Publikationen/Publications

Selected publications

​2026-2020

1. Parrasia S, Paoli C, Varanita T, Brillo V, Abdel-Salam MAL, Ongaro A, Honisch C, Angi B, Bachmann M, Bergamin F, Corbo V, Fiorini E, Rossa A, Bossio G, Gulbins E, Carrer A, Zoratti M, Mattarei A, Ruzza P, Biasutto L, Szabo I. Tumor-specific targeting of a mitochondrial Kv1.3 channel inhibitor through conjugation to gastrin/cholecystokinin B receptor ligand strongly reduces pancreatic ductal adenocarcinoma in orthotopic models. Pharmacol Res 2026 Mar;225:108150. Pharmacol Res. 2026 Feb 20;225:108150. doi: 10.1016/j.phrs.2026.108150
2. Angi B, Varanita T, Puthenparampil M, Scattolini V, Donadon M, Tavakoli M, Favero M, El Boustani M, Soddemann M, Biasutto L, Arcidiacono D, Ongaro A, Mattarei A, Trentin L, Wilson G, Gulbins E, Gallo P, Szabo I. Selective inhibition of mitochondrial Kv1.3 prevents and alleviates multiple sclerosis in vivo. EMBO Mol Med 2025 Nov;17(11):2901-2931. EMBO Mol Med. 2025 Sep 29;17(11):2901-2931. doi: 10.1038/s44321-025-00307-2.
3. Wu Y, Schnitker F, Liu Y, Keitsch S, Caicci F, Schumacher F, Riehle A, Pollmeier B, Kehrmann J, Kleuser B, Kamler M, Szabo I, Grassmé H, Gulbins E. Sphingosine kills Mycobacteria and suppresses mycobacterial lung infections. J Mol Med (Berl) 2025 Mar 28. doi: 10.1007/s00109-025-02534-z. J Mol Med (Berl). 2025 Mar 28;103(5):547-558. doi: 10.1007/s00109-025-02534-z.
4. Grassmé H, Wilson GC, Wu Y, Hasenberg M, Keitsch S, Caicci F, Edwards MJ, Szabo I, Gulbins E. Sphingosine-mediated death of Pseudomonas aeruginosa involves degradation of cardiolipin by the maintenance of outer lipid asymmetry system. Infect Immun 2025 Apr 8;93:e0059124. Infect Immun. 2025 Mar 10;93(4):e0059124. doi: 10.1128/iai.00591-24.
5. Wilson GC, Patel SH, Wang J, Xu K, Turner KM, Becker KA, Carpinteiro A, Szabo I, Ahmad SA, Gulbins E.  Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma. J Mol Med (Berl) 2023;101:891-903. J Mol Med (Berl). 2023 May 29;101(7):891-903. doi: 10.1007/s00109-023-02331-6.
6. Schumacher F, Carpinteiro A, Edwards MJ, Wilson GC, Keitsch S, Soddemann M, Wilker B, Kleuser B, Becker KA, Müller CP, Kornhuber J, Gulbins E. Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma. J Mol Med (Berl) 2022;100:1493-1508. J Mol Med (Berl). 2022 Aug 31;100(10):1493-1508. doi: 10.1007/s00109-022-02250-y.
