ZMB Member Matthias Gunzer
ZMB Member
Matthias Gunzer
Next ZMB-Member
Prof. Dr. Matthias Gunzer
Director of:
Institute of Experimental Immunology & ImagingCenter of Medical Biotechnology (ZMB)
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen
University Hospital Essen
Hufelandstr. 55
45122 Essen
- +49 201 183 6640
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- Selected Publications
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- ZMB Research Program
Immunology, Infectious Diseases and Transplantation
Research Overview
The research interest of my group is to characterize the dynamics of immune cell behaviour, their motility and migratory pattern as well as formation of cell-cell interaction within the course of the immune response in vivo. My lab employs a wide range of specialized imaging technologies by which we investigate a number of projects how immune cells function in vivo in important organs such as the lymph node, the bone marrow, the brain and the lung.
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Selected Publications
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IL-10 sensing by lung interstitial macrophages prevents bacterial dysbiosis-driven pulmonary inflammation and maintains immune homeostasisIn: Immunity , Vol. 58 2025, Nr. 5, pp. 1306 – 1326.e7DOI (Open Access)
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msiFlow : automated workflows for reproducible and scalable multimodal mass spectrometry imaging and microscopy data analysisIn: Nature Communications , Vol. 16 2025, Nr. 1, 1065DOI (Open Access)
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Cranioencephalic functional lymphoid units in glioblastomaIn: Nature Medicine , Vol. 30 2024, Nr. 10, pp. 2947 – 2956DOI (Open Access)
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ComplexEye : a multi-lens array microscope for high-throughput embedded immune cell migration analysisIn: Nature Communications , Vol. 14 2023, Nr. 1, 8103DOI, Online Full Text (Open Access)
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Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell folliclesIn: PLoS Pathogens , Vol. 19 2023, Nr. 10, e1011725DOI (Open Access)
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Imaging innate immunity*In: Immunological Reviews , Vol. 306 2022, Nr. 1, pp. 293 – 303DOI (Open Access)
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The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injuryIn: Nature Communications , Vol. 13 2022, Nr. 1, 5786DOI (Open Access)
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Antibody-guided in vivo imaging of Aspergillus fumigatus lung infections during antifungal azole treatmentIn: Nature Communications , Vol. 12 2021, Nr. 1, pp. 1707DOI (Open Access)
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Neutrophils self-limit swarming to contain bacterial growth in vivoIn: Science , Vol. 372 2021, Nr. 6548DOI (Open Access)
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SOCS-1 inhibition of type i interferon restrains Staphylococcus aureus skin host defenseIn: PLoS Pathogens , Vol. 17 2021, Nr. 3, pp. 1009387DOI (Open Access)
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Durable and controlled depletion of neutrophils in miceIn: Nature Communications , Vol. 11 2020, pp. 2762DOI (Open Access)
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Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signalingIn: Nature Communications , Vol. 11 2020, Nr. 1, pp. 3547DOI (Open Access)
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Multicolor two-photon imaging of in vivo cellular pathophysiology upon influenza virus infection using the two-photon IMPRESSIn: Nature Protocols , Vol. 15 2020, pp. 1041 – 1065DOI (Open Access)
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Non-classical monocyte homing to the gut via α4β7 integrin mediates macrophage-dependent intestinal wound healingIn: Gut , Vol. 69 2020, pp. 252 – 263
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STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosisIn: Gut , Vol. 69 2020, Nr. 7, pp. 1269 – 1282
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A network of trans-cortical capillaries as mainstay for blood circulation in long bonesIn: Nature Metabolism , Vol. 1 2019, Nr. 2, pp. 236 – 250DOI (Open Access)
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Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal CancerIn: Immunity , Vol. 50 2019, Nr. 1, pp. 166 – 180.e7DOI (Open Access)
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Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and responseIn: Nature Communications , Vol. 10 2019, Nr. 1, pp. 2312DOI (Open Access)
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Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and MetastasisIn: Cancer Cell , Vol. 36 2019, Nr. 3, pp. 319 – 336.e7DOI (Open Access)
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Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell deathIn: Nature , Vol. 569 2019, Nr. 7755, pp. 236 – 240DOI (Open Access)
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Microglial cell loss after ischemic stroke favors brain neutrophil accumulationIn: Acta Neuropathologica , Vol. 137 2019, Nr. 2, pp. 321 – 341DOI (Open Access)
