ZMB Member Heike Heuer

ZMB Member
Heike Heuer

Next ZMB-Member
Heike Heuer portrait
© UKE/Heuer

Prof. Dr. Heike Heuer

Group

Molecular Thyroidology

Clinic for Endocrinology, Diabetes & Metabolism
University Hospital Essen
Hufelandstr. 55
45122 Essen

Research Overview

  • Defining the cell-specific role of thyroid hormone transporters in health and disease
  • Development of therapeutic strategies for patients with Allan-Herndon-Dudley Syndrome (AHDS)
  • Endocrine disruptors affecting thyroid hormone transport
  • Molecular mechanismen of thyroid hormone action in brain development

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Publications

    Journal articles

  • Ullrich, Simon; Leidescher, Susanne; Feodorova, Yana; Thanisch, Katharina; Fini, Jean-Baptiste; Kaspers, Bernd; Weber, Frank; Markova, Boyka; Führer, Dagmar; Romitti, Mirian; Krebs, Stefan; Blum, Helmut; Leonhardt, Heinrich; Costagliola, Sabine; Heuer, Heike; Solovei, Irina
    Corrigendum: The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes
    In: Frontiers in Cell and Developmental Biology, Vol. 13, 2025, 1571466
    DOI (Open Access)
  • Alevyzaki, Androniki; Markova, Boyka; De Angelis, Meri; Müller, Timo D.; Chandrasekar, Akila; Müller-Fielitz, Helge; Schwaninger, Markus; Boelen, Anita; Führer, Dagmar; Mayerl, Steffen; Heuer, Heike
    Inactivation of Thyroid Hormone Transporters Mct8/Oatp1c1 in Mouse Brain Endothelial Cells Causes Region-Specific Alterations in Central Thyroid Hormone Signaling
    In: Thyroid, Vol. 35, 2025, Nr. 7, pp. 816 – 827
    DOI
  • Alcaide Martin, Andrea; Bauer, Reinhard; Führer-Sakel, Dagmar; Heuer, Heike; Mayerl, Steffen
    Increased seizure susceptibility in thyroid hormone transporter Mct8/Oatp1c1 knockout mice is associated with altered neurotransmitter systems development
    In: Progress in Neurobiology, Vol. 247, 2025, 102731
    DOI (Open Access)
  • Mayerl, Steffen; Martin, Andrea Alcaide; Bauer, Reinhard; Heuer, Heike
    Sciatic nerve analysis in thyroid hormone transporters Mct8 and Oatp1c1 knockout mice
    In: European Thyroid Journal, Vol. 14, 2025, Nr. 1, e240248
    DOI (Open Access)
  • Wenzek, Christina; Knuschke, Torben; Hönes, G. Sebastian; Boelen, Anita; Klopfleisch, Robert; Zwanziger, Denise; Heuer, Heike; Westendorf, Astrid; Möller, Lars; Führer, Dagmar
    Thyroid hormone receptor α signaling shapes innate and adaptive immune responses during viral infection
    In: European Thyroid Journal, 2025, in press
    DOI (Open Access)
  • Ullrich, Daniel; Führer, Dagmar; Heuer, Heike; Mayerl, Steffen; Haupeltshofer, Steffen; Schmitt, Linda-Isabell; Leo, Markus; Szepanowski, Rebecca D.; Hagenacker, Tim; Schwaninger, Markus; Kleinschnitz, Christoph; Langhauser, Friederike
    Triiodothyronine treatment in mice improves stroke outcome and reduces blood–brain barrier damage
    In: European Thyroid Journal, Vol. 14, 2025, Nr. 1, e240143
    DOI (Open Access)
  • Spangenberg, Philippa; Bessler, Sebastian; Widera, Lars; Bottek, Jenny; Richter, Mathis; Thiebes, Stephanie; Siemes, Devon; Krauß, Sascha D.; Migas, Lukasz G.; Kasarla, Siva Swapna; Phapale, Prasad; Kleesiek, Jens; Führer, Dagmar; Möller, Lars; Heuer, Heike; Van de Plas, Raf; Gunzer, Matthias; Soehnlein, Oliver; Soltwisch, Jens; Shevchuk, Olga; Dreisewerd, Klaus; Engel, Daniel R.
    msiFlow : automated workflows for reproducible and scalable multimodal mass spectrometry imaging and microscopy data analysis
