; Mar, B.G.; Redd, R.; Wang, T.; Haagenson, M.D.; Grauman, P.V.; Hu, Z.-H.; Spellman, S.R.; Lee, S.J.; Verneris, M.R.; Hsu, K.; Fleischhauer, Katharina; Cutler, C.; Antin, J.H.; Neuberg, D.; Ebert, B.L.
    Prognostic mutations in myelodysplastic syndrome after stem-cell transplantation
    In: The New England Journal of Medicine Vol. 376 (2017) Nr. 6, pp. 536 - 547
    Online Full Text: dx.doi.org/ (Open Access)
  • Mennonna, Daniele; Maccalli, Cristina; Romano, Michele C.; Garavaglia, Claudio; Capocefalo, Filippo; Bordoni, Roberta; Severgnini, Marco; De Bellis, Gianluca; Sidney, John; Sette, Alessandro; Gori, Alessandro; Longhi, Renato; Braga, Marco; Ghirardelli, Luca; Baldari, Ludovica; Orsenigo, Elena; Albarello, Luca; Zino, Elisabetta; Fleischhauer, Katharina; Mazzola, Gina; Ferrero, Norma; Amoroso, Antonio; Casorati, Giulia; Parmiani, Giorgio; Dellabona, Paolo
    T cell neoepitope discovery in colorectal cancer by high throughput profiling of somatic mutations in expressed genes
    In: Gut Vol. 66 (2017) Nr. 3, pp. 454 - 463
    Online Full Text: dx.doi.org/ (Open Access)
  • Crivello, Pietro; Heinold, Andreas; Rebmann, Vera; Ottinger, Hellmut; Horn, Peter; Beelen, Dietrich; Fleischhauer, Katharina
    Functional distance between recipient and donor HLA-DPB1 determines nonpermissive mismatches in unrelated HCT
    In: Blood Vol. 128 (2016) Nr. 1, pp. 120 - 129
    Online Full Text: dx.doi.org/ (Open Access)
  • Carapito, Raphael; Jung, Nicolas; Kwemou, Marius; Untrau, Meiggie; Michel, Sandra; Pichot, Angélique; Giacometti, Gaëlle; Macquin, Cécile; Ilias, Wassila; Morlon, Aurore; Kotova, Irina; Apostolova, Petya; Schmitt-Graeff, Annette; Cesbron, Anne; Gagne, Katia; Oudshoorn, Machteld; van der Holt, Bronno; Labalette, Myriam; Spierings, Eric; Picard, Christophe; Loiseau, Pascale; Tamouza, Ryad; Toubert, Antoine; Parissiadis, Anne; Dubois, Valérie; Lafarge, Xavier; Maumy-Bertrand, Myriam; Bertrand, Frédéric; Vago, Luca; Ciceri, Fabio; Paillard, Catherine; Querol, Sergi; Sierra, Jorge; Fleischhauer, Katharina; Nagler, Arnon; Labopin, Myriam; Inoko, Hidetoshi; von dem Borne, Peter A; Kuball, Jürgen; Ota, Masao; Katsuyama, Yoshihiko; Michallet, Mauricette; Lioure, Bruno; Peffault de Latour, Régis; Blaise, Didier; Cornelissen, Jan J; Yakoub-Agha, Ibrahim; Claas, Frans; Moreau, Philippe; Milpied, Noël; Charron, Dominique; Mohty, Mohamad; Zeiser, Robert; Socié, Gérard; Bahram, Seiamak
    Matching for the nonconventional MHC-I MICA gene significantly reduces the incidence of acute and chronic GVHD
    In: Blood Vol. 128 (2016) Nr. 15, pp. 1979 - 1986
    Online Full Text: dx.doi.org/ (Open Access)
  • Lorentino, F.; Ciceri, F.; Labopin, M.; Gulbas, Z.; Koc, Y.; Arcese, W.; Bruno, B.; Tischer, J.; Bacigalupo, A.; Blaise, D.; Messina, G.; Bornhauser, M.; Fleischhauer, Katharina; Beelen, Dietrich; Ruggeri, A.; Nagler, A.; Mohty, M.