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Next-generation imaging of the skeletal system and its blood supplyIn: Nature Reviews Rheumatology , Vol. 15 2019, Nr. 9, pp. 533 – 549
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Publisher Correction: Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and responseIn: Nature Communications , Vol. 10 2019, Nr. 1, pp. 2768DOI (Open Access)
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A systematic electron microscopic study on the uptake of barium sulphate nano-, submicro-, microparticles by bone marrow-derived phagocytosing cellsIn: Acta Biomaterialia , Vol. 80 2018, pp. 352 – 363
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Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunityIn: Nature Immunology , Vol. 19 2018, Nr. 12, pp. 1341 – 1351DOI (Open Access)
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Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileusIn: Gut , Vol. 66 2017, Nr. 12, pp. 2110 – 2120DOI (Open Access)
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Three-Dimensional Cross-Sectional Light-Sheet Microscopy Imaging of the Inflamed Mouse GutIn: Gastroenterology , Vol. 153 2017, Nr. 4, pp. 898 – 900
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Visualizing the function and fate of neutrophils in sterile injury and repairIn: Science , Vol. 358 2017, Nr. 6359, pp. 111 – 116
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Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental strokeIn: Acta Neuropathologica , Vol. 129 2015, Nr. 2, pp. 259 – 277
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Traps and hyper inflammation - new ways that neutrophils promote or hinder survivalIn: British Journal of Haematology , Vol. 164 2014, Nr. 2, pp. 189 – 199
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A role for LFA-1 in delaying T-lymphocyte egress from lymph nodesIn: The EMBO Journal , Vol. 32 2013, Nr. 6, pp. 829 – 843
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Cellular immune reactions in the lungIn: Immunological Reviews , Vol. 251 2013, Nr. 1, pp. 189 – 214
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Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammationIn: Blood , Vol. 121 2013, Nr. 24, pp. 4930 – 4937
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Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitorsIn: Blood , Vol. 119 2012, Nr. 22, pp. 5144 – 5154
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Vaccine adjuvants : Tailor-made mast-cell granulesIn: Nature Materials , Vol. 11 2012, Nr. 3, pp. 181 – 182
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G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligandsIn: Blood , Vol. 117 2011, Nr. 16, pp. 4349 – 4357
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Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of HaptensIn: Immunity , Vol. 34 2011, Nr. 6, pp. 973 – 984DOI (Open Access)
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Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilizationIn: Nature Medicine , Vol. 16 2010, Nr. 10, pp. 1141 – 1146
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Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodAIn: PLoS Pathogens , Vol. 6 2010, Nr. 4, pp. e1000873
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Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturationIn: Immunity , Vol. 33 2010, Nr. 1, pp. 84 – 95
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Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bonesIn: Blood , Vol. 114 2009, Nr. 2, pp. 290 – 298DOI (Open Access)
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Guanine Nucleotide-Binding Proteins of the G₁₂ Family Shape Immune Functions by Controlling CD4⁺ T Cell Adhesiveness and MotilityIn: Immunity , Vol. 30 2009, Nr. 5, pp. 708 – 720DOI (Open Access)
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Intravital two-photon microscopy : Focus on speed and time resolved imaging modalitiesIn: Immunological Reviews , Vol. 221 2008, Nr. 1, pp. 7 – 25
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Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicansIn: PLoS Pathogens , Vol. 3 2007, Nr. 2, pp. 0138 – 0151DOI (Open Access)
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Naive B cells generate regulatory T cells in the presence of a mature immunologic synapseIn: Blood , Vol. 110 2007, Nr. 5, pp. 1519 – 1529
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The molecular makeup and function of regulatory and effector synapsesIn: Immunological Reviews , Vol. 218 2007, Nr. 1, pp. 165 – 177
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Systemic administration of a TLR7 ligand leads to transient immune incompetence due to peripheral-blood leukocyte depletionIn: Blood , Vol. 106 2005, Nr. 7, pp. 2424 – 2432
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A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivoIn: Blood , Vol. 104 2004, Nr. 9, pp. 2801 – 2809
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Molecular and functional analysis of Shiga toxin-induced response patterns in human vascular endothelial cellsIn: Blood , Vol. 102 2003, Nr. 4, pp. 1323 – 1332
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Antigen presentation in extracellular matrix : Interactions of T cells with dendritic cells are dynamic, short lived, and sequentialIn: Immunity , Vol. 13 2000, Nr. 3, pp. 323 – 332DOI (Open Access)