    In: Nature Communications, Vol. 16, 2025, Nr. 1, 1065
    DOI (Open Access)
  • Chen, Zhongli; Yildiz, Sena; Markova, Boyka; de Rooij, Linda J.; Leeuwenburgh, Selmar; Hamers, Timo; Peeters, Robin P.; Heuer, Heike; Meima, Marcel E.; Visser, W. Edward
    3,3′,5-Triiodothyroacetic Acid Transporters
    In: Thyroid, Vol. 34, 2024, Nr. 8, pp. 1027 – 1037
    DOI
  • Liu, Ye; Ng, Lily; Liu, Hong; Heuer, Heike; Forrest, Douglas
    Cone photoreceptor differentiation regulated by thyroid hormone transporter MCT8 in the retinal pigment epithelium
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 121, 2024, Nr. 30, e2402560121
    DOI (Open Access)
  • Markova, Boyka; Mayerl, Steffen; Heuer, Heike
    Toward a treatment for thyroid hormone transporter MCT8 deficiency : Achievements and challenges
    In: European Thyroid Journal, Vol. 13, 2024, Nr. 6, e240286
    DOI (Open Access)
  • Venugopalan, Vaishnavi; Rehders, Maren; Weber, Jonas; Rodermund, Lisa; Al-Hashimi, Alaa; Bargmann, Tonia; Golchert, Janine; Reinecke, Vivien; Homuth, Georg; Völker, Uwe; Verrey, Francois; Kirstein, Janine; Heuer, Heike; Schweizer, Ulrich; Braun, Doreen; Wirth, Eva K.; Brix, Klaudia
    Lack of L-type amino acid transporter 2 in murine thyroid tissue induces autophagy
    In: Journal of Molecular Endocrinology, Vol. 70, 2023, Nr. 1, e220060
    DOI
  • Siemes, Devon; Vancamp, Pieter; Markova, Boyka; Spangenberg, Philippa; Shevchuk, Olga; Siebels, Bente; Schlüter, Hartmut; Mayerl, Steffen; Heuer, Heike; Engel, Daniel Robert
    Proteome Analysis of Thyroid Hormone Transporter Mct8/Oatp1c1-Deficient Mice Reveals Novel Dysregulated Target Molecules Involved in Locomotor Function
    In: Cells, Vol. 12, 2023, Nr. 20, 2487
    DOI (Open Access)
  • Ullrich, Simon; Leidescher, Susanne; Feodorova, Yana; Thanisch, Katharina; Fini, Jean-Baptiste; Kaspers, Bernd; Weber, Frank; Markova, Boyka; Führer, Dagmar; Romitti, Mirian; Krebs, Stefan; Blum, Helmut; Leonhardt, Heinrich; Costagliola, Sabine; Heuer, Heike; Solovei, Irina
    The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes
    In: Frontiers in Cell and Developmental Biology, Vol. 11, 2023, 1265407
    DOI (Open Access)
  • Mayerl, Steffen; Heuer, Heike
    Thyroid hormone transporter Mct8/Oatp1c1 deficiency compromises proper oligodendrocyte maturation in the mouse CNS
    In: Neurobiology of Disease, Vol. 184, 2023, 106195
    DOI, Online Full Text (Open Access)
  • Chen, Jiesi; Salveridou, Eva; Liebmann, Lutz; Sundaram, Sivaraj M.; Doycheva, Denica; Markova, Boyka; Hübner, Christian A.; Boelen, Anita; Visser, W. Edward; Heuer, Heike; Mayerl, Steffen
    Triac Treatment Prevents Neurodevelopmental and Locomotor Impairments in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice
    In: International Journal of Molecular Sciences (IJMS), Vol. 24, 2023, Nr. 4, 3452
    DOI (Open Access)
  • Liao, Xiao-Hui; Avalos, Pablo; Shelest, Oksana; Ofan, Raz; Shilo, Michael; Bresee, Catherine; Likhite, Shibi; Vit, Jean-Philippe; Heuer, Heike; Kaspar, Brian; Meyer, Kathrin; Dumitrescu, Alexandra M.; Refetoff, Samuel; Svendsen, Clive N.; Vatine, Gad D.
    AAV9-MCT8 Delivery at Juvenile Stage Ameliorates Neurological and Behavioral Deficits in a Mouse Model of MCT8-Deficiency
    In: Thyroid, Vol. 32, 2022, Nr. 7, pp. 849 – 859
    DOI (Open Access)