7. Schumacher F, Edwards MJ, Mühle C, Carpinteiro A, Wilson GC, Wilker B, Soddemann M, Keitsch S, Scherbaum N, Müller BW, Lang UE, Linnemann C, Kleuser B, Müller CP, Kornhuber J, Gulbins E. Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice. J Biol Chem 2022;298:102185.  J Biol Chem. 2022 Jun 24;298(8):102185. doi: 10.1016/j.jbc.2022.102185.
8. Gardner AI, Wu Y, Verhaegh R, Liu Y, Wilker B, Soddemann M, Keitsch S, Edwards MJ, Haq IJ, Kamler M, Becker KA, Brodlie M, Gulbins E. Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis. J Biol Chem 2021;296:100650. J Biol Chem. 2021 Apr 9;296:100650. doi: 10.1016/j.jbc.2021.100650.
9. Carpinteiro A, Edwards MJ, Hoffmann M, Kochs G, Gripp B, Weigang S, Adams C, Carpinteiro E, Gulbins A, Keitsch S, Sehl C, Soddemann M, Wilker B, Kamler M, Bertsch T, Lang KS, Patel S, Wilson GC, Walter S, Hengel H, Pöhlmann S, Lang PA, Kornhuber J, Becker KA, Ahmad SA, Fassbender K, Gulbins E. Pharmacological inhibition of acid sphingomyelinase prevents uptake of SARS-CoV-2 by epithelial cells. CELL Rep Med 2020;1:100142. Cell Rep Med. 2020 Oct 29;1(8):100142. doi: 10.1016/j.xcrm.2020.100142.
10. Gardner AI, Haq IJ, Simpson AJ, Becker KA, Gallagher J, Saint-Criq V, Verdon B, Mavin E, Trigg A, Gray MA, Koulman A, McDonnell MJ, Fisher AJ, Kramer EL, Clancy JP, Ward C, Schuchman EH, Gulbins E, Brodlie M. Recombinant acid ceramidase reduces inflammation and infection in cystic fibrosis. Am J Respir Crit Care Med 2020;202:1133-1145. Am J Respir Crit Care Med. 2020 Oct 15;202(8):1133-1145. doi: 10.1164/rccm.202001-0180OC.
11. Verhaegh R, Becker KA, Edwards MJ, Gulbins E. Sphingosine kills bacteria by binding to cardiolipin. J Biol Chem 2020;295:7686-96. J Biol Chem. 2020 Apr 23;295(22):7686-7696. doi: 10.1074/jbc.RA119.012325.
12. Lang J, Bohn P, Bhat H, Jastrow H, Walkenfort B, Cansiz F, Fink J, Bauer M, Olszewski D, Ramos-Nascimento A, Duhan V, Friedrich SK, Becker KA, Krawczyk A, Edwards MJ, Burchert A, Huber M, Friebus-Kardash J, Göthert JR, Hardt C, Probst HC, Schumacher F, Köhrer K, Kleuser B, Babiychuk EB, Sodeik B, Seibel J, Greber UF, Lang PA*, Gulbins E*, Lang KS*. Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease. Nat Commun 2020;11:1338 (* shared last authorship) Nat Commun. 2020 Mar 12;11(1):1338. doi: 10.1038/s41467-020-15072-8.