    HLA Disparities Impact on Outcomes after Unmanipulated Haploidentical Hematopoietic Stem Cells Transplantation (HaploSCT) in Acute Leukemia : A Study from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
    In: Blood Vol. 126 (2015) Nr. 23, pp. 399
    Online Full Text
  • Gambacorta, V.; Oliveira, G.; Zito, L.; Toffalori, C.; Crucitti, L.; Noviello, M.; Mazzi, B.; Greco, R.; Stanghellini, MTL; Carrabba, M. G.; Bernardi, M.; Peccatori, J.; Fleischhauer, Katharina; Bonini, C.; Ciceri, F.; Vago, L.
    HLA Loss Leukemia Relapses after Partially-Incompatible Allogeneic HSCT As a Prototypical System to Investigate Natural Killer Cell Dynamics
    In: Blood Vol. 126 (2015) Nr. 23, pp. 743
    Online Full Text
  • Fleischhauer, Katharina
    Immunogenetics of HLA-DP--A New View of Permissible Mismatches
    In: The New England Journal of Medicine Vol. 373 (2015) Nr. 7, pp. 669 - 672
    Online Full Text: dx.doi.org/
  • Crucitti, L; Crocchiolo, R; Toffalori, C; Mazzi, B; Greco, R; Signori, A; Sizzano, F; Chiesa, L; Zino, E; Lupo Stanghellini, M T; Assanelli, A; Carrabba, M G; Marktel, S; Marcatti, M; Bordignon, C; Corti, C; Bernardi, M; Peccatori, J; Bonini, C; Fleischhauer, Katharina; Ciceri, F; Vago, L
    Incidence, risk factors and clinical outcome of leukemia relapses with loss of the mismatched HLA after partially incompatible hematopoietic stem cell transplantation
    In: Leukemia Vol. 29 (2015) Nr. 5, pp. 1143 - 1152
    Online Full Text: dx.doi.org/
  • Madbouly, A.; Wang, T.; Albrecht, M.; Paunic, V.; Haagenson, M. D.; Vierra-Green, C.; Fleischhauer, Katharina; Hsu, K. C.; Verneris, M. R.; Majhail, N. S.; Lee, S. J.; Spellman, S. R.; Maiers, M.
    Investigating Effect of Genetic Admixture and Donor/Recipient Genetic Disparity on Transplant Outcomes
    In: Blood Vol. 126 (2015) Nr. 23, pp. 3229
    Online Full Text
  • Toffalori, C.; Riba, M.; Zito, L.; Oliveira, G.; Bucci, G.; Barcella, M.; Spinelli, O.; Crucitti, L.; Cieri, N.; Cittaro, D.; Lazarevic, D.; Peccatori, J.; Bernardi, M.; Bonini, C.; Rambaldi, A.; Barlassina, C.; Stupka, E.; Bianchi, M.; Ciceri, F.; Fleischhauer, Katharina; Vago, L.
    LEUKEMIA RELAPSES AFTER ALLOGENENIC HSCT DISPLAY A DISTINCTIVE IMMUNE-Related signature, with functionally relevant alterations in HLA Class II antigen presentation and T-Cell costimulation
    In: Haematologica Vol. 100 (2015) Nr. Suppl. 1, pp. 183
    Online Full Text (Open Access)
  • Toffalori, C.; Riba, M.; Zito, L.; Oliveira, G.; Bucci, G.; Barcella, M.; Spinelli, O.; Crucitti, L.; Cieri, N.; Cittaro, D.; Lazarevic, D.; Peccatori, J.; Bernardi, M.; Bonini, C.; Rambaldi, A.; Barlassina, C.; Stupka, E.; Bianchi, M.; Ciceri, F.; Fleischhauer, Katharina; Vago, L.