  • Hu, Yalan; Lauffer, Peter; Stewart, Michelle; Codner, Gemma; Mayerl, Steffen; Heuer, Heike; Ng, Lily; Forrest, Douglas; van Trotsenburg, Paul; Jongejan, Aldo; Fliers, Eric; Hennekam, Raoul; Boelen, Anita
    An animal model for Pierpont syndrome : A mouse bearing the Tbl1xr1 (Y446C/Y446C) mutation
    In: Human Molecular Genetics, Vol. 31, 2022, Nr. 17, pp. 2951 – 2963
    DOI (Open Access)
  • Mayerl, Steffen; Alcaide Martin, Andrea; Bauer, Reinhard; Schwaninger, Markus; Heuer, Heike; ffrench-Constant, Charles
    Distinct Actions of the Thyroid Hormone Transporters Mct8 and Oatp1c1 in Murine Adult Hippocampal Neurogenesis
    In: Cells, Vol. 11, 2022, Nr. 3, 524
    DOI, Online Full Text (Open Access)
  • Groeneweg, Stefan; van Geest, Ferdy S.; Chen, Zhongli; Farina, Stefania; van Heerebeek, Ramona E.A.; Meima, Marcel E.; Peeters, Robin P.; Heuer, Heike; Medici, Marco; Visser, W. Edward
    Functional Characterization of the Novel and Specific Thyroid Hormone Transporter SLC17A4
    In: Thyroid, Vol. 32, 2022, Nr. 3, pp. 326 – 335
    DOI
  • Sundaram, Sivaraj M.; Arrulo Pereira, Adriana; Müller-Fielitz, Helge; Köpke, Hannes; De Angelis, Meri; Müller, Timo D.; Heuer, Heike; Körbelin, Jakob; Krohn, Markus; Mittag, Jens; Nogueiras, Ruben; Prevot, Vincent; Schwaninger, Markus
    Gene therapy targeting the blood–brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency
    In: Brain: A Journal of Neurology, Vol. 145, 2022, Nr. 12, pp. 4264 – 4274
    DOI (Open Access)
  • Reinwald, Jonathan Rochus; Weber-Fahr, Wolfgang; Cosa-Linan, Alejandro; Becker, Robert; Sack, Markus; Falfan-Melgoza, Claudia; Gass, Natalia; Braun, Urs; Clemm von Hohenberg, Christian; Chen, Jiesi; Mayerl, Steffen; Muente, Thomas F.; Heuer, Heike; Sartorius, Alexander
    TRIAC Treatment Improves Impaired Brain Network Function and White Matter Loss in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice
    In: International Journal of Molecular Sciences (IJMS), Vol. 23, 2022, Nr. 24, 15547
    DOI (Open Access)
  • Lademann, Franziska; Mayerl, Steffen; Tsourdi, Elena; Verrey, Francois; Leitch, Victoria D.; Williams, Graham R.; Bassett, J. H. Duncan; Hofbauer, Lorenz C.; Heuer, Heike; Rauner, Martina
    The Thyroid Hormone Transporter MCT10 Is a Novel Regulator of Trabecular Bone Mass and Bone Turnover in Male Mice
    In: Endocrinology, Vol. 163, 2022, Nr. 1, bqab218
    DOI (Open Access)
  • Mayerl, Steffen; Chen, Jiesi; Salveridou, Eva; Boelen, Anita; Darras, Veerle M; Heuer, Heike
    Thyroid Hormone Transporter Deficiency in Mice Impacts Multiple Stages of GABAergic Interneuron Development
    In: Cerebral Cortex, Vol. 32, 2022, Nr. 2, pp. 329 – 341
    DOI (Open Access)
  • Luongo, Cristina; Butruille, Lucile; Sébillot, Anthony; Le Blay, Karine; Schwaninger, Markus; Heuer, Heike; Demeneix, Barbara A.; Remaud, Sylvie
    Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone
    In: Stem Cell Reports, Vol. 16, 2021, Nr. 2, pp. 337 – 353
    DOI (Open Access)
  • Morte, Beatriz; Gil-Ibañez, Pilar; Heuer, Heike; Bernal, Juan
    Brain gene expression in systemic hypothyroidism and mouse models of MCT8 deficiency : The Mct8-Oatp1c1-Dio2 triad
    In: Thyroid, Vol. 31, 2021, Nr. 6, pp. 985 – 993
    DOI (Open Access)
  • Jonklaas, Jacqueline; Bianco, Antonio C.; Cappola, Anne R.; Celi, Francesco S.; Fliers, Eric; Heuer, Heike; McAninch, Elizabeth A.; Möller, Lars; Nygaard, Birte; Sawka, Anna M.; Watt, Torquil; Dayan, Colin M.
    Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism : A Consensus Document
    In: Thyroid, Vol. 31, 2021, Nr. 2, pp. 156 – 182
    DOI, Online Full Text (Open Access)
  • Jonklaas, Jacqueline; Bianco, Antonio C.; Cappola, Anne R.; Celi, Francesco S.; Fliers, Eric; Heuer, Heike; McAninch, Elizabeth A.; Möller, Lars; Nygaard, Birte; Sawka, Anna M.; Watt, Torquil; Dayan, Colin M.
    Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document
    In: European Thyroid Journal, Vol. 10, 2021, Nr. 1, pp. 10 – 38
    DOI (Open Access)
  • Kowallick, Mirjam; Serdar, Meray; Markova, Boyka; Salveridou, Eva; Felderhoff-Müser, Ursula; Führer-Sakel, Dagmar; Heuer, Heike; Bendix, Ivo; Dewan, Monia Vanessa
    Hyperoxia Leads to Transient Endocrine Alterations in the Neonatal Rat During Postnatal Development
    In: Frontiers in Pediatrics, Vol. 9, 2021, 723928
    DOI, Online Full Text (Open Access)
  • Vatine, Gad D.; Shelest, Oksana; Barriga, Bianca K.; Ofan, Raz; Rabinski, Tatyana; Mattis, Virginia B.; Heuer, Heike; Svendsen, Clive N.
    Oligodendrocyte progenitor cell maturation is dependent on dual function of MCT8 in the transport of thyroid hormone across brain barriers and the plasma membrane
    In: Glia, Vol. 69, 2021, Nr. 9, pp. 2146 – 2159
    DOI
  • Shukla, Shalmali; Haenold, Ronny; Urbánek, Pavel; Frappart, Lucien; Monajembashi, Shamci; Grigaravicius, Paulius; Nagel, Sigrun; Min, Woo Kee; Tapias, Alicia; Kassel, Olivier; Heuer, Heike; Wang, Zhao-Qi; Ploubidou, Aspasia; Herrlich, Peter
    TRIP6 functions in brain ciliogenesis
    In: Nature Communications, Vol. 12, 2021, Nr. 1, 5887
    DOI (Open Access)
  • Venugopalan, Vaishnavi; Al-Hashimi, Alaa; Weber, Jonas; Rehders, Maren; Qatato, Maria; Wirth, Eva K.; Schweizer, Ulrich; Heuer, Heike; Verrey, François; Brix, Klaudia
    The amino acid transporter mct10/tat1 is important to maintain the tsh receptor at its canonical basolateral localization and assures regular turnover of thyroid follicle cells in male mice
    In: International Journal of Molecular Sciences (IJMS), Vol. 22, 2021, Nr. 11, 5776
    DOI (Open Access)
  • Venugopalan, Vaishnavi; Al-Hashimi, Alaa; Rehders, Maren; Golchert, Janine; Reinecke, Vivien; Homuth, Georg; Völker, Uwe; Manirajah, Mythili; Touzani, Adam; Weber, Jonas; Bogyo, Matthew S.; Verrey, Francois; Wirth, Eva K.; Schweizer, Ulrich; Heuer, Heike; Kirstein, Janine; Brix, Klaudia
    The thyroid hormone transporter MCT8 restricts cathepsin-mediated thyroglobulin processing in male mice through thyroid auto-regulatory mechanisms that encompass autophagy
    In: International Journal of Molecular Sciences (IJMS), Vol. 22, 2021, Nr. 1, pp. 462
    DOI (Open Access)
  • Herrmann, Beate; Harder, Lisbeth; Oelkrug, Rebecca; Chen, Jiesi; Gachkar, Sogol; Nock, Sebastian; Resch, Julia; Korkowski, Markus; Heuer, Heike; Mittag, Jens
    Central Hypothyroidism Impairs Heart Rate Stability and Prevents Thyroid Hormone-Induced Cardiac Hypertrophy and Pyrexia
    In: Thyroid, Vol. 30, 2020, Nr. 8, pp. 1205 – 1216
    DOI
  • Mayerl, Steffen; Heuer, Heike; Ffrench-Constant, Charles
    Hippocampal Neurogenesis Requires Cell-Autonomous Thyroid Hormone Signaling
    In: Stem Cell Reports, Vol. 14, 2020, Nr. 5, pp. 845 – 860
    DOI (Open Access)
  • Lademann, Franziska; Tsourdi, Elena; Rijntjes, Eddy; Köhrle, Josef; Hofbauer, Lorenz C.; Heuer, Heike; Rauner, Martina
