ZMB Member Erich Gulbins

ZMB Member
Erich Gulbins

Next ZMB-Member
Erich Gulbins portrait
© E. Gulbins

Prof. Dr. Erich Gulbins

University Hospital Essen
Hufelandstraße 55
45122 Essen

Research Overview

  1. Regulation and function of sphingolipids in bacterial infections, in particular pneumonia
    1.1. Role of ceramide and sphingosine in cystic fibrosis
    1.2. Molecular mechanisms of anti-bacterial effects of sphingosine
    1.3. Development of novel treatments of pneumonia with Pseudomonas aeruginosa and Staphylococcus aureus
    1.4. Regulation and function of sphingolipids in systemic infections with S. aureus and mycobacteria.
  2. Sphingolipids in tumor therapy, with a focus on the regulation and function of sphingolipids in the immune system of the tumor host.
  3. Regulation and function of acid sphingomyelinase/ceramide in auto-immune disorders, in particular multiple sclerosis.
  4. The acid sphingomyelinase-ceramide-acid ceramidase axis as target of antidepressants. Role of this system in the pathogenesis and treatment of major depressive disorder.
  5. Targeting the mitochondrial Kv1.3 channel with novel specific inhibitors to treat cancer.

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Selected Publications

    Journal articles

  • Kalinichenko, Liubov S.; Mühle, Christiane; Jia, Tianye; Anderheiden, Felix; Datz, Maria; Eberle, Anna-Lisa; Eulenburg, Volker; Granzow, Jonas; Hofer, Martin; Hohenschild, Julia; Huber, Sabine E.; Kämpf, Stefanie; Kogias, Georgios; Lacatusu, Laura; Lugmair, Charlotte; Taku, Stephen Mbu; Meixner, Doris; Tesch, Nina; Praetner, Marc; Rhein, Cosima; Sauer, Christina; Scholz, Jessica; Ulrich, Franziska; Valenta, Florian; Weigand, Esther; Werner, Markus; Tay, Nicole; Mc Veigh, Conor J.; Haase, Jana; Wang, An-Li; Abdel-Hafiz, Laila; Huston, Joseph P.; Smaga, Irena; Frankowska, Malgorzata; Filip, Malgorzata; Lourdusamy, Anbarasu; Kirchner, Philipp; Ekici, Arif B.; Marx, Lena M.; Suresh, Neeraja Puliparambil; Frischknecht, Renato; Fejtova, Anna; Saied, Essa M.; Arenz, Christoph; Bozec, Aline; Wank, Isabel; Kreitz, Silke; Hess, Andreas; Bäuerle, Tobias; Ledesma, Maria Dolores; Mitroi, Daniel N.; Miranda, André M.; Oliveira, Tiago G.; Gulbins, Erich; Lenz, Bernd; Schumann, Gunter; Kornhuber, Johannes; Müller, Christian P.
    Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects
    In: Molecular Psychiatry (2021)
    ISSN: 1476-5578; 1359-4184
  • Hoertel, Nicolas; Sánchez-Rico, Marina; Cougoule, Céline; Gulbins, Erich; Kornhuber, Johannes; Carpinteiro, Alexander; Becker, Katrin Anne; Reiersen, Angela M.; Lenze, Eric J.; Seftel, David; Lemogne, Cédric; Limosin, Frédéric
    Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19 : Current evidence and potential mechanisms
    In: Molecular Psychiatry (2021) in press
    ISSN: 1476-5578; 1359-4184
  • Kornhuber, Johannes; Hoertel, Nicolas; Gulbins, Erich
    The acid sphingomyelinase/ceramide system in COVID-19
    In: Molecular Psychiatry (2021) in press
    ISSN: 1359-4184; 1476-5578
  • Lang, Judith; Bohn, Patrick; Bhat, Hilal; Jastrow, Holger; Walkenfort, Bernd; Cansiz, Feyza; Fink, Julian; Bauer, Michael; Olszewski, Dominik; Ramos-Nascimento, Ana; Duhan, Vikas; Friedrich, Sarah-Kim; Becker-Flegler, Katrin; Krawczyk, Adalbert; Edwards, Michael J.; Burchert, Andreas; Huber, Magdalena; Friebus-Kardash, Justa; Göthert, Joachim Rudolf; Hardt, Cornelia; Probst, Hans Christian; Schumacher, Fabian; Köhrer, Karl; Kleuser, Burkhard; Babiychuk, Eduard B.; Sodeik, Beate; Seibel, Jürgen; Greber, Urs F.; Lang, Philipp A.; Gulbins, Erich; Lang, Karl S.
    Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 1338
    ISSN: 2041-1723
  • Carpinteiro, Alexander; Edwards, Michael J.; Hoffmann, Markus; Kochs, Georg; Gripp, Barbara; Weigang, Sebastian; Adams, Constantin; Carpinteiro, Elisa; Gulbins, Anne; Keitsch, Simone; Sehl, Carolin; Soddemann, Matthias; Wilker, Barbara; Kamler, Markus; Bertsch, Thomas; Lang, Karl S.; Patel, Sameer; Wilson, Gregory C.; Walter, Silke; Hengel, Hartmut; Pöhlmann, Stefan; Lang, Philipp A.; Kornhuber, Johannes; Becker, Katrin; Ahmad, Syed A.; Fassbender, Klaus; Gulbins, Erich
    Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells
    In: Cell Reports Medicine Vol. 1 (2020) Nr. 8, pp. 100142
    ISSN: 2666-3791
  • Gardner, Aaron I.; Haq, Iram J.; Simpson, A. John; Becker, Katrin; Gallagher, John; Saint-Criq, Vinciane; Verdon, Bernard; Mavin, Emily; Trigg, Alexandra; Gray, Michael A.; Koulman, Albert; McDonnell, Melissa J.; Fisher, Andrew J.; Kramer, Elizabeth L.; Clancy, John P.; Ward, Christopher; Schuchman, Edward H.; Gulbins, Erich; Brodlie, Malcolm
    Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis
    In: American Journal of Respiratory and Critical Care Medicine Vol. 202 (2020) Nr. 8, pp. 1133 - 1145
    ISSN: 1535-4970; 0003-0805; 1073-449X
  • Verhaegh, Rabea; Becker, Katrin Anne; Edwards, Michael J.; Gulbins, Erich
    Sphingosine kills bacteria by binding to cardiolipin
    In: Journal of Biological Chemistry Vol. 295 (2020) Nr. 22, pp. 7686 - 7696
    ISSN: 1083-351X; 0021-9258
  • McElvaney, Oliver J.; Zaslona, Zbigniew; Becker-Flegler, Katrin; Palsson-McDermott, Eva M.; Boland, Fiona; Gunaratnam, Cedric; Gulbins, Erich; O'Neill, Luke A.; Reeves, Emer P.; McElvaney, Noel G.
    Specific inhibition of the NLRP3 inflammasome as an antiinflammatory strategy in cystic fibrosis
    In: American Journal of Respiratory and Critical Care Medicine Vol. 200 (2019) Nr. 11, pp. 1381 - 1391
    ISSN: 1073-449X; 1535-4970; 0003-0805
  • Gulbins, Anne; Schumacher, Fabian; Becker, Katrin Anne; Wilker, Barbara; Soddemann, Matthias; Boldrin, Francesco; Müller, Christian P.; Edwards, Michael J.; Goodman, Michael; Caldwell, Charles C.; Kleuser, Burkhard; Kornhuber, Johannes; Szabo, Ildiko; Gulbins, Erich
    Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide
    In: Molecular Psychiatry Vol. 23 (2018) pp. 2324 - 2346
    ISSN: 1476-5578; 1359-4184
  • Gulbins, Anne; Schumacher, Fabian; Becker, Katrin Anne; Wilker, Barbara; Soddemann, Matthias; Boldrin, Francesco; Müller, Christian P.; Edwards, Michael J.; Goodman, Michael; Caldwell, Charles C.; Kleuser, Burkhard; Kornhuber, Johannes; Szabo, Ildiko; Gulbins, Erich
    Antidepressants regulate autophagy by targeting acid sphingomyelinase
    In: Molecular Psychiatry Vol. 23 (2018) Nr. 12, pp. 2251
    ISSN: 1359-4184; 1476-5578
  • Becker-Flegler, Katrin; Riethmüller, Joachim; Seitz, Aaron P.; Gardner, Aaron; Boudreau, Ryan; Kamler, Markus; Kleuser, Burkhard; Schuchman, Edward; Caldwell, Charles C.; Edwards, Michael J.; Grassmé, Heike; Brodlie, Malcolm; Gulbins, Erich
    Sphingolipids as targets for inhalation treatment of cystic fibrosis
    In: Advanced Drug Delivery Reviews Vol. 133 (2018) pp. 66 - 75
    ISSN: 1872-8294; 0169-409X
  • Hoehn, Richard S; Jernigan, Peter L; Japtok, Lukasz; Chang, Alex L; Midura, Emily F; Caldwell, Charles C; Kleuser, Burkhard; Lentsch, Alex B; Edwards, Michael J; Gulbins, Erich; Pritts, Timothy A
    Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation
    In: Annals of Surgery Vol. 265 (2017) Nr. 1, pp. 218 - 226
    ISSN: 0003-4932; 1528-1140
  • Leanza, Luigi; Romio, Matteo; Becker-Flegler, Katrin; Azzolini, Michele; Trentin, Livio; Managò, Antonella; Venturini, Elisa; Zaccagnino, Angela; Mattarei, Andrea; Carraretto, Luca; Urbani, Andrea; Kadow, Stephanie; Biasutto, Lucia; Martini, Veronica; Severin, Filippo; Peruzzo, Roberta; Trimarco, Valentina; Egberts, Jan-Hendrik; Hauser, Charlotte; Visentin, Andrea; Semenzato, Gianpietro; Kalthoff, Holger; Zoratti, Mario; Gulbins, Erich; Paradisi, Cristina; Szabo, Ildiko
    Direct pharmacological targeting of a mitochondrial ion channel selectively kills tumor cells in vivo
    In: Cancer Cell Vol. 31 (2017) Nr. 4, pp. 516 - 531.e10
    ISSN: 1535-6108; 1878-3686
  • Item, Flurin; Wueest, Stephan; Lemos, Vera; Stein, Sokrates; Lucchini, Fabrizio C.; Denzler, Rémy; Fisser, Muriel C.; Challa, Tenagne D.; Pirinen, Eija; Kim, Youngsoo; Hemmi, Silvio; Gulbins, Erich; Gross, Atan; O'Reilly, Lorraine A.; Stoffel, Markus; Auwerx, Johan; Konrad, Daniel
    Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
    In: Nature Communications Vol. 8 (2017) pp. 480
    ISSN: 2041-1723
  • Müller, Christian P.; Kalinichenko, Liubov S.; Tiesel, Jens; Witt, Matthias; Stöckl, Thomas; Sprenger, Eva; Fuchser, Jens; Beckmann, Janine; Praetner, Marc; Huber, Sabine E.; Amato, Davide; Mühle, Christiane; Büttner, Christian; Ekici, Arif B.; Smaga, Irena; Pomierny-Chamiolo, Lucyna; Pomierny, Bartosz; Filip, Malgorzata; Eulenburg, Volker; Gulbins, Erich; Lourdusamy, Anbarasu; Reichel, Martin; Kornhuber, Johannes
    Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis
    In: Acta Neuropathologica Vol. 133 (2017) Nr. 3, pp. 463 - 483
    ISSN: 1432-0533; 0001-6322
  • Grassmé, Heike; Henry, Brian; Ziobro, Regan; Becker, Katrin Anne; Riethmüller, Joachim; Gardner, Aaron; Seitz, Aaron P.; Steinmann, Jörg; Lang, Stephan; Ward, Christopher; Schuchman, Edward H.; Caldwell, Charles C.; Kamler, Markus; Edwards, Michael J.; Brodlie, Malcolm; Gulbins, Erich
    β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections
    In: Cell Host & Microbe Vol. 21 (2017) Nr. 6, pp. 707 - 718.e8
    ISSN: 1931-3128; 1934-6069
  • Nojima, Hiroyuki; Gulbins, Erich; Kleuser, Burkhard; Kleuser, Burkhard; Japtok, Lukasz; Freeman, Christopher M.; Schuster, Marc
    Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate
    In: Journal of Hepatology Vol. 64 (2016) Nr. 1, pp. 60 - 68
    ISSN: 1600-0641
  • Henry, Brian D; Babiychuk, Eduard B; Draeger, Annette; Kadioglu, Aras; Gulbins, Erich; Scherag, Andre; Wolfmeier, Heidi; Luginbühl, Miriam; Japtok, Lukasz; Kleuser, Burkhard; Steinmann, Jörg; Mühlemann, Kathrin; Edwards, Michael J; Ziobro, Regan; Bricio-Moreno, Laura; Gore, Suzanna; Becker-Flegler, Katrin; Neill, Daniel R
    Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice
    In: Nature Biotechnology Vol. 33 (2015) Nr. 1, pp. 81 - 88
    ISSN: 1546-1696
  • Carpinteiro, Alexander; Becker-Flegler, Katrin; Japtok, Lukasz; Hessler, Gabriele; Keitsch, Simone; Požgajovà, Miroslava; Schmid, Kurt Werner; Adams, Constantin; Müller, Stefan; Kleuser, Burkhard; Edwards, Michael J.; Grassmé, Heike; Helfrich, Iris; Gulbins, Erich
    Regulation of hematogenous tumor metastasis by acid sphingomyelinase
    In: EMBO Molecular Medicine Vol. 7 (2015) Nr. 6, pp. 714 - 734
