ZMB Member Josephine Herz

ZMB Member
Josephine Herz

Next ZMB-Member
Josephine Herz portrait
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PD Dr. Josephine Herz

Group

Experimental Perinatal Neuroscience

Pediatrics Clinic I
University Hospital Essen
Hufelandstr. 55
45122 Essen

Research Overview

The questions of the experimental perinatal neurosciences are aimed at uncovering cellular and molecular mechanisms of typical diseases of premature babies and sick newborns, with the integrity of the central nervous system being the focus of research.

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Selected Publications

    Journal articles

  • Obst, Stefanie; Serdar, Meray; Herz, Josephine; Kempe, Karina; Assili, Meriem; Rizazad, Mandana; Hirani, Dharmesh; Alejandre Alcazar, Miguel A.; Endesfelder, Stefanie; Möbius, Marius A.; Rüdiger, Mario; Felderhoff-Müser, Ursula; Bendix, Ivo
    A Novel Model for Simultaneous Evaluation of Hyperoxia-Mediated Brain and Lung Injury in Neonatal Rats
    In: Cells, Vol. 14, 2025, Nr. 6, pp. 443
    DOI (Open Access)
  • Obst, Stefanie; Serdar, Meray; Kempe, Karina; Hirani, Dharmesh; Felderhoff-Müser, Ursula; Herz, Josephine; Alejandre Alcazar, Miguel A.; Bendix, Ivo
    Prolonged Exposure to Neonatal Hyperoxia Impairs Neuronal and Oligodendrocyte Maturation Associated with Long-Lasting Neuroinflammatory Responses in Juvenile Mice
    In: Cells, Vol. 14, 2025, Nr. 15, 1141
    DOI, Online Full Text (Open Access)
  • Wang, Chen; Börger, Verena; Mohamud Yusuf, Ayan; Tertel, Tobias; Stambouli, Oumaima; Murke, Florian; Freund, Nico; Kleinschnitz, Christoph; Herz, Josephine; Gunzer, Matthias; Popa-Wagner, Aurel; Döppner, Thorsten R.; Giebel, Bernd; Hermann, Dirk M.
    Postischemic Neuroprotection Associated With Anti-Inflammatory Effects by Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Aged Mice
    In: Stroke, Vol. 53, 2022, Nr. 1, pp. E14 – E18
    DOI (Open Access)
  • Beckmann, Lucia; Obst, Stefanie; Labusek, Nicole; Abberger, Hanna; Köster, Christian; Klein-Hitpaß, Ludger; Schumann, Sven; Kleinschnitz, Christoph; Hermann, Dirk M.; Felderhoff-Müser, Ursula; Bendix, Ivo; Hansen, Wiebke; Herz, Josephine
    Regulatory T Cells Contribute to Sexual Dimorphism in Neonatal Hypoxic-Ischemic Brain Injury
    In: Stroke, Vol. 53, 2022, Nr. 2, pp. 381 – 390
    DOI (Open Access)
  • Mülling, Kerstin; Fischer, Alexa Josephine; Siakaeva, Elena; Richter, Mathis; Bordbari, Sharareh; Spyra, Ilona; Köster, Christian; Hermann, Dirk M.; Gunzer, Matthias; Felderhoff-Müser, Ursula; Bendix, Ivo; Jablonska, Jadwiga; Herz, Josephine
    Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia-ischemia
    In: Brain, Behavior and Immunity, Vol. 92, 2021, pp. 234 – 244
    DOI (Open Access)
  • Serdar, Meray; Kempe, Karina; Herrmann, Ralf; Picard, Daniel; Remke, Marc; Herz, Josephine; Bendix, Ivo; Felderhoff-Müser, Ursula; Sabir, Hemmen
    Involvement of CXCL1/CXCR2 During Microglia Activation Following Inflammation-Sensitized Hypoxic-Ischemic Brain Injury in Neonatal Rats