    Lack of the Thyroid Hormone Transporter Mct8 in Osteoblast and Osteoclast Progenitors Increases Trabecular Bone in Male Mice
    In: Thyroid, Vol. 30, 2020, Nr. 2, pp. 329 – 342
    DOI
  • Bottek, Jenny; Soun, Camille; Lill, Julia K.; Dixit, Akanksha; Thiebes, Stephanie; Beerlage, Anna-Lena; Horstmann, Marius; Urbanek, Annett; Heuer, Heike; Uszkoreit, Julian; Eisenacher, Martin; Bracht, Thilo; Sitek, Barbara; Hoffmann, Franziska; Vijitha, Nirojah; von Eggeling, Ferdinand; Engel, Daniel Robert
    Spatial proteomics revealed a CX₃CL1-dependent crosstalk between the urothelium and relocated macrophages through IL-6 during an acute bacterial infection in the urinary bladder
    In: Mucosal Immunology, Vol. 13, 2020, Nr. 4, pp. 702 – 714
    DOI (Open Access)
  • Groeneweg, Stefan; van Geest, Ferdy S.; Peeters, Robin P.; Heuer, Heike; Visser, W. Edward
    Thyroid Hormone Transporters
    In: Endocrine Reviews, Vol. 41, 2020, Nr. 2, pp. 146 – 201
    DOI (Open Access)
  • Salveridou, Eva; Mayerl, Steffen; Sundaram, Sivaraj Mohana; Markova, Boyka; Heuer, Heike
    Tissue-Specific Function of Thyroid Hormone Transporters : New Insights from Mouse Models
    In: Experimental and Clinical Endocrinology & Diabetes, Vol. 128, 2020, Nr. 6-7, pp. 423 – 437
    DOI
  • Kerp, Helena; Engels, Kathrin; Kramer, Frederike; Doycheva, Denica; Sebastian Hönes, Georg; Zwanziger, Denise; Christian Moeller, Lars; Heuer, Heike; Führer, Dagmar
    Age effect on thyroid hormone brain response in male mice
    In: Endocrine, Vol. 66, 2019, Nr. 3, pp. 596 – 606
    DOI
  • Walter, Kyla M.; Dach, Katharina; Hayakawa, Keri; Giersiefer, Susanne; Heuer, Heike; Lein, Pamela J.; Fritsche, Ellen
    Ontogenetic expression of thyroid hormone signaling genes : An in vitro and in vivo species comparison
    In: PLoS ONE, Vol. 14, 2019, Nr. 9, pp. 0221230
    DOI (Open Access)
  • Sharlin, David S; Ng, Lily; Verrey, François; Visser, Theo J; Liu, Ye; Olszewski, Rafal T; Hoa, Michael; Heuer, Heike; Forrest, Douglas
    Deafness and loss of cochlear hair cells in the absence of thyroid hormone transporters Slc16a2 (Mct8) and Slc16a10 (Mct10).
    In: Scientific Reports, Vol. 8, 2018, Nr. 1, pp. 4403
    DOI (Open Access)
  • Harder, L; Dudazy-Gralla, S; Müller-Fielitz, H; Hjerling Leffler, J; Vennström, B; Heuer, Heike; Mittag, J
    Maternal thyroid hormone is required for parvalbumin neurone development in the anterior hypothalamic area
    In: Journal of Neuroendocrinology, Vol. 30, 2018, Nr. 3, pp. e12573
    DOI (Open Access)
  • Strømme, Petter; Groeneweg, Stefan; Lima de Souza, Elaine C.; Zevenbergen, Chantal; Torgersbråten, Anette; Holmgren, Asbjørn; Gurcan, Ebrar; Meima, Marcel E.; Peeters, Robin P.; Visser, W Edward; Høneren Johansson, Linda; Babovic, Almira; Zetterberg, Henrik; Heuer, Heike; Frengen, Eirik; Misceo, Doriana; Visser, Theo J.
    Mutated Thyroid Hormone Transporter OATP1C1 Associates with Severe Brain Hypometabolism and Juvenile Neurodegeneration
    In: Thyroid, Vol. 28, 2018, Nr. 11, pp. 1406 – 1415
    DOI (Open Access)
  • Mayerl, Steffen; Schmidt, Manuel; Doycheva, Denica; Darras, Veerle M.; Hüttner, Sören S.; Boelen, Anita; Visser, Theo J.; Kaether, Christoph; Heuer, Heike; von Maltzahn, Julia
    Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration
    In: Stem Cell Reports, Vol. 10, 2018, Nr. 6, pp. 1959 – 1974
    DOI (Open Access)