    ISSN: 1757-4684
  • Pewzner-Jung, Yael; Tavakoli Tabazavareh, Shaghayegh; Grassmé, Heike; Becker, Katrin A.; Japtok, Lukasz; Steinmann, Jörg; Joseph, Tammar; Lang, Stephan; Tuemmler, Burkhard; Schuchman, Edward H.; Lentsch, Alex B.; Kleuser, Burkhard P.; Edwards, Michael J. R.; Futerman, Anthony H.; Gulbins, Erich
    Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa
    In: EMBO Molecular Medicine Vol. 6 (2014) Nr. 9, pp. 1205 - 1214
    ISSN: 1757-4676; 1757-4684
  • Gulbins, Erich; Palmada, Monica; Reichel, Martin; Lüth, Anja; Böhmer, Christoph; Amato, Davide; Müller, Christian P.; Tischbirek, Carsten H.; Groemer, Teja W.; Tabatabai, Ghazaleh; Becker-Flegler, Katrin; Tripal, Philipp; Staedtler, Sven; Ackermann, Teresa F.; Van Brederode, Johannes; Alzheimer, Christian; Weller, Michael; Lang, Undine E.; Kleuser, Burkhard; Grassmé, Heike; Kornhuber, Johannes
    Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs
    In: Nature Medicine Vol. 19 (2013) Nr. 7, pp. 934 - 938
    ISSN: 1546-170X; 1078-8956
  • Leanza, L; Trentin, L; Becker-Flegler, Katrin; Frezzato, F; Zoratti, M; Semenzato, G; Gulbins, Erich; Szabo, I
    Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemia
    In: Leukemia Vol. 27 (2013) Nr. 8, pp. 1782 - 1785
    ISSN: 0887-6924; 1476-5551
  • Gulbins, Erich; Kolesnick, Richard N
    It takes a CAD to kill a tumor cell with a LMP
    In: Cancer Cell Vol. 24 (2013) Nr. 3, pp. 279 - 281
    ISSN: 1535-6108; 1878-3686
  • Leanza, Luigi; Henry, Brian; Sassi, Nicola; Zoratti, Mario; Chandy, K. George; Gulbins, Erich; Szabò, Ildikò
    Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells
    In: EMBO Molecular Medicine Vol. 4 (2012) Nr. 7, pp. 577 - 593
    ISSN: 1757-4676; 1757-4684
  • Zhang, Yang; Li, Xiang; Carpinteiro, Alexander; Goettel, Jeremy A.; Soddemann, Matthias; Gulbins, Erich
    Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections
    In: Nature Medicine Vol. 17 (2011) Nr. 3, pp. 341 - 346
    ISSN: 1546-170X; 1078-8956
  • Gulbins, Erich
    Lipids control mucus production in cystic fibrosis
    In: Nature Medicine Vol. 16 (2010) Nr. 3, pp. 267 - 268
    ISSN: 1546-170X; 1078-8956
  • Perrotta, Cristiana; Bizzozero, Laura; Cazzato, Denise; Morlacchi, Sara; Assi, Emma; Simbari, Fabio; Zhang, Yang; Gulbins, Erich; Bassi, Maria Teresa; Rosa, Patrizia; Clementi, Emilio
    Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function
    In: Journal of Biological Chemistry Vol. 285 (2010) Nr. 51, pp. 40240 - 40251
    ISSN: 0021-9258; 1083-351X
  • Teichgräber, Volker; Ulrich, Martina; Endlich, Nicole; Riethmüller, Joachim; Wilker, Barbara; De Oliveira-Munding, Cheyla Conceição; Van Heeckeren, Anna M.; Barr, Mark L.; Von Kürthy, Gabriele; Schmid, Kurt Werner; Weller, Michael; Tümmler, Burkhard; Lang, Florian; Grassme, Heike; Döring, Gerd; Gulbins, Erich
    Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis
    In: Nature Medicine Vol. 14 (2008) Nr. 4, pp. 382 - 391
    ISSN: 1078-8956; 1546-170X
  • Teichgräber, Volker; Ulrich, Martina; Endlich, NIcole; Döring, Gerd; Grassme, Heike; Riethmüller, Joachim; Gulbins, Erich; Weller, Michael; Lang, Florian; Tümmler, Burkhard; Wilker, Barbara; Schmid, Kurt Werner; De Oliveira-Munding, Cheyla Conceição; van Heeckeren, Anna M.; Barr, Mark L.; von Kürthy, Gabriele
    Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis.
    In: Nature Medicine Vol. 4 (2008) Nr. 14, pp. 382 - 391
    ISSN: 1546-170X; 1078-8956