ZMB Member Erich Gulbins
ZMB Member
Erich Gulbins
Next ZMB-Member
Prof. Dr. Erich Gulbins
Director of:
Department of Molecular BiologyUniversity Hospital Essen
Hufelandstraße 55
45122 Essen
- +49 201 723 3118
- Website
- Selected Publications
- Publication Metrics
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- ZMB Research Program
Oncology
Research Overview
- Regulation and function of sphingolipids in bacterial infections, in particular pneumonia
1.1. Role of ceramide and sphingosine in cystic fibrosis
1.2. Molecular mechanisms of anti-bacterial effects of sphingosine
1.3. Development of novel treatments of pneumonia with Pseudomonas aeruginosa and Staphylococcus aureus
1.4. Regulation and function of sphingolipids in systemic infections with S. aureus and mycobacteria. - Sphingolipids in tumor therapy, with a focus on the regulation and function of sphingolipids in the immune system of the tumor host.
- Regulation and function of acid sphingomyelinase/ceramide in auto-immune disorders, in particular multiple sclerosis.
- The acid sphingomyelinase-ceramide-acid ceramidase axis as target of antidepressants. Role of this system in the pathogenesis and treatment of major depressive disorder.
- Targeting the mitochondrial Kv1.3 channel with novel specific inhibitors to treat cancer.
Selected Publications
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Comorbid medical conditions are a key factor to understand the relationship between psychiatric disorders and COVID-19-related mortality : Results from 49,089 COVID-19 inpatientsIn: Molecular Psychiatry (2021) in press
ISSN: 1359-4184; 1476-5578Online Full Text: dx.doi.org/ (Open Access) -
Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defectsIn: Molecular Psychiatry Vol. 26 (2021) Nr. 12, pp. 7403 - 7416
ISSN: 1476-5578; 1359-4184Online Full Text: dx.doi.org/ (Open Access) -
Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19 : Current evidence and potential mechanismsIn: Molecular Psychiatry Vol. 26 (2021) Nr. 12, pp. 7098 - 7099
ISSN: 1476-5578; 1359-4184Online Full Text: dx.doi.org/ (Open Access) -
The acid sphingomyelinase/ceramide system in COVID-19In: Molecular Psychiatry (2021) in press
ISSN: 1359-4184; 1476-5578Online Full Text: dx.doi.org/ (Open Access) -
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe diseaseIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 1338
ISSN: 2041-1723Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial CellsIn: Cell Reports Medicine Vol. 1 (2020) Nr. 8, pp. 100142
ISSN: 2666-3791Online Full Text: dx.doi.org/ (Open Access) -
Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic FibrosisIn: American Journal of Respiratory and Critical Care Medicine Vol. 202 (2020) Nr. 8, pp. 1133 - 1145
ISSN: 1535-4970; 0003-0805; 1073-449XOnline Full Text: dx.doi.org/ (Open Access) -
Specific inhibition of the NLRP3 inflammasome as an antiinflammatory strategy in cystic fibrosisIn: American Journal of Respiratory and Critical Care Medicine Vol. 200 (2019) Nr. 11, pp. 1381 - 1391
ISSN: 1073-449X; 1535-4970; 0003-0805Online Full Text: dx.doi.org/ -
Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramideIn: Molecular Psychiatry Vol. 23 (2018) pp. 2324 - 2346
ISSN: 1476-5578; 1359-4184Online Full Text: dx.doi.org/ (Open Access) -
Antidepressants regulate autophagy by targeting acid sphingomyelinaseIn: Molecular Psychiatry Vol. 23 (2018) Nr. 12, pp. 2251
ISSN: 1359-4184; 1476-5578Online Full Text: dx.doi.org/ (Open Access) -
Sphingolipids as targets for inhalation treatment of cystic fibrosisIn: Advanced Drug Delivery Reviews Vol. 133 (2018) pp. 66 - 75
ISSN: 1872-8294; 0169-409XOnline Full Text: dx.doi.org/ -
Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung InflammationIn: Annals of Surgery Vol. 265 (2017) Nr. 1, pp. 218 - 226
ISSN: 1528-1140; 0003-4932Online Full Text: dx.doi.org/ -
Direct pharmacological targeting of a mitochondrial ion channel selectively kills tumor cells in vivoIn: Cancer Cell Vol. 31 (2017) Nr. 4, pp. 516 - 531.e10
ISSN: 1535-6108; 1878-3686Online Full Text: dx.doi.org/ (Open Access) -
Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial functionIn: Nature Communications Vol. 8 (2017) pp. 480
ISSN: 2041-1723Online Full Text: dx.doi.org/ (Open Access) -
Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasisIn: Acta Neuropathologica Vol. 133 (2017) Nr. 3, pp. 463 - 483
ISSN: 1432-0533; 0001-6322Online Full Text: dx.doi.org/ (Open Access) -
β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial InfectionsIn: Cell Host & Microbe Vol. 21 (2017) Nr. 6, pp. 707 - 718.e8
ISSN: 1931-3128; 1934-6069Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphateIn: Journal of Hepatology Vol. 64 (2016) Nr. 1, pp. 60 - 68
ISSN: 1600-0641Online Full Text: dx.doi.org/ Online Full Text (Open Access) -
Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in miceIn: Nature Biotechnology Vol. 33 (2015) Nr. 1, pp. 81 - 88
ISSN: 1546-1696Online Full Text: dx.doi.org/ -
Regulation of hematogenous tumor metastasis by acid sphingomyelinaseIn: EMBO Molecular Medicine Vol. 7 (2015) Nr. 6, pp. 714 - 734
ISSN: 1757-4684; 1757-4676Online Full Text: dx.doi.org/ (Open Access) -
Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosaIn: EMBO Molecular Medicine Vol. 6 (2014) Nr. 9, pp. 1205 - 1214
ISSN: 1757-4684; 1757-4676Online Full Text: dx.doi.org/ (Open Access) -
Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugsIn: Nature Medicine Vol. 19 (2013) Nr. 7, pp. 934 - 938
ISSN: 1546-170X; 1078-8956Online Full Text: dx.doi.org/ -
Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemiaIn: Leukemia Vol. 27 (2013) Nr. 8, pp. 1782 - 1785
ISSN: 0887-6924; 1476-5551Online Full Text: dx.doi.org/ -
It takes a CAD to kill a tumor cell with a LMPIn: Cancer Cell Vol. 24 (2013) Nr. 3, pp. 279 - 281
ISSN: 1535-6108; 1878-3686Online Full Text: dx.doi.org/ (Open Access) -
Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cellsIn: EMBO Molecular Medicine Vol. 4 (2012) Nr. 7, pp. 577 - 593
ISSN: 1757-4684; 1757-4676Online Full Text: dx.doi.org/ (Open Access) -
Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infectionsIn: Nature Medicine Vol. 17 (2011) Nr. 3, pp. 341 - 346
ISSN: 1546-170X; 1078-8956Online Full Text: dx.doi.org/ -
Lipids control mucus production in cystic fibrosisIn: Nature Medicine Vol. 16 (2010) Nr. 3, pp. 267 - 268
ISSN: 1546-170X; 1078-8956Online Full Text: dx.doi.org/ -
Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosisIn: Nature Medicine Vol. 14 (2008) Nr. 4, pp. 382 - 391
ISSN: 1546-170X; 1078-8956Online Full Text: dx.doi.org/ (Open Access)