2019-2015

13. Walter S, Gulbins E, Halmer R, Jahromi NH, Becker KA, Schottek A, Blatti C, Davies L, Schnoeder L, Bertsch T, Engelhardt B, Fassbender K. Pharmacological inhibition of acid sphingomyelinase ameliorates experimental autoimmune encephalomyelitis. Neurosignals 2019;27:20-31. Neurosignals. 2019;27(S1):20-31. doi: 10.33594/000000183.
14. Gulbins A, Schumacher F, Becker KA, Wilker B, Soddemann M, Boldrin F, Müller CP, Edwards MJ, Goodman M, Caldwell CC, Kleuser B, Kornhuber J, Szabo I, Gulbins E. Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide. Mol Psychiatry 2018;23:2324-46. Mol Psychiatry. 2018 Jul 23;23(12):2324-2346. doi: 10.1038/s41380-018-0090-9.
15. Becker KA, Halmer R, Davies L, Henry BD, Ziobro-Henry R, Decker Y, Liu Y, Gulbins E, Fassbender K, Walter S. Blockade of experimental multiple sclerosis by inhibition of the acid sphingomyelinase/ceramide system. Neurosignals 2017;25:88-97.
    Neurosignals. 2017 Nov 6;25(1):88-97. doi: 10.1159/000484621. 
16. Grassmé H, Henry B, Ziobro R, Becker KA, Riethmüller J, Gardner A, Seitz AP, Steinmann J, Lang S, Ward C, Schuchman EH, Caldwell CC, Kamler M, Edwards MJ, Brodlie M, Gulbins E. β1-Integrin accumulates in cystic fibrosis luminal airway epithelial membranes and decreases sphingosine, promoting bacterial infections. Cell Host Microbe 2017;21:707-18. Cell Host Microbe. 2017 May 25;21(6):707-718.e8. doi: 10.1016/j.chom.2017.05.001.
17. Leanza L, Romio M, Becker KA, Azzolini M, Trentin L, Managò A, Venturini E, Zaccagnino A, Mattarei A, Carraretto L, Urbani A, Kadow S, Biasutto L, Martini V, Severin F, Peruzzo R, Trimarco V, Egberts JH, Hauser C, Visentin A, Semenzato G, Kalthoff H, Zoratti M, Gulbins E*, Paradisi C*, Szabo I*. Direct pharmacological targeting of a mitochondrial ion channel selectively kills tumor cells in vivo. Cancer Cell 2017;31:516-31. (*shared corresponding authorship). Cancer Cell. 2017 Apr 10;31(4):516-531.e10. doi: 10.1016/j.ccell.2017.03.003.
18. Nojima H, Freeman CM, Schuster RM, Japtok L, Kleuser B, Edwards MJ, Gulbins E, Lentsch AB. Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate. J Hepatol 2016;64:60-8. J Hepatol. Author manuscript. 2015 Aug 5;64(1):60-8. doi: 10.1016/j.jhep.2015.07.030.
19. Carpinteiro A, Becker KA, Japtok L, Hessler G, Keitsch S, Pozgajova M, Schmid KW, Adams C, Müller S, Kleuser B, Edwards MJ, Grassmé H, Helfrich I, Gulbins E. Regulation of hematogenous tumor metastasis by acid sphingomyelinase. EMBO Mol Med 2015;7:714-34. EMBO Mol Med. 2015 Jun;7(6):714-34. doi: 10.15252/emmm.201404571.
20. Henry BD*, Neill DR*, Becker KA*, Gore S, Bricio-Moreno L, Ziobro R, Edwards MJ, Mühlemann K, Steinmann J, Kleuser B, Japtok L, Luginbühl M, Wolfmeier, Scherag A, Gulbins E*, Kadioglu A*, Draeger A*, Babiychuk EB*. Biomimetic, toxin-sequestrating therapy for the treatment of severe invasive bacterial infections. Nat Biotechnol 2015;33:81-8. *Shared first authorship  and senior authorship.