    In: Frontiers in Neurology, Vol. 11, 2020, pp. 540878
    DOI, Online Full Text (Open Access)
  • Kaminski, Nicole; Köster, Christian; Mouloud, Yanis; Börger, Verena; Felderhoff-Müser, Ursula; Bendix, Ivo; Giebel, Bernd; Herz, Josephine
    Mesenchymal Stromal Cell-Derived Extracellular Vesicles Reduce Neuroinflammation, Promote Neural Cell Proliferation and Improve Oligodendrocyte Maturation in Neonatal Hypoxic-Ischemic Brain Injury
    In: Frontiers in Cellular Neuroscience, Vol. 14, 2020, pp. 601176
    DOI, Online Full Text (Open Access)
  • Dewan, Monia Vanessa; Serdar, Meray; van de Looij, Yohan; Kowallick, Mirjam; Hadamitzky, Martin; Endesfelder, Stefanie; Fandrey, Joachim; Sizonenko, Stéphane V.; Herz, Josephine; Felderhoff-Müser, Ursula; Bendix, Ivo
    Repetitive Erythropoietin Treatment Improves Long-Term Neurocognitive Outcome by Attenuating Hyperoxia-Induced Hypomyelination in the Developing Brain
    In: Frontiers in Neurology, Vol. 11, 2020, pp. 804
    DOI, Online Full Text (Open Access)
  • Jungner, Åsa; Vallius Kvist, Suvi; Romantsik, Olga; Bruschettini, Matteo; Ekström, Claes; Bendix, Ivo; Herz, Josephine; Felderhoff-Müser, Ursula; Bibic, Adnan; In'T Zandt, René; Gram, Magnus; Ley, David
    White Matter Brain Development after Exposure to Circulating Cell-Free Hemoglobin and Hyperoxia in a Rat Pup Model
    In: Developmental Neuroscience, Vol. 41, 2020, Nr. 3-4, pp. 234 – 246
    DOI (Open Access)
  • Serdar, Meray; Mordelt, Annika; Müser, Katharina; Kempe, Karina; Felderhoff-Müser, Ursula; Herz, Josephine; Bendix, Ivo
    Detrimental Impact of Energy Drink Compounds on Developing Oligodendrocytes and Neurons
    In: Cells, Vol. 8, 2019, Nr. 11, pp. 1381
    DOI, Online Full Text (Open Access)
  • Serdar, Meray; Kempe, Karina; Rizazad, Mandana; Herz, Josephine; Bendix, Ivo; Felderhoff-Müser, Ursula; Sabir, Hemmen
    Early pro-inflammatory microglia activation after inflammation-sensitized hypoxic-ischemic brain injury in neonatal rats
    In: Frontiers in Cellular Neuroscience, Vol. 13, 2019, pp. 237
    DOI (Open Access)
  • Herz, Josephine; Köster, Christian; Reinboth, Barbara S.; Dzietko, Mark; Hansen, Wiebke; Sabir, Hemmen; van Velthoven, Cindy; Bendix, Ivo; Felderhoff-Müser, Ursula
    Interaction between hypothermia and delayed mesenchymal stem cell therapy in neonatal hypoxic-ischemic brain injury
    In: Brain, Behavior and Immunity, Vol. 70, 2018, pp. 118 – 130
    DOI (Open Access)
  • Herz, Josephine; Köster, Christian; Crasmöller, Marius; Abberger, Hanna; Hansen, Wiebke; Felderhoff-Müser, Ursula; Bendix, Ivo
    Peripheral T cell depletion by FTY720 exacerbates hypoxic-ischemic brain injury in neonatal mice
    In: Frontiers in Immunology, Vol. 9, 2018, pp. 1696
    DOI (Open Access)
  • Serdar, Meray; Herz, Josephine; Kempe, Karina; Winterhager, Elke; Jastrow, Holger; Heumann, Rolf; Felderhoff-Müser, Ursula; Bendix, Ivo
    Protection of oligodendrocytes through neuronal overexpression of the small GTPase ras in hyperoxia-induced neonatal brain injury