    Leukemia relapse after allogenic HSCT displays a distinctive immune-related signature, with functionally relevant alterations in HLA Class II antigen presentation and T-Cell costimulation
    In: Haematologica Vol. 100 (2015) Nr. Suppl. 3, pp. 22
    Online Full Text (Open Access)
  • Peccatori, J; Forcina, A; Clerici, D; Crocchiolo, R; Vago, L; Stanghellini, M T L; Noviello, M; Messina, C; Crotta, A; Assanelli, A; Marktel, S; Olek, S; Mastaglio, S; Giglio, F; Crucitti, L; Lorusso, A; Guggiari, E; Lunghi, F; Carrabba, M; Tassara, M; Battaglia, M; Ferraro, A; Carbone, M R; Oliveira, G; Roncarolo, M G; Rossini, S; Bernardi, M; Corti, C; Marcatti, M; Patriarca, F; Zecca, M; Locatelli, F; Bordignon, C; Fleischhauer, Katharina; Bondanza, A; Bonini, C; Ciceri, F
    Sirolimus-based graft-versus-host disease prophylaxis promotes the in vivo expansion of regulatory T cells and permits peripheral blood stem cell transplantation from haploidentical donors
    In: Leukemia Vol. 29 (2015) Nr. 2, pp. 396 - 405
    Online Full Text: dx.doi.org/
  • Beelen, Dietrich; Crivello, P.; Heinold, Andreas; Riebschlager, S.; Heinemann, Falko M.; Rebmann, Vera; Lindemann, Monika; Ottinger, Hellmut; Horn, Peter; Fleischhauer, Katharina
    The Functional Distance Between Mismatched HLA-DPB1 Increases Risks of Relapse and Mortality after Unrelated Donor Hematopoietic Cell Transplantation for AML, ALL and MDS : A Refinement of the T Cell Epitope Group Algorithm for Permissive Mismatches
    In: Blood Vol. 126 (2015) Nr. 23, pp. 4288
    Online Full Text
  • Toffalori, C.; Riba, M.; Zito, L.; Barcella, M.; Spinelli, O.; Crucitti, L.; Cieri, N.; Peccatori, J.; Bernardi, M.; Bonini, C.; Cittaro, D.; Lazarevic, D.; Rambaldi, A.; Barlassina, C.; Stupka, E.; Ciceri, F.; Fleischhauer, Katharina; Vago, L.
    Acute Myeloid Leukemia Relapses after Allogenenic HSCT Display a Distinctive Immune-Related Signature, with Frequent and Functionally Relevant Alterations in HLA Class II Antigen Presentation and T Cell Costimulation
    In: Blood Vol. 124 (2014) Nr. 21, pp. 427
    Online Full Text
  • Vago, L.; Cittaro, D.; Toffalori, C.; Lazarevic, D.; Brambati, C.; Oliveira, G.; Bucci, G.; Crucitti, L.; Cieri, N.; Chiesa, L.; Mazzi, B.; Tresoldi, C.; Gentner, B.; Carrabba, M. G.; Bernardi, M.; Peccatori, J.; Bonini, C.; Lampasona, V.; Fleischhauer, Katharina; Ciceri, F.; Stupka, E.
    Backtracking Leukemia Clonal Evolution from Post-Transplantation Relapse to Initial Diagnosis to Identify Founder Mutations and Mechanisms of Immune Evasion
    In: Blood Vol. 124 (2014) Nr. 21, pp. 1185
    Online Full Text
  • Carapito, R.; Jung, N.; Untrau, M.; Michel, S.; Pichot, A.; Giacometti, G.; Cesbron, A.; Gagne, K.; Oudshoorn, M.; Van der Holt, R.; Labalette, M.; Spierings, E.; Picard, C.; Loiseau, P.; Tamouza, R.; Toubert, A.; Hanau, D.; Parissiadis, A.; Dubois, V.; Raus, N.; Lafarge, X.; Vago, L.; Ciceri, F.; Paillard, C.; Querol, S.; Sierra, J.; Fleischhauer, Katharina; Nagler, A.; Hoffmann, M.; Milpied, N.; Michallet, M.; Lioure, B.; de Latour, R. P.; Labopin, M.; Inoko, H.; Claas, F.; Blaise, D.; Yakoub-Agha, I.; Moreau, P.; Charron, D.; Ota, M.; Mohty, M.; Socie, G.; Bahram, S.
    Matching of MHC Class I Chain-Related Genes a and B Is Associated with Reduced Incidence of Severe Acute Graft-Versus-Host Disease after Unrelated Hematopoietic Stem Cell Transplantation
    In: Blood Vol. 124 (2014) Nr. 21, pp. 664
    Online Full Text
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