2014 - earlier

21. Pewzner-Jung Y, Tavakoli Tabazavareh S, Grassmé H, Becker KA, Japtok L, Steinmann J, Joseph T, Lang S, Tuemmler B, Schuchman EH, Lentsch AB, Kleuser B, Edwards MJ, Futerman AH, Gulbins E. Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa. EMBO Mol Med 2014;6:1205-1. EMBO Mol Med. 2014 Sep;6(9):1205-14. doi: 10.15252/emmm.201404075.
22. Gulbins E, Palmada M, Reichel M, Lüth A, Böhmer C, Amato D, Müller CP, Tischbirek CH, Groemer TW, Tabatabai G, Becker KA, Tripal P, Staedtler S, Ackermann TF, v. Brederode J, Alzheimer C, Weller M, Lang UE, Kleuser B, Grassmé H, Kornhuber J. Acid sphingomyelinase/ceramide system mediates effects of antidepressant drugs. Nat Med 2013;19:934-8. Nat Med. 2013 Jun 16;19(7):934-8. doi: 10.1038/nm.3214.
23. Leanza L, Henry B, Sassi N, Zoratti M, Chandy KG, Gulbins E, Szabò I. Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells. EMBO Mol Med 2012;4:577-93. EMBO Mol Med. 2012 Apr 11;4(7):577-93. doi: 10.1002/emmm.201200235.
24. Zhang Y, Li X, Carpinteiro A, Goettel JA, Soddemann M, Gulbins E. Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections. Nat Med 2011;17:341-6. Nat Med. 2011 Feb 6;17(3):341-6. doi: 10.1038/nm.2296.
25. Avota E, Gulbins E, Schneider-Schaulies S. DC-SIGN mediated sphingomyelinase-activation and ceramide generation is essential for enhancement of viral uptake in dendritic cells. Plos Pathogens 2011;7:e1001290. PLoS Pathog. 2011 Feb 17;7(2):e1001290. doi: 10.1371/journal.ppat.1001290.
26. Szabo I, Bock J, Grassmé H, Soddemann M, Wilker B, Lang F, Zoratti M, Gulbins E. Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes. Proc Natl Acad Sci U S A 2008;105:14861-6. Proc Natl Acad Sci U S A. 2008 Sep 25;105(39):14861-6. doi: 10.1073/pnas.0804236105.
27. Teichgräber V, Ulrich M, Endlich N, Riethmüller J, Wilker B, De Oliveira-Munding CC, van Heeckeren AM, Barr ML, von Kürthy G, Schmid KW, Weller M, Tümmler B, Lang F, Grassmé H, Döring G, Gulbins E. Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis. Nat Med 2008;14:382-91. Nat Med. 2008 Mar 30;14(4):382-91. doi: 10.1038/nm1748.
28. Kornhuber J, Tripal P, Reichel M, Terfloth L, Bleich S, Wiltfang J, Gulbins E. Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. J Med Chem 2008;51:219-37. J Med Chem. 2007 Nov 21;51(2):219-37. doi: 10.1021/jm070524a.
29. Lang PA, Schenck M, Nicolay JP, Becker JU, Kempe DS, Lupescu A, Koka S, Eisele K, Klarl BA, Rübben H, Schmid KW, Mann K, Hildenbrand S, Hefter H, Huber SM, Wieder T, Erhardt A, Häussinger D, Gulbins E*, Lang F*. Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide. Nat Med 2007;13:164-70. (*shared corresponding authorship). Nat Med. 2007 Jan 28;13(2):164-70. doi: 10.1038/nm1539.
30. Göggel R, Winoto-Morbach S, Vielhaber G, Imai Y, Lindner K, Brade L, Brade H, Ehlers S, Slutsky AS, Schütze S, Gulbins E, Uhlig S. PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. Nat Med 2004;10:155-60. Nat Med. 2004 Jan 4;10(2):155-60. doi: 10.1038/nm977.
31. Grassmé H, Jendrossek V, Riehle A, von Kürthy G, Berger J, Schwarz H, Weller M, Kolesnick R, Gulbins E. Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts. Nat Med 2003;9:322-30. Nat Med. 2003 Feb 3;9(3):322-30. doi: 10.1038/nm823.
32. Grassmé H, Jekle A, Riehle A, Schwarz H, Berger J, Sandhoff K, Kolesnick R, Gulbins E. CD95 signaling via ceramide-rich membrane rafts. J Biol Chem 2001;276:20589-96. J Biol Chem. 2001 Mar 12;276(23):20589-96. doi: 10.1074/jbc.M101207200.
33. Grassmé H, Kirschnek S, Riethmueller J, Riehle A, von Kürthy G, Lang F, Weller M, Gulbins E. CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa. Science 2000;290:527-30. Science. 2000 Oct 20;290(5491):527-30. doi: 10.1126/science.290.5491.527.
34. *Grassmé H, *Gulbins E, Brenner B, Ferlinz K, Sandhoff K, Harzer K, Lang F, Meyer TF. Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells. Cell 1997;91:605-15. (*shared first authorship). Cell. 1997 Nov 28;91(5):605-15. doi: 10.1016/s0092-8674(00)80448-1.
35. Gulbins E, Szabo I, Baltzer K, Lang F. Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases. Proc Natl Acad Sci USA 1997;94:7661-6. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7661-6. doi: 10.1073/pnas.94.14.7661.
36. Gulbins E, Bissonnette R, Mahboubi A, Martin S, Nishioka W, Brunner T, Baier G, Baier-Bitterlich G, Byrd C, Lang F, Kolesnick R, Altman A, Green D. FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway. Immunity 1995;2:341-51. Immunity. 1995 Apr;2(4):341-51. doi: 10.1016/1074-7613(95)90142-6.
37. Gulbins E, Parekh N, Rauterberg EW, Schlottmann K, Steinhausen M. Cysteinyl leukotriene actions on the microcirculation of the normal and split hydronephrotic rat kidney. Eur J Clin Invest 1991;21:184-96. Eur J Clin Invest. 1991 Apr;21(2):184-96. doi: 10.1111/j.1365-2362.1991.tb01808.x.