    In: Frontiers in Neurology, Vol. 9, 2018, pp. 175
    DOI, Online Full Text (Open Access)
  • Drommelschmidt, Karla; Serdar, Meray; Bendix, Ivo; Herz, Josephine; Bertling, Frederik; Prager, Sebastian; Keller, Matthias; Ludwig, Anna-Kristin; Duhan, Vikas; Radtke, Stefan; de Miroschedji, Kyra; Horn, Peter; van de Looij, Yohan; Giebel, Bernd; Felderhoff-Müser, Ursula
    Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury
    In: Brain, Behavior and Immunity, Vol. 60, 2017, pp. 220 – 232
    DOI (Open Access)
  • Engels, Jonas; Elting, Natalie; Braun, Lisa; Bendix, Ivo; Herz, Josephine; Felderhoff-Müser, Ursula; Dzietko, Mark
    Sildenafil Enhances Quantity of Immature Neurons and Promotes Functional Recovery in the Developing Ischemic Mouse Brain
    In: Developmental Neuroscience, Vol. 39, 2017, Nr. 1-4, pp. 287 – 297
    DOI
  • Serdar, Meray; Herz, Josephine; Kempe, Karina; Lumpe, Katharina; Reinboth, Barbara S.; Sizonenko, Stéphane V.; Hou, Xinlin; Herrmann, Ralf; Hadamitzky, Martin; Heumann, Rolf; Hansen, Wiebke; Sifringer, Marco; van de Looij, Yohan; Felderhoff-Müser, Ursula; Bendix, Ivo
    Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia
    In: Brain, Behavior and Immunity, Vol. 52, 2016, pp. 106 – 119
    DOI (Open Access)
  • Herz, Josephine; Sabellek, Pascal; Lane, Thomas E; Gunzer, Matthias; Hermann, Dirk M.; Döppner, Thorsten R.
    Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice
    In: Stroke, Vol. 46, 2015, Nr. 10, pp. 2916 – 2925
    DOI (Open Access)
  • Mossakowski, Agata A.; Pohlan, Julian; Bremer, Daniel; Lindquist, Randall; Millward, Jason M.; Bock, Markus; Pollok, Karolin; Mothes, Ronja; Viohl, Leonard; Radbruch, Moritz; Gerhard, Jenny; Bellmann-Strobl, Judith; Behrens, Janina; Infante-Duarte, Carmen; Mähler, Anja; Boschmann, Michael; Rinnenthal, Jan Leo; Füchtemeier, Martina; Herz, Josephine; Pache, Florence C.; Bardua, Markus; Priller, Josef; Hauser, Anja E.; Paul, Friedemann; Niesner, Raluca; Radbruch, Helena
    Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation
    In: Acta Neuropathologica, Vol. 130, 2015, Nr. 6, pp. 799 – 814
    DOI (Open Access)
  • Neumann, Jens; Riek-Burchardt, Monika; Herz, Josephine; Döppner, Thorsten R.; König, Rebecca; Hütten, Heiko; Etemire, Eloho; Männ, Linda; Klingberg, Anika; Fischer, Thomas; Görtler, Michael W; Heinze, Hans-Jochen; Reichardt, Peter; Schraven, Burkhart; Hermann, Dirk M.; Reymann, Klaus G; Gunzer, Matthias
    Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke
    In: Acta Neuropathologica, Vol. 129, 2015, Nr. 2, pp. 259 – 277
    DOI
  • Schulze-Topphoff, U.; Prat, A.; Prozorovski, T.; Siffrin, V.; Paterka, M.; Herz, Josephine; Bendix, Ivo; Ifergan, I.; Schadock, I.; Mori, M. A.; Van Horssen, J.; Schröter, F.; Smorodchenko, A.; Han, M. H.; Bader, M.; Steinman, L.; Aktas, O.; Zipp, F.
    Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system
    In: Nature Medicine, Vol. 15, 2009, Nr. 7, pp. 788 – 793
    DOI